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Abstract Objective: Enuresis is associated with attentional and emotional comorbidities in 20 to 30 % of cases. The Short Screening Instrument for Psychological Problems in Enuresis (SSIPPE) is a questionnaire that allows the initial screening of these comorbidities. This study aimed to translate, culturally adapt, and validate the SSIPPE for Brazilian children and adolescents (SSIPPE-Br). Methods: Six steps were performed for translation and cross-cultural adaptation: translation, synthesis of translations, back-translation, preparation of the pre-final version of the translated instrument, test of comprehensibility of the pre-final version of the tool, and elaboration of the instrument cross-culturally adapted for Brazil, named 13-itens version SSIPPE-Br. To validate the SSIPPE-Br, a cross-sectional study was carried out, in which the validated Brazilian version of the Child and Adolescent Behavior Inventory (CABI) was used. Results: Validation was performed on 127 children and adolescents with a mean age of 9.7 ± 2.8 years, 48 % male. The reliability was estimated using Cronbach’s alpha, ranging from 0.86 to 0.89, indicating good internal consistency. The factorial analysis had a good agreement adjustment (KMO 0.755, Bartlett’s test < 0.001) and explained 70.5 % of the data variability. In the reproducibility analysis, the Kappa coefficient ranged from 0.94 to 1, which can be considered almost perfect. A highly significant (p-value < 0.001) and direct correlation existed between the three SSIPPE-Br domains and all evaluated CABI domains. Conclusion: The SSIPPE-Br is a valid and reliable tool for emotional problems screening and ADHD symptoms in children and adolescents with enuresis whose first language is Brazilian Portuguese. Objective 2 3 cases (SSIPPE translate adapt SSIPPEBr. SSIPPEBr Br . (SSIPPE-Br) Methods crosscultural cross cultural adaptation translations backtranslation, backtranslation back back-translation prefinal pre final crossculturally Brazil 13itens itens 13 Br. SSIPPEBr, Br, crosssectional sectional out (CABI used Results 12 97 9 7 9. 28 8 2. years 4 male Cronbachs Cronbach s alpha 086 0 86 0.8 089 89 0.89 consistency KMO 0755 755 0.755 Bartletts Bartlett 0.001 0001 001 705 70 5 70. variability 094 94 0.9 1 perfect pvalue p value Conclusion Portuguese (SSIPPE-Br 08 0. 075 75 0.75 0.00 000 00 09 07 0.7 0.0

https://doi.org/10.1016/j.jped.2023.11.001

Diretriz Brasileira sobre a Saúde Cardiovascular no Climatério e na Menopausa – 2024 202 20 2
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Oliveira, Gláucia Maria Moraes de

; Almeida, Maria Cristina Costa de

; Arcelus, Carolina María Artucio

; Neto Espíndola, Larissa

; Rivera, Maria Alayde Mendonça

; Silva-Filho, Agnaldo Lopes da

; Marques-Santos, Celi

; Fernandes, César Eduardo

; Albuquerque, Carlos Japhet da Matta

; Freire, Claudia Maria Vilas

; Izar, Maria Cristina de Oliveira

; Costa, Maria Elizabeth Navegantes Caetano

; Castro, Marildes Luiza de

; Lemke, Viviana de Mello Guzzo

; Lucena, Alexandre Jorge Gomes de

; Brandão, Andréa Araujo

; Macedo, Ariane Vieira Scarlatelli

; Polanczyk, Carisi Anne

; Lantieri, Carla Janice Baister

; Nahas, Eliana Petri

; Alexandre, Elizabeth Regina Giunco

; Campana, Erika Maria Gonçalves

; Bragança, Érika Olivier Vilela

; Colombo, Fernanda Marciano Consolim

; Barbosa, Imara Correia de Queiroz

; Rivera, Ivan Romero

; Kulak, Jaime

; Moura, Lidia Ana Zytynski

; Pompei, Luciano de Mello

; Baccaro, Luiz Francisco Cintra

; Barbosa, Marcia Melo

; Rodrigues, Marcio Alexandre Hipólito

; Albernaz, Marco Aurelio

; Decoud, Maria Sotera Paniagua de

; Paiva, Maria Sanali Moura de Oliveira

; Sanchez-Zambrano, Martha Beatriz

; Campos, Milena dos Santos Barros

; Acevedo, Monica

; Ramirez, Monica Susana

; Souza, Olga Ferreira de

; Medeiros, Orlando Otávio de

; Carvalho, Regina Coeli Marques de

; Machado, Rogerio Bonassi

; Silva, Sheyla Cristina Tonheiro Ferro da

; Rodrigues, Thais de Carvalho Vieira

; Avila, Walkiria Samuel

; Costa-Paiva, Lucia Helena Simões da

; Wender, Maria Celeste Osorio

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 7 elocation e20240478

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.36660/abc.20240478

Brazilian Guideline on Menopausal Cardiovascular Health – 2024 202 20 2
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Oliveira, Gláucia Maria Moraes de

; Almeida, Maria Cristina Costa de

; Arcelus, Carolina María Artucio

; Espíndola Neto, Larissa

; Rivera, Maria Alayde Mendonça

; Silva-Filho, Agnaldo Lopes da

; Marques-Santos, Celi

; Fernandes, César Eduardo

; Albuquerque, Carlos Japhet da Matta

; Freire, Claudia Maria Vilas

; Izar, Maria Cristina de Oliveira

; Costa, Maria Elizabeth Navegantes Caetano

; Castro, Marildes Luiza de

; Lemke, Viviana de Mello Guzzo

; Lucena, Alexandre Jorge Gomes de

; Brandão, Andréa Araujo

; Macedo, Ariane Vieira Scarlatelli

; Polanczyk, Carisi Anne

; Lantieri, Carla Janice Baister

; Nahas, Eliana Petri

; Alexandre, Elizabeth Regina Giunco

; Campana, Erika Maria Gonçalves

; Bragança, Érika Olivier Vilela

; Colombo, Fernanda Marciano Consolim

; Barbosa, Imara Correia de Queiroz

; Rivera, Ivan Romero

; Kulak, Jaime

; Moura, Lidia Ana Zytynski

; Pompei, Luciano de Mello

; Baccaro, Luiz Francisco Cintra

; Barbosa, Marcia Melo

; Rodrigues, Marcio Alexandre Hipólito

; Albernaz, Marco Aurelio

; Decoud, Maria Sotera Paniagua de

; Paiva, Maria Sanali Moura de Oliveira

; Sanchez-Zambrano, Martha Beatriz

; Campos, Milena dos Santos Barros

; Acevedo, Monica

; Ramirez, Monica Susana

; Souza, Olga Ferreira de

; Medeiros, Orlando Otávio de

; Carvalho, Regina Coeli Marques de

; Machado, Rogerio Bonassi

; Silva, Sheyla Cristina Tonheiro Ferro da

; Rodrigues, Thais de Carvalho Vieira

; Avila, Walkiria Samuel

; Costa-Paiva, Lucia Helena Simões da

; Wender, Maria Celeste Osorio

Revista Brasileira de Ginecologia e Obstetrícia

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2024, Volume 46 elocation e-rbgo100

Abstract: En | Text: En | PDF: En

https://doi.org/10.61622/rbgo/2024rbgo100

Safety of CoronaVac and ChAdOx1 vaccines against SARS-CoV-2 in patients with rheumatoid arthritis: data from the Brazilian multicentric study safer ChAdOx SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- arthritis SARS-CoV
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Cruz, Vitor Alves

; Guimarães, Camila

; Rêgo, Jozelia

; Machado, Ketty Lysie Libardi Lira

; Miyamoto, Samira Tatiyama

; Burian, Ana Paula Neves

; Dias, Laiza Hombre

; Pretti, Flavia Zon

; Batista, Danielle Cristina Filgueira Alves

; Mill, José Geraldo

; Oliveira, Yasmin Gurtler Pinheiro de

; Gadelha, Carolina Strauss Estevez

; Gouveia, Maria da Penha Gomes

; Moulin, Anna Carolina Simões

; Souza, Bárbara Oliveira

; Aguiar, Laura Gonçalves Rodrigues

; Vieira, Gabriel Smith Sobral

; Grillo, Luiza Lorenzoni

; Lima, Marina Deorce de

; Pasti, Laís Pizzol

; Surlo, Heitor Filipe

; Faé, Filipe

; Moulaz, Isac Ribeiro

; Macabú, Mariana de Oliveira

; Ribeiro, Priscila Dias Cardoso

; Magalhães, Vanessa de Oliveira

; Aguiar, Mariana Freitas de

; Biegelmeyer, Erika

; Peixoto;, Flávia Maria Matos Melo Campos

; Kayser, Cristiane

; Souza, Alexandre Wagner Silva de

; Castro, Charlles Heldan de Moura

; Ribeiro, Sandra Lúcia Euzébio

; Telles, Camila Maria Paiva França

; Bühring, Juliana

; Lima, Raquel Lima de

; Santos, Sérgio Henrique Oliveira Dos

; Dias, Samuel Elias Basualto

; Melo, Natália Seixas de

; Sanches, Rosely Holanda da Silva

; Boechat, Antonio Luiz

; Sartori, Natália Sarzi

; Hax, Vanessa

; Dória, Lucas Denardi

; Rezende, Rodrigo Poubel Vieira de

; Baptista, Katia Lino

; Fortes, Natália Rodrigues Querido

; Melo, Ana Karla Guedes de

; Melo, Tâmara Santos

; Vieira, Rejane Maria Rodrigues de Abreu

; Vieira, Adah Sophia Rodrigues

; Kakehasi, Adriana Maria

; Tavares, Anna Carolina Faria Moreira Gomes

; Landa, Aline Teixeira de

; Costa, Pollyana Vitoria Thomaz da

; Azevedo, Valderilio Feijó

; Martins-Filho, Olindo Assis

; Peruhype-Magalhães, Vanessa

; Pinheiro, Marcelo de Medeiros

; Monticielo, Odirlei André

; Reis-neto, Edgard Torres Dos

; Ferreira, Gilda Aparecida

; Souza, Viviane Angelina de

; Teixeira-Carvalho, Andréa

; Xavier, Ricardo Machado

; Sato, Emilia Inoue

; Valim, Valeria

; Pileggi, Gecilmara Salviato

; Silva, Nilzio Antonio da

Advances in Rheumatology

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2024, Volume 64 elocation 58

Abstract: En | Text: En | PDF: En

Abstract Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with associated comorbidities. However, few studies have assessed the safety of the COVID-19 vaccine in patients with RA. Objective To evaluate the safety of vaccines against SARS-CoV-2 in patients with RA. Methods This data are from the study “Safety and Efficacy on COVID-19 Vaccine in Rheumatic Diseases,” a Brazilian multicentric prospective phase IV study to evaluate COVID-19 vaccine in IMRDs in Brazil. Adverse events (AEs) in patients with RA of all centers were assessed after two doses of ChAdOx1 (Oxford/AstraZeneca) or CoronaVac (Sinovac/Butantan). Stratification of postvaccination AEs was performed using a diary, filled out daily and returned at the end of 28 days for each dose. Results A total of 188 patients with RA were include, 90% female. CoronaVac was used in 109 patients and ChAdOx1 in 79. Only mild AEs were observed, mainly after the first dose. The most common AEs after the first dose were pain at the injection (46,7%), headache (39,4%), arthralgia (39,4%), myalgia (30,5%) and fatigue (26,6%), and ChAdOx1 had a higher frequency of pain at the injection (66% vs 32 %, p < 0.001) arthralgia (62% vs 22%, p < 0.001) and myalgia (45% vs 20%, p < 0.001) compared to CoronaVac. The more common AEs after the second dose were pain at the injection (37%), arthralgia (31%), myalgia (23%), headache (21%) and fatigue (18%). Arthralgia (41,4% vs 25%, p = 0.02) and pain at injection (51,4% vs 27%, p = 0.001) were more common with ChAdOx1. No serious AEs were related. With Regard to RA activity level, no significant difference was observed between the three time periods for both COVID-19 vaccines. Conclusion In the comparison between the two immunizers in patients with RA, local reactions and musculoskeletal symptoms were more frequent with ChAdOx1 than with CoronaVac, especially after the first dose. In summary, the AE occurred mainly after the first dose, and were mild, like previous data from others immunizing agents in patients with rheumatoid arthritis. Vaccination did not worsen the degree of disease activity. immunemediated immune mediated (IMRDs COVID19 COVID 19 COVID-1 risks (RA outcomes comorbidities However SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- Safety Diseases, Diseases Brazil (AEs ChAdOx Oxford/AstraZeneca OxfordAstraZeneca Oxford AstraZeneca (Oxford/AstraZeneca Sinovac/Butantan. SinovacButantan Sinovac/Butantan . Sinovac Butantan (Sinovac/Butantan) diary 18 include 90 female 10 79 46,7%, 467 46,7% , 46 7 (46,7%) 39,4%, 394 39,4% 39 4 (39,4%) 30,5% 305 30 5 (30,5% 26,6%, 266 26,6% 26 6 (26,6%) 66% 66 (66 3 % 0.001 0001 0 001 62% 62 (62 22 22% 45% 45 (45 20 20% 37%, 37 37% (37%) 31%, 31 31% (31%) 23%, 23 23% (23%) 21% 21 (21% 18%. 18% (18%) 41,4% 414 41 (41,4 25 25% 0.02 002 02 51,4% 514 51 (51,4 27 27% related level summary COVID1 1 COVID- SARS-CoV (Sinovac/Butantan 9 46,7 (46,7% 39,4 (39,4% 30,5 (30,5 26,6 (26,6% (6 0.00 000 00 (4 (37% (31% (23% (21 (18% 41,4 (41, 0.0 51,4 (51, 46, (46,7 39, (39,4 30, (30, 26, (26,6 ( (37 (31 (23 (2 (18 41, (41 0. 51, (51 (46, (39, (30 (26, (3 (1 (5 (46 (39 (26

https://doi.org/10.1186/s42358-024-00397-5

Validation of the Vancouver Symptom Score Questionnaire for bladder and bowel dysfunction for Brazilian children and adolescents
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Pinto, Fernanda Nunes Coelho Siqueira

; de Bessa Junior, José

; Bastos Netto, José Murillo

; Dias, Gláucia Cristina Medeiros

; Vasconcelos, Mônica Maria de Almeida

; Lima, Eleonora Moreira

; Almeida, Tailly de Souza

; Silva, Ana Cristina Simões e

; Mrad, Flávia Cristina de Carvalho

International braz j urol

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feb 2023, Volume 49 N. 1 Pages 110 - 122

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: This study aimed to translate, and perform a cross-cultural adaptation, and validation of the Vancouver Symptom Score (VSS) for bladder and bowel dysfunction (BBD) for Brazilian children and adolescents Materials and Methods: Six steps were performed for the translation and cross-cultural adaptation: (1) translation, (2) synthesis of translations, (3) back-translation, (4) pre-final version of the translated instrument, (5) pilot test and degree of comprehensibility and (6) elaboration of the Brazilian version of the VSS. For validation, the Brazilian Dysfunctional Voiding Score (DVSS) questionnaire was used. Results: Validation was performed on a sample of 107 children and adolescents with a mean age of 9.2 ± 2.84 years, presenting BBD and 107 without BBD (control group-CG). There was a positive correlation (r = 0.91, 95% CI 0.88 to 0.93, p < 0.0001) between total VSS score and total DVSS score. VSS was higher in patients with BBD (p < 0.0001). The internal consistency estimated by Cronbach's alpha was 0.87 for patients with BBD. The VSS showed excellent diagnostic accuracy in detecting cases, with an area under the ROC curve of 98% (95% CI 0.96 to 0.99, p < 0.001). A cut-off value of >11 points produced a sensitivity of 100% (95% CI 96.4% to 100%) and a specificity of 91.8% (95% CI 85.1% to 95.6%). Conclusion: The translated, cross-culturally adapted, and validated VSS for the Brazilian population is a reliable and valid tool to identify symptoms of BBD in children and adolescents aged five to 16 years, whose first language is Brazilian Portuguese. Objective translate crosscultural cross cultural adaptation (VSS (BBD Methods 1 (1 2 (2 translations 3 (3 backtranslation, backtranslation back back-translation 4 (4 prefinal pre final instrument 5 (5 6 (6 (DVSS used Results 10 92 9 9. 284 84 2.8 years control groupCG. groupCG group CG . group-CG) r 091 0 91 0.91 95 088 88 0.8 093 93 0.93 0.0001 00001 0001 0.0001. Cronbachs Cronbach s 087 87 cases 98 (95 096 96 0.9 099 99 0.99 0.001. 0.001 001 0.001) cutoff cut off 11 >1 100 964 96.4 918 8 91.8 851 85 85.1 95.6%. 956 95.6% 95.6%) Conclusion crossculturally culturally adapted Portuguese ( 28 2. group-CG 09 08 0. 0.000 0000 000 (9 0.00 00 > 96. 91. 85. 95.6 0.0 95.

https://doi.org/10.1590/s1677-5538.ibju.2022.0495

Favorable Safety Experience of Local Dental Anesthesia in ICD Recipients with Cardiac Channelopathies
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Oliveira, Ana Carolina Guimarães

; Neves, Itamara Lucia Itagiba

; Sacilotto, Luciana

; Olivetti, Natália Quintella Sangiorgi

; Bueno, Savia Christina Pereira

; Pessente, Gabrielle D’Arezzo

; Santos-Paul, Marcela Alves dos

; Montano, Tânia Cristina Pedroso

; Carvalho, Cíntia Maria Alencar de

; Grupi, Cesar José

; Barbosa, Sílvio Alves

; Pastore, Carlos Alberto

; Samesima, Nelson

; Wu, Tan Chen

; Hachul, Denise Tessariol

; Scanavacca, Maurício Ibrahim

; Neves, Ricardo Simões

; Darrieux, Francisco Carlos da Costa

International Journal of Cardiovascular Sciences

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2023, Volume 36 elocation e20200312

Abstract: En | Text: En | PDF: En

Abstract Background Dental anesthetic management in implantable cardioverter defibrillator (ICD) recipients with cardiac channelopathies (CCh) can be challenging due to the potential risk of life-threatening arrhythmias and appropriate ICD therapies during procedural time. Objectives The present study assessed the hypothesis that the use of local dental anesthesia with 2% lidocaine with 1:100,000 epinephrine or without a vasoconstrictor can be safe in selected ICD and CCh patients, not resulting in life-threatening events (LTE). Methods Restorative dental treatment under local dental anesthesia was made in two sessions, with a wash-out period of 7 days (cross-over trial), conducting with a 28h - Holter monitoring, and 12-lead electrocardiography, digital sphygmomanometry, and anxiety scale assessments in 3 time periods. Statistical analysis carried out the paired Student’s t test and the Wilcoxon signed-rank test. In all cases, a significance level of 5% was adopted. All patients were in stable condition with no recent events before dental care. Results Twenty-four consecutive procedures were performed in 12 patients (9 women, 3 men) with CCh and ICD: 7 (58.3%) had long QT syndrome (LQTS), 4 (33.3%) Brugada syndrome (BrS), and 1 (8.3%) Catecholaminergic polymorphic ventricular tachycardia (CPVT). Holter analysis showed no increased heart rate (HR) or sustained arrhythmias. Blood pressure (BP), electrocardiographic changes and anxiety measurement showed no statistically significant differences. No LTE occurred during dental treatment, regardless of the type of anesthesia. Conclusion Lidocaine administration, with or without epinephrine, can be safely used in selected CCh-ICD patients without LTE. These preliminary findings need to be confirmed in a larger population with ICD and CCh. (ICD (CCh lifethreatening life threatening 2 1100,000 1100000 100,000 100 000 1:100,00 . (LTE) sessions washout wash crossover cross over trial, trial , trial) h monitoring 12lead lead electrocardiography sphygmomanometry periods Students Student s signedrank signed rank cases 5 adopted care Twentyfour Twenty four 9 ( women men 58.3% 583 58 (58.3% LQTS, LQTS (LQTS) 33.3% 333 33 (33.3% BrS, BrS (BrS) 8.3% 83 8 (8.3% CPVT. CPVT (CPVT) HR (HR BP, BP (BP) differences administration CChICD 1100 1100,00 110000 100000 100,00 10 00 1:100,0 (LTE 58.3 (58.3 (LQTS 33.3 (33.3 (BrS 8.3 (8.3 (CPVT (BP 110 1100,0 11000 10000 100,0 0 1:100, 58. (58. 33. (33. 8. (8. 11 1100, 1000 100, 1:100 (58 (33 (8 1:10 (5 (3 1:1 1:

https://doi.org/10.36660/ijcs.20200312

Brazilian Portuguese version and content validity of the Strengthening and Stretching for Rheumatoid Arthritis of the Hand (SARAH) SARAH (SARAH
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Castro, Rayane Quintão

; Barros, Lívia Vilela

; Carvalho, Pedro Henrique Berbert de

; Fonseca, Diogo Simões

; Miyamoto, Samira Tatiyama

; Coelho, Cristina Martins

; Machado, Germano Luís Rocha

; Forechi, Ludimila

Advances in Rheumatology

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2023, Volume 63 elocation 2

Abstract: En | Text: En | PDF: En

Abstract Introduction The Strengthening and Stretching for Rheumatoid Arthritis of the Hand (SARAH) program is a personalized, progressive 12-week exercise program for people with hand problems due to rheumatoid arthritis (RA). Patients are provided with two guidance documents, the ‘Patient Exercise Booklet’ and the ‘Personal Exercise Guide’, to continue the exercises independently at home. Objective This study aimed to translate and culturally adapt the SARAH protocol into Brazilian Portuguese and validate its content. Methods The guidance documents ‘Patient Exercise Booklet’ and ‘Personal Exercise Guide’ of the SARAH program were translated and culturally adapted to Brazilian Portuguese. The content validity was obtained by calculating the content validity index (CVI). Results The Brazilian version of the SARAH protocol reached semantic, idiomatic, conceptual, and cultural equivalences. The CVI was greater than 0.8, corresponding to a satisfactory index. The verbal comprehension was 4.9, showing good verbal comprehension ofthe target population. Conclusion The Brazilian Portuguese version of the SARAH protocol is available to Brazilian people with compromised hands due to RA with satisfactory content validity. (SARAH personalized 12week week 12 RA. . (RA) Patient Booklet Personal Guide, Guide , home CVI. (CVI) semantic idiomatic conceptual equivalences 08 0 8 0.8 49 4 9 4.9 population 1 (RA (CVI 0. 4.

https://doi.org/10.1186/s42358-022-00284-x

Relationship between primary monosymptomatic enuresis and process toilet training: a case-control
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Carvalho, Tânia Antunes

; Vasconcelos, Mônica Maria de Almeida

; Bessa Junior, José de

; Bastos Netto, José Murillo

; Dutra, Melissa Faria

; Guimarães, Isabela Cristina de Oliveira

; Lima, Eleonora Moreira

; Silva, Ana Cristina Simões e

; Mrad, Flávia Cristina de Carvalho

International braz j urol

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dec 2022, Volume 48 N. 6 Pages 944 - 951

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: Primary monosymptomatic nocturnal enuresis (PMNE) is a prevalent condition in childhood, and the pathophysiology is multifactorial. This study investigated the relationship between the toilet training process (TT) and PMNE in children and adolescents. Patients and Methods: A case-control study was carried out from 2015 to 2020. The presence of PMNE was identified according to International Children's Continence Society criteria. A semi-structured questionnaire was applied to assess TT. Results: The study included 103 children and adolescents with PMNE and 269 participants with normal psychomotor development without PMNE (control group [CG]). Readiness signals were more remembered and less frequent in participants with PMNE (p=0.001) when compared to control group. No differences were found between the groups regarding the onset age of the daytime TT (p= 0.10), the nocturnal TT (p=0.08), the acquisition of daytime continence (p=0.06), and the type of equipment used for the TT (p=0.99). The use of Child-Oriented approach in group of children with enuresis was lower than in controls [87.4% (90/103) versus 94% (250/266)], respectively (OR= 0.44, 95% CI 0.21-0.94, p = 0.039). Conclusions: The age of onset of TT, acquisition of daytime continence, and the type of equipment were not associated with higher occurrence of PMNE. On the other hand, the Child-Oriented approach was a protective factor for the occurrence of PMNE.

https://doi.org/10.1590/s1677-5538.ibju.2022.0381

Risk factors for acute kidney injury after liver transplantation in intensive care unit: a retrospective cohort study
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Neves, Ana Paula Camargos de Figueirêdo

; Gomes, Angélica Gomides dos Reis

; Vassallo, Paula Frizera

; Silva, Ana Cristina Simões e

; Penna, Francisco Guilherme Cancela e

; Bastos, Fabrício de Lima

; Muniz, Mateus Rocha

; Rocha, Guilherme Carvalho

; Santos Júnior, Augusto Cesar Soares dos

; Ravetti, Cecilia Gómez

; Nobre, Vandack

Sao Paulo Medical Journal

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aug 2022, Volume 140 N. 4 Pages 559 - 565

Abstract: En | Text: En | PDF: En

ABSTRACT BACKGROUND: Acute kidney injury (AKI) is a frequent complication during the postoperative period following liver transplantation. Occurrence of AKI in intensive care unit (ICU) patients is associated with increased mortality and higher costs. OBJECTIVE: To evaluate occurrences of moderate or severe AKI among patients admitted to the ICU after liver transplantation and investigate characteristics associated with this complication. DESIGN AND SETTING: Single-center retrospective cohort study in a public hospital, Belo Horizonte, Brazil. METHODS: Forty-nine patients admitted to the ICU between January 2015 and April 2017 were included. AKI was defined from a modified Kidney Disease Improving Global Outcomes (KDIGO) score (i.e. based exclusively on serum creatinine levels). RESULTS: Eighteen patients (36.7%) developed AKI KDIGO 2 or 3; mostly KDIGO 3 (16 out of the 18 patients). Lactate level within the first six hours after ICU admission (odds ratio, OR: 1.3; 95% confidence interval, CI: 1.021-1.717; P = 0.034) and blood transfusion requirement within the first week following transplantation (OR: 8.4; 95% CI: 1.687-41.824; P = 0.009) were independently associated with development of AKI. Patients with AKI KDIGO 2 or 3 underwent more renal replacement therapy (72.2% versus 3.2%; P < 0.01), had longer hospital stay (20 days versus 15 days; P = 0.001), higher in-hospital mortality (44.4% versus 6.5%; P < 0.01) and higher mortality rate after one year (44.4% versus 9.7%; P = 0.01). CONCLUSION: Need for blood transfusion during ICU stay and hyperlactatemia within the first six postoperative hours after liver transplantation are independently associated with moderate or severe AKI. Developing AKI is apparently associated with poor outcomes.

https://doi.org/10.1590/1516-3180.2021.0641.r2.12112021

10.

ABSENTEEISM IN NURSING IN THE FACE OF COVID-19: A COMPARATIVE STUDY IN A HOSPITAL FROM SOUTHERN BRAZIL
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Alves, Ana Bárbara Simões Luz

; Matos, Fabiana Gonçalves de Oliveira Azevedo

; Carvalho, Ariana Rodrigues da Silva

; Alves, Débora Cristina Ignácio

; Tonini, Nelsi Salete

; Santos, Reginaldo Passoni dos

; Nishiyama, Juliana Aparecida Peixoto

; Oliveira, João Lucas Campos de

Texto & Contexto - Enfermagem

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2022, Volume 31 elocation e20210254

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo comparar o absenteísmo da enfermagem hospitalar, antes e durante a pandemia da COVID-19. Método estudo transversal. Compilaram-se os registros de afastamento do trabalho da enfermagem de um hospital universitário sul-brasileiro nos meses de março, abril e maio de 2019 (n=622) e no mesmo período em 2020 (n=475). Os dados foram analisados por estatística descritiva e analítica. Resultados nos dois períodos, foram equânimes as frequências de afastamentos de mulheres (98,4%; 98,3%), com idade entre 40 e 49 anos (47,9%; 44,8%) e atuantes em enfermarias para adultos (30,7%; 29,2%). O absenteísmo-doença foi a causa prevalente (48,4%; 48%). O número absoluto de casos de afastamento foi maior no período pré-pandemia, contudo, o tempo em dias e horas perdidas, bem como a taxa de absenteísmo (13,9; 18,6%), foram significativamente mais elevados (p-valor<0,001) no período de pandemia vigente. Conclusão a pandemia de COVID-19 impactou na elevação do absenteísmo da enfermagem hospitalar.

ABSTRACT Objective to compare absenteeism in Hospital Nursing before and during the COVID-19 pandemic. Method cross-sectional study. It involved compilation of the records of absence from Nursing work at a university hospital in southern Brazil in March, April and May 2019 (n=622) and during the same period in 2020 (n=475). The data were analyzed by means of descriptive and analytical statistics. Results both periods presented the same absence frequencies in women (98.4%; 98.3%), aged between 40 and 49 years old (47.9%; 44.8%) and working in wards for adults (30.7%; 29.2%). Absenteeism-Disease was the most prevalent cause (48.4%; 48%). The absolute number of absence cases was higher in the pre-pandemic period; however, the time in days and hours lost, as well as the absenteeism rate (13.9; 18.6%), was significantly higher (p-value<0.001) in the current pandemic period. Conclusion the COVID-19 pandemic exerted an impact on the increase in Hospital Nursing absenteeism.

RESUMEN Objetivo comparar el ausentismo en el área de Enfermería hospitalaria, antes y durante la pandemia de COVID-19. Método estudio transversal. Se compilaron los registros de ausencias laborales en el área de Enfermería de un hospital universitario del sur de Brasil durante los meses de marzo, abril y mayo de 2019 (n=622) y en el mismo período del año 2020 (n=475). Los datos se analizaron por medio de estadística descriptiva y analítica. Resultados en ambos períodos, las frecuencias en términos de ausencias laborales fueron equivalentes en mujeres (98,4%; 98,3%), de entre 40 y 49 años (47,9%; 44,8%) y que desempeñaban sus funciones en salas para adultos (30,7%; 29,2%). Ausentismo/Enfermedad fue la causa prevalente (48,4%; 48%). La cantidad absoluta de casos de ausencias laborales fue mayor durante el período previo a la pandemia; sin embargo, el tiempo en días y horas perdidas, así como el índice de ausentismo (13,9; 18,6%), fueron significativamente más elevados (valor-p<0,001) durante el período de pandemia actual. Conclusión la pandemia de COVID-19 repercutió en el aumento del ausentismo en el área de Enfermería hospitalaria.

https://doi.org/10.1590/1980-265x-tce-2021-0254

11.

Quinolinotriazole antiplasmodials via click chemistry: synthesis and in vitro studies of 7-Chloroquinoline-based compounds
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Pereira, Guilherme Rocha

; Ferreira, Andreza Cristina Gomes

; Neves, Pedro Henrique de Almeida Simões

; Gomes, Erick Bruman Souza

; Nascimento, Maria Fernanda Alves do

; Sousa, Jordano Augusto Carvalho

; Santos, Juliana de Oliveira

; Brandão, Geraldo Célio

; Oliveira, Alaíde Braga de

Brazilian Journal of Pharmaceutical Sciences

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2021, Volume 57 elocation e181086

Abstract: En | Text: En | PDF: En

Malaria is nowadays one of the most serious health concerns in a global scale and, although there is an evident increase in research studies in this area, pointed by the vast number of hits and leads, it still appears as a recurrent topic every year due to the drug resistance shown by the parasite exposing the urgent need to develop new antimalarial medications. In this work, 38 molecules were synthesized via copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) or “click” chemistry, following different routes to produce 2 different organic azides, obtained from a 4,7 dicholoquinoline, reacted with 19 different commercially available terminal alkynes. All those new compounds were evaluated for their in vitro activity against the chloroquine resistant malaria parasite Plasmodium falciparum (W2). The cytotoxicity evaluation was accomplished using Hep G2 cells and SI index was calculated for every molecule. Some of the quinoline derivatives have shown high antimalarial activity, with IC50 values in the range of 1.72-8.66 µM, low cytotoxicity, with CC50>1000 µM and selectivity index (SI) in the range of 20-100, with some compounds showing SI>800. Therefore, the quinolinotriazole hybrids could be considered a very important step on the development of new antimalarial drugs.

https://doi.org/10.1590/s2175-979020200004181086 1 downloads

12.

Avaliação da exposição a BTEX em postos de revenda de combustíveis no Rio de Janeiro, Brasil, e os riscos à saúde do trabalhador
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Figueiredo, Victor Oliva

; Carvalho, Leandro Vargas Barreto de

; Borges, Renato Marçullo

; Costa-Amaral, Isabele Campos

; Santos, Marcus Vinicius Corrêa dos

; Rosa, Ana Cristina Simões

; Menezes, Marco Antônio Carneiro de

; Mattos, Rita de Cássia Oliveira da Costa

; Sarcinelli, Paula Novaes

; Alves, Sergio Rabello

; Larentis, Ariane Leites

; Gonçalves, Eline Simões

Cadernos de Saúde Pública

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2021, Volume 37 N. 11 elocation e00351520

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

A gasolina é uma mistura complexa de substâncias, dentre elas estão hidrocarbonetos como o benzeno, tolueno, etilbenzeno e xilenos (BTEX), sendo esses compostos emitidos para a atmosfera, com destaque ao benzeno, por ser comprovadamente carcinogênico. Objetivamos avaliar as concentrações de BTEX no ar de postos de revenda de combustíveis no Município do Rio de Janeiro, Brasil, e calcular o risco de câncer associado a estas exposições. Foram realizados dois tipos de amostragem (fixa e móvel) adaptadas da metodologia nº 1.501 do Instituto Nacional de Segurança e Saúde Ocupacional (Estados Unidos), em seis postos de revenda de combustíveis na Zona Oeste da cidade. A amostragem fixa foi feita próxima às bombas de combustível, enquanto a móvel foi realizada através da coleta do ar na zona respiratória dos trabalhadores (frentistas), conforme estes se deslocavam pelo posto. As amostras foram analisadas por cromatografia gasosa com detecção por ionização em chama. Com os resultados das amostragens foram feitos os cálculos de risco à saúde, usando os indicadores Quociente de perigo (HQ) e Risco de câncer (CR), para avaliar os possíveis efeitos não-carcinogênicos e carcinogênicos, respectivamente, nos trabalhadores dos postos de revenda de combustíveis. As concentrações ambientais para a maioria dos compostos BTEX foram abaixo dos limites preconizados, menos para o benzeno, um composto carcinogênico, que apresentou concentrações muito acima dos limites, levando a altos valores de risco de câncer. Os resultados demonstraram que há riscos à saúde dos trabalhadores de postos de revenda de combustíveis, principalmente o risco de desenvolver câncer, devido à exposição excessiva ao benzeno.

La gasolina es una mezcla compleja de sustancias, entre ellas existen hidrocarburos como el benceno, tolueno, etilbenceno y xilenos (BTEX), emitiéndose estos compuestos a la atmósfera, donde se destaca el benceno, al tratarse de un carcinogénico comprobado. Los objetivos fueron evaluar las concentraciones de BTEX en el aire de puestos de reventa de combustibles, en el municipio de Río de Janeiro, Brasil, así como calcular el riesgo de cáncer asociado a estas exposiciones. Se realizaron dos tipos de muestra (fija y movible), adaptadas de la metodología nº 1.501 del Instituto Nacional de Seguridad y Salud Laboral (EE.UU.), en seis puestos de reventa de combustibles de la zona oeste de la ciudad. La muestra fija se realizó cerca de las bombas de combustible, mientras que la móvil se hizo mediante tomas de aire en la zona respiratoria de los trabajadores (de la gasolinera), a medida que estos se desplazaban por el lugar de trabajo. Las muestras se analizaron por cromatografía gaseosa con detección por ionización en llama. Junto a los resultados de las muestras, se realizaron cálculos de riesgo para la salud, usando los indicadores Cociente de peligro (HQ) y Riesgo de cáncer (CR), con el fin de evaluar los posibles efectos no-carcinogénicos y carcinogénicos, respectivamente, en los trabajadores de los puestos de reventa de combustibles. Las concentraciones ambientales para la mayoría de los compuestos BTEX estuvieron por debajo de los limites preconizados, menos en el caso del benceno, un compuesto carcinogénico, que presentó concentraciones muy por encima de los límites, llevando a altos valores de riesgo de cáncer. Los resultados demostraron que existen riesgos para la salud de los trabajadores de puestos de reventa de combustibles, principalmente, riesgo de desarrollar cáncer, debido a la exposición excesiva al benceno.

Gasoline is a complex mixture of substances, including aromatic hydrocarbons such as benzene, toluene, ethylbenzene, and xylenes (BTEX). These compounds are emitted into the air, with the special relevance of benzene since it is provenly carcinogenic. The study aimed to assess BTEX concentrations in filling stations in the city of Rio de Janeiro, Brazil, and to calculate the cancer risk associated with such exposures. Two types of sampling were performed (stationary and mobile), adapted from methodology n. 1,501 (U.S. National Institute for Occupational Safety and Health) for aromatic hydrocarbons, in six filling stations in the West Zone of Rio de Janeiro. Stationary sampling was done near the fuel pumps, while mobile sampling was done in the breathing zone of the workers (station attendants) as they moved around the station. The samples were analyzed with gas chromatography flame ionization detector. The sampling results were used to calculate the health risk, using the indicators Hazard quotient (HQ) and Cancer risk (CR) to assess the possible non-carcinogenic and carcinogenic effects, respectively, in filling station workers. Environmental concentrations for the most of the BTEX compounds were below the recommended limits, except for benzene, a carcinogenic compound, which displayed concentrations far above the limits, leading to high cancer risk values. The results showed that there are health risks for filling station attendants, especially the risk of developing cancer from excessive exposure to benzene.

https://doi.org/10.1590/0102-311x00351520

13.

Avaliação da exposição a BTEX em postos de revenda de combustíveis no Rio de Janeiro, Brasil, e os riscos à saúde do trabalhador Janeiro Brasil
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Figueiredo, Victor Oliva

; Carvalho, Leandro Vargas Barreto de

; Borges, Renato Marçullo

; Costa-Amaral, Isabele Campos

; Santos, Marcus Vinicius Corrêa dos

; Rosa, Ana Cristina Simões

; Menezes, Marco Antônio Carneiro de

; Mattos, Rita de Cássia Oliveira da Costa

; Sarcinelli, Paula Novaes

; Alves, Sergio Rabello

; Larentis, Ariane Leites

; Gonçalves, Eline Simões

Cadernos de Saúde Pública

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2021, Volume 37 N. 11 elocation e00351520

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

https://doi.org/10.1590/0102-311x00351520 2 downloads

14.

Situation of study (SoS) on health education implemented in a co-creation (CoC) process
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Carvalho, Graça Simões de

; Boff, Eva Teresinha de Oliveira

; Araújo, Maria Cristina Pansera de

Revista Brasileira de Educação

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2021, Volume 26 elocation e260012

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO A situação de estudo (SoS) tem revelado ser uma estratégia eficiente para promoção de aprendizagens significativas. Este estudo teve como objetivo demonstrar como uma SdE sobre educação em saúde (“Conhecendo o câncer: um caminho para a vida”) pode ser implementada no âmbito do processo de cocriação (CoC). O estudo foi realizado numa escola de ensino médio, com a participação de cinco grupos: alunos (14-15 anos), professores, futuros professores, formadores universitários de professores e profissionais de saúde. As dez atividades foram realizadas na escola e no exterior em cinco meses, desenvolvendo um processo de ciclo autorreflexivo: “refletir e planejar”, “atuar e observar” e “analisar e refletir”. As transcrições dos debates e dos textos dos alunos e professores foram submetidas a análise de conteúdo. Este estudo demonstrou que a Situação de Estudo implementada em um processo de cocriação foi muito eficiente para os alunos desenvolverem um aprendizado significativo.

ABSTRACT Situation of study (SoS) has been reported as an excellent strategy to promote students’ significant learning. This work intended to demonstrate how a SoS on health education (“Knowing cancer: a way to life”) can be implemented within the co-creation (CoC) framework. The study was carried out in a middle school, with the participation of five groups: students (14-15 years old), teachers, future teachers, university teacher trainers and health professionals. The 10 activities were carried out in school and outdoors for five months, undergoing a process of self-reflexive cycle: “reflecting and planning”, “acting and observing”, and “analyzing and reflecting”. Transcripts of debates and of students’ and teachers’ texts were subject to content analysis. This study on a topic of health education demonstrated that the Situation of Study implemented in a co-creation process was very efficient for students to develop significant learning.

RESUMEN La situación de estudio (SdE) es una excelente estrategia para la promoción de aprendizajes significativos. El objetivo de este trabajo es demostrar cómo una SdE sobre educación en salud (“Conociendo el cáncer: un camino para la vida”) puede ser implementada en el ámbito del proceso de co-creación (CoC). El estudio fue realizado en una escuela de educación secundaria, con la participación de 5 grupos: estudiantes (14-15 años), profesores, futuros profesores, formadores universitarios de profesores y profesionales de salud. Las diez actividades fueron realizadas en la escuela y en el exterior durante cinco meses, desarrollando un proceso de ciclo autorreflexivo “reflexionar y planear”, “actuar y observar” y “analizar y reflexionar”. Las transcripciones de los debates y los textos de estudiantes y profesores fueron sometidos a análisis de contenido. Este estudio demostró que la situación de estudio fue muy eficiente para que los estudiantes desarrollen aprendizajes significativos.

https://doi.org/10.1590/s1413-24782021260012 388 downloads

15.

CONCEPÇÕES E REPRESENTAÇÕES SOCIAIS DE PROFESSORES SOBRE A SUA FORMAÇÃO INICIAL: CONSTRUÇÃO E VALIDAÇÃO DE UM QUESTIONÁRIO
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MAGALHÃES JÚNIOR, CARLOS ALBERTO DE OLIVEIRA

; CORAZZA, MARIA JÚLIA

; KIOURANIS, NEIDE MARIA MICHELLAN

; PANSERA-DE-ARAÚJO, MARIA CRISTINA

; OLIVEIRA, ANDRÉ LUIS

; MARICATO, FÚLVIA ELOÁ

; SCHNEIDER, EDUARDA MARIA

; ORTIZ, ADRIANO JOSÉ

; CARMO, TÂNIA DO

; CARVALHO, JOICI LEITE DE

; ARAÚJO, JOÃO LUIS DEQUI

; RANGEL, MARY

; GIMENES, EDER RODRIGO

; CARVALHO, GRAÇA SIMÕES

Ensaio Pesquisa em Educação em Ciências (Belo Horizonte)

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2020, Volume 22 elocation e12364

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO: Este estudo versa sobre a validação de um questionário aplicado aos licenciandos do primeiro e último ano das licenciaturas em Biologia, Ciências, Física, Química e Pedagogia, sendo selecionadas duas diferentes instituições para cada curso. O instrumento de pesquisa passou pela validação semântica, realizada por seis pesquisadores doutores das áreas de Ensino (Biologia, Física e Química) e a aplicação de um teste piloto com licenciandos do curso de Biologia. Após a análise semântica e o teste piloto, três assertivas foram eliminadas, ficando o questionário final constituído por 81 assertivas. Para avaliar a confiabilidade do instrumento (validação estatística) foi realizado o teste de Alpha de Cronbach, análise fatorial, Kaiser-Meyer-Olklin (KMO) e o de Esfericidade de Bartlett. Após a aplicação dos testes foram eliminadas 30 assertivas, tornando possível a Análise dos Componentes Principais (ACP). O número amostral foi considerado satisfatório para a sistematização e análise dos dados, quando analisado o valor do KMO.

ABSTRACT: The present study concerns the validation of a questionnaire applied to first and last year undergraduate students in Biology, Sciences, Physics, Chemistry and Pedagogy, being selected two different institutions for each course. The research instrument went through the semantic validation, carried out by six PhD researchers in the areas of Teaching (Biology, Physics and Chemistry) and also through a pilot test with Biology students. After the semantic analysis and the pilot test, three questions were deleted so that the final questionnaire became composed of 81 questions. To evaluate the reliability of the instrument (statistical validation) the Cronbach Alpha test, factorial analysis, Kaiser-Meyer-Olklin (KMO) and Bartlett’s Sphericity were carried out. After the application of these tests, 30 assertions were eliminated, making the Principal Component Analysis (PCA) possible. The sample number was considered satisfactory for the systematization and analysis of the data, when the KMO value was analyzed.

RESUMEN: Este estudio versa sobre la validación de un cuestionario aplicado a estudiantes de primer y último año de las licenciaturas en Biología, Ciencias, Física, Química y Pedagogía, para ello fueron seleccionadas dos diferentes instituciones para cada carrera. El instrumento de investigación pasó por una validación semántica, realizada por seis investigadores doctores de las áreas de Enseñanza (Biología, Física y Química), y la aplicación de una prueba piloto con estudiantes de la carrera de Biología. Después del análisis semántico y la prueba piloto, se eliminaron tres aserciones, y el cuestionario quedó constituido por 81 aserciones. Para evaluar la fiabilidad del instrumento (validación estadística), se realizó la prueba de Alpha de Cronbach, análisis factorial, Kaiser-Meyer-Olklin (KMO) y la prueba de esfericidad de Bartlett. Después de la aplicación de las pruebas, se eliminaron 30 aserciones, lo que hizo posible el Análisis de Componentes Principales (ACP). El número de muestreo fue considerado satisfactorio para la sistematización y análisis de los datos, cuando analizado el valor del KMO.

https://doi.org/10.1590/21172020210110 1719 downloads

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