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Abstract This study aimed to assess the influence of streptozotocin (STZ)-induced diabetes on the nociceptive behavior evoked by the injection of hypertonic saline (HS) into the masseter muscle of rats. Forty male rats were equally divided into four groups: a) isotonic saline control, which received 0.9% isotonic saline (IS), (Ctrl-IS); b) hypertonic saline control, which received 5% HS (Ctrl-HS); c) STZ-induced diabetic, which received IS, (STZ-IS); d) STZ-induced diabetic, which received HS (STZ-HS). Experimental diabetes was induced by a single intraperitoneal injection of STZ at dose of 60 mg/kg dissolved in 0.1 M citrate buffer, and 100 μL of HS or IS were injected into the left masseter to measure the nociceptive behavior. Later on, muscle RNA was extracted to measure the relative expression of the following cytokines: cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF-α), and interleukins (IL)-1β, -2, -6, and -10. One-way analysis of variance (ANOVA) was applied to the data (p < 0.050). We observed a main effect of group on the nociceptive response (ANOVA: F = 11.60, p < 0.001), where the Ctrl-HS group presented the highest response (p < 0.001). However, nociceptive response was similar among the Ctrl-IS, STZ-IS, and STZ-HS group (p > 0.050). In addition, the highest relative gene expression of TNF-α and IL-6 was found in the masseter of control rats following experimental muscle pain (p < 0.050). In conclusion, the loss of somatosensory function can be observed in deep orofacial tissues of STZ-induced diabetic rats. STZinduced (HS groups 09 0 9 0.9 , (IS) CtrlIS Ctrl (Ctrl-IS) b 5 CtrlHS (Ctrl-HS) c STZIS (STZ-IS) d STZHS. STZHS . (STZ-HS) 6 mgkg mg kg 01 1 0. buffer 10 cytokines cyclooxygenase2 cyclooxygenase 2 cyclooxygenase- COX2, COX2 COX (COX-2) TNFα, TNFα TNF α (TNF-α) IL1β, IL1β ILβ IL 1β, 1β β (IL)-1β 2, -2 6, -6 10. -10 Oneway One way ANOVA (ANOVA 0.050. 0050 0.050 050 0.050) 1160 11 11.60 0.001, 0001 0.001 001 0.001) 0.001. However CtrlIS, Ctrl-IS STZIS, STZ-IS addition IL6 IL- conclusion (IS (Ctrl-IS (Ctrl-HS (STZ-IS (STZ-HS (COX-2 (TNF-α - -1 005 0.05 05 116 11.6 000 0.00 00 (COX- 0.0 11. (COX

https://doi.org/10.1590/1807-3107bor-2024.vol38.0073

Click-evoked auditory brainstem response: The influence of age and risk factors for hearing loss Clickevoked Click evoked response
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Rocha, Josiana

; Resende, Luciana Macedo de

; Rezende, Ana Luiza de Freitas

; Valadares, Ana Carolina Andrade

; Ferreira, Daniella Bregunce Fernandes

; Carvalho, Sirley Alves da Silva

Revista CEFAC

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2024, Volume 26 N. 5 elocation e3924

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: analisar a relação entre os resultados dos Potenciais Evocados Auditivos de Tronco Encefálico e a idade gestacional corrigida de lactentes, considerando prematuridade e Indicadores de Risco para Deficiência Auditiva (IRDA). Métodos: estudo observacional transversal, composto por 62 lactentes, divididos em: G1 - 27 a 36 semanas e G2 - 37 a 41 semanas. Após resultado normal na TAN, foi realizado o PEATE por clique para pesquisa de integridade das vias auditivas e de limiar eletrofisiológico. Os dados foram analisados por meio de estatística descritiva, de associação amparada pelo teste Mann-Whitney e de correlação entre limiar eletrofisiológico e idade gestacional corrigida por meio do teste Spearman. O nível de significância adotado foi de 5% e intervalos de confiança de 95%. Resultados: os dois grupos apresentaram valores de latências absolutas e intervalos interpicos sem diferença estatisticamente significante na pesquisa de integridade de vias auditivas. Na pesquisa de limiar eletrofisiológico, foi observada diferença com relevância estatística entre G1 e G2. Na relação entre limiar eletrofisiológico e presença de IRDA e limiar eletrofisiológico com prematuridade também foi observada diferença com relevância estatística. Houve correlação fraca entre limiar eletrofisiológico e idade gestacional corrigida. Conclusão: conclui-se que, na população avaliada, os parâmetros de latência absoluta e os intervalos interpicos não foram influenciados pela idade gestacional corrigida. Entretanto, o limiar eletrofisiológico foi melhor no grupo com idade gestacional corrigida superior a 37 semanas. Pode-se também observar que a presença de indicadores de risco para a deficiência auditiva contribuiu para o aumento do limiar eletrofisiológico. Objetivo lactentes IRDA. . (IRDA) Métodos transversal 6 em G 2 3 4 TAN descritiva MannWhitney Mann Whitney Spearman 5 95 95% Resultados Conclusão concluise conclui se avaliada Entretanto Podese Pode (IRDA 9

ABSTRACT Purpose: to analyze the relationship between infants’ auditory brainstem response results and their corrected gestational age, considering prematurity and risk factors for hearing loss. Methods: a cross-sectional, observational study with 62 infants, divided into G1 (27 to 36 weeks) and G2 (37 to 41 weeks). After normal NHS results, the click-evoked ABR investigated the integrity of the auditory pathways and the electrophysiological threshold. Data were analyzed using descriptive statistics, as well as the association with the Mann-Whitney test and the correlation between electrophysiological threshold and corrected gestational age using the Spearman’s test with a significance level of 5%. Results: neither group had statistically significant different absolute latency values and interpeak intervals in the auditory pathway integrity study. The electrophysiological threshold study found a statistically significant difference between G1 and G2. Likewise, the difference between the electrophysiological threshold and the presence of risk factors for hearing loss and between the electrophysiological threshold and prematurity was statically significant. The electrophysiological threshold was weakly correlated with the corrected gestational age. Conclusion: the corrected gestational age in the study population did not influence the absolute latency parameters and interpeak intervals. However, the electrophysiological threshold was better in the group whose corrected gestational age was 37 or more weeks. Moreover, the presence of risk factors for hearing loss helped increase the electrophysiological threshold. Purpose infants Methods crosssectional, crosssectional cross sectional, sectional cross-sectional 6 G 27 (2 3 weeks (3 4 . clickevoked click evoked statistics MannWhitney Mann Whitney Spearmans Spearman s 5 5% Results Likewise Conclusion However Moreover 2 (

https://doi.org/10.1590/1982-0216/20242653924

Sentimentos, reações e expectativas de mães de crianças nascidas com microcefalia pelo vírus zika Sentimentos
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Oliveira, Poliana Soares de

; Lamy, Zeni Carvalho

; Guimarães, Carolina Nívea Moreira

; Ferreira, Ruth Helena de Souza Britto

; Okoro, Rayssa Daiana Silveira

; Batista, Rosana Fernandes Lucena

; Lamy Filho, Fernando

Cadernos Saúde Coletiva

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2023, Volume 31 N. 4 elocation e31040210

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução: Em 2015, o Brasil foi afetado pela epidemia de microcefalia. As famílias atingidas vivenciaram uma doença desconhecida. Objetivo: Analisar sentimentos, reações e expectativas de mães de crianças nascidas com microcefalia pelo vírus Zika. Método: Abordagem qualitativa. Realizadas entrevistas estruturadas e semiestruturadas com 19 mães e uma bisavó. Análise de conteúdo na modalidade temática. Resultados: Os sentimentos descritos foram tristeza, medo, ansiedade e, algumas vezes, culpa. As reações relatadas foram choque, desespero, busca por informações, negação e, além disso, cada entrevistada vivenciou diferentes formas de aceitação. O luto do filho desejado foi um processo lento e doloroso. A maioria teve gestação não planejada, o que pareceu não ter influenciado nos sentimentos e reações provocados pelo diagnóstico dos filhos. As expectativas em relação ao futuro da criança envolveram medo da morte prematura e preocupações com o desenvolvimento motor, especialmente a incapacidade de andar e comer sozinho, levando à dependência. Conclusões: Diante do nascimento de um filho com microcefalia, as mães precisaram refazer seus planos à luz de uma nova realidade, que impactou na qualidade de vida. Os profissionais precisam estar preparados para lidar com tais questões, garantindo também atenção às mães. Introdução 2015 desconhecida Objetivo Zika Método qualitativa 1 bisavó temática Resultados tristeza vezes culpa choque desespero informações disso aceitação doloroso planejada filhos motor sozinho dependência Conclusões realidade vida questões 201 20 2

Abstract Background: In 2015, Brazil was affected by the microcephaly epidemic, when affected families experienced an unknown disease. Objective: To analyze the feelings, reactions, and expectations of mothers of children born with microcephaly due to the Zika virus. Method: Qualitative approach. Structured and semi-structured interviews were conducted with 19 mothers and a great-grandmother. Content analysis in thematic modality. Results: The feelings described were sadness, fear, anxiety and, sometimes, guilt. The reactions reported were shock, despair, search for information, denial, and each interviewee experienced different forms of acceptance. Grieving the desired child was a slow and painful process. Most had unplanned pregnancies, which did not seem to have influenced the feelings and reactions caused by the children's diagnosis. Expectations regarding the child's future involved fear of premature death, concerns about motor development, especially the inability to walk and eat alone, leading to dependence. Conclusion: Given the birth of a child with microcephaly, mothers needed to redo their plans in the light of a new reality, which impacted on their quality of life. Professionals need to be prepared to deal with such issues while also ensuring attention to mothers. Background 2015 epidemic disease Objective virus Method approach semistructured semi structured 1 greatgrandmother. greatgrandmother great grandmother. grandmother great-grandmother modality Results sadness sometimes guilt shock despair information denial acceptance process pregnancies childrens s diagnosis childs death development alone dependence Conclusion reality life 201 20 2

https://doi.org/10.1590/1414-462x202331040210

The SISBIOTA-Diptera Brazilian Network: A long-term survey of Diptera from unexplored Brazilian Western Arc of Amazon, Cerrado, and Pantanal SISBIOTADiptera SISBIOTA Network longterm long term Amazon Cerrado
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Lamas, Carlos José Einicker

; Fachin, Diego Aguilar

; Falaschi, Rafaela Lopes

; Alcantara, Daniel Máximo Correa de

; Ale-Rocha, Rosaly

; Amorim, Dalton de Souza

; Araújo, Maíra Xavier

; Ascendino, Sharlene

; Baldassio, Letícia

; Bellodi, Carolina Ferraz

; Bravo, Freddy

; Calhau, Julia

; Capellari, Renato Soares

; Carmo-Neto, Antonio Marcelino do

; Cegolin, Bianca Melo

; Couri, Márcia Souto

; Carvalho, Claudio José Barros de

; Dios, Rodrigo de Vilhena Perez

; Falcon, Aida Vanessa Gomez

; Fusari, Livia Maria

; Garcia, Carolina de Almeida

; Gil-Azevedo, Leonardo Henrique

; Gomes, Marina Morim

; Graciolli, Gustavo

; Gudin, Filipe Macedo

; Henriques, Augusto Loureiro

; Krolow, Tiago Kütter

; Mendes, Luanna Layla

; Limeira-de-Oliveira, Francisco

; Maia, Valéria Cid

; Marinoni, Luciane

; Mello, Ramon Luciano

; Mello-Patiu, Cátia Antunes de

; Morales, Mírian Nunes

; Oliveira, Sarah Siqueira

; Patiu, Claudemir

; Proença, Barbara

; Pujol-Luz, Cristiane Vieira de Assis

; Pujol-Luz, José Roberto

; Rafael, José Albertino

; Riccardi, Paula Raile

; Rodrigues, João Paulo Vinicios

; Roque, Fabio de Oliveira

; Sallum, Maria Anice Mureb

; Santis, Marcelo Domingos de

; Santos, Charles Morphy Dias dos

; Santos, Josenilson Rodrigues dos

; Savaris, Marcoandre

; Shimabukuro, Paloma Helena Fernandes

; Silva, Vera Cristina

; Schelesky-Prado, Daniel de Castro

; Silva-Neto, Alberto Moreira da

; Camargo, Alexssandro

; Sousa, Viviane Rodrigues de

; Urso-Guimarães, Maria Virginia

; Wiedenbrug, Sofia

; Yamaguchi, Carolina

; Nihei, Silvio Shigueo

Revista Brasileira de Entomologia

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2023, Volume 67 N. 4 elocation e20230051

Abstract: En | Text: En | PDF: En

ABSTRACT The SISBIOTA-BRASIL was a three-year multimillion-dollar research program of the Brazilian government to document plants and animals in endangered/understudied areas and biomes in Brazil. Distributional patterns and the historical events that generated them are extensively unknown regarding Brazilian fauna and flora. This deficiency hinders the development of conservation policies and the understanding of evolutionary processes. Conservation decisions depend on precise knowledge of the taxonomy and geographic distribution of species. Given such a premise, we proposed to research the diversity of Diptera of the Brazilian western arc of Amazon, Cerrado, and Pantanal in the states of Mato Grosso, Mato Grosso do Sul, and Rondônia. Three important biomes of the South American continent characterize these Brazilian states: Amazon forest, Cerrado (Brazilian Savannah), and Pantanal. Besides their ecological relevance, these biomes historically lack intensive entomological surveys. Therefore, they are much underrepresented in the Brazilian natural history collections and in the scientific literature, which is further aggravated by the fact that these areas are being exponentially and rapidly converted to commercial lands. Our project involved over 90 collaborators from 24 different Brazilian institutions and one from Colombia among researchers, postdocs, graduate and undergraduate students, and technicians. We processed and analyzed nearly 300,000 specimens from ~60 families of Diptera collected with a large variety of methods in the sampled areas. Here, we provide a detailed overview of the genera and species diversity of 41 families treated. Our results point to a total of 2,130 species and 514 genera compiled and identified for the three states altogether, with an increase of 41% and 29% in the numbers of species and genera known for the three states combined, respectively. Overall, the 10 most species-rich families were Tachinidae, Cecidomyiidae, Tabanidae, Psychodidae, Sarcophagidae, Stratiomyidae, Bombyliidae, Syrphidae, Tephritidae, and Asilidae. The 10 most diverse in the number of genera were Tachinidae, Stratiomyidae, Asilidae, Mycetophilidae, Syrphidae, Tabanidae, Muscidae, Dolichopodidae, Sarcophagidae, and Chloropidae. So far, 111 scientific papers were published regarding taxonomic, phylogenetic, and biogeographical aspects of the studied families, with the description of 101 new species and three new genera. We expect that additional publications will result from this investigation because several specimens are now curated and being researched by specialists. SISBIOTABRASIL SISBIOTA BRASIL threeyear year multimilliondollar multimillion dollar endangeredunderstudied endangered understudied Brazil flora processes premise Sul Rondônia forest Savannah, Savannah , Savannah) relevance surveys Therefore literature lands 9 2 researchers postdocs students technicians 300000 300 000 300,00 60 ~6 Here 4 treated 2130 130 2,13 51 altogether 29 combined respectively Overall 1 speciesrich rich Tachinidae Cecidomyiidae Tabanidae Psychodidae Sarcophagidae Stratiomyidae Bombyliidae Syrphidae Tephritidae Asilidae Mycetophilidae Muscidae Dolichopodidae Chloropidae far 11 taxonomic phylogenetic specialists 30000 30 00 300,0 6 ~ 213 13 2,1 5 3000 3 0 300, 21 2,

https://doi.org/10.1590/1806-9665-rbent-2023-0051

Economic burden of respiratory syncytial and parainfluenza viruses in children of upper-middle-income countries: a systematic review uppermiddleincome upper middle income countries
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Rocha Filho, César Ramos

; Ramalho, Gabriel Sodré

; Martins, Johnny Wallef Leite

; Lucchetta, Rosa Camila

; Pinto, Ana Carolina Pereira Nunes

; Rocha, Aline Pereira da

; Trevisani, Giulia Fernandes Moça

; Reis, Felipe Sebastião de Assis

; Ferla, Laura Jantsch

; Mastroianni, Patrícia de Carvalho

; Correa, Luci

; Saconato, Humberto

; Trevisani, Virgínia Fernandes Moça

Jornal de Pediatria

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2023, Volume 99 N. 6 Pages 537 - 545

Abstract: En | Text: En | PDF: En

Abstract Objective: To identify and assess the current evidence available about the costs of managing hospitalized pediatric patients diagnosed with Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3) in upper-middle-income countries. Methods: The authors conducted a systematic review across seven key databases from database inception to July 2022. Costs extracted were converted into 2022 International Dollars using the Purchasing Power Parity-adjusted. PROSPERO identifier: CRD42020225757. Results: No eligible study for PIV3 was recovered. For RSV, cost analysis and COI studies were performed for populations in Colombia, China, Malaysia, and Mexico. Comparing the total economic impact, the lowest cost per patient at the pediatric ward was observed in Malaysia ($ 347.60), while the highest was in Colombia ($ 709.66). On the other hand, at pediatric ICU, the lowest cost was observed in China ($ 1068.26), while the highest was in Mexico ($ 3815.56). Although there is no consensus on the major cost driver, all included studies described that the medications (treatment) consumed over 30% of the total cost. A high rate of inappropriate prescription drugs was observed. Conclusion: The present study highlighted how RSV infection represents a substantial economic burden to health care systems and to society. The findings of the included studies suggest a possible association between baseline risk status and expenditures. Moreover, it was observed that an important amount of the cost is destinated to treatments that have no evidence or support in most clinical practice guidelines. Objective (RSV PIV (PIV3 uppermiddleincome upper middle income countries Methods 202 Parityadjusted. Parityadjusted Parity adjusted. adjusted Parity-adjusted identifier CRD42020225757 CRD Results recovered impact $ ( 347.60, 34760 347.60 , 347 60 347.60) 709.66. 70966 709.66 . 709 66 709.66) hand ICU 1068.26, 106826 1068.26 1068 26 1068.26) 3815.56. 381556 3815.56 3815 56 3815.56) driver treatment (treatment 30 Conclusion society expenditures Moreover guidelines (PIV 20 CRD4202022575 3476 347.6 34 6 7096 709.6 70 10682 1068.2 106 2 38155 3815.5 381 5 CRD420202257 347. 709. 7 1068. 10 3815. 38 CRD42020225 1 CRD4202022 CRD420202 CRD42020 CRD4202 CRD420 CRD42 CRD4

https://doi.org/10.1016/j.jped.2023.05.003

Birth weight and bone mineral density at 18–19 years: birth cohort 1997–1998 1819 18 19 18–1 years 19971998 1997 1998 1997–199 181 1 18– 1997199 199 1997–19 199719 1997–1 19971 1997–
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Araújo, Allanne Pereira

; Barbosa, Janaina Maiana Abreu

; Carvalho, Carolina Abreu de

; Viola, Poliana Cristina de Almeida Fonseca

; Ribeiro, Cecilia Claudia Costa

; Batista, Rosangela Fernandes Lucena

; Simões, Vanda Maria Ferreira

Revista de Saúde Pública

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2023, Volume 57 elocation 9

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO Analisar a associação entre o peso ao nascer e a densidade mineral óssea (DMO) na adolescência. MÉTODOS Estudo de coorte de nascimentos em São Luís, Maranhão, utilizando dados de dois momentos: ao nascimento e aos 18–19 anos. A exposição foi o peso ao nascer em gramas, analisado de forma contínua. O desfecho foi a DMO, utilizando o índice Z-escore (corpo inteiro) medido pela densitometria por dupla emissão de raios X (DEXA). Foi construído modelo teórico em gráficos acíclicos direcionados para identificar o conjunto mínimo de variáveis de ajuste – renda familiar, a mãe saber ler e escrever à época do nascimento, realização de pré-natal, tabagismo durante a gestação e paridade – para avaliar a associação entre o peso ao nascer e a densidade mineral óssea na adolescência. Utilizou-se regressão linear múltipla no software Stata 14.0. O nível de significância adotado foi de 5%. RESULTADOS Dos 2.112 adolescentes, 8,2% apresentaram baixo peso ao nascer e 2,8% apresentaram DMO considerada baixa para a idade. O Z-escore médio de corpo inteiro foi de 0,19 (± 1,00). O maior peso ao nascer foi associado de forma linear e direta aos valores de DMO na adolescência (Coef.: 0,10; IC95% 0,02–0,18), mesmo após ajuste para as variáveis renda familiar (Coef.: -0,33; IC95% -0,66–0,33) e a mãe saber ler e escrever (Coef.: 0,23; IC95% 0,03–0,43). CONCLUSÕES Apesar de a associação ter sido atenuada após ajuste das variáveis, o peso ao nascer está associado de forma positiva e linear à DMO na adolescência. (DMO Luís Maranhão momentos 1819 18 19 18–1 anos gramas contínua Zescore Z escore DEXA. DEXA . (DEXA) prénatal, prénatal pré natal, natal pré-natal Utilizouse Utilizou se 140 14 0 14.0 5 5% 2112 2 112 2.11 adolescentes 82 8 8,2 28 2,8 idade 019 0,1 ± ( 1,00. 100 1,00 1 00 1,00) Coef. Coef (Coef. 0,10 010 10 IC95 IC 0,02–0,18, 002018 0,02–0,18 , 02 0,02–0,18) 0,33 033 33 -0,33 0,66–0,33 066033 66 -0,66–0,33 0,23 023 23 0,03–0,43. 003043 0,03–0,43 03 43 0,03–0,43) 181 18– (DEXA 14. 211 11 2.1 8, 2, 01 0, 1,0 (Coef IC9 00201 0,02–0,1 0,3 3 -0,3 0,66–0,3 06603 6 -0,66–0,3 0,2 00304 0,03–0,4 4 21 2. 1, 0020 0,02–0, -0, 0,66–0, 0660 -0,66–0, 0030 0,03–0, 002 0,02–0 -0 0,66–0 066 -0,66–0 003 0,03–0 0,02– - 0,66– 06 -0,66– 0,03– 0,02 0,66 -0,66 0,03 0,0 0,6 -0,6

ABSTRACT OBJECTIVE To analyze the association between birth weight and bone mineral density (BMD) in adolescence. METHODS A birth cohort study in São Luís, Maranhão, using data from two moments: at birth and at 18–19 years. Exposure was the birth weight in grams, continuously analyzed. The outcome was BMD, using the Z-score index (whole body) measured by double X-ray densitometry (Dexa). A theoretical model was constructed in acyclic graphs to identify the minimum set of adjustment variables – household income, the mother knowing how to read and write at the time of birth, prenatal care, tobacco use during pregnancy, and parity — to evaluate the association between birth weight and bone mineral density in adolescence. Multiple linear regression was used in Stata 14.0 software. A 5% significance level was adopted. RESULTS From 2,112 adolescents, 8.2% had low birth weight and 2.8% had a low BMD for their age. The mean full-body Z-score was 0.19 (± 1.00). The highest birth weight was directly and linearly associated with BMD values in adolescence (Coef.: 0.10; 95%CI: 0.02–0.18), even after adjustment for the variables household income (Coef.: -0.33; 95%CI: -0.66–0.33) and the mother knowing how to read and write (Coef.: 0.23%; 95%CI: 0.03–0.43). CONCLUSION Although after adjusting the variables the association attenuated, birth weight positively and linearly relates to BMD in adolescence. (BMD Luís Maranhão moments 1819 18 19 18–1 years grams analyzed Zscore Z score whole body Xray X ray Dexa. Dexa . (Dexa) care pregnancy 140 14 0 14. software 5 adopted 2112 2 112 2,11 adolescents 82 8 8.2 28 2.8 age fullbody full 019 0.1 ± ( 1.00. 100 1.00 1 00 1.00) Coef. Coef (Coef. 0.10 010 10 95%CI 95CI CI 95 0.02–0.18, 002018 0.02–0.18 , 02 0.02–0.18) 0.33 033 33 -0.33 0.66–0.33 066033 66 -0.66–0.33 0.23% 023 23 0.03–0.43. 003043 0.03–0.43 03 43 0.03–0.43) attenuated 181 18– (Dexa 211 11 2,1 8. 2. 01 0. 1.0 (Coef 9 00201 0.02–0.1 0.3 3 -0.3 0.66–0.3 06603 6 -0.66–0.3 0.23 00304 0.03–0.4 4 21 2, 1. 0020 0.02–0. -0. 0.66–0. 0660 -0.66–0. 0.2 0030 0.03–0. 002 0.02–0 -0 0.66–0 066 -0.66–0 003 0.03–0 0.02– - 0.66– 06 -0.66– 0.03– 0.02 0.66 -0.66 0.03 0.0 0.6 -0.6

https://doi.org/10.11606/s1518-8787.2023057004179

Birth weight and bone mineral density at 18–19 years: birth cohort 1997–1998
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Araújo, Allanne Pereira

; Barbosa, Janaina Maiana Abreu

; Carvalho, Carolina Abreu de

; Viola, Poliana Cristina de Almeida Fonseca

; Ribeiro, Cecilia Claudia Costa

; Batista, Rosangela Fernandes Lucena

; Simões, Vanda Maria Ferreira

Revista de Saúde Pública

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2023, Volume 57 elocation 9

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.11606/s1518-8787.2023057004179

Chronic urticaria: profile from a reference center
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Fernandes de Souza, Ana Carolina Miranda Carvalho Ferreira

; Dortas Junior, Sérgio D.

; Azizi, Guilherme Gomes

; França, Alfeu Tavares

; Lupi, Omar

; Valle, Solange O.R.

Anais Brasileiros de Dermatologia

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aug 2022, Volume 97 N. 4 Pages 511 - 512

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.abd.2021.01.006

A randomized clinical trial on inhaled ciclesonide for managing acute asthma in the emergency room
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Martins, Demétrius Tierno

; Carlos, Karla

; Carvalho, Luciane Bizari

; Prado, Lucila Bizari

; Fransolin, Carolina

; Atallah, Alvaro Nagib

; Prado, Gilmar Fernandes do

Sao Paulo Medical Journal

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jun 2022, Volume 140 N. 3 Pages 430 - 438

Abstract: En | Text: En | PDF: En

ABSTRACT BACKGROUND: Use of inhaled corticosteroids for managing acute asthma exacerbations has been tested since the 1990s. OBJECTIVE: To compare high doses of inhaled ciclesonide with systemic hydrocortisone for managing acute asthma exacerbations in the emergency department. DESIGN AND SETTING: Double-blind, randomized clinical trial in the public healthcare system of the city of São Paulo. METHODS: Fifty-eight patients with moderate or severe asthma with peak flow < 50% of predicted were randomized into two groups. Over the course of four hours, one group received 1440 mcg of inhaled ciclesonide plus hydrocortisone-identical placebo (ciclesonide + placebo), while the other received 500 mg of intravenous hydrocortisone plus ciclesonide-identical placebo (hydrocortisone + placebo). Both groups received short-acting bronchodilators (fenoterol hydrobromide and ipratropium bromide). The research protocol included spirometry, clinical evaluation, vital signs and electrocardiogram monitoring. Data were obtained at 30 (baseline), 60, 90, 120, 180, and 240 minutes. We compared data from baseline to hour 4, between and within groups. RESULTS: Overall, 31 patients received ciclesonide + placebo and 27 received hydrocortisone + placebo. Inhaled ciclesonide was as effective as intravenous hydrocortisone for improving clinical parameters (Borg-scored dyspnea, P = 0.95; sternocleidomastoid muscle use, P = 0.55; wheezing, P = 0.55; respiratory effort, P = 0.95); and spirometric parameters (forced vital capacity, P = 0.50; forced expiratory volume in the first second, P = 0.83; peak expiratory flow, P = 0.51). CONCLUSIONS: Inhaled ciclesonide was not inferior to systemic hydrocortisone for managing acute asthma exacerbations, and it improved both clinical and spirometric parameters. TRIAL REGISTRATION: RBR-6XWC26 - Registro Brasileiro de Ensaios Clínicos (http://www.ensaiosclinicos.gov.br/rg/RBR-6xwc26/).

https://doi.org/10.1590/1516-3180.2021.0542.r1.15092021

10.

Fatores associados à mortalidade perinatal em uma capital do Nordeste brasileiro
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Serra, Sara Costa

; Carvalho, Carolina Abreu de

; Batista, Rosangela Fernandes Lucena

; Thomaz, Erika Bárbara Abreu Fonseca

; Viola, Poliana Cristina de Almeida Fonseca

; Silva, Antônio Augusto Moura da

; Simões, Vanda Maria Ferreira

Ciência & Saúde Coletiva

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apr 2022, Volume 27 N. 4 Pages 1513 - 1524

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo do estudo foi avaliar os fatores sociodemográficos, maternos e do recém-nascido associados à mortalidade perinatal em São Luís, Maranhão. Os óbitos perinatais foram identificados na coorte e pelo Sistema de Informações sobre Mortalidade. Foram incluídos 5.236 nascimentos, sendo 70 óbitos fetais e 36 neonatais precoces. Para investigar os fatores associados utilizou-se análise de regressão logística com modelo hierarquizado. O coeficiente de mortalidade perinatal foi 20,2 por mil nascimentos. A baixa escolaridade materna e a ausência de companheiro foram associadas a maior chance de óbito perinatal. A família ser chefiada por outros familiares foi fator de proteção. Tiveram maior chance de óbito perinatal filhos de mães que não realizaram pelo menos seis consultas de pré-natal (OR=4,61; IC95%:2,43-8,74) e com gravidez múltipla (OR=9,15; IC95%:4,08-20,53). Presença de malformações congênitas (OR=4,13; IC95%:1,23-13,82), nascimento pré-termo (OR= 3,36; IC95%: 1,56-7,22) e baixo peso ao nascer (BPN) (OR=11,87; IC95%:5,46-25,82) se associaram ao óbito perinatal. A mortalidade perinatal foi associada à vulnerabilidade social, não realização do número de consultas pré-natal recomendado, malformações congênitas, nascimento pré-termo e BPN.

Abstract This study investigated factors associated with perinatal mortality in São Luís, Maranhão, Northeastern Brazil. Data on perinatal mortality were obtained from the BRISA birth cohort and from the Mortality Information System, including records of 5,236 births, 70 of which referred to fetal deaths and 36 to early neonatal deaths. Factors associated with mortality were investigated using a hierarchical logistic regression model, resulting in a perinatal mortality coefficient equal to 20.2 per thousand births. Mothers with low education level and without a partner were associated with an increased risk of perinatal death. Moreover, children of mothers who did not have at least six antenatal appointments and with multiple pregnancies (OR= 9.15; 95%CI:4.08-20.53) were more likely to have perinatal death. Perinatal death was also associated with the presence of congenital malformations (OR= 4.13; 95%CI:1.23-13.82), preterm birth (OR= 3.36; 95%CI:1.56-7.22), and low birth weight (OR=11.87; 95%CI:5.46-25.82). In turn, families headed by other family members (OR= 0.29; 95%CI: 0.12 - 0.67) comprised a protective factor for such condition. Thus, the results indicate an association between perinatal mortality and social vulnerability, non-compliance with the recommended number of prenatal appointments, congenital malformations, preterm birth, and low birthweight.

https://doi.org/10.1590/1413-81232022274.07882021

11.

Fatores associados à mortalidade perinatal em uma capital do Nordeste brasileiro
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Serra, Sara Costa

; Carvalho, Carolina Abreu de

; Batista, Rosangela Fernandes Lucena

; Thomaz, Erika Bárbara Abreu Fonseca

; Viola, Poliana Cristina de Almeida Fonseca

; Silva, Antônio Augusto Moura da

; Simões, Vanda Maria Ferreira

Ciência & Saúde Coletiva

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apr 2022, Volume 27 N. 4 Pages 1513 - 1524

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232022274.07882021

12.

Ambulation capacity, age, immunosuppression, and mechanical ventilation are risk factors of in-hospital death in severe COVID-19: a cohort study
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Silva, Erika Christina Gouveia e

; Schmitt, Ana Carolina Basso

; Godoy, Caroline Gil de

; Gambeta, Amislaine Cristina

; Carvalho, Celso Ricardo Fernandes de

; Fu, Carolina

; Tanaka, Clarice

; Toufen Junior, Carlos

; Carvalho, Carlos Roberto Ribeiro de

; Pompeu, José Eduardo

Clinics

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2022, Volume 77 elocation 100075

Abstract: En | Text: En | PDF: En

Abstract Importance: Despite ambulation capacity being associated with a decreased level of physical activity and survival may be influenced by the functional capacity, studies have not addressed the association between ambulation capacity and death in patients hospitalized by COVID-19. Objective: To verify the functional, clinical, and sociodemographic risk factors associated with in-hospital death in individuals with severe COVID-19. Methods: It is a cohort retrospective study performed at a large tertiary hospital. Patients 18 years of age or more, of both sexes, hospitalized due to severe COVID-19 were included. Cases with dubious medical records and/or missing essential data were excluded. Patients were classified according to their ambulation capacity before the COVID-19 infection. Information regarding sociodemographic characteristics, in-hospital death, total hospital stays, Intensive Care Unit (ICU) stays, and the necessity of Mechanical Ventilation (MV) were collected from medical records and registered in a RedCap database. Multiple logistic regression analysis was used to identify possible factors associated with the in-hospital death rate. Results: Data from 1110 participants were included in the statistical analysis. The median age of the patients was 57 (46‒66) years, 58.42% (n = 590) were male, and 61.73% (n = 602) were brown or black. The case fatality rate during hospitalization was 36.0% (n = 363). In-hospital death was associated with ambulation capacity; dependent ambulators (OR = 2.3; CI 95% = 1.2-4.4) and non-functional ambulation (OR = 1.9; CI 95% = 1.1-3.3), age [older adults (OR = 3.0; CI 95% = 1.9‒4.), ICU stays (OR = 1.4; CI 95% = 1.2‒1.4), immunosuppression (OR = 5.5 CI 95% = 2.3‒13.5) and mechanical ventilation (OR = 27.5; CI 95% = 12.0-62.9). Conclusion and relevance: Decreased ambulation capacity, age, length of ICU stay, immunosuppression, and mechanical ventilation was associated with a high risk of in-hospital death due to COVID-19.

https://doi.org/10.1016/j.clinsp.2022.100075

13.

Fragmentation effects on beta diversity of fragmented and conserved landscapes: insights about homogenization and differentiation processes
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Araújo, Felipe de Carvalho

; Mendes, Carolina Njaime

; Souza, Cleber Rodrigo de

; Miranda, Kaline Fernandes

; Morelli, Mariana Caroline Moreira

; Coelho, Polyanne Aparecida

; Figueiredo, Maria Auxiliadora Pereira

; Carvalho, Warley Augusto Caldas

; Castro, Gislene Carvalho de

; Fontes, Marco Aurélio Leite

; Santos, Rubens Manoel dos

Acta Botanica Brasilica

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2022, Volume 36 elocation e2020abb0261

Abstract: En | Text: En | PDF: En

ABSTRACT Fragmentation is one of the main causes of biodiversity loss in tropical forests through consequences on their different components. Beta diversity patterns across fragments have been studied across multiple spatial scales, but comparisons with intact landscapes and in a variety of vegetation types are scarce. In order to address this issue of anthropogenic landscape disturbance, we tested two hypotheses relating to fragmentation and beta diversity: 1. Floristic homogenization at patch-level scale and 2. Floristic differentiation at landscape-level scale. The study was conducted in the Espinhaço Range biosphere reserve, Brazil. Three landscapes encompassing a broad range of vegetation types were sampled in 115 plots. Two landscapes were fragmented due to mining activities (Sabará and Brumadinho) and one is protected (Parque Estadual Serra do Rola-Moça). Results showed high overall beta diversity both between landscapes (conserved and fragmented) and vegetation types (forest, Brazilian savanna “campos rupestres”, ecotone and ironstone “canga”) with high turnover and species losses, even in highly disturbed vegetation types. The conserved landscape was most diverse in terms of richness. Thus, fragmentation effects differed from the expected with a main role of differentiation processes, and we argue that high beta diversity is not always a good predictor of ecosystem health.

https://doi.org/10.1590/0102-33062020abb0261

14.

Síndrome congênita pelo vírus zika: análise das redes de apoio de pais
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Costa, Roama Paulo Ulisses Vaz da

; Lamy, Zeni Carvalho

; Oliveira, Poliana Soares de

; Carvalho, Ruth Helena de Souza Britto Ferreira de

; Pereira, Marina Uchoa Lopes

; Guimarães, Carolina Nívea Moreira

; Batista, Rosangela Fernandes Lucena

; Nascimento, Maria do Desterro Soares Brandão

Acta Paulista de Enfermagem

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2022, Volume 35 elocation eAPE02912

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Objetivo Compreender o papel das redes de apoio no cuidado de crianças acometidas pela Síndrome Congênita pelo Vírus Zika. Métodos Estudo qualitativo, realizado em Centro de Referência Estadual em Neurodesenvolvimento, no nordeste brasileiro, entre abril de 2017 e fevereiro de 2018. Participaram pais de crianças com microcefalia atendidos no local. Foram realizadas 18 entrevistas semiestruturadas, sendo três com pai e mãe e 15 somente com mães, totalizando 21 participantes. A amostra foi definida pelo critério de saturação e foi utilizada análise de conteúdo na modalidade temática. Resultados Os resultados são apresentados a partir das categorias de análise “rede informal” e “rede formal”. A rede de apoio informal, especialmente os avós, exerceu importante suporte emocional e financeiro aos pais. As redes sociais virtuais se destacaram como espaço de compartilhamento de informações e experiências. Quanto à rede de apoio formal, as famílias estabeleceram vínculos mais fortes com profissionais da atenção especializada que ofertaram suporte técnico e acolhimento aos pais e às crianças. Já a atenção primária desempenhou mais o papel de encaminhamento para a atenção especializada. Foram relatados diferentes graus de resolutividade por parte dos municípios, em termos de programas, de atuação de gestores e de profissionais. Conclusão As redes informais e formais atuaram de modo complementar no tratamento e apoio às crianças com Síndrome Congênita pelo Vírus Zika. A inserção em diferentes redes informais possibilitou apoio social para enfrentar o impacto provocado pela doença. Apesar do investimento do Ministério da Saúde na atenção primária foi identificada fragilidade neste nível de atenção.

Abstract Objective To understand the role of support networks in the care of children affected by Congenital Zika Syndrome. Methods This is a qualitative study, conducted at a State Reference Center on Neurodevelopment, in northeastern Brazil, between April 2017 and February 2018. Parents of children with microcephaly treated at the site participated. 18 semi-structured interviews were conducted, three with father and mother and 15 only with mothers, totaling 21 participants. The sample was defined by the saturation criterion and content analysis was used in the thematic modality. Results The results are presented from the categories of analysis “informal network” and “formal network”. The informal support network, especially grandparents, exercised important emotional and financial support to parents. Virtual social networks stood out as a space for sharing information and experiences. Regarding the formal support network, the families established stronger bonds with specialized care professionals who offered technical support and care to parents and children. Primary care, on the other, played the role of referral to specialized care. Different degrees of resolution were reported by the municipalities, in terms of programs, the performance of managers and professionals. Conclusion Formal and formal networks acted in a complementary way in the treatment and support of children with Congenital Zika Syndrome. The insertion in different indirect networks allowed social support to face the impact caused by the disease. Despite the ministry of health’s investment in primary care, fragility was identified in this level of care.

Resumen Objetivo Comprender el papel de las redes de apoyo en el cuidado de niños afectados por el síndrome congénito por el virus del zika. Métodos Estudio cualitativo, realizado en un Centro de Referencia Regional en Neurodesarrollo, en el nordeste brasileño, entre abril de 2017 y febrero de 2018. Participaron padres de niños con microcefalia atendidos en el lugar. Se realizaron 18 entrevistas semiestructuradas, de las cuales tres fueron con el padre y la madre y 15 solo con madres, un total de 21 participantes. La muestra fue definida por el criterio de saturación y se utilizó análisis de contenido en la modalidad temática. Resultados Los resultados se presentan a partir de las categorías de análisis “red informal” y “red formal”. La red de apoyo informal, especialmente los abuelos, ejerció un importante soporte emocional y financiero para los padres. Las redes sociales virtuales se destacaron como un espacio para compartir información y experiencias. Respecto a la red de apoyo formal, las familias establecieron vínculos más fuertes con profesionales de la atención especializada, que ofrecieron soporte técnico y acogida a los padres y a los niños. Por otro lado, la atención primaria cumplió más el papel de derivar a la atención especializada. Se relataron diferentes niveles de resolución de problemas por parte de los municipios, en términos de programas, de actuación de gestores y de profesionales. Conclusión Las redes informales y formales actuaron de modo complementario en el tratamiento y apoyo a niños con síndrome congénito por el virus del zika. La inserción en diferentes redes informales permitió un apoyo social para enfrentar el impacto provocado por la enfermedad. A pesar de las inversiones en atención primaria del Ministerio de Salud, se identificó fragilidad en este nivel de atención.

https://doi.org/10.37689/acta-ape/2022ao02912

15.

On probiotic yeasts in food development: Saccharomyces boulardii, a trend
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SOUZA, Handray Fernandes de

; CAROSIA, Mariana Fronja

; PINHEIRO, Carolina

; CARVALHO, Marina Vieira de

; OLIVEIRA, Carlos Augusto Fernandes de

; KAMIMURA, Eliana Setsuko

Food Science and Technology

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2022, Volume 42 elocation e92321

Abstract: En | Text: En | PDF: En

Abstract Studies conducted in the last decades have demonstrated the probiotic effects of several yeast species. Among the probiotic yeast evaluated, Saccharomyces boulardii is the most common and widely studied species with significant probiotic properties, such as survival capacity in the acidic environment of the gastrointestinal tract and improvements in the intestinal microbiota. In recent years, new evidence indicated that the incorporation of probiotic yeasts is also a promising approach in food development, thus leading to new perspectives for a more integrated strategy for a potential application of S. boulardii in the development of innovative functional food products. In this review, an overview of recent published data on the application of probiotic yeast in foods is presented, especially on the use of S. boulardii as a trend to develop several functional foods, such as non-alcoholic, fermented alcoholic, vegetable, and bakery products.

https://doi.org/10.1590/fst.92321

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