ABSTRACT Purpose: To compare biochemical recurrence, sexual potency and urinary continence outcomes of ablative therapy and radical treatment (radical prostatectomy or radiotherapy with androgen deprivation therapy). Material and methods: A systematic review and meta-analysis followed the PRISMA guidelines were performed. We searched MEDLINE/PubMed. Biochemical recurrence at three and five years; incontinence rate (patients who used one pad or more) and erectile dysfunction rate at 12 and 36 months (patients who did not have sufficient erection to achieve sexual intercourse) were evaluated. The Mantel-Haenszel method was applied to estimate the pooled risk difference (RD) in the individual studies for categorical variables. All results were presented as 95% confidence intervals (95%CI). Random effects models were used regardless of the level of heterogeneity (I²). (PROSPERO CRD42022296998). Results: Eight studies comprising 2,677 men with prostate cancer were included. There was no difference in biochemical recurrence between ablative and radical treatments. We observed the same biochemical recurrence between ablative therapy and radical treatment within five years (19.3% vs. 16.8%, respectively; RD 0.07; 95%CI=-0.05, 0.19; I2=68.2%; P=0.08) and continence rate at 12 months (9.2% vs. 31.8%, respectively; RD −0.13; 95%CI, −0.27, 0.01; I2=89%; P=0.32). When focal treatment was analyzed alone, two studies with 582 patients found higher erectile function at 12 months in the ablative therapy group than in the radical treatment (88.9% vs. 30.8%, respectively; RD −0.45; 95%CI −0.84, −0.05; I2=93%; P=0.03). Conclusion: Biochemical recurrence and urinary continence outcomes of ablative therapy and radical treatment were similar. Ablative therapy appears to have a high rate of sexual potency. Purpose therapy. . therapy) methods metaanalysis meta analysis performed MEDLINEPubMed MEDLINE PubMed MEDLINE/PubMed more 1 3 intercourse evaluated MantelHaenszel Mantel Haenszel (RD variables 95 95%CI. 95CI CI (95%CI) I². I² I (I²) PROSPERO CRD42022296998. CRD42022296998 CRD CRD42022296998) Results 2677 2 677 2,67 included treatments 19.3% 193 19 (19.3 vs 168 16 8 16.8% respectively 0.07 007 0 07 95%CI=0.05, 95CI005 95%CI= 0.05, 05 95%CI=-0.05 0.19 019 I2=68.2% I2682 I2 68 P=0.08 P008 P 08 9.2% 92 9 (9.2 318 31 31.8% −0.13 013 13 027 27 −0.27 0.01 001 01 I2=89% I289 89 P=0.32. P032 P=0.32 32 P=0.32) alone 58 88.9% 889 88 (88.9 308 30 30.8% −0.45 045 45 084 84 −0.84 −0.05 005 I2=93% I293 93 P=0.03. P003 P=0.03 03 P=0.03) Conclusion similar (95%CI (I² CRD4202229699 267 67 2,6 19.3 (19. 16.8 0.0 00 95%CI=0.05 95CI00 0.05 95%CI=-0.0 0.1 I2=68.2 I268 6 P=0.0 P00 9.2 (9. 31.8 −0.1 02 −0.2 I2=89 I28 P03 P=0.3 5 88.9 (88. 30.8 −0.4 04 4 −0.8 −0.0 I2=93 I29 (I CRD420222969 26 2, 19. (19 16. 0. 95%CI=0.0 95CI0 95%CI=-0. I2=68. I26 P=0. P0 9. (9 31. −0. I2=8 88. (88 30. I2=9 CRD42022296 (1 95%CI=0. 95%CI=-0 I2=68 P=0 ( −0 I2= (8 CRD4202229 95%CI=0 95%CI=- I2=6 P= − CRD420222 CRD42022 CRD4202 CRD420 CRD42 CRD4

ABSTRACT Objective: This study aims to evaluate aspirin as a chemical prophylaxis (200 mg) in total hip arthroplasty. Methods: the study compared two groups and used ultrasonography (USG) to screen for low-deep venous thrombosis. Group 1 received 600 mg (control), and Group 2 received 200 mg of (intervention), associated with the use of elastic compression stockings and early walking Results: fourteen patients were allocated to Group A (200mg), and 16 to Group B (600mg); in group A (200mg), 3 cases with thrombus below the popliteal vein were detected at the first USG examination. All of them are in the left lower limb (21.4%). In group B (600 mg), 5 cases were identified after the first exam (31.2%). All cases were asymptomatic and followed the protocol with prophylaxis only with Aspirin. Conclusion: In the statistical data, there were no differences in the presence of thrombus between the 200- and 600 mg groups, which is credited to using low-dose aspirin in low doses (200mg). Hematimetric levels returned to baseline levels and suggested there was no chronic or acute bleeding related to the use of aspirin. The manuscript was prepared according to the CONSORT guideline 2010. Level of Evidence I; Longitudinal Randomized Comparative Clinical Study. Objective (20 arthroplasty Methods (USG lowdeep deep thrombosis 60 control, control , (control) 20 intervention, intervention (intervention) Results 200mg, 200mg (200mg) 600mg (600mg) examination 21.4%. 214 21.4% . 21 4 (21.4%) (60 mg, 31.2%. 312 31.2% 31 (31.2%) Aspirin Conclusion data lowdose dose 200mg. 2010 I Study (2 6 (control (intervention (200mg (600mg 21.4 (21.4% (6 31.2 (31.2% 201 ( 21. (21.4 31. (31.2 (21. (31. (21 (31 (3

RESUMO Objetivo: Este estudo pretende avaliar a aspirina como profilaxia química (200 mg) na artroplastia total do quadril. Métodos: estudo comparando dois grupos com diferentes doses de aspirina e utilizando a ultrassonografia (USG) para rastreamento da trombose venosa profunda baixa. O grupo 1, 650 mg ao dia de aspirina (controle) e o grupo 2, 200 mg de aspirina ao dia na mesma posologia (intervenção) e associados ao uso de meias elásticas de compressão e deambulação precoce. Resultados: quatorze pacientes foram alocados no grupo A (200 mg) e 16 no grupo B (650 mg). No grupo A foram detectados 3 casos com trombos abaixo da veia poplítea ao USG sendo 21,4%. Já no grupo B, 5 casos foram identificados após o primeiro exame (31,2%). Todos assintomáticos e sem sinais de sangramento ativo ou queda da hematimetria no momento da detecção dos trombos. Conclusão: os dados sugerem não haver diferença na incidência de trombo em ambos os grupos, não sendo a profilaxia com a aspirina dose-dependente. Os níveis hematimétricos retornaram aos níveis iniciais o que sugere não ter havido sangramento crônico ou agudo relacionado ao uso. Nível de Evidência I; Estudo Clínico Randomizado Longitudinal Comparativo. Objetivo (20 quadril Métodos (USG baixa 1 65 controle (controle 2 20 intervenção (intervenção precoce Resultados (65 mg. . 214 21 4 21,4% 31,2%. 312 31,2% 31 (31,2%) Conclusão dosedependente. dosedependente dose dependente. dependente dose-dependente I Comparativo (2 6 (6 21,4 31,2 (31,2% ( 21, 31, (31,2 (31, (31 (3

Abstract Objective Despite some knowledge gaps in scientific evidence, MgCl2 is largely used for pain relief in musculoskeletal diseases. Mg salts were shown to provide analgesia postoperatively in orthopedic surgery and low Mg levels were linked to arthritis development and severity. We determined the anti-inflammatory activity of MgCl2 in an acute arthritis model. Methods Mice received 0.1 mg/25μL Zymosan (Zy) or saline into the knees. Joint pain was evaluated using von Frey test; cell influx, and interleukin (IL)-1 level were assessed in joint lavage at 6 h. Synovia were excised for histopathology and analysis of immunoexpression of nuclear factor kappa B (NFκB) and tumor necrosis factor (TNF)-α. Groups (n = 6/group) received either 90 mg/kg MgCl2/100 μL or saline per os (systemic) or 500 μg/25 μL MgCl2 or saline intra-articularly (i.a.) 30 min prior to Zy. Results MgCl2 given either systemically or locally significantly reduced cell influx (p = 0.0012 and p = 0.0269, respectively), pain (p = 0.0005 and p = 0.0038, respectively), and intra-articular IL-1 level (p = 0.0391), as compared to saline. Systemic MgCl2 significantly decreased NFκB (p < 0.05) immmunoexpression, as compared to saline. Conclusion MgCl2 given systemically or locally displayed anti-inflammatory activity in a severe acute arthritis model reducing cell influx, pain, and cytokine release. MgCl2 operates at least partially via inhibiting NFκB activation. This is the first in vivo demonstration that MgCl2 decreases cytokine release in arthritis, prompting reduction of inflammation and pain relief. evidence MgCl diseases severity antiinflammatory anti inflammatory 01 0 1 0. mg25μL mgμL mg 25μL Zy (Zy knees test IL1 IL (IL)- h (NFκB TNFα. TNFα TNF α. α (TNF)-α n 6/group 6group group 9 mgkg kg MgCl2100 100 MgCl2/10 systemic (systemic 50 μg25 μg 25 μg/2 intraarticularly intra articularly i.a. ia i (i.a. 3 00012 0012 0.001 00269 0269 0.0269 respectively, respectively , respectively) 00005 0005 0.000 00038 0038 0.0038 intraarticular articular IL- 0.0391, 00391 0.0391 0391 0.0391) 0.05 005 05 immmunoexpression activation (IL) MgCl210 10 MgCl2/1 5 μg2 2 μg/ i.a (i.a 0001 001 0.00 0026 026 0.026 0000 000 0003 003 0.003 0039 0.039 039 0.0 00 (IL MgCl21 MgCl2/ 002 02 0.02 0.03 03

Abstract This systematic review aimed to answer the focused question: “What are the benefits of subgingival periodontal therapy on blood hematological and biochemical index, biomarkers of inflammation and oxidative stress, quality of life, and periodontal pathogen counts in patients with obesity and periodontitis?”. A systematic literature search was performed in six databases: PubMed, Embase, LILACS, Web of Science, Cochrane and SCOPUS and other sources, and a manual search was conducted as well. Inclusion criteria were randomized and non-randomized clinical trials, and before-and-after studies on patients with obesity subjected to periodontal therapy. The results were synthesized qualitatively. Risk of bias within studies was assessed using RoB 2 and ROBINS-I tools. The certainty of evidence was evaluated following the GRADE approach. Three randomized controlled trials and 15 before-and-after studies were included. Randomized controlled trials were considered to have a low risk of bias, as compared to before-and-after studies assessed as having low, serious, and critical risks of bias. Non-surgical periodontal therapy plus azithromycin, chlorhexidine, and cetylpyridinium chloride reduced blood pressure and decreased serum levels of HbA1c, hsCRP, IL-1β, and TNF-α. Salivary resistin level also decreased in patients with obesity and periodontitis after therapy and chlorhexidine mouth rinse. Before-and-after data suggest an improvement in total cholesterol, LDL, triglycerides, insulin resistance, C3, GCF levels of TNF-α, chemerin, vaspin, omentin-1, visfatin, 8-OHdG, and periodontal pathogen counts after therapy. question What index stress life periodontitis. . periodontitis?” databases PubMed Embase LILACS Science sources well nonrandomized non beforeandafter before qualitatively ROBINSI ROBINS I tools approach 1 included serious Nonsurgical Non surgical azithromycin HbA1c HbAc HbA c hsCRP IL1β, IL1β ILβ IL 1β, 1β β IL-1β TNFα. TNFα TNF α. α TNF-α rinse Beforeandafter Before cholesterol LDL triglycerides resistance C3 C TNFα, α, chemerin vaspin omentin1, omentin1 omentin 1, omentin-1 visfatin 8OHdG, 8OHdG OHdG 8 OHdG, 8-OHdG periodontitis? omentin-

Abstract Pulmonary arterial hypertension (PAH) is characterized by right ventricular failure and diminished cardiac output, potentially leading to renal and bone impairments. In contrast, resistance exercise training (RT) offers cardiovascular and bone health benefits. This study aimed to assess the impacts of stable PAH induced by monocrotaline (MCT) and RT on renal morphometry, as well as bone morphometry and biomechanical properties in male Wistar rats. Four experimental groups, untrained control (UC, n=7), trained control (TC, n=7), untrained hypertensive (UH, n=7), trained hypertensive (TH, n=7), were defined. After the first MCT or saline injection (20 mg/kg), trained rats were submitted to a RT program (i.e., Ladder climbing), 5 times/week. Seven days later the rats received the second MCT or saline dose. After euthanasia, renal and femoral histomorphometry and femoral biomechanical properties were assessed. PAH reduced renal glomerular area and volume, which was prevented by the RT. While PAH did not harm the femoral morphometry, structural and mechanical properties, RT improved the femoral parameters (e.g., length, percentage of trabeculae and bone marrow, ultimte and yield loads). Experimental stable PAH promotes renal but not bone damages, whereas RT prevents renal deteriorations and improves the femoral morphological and biomechanical properties. (PAH output impairments contrast (RT benefits (MCT groups UC, UC (UC n=7, n7 n n=7 , 7 n=7) TC, TC (TC UH, UH (UH TH, TH (TH defined 20 (2 mg/kg, mgkg mg/kg mg kg mg/kg) i.e., ie i e (i.e. climbing, climbing climbing) timesweek times week times/week dose euthanasia assessed volume e.g., eg g (e.g. length marrow loads. loads . loads) damages n= 2 ( i.e. (i.e e.g. (e.g i.e e.g

ABSTRACT. Although acerola (Malpighia emarginata DC.) is a tropical fruit of high interest due to its high ascorbic acid content and attractive sensory attributes, fruit production is characterized by high genetic variability. Additionally, the use of new biometric tools for acerola breeding is scarce. This study aimed to estimate genetic parameters and the coefficient of repeatability, as well as determine the optimal number of fruits for quality trait analyses in different acerola genotypes, using different approaches. Twenty-three (Experiment I) and thirty-five (Experiment II) genotypes were evaluated in a randomized block design with four replicates and three plants per plot. Twenty fruits per plant were harvested and evaluated for the following quality traits: diameter, mass, skin color (lightness, chroma and hue), firmness, soluble solids (SS), titratable acidity (TA), SS/TA ratio, and ascorbic acid content. The genetic parameters and the coefficient of repeatability were estimated for each experiment using classical and Bayesian methods. Both approaches achieved similar results on estimating variance components, genetic parameters and the coefficient of repeatability. Genetic parameters showed favorable conditions for acerola selection. The coefficient of repeatability was high for all acerola quality traits. A total of 17 fruits are required for the effective selection of acerola genotypes with an accuracy of 95%. ABSTRACT Malpighia DC. DC attributes variability Additionally scarce Twentythree Experiment I thirtyfive thirty five II plot traits diameter mass lightness, lightness (lightness hue, hue , hue) firmness SS, SS (SS) TA, TA (TA) SSTA ratio methods components 1 95 95% (SS (TA 9

ABSTRACT Objective: To assess the capacity to identify potential organ donors in a university hospital in Maranhão (MA). Methods: The study is a retrospective, quantitative cohort based on the documentary analysis of medical records of deceased patients in the adult intensive care units (ICUs) of a university hospital in MA from 2018 to 2019. Screening Instrument I from the Organización Nacional de Trasplantes (ONT) of Spain, based on Avedis Donabedian and validated in Brazil, was used to identify potential donors with clinical signs of brain death (BD). The analysis involved reviewing medical records and applying BD diagnostic criteria, according to Conselho Federal de Medicina Resolution nº 2,173 of 2017. A total of 312 records were analyzed, resulting in 38 with signs of BD, classified as escapes due to identification and maintenance failures of potential donors. Results: Of the 312 evaluated records, 21 from 2018 and 17 from 2019 (totaling 38) presented clinical signs of BD and were selected for detailed auditing.Additionally, it was identified that 31.1% of the escapes or losses of potential donors resulted from deaths not identified as BD, generating previously unknown indicators. The tool revealed that patients undergoing surgical treatment for brain tumors and cerebrovascular diseases have a higher likelihood of evolving to BD. These patients, usually admitted to the general ICU, should receive special attention in daily assessments due to their high potential to become organ donors. Conclusion: The audit highlighted the need for improvements in the identification and maintenance of potential donors, as well as in reducing family refusals, to increase the number of effective donations. Objective MA. . (MA) Methods retrospective ICUs (ICUs 201 ONT (ONT Spain Brazil (BD) criteria 2173 2 173 2,17 2017 31 analyzed 3 Results 1 totaling auditingAdditionally auditing Additionally auditing.Additionally 311 31.1 indicators ICU Conclusion refusals donations (MA 20 (BD 217 2,1 31. 2,

RESUMO Objetivo: Avaliar a capacidade de identificar possíveis doadores de órgãos em um hospital universitário no estado do Maranhão (MA). Métodos: O estudo é uma coorte retrospectiva, quantitativa, baseada na análise documental de prontuários de pacientes falecidos nas unidades de terapia intensiva (UTIs) de adultos de um hospital universitário no MA, no período de 2018 a 2019. Utilizou-se o Instrumento de Triagem I da Organización Nacional de Trasplantes (ONT) da Espanha, fundamentado por Avedis Donabedian e validado no Brasil, para identificar possíveis doadores com indícios clínicos de morte encefálica (ME). A análise envolveu a revisão dos prontuários e a aplicação de critérios de diagnóstico de ME, conforme a Resolução nº 2.173 de 2017 do Conselho Federal de Medicina. Foram analisados 312 prontuários, resultando em 38 com sinais de ME, classificados como escapes por falhas na identificação e manutenção dos doadores. Resultados: Dos 312 prontuários avaliados, 21 de 2018 e 17 de 2019 (totalizando 38) apresentaram indícios clínicos de ME e foram selecionados para auditoria detalhada. Além disso, foi identificado que 31,1% dos escapes ou perdas de possíveis doadores ocorreram devido a óbitos não identificados como ME, gerando indicadores antes desconhecidos. A ferramenta revelou que pacientes submetidos a tratamento cirúrgico para tumores encefálicos e doenças cerebrovasculares têm maior probabilidade de evoluir para ME. Esses pacientes, geralmente internados na UTI geral, devem receber atenção especial nas avaliações diárias, pois têm alto potencial para se tornarem doadores de órgãos. Conclusão: A auditoria evidenciou a necessidade de melhorias na identificação e manutenção de possíveis doadores, bem como na redução de recusas familiares para aumentar o número de doações efetivas. Objetivo MA. MA . (MA) Métodos retrospectiva quantitativa UTIs (UTIs 201 Utilizouse Utilizou ONT (ONT Espanha Brasil (ME) 2173 2 173 2.17 Medicina 31 3 Resultados avaliados 1 totalizando detalhada disso 311 31,1 desconhecidos geral diárias Conclusão efetivas (MA 20 (ME 217 2.1 31, 2.

ABSTRACT This study aimed to evaluate the addition of different concentrations of IGF-I and insulin to egg yolk-based extender to improve bovine semen cryopreservation. Two experiments were developed to evaluate the effects of the additives in two commercial extenders, Botubov® (Experiment 1) and Triladyl® (Experiment 2), both with the same design. Three ejaculates from four bulls (n = 12) were used. Each ejaculate was divided into seven equal fractions for dilution (60x106 spermatozoa/mL) in the following treatments: CON: extender only; IGF100: IGF-I 100ng/mL; IGF200: IGF-I 200ng/mL; INS150: insulin 150µUI/mL; INS200: insulin 200µUI/mL; ASS1: IGF-I 100ng/mL + insulin 150µUI/mL; ASS2: IGF-I 200ng/mL + insulin 200µUI/mL. Semen was cryopreserved by an automated system. Post-thawed sperm were evaluated regarding motility by CASA (Computer-assisted sperm analysis), and membranes by fluorescent probes (H342, PI, FITC-PSA and JC-1). For Botubov® extender, INS150 was more efficient in preserving total and progressive motility, VCL, BCF, plasma and mitochondrial membranes. A similar response was seen when insulin was added to the Triladyl® extender, INS150 was more efficient in preserving sperm motility, plasma membrane integrity and mitochondrial potential. Thus, the addition of insulin 150µUI/mL, regardless of the composition of the extender, contributes to better preserving bovine sperm from the cryopreservation effects. IGFI IGF I yolkbased yolk based extenders Botubov Experiment 1 Triladyl 2, 2 , 2) design n 12 used 60x106 x (60x10 spermatozoa/mL spermatozoamL spermatozoa mL treatments CON only IGF100 100ngmL ngmL 100ng ng IGF200 200ngmL 200ng INS 150µUI/mL 150µUImL µUImL 150µUI µUI INS200 200µUI/mL 200µUImL 200µUI ASS1 ASS ASS2 system Postthawed Post thawed Computerassisted Computer assisted analysis, analysis analysis) H342, H342 H (H342 PI FITCPSA FITC PSA JC1. JC1 JC . JC-1) INS15 VCL BCF potential Thus 60x10 (60x1 IGF10 IGF20 INS20 H34 (H34 JC-1 INS1 60x1 (60x IGF1 IGF2 INS2 H3 (H3 JC- 60x (H

RESUMO Este estudo teve o objetivo de avaliar a adição de diferentes concentrações de IGF-I e insulina a diluidores, à base de gema de ovo, para melhorar a criopreservação do sêmen bovino. Dois experimentos foram desenvolvidos para avaliar os efeitos dos aditivos em dois diluidores comerciais: Botubov® (Experimento 1) e Triladyl® (Experimento 2), ambos com o mesmo delineamento. Foram utilizados três ejaculados de quatro touros (n=12). Cada ejaculado foi dividido em sete frações para diluição (60x106espermatozoides/mL), nos seguintes tratamentos: CON: somente diluidor; IGF100: 100ng/mL de IGF-I; IGF200: 200ng/mL de IGF-I; INS150: 150µUI/mL de insulina; INS200: 200µUI/mL de insulina; ASS1: 100ng/mL de IGF-I + 150µUI/mL de insulina; ASS2: 200ng/mL de IGF-I + 200µUI/mL de insulina. O sêmen foi criopreservado por sistema automatizado. Após a criopreservação, o sêmen foi avaliado quanto à motilidade espermática por CASA e quanto às membranas espermáticas (plasmática, acrossomal e mitocondrial) por sondas fluorescentes (H342, PI, FITC-PSA e JC-1). Para o diluidor Botubov®, INS150 foi mais eficiente em preservar motilidades total e progressiva, VCL, BCF, integridade da membrana plasmática e potencial mitocondrial. Resposta semelhante foi observada quando a insulina foi adicionada ao diluidor Triladyl®, INS150 foi mais eficiente na preservação da motilidade, integridade das membranas e potencial mitocondrial quando comparado aos demais grupos. Assim, a adição de 150µUI/mL de insulina aos diluidores, independentemente da composição, contribui para melhor criopreservação dos espermatozoides bovinos. IGFI IGF I ovo bovino comerciais Botubov Experimento 1 Triladyl 2, 2 , 2) delineamento n=12. n12 n n=12 . 12 (n=12) 60x106espermatozoides/mL, 60x106espermatozoidesmL xespermatozoidesmL 60x106espermatozoides/mL 60x106espermatozoides mL x (60x106espermatozoides/mL) tratamentos CON IGF100 100ngmL ngmL 100ng ng IGF200 200ngmL 200ng INS 150µUImL µUImL 150µUI µUI INS200 200µUImL 200µUI ASS1 ASS ASS2 automatizado plasmática, (plasmática H342, H342 H (H342 PI FITCPSA FITC PSA JC1. JC1 JC JC-1) INS15 progressiva VCL BCF grupos Assim composição bovinos n1 n=1 (n=12 espermatozoidesmL xespermatozoides (60x106espermatozoides/mL IGF10 IGF20 INS20 H34 (H34 JC-1 INS1 n= (n=1 IGF1 IGF2 INS2 H3 (H3 JC- (n= (H (n

This article addresses the initial teacher training involving students from a Bachelor's Degree Program in Mathematics in the Supervised Internship I course. In this context, we disclose in this present article how the students collectively developed tasks, according to the perspective of Technological Pedagogical Content Knowledge (TPACK), through the programming of four tasks named: "Circumference," "Pentagon," "Hexagon," and "Equilateral Triangle," with the support of Educational Robotics. Due to the COVID-19 pandemic, during our research, the students utilized the Open Roberta platform with the purpose of constructing geometric figures. Through the utilization of Open Roberta, the tasks were collectively developed by the students to enhance their Robotics and Mathematics Knowledge. Throughout their experiences in the internship context, we observed that the students managed to integrate Robotic and Mathematical Knowledge in task development. Thus, through the execution of tasks supported by online robotics, this formative stage empowered the future educators to be well-equipped for a pedagogical approach aligned with the demands of 21st-century education.

Este artículo aborda la formación inicial de docentes con las estudiantes de un Curso de Licenciatura en Matemáticas en la asignatura de Práctica Supervisada I. En este contexto, desvelamos en este presente artículo cómo las estudiantes desarrollaron de manera colectiva algunas tareas, según la perspectiva del Conocimiento Tecnológico Pedagógico del Contenido (TPACK), a través de la programación de cuatro tareas denominadas: "Circunferencia", "Pentágono", "Hexágono" y "Triángulo Equilátero", con el apoyo de la Robótica Educativa. Debido a la pandemia causada por el COVID-19, durante nuestra investigación, las estudiantes utilizaron la plataforma Open Roberta con el propósito de construir figuras geométricas. Mediante el uso de Open Roberta, las tareas fueron desarrolladas de manera colectiva por las estudiantes para desarrollar su Conocimiento en Robótica y Matemáticas. Durante las experiencias en el contexto de la práctica, observamos que las estudiantes lograron integrar el Conocimiento en Robótica y Matemáticas en la elaboración de las tareas. De esta manera, a través de la ejecución de tareas respaldadas por la robótica en línea, esta etapa formativa capacitó a las futuras educadoras para estar preparadas para un enfoque pedagógico alineado con las demandas de la educación en el siglo XXI.

Este artigo aborda a formação inicial de professores com as estagiárias de um Curso de Licenciatura em Matemática na disciplina de Estágio Supervisionado I. Neste contexto, revelamos no presente artigo, como as estagiárias desenvolveram coletivamente alguma tarefas, segundo a perspectiva da Conhecimento Tecnológico Pedagógico do Conteúdo (TPACK), a partir da programação de quatro tarefas, denominadas como: Circunferência, Pentágono, Hexágono, Triângulo Equilátero com o apoio da Robótica Educacional. Devido a pandemia causada pelo COVID-19, durante a nossa pesquisa as estagiárias fizeram uso da plataforma do Open Roberta com o próposito de construir as figuras geométricas. Com o o uso do Open Roberta, as tarefas foram desenvolvidas coletivamente pelas estagiárias para que desenvolvessem o Conhecimento de Robótica e Matemática. Durante as vivências no contexto do estágio, observamos que estagiárias conseguiram integrar o Conhecimento de Robótica e Matemática na elaboração das tarefas. Desse modo, por intermédio da execução das tarefas com o suporte da robótica online, essa etapa formativa capacitou as futuras educadoras a estarem aptas a uma abordagem pedagógica alinhada com as demandas da educação no século XXI.

ABSTRACT Purpose: to compare the use of the Frequency Modulation (FM) System by children and adolescents in a public hearing health center in the state of São Paulo. Methods: the analysis of medical records based on eligibility criteria. Data were collected from 340 participants born between 1998 and 2011, fitted with FM System, and who attended the follow-up appointment after fitting the device. Data were analyzed descriptively and inferentially. Results: hard-of-hearing children and adolescents of both genders from all over Brazil, attending elementary, middle or high school in public or private schools, participated. The data showed that 115 children and 155 adolescents effectively used the device, especially at school. The main difficulty for children was the lack of support from teachers; for adolescents, it was the feeling of embarrassment. Conclusion: some difficulties, especially on children, in adhering to the use of FM Systems were identified. Hence, to ensure the FM System's effective use, the importance of providing guidance and awareness of its benefits to patients, and their family members and teachers, during the fitting appointment and follow-up consultations, is emphasized. Purpose (FM Paulo Methods criteria 34 199 2011 followup follow up device inferentially Results hardofhearing hard Brazil elementary schools participated 11 15 teachers embarrassment Conclusion difficulties identified Hence s patients consultations emphasized 3 19 201 1 20 2

RESUMO Objetivo: comparar o uso do Sistema de Frequência Modulada por crianças e adolescentes em um Serviço Público de Saúde Auditiva do estado de São Paulo. Métodos: análise de prontuários, balizada pelos critérios de elegibilidade. Foram coletados dados de 340 participantes adaptados com o Sistema de Frequência Modulada, nascidos entre 1998 e 2011 e que compareceram à consulta de retorno pós-adaptação do dispositivo. Os dados foram analisados de forma descritiva e inferencial. Resultados: participaram crianças e adolescentes de ambos os gêneros provenientes de todo Brasil, com deficiência auditiva, cursando o ensino fundamental I ou II e ensino médio na rede pública ou privada de ensino. Os dados revelaram que 115 crianças e 155 adolescentes faziam uso efetivo do dispositivo, especialmente na escola. As principais dificuldades relatadas foram a falta de apoio dos professores entre as crianças e o sentimento de vergonha entre os adolescentes. Conclusão: foram identificadas dificuldades na adesão ao uso do Sistema FM, sobretudo por parte das crianças. Diante disso, ressalta-se a importância da orientação e da conscientização dos benefícios do uso do Sistema FM aos pacientes, familiares e seus professores, tanto no momento da adaptação do dispositivo quanto nas consultas de acompanhamento, a fim de assegurar o seu uso efetivo. Objetivo Paulo Métodos prontuários elegibilidade 34 199 201 pósadaptação pós inferencial Resultados Brasil auditiva 11 15 escola Conclusão disso ressaltase ressalta se pacientes acompanhamento 3 19 20 1 2

Abstract Objectives: To evaluate the inconsistency between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases. Methods: A cross-sectional study including a sample of adolescents’ autopsies who died in a pediatric and adolescent tertiary hospital over 18 consecutive years. During this period, there were n = 2912 deaths, and n = 581/2912(20%) occurred in adolescents. Of these, n = 85/581(15%) underwent autopsies and were analyzed. Further results were divided into two groups: Goldman classes I or II (high disagreement between main clinical diagnosis of death and anatomopathological findings, n = 26) and Goldman classes III, IV or V (low or no disagreement between these two parameters, n = 59). Results: Median age at death (13.5 [10‒19] vs. 13 [10‒19] years, p = 0.495) and disease duration (22 [0‒164] vs. 20 [0‒200] months, p = 0.931), and frequencies for males (58% vs. 44%, p = 0.247) were similar between class I/II vs. class III/IV/V. The frequency of pneumonia (73% vs. 48%, p = 0.029), pulmonary abscess (12% vs. 0%, p = 0.026), as well as isolation of yeast (27% vs. 5%, p = 0.008), and virus (15% vs. 2%, p = 0.029) identified in the autopsy, were significantly higher in adolescents with Goldman class I/II compared to those with Goldman class III/IV/V. In contrast, cerebral edema was significantly lower in adolescents of the first group (4% vs. 25%, p = 0.018). Conclusion: This study showed that 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings. Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were more frequently identified at autopsy findings in the groups with major discrepancies. Objectives Methods crosssectional cross sectional 1 years period 291 deaths 581/291220% 581291220 581/2912 20% 581 581/2912(20% 85/58115% 8558115 85/581 15% 85 15 85/581(15% analyzed high 26 III low parameters 59. 59 . 59) Results 13.5 135 5 (13. 10‒19 1019 10 19 [10‒19 vs 0.495 0495 0 495 22 (2 0‒164 0164 164 [0‒164 2 0‒200 0200 200 [0‒200 months 0.931, 0931 0.931 , 931 0.931) 58% 58 (58 44 44% 0.247 0247 247 IIIIVV III/IV/V 73% 73 (73 48 48% 0.029, 0029 0.029 029 12% 12 (12 0% 0.026, 0026 0.026 026 0.026) 27% 27 (27 5% 0.008, 0008 0.008 008 0.008) (15 2% contrast 4% 4 (4 25 25% 0.018. 0018 0.018 018 0.018) Conclusion 30 Pneumonia 29 291220 581/291220 58129122 5812912 581/291 581/2912(20 58115 85/58115 855811 85581 85/58 8 85/581(15 13. (13 10‒1 101 [10‒1 0.49 049 49 ( 0‒16 016 16 [0‒16 0‒20 020 [0‒20 093 0.93 93 (5 0.24 024 24 7 (7 002 0.02 02 (1 000 0.00 00 001 0.01 01 3 29122 581/29122 581291 581/29 581/2912(2 5811 85/5811 8558 85/5 85/581(1 10‒ [10‒ 0.4 04 0‒1 [0‒1 0‒2 [0‒2 09 0.9 9 0.2 0.0 58129 581/2 581/2912( 855 85/ 85/581( [10 0. 0‒ [0‒ 5812 581/ [1 [0 [

Abstract The article aims to analyze the hyperconnection caused by teachers’ telework as a hypothesis of existential damage. Face-to-face teaching during the pandemic caused by the novel coronavirus has been replaced by emergency remote teaching (ERE) to inhibit contagion and thus contribute to containing the global health crisis and ensuring the right to education of children, young people and adults. In this way, teachers had to abruptly adapt to their work through virtual platforms and multiplatform applications for smartphones. This change, in the context of distress caused by the pandemic, can cause existential damage to the teacher due to the violation of the right to disconnection. From this perspective, the research aims to answer the following question: is this a demage of an individual or collective nature? Thus, we bring as a hypothesis: the abrupt change from face-to-face to remote teaching in the way it occurred configures existential damage to the category. For this purpose, this investigation has as general objective: to reflect, based on the abrupt change from face-to-face to remote teaching, how the hyperconnection caused by virtual work configures existential damage to teachers. For the development of this theoretical and exploratory study, a qualitative approach is used, combined with a bibliographic research procedure. As a theoretical framework, we take as a basis Byung-Chul Han’s concept of the performance society. From the elements that characterize the existential damage, we can infer that the remote work of teachers, in such conditions, can contribute to the violation of the right to disconnection and the consequent existential damage. Facetoface Face face ERE (ERE children adults smartphones perspective question nature Thus facetoface category purpose objective reflect study used procedure framework ByungChul Byung Chul Hans Han s society conditions

Resumo O artigo tem como objeto analisar a hiperconexão causada pelo teletrabalho dos professores como hipótese de dano existencial. O trabalho docente presencial no período da pandemia causada pelo novo coronavírus foi substituído pelo ensino remoto emergencial (ERE) para inibir o contágio e, assim, contribuir para conter a crise sanitária de abrangência mundial e garantir o direito à educação de crianças, jovens e adultos. Dessa forma os professores tiveram, abruptamente, de se adaptar ao trabalho por meio de plataformas virtuais e aplicativos multiplataforma para smartphones. Essa mudança, somada ao contexto de aflição causado pela pandemia, pode ocasionar um dano existencial no docente devido à violação do direito à desconexão. Sob essa perspectiva, a pesquisa parte do problema: seria esse um dano de natureza individual ou coletiva? Assim, trazemos como hipótese: a mudança abrupta do ensino presencial para o remoto da forma como ocorreu configura dano existencial à categoria. Para tal propósito, esta investigação tem por objetivo geral: refletir, com base na mudança abrupta do ensino presencial para o remoto, de que forma a hiperconexão causada pelo trabalho virtual configura dano existencial aos professores. Para o desenvolvimento deste estudo teórico e de cunho exploratório, utiliza-se uma abordagem qualitativa, aliada a um procedimento de pesquisa bibliográfica. Enquanto referencial teórico, tomamos como base o conceito de sociedade do desempenho de Byung-Chul Han. A partir dos elementos que caracterizam o dano existencial, podemos inferir que o trabalho remoto dos docentes, em tais condições, pode concorrer para violação ao direito à desconexão e ao consequente dano existencial. ERE (ERE assim crianças adultos tiveram abruptamente smartphones perspectiva problema coletiva Assim categoria propósito geral refletir exploratório utilizase utiliza qualitativa bibliográfica ByungChul Byung Chul Han docentes condições

ABSTRACT Introduction: We evaluated a set of factors associated with political orientation in Brazil considering the left, center, and right political spectrums, as well as a group of values based on Schwartz's Theory. This theory enables us to understand how personal values affect individual choices and behavior across different contexts, among which political orientation. Materials and method: Our source database was the sixth research wave of the World Values Survey, which included 1,146 respondents for Brazil in 2014. The confirmatory factor analysis allowed us to validate the Schwartz questionnaire and, subsequently, devise four indicators for the following values: conservation, openness to change, self-enhancement, and self-transcendence. In addition to these variables, we controlled the analysis of results using a multinomial model with a range of sociodemographic variables to assess the determinants of political self-positioning. Results: Conservation and openness to change were significant indicators to explain the difference between left and right. Self-transcendence, in turn, was a value more closely associated with citizens who identify as right-wing rather than center. Discussion: Political orientation in Brazil is heavily reliant on both values and group identities, i.e., sociodemographic characteristics. This is illustrated by the statistical significance of the following demographic variables: gender, age, perceived income level, and education level. Introduction center spectrums Schwartzs s Theory contexts method Survey 1146 1 146 1,14 2014 subsequently conservation selfenhancement, selfenhancement self enhancement, enhancement self-enhancement selftranscendence. selftranscendence transcendence. transcendence self-transcendence selfpositioning. selfpositioning positioning. positioning self-positioning Results Selftranscendence, Selftranscendence Self transcendence, Self-transcendence turn rightwing wing Discussion identities ie i e i.e. characteristics gender age level 114 14 1,1 201 i.e 11 1, 20 2

RESUMO Introdução: Avaliamos os fatores associados à orientação política no Brasil levando em consideração os espectros políticos de esquerda, centro e direita, bem como um conjunto de valores baseados na Teoria de Schwartz. Essa teoria permite entender como os valores pessoais afetam as escolhas e comportamentos dos indivíduos em diferentes contextos, inclusive em relação à orientação política. Materiais de métodos: Utilizamos a base de dados da sexta onda de pesquisa da World Value Survey, com 1.146 entrevistados para o Brasil no ano de 2014. A análise fatorial confirmatória permitiu validar o questionário de Schwartz e, com isso, elaborar quatro indicadores para os seguintes valores: conservadorismo, abertura à mudança, autopromoção e autotranscendência. Além dessas variáveis, controlamos a análise dos resultados através de um modelo multinomial por um conjunto de variáveis sociodemográficas para avaliar os determinantes do autoposicionamento político. Resultados: Os indicadores de conservadorismo e a abertura à mudança foram significativos para explicar a diferença entre esquerda e direita. A autotranscendência, por sua vez, é um valor que está associado mais aos cidadãos que se identificaram como de direita do que de centro. Discussão: Além da importância dos valores para explicar a orientação política no Brasil, as identidades de grupo, isto é, as características sociodemográficas, também são relevantes. Isto é ilustrado pela significância estatística dos parâmetros das seguintes variáveis demográficas: gênero, idade, percepção do nível de renda e nível de escolaridade. Introdução contextos métodos Survey 1146 1 146 1.14 2014 isso autotranscendência político Resultados vez Discussão grupo relevantes demográficas gênero idade escolaridade 114 14 1.1 201 11 1. 20 2

ABSTRACT The study aimed to assess the effect of progressive neutralization on the antimicrobial properties against bacteria and yeasts of wood vinegar obtained from the pyrolysis of Eucalyptus urograndis (clone I144) wood. Wood samples were carbonized at a heating rate of 0.9 °C min-1 until a final temperature of 450 °C, totalizing 8 hours of carbonization. The raw pyrolysis liquids were left to settle, and the aqueous fraction was separated. Then, the aqueous fraction (raw wood vinegar - WV) was purified to yield the WV. WV samples were collected and neutralized from pH 2.5 until 7.5 (2.5, 3.0, 3.5, 4.0, 4.5, 5.0, 5.5, 6.0, 6.5, 7.0, and 7.5, by adding NaOH solution. Through the broth microdilution method, the antimicrobial effect of the neutralized samples at each pH was assessed on Pseudomonas aeruginosa (ATCC 27853), Salmonella enteritidis (ATCC 13076), Staphylococcus aureus (ATCC 25923), Streptococcus agalactiae (CEPA CLINICA), and Candida albicans (ATCC 10231). The minimum inhibitory concentration (MIC) and minimum bactericidal (and fungicidal) concentrations were determined through in vitro technics. Results were subjected to logarithmic regression analysis, and statistical models were fitted for each microorganism in the assessed pH range; as pH increased, a progressive decrease in the CIM increased, demanding higher concentrations of WV to inhibit microbial growth. The more resistant strains were S. aureus and S. agalactiae, which required an increase in WV concentration from a minimum of 6.25% at pH 2.5 to reaching 50% at pH 6.0. When at pH 7.0, both strains were not inhibited even at 50% (the highest concentration evaluated in the study). In contrast, C. albicans proved to be the most sensitive strain, starting from 3.12% EP at pH 2.5 and requiring only 25% for inhibition at pH 7.0. The behavior of P. aeruginosa and S. enteritidis followed the pattern of C. albicans, differing only at pH 7.0, where they required 50% of EP. As observed, even at neutral and slightly alkaline pH, the inhibitory activity of EP on microbial growth was maintained to some extent. Nevertheless, even when neutral and slightly alkaline pH values are reached, the inhibitory activity remains at a certain level. Higher pH values of the WV were associated with lower antimicrobial activity. However, its activity remained even at neutral and slightly alkaline pH values. clone I144 I 09 0 9 0. C min1 min 1 min- 45 carbonization settle separated Then 25 2 5 2. 75 7 7. 2.5, (2.5 30 3 3.0 35 3.5 40 4 4.0 4.5 50 5.0 55 5.5 60 6 6.0 65 6.5 70 7.0 solution method ATCC 27853, 27853 , 27853) 13076, 13076 13076) 25923, 25923 25923) CEPA CLINICA, CLINICA CLINICA) 10231. 10231 . 10231) MIC (MIC fungicidal technics analysis range increased S 625 6.25 study. study) contrast strain 312 12 3.12 P observed extent Nevertheless reached level However I14 (2. 3. 4. 5. 6. 2785 1307 2592 1023 62 6.2 31 3.1 I1 (2 278 130 259 102 ( 27 13 10

RESUMO O presente trabalho teve como objetivo avaliar o efeito da neutralização progressiva na atividade antimicrobiana do extrato pirolenhoso (EP) da madeira do híbrido Eucalyptus urophylla x Eucalyptus grandis (clone I144). Amostras de madeira foram carbonizadas a uma taxa de aquecimento de 0.9 °C min-1 até a temperatura final de 450 °C, perfazendo 8 horas de carbonização. Os líquidos brutos da carbonização foram deixados em repouso e a fração aquosa foi separada. A fração aquosa correspondente ao EP bruto foi destilada obtendo o EP purificado. Alíquotas de EP purificado foram progressivamente neutralizadas do pH 2.5 até 7.5, respectivamente, 2,5, 3,0, 3,5, 4,0, 4,5, 5,0, 5,5, 6,0, 6,5, 7,0, e 7,5, por meio da adição de NaOH. Com o método da micro-diluição em caldo, o efeito antimicrobiano das amostras neutralizadas em cada pH foi avaliado contra Pseudomonas aeruginosa (ATCC 27853), Salmonella enteritidis (ATCC 13076), Staphylococcus aureus (ATCC 25923), Streptococcus agalactiae (CEPA CLINICA) e Candida albicans (ATCC 10231). As concentrações inibitórias mínimas e as concentrações bactericida e fungicida mínimas foram determinadas por técnicas in vitro. Os resultados foram analisados por regressão logarítmica e modelos estatísticos foram ajustados para cada microrganismo em cada pH. Na determinação da CIM, foi detectada uma perda progressiva da atividade antimicrobiana do EP com a neutralização, exigindo, conforme o pH caminhava para 7.0, concentrações mais elevadas de EP para resultar em inibição. As cepas que demonstraram maior resistência foram S. aureus e S. agalactiae. Esses microrganismos partiram da exigência de concentrações de 6.25% de EP, em pH inicial (2.5), e chegaram a requerer 50% em pH 6.0. Quando em pH 7.0, ambas as cepas não foram inibidas nem a 50% (maior concentração avaliada no estudo). Em contrapartida, C. albicans se mostrou a cepa mais sensível, partindo de 3.12% de EP, em pH de 2.5, e exigindo apenas 25% para inibição em pH 7.0. O comportamento de P. aeruginosa e S. enteritidis acompanhou o padrão da C. albicans, diferenciando-se apenas em pH 7.0, onde exigiram 50% de EP. Como observado, mesmo em pH neutro e ligeiramente alcalino, a atividade inibitória do EP ao crescimento microbiano se manteve em certa extensão. (EP clone I144. I144 I . I144) 09 0 9 0. C min1 min 1 min- 45 separada 25 2 5 2. 75 7 7.5 respectivamente 2,5 30 3 3,0 35 3,5 40 4 4,0 4,5 50 5,0 55 5,5 60 6 6,0 65 6,5 70 7,0 7,5 NaOH microdiluição micro diluição caldo ATCC 27853, 27853 , 27853) 13076, 13076 13076) 25923, 25923 25923) CEPA CLINICA 10231. 10231 10231) vitro CIM 7.0 S 625 6.25 (2.5) 6.0 estudo. estudo estudo) contrapartida sensível 312 12 3.12 P diferenciandose diferenciando observado alcalino extensão I14 7. 2, 3, 4, 5, 6, 7, 2785 1307 2592 1023 62 6.2 (2.5 6. 31 3.1 I1 278 130 259 102 (2. 3. 27 13 10 (2 (

Resumen La financiación pública ha ido cobrando protagonismo en los estudios de políticas públicas deportivas, ya que permite tener una visión más transparente de dónde y cómo se asignan los recursos públicos al sector. Este artículo tiene como objetivo analizar del financiamiento de las políticas públicas deportivas en el Distrito Federal (DF), a partir de una propuesta matricial y metodológica que permite recolectar y sistematizar datos referentes a la identificación de fuentes, magnitud y dirección del gasto público presupuestario en deportes, de 2009 a 2019. La investigación señaló: (i) la falta de una legislación efectiva para garantizar los recursos deportivos; (ii) la centralidad de la ejecución presupuestaria por parte de la Secretaría de Deportes del Distrito Federal; (iii) altos gastos con la construcción del Estadio Nacional de Brasilia; y (iv) la priorización del gasto deportivo en los programas ofrecidos, con prioridad en los Centros Olímpicos y Paralímpicos, gestión externalizada, además de capilaridad y alcance reducidos. sector DF, DF , (DF) fuentes deportes 200 2019 señaló i (i deportivos ii (ii iii (iii Brasilia iv (iv ofrecidos Paralímpicos externalizada reducidos (DF 20 201 2

Abstract Public funding has been gaining prominence in studies of sports public policies as it provides a more transparent view of where and how public resources are allocated to the sector. This article aims to analyze the financing of public policies for sports in the Federal District (FD), based on a matrix and methodological proposal that allows the survey and systematization of data referring to the identification of sources, magnitude, and direction of public budget expenditure on sports from 2009 to 2019. The research points out: (i) the lack of effective legislation to guarantee sports resources; (ii) the centrality of budget execution by the Secretariat of Sports of the Federal District; (iii) high expenses with the construction of the Brasília National Stadium; and (iv) the prioritization of sports spending in the offered programs, with priority given to the Olympic and Paralympic Centers, outsourced management, in addition to reduced capillarity and scope. sector FD, FD , (FD) sources magnitude 200 2019 out i (i ii (ii iii (iii Stadium iv (iv programs Centers management scope (FD 20 201 2

Resumo O financiamento público vem ganhando destaque nos estudos das políticas públicas esportivas, pois permite visualizar de forma mais transparente onde e como são alocados os recursos públicos para o setor. Este artigo tem como objetivo analisar o financiamento das políticas públicas de esporte do Distrito Federal (DF), a partir de matriz e proposta metodológica que possibilitam o levantamento e sistematização de dados referentes à identificação das fontes, magnitude e direcionamento dos gastos públicos orçamentários com o esporte de 2009 a 2019. A pesquisa apontou: (i) falta de legislação efetiva para garantia dos recursos esportivos; (ii) centralidade da execução do orçamento pela Secretaria de Esporte do Distrito Federal; (iii) elevado gasto com a construção do Estádio Nacional de Brasília; e, (iv) hierarquização dos gastos esportivos nos programas oferecidos, com priorização aos Centros Olímpicos e Paralímpicos, ação com gestão terceirizada, além de capilaridade e abrangência reduzidas. esportivas setor DF, DF , (DF) fontes 200 2019 apontou i (i ii (ii iii (iii Brasília iv (iv oferecidos Paralímpicos terceirizada reduzidas (DF 20 201 2