RESUMO Este estudo avaliou a eficácia da terapia com luz de baixo nível (LLLT) no tratamento de três pacientes com paralisia de Bell (PB) e revisou a literatura relevante. O primeiro caso envolveu uma mulher de 52 anos com PB grau V, que, após receber tratamento farmacológico e realizar sete sessões de LLLT (780 nm; 70 mW; E = 9 J), melhorou para grau II em 21 dias. O segundo caso foi de um homem de 37 anos que, após não ter apresentado resposta ao tratamento anteriormente, recebeu 24 sessões de LLLT e progrediu de grau V para grau II ao longo de 4 meses. O terceiro caso envolveu um homem de 40 anos que, após medicação e oito sessões de LLLT, melhorou de grau V para grau I em 1,5 meses. No geral, a LLLT demonstrou melhorar significativamente a função facial, a estética e o bem-estar geral desses pacientes em um período relativamente curto.

ABSTRACT This study evaluated the efficacy of low-level light therapy (LLLT) in the treatment of three patients with Bell's palsy (BP) and reviewed relevant literature. The first case involved a 52year-old woman with grade V BP, who, after receiving pharmacological treatment and undergoing seven sessions of LLLT (780 nm; 70 mW; E = 9 J), improved to grade II within 21 days. The second case was a 37-year-old man who, having previously shown no response to treatment, received 24 sessions of LLLT and progressed from grade V to grade II over the course of 4 months. The third case involved a 40-year-old man who, following medication and eight sessions of LLLT, improved from grade V to grade I in 1.5 months. Overall, LLLT was found to significantly enhance facial function, aesthetics, and overall well-being in these patients within a relatively short period.

RESUMEN Este estudio evaluó la eficacia de la terapia por luz de baja intensidad (LLLT, por sus siglas en inglés) en el tratamiento de tres pacientes con parálisis de Bell (BP) y revisó la literatura relacionada. Un caso involucró a una mujer de 52 años con BP grado V, quien, después de recibir terapia con medicamentos y siete sesiones de LLLT (780 nm; 70 mW; E = 9 J), mejoró al grado II en 21 días. Otro caso, un hombre de 37 años, previamente no receptivo a tratamientos, se sometió a 24 sesiones de LLLT, pasando del grado V al II en 4 meses. Finalmente, un hombre de 40 años tratado con medicamentos y 8 sesiones de LLLT mejoró del grado V al I en 1,5 meses. En esencia, la LLLT mejoró significativamente las funciones faciales, la estética y el bienestar general de los pacientes en un corto período de tiempo.

ABSTRACT Purpose: To compare biochemical recurrence, sexual potency and urinary continence outcomes of ablative therapy and radical treatment (radical prostatectomy or radiotherapy with androgen deprivation therapy). Material and methods: A systematic review and meta-analysis followed the PRISMA guidelines were performed. We searched MEDLINE/PubMed. Biochemical recurrence at three and five years; incontinence rate (patients who used one pad or more) and erectile dysfunction rate at 12 and 36 months (patients who did not have sufficient erection to achieve sexual intercourse) were evaluated. The Mantel-Haenszel method was applied to estimate the pooled risk difference (RD) in the individual studies for categorical variables. All results were presented as 95% confidence intervals (95%CI). Random effects models were used regardless of the level of heterogeneity (I²). (PROSPERO CRD42022296998). Results: Eight studies comprising 2,677 men with prostate cancer were included. There was no difference in biochemical recurrence between ablative and radical treatments. We observed the same biochemical recurrence between ablative therapy and radical treatment within five years (19.3% vs. 16.8%, respectively; RD 0.07; 95%CI=-0.05, 0.19; I2=68.2%; P=0.08) and continence rate at 12 months (9.2% vs. 31.8%, respectively; RD −0.13; 95%CI, −0.27, 0.01; I2=89%; P=0.32). When focal treatment was analyzed alone, two studies with 582 patients found higher erectile function at 12 months in the ablative therapy group than in the radical treatment (88.9% vs. 30.8%, respectively; RD −0.45; 95%CI −0.84, −0.05; I2=93%; P=0.03). Conclusion: Biochemical recurrence and urinary continence outcomes of ablative therapy and radical treatment were similar. Ablative therapy appears to have a high rate of sexual potency. Purpose therapy. . therapy) methods metaanalysis meta analysis performed MEDLINEPubMed MEDLINE PubMed MEDLINE/PubMed more 1 3 intercourse evaluated MantelHaenszel Mantel Haenszel (RD variables 95 95%CI. 95CI CI (95%CI) I². I² I (I²) PROSPERO CRD42022296998. CRD42022296998 CRD CRD42022296998) Results 2677 2 677 2,67 included treatments 19.3% 193 19 (19.3 vs 168 16 8 16.8% respectively 0.07 007 0 07 95%CI=0.05, 95CI005 95%CI= 0.05, 05 95%CI=-0.05 0.19 019 I2=68.2% I2682 I2 68 P=0.08 P008 P 08 9.2% 92 9 (9.2 318 31 31.8% −0.13 013 13 027 27 −0.27 0.01 001 01 I2=89% I289 89 P=0.32. P032 P=0.32 32 P=0.32) alone 58 88.9% 889 88 (88.9 308 30 30.8% −0.45 045 45 084 84 −0.84 −0.05 005 I2=93% I293 93 P=0.03. P003 P=0.03 03 P=0.03) Conclusion similar (95%CI (I² CRD4202229699 267 67 2,6 19.3 (19. 16.8 0.0 00 95%CI=0.05 95CI00 0.05 95%CI=-0.0 0.1 I2=68.2 I268 6 P=0.0 P00 9.2 (9. 31.8 −0.1 02 −0.2 I2=89 I28 P03 P=0.3 5 88.9 (88. 30.8 −0.4 04 4 −0.8 −0.0 I2=93 I29 (I CRD420222969 26 2, 19. (19 16. 0. 95%CI=0.0 95CI0 95%CI=-0. I2=68. I26 P=0. P0 9. (9 31. −0. I2=8 88. (88 30. I2=9 CRD42022296 (1 95%CI=0. 95%CI=-0 I2=68 P=0 ( −0 I2= (8 CRD4202229 95%CI=0 95%CI=- I2=6 P= − CRD420222 CRD42022 CRD4202 CRD420 CRD42 CRD4

Resumo Ana, empregada doméstica, foi dispensada grávida, por justa causa, após ter usado os cosméticos da patroa. A partir desse caso judicial real, o artigo discute as desobediências (i)legítimas praticadas no trabalho doméstico como potenciais formas de resistência à desigualdade e à exploração. Para tanto, o artigo se constituirá na recomposição etnográfica de um processo judicial, buscando, por meio da prosa jurídico-processual, compreender a posição dos atores envolvidos e sua produção discursiva diante do direito. Patrão e patroa, família, trabalhadora, advogados, juízes, desembargadores, ministros. Tudo isso a partir de um trânsito teórico entre autoras que discutem o caráter político da vida doméstica, do trabalho doméstico e da reprodução social; as possibilidades de dano à propriedade por motivação política e o processo de resistência de trabalhadoras domésticas. Concluímos que as insurgências, ainda que silenciosas e individuais, praticadas pelas trabalhadoras domésticas que causaram dano à propriedade dos empregadores são práticas legítimas de autodefesa e significam um momento de pausa na expropriação e na alienação do trabalho. Ana doméstica grávida causa patroa real ilegítimas i exploração tanto buscando jurídicoprocessual, jurídicoprocessual jurídico processual, processual jurídico-processual direito família trabalhadora advogados juízes desembargadores ministros social insurgências individuais

Abstract Ana, a domestic worker, pregnant, was dismissed by justified termination after using her employer's cosmetics. Based on this real court case, the article discusses the (il)legitimate disobedience practiced in domestic work, as a potential form of resistance to inequality and exploitation. To this aim, the article will consist of an ethnographic reconstruction of a lawsuit, seeking, through legal-procedural prose, to understand the position of the actors involved and their discursive production in the face of the law. Boss and mistress, family, worker, lawyers, judges, justices. All of this is based on a theoretical transit between authors who discuss the political character of domestic life, domestic work and social reproduction; the possibilities of politically motivated property damage and the resistance process of domestic workers. The conclusion is that the insurgencies, albeit silent and individual, practiced by domestic workers who have caused damage to employers' property are legitimate practices of self-defense and signify a moment of pause in the expropriation and alienation of labor. Ana worker pregnant employers employer s cosmetics case illegitimate il exploitation aim lawsuit seeking legalprocedural legal procedural prose law mistress family lawyers judges justices life reproduction insurgencies individual selfdefense self defense labor

ABSTRACT. Although acerola (Malpighia emarginata DC.) is a tropical fruit of high interest due to its high ascorbic acid content and attractive sensory attributes, fruit production is characterized by high genetic variability. Additionally, the use of new biometric tools for acerola breeding is scarce. This study aimed to estimate genetic parameters and the coefficient of repeatability, as well as determine the optimal number of fruits for quality trait analyses in different acerola genotypes, using different approaches. Twenty-three (Experiment I) and thirty-five (Experiment II) genotypes were evaluated in a randomized block design with four replicates and three plants per plot. Twenty fruits per plant were harvested and evaluated for the following quality traits: diameter, mass, skin color (lightness, chroma and hue), firmness, soluble solids (SS), titratable acidity (TA), SS/TA ratio, and ascorbic acid content. The genetic parameters and the coefficient of repeatability were estimated for each experiment using classical and Bayesian methods. Both approaches achieved similar results on estimating variance components, genetic parameters and the coefficient of repeatability. Genetic parameters showed favorable conditions for acerola selection. The coefficient of repeatability was high for all acerola quality traits. A total of 17 fruits are required for the effective selection of acerola genotypes with an accuracy of 95%. ABSTRACT Malpighia DC. DC attributes variability Additionally scarce Twentythree Experiment I thirtyfive thirty five II plot traits diameter mass lightness, lightness (lightness hue, hue , hue) firmness SS, SS (SS) TA, TA (TA) SSTA ratio methods components 1 95 95% (SS (TA 9

Abstract Pulmonary arterial hypertension (PAH) is characterized by right ventricular failure and diminished cardiac output, potentially leading to renal and bone impairments. In contrast, resistance exercise training (RT) offers cardiovascular and bone health benefits. This study aimed to assess the impacts of stable PAH induced by monocrotaline (MCT) and RT on renal morphometry, as well as bone morphometry and biomechanical properties in male Wistar rats. Four experimental groups, untrained control (UC, n=7), trained control (TC, n=7), untrained hypertensive (UH, n=7), trained hypertensive (TH, n=7), were defined. After the first MCT or saline injection (20 mg/kg), trained rats were submitted to a RT program (i.e., Ladder climbing), 5 times/week. Seven days later the rats received the second MCT or saline dose. After euthanasia, renal and femoral histomorphometry and femoral biomechanical properties were assessed. PAH reduced renal glomerular area and volume, which was prevented by the RT. While PAH did not harm the femoral morphometry, structural and mechanical properties, RT improved the femoral parameters (e.g., length, percentage of trabeculae and bone marrow, ultimte and yield loads). Experimental stable PAH promotes renal but not bone damages, whereas RT prevents renal deteriorations and improves the femoral morphological and biomechanical properties. (PAH output impairments contrast (RT benefits (MCT groups UC, UC (UC n=7, n7 n n=7 , 7 n=7) TC, TC (TC UH, UH (UH TH, TH (TH defined 20 (2 mg/kg, mgkg mg/kg mg kg mg/kg) i.e., ie i e (i.e. climbing, climbing climbing) timesweek times week times/week dose euthanasia assessed volume e.g., eg g (e.g. length marrow loads. loads . loads) damages n= 2 ( i.e. (i.e e.g. (e.g i.e e.g

RESUMO Objetivo: Este estudo pretende avaliar a aspirina como profilaxia química (200 mg) na artroplastia total do quadril. Métodos: estudo comparando dois grupos com diferentes doses de aspirina e utilizando a ultrassonografia (USG) para rastreamento da trombose venosa profunda baixa. O grupo 1, 650 mg ao dia de aspirina (controle) e o grupo 2, 200 mg de aspirina ao dia na mesma posologia (intervenção) e associados ao uso de meias elásticas de compressão e deambulação precoce. Resultados: quatorze pacientes foram alocados no grupo A (200 mg) e 16 no grupo B (650 mg). No grupo A foram detectados 3 casos com trombos abaixo da veia poplítea ao USG sendo 21,4%. Já no grupo B, 5 casos foram identificados após o primeiro exame (31,2%). Todos assintomáticos e sem sinais de sangramento ativo ou queda da hematimetria no momento da detecção dos trombos. Conclusão: os dados sugerem não haver diferença na incidência de trombo em ambos os grupos, não sendo a profilaxia com a aspirina dose-dependente. Os níveis hematimétricos retornaram aos níveis iniciais o que sugere não ter havido sangramento crônico ou agudo relacionado ao uso. Nível de Evidência I; Estudo Clínico Randomizado Longitudinal Comparativo. Objetivo (20 quadril Métodos (USG baixa 1 65 controle (controle 2 20 intervenção (intervenção precoce Resultados (65 mg. . 214 21 4 21,4% 31,2%. 312 31,2% 31 (31,2%) Conclusão dosedependente. dosedependente dose dependente. dependente dose-dependente I Comparativo (2 6 (6 21,4 31,2 (31,2% ( 21, 31, (31,2 (31, (31 (3

ABSTRACT Objective: This study aims to evaluate aspirin as a chemical prophylaxis (200 mg) in total hip arthroplasty. Methods: the study compared two groups and used ultrasonography (USG) to screen for low-deep venous thrombosis. Group 1 received 600 mg (control), and Group 2 received 200 mg of (intervention), associated with the use of elastic compression stockings and early walking Results: fourteen patients were allocated to Group A (200mg), and 16 to Group B (600mg); in group A (200mg), 3 cases with thrombus below the popliteal vein were detected at the first USG examination. All of them are in the left lower limb (21.4%). In group B (600 mg), 5 cases were identified after the first exam (31.2%). All cases were asymptomatic and followed the protocol with prophylaxis only with Aspirin. Conclusion: In the statistical data, there were no differences in the presence of thrombus between the 200- and 600 mg groups, which is credited to using low-dose aspirin in low doses (200mg). Hematimetric levels returned to baseline levels and suggested there was no chronic or acute bleeding related to the use of aspirin. The manuscript was prepared according to the CONSORT guideline 2010. Level of Evidence I; Longitudinal Randomized Comparative Clinical Study. Objective (20 arthroplasty Methods (USG lowdeep deep thrombosis 60 control, control , (control) 20 intervention, intervention (intervention) Results 200mg, 200mg (200mg) 600mg (600mg) examination 21.4%. 214 21.4% . 21 4 (21.4%) (60 mg, 31.2%. 312 31.2% 31 (31.2%) Aspirin Conclusion data lowdose dose 200mg. 2010 I Study (2 6 (control (intervention (200mg (600mg 21.4 (21.4% (6 31.2 (31.2% 201 ( 21. (21.4 31. (31.2 (21. (31. (21 (31 (3

Abstract Coffee leaf rust, caused by Hemileia vastatrix, is the most important disease affecting Coffea arabica. The use of molecular markers through marker-assisted selection (MAS) is an effective approach to develop cultivars with multiple and durable resistance, which is economically and environmentally beneficial for this disease control. In this work, a new molecular marker based on allele-specific polymerase chain reaction (AS-PCR) associated with the quantitative trait locus (QTL) of the linkage group 5 (LG5), which confers resistance to races I, II and pathotype 001 of H. vastatrix, was developed. The CaRHv10-AS marker was validated in a segregating genetic mapping population of 247 F2 genotypes and demonstrated selection efficiency greater than 97% for genotypes with resistance to three races. Thus, this work provides a fast, robust, and affordable molecular marker for use in MAS, facilitating the development of coffee plants with multiple resistance and ensuring sustainable coffee production. rust vastatrix arabica markerassisted assisted MAS (MAS control allelespecific allele specific ASPCR AS PCR (AS-PCR QTL (QTL LG5, LG5 LG , (LG5) I 00 H developed CaRHv10AS CaRHvAS CaRHv10 CaRHv 24 F 97 Thus fast robust production (LG5 0 CaRHv1 2 9 (LG

RESUMO Objetivo: Avaliar a capacidade de identificar possíveis doadores de órgãos em um hospital universitário no estado do Maranhão (MA). Métodos: O estudo é uma coorte retrospectiva, quantitativa, baseada na análise documental de prontuários de pacientes falecidos nas unidades de terapia intensiva (UTIs) de adultos de um hospital universitário no MA, no período de 2018 a 2019. Utilizou-se o Instrumento de Triagem I da Organización Nacional de Trasplantes (ONT) da Espanha, fundamentado por Avedis Donabedian e validado no Brasil, para identificar possíveis doadores com indícios clínicos de morte encefálica (ME). A análise envolveu a revisão dos prontuários e a aplicação de critérios de diagnóstico de ME, conforme a Resolução nº 2.173 de 2017 do Conselho Federal de Medicina. Foram analisados 312 prontuários, resultando em 38 com sinais de ME, classificados como escapes por falhas na identificação e manutenção dos doadores. Resultados: Dos 312 prontuários avaliados, 21 de 2018 e 17 de 2019 (totalizando 38) apresentaram indícios clínicos de ME e foram selecionados para auditoria detalhada. Além disso, foi identificado que 31,1% dos escapes ou perdas de possíveis doadores ocorreram devido a óbitos não identificados como ME, gerando indicadores antes desconhecidos. A ferramenta revelou que pacientes submetidos a tratamento cirúrgico para tumores encefálicos e doenças cerebrovasculares têm maior probabilidade de evoluir para ME. Esses pacientes, geralmente internados na UTI geral, devem receber atenção especial nas avaliações diárias, pois têm alto potencial para se tornarem doadores de órgãos. Conclusão: A auditoria evidenciou a necessidade de melhorias na identificação e manutenção de possíveis doadores, bem como na redução de recusas familiares para aumentar o número de doações efetivas. Objetivo MA. MA . (MA) Métodos retrospectiva quantitativa UTIs (UTIs 201 Utilizouse Utilizou ONT (ONT Espanha Brasil (ME) 2173 2 173 2.17 Medicina 31 3 Resultados avaliados 1 totalizando detalhada disso 311 31,1 desconhecidos geral diárias Conclusão efetivas (MA 20 (ME 217 2.1 31, 2.

ABSTRACT Objective: To assess the capacity to identify potential organ donors in a university hospital in Maranhão (MA). Methods: The study is a retrospective, quantitative cohort based on the documentary analysis of medical records of deceased patients in the adult intensive care units (ICUs) of a university hospital in MA from 2018 to 2019. Screening Instrument I from the Organización Nacional de Trasplantes (ONT) of Spain, based on Avedis Donabedian and validated in Brazil, was used to identify potential donors with clinical signs of brain death (BD). The analysis involved reviewing medical records and applying BD diagnostic criteria, according to Conselho Federal de Medicina Resolution nº 2,173 of 2017. A total of 312 records were analyzed, resulting in 38 with signs of BD, classified as escapes due to identification and maintenance failures of potential donors. Results: Of the 312 evaluated records, 21 from 2018 and 17 from 2019 (totaling 38) presented clinical signs of BD and were selected for detailed auditing.Additionally, it was identified that 31.1% of the escapes or losses of potential donors resulted from deaths not identified as BD, generating previously unknown indicators. The tool revealed that patients undergoing surgical treatment for brain tumors and cerebrovascular diseases have a higher likelihood of evolving to BD. These patients, usually admitted to the general ICU, should receive special attention in daily assessments due to their high potential to become organ donors. Conclusion: The audit highlighted the need for improvements in the identification and maintenance of potential donors, as well as in reducing family refusals, to increase the number of effective donations. Objective MA. . (MA) Methods retrospective ICUs (ICUs 201 ONT (ONT Spain Brazil (BD) criteria 2173 2 173 2,17 2017 31 analyzed 3 Results 1 totaling auditingAdditionally auditing Additionally auditing.Additionally 311 31.1 indicators ICU Conclusion refusals donations (MA 20 (BD 217 2,1 31. 2,

ABSTRACT Objective Weight regain is a common outcome of weight loss interventions. Mental health-related comorbidities, among other factors, can mediate weight regain regardless of the implemented treatment modality. This study explores whether postoperative psychopathological comorbidities are associated with weight regain after bariatric surgery. Subjects and methods This cross-sectional study recruited 90 outpatients who underwent Roux-en-Y gastric bypass surgery. Anthropometric measurements were collected retrospectively from medical charts. The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorder-IV (DSM-IV) Axis I Disorders (SCID-I) was applied to evaluate psychiatry diagnoses. Validated self-report instruments were used to assess depression, anxiety, alcohol use, impulsivity, binge eating, and body image dissatisfaction. Weight regain was defined as a ≥20% increase from the maximum weight lost. Level of evidence: Level III, cross-sectional study based on a well-designed study. Results Overall, 55.6% of participants experienced weight regain. Notably, mental disorders such as current binge-eating disorder and lifetime diagnoses including bulimia nervosa, alcohol abuse/dependence, and obsessive-compulsive disorder were significantly associated with weight regain. However, controlled analysis found that, for mental disorders, only current binge-eating disorder (odds ratio [OR] 6.3, 95% confidence interval [CI] 1.26-31.06, p = 0.024) remained associated with weight regain. Eating-related psychopathologies also associated with weight regain included binge eating (d = 0.55; p = 0.013), eating disinhibition (d = 0.76; p = 0.001), higher hunger levels (d = 0.39; p = 0.004), and non-planning trait impulsivity (d = 0.69; p = 0.0001). Conclusion Postoperative presence of psychopathological comorbidities, such as eating psychopathology and trait impulsivity, were associated with weight regain after bariatric surgery. These findings highlight the importance of addressing mental health in individuals experiencing postsurgical weight regain. interventions healthrelated related factors modality surgery crosssectional cross sectional 9 RouxenY Roux en Y charts DisorderIV Disorder IV DSMIV DSM (DSM-IV SCIDI SCID (SCID-I selfreport self report depression anxiety use dissatisfaction 20 ≥20 lost evidence III welldesigned well designed Overall 556 55 6 55.6 Notably bingeeating nervosa abusedependence abuse dependence abuse/dependence obsessivecompulsive obsessive compulsive However that odds OR [OR 63 3 6.3 95 CI [CI 1.2631.06, 1263106 1.26 31.06, 1 26 31 06 1.26-31.06 0.024 0024 0 024 Eatingrelated Eating d 0.55 055 0.013, 0013 0.013 , 013 0.013) 0.76 076 76 0.001, 0001 0.001 001 0.001) 0.39 039 39 0.004, 0004 0.004 004 0.004) nonplanning non planning 0.69 069 69 0.0001. 00001 0.0001 . 0.0001) 2 ≥2 5 55. 6. 2631 1.2631.06 126310 126 1.2 3106 31.06 1.26-31.0 0.02 002 02 0.5 05 0.01 01 0.7 07 7 000 0.00 00 0.3 03 0.6 0000 0.000 ≥ 263 1.2631.0 12631 12 1. 310 31.0 1.26-31. 0.0 0. 1.2631. 1263 31. 1.26-31 1.2631 1.26-3 1.263 1.26-

Abstract Objective Despite some knowledge gaps in scientific evidence, MgCl2 is largely used for pain relief in musculoskeletal diseases. Mg salts were shown to provide analgesia postoperatively in orthopedic surgery and low Mg levels were linked to arthritis development and severity. We determined the anti-inflammatory activity of MgCl2 in an acute arthritis model. Methods Mice received 0.1 mg/25μL Zymosan (Zy) or saline into the knees. Joint pain was evaluated using von Frey test; cell influx, and interleukin (IL)-1 level were assessed in joint lavage at 6 h. Synovia were excised for histopathology and analysis of immunoexpression of nuclear factor kappa B (NFκB) and tumor necrosis factor (TNF)-α. Groups (n = 6/group) received either 90 mg/kg MgCl2/100 μL or saline per os (systemic) or 500 μg/25 μL MgCl2 or saline intra-articularly (i.a.) 30 min prior to Zy. Results MgCl2 given either systemically or locally significantly reduced cell influx (p = 0.0012 and p = 0.0269, respectively), pain (p = 0.0005 and p = 0.0038, respectively), and intra-articular IL-1 level (p = 0.0391), as compared to saline. Systemic MgCl2 significantly decreased NFκB (p < 0.05) immmunoexpression, as compared to saline. Conclusion MgCl2 given systemically or locally displayed anti-inflammatory activity in a severe acute arthritis model reducing cell influx, pain, and cytokine release. MgCl2 operates at least partially via inhibiting NFκB activation. This is the first in vivo demonstration that MgCl2 decreases cytokine release in arthritis, prompting reduction of inflammation and pain relief. evidence MgCl diseases severity antiinflammatory anti inflammatory 01 0 1 0. mg25μL mgμL mg 25μL Zy (Zy knees test IL1 IL (IL)- h (NFκB TNFα. TNFα TNF α. α (TNF)-α n 6/group 6group group 9 mgkg kg MgCl2100 100 MgCl2/10 systemic (systemic 50 μg25 μg 25 μg/2 intraarticularly intra articularly i.a. ia i (i.a. 3 00012 0012 0.001 00269 0269 0.0269 respectively, respectively , respectively) 00005 0005 0.000 00038 0038 0.0038 intraarticular articular IL- 0.0391, 00391 0.0391 0391 0.0391) 0.05 005 05 immmunoexpression activation (IL) MgCl210 10 MgCl2/1 5 μg2 2 μg/ i.a (i.a 0001 001 0.00 0026 026 0.026 0000 000 0003 003 0.003 0039 0.039 039 0.0 00 (IL MgCl21 MgCl2/ 002 02 0.02 0.03 03

Abstract This systematic review aimed to answer the focused question: “What are the benefits of subgingival periodontal therapy on blood hematological and biochemical index, biomarkers of inflammation and oxidative stress, quality of life, and periodontal pathogen counts in patients with obesity and periodontitis?”. A systematic literature search was performed in six databases: PubMed, Embase, LILACS, Web of Science, Cochrane and SCOPUS and other sources, and a manual search was conducted as well. Inclusion criteria were randomized and non-randomized clinical trials, and before-and-after studies on patients with obesity subjected to periodontal therapy. The results were synthesized qualitatively. Risk of bias within studies was assessed using RoB 2 and ROBINS-I tools. The certainty of evidence was evaluated following the GRADE approach. Three randomized controlled trials and 15 before-and-after studies were included. Randomized controlled trials were considered to have a low risk of bias, as compared to before-and-after studies assessed as having low, serious, and critical risks of bias. Non-surgical periodontal therapy plus azithromycin, chlorhexidine, and cetylpyridinium chloride reduced blood pressure and decreased serum levels of HbA1c, hsCRP, IL-1β, and TNF-α. Salivary resistin level also decreased in patients with obesity and periodontitis after therapy and chlorhexidine mouth rinse. Before-and-after data suggest an improvement in total cholesterol, LDL, triglycerides, insulin resistance, C3, GCF levels of TNF-α, chemerin, vaspin, omentin-1, visfatin, 8-OHdG, and periodontal pathogen counts after therapy. question What index stress life periodontitis. . periodontitis?” databases PubMed Embase LILACS Science sources well nonrandomized non beforeandafter before qualitatively ROBINSI ROBINS I tools approach 1 included serious Nonsurgical Non surgical azithromycin HbA1c HbAc HbA c hsCRP IL1β, IL1β ILβ IL 1β, 1β β IL-1β TNFα. TNFα TNF α. α TNF-α rinse Beforeandafter Before cholesterol LDL triglycerides resistance C3 C TNFα, α, chemerin vaspin omentin1, omentin1 omentin 1, omentin-1 visfatin 8OHdG, 8OHdG OHdG 8 OHdG, 8-OHdG periodontitis? omentin-

RESUMO Este estudo teve o objetivo de avaliar a adição de diferentes concentrações de IGF-I e insulina a diluidores, à base de gema de ovo, para melhorar a criopreservação do sêmen bovino. Dois experimentos foram desenvolvidos para avaliar os efeitos dos aditivos em dois diluidores comerciais: Botubov® (Experimento 1) e Triladyl® (Experimento 2), ambos com o mesmo delineamento. Foram utilizados três ejaculados de quatro touros (n=12). Cada ejaculado foi dividido em sete frações para diluição (60x106espermatozoides/mL), nos seguintes tratamentos: CON: somente diluidor; IGF100: 100ng/mL de IGF-I; IGF200: 200ng/mL de IGF-I; INS150: 150µUI/mL de insulina; INS200: 200µUI/mL de insulina; ASS1: 100ng/mL de IGF-I + 150µUI/mL de insulina; ASS2: 200ng/mL de IGF-I + 200µUI/mL de insulina. O sêmen foi criopreservado por sistema automatizado. Após a criopreservação, o sêmen foi avaliado quanto à motilidade espermática por CASA e quanto às membranas espermáticas (plasmática, acrossomal e mitocondrial) por sondas fluorescentes (H342, PI, FITC-PSA e JC-1). Para o diluidor Botubov®, INS150 foi mais eficiente em preservar motilidades total e progressiva, VCL, BCF, integridade da membrana plasmática e potencial mitocondrial. Resposta semelhante foi observada quando a insulina foi adicionada ao diluidor Triladyl®, INS150 foi mais eficiente na preservação da motilidade, integridade das membranas e potencial mitocondrial quando comparado aos demais grupos. Assim, a adição de 150µUI/mL de insulina aos diluidores, independentemente da composição, contribui para melhor criopreservação dos espermatozoides bovinos. IGFI IGF I ovo bovino comerciais Botubov Experimento 1 Triladyl 2, 2 , 2) delineamento n=12. n12 n n=12 . 12 (n=12) 60x106espermatozoides/mL, 60x106espermatozoidesmL xespermatozoidesmL 60x106espermatozoides/mL 60x106espermatozoides mL x (60x106espermatozoides/mL) tratamentos CON IGF100 100ngmL ngmL 100ng ng IGF200 200ngmL 200ng INS 150µUImL µUImL 150µUI µUI INS200 200µUImL 200µUI ASS1 ASS ASS2 automatizado plasmática, (plasmática H342, H342 H (H342 PI FITCPSA FITC PSA JC1. JC1 JC JC-1) INS15 progressiva VCL BCF grupos Assim composição bovinos n1 n=1 (n=12 espermatozoidesmL xespermatozoides (60x106espermatozoides/mL IGF10 IGF20 INS20 H34 (H34 JC-1 INS1 n= (n=1 IGF1 IGF2 INS2 H3 (H3 JC- (n= (H (n

ABSTRACT This study aimed to evaluate the addition of different concentrations of IGF-I and insulin to egg yolk-based extender to improve bovine semen cryopreservation. Two experiments were developed to evaluate the effects of the additives in two commercial extenders, Botubov® (Experiment 1) and Triladyl® (Experiment 2), both with the same design. Three ejaculates from four bulls (n = 12) were used. Each ejaculate was divided into seven equal fractions for dilution (60x106 spermatozoa/mL) in the following treatments: CON: extender only; IGF100: IGF-I 100ng/mL; IGF200: IGF-I 200ng/mL; INS150: insulin 150µUI/mL; INS200: insulin 200µUI/mL; ASS1: IGF-I 100ng/mL + insulin 150µUI/mL; ASS2: IGF-I 200ng/mL + insulin 200µUI/mL. Semen was cryopreserved by an automated system. Post-thawed sperm were evaluated regarding motility by CASA (Computer-assisted sperm analysis), and membranes by fluorescent probes (H342, PI, FITC-PSA and JC-1). For Botubov® extender, INS150 was more efficient in preserving total and progressive motility, VCL, BCF, plasma and mitochondrial membranes. A similar response was seen when insulin was added to the Triladyl® extender, INS150 was more efficient in preserving sperm motility, plasma membrane integrity and mitochondrial potential. Thus, the addition of insulin 150µUI/mL, regardless of the composition of the extender, contributes to better preserving bovine sperm from the cryopreservation effects. IGFI IGF I yolkbased yolk based extenders Botubov Experiment 1 Triladyl 2, 2 , 2) design n 12 used 60x106 x (60x10 spermatozoa/mL spermatozoamL spermatozoa mL treatments CON only IGF100 100ngmL ngmL 100ng ng IGF200 200ngmL 200ng INS 150µUI/mL 150µUImL µUImL 150µUI µUI INS200 200µUI/mL 200µUImL 200µUI ASS1 ASS ASS2 system Postthawed Post thawed Computerassisted Computer assisted analysis, analysis analysis) H342, H342 H (H342 PI FITCPSA FITC PSA JC1. JC1 JC . JC-1) INS15 VCL BCF potential Thus 60x10 (60x1 IGF10 IGF20 INS20 H34 (H34 JC-1 INS1 60x1 (60x IGF1 IGF2 INS2 H3 (H3 JC- 60x (H

This article addresses the initial teacher training involving students from a Bachelor's Degree Program in Mathematics in the Supervised Internship I course. In this context, we disclose in this present article how the students collectively developed tasks, according to the perspective of Technological Pedagogical Content Knowledge (TPACK), through the programming of four tasks named: "Circumference," "Pentagon," "Hexagon," and "Equilateral Triangle," with the support of Educational Robotics. Due to the COVID-19 pandemic, during our research, the students utilized the Open Roberta platform with the purpose of constructing geometric figures. Through the utilization of Open Roberta, the tasks were collectively developed by the students to enhance their Robotics and Mathematics Knowledge. Throughout their experiences in the internship context, we observed that the students managed to integrate Robotic and Mathematical Knowledge in task development. Thus, through the execution of tasks supported by online robotics, this formative stage empowered the future educators to be well-equipped for a pedagogical approach aligned with the demands of 21st-century education.

Este artículo aborda la formación inicial de docentes con las estudiantes de un Curso de Licenciatura en Matemáticas en la asignatura de Práctica Supervisada I. En este contexto, desvelamos en este presente artículo cómo las estudiantes desarrollaron de manera colectiva algunas tareas, según la perspectiva del Conocimiento Tecnológico Pedagógico del Contenido (TPACK), a través de la programación de cuatro tareas denominadas: "Circunferencia", "Pentágono", "Hexágono" y "Triángulo Equilátero", con el apoyo de la Robótica Educativa. Debido a la pandemia causada por el COVID-19, durante nuestra investigación, las estudiantes utilizaron la plataforma Open Roberta con el propósito de construir figuras geométricas. Mediante el uso de Open Roberta, las tareas fueron desarrolladas de manera colectiva por las estudiantes para desarrollar su Conocimiento en Robótica y Matemáticas. Durante las experiencias en el contexto de la práctica, observamos que las estudiantes lograron integrar el Conocimiento en Robótica y Matemáticas en la elaboración de las tareas. De esta manera, a través de la ejecución de tareas respaldadas por la robótica en línea, esta etapa formativa capacitó a las futuras educadoras para estar preparadas para un enfoque pedagógico alineado con las demandas de la educación en el siglo XXI.

Este artigo aborda a formação inicial de professores com as estagiárias de um Curso de Licenciatura em Matemática na disciplina de Estágio Supervisionado I. Neste contexto, revelamos no presente artigo, como as estagiárias desenvolveram coletivamente alguma tarefas, segundo a perspectiva da Conhecimento Tecnológico Pedagógico do Conteúdo (TPACK), a partir da programação de quatro tarefas, denominadas como: Circunferência, Pentágono, Hexágono, Triângulo Equilátero com o apoio da Robótica Educacional. Devido a pandemia causada pelo COVID-19, durante a nossa pesquisa as estagiárias fizeram uso da plataforma do Open Roberta com o próposito de construir as figuras geométricas. Com o o uso do Open Roberta, as tarefas foram desenvolvidas coletivamente pelas estagiárias para que desenvolvessem o Conhecimento de Robótica e Matemática. Durante as vivências no contexto do estágio, observamos que estagiárias conseguiram integrar o Conhecimento de Robótica e Matemática na elaboração das tarefas. Desse modo, por intermédio da execução das tarefas com o suporte da robótica online, essa etapa formativa capacitou as futuras educadoras a estarem aptas a uma abordagem pedagógica alinhada com as demandas da educação no século XXI.

Resumen Este artículo tiene como objetivo reflexionar sobre las regulaciones sobre las formas de maternidad a las que han estado expuestas mujeres de diferentes generaciones de una misma familia en las últimas décadas en el contexto brasileño. Para ello, explora narrativas de madres e hijas; con el fin de analizar lo que dicen sobre su maternidad y los discursos que permearon sus prácticas. Parto de la premisa de que la figura materna se moraliza a través de ideas de género y generación, que también generan desigualdades y resistencias por parte de quienes madres. El material de campo fue producido entre 2020 y 2022, a través de entrevistas en profundidad a mujeres urbanas y de clase media, que en ese momento tenían entre 60-70 años y 30-40 años y eran de diferentes regiones de Brasil. Las obras literarias recientes, más específicamente las novelas y ficción escritas por mujeres y sobre conflictos entre madres e hijas, funcionarán como un fondo que integra y también ayuda a interpretar los hallazgos de la investigación de campo. Entonces, al final, tomando estas relaciones entre mujeres, podemos reflexionar sobre la configuración actual de la idea de generación, de los pactos de cuidados y sus rupturas, así como -finalmente- sobre cómo las modulaciones de la maternidad importan en estos procesos. . brasileño ello hijas prácticas generación 202 2022 media 6070 60 70 60-7 3040 30 40 30-4 Brasil recientes Entonces final rupturas finalmente -finalmente procesos 20 607 6 7 60- 304 3 4 30- 2

Resumo Este artigo se dispõe a refletir sobre as regulações dos modos de maternar às quais mulheres de diferentes gerações de uma mesma família estiveram expostas nas últimas décadas no contexto brasileiro. Para isso, explora narrativas de mães e filhas; de forma a analisar o que contam sobre sua maternidade e sobre os discursos que as atravessaram em suas práticas. Parto da premissa de que a figura materna é moralizada através das ideias de gênero e de geração, que geram também desigualdades e resistências por parte daquelas que maternam. O material de campo foi produzido entre 2020 e 2022, por meio de entrevistas em profundidade com mulheres urbanas e de classe média, que na época tinham entre 60-70 anos e 30-40 anos e eram de diversas regiões do Brasil. Obras literárias recentes, mais especificamente romances e ficções escritos por mulheres e sobre conflitos entre mães e filhas, funcionarão como pano de fundo que integra e também nos ajuda a interpretar os achados da pesquisa de campo. Para, ao final, tomando essas relações entre mulheres, podermos refletir sobre a atual conformação das ideias de geração, de pactos de cuidado e suas rupturas, bem como - por último - sobre de que formas as modulações da maternidade importam nesses processos. brasileiro isso filhas práticas geração maternam 202 2022 média 6070 60 70 60-7 3040 30 40 30-4 Brasil recentes final rupturas processos 20 607 6 7 60- 304 3 4 30- 2

Abstract This article aims to reflect on the regulations on the ways of mothering to which women from different generations of the same family have been exposed in recent decades in the Brazilian context. To do this, it explores narratives of mothers and daughters; in order to analyze what they say about their motherhood and the discourses that permeated their practices. I start from the premise that the maternal figure is moralized through ideas of gender and generation, which also generate inequalities and resistance on the part of those who mother. The field material was produced between 2020 and 2022, through in-depth interviews with urban and middle-class women, who at the time were between 60-70 years old and 30-40 years old and were from different regions of Brazil. Recent literary works, more specifically novels and fiction written by women and about conflicts between mothers and daughters, will function as a background that integrates and also helps us interpret the findings of the field research. So, in the end, taking these relationships between women, we can reflect on the current configuration of the idea of generation, of care pacts and their ruptures, as well as - finally - on how the modulations of motherhood matter in these processes. context this daughters practices generation mother 202 2022 indepth depth middleclass middle class 6070 60 70 60-7 3040 30 40 30-4 Brazil works research So end ruptures processes 20 607 6 7 60- 304 3 4 30- 2

RESUMO Pesquisas que quantificam o estoque de carbono em matas ciliares destacam-se pela apresentação de serviços ambientais que essas florestas oferecem e assim minimizam os efeitos das mudanças climáticas. Objetivou-se com a realização deste trabalho: i) quantificar o estoque de carbono presente na biomassa acima do solo das espécies presentes em áreas de mata ciliar; ii) ranquear as espécies pelo índice de valor de importância ampliado (IVIA) em relação à análise fitossociológica padrão, pelo índice de valor de importância (IVI). Os dados utilizados no estudo foram obtidos a partir de um inventário realizado em áreas de vegetação ripária, região sudoeste do estado de Goiás. Estimou-se a biomassa da madeira de cada árvore para todas as espécies e posteriormente a estimativa de estoque de carbono (Mg.ha-1) por hectare na fitofisionomia. A mata ciliar possui alta capacidade de estocar carbono e a incorporação dessa variável e o ranqueamento das espécies pelo índice de importância ampliado pode ser utilizado como razão para conservação e preservação das matas ciliares, bem como um critério na escolha de espécies com maior potencial de estoque de carbono para recuperação de áreas degradadas. destacamse destacam se climáticas Objetivouse Objetivou trabalho i ii IVIA (IVIA padrão IVI. IVI . (IVI) ripária Goiás Estimouse Estimou Mg.ha1 Mgha1 Mgha Mg.ha 1 Mg ha (Mg.ha-1 fitofisionomia degradadas (IVI ha1 (Mg.ha- (Mg.ha

ABSTRACT Research that aims to quantify the carbon stock in riparian forests underscores the environmental services of these forests to minimize the effects of climate change. The objective of this work was to i) quantify the carbon stock present in the above-ground biomass of the species present in areas of riparian forest and ii) rank species by the expanded importance value index (IVIA) in relation to a standard phytosociological analysis by the importance value index (IVI). The data used in the study were taken from an inventory conducted in areas of riparian vegetation in the southwestern region of the state of Goiás. The wood biomass of each tree was estimated for all species, with a later estimate of carbon stock (Mg.ha-1) per hectare in the phytophysiognomy. The riparian forest has a high capacity to store carbon. Incorporation of this variable and ranking of species by the expanded importance index can be a reason to conserve and preserve riparian forests, as well as a criterion in the choice of species with greater potential to stock carbon for the recovery of degraded areas. change i aboveground above ground ii IVIA (IVIA IVI. IVI . (IVI) Goiás Mg.ha1 Mgha1 Mgha Mg.ha 1 Mg ha (Mg.ha-1 phytophysiognomy (IVI ha1 (Mg.ha- (Mg.ha