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1.
[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio
Simões, Marcus V.
Correia, Edileide de Barros
Marcondes-Braga, Fabiana G.
Coelho-Filho, Otavio Rizzi
Mesquita, Cláudio Tinoco
Mathias-Junior, Wilson
Rochitte, Carlos Eduardo
Ramires, Felix José Alvarez
Alves, Silvia Marinho Martins
Montera, Marcelo Westerlund
Lopes, Renato Delascio
Oliveira-Junior, Mucio Tavares
Scolari, Fernando L.
Avila, Walkiria Samuel
Canesin, Manoel Fernandes
Bacal, Fernando
Bocchi, Edimar Alcides
Moura, Lídia Ana Zytynski
Saad, Eduardo Benchimol
Scanavacca, Mauricio I.
Valdigem, Bruno Pereira
Cano , Manuel Nicolas
Abizaid , Alexandre
Ribeiro, Henrique Barbosa
Lemos-Neto, Pedro Alves
Ribeiro, Gustavo Calado de Aguiar
Jatene, Fabio Biscegli
Dias, Ricardo Ribeiro
Beck-da-Silva, Luis
Rohde, Luis Eduardo P.
Bittencourt, Marcelo Imbroinise
Pereira, Alexandre
Krieger, José Eduardo
Villacorta, Humberto
Martins, Wolney de Andrade
Figueiredo-Neto, José Albuquerque de
Cardoso , Juliano Novaes
Pastore, Carlos Alberto
Jatene, Ieda Biscegli
Tanaka, Ana Cristina Sayuri
Hotta, Viviane Tiemi
Romano, Minna Moreira Dias
Albuquerque, Denilson Campos de
Mourilhe-Rocha, Ricardo
Hajjar, Ludhmila Abrahão
Brito, Fabio Sandoli de
Caramelli , Bruno
Calderaro, Daniela
Farsky, Pedro Silvio
Colafranceschi , Alexandre Siciliano
Pinto, Ibraim Masciarelli
Vieira , Marcelo Luiz Campos
Danzmann, Luiz Claudio
Barberato , Silvio Henrique
Mady, Charles
Martinelli-Filho, Martino
Torbey , Ana Flavia Malheiros
Schwartzmann, Pedro Vellosa
Macedo, Ariane Vieira Scarlatelli
Ferreira , Silvia Moreira Ayub
Schmidt, Andre
Melo , Marcelo Dantas Tavares de
Lima-Filho, Moysés Oliveira
Sposito, Andrei C.
Brito, Flavio de Souza
Biolo, Andreia
Madrini-Junior, Vagner
Rizk, Stéphanie Itala
Mesquita, Evandro Tinoco
A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE. Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).
La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).
Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.
2.
Influence of Teas on Phospholipase A2 and Protease Activity in the Context of Blood Hemostasis-Related Processes A HemostasisRelated Hemostasis Related
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Carapiá, Mateus Santos
; Oliveira, Daniela Aparecida
; Trento, Marcus Vinicius Cardoso
; Marcussi, Silvana
; Abreu, Tatiane Silva de
; Cesar, Pedro Henrique Souza
; Braga, Mariana Aparecida
.
Abstract Tea is identified as the second most consumed drink in the world, and its frequent intake is related to several benefits to human health, considering its antimutagenic, anticarcinogenic, antimicrobial, anti-inflammatory, antihistamine, diuretic, calming, and above all, antioxidant effects. These effects are often associated with the action of the phenolic compounds contained in these infusions. In Brazil, among the most consumed infusions are the teas of chamomile (Matricaria chamomilla L.), lemongrass (Cymbopogon citratus (D.C.) Stapf), lemon balm (Melissa officinalis L.), anise (Pimpinella anisum L.), yerba mate (Ilex paraguariensis A. St.-Hil), peppermint (Mentha piperita L.), and green/black tea (Camellia sinensis L.). Therefore, said popularity is the reason why the mentioned species were chosen to be evaluated on inflammatory enzymes. The activity of phospholipases A2 was reduced by more than 25% after treatment with black tea and yerba mate. The most significant inhibition of protease activity was observed after incubation with black tea (40.74%), green tea (31.48%) and yerba mate (25.93%). Infusions of black and green tea reduced hemolysis in semisolid and liquid media, and for the latter, reductions of up to 50% of hemolytic activity were observed, indicating an anti-inflammatory potential of the samples. Plasma incubations with green tea, black tea and lemon balm and subsequent addition of venom (1:10 ratio; tea:PBS, v:v) prolonged the coagulation time of citrated plasma by approximately twice compared to the positive control. All controls with pure tea had a thrombolytic character, in higher proportions than the venom control, especially chamomile (273.55% dissolution). Phenolic compounds derived from phenolic acids, flavonoids, and tannins are identified as the main agents that promote the biological effects observed in this study. This is mainly due to their anti-catalytic properties exerted on inflammatory enzymes and as chelating agents of enzymatic co-factors. The evaluated teas showed potential for nutraceutical use, thus pointing to the possibility of use as an adjuvant in the treatment of diseases linked to hemostasis. world health antimutagenic anticarcinogenic antimicrobial antiinflammatory, antiinflammatory anti inflammatory, antihistamine diuretic calming all Brazil Matricaria L., L L. , L.) Cymbopogon D.C. DC D C (D.C. Stapf, Stapf Stapf) Melissa Pimpinella Ilex A St.Hil, StHil St. Hil St St.-Hil) Mentha greenblack Camellia L.. . Therefore 25 40.74%, 4074 40.74% 40 74 (40.74%) 31.48% 3148 31 48 (31.48% 25.93%. 2593 25.93% 93 (25.93%) media latter 50 samples 110 1 10 (1:1 ratio teaPBS, teaPBS PBS, PBS tea:PBS vv v v:v control character 273.55% 27355 273 55 (273.55 dissolution. dissolution dissolution) acids flavonoids study anticatalytic catalytic cofactors. cofactors co factors. factors co-factors hemostasis D.C (D.C St.Hil St.-Hil 2 407 40.74 4 7 (40.74% 31.48 314 3 (31.48 259 25.93 9 (25.93% 5 11 (1: 273.55 2735 27 (273.5 40.7 (40.74 31.4 (31.4 25.9 (25.93 (1 273.5 (273. 40. (40.7 31. (31. 25. (25.9 ( 273. (273 (40. (31 (25. (27 (40 (3 (25 (2 (4
3.
Diretriz sobre Diagnóstico e Tratamento da Cardiomiopatia Hipertrófica – 2024 202 20 2
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Fernandes, Fabio
; Simões, Marcus V.
; Correia, Edileide de Barros
; Marcondes-Braga, Fabiana Goulart
; Coelho-Filho, Otavio Rizzi
; Mesquita, Cláudio Tinoco
; Mathias Junior, Wilson
; Antunes, Murillo de Oliveira
; Arteaga-Fernández, Edmundo
; Rochitte, Carlos Eduardo
; Ramires, Felix José Alvarez
; Alves, Silvia Marinho Martins
; Montera, Marcelo Westerlund
; Lopes, Renato Delascio
; Oliveira Junior, Mucio Tavares de
; Scolari, Fernando Luis
; Avila, Walkiria Samuel
; Canesin, Manoel Fernandes
; Bocchi, Edimar Alcides
; Bacal, Fernando
; Moura, Lidia Zytynski
; Saad, Eduardo Benchimol
; Scanavacca, Mauricio Ibrahim
; Valdigem, Bruno Pereira
; Cano, Manuel Nicolas
; Abizaid, Alexandre Antonio Cunha
; Ribeiro, Henrique Barbosa
; Lemos Neto, Pedro Alves
; Ribeiro, Gustavo Calado de Aguiar
; Jatene, Fabio Biscegli
; Dias, Ricardo Ribeiro
; Beck-da-Silva, Luis
; Rohde, Luis Eduardo Paim
; Bittencourt, Marcelo Imbroinise
; Pereira, Alexandre da Costa
; Krieger, José Eduardo
; Villacorta Junior, Humberto
; Martins, Wolney de Andrade
; Figueiredo Neto, José Albuquerque de
; Cardoso, Juliano Novaes
; Pastore, Carlos Alberto
; Jatene, Ieda Biscegli
; Tanaka, Ana Cristina Sayuri
; Hotta, Viviane Tiemi
; Romano, Minna Moreira Dias
; Albuquerque, Denilson Campos de
; Mourilhe-Rocha, Ricardo
; Hajjar, Ludhmila Abrahão
; Brito Junior, Fabio Sandoli de
; Caramelli, Bruno
; Calderaro, Daniela
; Farsky, Pedro Silvio
; Colafranceschi, Alexandre Siciliano
; Pinto, Ibraim Masciarelli Francisco
; Vieira, Marcelo Luiz Campos
; Danzmann, Luiz Claudio
; Barberato, Silvio Henrique
; Mady, Charles
; Martinelli Filho, Martino
; Torbey, Ana Flavia Malheiros
; Schwartzmann, Pedro Vellosa
; Macedo, Ariane Vieira Scarlatelli
; Ferreira, Silvia Moreira Ayub
; Schmidt, Andre
; Melo, Marcelo Dantas Tavares de
; Lima Filho, Moysés Oliveira
; Sposito, Andrei C.
; Brito, Flávio de Souza
; Biolo, Andreia
; Madrini Junior, Vagner
; Rizk, Stephanie Itala
; Mesquita, Evandro Tinoco
.
4.
Linfoma anaplásico de grandes células T associado ao uso de implantes (BIA-ALCL): relato de caso BIAALCL BIA ALCL (BIA-ALCL) (BIA-ALCL
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PEPPE NETO, ANTÔNIO DE PÁDUA
; MARINS, ANDRE LUIZ MONTEIRO DOS SANTOS
; DAGOSTIN, MARIA JÚLIA FRITZEN
; FABRIS, MARIA JÚLIA CARDOSO
; STAHL, BÁRBARA RODRIGUES DE SOUSA
; MAFRA, MARCUS VINÍCIUS MOURÃO
.
RESUMO Reconhecido pela Organização Mundial de Saúde em 2016, o linfoma anaplásico de grandes células associado ao implante mamário (BIA-ALCL) é um subtipo incomum de linfoma não Hodgkin de células T, que se desenvolve após a inserção de próteses mamárias. A doença é uma afecção rara que afeta cerca de uma a cada 30.000 pessoas com implante mamário texturizado. As principais manifestações clínicas são o seroma tardio, assimetria mamária, massa e contratura capsular, com frequência mais elevada do primeiro. O explante da prótese com capsulectomia total pode ser suficiente para tratar o ALCL, com ressecções estendidas a locais adjacentes, quando necessário. Entretanto, em alguns casos, é realizada a radioterapia e/ou quimioterapia adjuvante. Conclui-se que, para um diagnóstico precoce e um tratamento efetivo, mulheres com seroma de aparecimento súbito e tardio deverão realizar exames complementares para a exclusão dessa afecção, mesmo com tempo inferior à média de desenvolvimento, que é de cerca de 10,6 anos. 2016 BIAALCL BIA ALCL (BIA-ALCL T mamárias 30000 30 000 30.00 texturizado mamária capsular primeiro adjacentes necessário Entretanto casos eou ou adjuvante Concluise Conclui efetivo desenvolvimento 106 10 6 10, anos 201 3000 3 00 30.0 1 20 300 0 30. 2
ABSTRACT Recognized by the World Health Organization in 2016, breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an uncommon subtype of T-cell non-Hodgkin lymphoma that develops after the insertion of breast implants. The disease is a rare condition that affects approximately one in every 30,000 people with textured breast implants. The main clinical manifestations are late seroma, breast asymmetry, mass, and capsular contracture, with a higher frequency of the former. Explantation of the prosthesis with total capsulectomy may be sufficient to treat ALCL, with resections extended to adjacent sites when necessary. However, in some cases, adjuvant radiotherapy and/or chemotherapy is performed. It is concluded that, for an early diagnosis and effective treatment, women with sudden and late-onset seroma should undergo additional tests to exclude this condition, even with a shorter development time than the average, which is around 10.6 years. 2016 implantassociated implant associated BIAALCL BIA ALCL (BIA-ALCL Tcell T nonHodgkin non Hodgkin implants 30000 30 000 30,00 asymmetry mass contracture former necessary However cases andor or performed treatment lateonset onset average 106 10 6 10. years 201 3000 3 00 30,0 1 20 300 0 30, 2
5.
Performance of Recombinant Nucleocapsid Protein-Based Constructs for Serological Diagnosis of SARS-CoV-2 Infection ProteinBased Protein Based SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- SARS-CoV
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Oliveira, Natasha Rodrigues de
; Santos, Francisco Denis Souza
; Seixas Neto, Amilton Clair Pinto
; Barbosa, Liana Nunes
; Bilhalva, Miguel Andrade
; Costa, Ana Vitória
; Donassolo, Rafael Amaral
; Rodrigues, Rafael Rodrigues
; Alves, Mariliana Luiza Ferreira
; Ferreira, Marcos Roberto Alves
; Moreira Júnior, Clóvis
; Lacerda, Marcus Vinícius Guimarães de
; Melo, Gisely Cardoso de
; Dellagostin, Odir Antônio
; McBride, Alan John Alexander
; Pinto, Luciano da Silva
; Moreira, Ângela Nunes
; Conceição, Fabrício Rochedo
.
Abstract Since the inception of COVID-19 pandemic, there has been a challenging race for the development of precise diagnostic tests. Specific SARS-CoV-2 serological assays are the main tools used to estimate the rate of past infections or herd immunity in epidemiological studies, in addition to being helpful in guiding public health management policies. In this study, an in-house ELISA based on the construct of SARS-CoV-2 nucleocapsid (N) proteins, named rCoV2, rCoV4, and rCoV7, showed diagnostic performance for the detection of IgG antibodies. Sensitivity was evaluated in serum samples from patients with mild to moderate or severe COVID-19 infections, which were collected at different time points, while specificity was evaluated using pre-pandemic sera. In samples from mild to moderate cases obtained ≥16 days after the onset of symptoms, the sensitivities for rCoV2, rCoV4, and rCoV7 were 66.7%, 75%, and 77.8%, respectively. For samples from severe cases, the sensitivity was above 80% for all constructs. All proteins showed high specificity (94-98%). Overall, rCoV7 (C-terminus N-protein portion) showed better diagnostic performance, with 62.3% sensitivity in moderate and severe cases and 96.6% specificity. The SARS-CoV-2 ELISA using N-protein-based constructs could be a promisor tool for investigate the epidemiology of COVID-19 and monitor population-level serosurveillance. COVID19 COVID 19 COVID-1 pandemic tests SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- studies policies study inhouse house N (N rCoV2 rCoV rCoV4 antibodies points prepandemic pre sera 16 ≥1 symptoms 667 66 7 66.7% 75 75% 778 77 8 77.8% respectively 80 9498%. 9498 94 98% . 98 (94-98%) Overall Cterminus C terminus Nprotein protein portion 623 62 3 62.3 966 96 6 96.6 Nproteinbased populationlevel population level serosurveillance COVID1 1 COVID- SARS-CoV ≥ 66.7 77.8 9498% 949 9 (94-98% 62. 96. 66. 77. (94-98 (94-9 (94- (94 (9 (
6.
Contextual inequalities in specialized dental public health care in Brazil
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PIRES, Ana Luiza Cardoso
; COSTA, Francine dos Santos
; D’ÁVILA, Otávio Pereira
; CARVALHO, Rodrigo Varella de
; CONDE, Marcus Cristian Muniz
; CORREA, Marcos Britto
; DEMARCO, Flávio Fernando
; CHISINI, Luiz Alexandre
.
Abstract The present study aimed to investigate the contextual inequalities of specialized public dental care (SPDC) in Brazil. The outcome was the trajectory of dental specialized production in municipalities with SPDC (from 2015 to 2017) obtained by group-based trajectory modeling. A Poisson regression model was used to analyze the factors associated with the high trajectory of SPDC production. The inequality indicators for SPDC production were the slope index and the concentration index according to contextual factors. The study included 954 SPDC units distributed across 893 municipalities. Among the municipalities evaluated, 62.9% had a low trajectory of SPDC. Large-sized municipalities had the highest production (IRR = 2.84, 95%CI: 1.94–4.14) and the southern region had the lowest production (IRR = 0.73, 95%CI: 0.58–0.92). Municipalities presenting a very high human development index (HDI) showed the greatest SPDC production (IRR = 3.34, 95%CI: 1.09–10.24), as well as municipalities with the highest tertile of schooling rate (IRR = 1.23, 95%CI: 1.00–1.50). The absolute inequality was 52.1 percentage points for the average monthly wage (p < 0.001), 61.0 percentage points for the HDI (p < 0.001), -22.1 for infant mortality rate (p <0.001), and 14.8 for the schooling rate (p = 0.012). Thus, there are contextual inequalities in the Brazilian SPDC. Higher scores for social indicators were associated with better SPDC performance. (SPDC Brazil from 201 2017 groupbased group based modeling 95 89 evaluated 629 62 9 62.9 Largesized Large sized IRR 284 2 84 2.84 95%CI 95CI CI 1.94–4.14 194414 1 94 4 14 073 0 73 0.73 0.58–0.92. 058092 0.58–0.92 . 58 92 0.58–0.92) (HDI 334 3 34 3.34 1.09–10.24, 1091024 1.09–10.24 , 09 10 24 1.09–10.24) 123 23 1.23 1.00–1.50. 100150 1.00–1.50 00 50 1.00–1.50) 521 52 52. p 0.001, 0001 0.001 001 0.001) 610 61 61. 22.1 221 22 -22. <0.001, <0.001 <0.001) 148 8 14. 0.012. 0012 0.012 012 0.012) Thus performance 20 6 62. 28 2.8 1.94–4.1 19441 07 7 0.7 05809 0.58–0.9 5 33 3.3 109102 1.09–10.2 12 1.2 10015 1.00–1.5 000 0.00 22. -22 <0.00 0.01 01 2. 1.94–4. 1944 0. 0580 0.58–0. 3. 10910 1.09–10. 1. 1001 1.00–1. 0.0 -2 <0.0 1.94–4 194 058 0.58–0 1091 1.09–10 100 1.00–1 - <0. 1.94– 19 05 0.58– 109 1.09–1 1.00– <0 1.94 0.58 1.09– 1.00 1.9 0.5 1.09 1.0
7.
Assessing mobility resilience and vulnerability in the context of challenging transportation fare policies: a case study of Rio de Janeiro policies
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Santos, Tálita
; Cardoso, Marcus
; Silva, Marcelino Aurelio Vieira da
; Fernandes, Vicente Aprigliano
.
Resumo A resiliência da mobilidade urbana é um tema emergente, com a maioria dos estudos focando em desastres naturais ou distúrbios técnicos. No entanto, há uma lacuna na compreensão da resiliência e da vulnerabilidade da mobilidade urbana diante de ameaças econômicas e políticas de transporte inadequadas, principalmente em países em desenvolvimento, como o Brasil, caracterizados por desigualdade social e segregação urbana. Este estudo lança luz sobre a questão das desigualdades e da segregação urbana, com o objetivo de identificar as áreas mais vulneráveis e resilientes do Rio de Janeiro, no caso de uma crise econômica. Avaliamos a resiliência e a vulnerabilidade do sistema de transporte público usando indicadores de acessibilidade comumente usados, aplicando lógica difusa a dados de 160 distritos. Consideramos um cenário sem o programa de subsídio tarifário. Os resultados indicam que os distritos com melhor acesso a sistemas de transporte de alta capacidade e oportunidades de emprego apresentam níveis mais elevados de resiliência e menor vulnerabilidade. No entanto, o estudo também revela desigualdades socioespaciais, com valores de resiliência tendendo a ser maiores nas áreas costeiras e nos distritos centrais de negócios, exacerbando as disparidades. É evidente que enfrentar as desigualdades urbanas e a segregação requer não apenas melhorar os tempos de viagem e os sistemas de transporte, mas também considerar o impacto econômico nas populações vulneráveis e promover oportunidades de emprego descentralizadas. emergente técnicos entanto inadequadas desenvolvimento Brasil Janeiro econômica usados 16 tarifário socioespaciais negócios disparidades descentralizadas 1
Abstract Resilience of urban mobility is an emerging topic, with most studies focusing on natural disasters or technical disturbances. However, there is a gap in understanding the resilience and vulnerability of urban mobility in the face of economic threats and inadequate transport policies, particularly in developing countries such as Brazil, characterized by social inequality and urban segregation. This study sheds light on the issue of urban inequalities and segregation, aiming to identify the most vulnerable and resilient areas of Rio de Janeiro in the event of an economic crisis. We assessed the resilience and vulnerability of the public transport system with commonly used accessibility indicators, applying fuzzy logic to data from 160 districts. We considered a scenario without the fare subsidy program. The results indicate that districts with better access to high-capacity transport systems and job opportunities exhibit higher levels of resilience and lower vulnerability. However, the study also uncovers socio-spatial inequalities, with resilience values tending to be higher in coastal areas and central business districts, exacerbating disparities. Addressing urban inequalities and segregation requires not only improving travel times and transportation systems but also considering the economic impact on vulnerable populations and promoting decentralized employment opportunities. topic disturbances However policies Brazil crisis indicators 16 program highcapacity high capacity sociospatial socio spatial disparities 1
8.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
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; Marques, Antonio C.
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; Frable, Benjamin W.
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; Schoeninger, Karine
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; Soares, Karla
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; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
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; Silveira, Luis F.
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; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
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; Sekerka, Lukas
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; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
; Araújo, Marcel S. de
; Monné, Marcela L.
; Labruna, Marcelo B.
; Santis, Marcelo D. de
; Duarte, Marcelo
; Knoff, Marcelo
; Nogueira, Marcelo
; Britto, Marcelo R. de
; Melo, Marcelo R.S. de
; Carvalho, Marcelo R. de
; Tavares, Marcelo T.
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; Justo, Marcia C.N.
; Botelho, Marcia J.C.
; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
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; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
; Loeb, Marina V.
; Cohn-Haft, Mario
; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
; Rocha, Matheus dos S.
; Martins, Maurício L.
; Segura, Melissa O.
; Cardenas, Melissa Q.
; Duarte, Mércia E.
; Ivie, Michael A.
; Mincarone, Michael M.
; Borges, Michela
; Monné, Miguel A.
; Casagrande, Mirna M.
; Fernandez, Monica A.
; Piovesan, Mônica
; Menezes, Naércio A.
; Benaim, Natalia P.
; Reategui, Natália S.
; Pedro, Natan C.
; Pecly, Nathalia H.
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; Perioto, Nelson W.
; Hamada, Neusa
; Degallier, Nicolas
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; Mielke, Olaf H.H.
; Evangelista, Olivia
; Shibatta, Oscar A.
; Oliveira, Otto M.P.
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; Lima, Patricia O.V.
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; Araújo, Paula B.
; Silva, Paula K.R.
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; Garcia, Paulo C. de A.
; Passos, Paulo G.H.
; Corgosinho, Paulo H.C.
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; Boldrini, Rafael
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; Costa, Sávio C.
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ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
9.
[SciELO Preprints] - Duodenal Exclusion in the Regulation of Glycemia in Type 2 Diabetic Patients Submitted to Gastrectomy with Roux-en-Y by Gastric Cancer: Cohort Study
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Franciss , Maurice Youssef
González , Carol Viviana Serna
Barchi , Leandro Cardoso
Boueri, Myriam
Ramos , Marcus Fernando Kodama Pertille
Zilberstein , Bruno
Background: The effect of the duodenal exclusion in glycemic regulation has yet to benbsp;defined. Individuals with type 2 Diabetes Mellitus (T2DM) operated for other reasons thannbsp;obesity, represent an adequate model to analyze clinical outcomes of duodenal exclusion.nbsp;nbsp;
Objective: To analyze the changes in glycemia and pharmacotherapy for T2DM in patients undergoing gastrectomy with Roux-in-Y derivation for gastric cancer.nbsp;
Methods: An observational study was conducted in 2018 on patients who were submitted to surgery from 2001 to 2016. Medical records of 129 patients’ cohort operated in two public hospitals were analyzed retrospectively before the surgery (T0) and one year after (T1). The researchnbsp;protocol was approved by the ethics committee. The final sample was mainly represented bynbsp;women (50.5%) with a mean age of 65.5 years, and a mean body mass index of 26.5 kg/m2 SD 4.30.nbsp;nbsp;
Results: One year later, mean glucose levels of the entire sample decreased (p=0.046), but 70% of patients with glycemiagt; 100 at T0, remained with the same value in T1. Glycated hemoglobin had no significant change (p=0.988). Regarding the pharmacotherapy for T2DM,nbsp;60.7% of the sample had no change. However, 6.7% had discontinuation of the medication with the improvement of T2DM. The multivariate model by classification and decision tree method (CART) found as predictors of change innbsp;DM2 medication, age (lt;62.5 years) and a body mass index (gt; 30.2 kg/m2) with a predictive value ofnbsp;71.4%.nbsp;
Conclusion: There was no improvement of glycemia and pharmacotherapy in patients withnbsp;T2DM who underwent gastrectomy with Roux-en-Y reconstruction, with a body mass index below 30nbsp;kg/m2
Antecedentes: Aún no se ha definido el efecto de la exclusión duodenal en la regulación glucémica. Individuos con Diabetes Mellitus tipo 2 (DM2) operados por otras razones distintas a la obesidad, representan un modelo adecuado para analizar los resultados clínicos de la exclusión duodenal.
Objetivo: Analizar los cambios en la glucemia y la farmacoterapia para la DM2 en pacientes sometidos a gastrectomía con derivación en Y de Roux por cáncer gástrico.
Métodos: se realizó un estudio observacional en 2018 en pacientes que fueron sometidos a cirugía entre 2001 y 2016. Se analizaron retrospectivamente las historias clínicas de una cohorte de 129 pacientes operados en dos hospitales públicos antes de la cirugía (T0) y un año después (T1). El protocolo de investigación fue aprobado por el comité de ética. La muestra final estuvo representada mayoritariamente por mujeres (50,5 %) con una edad media de 65,5 años y un índice de masa corporal medio de 26,5 kg/m2 SD 4,30.
Resultados: Un año después, los niveles medios de glucosa de toda la muestra disminuyeron (p=0,046), pero el 70% de los pacientes con glucemia gt; 100 en T0, permanecieron con el mismo valor en T1. La hemoglobina glicosilada no tuvo cambios significativos (p=0,988). En cuanto a la farmacoterapia para la DM2, el 60,7% de la muestra no presentó cambios. Sin embargo, el 6,7% tuvo suspensión de la medicación con la mejoría de la DM2. El modelo multivariante por método de clasificación y árbol de decisión (CART) encontró como predictores de cambio de medicación en DM2 la edad (lt; 62,5 años) y el índice de masa corporal (gt; 30,2 kg/m2) con un valor predictivo del 71,4%.
Conclusión: No hubo mejoría de la glucemia y la farmacoterapia en pacientes con DM2 que se sometieron a gastrectomía con reconstrucción en Y de Roux, con un índice de masa corporal por debajo de 30 kg/m2
Contexto: O efeito da exclusão duodenal na regulação glicêmica ainda não foi definido. Indivíduos com Diabetes Mellitus tipo 2 (T2DM) operados por outros motivos que não obesidade, representam um modelo adequado para analisar os resultados clínicos da exclusão duodenal.
Objetivo: Analisar as alterações da glicemia e da farmacoterapia para DM2 em pacientes submetidos à gastrectomia com derivação em Y de Roux para câncer gástrico.
Métodos: Foi realizado um estudo observacional em 2018 em pacientes operados de 2001 a 2016. Os prontuários de uma coorte de 129 pacientes operados em dois hospitais públicos foram analisados retrospectivamente antes da cirurgia (T0) e um ano após (T1). O protocolo de pesquisa foi aprovado pelo comitê de ética. A amostra final foi representada principalmente por mulheres (50,5%) com idade média de 65,5 anos e índice de massa corporal médio de 26,5 kg/m2 SD 4,30.
Resultados: Um ano depois, os níveis médios de glicose de toda a amostra diminuíram (p=0,046), mas 70% dos pacientes com glicemia gt; 100 em T0, permaneceram com o mesmo valor em T1. A hemoglobina glicada não apresentou alteração significativa (p=0,988). Em relação à farmacoterapia para DM2, 60,7% da amostra não apresentou alteração. No entanto, 6,7% tiveram descontinuação da medicação com melhora do DM2. O modelo multivariado pelo método de classificação e árvore de decisão (CART) encontrou como preditores de mudança na medicação para DM2, idade (lt;62,5 anos) e índice de massa corporal (gt; 30,2 kg/m2) com valor preditivo de 71,4%.
Conclusão: Não houve melhora da glicemia e farmacoterapia em pacientes com DM2 submetidos à gastrectomia com reconstrução em Y de Roux, com índice de massa corporal abaixo de 30 kg/m2
10.
Construção e Validação do Protocolo EmpoderACO Direcionado a Pacientes em Anticoagulação Oral com Varfarina
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Barbosa, Hannah Cardoso
; Torres, Heloisa de Carvalho
; Oliveira, João Antônio de Queiroz
; Santos, Rebeca Priscila de Melo
; Costa, Josiane Moreira da
; Miranda, Leonardo Gonçalves
; Pagano, Adriana Silvina
; Praxedes, Marcus Fernando da Silva
; Martins, Maria Auxiliadora Parreiras
.
Resumo Fundamento A varfarina é um anticoagulante oral útil para prevenção de tromboembolismo, embora seja considerado fármaco de alto risco de causar eventos adversos. Considerando os desafios práticos no controle da anticoagulação oral, os pacientes poderiam se beneficiar de estratégias educacionais que visem mudança de comportamento, participação ativa no autocuidado e adesão à farmacoterapia. Objetivo Construir e validar o protocolo EmpoderACO para mudança de comportamento em pacientes em uso de varfarina. Métodos As etapas metodológicas foram: definição de conceitos e domínios do autocuidado, identificação dos objetivos, construção e seleção dos itens, avaliação da validade de conteúdo e pré-teste na população alvo. Resultados Relevância, adequação, clareza e confiabilidade interna dos itens do instrumento foram avaliadas por comitê de juízes multiprofissional pela plataforma web E-surv, obtendo-se média de concordância ≥0,91. A compreensão do instrumento pela população-alvo teve clareza adequada com média de 0,96. Conclusão O EmpoderACO poderá contribuir para qualificar o processo de comunicação entre profissionais e pacientes, melhorar a adesão ao tratamento e os resultados clínicos, podendo ser replicado nos serviços de saúde. tromboembolismo adversos farmacoterapia objetivos préteste pré teste alvo Relevância adequação Esurv, Esurv E surv, surv E-surv obtendose obtendo 091 0 91 ≥0,91 populaçãoalvo 096 96 0,96 clínicos saúde 09 9 ≥0,9 0,9 ≥0, 0, ≥0 ≥
Abstract Background Warfarin is an oral anticoagulant that is very useful in preventing thromboembolism, though it is considered a drug with a high risk of causing adverse events. Considering the practical challenges in controlling oral anticoagulation, the patients on warfarin could benefit from educational strategies aimed at behavioral changes, active participation in self-care, and adherence to drug therapy. Objective The aim was to construct and validate the EmpoderACO protocol for behavioral changes in warfarin patients. Methods The methodological steps were: definition of concepts and domains of self-care, identification of objectives, construction and selection of items, assessment of content validity, and pre-test in the target population. Results Relevance, adequacy, clarity, and internal reliability of the instrument’s items were assessed by a multidisciplinary judges committee (JC) through the E-surv web platform, obtaining an average agreement of ≥0.91. The understanding of the instrument measured by the target population revealed adequate clarity with a coefficient average of 0.96. Conclusion EmpoderACO can aid in qualifying the communication process between medical professionals and patients, as well as in improving adherence to both treatment and clinical outcomes, and can be replicated in healthcare settings. thromboembolism events anticoagulation selfcare, selfcare self care, care self-care therapy objectives validity pretest pre test Relevance adequacy instruments s JC (JC Esurv E surv platform 091 0 91 ≥0.91 096 96 0.96 outcomes settings 09 9 ≥0.9 0.9 ≥0. 0. ≥0 ≥
11.
Factors affecting successful antituberculosis treatment: a single-center experience treatment singlecenter single center
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Gonçalves, Marcella Cardoso
; Aguiar, Amanda Aparecida Silva de
; Biadola, Ana Paula
; Mazaro, Paulo José Mascarenhas
; Rodrigues, Marcus Vinícius Pimenta
; Prado, Rosana Leal do
; Peresi-Lordelo, Eliana
.
SUMMARY OBJECTIVE: The identification of factors that influence a favorable antituberculosis treatment outcome could be of great use for the promotion of specific health actions to increase the success rate. Thus, the objective of this study was to investigate the factors affecting successful antituberculosis treatment in patients seen at a reference service in the Western region of São Paulo State/Brazil. METHODS: A retrospective study was carried out from 2010 to 2016 based on the data obtained from the Notification Disease Information System of TB patients treated at a reference service in Brazil. The study included patients with treatment outcomes and excluded those from the penitentiary system or with resistant or multidrug-resistant TB. Patients were categorized as having a successful (cured) or unsuccessful (treatment default and death) treatment outcome. The association between TB treatment outcomes and social and clinical factors was analyzed. RESULTS: A total of 356 cases of TB were treated between 2010 and 2016. Among the cases, the majority were cured and the overall treatment success rate was 85.96%, with a range between 80.33% (2010) and 97.65% (2016). After the exclusion of resistant/multidrug-resistant TB, 348 patients were analyzed. In the final logistic regression model analysis, education less than 8 years (OR 1.66; p<0.0001) and people living with human immunodeficiency virus/acquired immunodeficiency syndrome (OR 0.23; p<0.0046) were found to be significantly related to an unfavorable treatment outcome. CONCLUSION: Low education and being a person living with human immunodeficiency virus/acquired immunodeficiency syndrome are vulnerability factors that can affect the successful outcome of antituberculosis treatment. OBJECTIVE Thus StateBrazil State Brazil State/Brazil METHODS 201 multidrugresistant multidrug (cured death analyzed RESULTS 35 8596 85 96 85.96% 8033 80 33 80.33 (2010 9765 97 65 97.65 . (2016) resistant/multidrugresistant resistantmultidrugresistant resistant/multidrug 34 analysis OR 1.66 166 1 66 p<0.0001 p00001 p 0 0001 virusacquired virus acquired 0.23 023 23 p<0.0046 p00046 0046 CONCLUSION 20 3 859 9 85.96 803 80.3 (201 976 6 97.6 (2016 resistantmultidrug 1.6 16 p<0.000 p0000 000 0.2 02 2 p<0.004 p0004 004 85.9 80. (20 97. 1. p<0.00 p000 00 0. 85. (2 p<0.0 p00 ( p<0. p0 p<0 p<
12.
EFEITO DA PADRONIZAÇÃO DOS CRITÉRIOS DE OBSERVAÇÃO E DE AVALIAÇÃO DA TÉCNICA DA BRAÇA DO NADO CRAWL NA CONFIABILIDADE INTER E INTRA AVALIADORES
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Peres, Marcus Vinícius Sampaio
; Nogueira, Francine Caetano de Andrade
; Ramos, Waldyr Mendes
; Cardoso, Tamiris da Silva
; Salgado Filho, Leandro Nogueira
; Tucher, Guilherme
.
RESUMO Esse estudo teve por objetivo avaliar o efeito da padronização dos critérios de observação e de avaliação da técnica da braçada do nado crawl na confiabilidade inter e intra avaliadores para uma proposta de lista de observação. Dois professores e dois treinadores de natação competitiva com formação acadêmica diferentes foram responsáveis por avaliar a técnica da braçada do nado crawl de 44 nadadores por meio de vídeo. Cada nadador realizou um percurso de 25m em velocidade confortável tendo seu deslocamento gravado nos planos lateral e frontal, ambos submersos e fora d’água, nos 10 m finais da piscina. No percurso de filmagem os nadadores não realizaram a respiração lateral. Somente o movimento realizado pelo braço direito foi foco de observação dos avaliadores e com base em uma lista de verificação. Após as filmagens os avaliadores participaram de três etapas: na primeira etapa houve uma intervenção para padronização dos critérios de observação e de avaliação. Na segunda etapa testou-se a concordância inter-avaliadores e, na terceira, a concordância intra-avaliador. Na segunda etapa do estudo a concordância variou de pequeno a baixa (k=0,08 e k=0,38). Na terceira etapa alguns avaliadores apresentaram concordância pobre e baixa (k=-0,13 e k=0,35), enquanto outros apresentaram concordância entre razoável e praticamente perfeita (k=0,64 e k=0,87). A partir dos resultados apresentados concluiu-se que a proposta de intervenção não surtiu o efeito desejado de padronização dos critérios de observação e avaliação entre os avaliadores. 4 vídeo frontal dágua, dágua d água, água d’água 1 piscina verificação etapas testouse testou se interavaliadores intraavaliador. intraavaliador avaliador. avaliador intra-avaliador k=0,08 k008 k 0 08 (k=0,0 k=0,38. k038 k=0,38 . 38 k=0,38) k=0,13 k013 k= 0,13 13 (k=-0,1 k=0,35, k035 k=0,35 , 35 k=0,35) k=0,64 k064 64 (k=0,6 k=0,87. k087 k=0,87 87 k=0,87) concluiuse concluiu k=0,0 k00 (k=0, k03 k=0,3 3 k=0,1 k01 013 0,1 (k=-0, k=0,6 k06 6 k08 k=0,8 8 k=0, k0 (k=0 01 0, (k=-0 k=0 (k= (k=- (k
ABSTRACT This study aimed to assess the effect of standardizing observation and rating criteria for the front crawl stroke technique on inter- and intra-rater reliability in order to propose an observation list. Two teachers and two competitive swimming coaches with different academic backgrounds were responsible for evaluating the front crawl stroke technique of 44 swimmers using video. Each swimmer completed a 25m course at a comfortable speed, having their displacement recorded in the lateral and frontal planes, both submerged and out of water, in the final 10 m of the pool. Throughout the recording, the swimmers did not breath laterally. Only the movement performed by the right arm was the raters’ focus of observation and was based on a checklist. After the shooting, the raters participated in three stages: in the first stage, there was an intervention to standardize the observation and rating criteria; inter-rater agreement was tested in the second stage, while intra-rater agreement was obtained in the third. In the second stage of the study, the agreement ranged from small to low (k=0.08 and k=0.38). In the third stage, some raters showed poor and low agreement (k=-0.13 and k=0.35), while others showed agreement between reasonable and virtually perfect (k=0.64 and k=0.87). From the results presented, it was concluded that the intervention proposal did not have the desired effect of standardizing the observation and rating criteria among the raters. inter intrarater intra rater list 4 video speed planes water 1 pool recording laterally checklist shooting stages interrater k=0.08 k008 k 0 08 (k=0.0 k=0.38. k038 k=0.38 . 38 k=0.38) k=0.13 k013 k= 0.13 13 (k=-0.1 k=0.35, k035 k=0.35 , 35 k=0.35) k=0.64 k064 64 (k=0.6 k=0.87. k087 k=0.87 87 k=0.87) presented k=0.0 k00 (k=0. k03 k=0.3 3 k=0.1 k01 013 0.1 (k=-0. k=0.6 k06 6 k08 k=0.8 8 k=0. k0 (k=0 01 0. (k=-0 k=0 (k= (k=- (k
13.
Psychometric properties of the online Satisfaction with Life Scale in university students from a low-income region lowincome low income
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Cardoso, Antonio Gibran de Almeida
; Carvalho, Millena Vaz de
; Silva, Maria Isabela Alves de Almeida
; Franco, Alaiana Marinho
; Quaresma, Fernando Rodrigues Peixoto
; Maciel, Erika Da Silva
; Nascimento-Ferreira, Marcus Vinicius
.
Abstract Purpose To test the feasibility, reliability, and validity of the Satisfaction with Life Scale (SWLS) in an online format in university students from a low-income region. Methods This was a psychometric study, involving a study of reliability ( n = 117) and validity ( n = 195) in university students from a region with a Gini index of 0.56. The scale was applied at two time points with an interval of 2 weeks. This scale measures satisfaction with life based on five statements and responses ranging from 1 to 7 (strongly disagree to strongly agree). We conducted the reliability assessment using temporal stability and internal consistency and construct validity assessment by internal structure solution. Results All SWLS items showed acceptable (rho > 0.30) and significant ( p < 0.05) temporal stability and acceptable internal consistency (alpha > 0.70). In construct validity (internal structure), we identified a factor with an explained variance of 59.0% in the exploratory factor analysis. Additionally, in the confirmatory factor analysis, we identified a one-factor structure solution for SWLS with an acceptable model fitting (chi-square/degrees of freedom [ X 2/df] = 6.53; Tucker–Lewis Index [TLI] = 0.991; Comparative Fit Index [CFI] = 0.996; root mean square error of approximation [RMSEA] = 0.040; standardized root mean-squared residual [SRMR] = 0.026). Conclusion The Satisfaction with Life Scale, in the online format, is a reliable and valid tool for university students in a low-income context. feasibility (SWLS lowincome low income 117 195 056 0 56 0.56 weeks agree. agree . agree) rho 0.30 030 30 0.05 005 05 alpha 0.70. 070 0.70 70 0.70) structure, , structure) 590 59 59.0 analysis Additionally onefactor one chisquare/degrees chisquaredegrees chi square/degrees degrees 2/df 2df df 6.53 653 6 53 TuckerLewis Tucker Lewis TLI [TLI 0.991 0991 991 CFI [CFI 0.996 0996 996 RMSEA [RMSEA 0.040 0040 040 meansquared squared SRMR [SRMR 0.026. 0026 0.026 026 0.026) context 11 19 5 0.5 0.3 03 3 0.0 00 07 0.7 59. chisquare squaredegrees 6.5 65 0.99 099 99 0.04 004 04 002 0.02 02 0. 6. 0.9 09 9
14.
Emergências Relacionadas à Doença Valvar Cardíaca: Uma Revisão Abrangente da Abordagem Inicial no Departamento de Emergência Cardíaca
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Accorsi, Tarso Augusto Duenhas
; Paixão, Milena Ribeiro
; Souza Júnior, José Leão de
; Gaz, Marcus Vinicius Burato
; Cardoso, Ricardo Galesso
; Köhler, Karen Francine
; Lima, Karine De Amicis
; Tarasoutchi, Flavio
.
Resumo A doença valvar cardíaca é um problema de saúde crescente no mundo. Os pacientes com valvopatia podem apresentar diversas emergências cardiovasculares. O manejo desses pacientes é um desafio no departamento de emergência, principalmente quando a condição cardíaca prévia é desconhecida. Atualmente, recomendações específicas para o manejo inicial são limitadas. A presente revisão integrativa propõe uma abordagem baseada em evidência, de três etapas, desde a suspeita de valvopatia à beira do leito até o tratamento inicial das emergências. A primeira etapa é a suspeita de uma condição valvar subjacente com base nos sinais e sintomas. A segunda etapa consiste na tentativa de confirmação diagnóstica e avaliação da gravidade da valvopatia com exames complementares. Finalmente, a terceira etapa aborda as opções diagnósticas e terapêuticas para insuficiência cardíaca, fibrilação atrial, trombose valvar, febre reumática aguda, e endocardite infecciosa. Além disso, apresentamos imagens de exames complementares e tabelas para apoio aos médicos. mundo cardiovasculares emergência desconhecida Atualmente limitadas evidência etapas sintomas Finalmente atrial aguda infecciosa disso médicos
Abstract Valvular heart disease (VHD) is an increasing health problem worldwide. Patients with VHD may experience several cardiovascular-related emergencies. The management of these patients is a challenge in the emergency department, especially when the previous heart condition is unknown. Specific recommendations for the initial management are currently poor. This integrative review proposes an evidence-based three-step approach from bedside VHD suspicion to the initial treatment of the emergencies. The first step is the suspicion of underlying valvular condition based on signs and symptoms. The second step comprises the attempt to confirm the diagnosis and assessment of VHD severity with complementary tests. Finally, the third step addresses the diagnosis and treatment options for heart failure, atrial fibrillation, valvular thrombosis, acute rheumatic fever, and infective endocarditis. In addition, several images of complementary tests and summary tables are provided for physician support. (VHD worldwide cardiovascularrelated cardiovascular related emergencies department unknown poor evidencebased evidence threestep three symptoms Finally failure fibrillation thrombosis fever endocarditis addition support
15.
Experimental Evaluation of Chitosan Membrane and Collagen Sponge (TachoSil®) as Sealants in Cardiovascular Surgery
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Santos, Renan Nalin dos
; Cardoso, Guinea Brasil Camargo
; Cunha, Marcelo Rodrigues
; Marchi, Evaldo
; Carvalho, Marcus V. H
.
Brazilian Journal of Cardiovascular Surgery
- Journal Metrics
ABSTRACT Introduction: The objectives of this study are to experimentally evaluate the haemostatic effects of two organic substances, a membrane of chitosan and a collagen sponge coated with thrombin and human fibrinogen (TachoSil®), in sealing 7-0 needle stitches holes on the femoral arteries of rats as well as to evaluate local histological reactions. Methods: Twenty-four rats were included, and four holes were made in each common femoral artery. In the control group, haemostasis was achieved only by compression with gauze sponge; and in the two other groups, haemostasis was achieved with application of one of these two substances. Results: Membrane of chitosan and TachoSil® showed a power to reduce the time to achieve haemostasis compared with the control group (P=0.001), and the haemostatic effects of these two substances were comparable. There was lower blood loss in the groups where these two substances were used when compared with the control group, but no difference was found comparing the two substances. Conclusion: The use of these sealants did not promote more adhesion or local histological reactions when compared to the control group. Since chitosan is easy to find in nature, has a positive effect to promote haemostasis, and did not bring considerable local reactions, it might be used as a sealant in cardiovascular surgery.
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