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1.
Blood cell alterations in Colossoma macropomum juveniles caused by silver nanoparticles
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MENESES, JULIANA O.
; CUNHA, FERNANDA DOS SANTOS
; DIAS, JOEL ARTUR R.
; SOUSA, NATALINO DA COSTA
; COUTO, MÁRCIA VALÉRIA S. DO
; CUNHA, ANA FLÁVIA S. DA
; PAIXÃO, PETERSON EMMANUEL G.
; ABE, HIGO A.
; NASCIMENTO, VICTOR RUAN S.
; CARDOSO, JULIANA C.
; COSTA, LUIZ P. DA
; FUJIMOTO, RODRIGO Y.
.
Abstract This study evaluated the median lethal concentration of silver nanoparticles and their effects in fish tambaqui Colossoma macropomum. Therefore, an acute toxicity assay was carried out in completely randomized design evaluating six different concentrations of silver nanoparticles on blood parameters of tambaqui. The silver nanoparticles were produced by chemical reduction with polyvinyl alcohol (AgNP-PVA). The lethal concentration 50% (LC50) was estimated using probit regression. The blood was collected, analyzed and the data were submitted to T-test (dying x surviving fish) and Tukey test (surviving fish). An increase in glucose, hematocrit, total plasma protein, hemoglobin, erythrocytes, leukocytes, monocytes, and neutrophils as well as reduced MCV (mean corpuscular volume) in dying fish compared to surviving fish were observed. Survived fish exposed to 187.5 µg/L showed an increase in hematocrit, MCV, and MCH and a reduction in erythrocytes, total numbers of leukocyte, thrombocyte, lymphocyte, and neutrophil. The fish exposed to concentrations below 125 µg/L, had returned the blood parameter to baselines compared to control. The estimated LC50 was 165.09 µg/L and was classified as highly toxic for the fish tambaqui. In higher concentrations, it causes an acute respiratory toxicity, but in concentrations below 125 µg/L, the fish can adapt to the stressing agent. macropomum Therefore AgNPPVA. AgNPPVA AgNP PVA . (AgNP-PVA) 50 LC (LC50 regression collected Ttest T fish. glucose hematocrit protein hemoglobin erythrocytes leukocytes monocytes mean volume observed 1875 187 5 187. µgL µg L leukocyte thrombocyte lymphocyte neutrophil 12 control LC5 16509 165 09 165.0 agent (AgNP-PVA (LC5 18 1 1650 16 0 165. (LC
2.
Eco-epidemiological analysis of Rickettsia parkeri in domestic dogs and Amblyomma ovale ticks in the Atlantic rainforest of Northeast Brazil Ecoepidemiological Eco epidemiological
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Albuquerque, Michellin Pereira de
; Horta, Mauricio Claudio
; Melo, Daniele Rosa Xavier de
; Takeda, Gabriela Akemi Cardoso Gagliardi
; Arraes-Santos, Ana Isabel
; Martins, Thiago Fernandes
; Pinter, Adriano
.
Revista Brasileira de Parasitologia Veterinária
- Journal Metrics
Resumo No Brasil, a febre maculosa (FM) é causada por duas espécies de Rickettsia, ambas transmitidas por carrapatos Amblyomma: Rickettsia rickettsii, ocasionando casos graves e frequentemente fatais, e Rickettsia parkeri, que causa uma doença leve. Este estudo concentrou-se em R. parkeri em carrapatos Amblyomma ovale na região do Maciço de Baturité, Ceará, Nordeste do Brasil, área endêmica para FM com sintomas leves. Foram examinados 60 cães domésticos com acesso à floresta para carrapatos e soroprevalência de Rickettsia. Conduziu-se uma análise da paisagem em todos os fragmentos florestais dentro de 2–10 km da borda principal da floresta. No total, 125 carrapatos A. ovale foram coletados de 30 cães (50%). Testou-se o DNA de 65 carrapatos, usando-se primers de Rickettsia gênero-específico. Três (4,6%) espécimes de carrapatos testaram positivo para R. parkeri, enquanto a soroprevalência de Rickettsia entre os cães foi de 55% (33/60). Observou-se uma provável ocorrência de transmissão de Rickettsia na fragmentada Mata Atlântica, que possui 1.019 ha de terra preservada e 50,6 km de borda perimetral. As características da área permitem que cães semidomiciliados acessem fragmentos florestais, onde carrapatos A. ovale são comumente presentes. Carrapatos infectados podem parasitar cães, que então os transportam para as casas, potencialmente transmitindo bactérias causadoras da FM aos humanos. Brasil (FM rickettsii fatais leve concentrouse concentrou se R Baturité Ceará leves 6 Conduziuse Conduziu 210 2 10 2–1 total 12 A 3 50%. 50 50% . (50%) Testouse Testou usandose usando gêneroespecífico. gêneroespecífico gênero específico. específico gênero-específico 4,6% 46 4 (4,6% 55 33/60. 3360 33/60 33 (33/60) Observouse Observou Atlântica 1019 1 019 1.01 506 50, perimetral presentes casas humanos 21 2– 5 (50% 4,6 (4,6 336 33/6 (33/60 101 01 1.0 (50 4, (4, 33/ (33/6 0 1. (5 (4 (33/ ( (33 (3
Abstract In Brazil, spotted fever (SF) is caused by two species of Rickettsia, both of which are transmitted by Amblyomma ticks: Rickettsia rickettsii, which results in severe and often fatal cases, and Rickettsia parkeri, which causes a mild illness. This study focused on R. parkeri in Amblyomma ovale ticks from the Maciço de Baturité region, Ceará, Northeast Brazil, an area endemic for SF with mild symptoms. We examined 60 domestic dogs with access to the forest for ticks and Rickettsia seroprevalence. A landscape analysis was conducted in all forest patches within 2–10 km from the main forest edge. In total, 125 A. ovale ticks were collected from 30 dogs (50%). DNA from 65 ticks was tested using genus-specific Rickettsia primers. Three (4.6%) tick specimens tested positive for R. parkeri while the Rickettsia seroprevalence among the dogs was 55% (33/60). A probable occurrence of Rickettsia transmission was observed in the fragmented Atlantic rainforest, which has 1,019 ha of preserved land and 50.6 km of perimeter border. The land's characteristics allow for semi-domiciled dogs to access forest fragments, where A. ovale ticks are commonly present. Infected ticks may parasitize the dogs, which then transport the ticks into homes, potentially transmitting SF-causing bacteria to humans. Brazil (SF rickettsii cases illness R region Ceará symptoms 6 210 2 10 2–1 edge total 12 3 50%. 50 50% . (50%) genusspecific genus specific primers 4.6% 46 4 (4.6% 55 33/60. 3360 33/60 33 (33/60) rainforest 1019 1 019 1,01 506 50. border lands s semidomiciled semi domiciled fragments present homes SFcausing causing humans 21 2– 5 (50% 4.6 (4.6 336 33/6 (33/60 101 01 1,0 (50 4. (4. 33/ (33/6 0 1, (5 (4 (33/ ( (33 (3
3.
Phone call for diabetic people: protocol for a pragmatic, type 1 effectiveness-implementation hybrid clinical trial people pragmatic effectivenessimplementation effectiveness implementation
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Sala, Danila Cristina Paquier
; Costa, Paula Cristina Pereira
; Baumann, Ana A.
; Cardoso, Marília Mastrocolla de Almeida
; Horta, Ana Lucia de Moraes
; Okuno, Meiry Fernanda Pinto
.
RESUMO Objetivo: Descrever um protocolo de estudo de implementação de uma intervenção baseada em orientações educativas focadas em sete comportamentos para o autocuidado, por meio de chamadas telefônicas para pessoas com diabetes tipo 2. Método: Será conduzido um ensaio clínico randomizado pragmático híbrido tipo 1 de efetividade-implementação, com 198 pessoas com diabetes mellitus tipo 2, em insulinoterapia, do Programa de Automonitoramento Glicêmico de duas Unidades Básicas de Saúde da cidade de São Paulo e três de Campinas, situadas no estado de São Paulo. Os pacientes serão alocados na proporção 1:1 para o grupo intervenção ou controle. Ambos os grupos receberão cuidados habituais, sendo que o grupo intervenção também receberá uma chamada telefônica. Durante a chamada, os(as) enfermeiros(as) fornecerão orientações baseadas em sete comportamentos para o autocuidado, conhecidos como The ADCES7 Self-Care Behaviors™. As avaliações ocorrerão no início e após 3 e 6 meses do início do ensaio. Níveis glicêmicos e adesão aos comportamentos de autocuidado serão comparados antes e depois da intervenção por modelos de regressão linear múltiplos. Por meio de entrevistas com os participantes do grupo intervenção, serão avaliados determinantes da implementação baseados no modelo Capacidade, Oportunidade, Motivação para mudança do Comportamento (COM-B), e os desfechos de implementação viabilidade, aceitabilidade e adequação. Resultados esperados: Este estudo fornecerá evidências preliminares sobre a efetividade da orientação educativa por chamada telefônica feita pelo(a) enfermeiro(a), bem como de determinantes e desfechos de implementação na prática clínica da Atenção Primária à Saúde. Seus resultados são importantes para expandir essa assistência em locais onde a consulta de enfermagem para pessoas com diabetes é ausente, dificultada ou restrita. Estudo registrado na plataforma ReBEC. Objetivo 2 Método efetividadeimplementação, efetividadeimplementação implementação, efetividade-implementação 19 insulinoterapia Campinas 11 1: controle habituais osas as os(as enfermeirosas enfermeiros enfermeiros(as ADCES SelfCare Self Care Behaviors Behaviors™ múltiplos Capacidade Oportunidade COMB, COMB COM B , (COM-B) viabilidade adequação esperados peloa pelo pelo(a enfermeiroa, enfermeiroa enfermeiro enfermeiro(a) ausente restrita ReBEC (COM-B enfermeiro(a
ABSTRACT Objective: To describe an implementation study protocol for an intervention based on educational guidelines focused on seven self-care behaviors, through phone calls to individuals with type 2 diabetes. Method: We will conduct a hybrid type 1 effectiveness-implementation pragmatic randomized clinical trial, with 198 individuals with type 2 diabetes on insulin therapy, from the Glycemic Self-Monitoring Program of two Primary Health Care in the city of São Paulo and three in Campinas, located in the state of Sao Paulo. Patients will be allocated in a 1:1 ratio to either the intervention or control group. Both groups will receive standard care, with the intervention group also receiving a phone call. During the call, nurses will provide guidance based on seven self-care behaviors, known as The ADCES7 Self-Care Behaviors™. Evaluations will happen at the baseline, and after 3- and 6-months post initiation of the trial. Glycemic levels and adherence to self-care behaviors will be compared before and after the intervention using multiple linear regression models. Through interviews with participants from the intervention group, implementation determinants based on the Capability, Opportunity, Motivation-Behavior (COM-B) model, and implementation outcomes feasibility, acceptability, and appropriateness will be evaluated. Expected outcomes: We will evaluate the effectiveness of an intervention while exploring contextual conditions for its implementation in clinical practice of Primary Health Care. This study will provide preliminary evidence on the effectiveness of educational guidance through nurse-led telephone calls, as well as implementation determinants and outcomes in the clinical practice of Primary Health Care. Its results are important for expanding this assistance in locations where nursing consultation for people with diabetes is absent, hindered, or restricted. Study is registered on the ReBEC platform. Objective selfcare self care Method effectivenessimplementation trial 19 therapy SelfMonitoring Self Monitoring Campinas 11 1: call ADCES SelfCare Behaviors Behaviors™ baseline 3 6months months 6 models Capability Opportunity MotivationBehavior Motivation Behavior COMB COM B (COM-B model feasibility acceptability evaluated nurseled nurse led absent hindered restricted platform
RESUMEN Objetivo: Describir un protocolo de un studio de implementación de una intervención basada en orientaciones educativas centradas em siete comportamientos de autocuidado, através de llamadas telefónicas a personas con diabetes tipo 2. Método: Se llevará a cabo un ensayo clínico aleatorio pragmático híbrido tipo 1 de efectividad-implementación, que involucrá 198 personas con diabetes mellitus tipo 2 en terapia con insulina, del Programa de Automonitorización Glucémica de dos Unidades Básicas de Salud de la ciudad de São Paulo y tres de Campinas, ubicadas en el estado de São Paulo. Los pacientes se asignarán en una proporción de 1:1 al grupo de intervención o control. Ambos grupos recibirán atención habitual, y el grupo de intervención también recibirá una llamada telefónica. Durante la llamada, los(as) enfermeiros(as) proporcionarán orientación basada en siete comportamientos de autocuidado conocidos como The ADCES7 Self-Care Behaviors™. Las evaluaciones se realizarán al inicio y después de 3 y 6 meses desde el inicio del ensayo. Los niveles de glucemia y la adherencia a los comportamientos de autocuidado se compararán antes y después de la intervención mediante modelos de regresión lineal múltiple. A través de entrevistas con los participantes del grupo de intervención, se evaluarán los determinantes de implementación basados en el modelo de Capacidad, Oportunidad, Motivación-Cambio de Comportamiento (COM-B), y los resultados de implementación viabilidad, aceptabilidad y adecuación. Resultados esperados: Este estudio proporcionará evidencia preliminar sobre la efectividad de la orientación educativa a través de llamadas telefónicas lideradas por enfermeiros(as), así como los determinantes y resultados de implementación en la práctica clínica de la Atención Primaria de Salud. Sus resultados son importantes para expandir esta asistencia en lugares donde la consulta de enfermería para personas con diabetes está ausente, dificultada, o restringida. Estudio registrado en la plataforma ReBEC. Objetivo Método efectividadimplementación, efectividadimplementación implementación, efectividad-implementación 19 insulina Campinas 11 1: control habitual telefónica losas as los(as enfermeirosas enfermeiros enfermeiros(as ADCES SelfCare Self Care Behaviors Behaviors™ múltiple Capacidad Oportunidad MotivaciónCambio Motivación Cambio COMB, COMB COM B , (COM-B) viabilidad adecuación esperados enfermeirosas, ausente dificultada restringida ReBEC (COM-B
4.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
; Lucena, Carlos A.S. de
; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
; Dias, Cristina de O.
; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
; Toledo, Daniela G.P. de
; Takiya, Daniela M.
; Fernandes, Daniell R.R.
; Ament, Danilo C.
; Cordeiro, Danilo P.
; Silva, Darliane E.
; Pollock, Darren A.
; Muniz, David B.
; Gibson, David I.
; Nogueira, David S.
; Marques, Dayse W.A.
; Lucatelli, Débora
; Garcia, Deivys M.A.
; Baêta, Délio
; Ferreira, Denise N.M.
; Rueda-Ramírez, Diana
; Fachin, Diego A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Pádua, Diego G. de
; Barbosa, Diego N.
; Dolibaina, Diego R.
; Amaral, Diogo C.
; Chandler, Donald S.
; Maccagnan, Douglas H.B.
; Caron, Edilson
; Carvalho, Edrielly
; Adriano, Edson A.
; Abreu Júnior, Edson F. de
; Pereira, Edson H.L.
; Viegas, Eduarda F.G.
; Carneiro, Eduardo
; Colley, Eduardo
; Eizirik, Eduardo
; Santos, Eduardo F. dos
; Shimbori, Eduardo M.
; Suárez-Morales, Eduardo
; Arruda, Eliane P. de
; Chiquito, Elisandra A.
; Lima, Élison F.B.
; Castro, Elizeu B. de
; Orlandin, Elton
; Nascimento, Elynton A. do
; Razzolini, Emanuel
; Gama, Emanuel R.R.
; Araujo, Enilma M. de
; Nishiyama, Eric Y.
; Spiessberger, Erich L.
; Santos, Érika C.L. dos
; Contreras, Eugenia F.
; Galati, Eunice A.B.
; Oliveira Junior, Evaldo C. de
; Gallardo, Fabiana
; Hernandes, Fabio A.
; Lansac-Tôha, Fábio A.
; Pitombo, Fabio B.
; Dario, Fabio Di
; Santos, Fábio L. dos
; Mauro, Fabio
; Nascimento, Fabio O. do
; Olmos, Fabio
; Amaral, Fabio R.
; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
; Schmitz, Hermes J.
; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
; Quintino, Hingrid Y.S.
; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
; Franz, Ismael
; Fernandes, Itanna O.
; Golfetti, Ivan F.
; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
; Narita, João P.
; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
; Fernandes, Jose A.M.
; Pacheco, José F.
; Birindelli, José L.O.
; Rezende, José M.
; Avendaño, Jose M.
; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
; Pujol-Luz, José R.
; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
; Donahue, Julian P.
; Alvim, Juliana
; Almeida, Juliana C.
; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
; Kuabara, Kamila M.D.
; Nascimento, Karine B.
; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
; Miranda, Lucília S.
; Salik, Lucy M.
; Bezerra, Luis E.A.
; Silveira, Luis F.
; Campos, Luiz A.
; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
; Cruz, Luiza S. da
; Sekerka, Lukas
; Barros, Lurdiana D.
; Santos, Luziany Q.
; Skoracki, Maciej
; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
; Araújo, Marcel S. de
; Monné, Marcela L.
; Labruna, Marcelo B.
; Santis, Marcelo D. de
; Duarte, Marcelo
; Knoff, Marcelo
; Nogueira, Marcelo
; Britto, Marcelo R. de
; Melo, Marcelo R.S. de
; Carvalho, Marcelo R. de
; Tavares, Marcelo T.
; Kitahara, Marcelo V.
; Justo, Marcia C.N.
; Botelho, Marcia J.C.
; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
; Oliveira, Marcio L. de
; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
; Loeb, Marina V.
; Cohn-Haft, Mario
; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
; Rocha, Matheus dos S.
; Martins, Maurício L.
; Segura, Melissa O.
; Cardenas, Melissa Q.
; Duarte, Mércia E.
; Ivie, Michael A.
; Mincarone, Michael M.
; Borges, Michela
; Monné, Miguel A.
; Casagrande, Mirna M.
; Fernandez, Monica A.
; Piovesan, Mônica
; Menezes, Naércio A.
; Benaim, Natalia P.
; Reategui, Natália S.
; Pedro, Natan C.
; Pecly, Nathalia H.
; Ferreira Júnior, Nelson
; Silva Júnior, Nelson J. da
; Perioto, Nelson W.
; Hamada, Neusa
; Degallier, Nicolas
; Chao, Ning L.
; Ferla, Noeli J.
; Mielke, Olaf H.H.
; Evangelista, Olivia
; Shibatta, Oscar A.
; Oliveira, Otto M.P.
; Albornoz, Pablo C.L.
; Dellapé, Pablo M.
; Gonçalves, Pablo R.
; Shimabukuro, Paloma H.F.
; Grossi, Paschoal
; Rodrigues, Patrícia E. da S.
; Lima, Patricia O.V.
; Velazco, Paul
; Santos, Paula B. dos
; Araújo, Paula B.
; Silva, Paula K.R.
; Riccardi, Paula R.
; Garcia, Paulo C. de A.
; Passos, Paulo G.H.
; Corgosinho, Paulo H.C.
; Lucinda, Paulo
; Costa, Paulo M.S.
; Alves, Paulo P.
; Roth, Paulo R. de O.
; Coelho, Paulo R.S.
; Duarte, Paulo R.M.
; Carvalho, Pedro F. de
; Gnaspini, Pedro
; Souza-Dias, Pedro G.B.
; Linardi, Pedro M.
; Bartholomay, Pedro R.
; Demite, Peterson R.
; Bulirsch, Petr
; Boll, Piter K.
; Pereira, Rachel M.M.
; Silva, Rafael A.P.F.
; Moura, Rafael B. de
; Boldrini, Rafael
; Silva, Rafaela A. da
; Falaschi, Rafaela L.
; Cordeiro, Ralf T.S.
; Mello, Ramon J.C.L.
; Singer, Randal A.
; Querino, Ranyse B.
; Heleodoro, Raphael A.
; Castilho, Raphael de C.
; Constantino, Reginaldo
; Guedes, Reinaldo C.
; Carrenho, Renan
; Gomes, Renata S.
; Gregorin, Renato
; Machado, Renato J.P.
; Bérnils, Renato S.
; Capellari, Renato S.
; Silva, Ricardo B.
; Kawada, Ricardo
; Dias, Ricardo M.
; Siewert, Ricardo
; Brugnera, Ricaro
; Leschen, Richard A.B.
; Constantin, Robert
; Robbins, Robert
; Pinto, Roberta R.
; Reis, Roberto E. dos
; Ramos, Robson T. da C.
; Cavichioli, Rodney R.
; Barros, Rodolfo C. de
; Caires, Rodrigo A.
; Salvador, Rodrigo B.
; Marques, Rodrigo C.
; Araújo, Rodrigo C.
; Araujo, Rodrigo de O.
; Dios, Rodrigo de V.P.
; Johnsson, Rodrigo
; Feitosa, Rodrigo M.
; Hutchings, Roger W.
; Lara, Rogéria I.R.
; Rossi, Rogério V.
; Gerstmeier, Roland
; Ochoa, Ronald
; Hutchings, Rosa S.G.
; Ale-Rocha, Rosaly
; Rocha, Rosana M. da
; Tidon, Rosana
; Brito, Rosangela
; Pellens, Roseli
; Santos, Sabrina R. dos
; Santos, Sandra D. dos
; Paiva, Sandra V.
; Santos, Sandro
; Oliveira, Sarah S. de
; Costa, Sávio C.
; Gardner, Scott L.
; Leal, Sebastián A. Muñoz
; Aloquio, Sergio
; Bonecker, Sergio L.C.
; Bueno, Sergio L. de S.
; Almeida, Sérgio M. de
; Stampar, Sérgio N.
; Andena, Sérgio R.
; Posso, Sergio R.
; Lima, Sheila P.
; Gadelha, Sian de S.
; Thiengo, Silvana C.
; Cohen, Simone C.
; Brandão, Simone N.
; Rosa, Simone P.
; Ribeiro, Síria L.B.
; Letana, Sócrates D.
; Santos, Sonia B. dos
; Andrade, Sonia C.S.
; Dávila, Stephane
; Vaz, Stéphanie
; Peck, Stewart B.
; Christo, Susete W.
; Cunha, Suzan B.Z.
; Gomes, Suzete R.
; Duarte, Tácio
; Madeira-Ott, Taís
; Marques, Taísa
; Roell, Talita
; Lima, Tarcilla C. de
; Sepulveda, Tatiana A.
; Maria, Tatiana F.
; Ruschel, Tatiana P.
; Rodrigues, Thaiana
; Marinho, Thais A.
; Almeida, Thaís M. de
; Miranda, Thaís P.
; Freitas, Thales R.O.
; Pereira, Thalles P.L.
; Zacca, Thamara
; Pacheco, Thaynara L.
; Martins, Thiago F.
; Alvarenga, Thiago M.
; Carvalho, Thiago R. de
; Polizei, Thiago T.S.
; McElrath, Thomas C.
; Henry, Thomas
; Pikart, Tiago G.
; Porto, Tiago J.
; Krolow, Tiago K.
; Carvalho, Tiago P.
; Lotufo, Tito M. da C.
; Caramaschi, Ulisses
; Pinheiro, Ulisses dos S.
; Pardiñas, Ulyses F.J.
; Maia, Valéria C.
; Tavares, Valeria
; Costa, Valmir A.
; Amaral, Vanessa S. do
; Silva, Vera C.
; Wolff, Vera R. dos S.
; Slobodian, Verônica
; Silva, Vinícius B. da
; Espíndola, Vinicius C.
; Costa-Silva, Vinicius da
; Bertaco, Vinicius de A.
; Padula, Vinícius
; Ferreira, Vinicius S.
; Silva, Vitor C.P. da
; Piacentini, Vítor de Q.
; Sandoval-Gómez, Vivian E.
; Trevine, Vivian
; Sousa, Viviane R.
; Sant’Anna, Vivianne B. de
; Mathis, Wayne N.
; Souza, Wesley de O.
; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
5.
Periodontal diseases and tooth wear in sheep flocks in the State of Goiás, Brazil Goiás
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Martins, Andressa S.
; Silva, Tamires A.
; Athayde, Flávia R.F.
; Saraiva, Júlia R.
; Mendes, Juliana G.
; Cardoso, Maria Vitória S.
; Dutra, Iveraldo S.
; Borsanelli, Ana Carolina
.
RESUMO: As afecções dentárias e periodontais constituem uma preocupação sanitária de grande importância em rebanhos ovinos, uma vez que afetam a saúde e o bem-estar dos animais, e representam uma das principais causas para o abate prematuro. No Brasil, estudos sobre a ocorrência dessas afecções em ovinos são escassos. Assim, o presente estudo teve como objetivo avaliar a prevalência de doenças periodontais e desgaste dentário em rebanhos ovinos no estado de Goiás. Para isso, realizou-se o exame clínico bucal em 325 ovinos em sete propriedades rurais de seis municípios do estado. As lesões periodontais, caracterizadas por recessão gengival em, pelo menos, um dente incisivo, foram observadas em 48,3% (157/325) dos ovinos, enquanto nos mastigatórios ocorreu em 13,2% (43/325) dos ovinos avaliados. O desgaste dentário em dentes mastigatórios foi identificado em 69,2% (255/325) dos ovinos e 10,7% (35/325) dos ovinos apresentaram desgaste dentário em dentes incisivos. Ovinos com idade superior a 36 meses tiveram um aumento na frequência do desgaste dentário. Dos 325 ovinos examinados, 171 (52,62%) apresentaram sinais de sangramento à sondagem, compatíveis com o quadro de gengivite, sendo que 69 (40,36%) apresentaram idade superior a 36 meses. Dos 325 ovinos avaliados, 38 (11,69%) apresentaram gengivite em todos os dentes, dos quais 21 (55,26%) apresentaram idade superior a 36 meses. Pela análise de regressão logística, foi possível observar que a idade mostrou associação com a ocorrência de gengivite. Alterações menos frequentes como a bolsa periodontal e a perda de, pelo menos, um elemento dentário também foram observadas em 4,9% (16/325) e 17,8% (58/325) dos ovinos, respectivamente. Os resultados do presente estudo indicam que a presença doenças periodontais e desgaste dentário é uma ocorrência comum nos rebanhos avaliados. Portanto, enfatiza-se a necessidade de incluir a saúde bucal dos ovinos na rotina da propriedade como uma medida preventiva essencial para melhorar a qualidade de vida e o bem-estar dos animais, bem como os índices zootécnicos. RESUMO bemestar estar animais prematuro Brasil escassos Assim Goiás isso realizouse realizou se 32 incisivo 483 48 3 48,3 157/325 157325 157 (157/325 132 13 2 13,2 43/325 43325 43 (43/325 avaliados 692 69,2 255/325 255325 255 (255/325 107 10 7 10,7 35/325 35325 35 (35/325 incisivos examinados 17 52,62% 5262 52 62 (52,62% sondagem 6 40,36% 4036 40 (40,36% 11,69% 1169 11 (11,69% 55,26% 5526 55 26 (55,26% logística 49 4 9 4,9 16/325 16325 16 (16/325 178 8 17,8 58/325 58325 58 (58/325 respectivamente Portanto enfatizase enfatiza zootécnicos 48, 157/32 15732 15 (157/32 1 13, 43/32 4332 (43/32 69, 255/32 25532 25 (255/32 10, 35/32 3532 (35/32 52,62 526 5 (52,62 40,36 403 (40,36 11,69 116 (11,69 55,26 552 (55,26 4, 16/32 1632 (16/32 17, 58/32 5832 (58/32 157/3 1573 (157/3 43/3 433 (43/3 255/3 2553 (255/3 35/3 353 (35/3 52,6 (52,6 40,3 (40,3 11,6 (11,6 55,2 (55,2 16/3 163 (16/3 58/3 583 (58/3 157/ (157/ 43/ (43/ 255/ (255/ 35/ (35/ 52, (52, 40, (40, 11, (11, 55, (55, 16/ (16/ 58/ (58/ (157 (43 (255 (35 (52 (40 (11 (55 (16 (58 (15 (4 (25 (3 (5 (1 ( (2
ABSTRACT: Dental and periodontal affections consist of health concerns of great importance in sheep flocks, as they affect the health and welfare of animals and represent one of the main causes of premature slaughter. Studies on the occurrence of these conditions in sheep are scarce in Brazil. The present study aimed to evaluate the prevalence of periodontal diseases and tooth wear in sheep flocks in the State of Goiás. For this, a clinical oral examination was conducted on 325 sheep from seven farms in six municipalities of the State. Periodontal lesions, characterized by gingival recession in at least one incisor tooth, were observed in 48.3% (157/325) of the sheep, while in cheek teeth it occurred in 13.2% (43/325) of the evaluated sheep. Dental wear on cheek teeth was identified in 69.2% (255/325) of the sheep, and 10.7% (35/325) of the ovines showed dental wear on incisor teeth. Sheep older than 36 months had an increase in the frequency of tooth wear. A total of 171 (52.62%) out of the 325 examined sheep had signs of bleeding on probing, which is compatible with gingivitis, and 69 (40.36%) were older than 36 months. Thirty-eight (11.69%) out of the 325 evaluated ovines had gingivitis in all teeth, among which 21 (55.26%) were older than 36 months. Logistic regression analysis allowed the observation that age was associated with the occurrence of gingivitis. Less frequent changes such as periodontal pockets and loss of at least one tooth were also observed in 4.9% (16/325) and 17.8% (58/325) of the sheep, respectively. It indicates that the presence of periodontal diseases and tooth wear is a common occurrence in the evaluated flocks. Therefore, there is a need to include the oral health of sheep in the routine of the farm as an essential preventive measure to improve the quality of life, animal welfare, and zootechnical indices. ABSTRACT slaughter Brazil Goiás this 32 lesions 483 48 3 48.3 157/325 157325 157 (157/325 132 13 2 13.2 43/325 43325 43 (43/325 692 69.2 255/325 255325 255 (255/325 107 10 7 10.7 35/325 35325 35 (35/325 17 52.62% 5262 52 62 (52.62% probing 6 40.36% 4036 40 (40.36% Thirtyeight Thirty eight 11.69% 1169 11 (11.69% 55.26% 5526 55 26 (55.26% 49 4 9 4.9 16/325 16325 16 (16/325 178 8 17.8 58/325 58325 58 (58/325 respectively Therefore life indices 48. 157/32 15732 15 (157/32 1 13. 43/32 4332 (43/32 69. 255/32 25532 25 (255/32 10. 35/32 3532 (35/32 52.62 526 5 (52.62 40.36 403 (40.36 11.69 116 (11.69 55.26 552 (55.26 4. 16/32 1632 (16/32 17. 58/32 5832 (58/32 157/3 1573 (157/3 43/3 433 (43/3 255/3 2553 (255/3 35/3 353 (35/3 52.6 (52.6 40.3 (40.3 11.6 (11.6 55.2 (55.2 16/3 163 (16/3 58/3 583 (58/3 157/ (157/ 43/ (43/ 255/ (255/ 35/ (35/ 52. (52. 40. (40. 11. (11. 55. (55. 16/ (16/ 58/ (58/ (157 (43 (255 (35 (52 (40 (11 (55 (16 (58 (15 (4 (25 (3 (5 (1 ( (2
6.
Brain-derived neurotrophic factor serum levels following ketamine and esketamine intervention for treatment-resistant depression: secondary analysis from a randomized trial Brainderived Brain derived treatmentresistant treatment resistant depression
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Caliman-Fontes, Ana Teresa
; Leal, Gustavo C.
; Correia-Melo, Fernanda S.
; Paixao, Camilla S.
; Carvalho, Michelle S.
; Jesus-Nunes, Ana Paula
; Vieira, Flavia
; Magnavita, Guilherme
; Bandeira, Igor D.
; Mello, Rodrigo P.
; Beanes, Graziele
; Silva, Samantha S.
; Echegaray, Mariana
; Carvalho, Lucas P.
; Machado, Paulo
; Sampaio, Aline S.
; Cardoso, Taiane de A.
; Kapczinski, Flávio
; Lacerda, Acioly L. T.
; Quarantini, Lucas C.
.
Abstract Objectives Evidence suggests that ketamine’s influence on brain-derived neurotrophic factor (BDNF) might be involved in its mechanism of rapid antidepressant action. We aimed to evaluate the differential impact of ketamine and esketamine on serum BDNF levels and its association with response patterns in treatment-resistant depression (TRD). Methods Participants (n = 53) are from a randomized, double-blind clinical trial comparing the efficacy of single-dose ketamine (0.5mg/kg, n = 27) and esketamine (0.25mg/kg, n = 26) in TRD. Depression severity was assessed before and 24 hours, 72 hours, and 7 days after the intervention, using the Montgomery-Åsberg Depression Rating Scale (MADRS). Blood samples were collected before infusion, 24 hours, and 7 days afterwards. Results There were no significant changes in BDNF levels at post-infusion evaluation points, and no difference in BDNF levels comparing ketamine and esketamine. Both drugs exhibited similar therapeutic effect. There was no association between BDNF levels and response to treatment or severity of depressive symptoms. Conclusion There was no significant treatment impact on BDNF serum levels – neither with ketamine nor esketamine – despite therapeutic response. These results suggest that ketamine or esketamine intervention for TRD has no impact on BDNF levels measured at 24 hours and 7 days after the infusion. This clinical trial is registered on the Japan Primary Registries Network: UMIN000032355. ketamines s brainderived brain derived (BDNF action treatmentresistant resistant . (TRD) 53 randomized doubleblind double blind singledose single dose 0.5mg/kg, 05mgkg mgkg 0 5mg kg mg (0.5mg/kg 27 0.25mg/kg, 025mgkg 25mg (0.25mg/kg 26 2 MontgomeryÅsberg Montgomery Åsberg MADRS. MADRS (MADRS) infusion afterwards postinfusion post points effect symptoms Network UMIN000032355 UMIN (TRD 5 0.5mg/kg 0.25mg/kg (MADRS UMIN00003235 UMIN0000323 UMIN000032 UMIN00003 UMIN0000 UMIN000 UMIN00 UMIN0
7.
Aging-related predictive factors for oxygenation improvement and mortality in COVID-19 and acute respiratory distress syndrome (ARDS) patients exposed to prone position: A multicenter cohort study Agingrelated Aging related COVID19 COVID 19 COVID-1 ARDS (ARDS position COVID1 1 COVID-
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Cunha, Marieta C.A.
; Schardong, Jociane
; Righi, Natiele C.
; Lunardi, Adriana C.
; Sant’Anna, Guadalupe N.
; Isensee, Larissa P.
; Xavier, Rafaela F.
; Pompeu, Jose E.
; Weigert, Renata M.
; Matte, Darlan L.
; Cardoso, Rozana A.
; Abras, Ana C.V.
; Silva, Antonio M.V.
; Dorneles, Camila C.
; Werle, Roberta W.
; Starke, Ana C.
; Ferreira, Juliana C.
; Plentz, Rodrigo D.M.
; Carvalho, Celso R.F.
.
Abstract Background: Elderly patients are more susceptible to Coronavirus Disease-2019 (COVID-19) and are more likely to develop it in severe forms, (e.g., Acute Respiratory Distress Syndrome [ARDS]). Prone positioning is a treatment strategy for severe ARDS; however, its response in the elderly population remains poorly understood. The main objective was to evaluate the predictive response and mortality of elderly patients exposed to prone positioning due to ARDS-COVID-19. Methods: This retrospective multicenter cohort study involved 223 patients aged ≥ 65 years, who received prone position sessions for severe ARDS due to COVID-19, using invasive mechanical ventilation. The PaO2/FiO2 ratio was used to assess the oxygenation response. The 20-point improvement in PaO2/FiO2 after the first prone session was considered for good response. Data were collected from electronic medical records, including demographic data, laboratory/image exams, complications, comorbidities, SAPS III and SOFA scores, use of anticoagulants and vasopressors, ventilator settings, and respiratory system mechanics. Mortality was defined as deaths that occurred until hospital discharge. Results: Most patients were male, with arterial hypertension and diabetes mellitus as the most prevalent comorbidities. The non-responders group had higher SAPS III and SOFA scores, and a higher incidence of complications. There was no difference in mortality rate. A lower SAPS III score was a predictor of oxygenation response, and the male sex was a risk predictor of mortality. Conclusion: The present study suggests the oxygenation response to prone positioning in elderly patients with severe COVID-19-ARDS correlates with the SAPS III score. Furthermore, the male sex is a risk predictor of mortality. Background Disease2019 Disease 2019 Disease-201 COVID19 COVID 19 (COVID-19 forms e.g., eg e g (e.g. ARDS. . [ARDS]) however understood ARDSCOVID19. ARDSCOVID19 ARDSCOVID 19. ARDS-COVID-19 Methods 22 6 years COVID19, 19, COVID-19 ventilation PaO2FiO2 PaOFiO PaO2 FiO2 PaO FiO PaO2/FiO 20point point 20 records data laboratoryimage laboratory image exams complications comorbidities scores vasopressors settings mechanics discharge Results nonresponders non responders rate Conclusion COVID19ARDS COVIDARDS Furthermore Disease201 201 Disease-20 COVID1 1 (COVID-1 e.g. (e.g [ARDS] ARDSCOVID1 ARDS-COVID-1 2 COVID-1 PaO2FiO Disease20 Disease-2 (COVID- e.g [ARDS ARDS-COVID- COVID- Disease2 Disease- (COVID ARDS-COVID
8.
Levels of energy supplementation for heifers in Tifton 85 pasture on carcass characteristics, internal organs and meat quality 8 characteristics
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SILVA, MARCELO A. DA
; ALVES FILHO, DARI C.
; MACHADO, DIEGO S.
; MARTINI, ANA PAULA M.
; CARDOSO, GILMAR S.
; BRONDANI, IVAN LUIZ
; COCCO, JOZIANE M.
; CATTELAM, PATRÍCIA M.M.
.
Abstract The objective of this study was to evaluate the effect of different levels of concentrate supplementation on carcass characteristics of heifers finished on Tifton 85 pasture. Thirty-two cross-breed heifers (Charolais and Nellore) on average aged 25.51 months and weighing 298 kg were used in a completely randomized experiment. The animals were distributed uniformly to receive four different levels of concentrates based on the body weight: 0.0; 0.4; 0.8 and 1.2%. Animals were slaughtered at 29 months of age. There was increasing linear effect of levels energy supplementation on: slaughter weight, hot and cold carcass weights,hot and cold dressing percentage, thigh thickness, carcass compactness, and L* and b* color values. It was observed quadratic effect of levels of energy supplementation on the percentage of fat in the carcass. Different levels of energy supplementation did not modify the accumulation of vital organs and visceral fat or the sensory attributes of the meat. Higher levels of energy supplementation promote increases in carcass traits of heifers when finished on Tifton 85 pasture. 8 pasture Thirtytwo Thirty two crossbreed cross breed Charolais Nellore 2551 25 51 25.5 experiment weight 0.0 00 0 0.4 04 4 08 0. 12 1 2 1.2% age weightshot weights thickness compactness L b values meat 255 5 25. 1.2 1.
9.
Ciência da disseminação e implementação em países de língua portuguesa: por que considerar? portuguesa considerar
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Sala, Danila Cristina Paquier
; Okuno, Meiry Fernanda Pinto
; Buccini, Gabriela
; Hankins, Jane Silva
; Câmara, Alice Barros
; Vieira, Ana Claudia
; Horta, Ana Lucia de Moraes
; Varela, Andrea Liliana Vesga
; Trapé, Carla Andrea
; Treichel, Carlos Alberto dos Santos
; Luizaga, Carolina Terra de Moraes
; Oliveira, Cintia de Freitas
; Luquine Jr, Cézar D
; Bonfim, Daiana
; Melo, Daiane Sousa
; Fatori, Daniel
; Bernardo, Debora
; Silva, Flávio Dias
; Paiva Neto, Francisco Timbó de
; Sousa, Girliani Silva de
; Relvas, Gláubia Rocha Barbosa
; Eshriqui, Ilana
; Chavez, Leidy Janeth Erazo
; Almeida, Leticia Yamawaka de
; Godoi, Lídia Pereira da Silva
; Belotti, Lorrayne
; Corrêa, Lucas Hernandes
; Cordeiro, Luciana
; Hespanhol, Luiz
; Juskevicius, Luize Fábrega
; Padoveze, Maria Clara
; Bueno, Mariana
; Siqueira, Marina Martins
; Bortoli, Maritsa Carla de
; Louvison, Marília Cristina Prado
; Cardoso, Marília Mastrocolla de Almeida
; Becker, Natália
; Tanaka, Oswaldo Yoshimi
; Costa, Paula Cristina Pereira da
; Bomfim, Rafael Aiello
; Luz, Reginaldo Adalberto
; Gimbel, Sarah
; Dias, Sónia
; Castral, Thaíla Corrêa
; Domingos, Thiago da Silva
; Baumann, Ana A.
.
10.
Autochthonous endophytic bacteria from Musa sp. controls Fusarium oxysporum f. sp. cubense under in vitro conditions
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MARTINS, MARIA J.
; XAVIER, ADELICA A.
; CARDOSO, ISABELLE C.
; SILVEIRA, DANIELA F.
; RIBEIRO, REGINA C.F.
; PIMENTA, SAMY
; NIETSCHE, SILVIA
.
Abstract Fusarium wilt caused by Fusarium oxysporum f. sp. cubense (foc) is one of the main diseases affecting banana crops. Biological control emerges as an alternative technology to prevent the spread of the disease. The objective of this work was to evaluate the effects of endophytic bacteria isolated from banana Prata Anã challenged with the foc in pairing and volatile tests under in vitro conditions. Forty endophytic isolates of the genera Bacillus, Klebsiella, Paenibacillus, Stenotrophomonas, Lysinibacillus and Sporolactobacillus isolated from banana roots were challenged with foc. The principal component analysis showed that the spore germination variable in the presence of bacterial cells explained better the variance (29.88%). Spore germination in the presence of bacterial cells, number of spores/cm2 in paired and volatile tests, and colony area in volatile tests explained about 86.10% of the total variance observed. The isolate EB37 (Bacillus sp., JN215502.1) reduced 96% of the germination of Fusarium oxysporum f. sp. cubense spores. The UPMGA clustering method based on Euclidean distance divides the 40 endophytic bacteria isolates into eight groups. The autochthonous bacteria isolated from Musa sp. of the genera Bacillus, Lysinibacillus, Stenotrophomonas, Sporolactobacillus and Paenibacillus showed promising results in foc control under in vitro conditions.
11.
Correlations between Web Searches and COVID-19 Epidemiological Indicators in Brazil
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Locatelli, Marcelo Sartori
; Cunha, Evandro L. T. P
; Guiginski, Janaína
; Franco, Ramon A. S
; Bernardes, Tereza
; Alzamora, Pedro Loures
; Silva, Daniel Victor F. da
; Ganem, Marcelo Augusto S
; Santos, Thiago H. M
; Carvalho, Anne I. R
; Souza, Leandro M. V
; Paixão, Gabriela P. F
; Chaves, Elisa França
; Santos, Guilherme Bezerra dos
; Santos, Rafael Vinícius dos
; Freitas, Amanda Cupertino de
; Flores, Matheus G
; Biezuner, Rachel F
; Cardoso, Rodolfo Lins
; Fonseca, Rodrigo Machado
; Silva, Ana Paula Couto da
; Meira Jr, Wagner
.
Abstract: COVID-19 rapidly spread across the world in an unprecedented outbreak with a massive number of infected and fatalities. The pandemic was heavily discussed and searched on the internet, which generated big amounts of data related to it. This led to the possibility of attempting to forecast coronavirus indicators using the internet data. For this study, Google Trends statistics for 124 selected search terms related to pandemic were used in an attempt to find which keywords had the best Spearman correlations with a lag, as well as a forecasting model. It was found that keywords related to coronavirus testing among some others, such as “I have contracted covid”, had high correlations (≥0.7) with few weeks of lag (≤4 weeks). Besides that, the ARIMAX model using those keywords had promising results in predicting the increase or decrease of epidemiological indicators, although it was not able to predict their exact values. Thus, we found that Google Trends data may be useful for predicting outbreaks of coronavirus a few weeks before they happen, and may be used as an auxiliary tool in monitoring and forecasting the disease in Brazil.
12.
Genetic parameters and selection of biofortified lettuce genotypes based on selection indices
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Sousa, Luciana A. de
; Maciel, Gabriel M.
; Juliatti, Fernando C.
; Beloti, Igor F.
; Cardoso, Daniel B. O.
; Siquieroli, Ana C. S.
.
Revista Brasileira de Engenharia Agrícola e Ambiental
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RESUMO A obtenção de vegetais biofortificados, com destaque para a alface, é uma ferramenta para melhorar o estado nutricional da população. Os índices de seleção podem maximizar a seleção simultânea de boas características agronômicas e altos níveis de carotenoides. O objetivo deste estudo foi estimar os parâmetros genéticos e a eficiência de diferentes índices para a seleção de genótipos de alface biofortificados combinados com características agronômicas adequadas. As análises estatísticas foram realizadas com 91 genótipos pertencentes ao banco de germoplasma de alface biofortificada da Universidade Federal de Uberlândia. As variáveis analisadas foram: índice de clorofila das folhas, diâmetro da planta, diâmetro do caule e número de folhas por planta. Os valores encontrados para herdabilidade no sentido restrito (h²) variaram de 89,63% (diâmetro do caule) a 96,05% (clorofila), apresentando alta magnitude. O índice de Smith-Hazel, a soma de “ranks” de Mulamba & Mock, a seleção direta e indireta e o índice base de Williams foram usados para prever os ganhos de seleção. No total, 17 indivíduos foram selecionados usando as metodologias de seleção. Os índices de Smith-Hazel, Williams e Mulamba & Mock são eficientes em mostrar bons ganhos diretos para as características avaliadas. Treze genótipos foram selecionados por todos os índices apresentando características agronômicas favoráveis, sendo promissores para o avanço de geração no programa de melhoramento para obter linhagens de alface biofortificadas.
ABSTRACT Obtaining biofortified vegetables with an emphasis on lettuce is a tool to improve the nutritional status of the population. Selection indices can maximize the simultaneous selection of good agronomic traits and high carotenoid levels. The objective of this study was to estimate the genetic parameters and efficiency of different indices in selecting genotypes of biofortified lettuce with high concentrations of carotenoids and favorable agronomic traits. Statistical analyses were performed on 91 genotypes belonging to the vegetable germplasm bank of the Federal University of Uberlândia, Brazil. The variables analyzed were the chlorophyll index of the leaves, plant diameter, stem diameter, and number of leaves per plant. The values found for narrow sense heritability (h²) ranged from 89.63% (stem diameter) to 96.05% (chlorophyll), showing a high magnitude. The Smith-Hazel index, sum of ranks by the Mulamba & Mock index, direct and indirect selection, and Williams base index were used to predict the selection gains. A total of 17 individuals were selected using the selection methodologies. The Smith-Hazel, Williams, and Mulamba & Mock indices were efficient in showing good direct gains for the evaluated traits. Thirteen genotypes were selected for all indices presenting suitable agronomic traits, which show promise for advancing generations within the breeding program to obtain biofortified lettuce strains.
13.
Toxicological, biochemical and morphophysiological effects of Serjania erecta leaf aqueous extract on Piaractus mesopotamicus
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VENTURA, ARLENE S.
; CORRÊA FILHO, RUY A.C.
; SPICA, LOUISE N.
; SILVA, ANA CREMILDA F.
; ARAÚJO, ANDREA M. DE
; CARDOSO, CLAUDIA A.L.
; JERÔNIMO, GABRIELA T.
; POVH, JAYME A.
.
Abstract This study was carried out to determine the toxicity and biochemical and morphophysiological changes caused by Serjania erecta leaf aqueous extract in pacu (Piaractus mesopotamicus). For acute toxicity testing (CL50-4h), pacu juveniles were exposed during 4 h to Serjania erecta aqueous extract concentrations of 2.5, 12.5, 25, 50, 100, and 150 µg mL-1, which were added directly to the water in the tanks. In the control group, the animals were kept in water free from aqueous extract. CL50-4 h was estimated at 57.43 µg mL-1. After exposure to the aqueous extract, the highest (P<0.05) glucose concentration and the lowest (P<0.05) plasma sodium level were when the fish were exposed to the S. erecta concentration of 50 µg mL-1. Mortality occurred at S. erecta extract levels higher than 50 μg mL-1, and all fish died at concentrations greater than 100 μg mL-1. In addition, exposure to this extract caused severe histological changes in the gills and liver with higher prevalence of necrosis (30.2%), and fatty degeneration (77.4%) respectively. At the concentrations tested here, S. erecta aqueous extract causes morphofunctional alterations in this fish species.
https://doi.org/10.1590/0001-3765202120190479
57 downloads
14.
Antimicrobial properties of heterocyclic compounds against clinical mastitis isolates
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Acosta, Atzel C.
; Cardoso, Marcos V.O.
; Oliveira Filho, Gevanio B.
; Pinheiro Junior, José W.
; Leite, Ana Cristina L.
; Mota, Rinaldo A.
.
RESUMO: A mastite causa significativas perdas econômicas à indústria leiteira bovina. O presente estudo teve como objetivo avaliar as propriedades antibacterianas de 39 derivados heterocíclicos (1,3-tiazóis e 4-tiazolidinonas) contra isolados clínicos de mastite em vacas leiteiras. Amostras de leite foram coletadas de vacas com mastite clínica e as espécies bacterianas isoladas foram identificadas por PCR. A atividade antibacteriana foi avaliada pelo método de microdiluição em caldo. Primeiramente, os 39 compostos heterocíclicos foram testados contra quatro isolados bacterianos (Staphylococcus aureus, Streptococcus agalactiae, Corynebacterium bovis e Escherichia coli) escolhidos aleatoriamente dentre os recuperados das amostras de leite (Estudo 1). Posteriormente, compostos com atividade antibacteriana mais forte foram testados contra todos os isolados bacterianos recuperados das amostras de leite (Estudo 2). Os compostos 1,3-tiazóis apresentaram a maior atividade antibacteriana, principalmente os compostos 30 e 38, que também apresentaram propriedades bactericidas de acordo com seus valores de concentração inibitória mínima (CIM) e concentração bactericida mínima (CBM). Os isolados Corynebacterium spp. e Enterobacteriaceae foram os mais suscetíveis aos compostos 30 e 38. Os compostos 30 e 38 mostraram-se promissores como novos agentes antimicrobianos.
ABSTRACT: Mastitis causes significant economic losses to the dairy cattle industry. The present study aimed to evaluate the antibacterial properties of 39 heterocyclic derivatives (1,3-thiazoles and 4-thiazolidinones) against clinical mastitis isolates from dairy cows. Milk samples were collected from cows with clinical mastitis and the bacterial species were identified by PCR. Antibacterial activity was assessed using the broth microdilution method. First, 39 heterocyclic compounds were tested against four bacterial isolates (Staphylococcus aureus, Streptococcus agalactiae, Corynebacterium bovis and Escherichia coli) randomly chosen from those recovered from the milk samples (Study 1). Subsequently, the compounds with the strongest antibacterial activity were tested against all the bacterial isolates recovered from the milk samples (Study 2). 1,3-thiazoles showed the strongest antibacterial activity, specially compounds 30 and 38, which also showed bactericidal properties according to their minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values. Corynebacterium spp. and Enterobacteriaceae isolates were the most susceptible to compounds 30 and 38. Compounds 30 and 38 are promising targets for new antimicrobial agents.
https://doi.org/10.1590/1678-5150-pvb-6862
26 downloads
15.
Diabetes influences liver stiffness in chronic hepatitis C patients with and without virological cure: A longitudinal study
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Pontual, Daniela Malta
; Nabuco, Leticia Cancella
; Luiz, Ronir Raggio
; Cardoso, Ana Carolina
; Perez, Renata M.
; Villela-Nogueira, Cristiane A.
.
OBJECTIVES: The aim was to prospectively assess the variation in liver stiffness (LS) and the associated factors for LS progression in a cohort of naïve, non-responder (NR), and sustained virological response (SVR) chronic hepatitis C (CHC) patients. METHODS: This was a longitudinal study on CHC patients prospectively followed with serial elastography (Fibroscan®). The LS progression rate was determined, and the associated factors for progression were assessed using multiple linear regression analysis. RESULTS: A total of 406 patients were followed up for 44 (35-53) months [naïve (29%), NR (24%), and SVR (47%)]. At the end of the follow-up period, the SVR group had a significant decrease in LS [11.8 (9.2) vs. 8.8 (8.4) kPa (p<0.001)], the NR group had a significant increase in LS [6.6 (5.2) vs. 7.1 (4.5) kPa (p=0.069)], and the naïve group had no change in LS [6.3 (3.0) vs. 6.0 (3.8) kPa (p=0.22)]. The related factors for LS progression were lack of SVR (p=0.002) and diabetes (p=0.05). In the non-diabetic SVR group, a negative rate of progression (-0.047 kPa/month) was observed, whereas in the diabetic SVR group, a positive rate of progression (+0.037 kPa/month) was observed. The highest rate of progression was observed in NR with diabetes at the rate of +0.044 kPa/month. CONCLUSION: LS in diabetes patients progresses despite SVR, suggesting the need for a close follow-up of this group post-treatment considering the risk of progression of liver disease even after SVR.
https://doi.org/10.6061/clinics/2021/e3236
48 downloads
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