Abstract: This research examines the incorporation of CuO and TiO2 nanoparticles into polypropylene or cotton fabrics to develop reusable personal protective equipment. Different preparation methods are applied to anchor the nanoparticles and avoid leaching. The composition and preparation of fabrics are verified by scanning electron microscopy and X-ray diffraction. Optical properties are assessed by diffuse reflectance spectroscopy and photoluminescence. The results show that for a low ratio of CuO to TiO2, the optical properties improve, reducing bandgap energy and the electron-hole pair recombination rate. Photodegradation of methylene blue increases by 22.8% in polypropylene fabrics and up to 350% in cotton fabrics. In conclusion, photoactivity in polypropylene fabrics is 23.7 times higher than in cotton fabrics, since the preparation method controls the loading of active species.

Resumen: Esta investigación examina la incorporación de nanopartículas de CuO y TiO2 sobre telas de polipropileno o algodón para su implementación como equipo de protección personal reusable. Se utilizan diferentes métodos de preparación para garantizar el anclaje de las nanopartículas y evitar su lixiviación. La composición y preparación de los textiles se verifica por microscopía electrónica de barrido y difracción de rayos X. Las propiedades ópticas se evalúan mediante espectroscopia de reflectancia difusa y fotoluminiscencia. Los resultados muestran que para una baja proporción de CuO a TiO2, se mejoran las propiedades ópticas de los textiles, reduciendo la energía de banda prohibida y la tasa de recombinación del par electrón-hueco. La fotodegradación del azul de metileno aumenta un 22.8% en textiles de polipropileno y hasta 350% en textiles de algodón. En conclusión, la fotoactividad en textiles de polipropileno es 23.7 veces mayor respecto al algodón, ya que con el método de preparación se controla el contenido de las especies activas.

Resumen Introducción: El cáncer de mama es una enfermedad de importancia mundial, caracterizada por un crecimiento anormal de las células que están en el tejido mamario, causada por distintos factores, los cuales pueden ser genéticos, esporádicos, hereditarios y ambientales. Objetivo: Analizar cómo se relacionan los diferentes factores con vigencia y no vigencia de la mamografía en mujeres chilenas dentro del rango etario entre 50 a 69 años, en el año 2023. Método: Estudio observacional, analítico y descriptivo. De esta forma, se analizaron dos grupos que investigar: las mujeres de 50 a 69 años con mamografía vigente (control) y las mujeres que no la tenían vigente (caso), para poder relacionar diversas variables en relación con ello. El total de la muestra fue de 207 mujeres, 119 controles y 88 casos. Resultados: Según la encuesta, las mujeres mayores de 59 años con una odds ratio de 1 (p < 0,87) no tenían diferencias respecto a la vigencia de su mamografía con las menores de 60 años, no así en las mujeres que no se preocupan por su salud, las cuales tienen cuatro veces más probabilidad de no tener la mamografía vigente (p < 0,81). Por otra parte, las mujeres que no poseían el conocimiento sobre la función de la mamografía poseen siete veces más probabilidad de no tener su mamografía vigente. Conclusiones: Es necesario realizar un abordaje diferenciado en cada uno de los factores, tanto de riesgo como protector, asociado al desarrollo del cáncer de mama.

Abstract Introduction: Breast cancer is a disease of global importance, characterized by abnormal growth of cells in the breast tissue, caused by different factors, which can be genetic, sporadic, hereditary and environmental. Objective: Analyze how the different factors are related to validity and non-validity of mammography in Chilean women within the age range between 50 and 69 years, in the year 2023. Method: Observational, analytical and descriptive study. In this way, the two groups to be investigated were analyzed: women between 50 and 69 years old with a current mammogram (control) and women who did not have it current (case), in order to relate various variables in relation to it. The total sample was 207 women, 119 controls and 88 cases. Results: According to the survey, women over 59 years of age with an odds ratio 1 (p < 0.87) had no differences regarding the validity of their mammography with those under 60 years of age, but not in women who do not worry about their health, which are four times more likely to not have a current mammogram (p < 0.81). On the other hand, women who did not have knowledge about the function of mammography are seven times more likely to not have a current mammogram. Conclusions: It is necessary to carry out a differentiated approach to each of the factors, both risk and protective, associated with the development of breast cancer.

ABSTRACT Purpose: This video aims to present an in-depth, step-by-step tutorial on microsurgical reconstruction for obstructive azoospermia, featuring a distinctive case involving anastomosis from vas deferens to rete testis. The primary aim of this endeavor is to offer thorough and practical insights for healthcare professionals and researchers within the realm of reproductive medicine. The video endeavors to disseminate expertise, methodologies, and perspectives that can be advantageous to individuals grappling with obstructive azoospermia, providing a significant contribution to the progress of reproductive medicine and the augmentation of existing treatment alternatives. Materials and Methods: Surgical footage was recorded using the ORBEYE 4K 3D Orbital Camera System by Olympus America, with patient consent acquired for research purposes. Additionally, a retrospective examination of patient records was undertaken to compile relevant medical histories. Results: This video furnishes an exhaustive guide to microsurgical reconstruction for obstructive azoospermia, encompassing a distinctive instance of anastomosis from vas deferens to rete testis. State-of-the-art technology, such as the ORBEYE 4K 3D Orbital Camera, heightens procedural transparency, accentuating the significance of advanced instrumentation. The ethical underpinning is emphasized by obtaining patient consent for footage utilization, and a retrospective chart review augments the repository of valuable patient data. This comprehensive approach serves as an invaluable reservoir of knowledge for medical professionals and underscores excellence in clinical and ethical healthcare research. Conclusions: Anastomosis from vas deferens to rete testis emerges as a viable surgical reconstruction alternative for obstructive azoospermia, particularly when confronted with non-dilated tubules within the epididymis. Purpose indepth, indepth depth, depth in-depth stepbystep step azoospermia expertise methodologies alternatives Methods K D America purposes Additionally histories Results Stateoftheart State art technology transparency instrumentation utilization data Conclusions nondilated non dilated epididymis

ABSTRACT Older people present limited independent functioning and greater difficulties in their activities of daily living as they age. Aim: To determine whether indicators of body adiposity and functional fitness are related to adaptive behavior in Chilean elderly women. Methods: A descriptive cross-sectional study was carried out in 162 elderly adult women. Body adiposity (BA) was determined by body mass index (BMI) and fat mass (FM). Functional fitness (FA) was assessed by means of four physical tests: Arm flexibility, 30-second right arm strength endurance (RFBD), 30-second chair stand (up-and-go) test and the agility test (2.44 m). Adaptive behavior (AC) was assessed using a scale called AC Self-Perception of AC for Women (ACAM). Results: There were negative correlations between AC with chronological age, BMI, MG, and Agility (∼ r= -0.27 to -0.45, p<0.05), while the relationship was positive with leg strength, flexibility, and RFBD (∼ r= 0.17 to 0.26, p<0.05). Comparisons of CA and PA between CA categories were small and medium. The effect size between women categorized as low and high CA was medium (∼ 0.31 to -0.46). However, among women categorized with medium and high CA level it was small (∼ 0.07 to -0.30). Conclusion: The study found that, in women aged 65-84 years, AC tends to decrease with age, while body adiposity increases and functional fitness decreases. It is recommended to implement strategies that address these negative effects of aging, such as prevention and management of body adiposity, functional exercise programs, and promotion of a healthy lifestyle.

RESUMEN Las personas mayores presentan un funcionamiento independiente limitado y mayores dificultades en sus actividades de la vida diaria a medida que envejecen. Objetivo: Determinar si los indicadores de adiposidad corporal y la aptitud funcional se relacionan con el comportamiento adaptativo en mujeres chilenas de edad avanzada. Material y métodos: Se efectuó un estudio descriptivo transversal en 162 mujeres adultas de tercera edad. La adiposidad corporal (AC) se determinó por medio del Índice de masa corporal (IMC) y masa grasa (MG). La aptitud funcional (AF) se evaluó por medio de cuatros pruebas físicas: La flexibilidad del brazo, resistencia de fuerza del brazo derecho en 30 segundos (RFBD), prueba de soporte de silla (up-and-go) en 30 segundos y la prueba de agilidad (2,44 m). El comportamiento adaptativo (CA) se evaluó utilizando una escala denominada Auto-percepción del CA para Mujeres (ACAM). Resultados: Hubo correlaciones negativas entre el CA con la edad cronológica, IMC, MG, y Agilidad (∼ r= -0.27 a -0.45, p<0.05), mientras que la relación fue positiva con la fuerza de piernas, flexibilidad, y RFBD (∼ r= 0.17 a 0.26, p<0.05). Las comparaciones de la AC y la AF entre categorías del CA fueron pequeñas y medianas. El tamaño del efecto entre las mujeres categorizadas con bajo y elevado nivel de CA fue medio (∼ 0.31 a -0.46). Sin embargo, entre las mujeres categorizadas con medio y elevado nivel de CA fue pequeño ((∼ 0.07 a -0.30). Conclusión: El estudio encontró que, en mujeres de 65 a 84 años, el CA tiende a disminuir con la edad, mientras que la adiposidad corporal aumenta y la aptitud funcional disminuye. Se recomienda implementar estra-tegias que aborden estos efectos negativos del envejecimiento, como la prevención y manejo de la adiposidad corporal, programas de ejercicios funcionales y la promoción de un estilo de vida saludable.

Abstract Objectives: The aim was to estimate the pubertal growth height of children and adolescents living in a high-altitude region of Peru using the Preece-Baines model 1 (1 PB). Methods: A cross-sectional study was conducted in schoolchildren from the department of Puno (Peru) between 3841 and 3874 masl. The age range was between 4 and 17 years. Standing height was evaluated. 1 PB was used to infer the mathematical and biological parameters of stature. Results: Mathematical parameters estimated by the 1 PB model reflected small residual standard error (RSE) values in both sexes (0.25 in boys and 0.27 in girls). In boys, the age at which peak velocity was reached (APHV) was estimated at 13.21 ± 0.33years. While in girls it was 9.96 ± 0.26years (p < 0.05). In general, girls reached APHV (y) 3.25 years earlier than boys. On the other hand, the growth velocity of maximum height [APHV (cm/y)] of boys was higher (6.33 ± 6.06 cm/y) relative to girls (6.06 ± 0.32 cm/y). Estimated final adult height (EFAH) in boys was reached at 166.020 ± 0.99 cm and height at maximum growth velocity (HPHV) was 153.07 ± 0.67 cm, while in girls they were significantly lower (EFAH; 153.74 ± 0.44 cm and HPHV: 139.73 ± 0.84 cm). Conclusions: This study showed that girls living in Puno at a high altitude in Peru reached APHV 3 years earlier than boys and at the same time reflected slower PHV. These results suggest that pubertal growth at high altitudes is slower in both sexes and especially in girls. Thus, modeling physical growth may be an important step in understanding the onset of puberty at different latitudes. Objectives highaltitude PreeceBaines Preece Baines ( PB. . PB) Methods crosssectional cross sectional (Peru 384 387 masl evaluated stature Results RSE (RSE 0.25 025 0 25 (0.2 027 27 0.2 girls) (APHV 1321 13 21 13.2 033years 33years 0.33years 996 9 96 9.9 026years 26years p 0.05. 005 0.05 05 0.05) general y (y 325 3.2 hand cm/y cmy (cm/y) 6.33 633 6 33 (6.3 606 06 6.0 (6.0 032 32 0.3 cm/y. EFAH (EFAH 166020 166 020 166.02 099 99 0.9 HPHV (HPHV 15307 153 07 153.0 067 67 0.6 15374 74 153.7 044 44 0.4 13973 139 73 139.7 084 84 0.8 cm. cm) Conclusions PHV Thus latitudes 38 02 2 (0. 0. 132 13. 9. 00 0.0 3. (cm/y 6.3 63 (6. 60 6. 03 16602 16 166.0 09 1530 15 153. 1537 7 04 1397 139. 08 8 (0 (6 1660 166.

Abstract Systemic Arterial Hypertension is a multifactorial clinical condition associated with severe outcomes such as stroke and death. One of the main modifiable risk factor for hypertension is an unhealthy diet, often characterized by the consumption of ultraprocessed foods such as sweetened beverages. We aimed to investigate the relationship between the consumption of sweetened beverages, both sugar-sweetened and artificially sweetened, and the prevalence of hypertension in adults. A cross-sectional, household, population-based study with 1,162 adults from two Brazilian cities were carried out. The consumption of food groups and sweetened beverages was obtained by food frequency questionnaire and other data were self-reported. Weight, height, and waist circumference were measured. The association between sweetened beverages consumption and hypertension was analyzed using Poisson regression models, expressed as Prevalence Ratio. The prevalence of hypertension was 16.7%, with no significant difference between genders. The prevalence of consumption of sweetened beverages was 70.3% in men and 54.6% in women, being significantly higher in men. Women who consumed sugar-sweetened and artificially sweetened beverages 6 to 7 days per week had 92% higher prevalence of hypertension compared to those who did not consume or consumed at a lower frequency. Furthermore, women who consumed artificially sweetened beverages at least 1 time per week had 3.36 times higher prevalence of hypertension. The habitual consumption of sweetened beverages may be an important risk factor for hypertension, especially the consumption of diet beverages, which are often marketed as healthier than sugar-sweetened beverages.

Resumen La Hipertensión Arterial Sistémica es una condición clínica multifactorial asociada a resultados graves como el ictus y la muerte. Uno de los principales factores de riesgo modificables de la hipertensión es una dieta poco saludable, a menudo caracterizada por el consumo de alimentos ultraprocesados como las bebidas endulzadas. Nuestro objetivo fue investigar la relación entre el consumo de bebidas endulzadas, tanto azucaradas como edulcoradas artificialmente, y la prevalencia de hipertensión en adultos. Se realizó un estudio transversal, domiciliario y poblacional con 1,162 adultos de dos ciudades brasileñas. El consumo de grupos de alimentos y bebidas endulzadas se obtuvo mediante cuestionario de frecuencia de alimentos y los demás datos fueron autoinformados. Se midieron el peso, la talla y el perímetro de la cintura. La asociación entre el consumo de bebidas endulzadas y la hipertensión se analizó mediante modelos de regresión de Poisson, expresados como Ratio de Prevalencia. La prevalencia de hipertensión fue del 16,7%, sin diferencias significativas entre géneros. La prevalencia de consumo de bebidas endulzadas fue del 70,3% en los hombres y del 54,6% en las mujeres, siendo significativamente mayor en los hombres. Las mujeres que consumían bebidas azucaradas y edulcoradas artificialmente entre 6 y 7 días a la semana tenían 92% mayor prevalencia de hipertensión que las que no consumían o consumían con una frecuencia menor. Además, las mujeres que consumían bebidas edulcoradas al menos 1 vez por semana tenían una prevalencia de hipertensión 3,36 veces mayor. Así pues, el consumo habitual de bebidas endulzadas puede ser un importante factor de riesgo de hipertensión, especialmente el consumo de bebidas dietéticas, que a menudo se comercializan como más saludables que las bebidas azucaradas.

Abstract Objective: To analyze the existing state legislation, including not only the ordinary laws, but also their infralegal regulation and the state legislation on Hospital Dentistry. Material and Methods: A survey was carried out in the databases of the Legislative Assemblies of the Brazilian States and the Federal District, as well as the Regional and Federal Councils of Dentistry in Brazil. Subsequently, a survey was carried out in the databases of the Ministry of Health, State Dental Councils and Federal Dental Council in Brazil. Results: Only 8 Brazilian states have legislation in force regarding hospital dentistry, which represents 29.63% of the federative units. Among the Brazilian regions, the Midwest presented the highest prevalence of the laws found (37.50%), followed by the North (25%) and the other regions with the same coverage (12.50%). Also, an orientation and an ordinance from the Ministry of Health, six resolutions from the Federal Council of Dentistry, and a technical note from the National Health Surveillance Agency were found. Conclusion: Several States do not have rules on the subject, making it imperative to create a federal rule that not only imposes the presence of the dentist, but also regulates the proportion of the team, workload, and availability. Objective Methods District Brazil Subsequently Results dentistry 2963 29 63 29.63 units 37.50%, 3750 37.50% , 37 50 (37.50%) 25% 25 (25% 12.50%. 1250 12.50% . 12 (12.50%) Also Conclusion subject dentist team workload availability 296 2 6 29.6 375 37.50 3 5 (37.50% (25 125 12.50 1 (12.50% 29. 37.5 (37.50 (2 12.5 (12.50 37. (37.5 ( 12. (12.5 (37. (12. (37 (12 (3 (1

RESUMO Objetivo: Comparar as diferenças entre a chord aparente μ e o chord real μ. Métodos: Estudo prospectivo, comparativo, não randomizado e não intervencionista. Os exames de imagem (Pentacam e HD Analyzer) foram realizados na mesma sala e nas mesmas condições escotópicas. Os critérios de inclusão foram idade de 21 a 71 anos; compreensão do termo de consentimento; miopia até 4D e astigmatismo topográfico anterior até 1D. Os critérios de exclusão foram usuários de lentes de contato; pacientes com doenças oculares prévias ou cirurgias; opacidades da córnea; a presença de alterações tomográficas da córnea ou suspeita de ceratocone. Resultados: Em nosso estudo foram analisados 116 olhos de 58 pacientes. A média de idade foi de 30,69 anos (± 7,85). Análises de correlação foram desenvolvidas e o coeficiente de correlação de Pearson (0,647) indica uma relação linear positiva moderada entre as variáveis. A média do chord μ real foi 226,21 ± 128,53 μm e a média do chord μ média foi 278,66 ± 123,90 μm, com diferença média de 52,45 μm (p=0,01). A análise do diâmetro pupilar médio apresentou: 5,76mm no HD Analyzer e 3,31mm no Pentacam. Conclusões: Entendemos a existência de uma diferença significativa entre os métodos e assim a medida de ambos os dispositivos com base em princípios diferentes devemos respeitar suas peculiaridades. Como encontramos correlação entre as duas medidas, acreditamos que ambas podem ser utilizadas na prática diária. Objetivo Métodos prospectivo comparativo intervencionista Pentacam escotópicas 2 7 consentimento D 1D contato cirurgias ceratocone Resultados 11 5 3069 30 69 30,6 ( 7,85. 785 7,85 . 85 7,85) 0,647 0647 0 647 (0,647 variáveis 22621 226 226,2 12853 128 53 128,5 27866 278 66 278,6 12390 123 90 123,9 5245 52 45 52,4 p=0,01. p001 p p=0,01 01 (p=0,01) apresentou 576mm mm 76mm 331mm 3 31mm Conclusões peculiaridades medidas diária 1 306 6 30, 78 7,8 8 0,64 064 64 (0,64 2262 22 226, 1285 12 128, 2786 27 278, 1239 9 123, 524 4 52, p00 p=0,0 (p=0,01 7, 0,6 06 (0,6 p0 p=0, (p=0,0 0, (0, p=0 (p=0, (0 p= (p=0 (p= (p

ABSTRACT Purpose: To compare the differences between the apparent and actual chord μ. Methods: In this prospective, comparative, non-randomized, and non-interventional study, imaging examinations using Pentacam and the HD Analyzer were performed in the same room under the same scotopic conditions. The inclusion criteria were patients aged 21-71 years, able to provide informed consent, myopia up to 4D, and anterior topographic astigmatism up to 1D. Patients using contact lenses, those with previous eye diseases or surgeries, corneal opacities, corneal tomographic changes, or suspected keratoconus were excluded. Results: Altogether, 116 eyes of 58 patients were analyzed. The patients’ mean age was 30.69 (±7.85) years. In the correlation analyses, Pearson’s correlation coefficient of 0.647 indicates a moderate positive linear relationship between apparent and actual chord μ. The mean actual and apparent chord μ were 226.21 ± 128.53 and 278.66 ± 123.90 μm, respectively, with a mean difference of 52.45 μm (p=0.01). The analysis of mean pupillary diameter resulted in 5.76 mm using the HD Analyzer and 3.31 mm using the Pentacam. Conclusions: We found a correlation between the two measurement devices, and even though we found considerable differences, both can be used in daily practice. Given their differences, we should respect their peculiarities as well. Purpose Methods prospective comparative nonrandomized, nonrandomized non randomized, randomized non-randomized noninterventional interventional study conditions 2171 21 71 21-7 years consent 4D D 1D lenses surgeries opacities changes excluded Results Altogether 11 5 analyzed 3069 30 69 30.6 ±7.85 785 7 85 (±7.85 analyses Pearsons Pearson s 0647 0 647 0.64 22621 226 226.2 12853 128 53 128.5 27866 278 66 278.6 12390 123 90 123.9 respectively 5245 52 45 52.4 p=0.01. p001 p p=0.01 . 01 (p=0.01) 576 76 5.7 331 3 31 3.3 Conclusions devices practice well 217 2 21- 1 306 6 30. ±7.8 78 8 (±7.8 064 64 0.6 2262 22 226. 1285 12 128. 2786 27 278. 1239 9 123. 524 4 52. p00 p=0.0 (p=0.01 57 5. 33 3. ±7. (±7. 06 0. p0 p=0. (p=0.0 ±7 (±7 p=0 (p=0. (± p= (p=0 ( (p= (p

RESUMO JUSTIFICATIVA E OBJETIVOS: Os mecanismos subjacentes à dor nociplástica, como a fibromialgia (FM), não são totalmente compreendidos, contudo acredita-se que o processamento sensorial e a modulação da dor alterados desempenham papéis proeminentes para a manutenção da dor nociplástica. Com a hipótese de que alterações no córtex somestésico primário (S1) contribuam para o caráter de dor generalizada da FM, o objetivo deste estudo foi avaliar o envolvimento do córtex somestésico primário em humanos com FM, bem como investigar possíveis associações entre alterações de S1 com sinais e sintomas clínicos da FM. CONTEÚDO: Para esta revisão integrativa, foram utilizadas as seguintes bases de dados: Pubmed e Web of Science, incluindo estudos observacionais realizados em humanos com FM. No total, 541 estudos foram identificados e quatro foram incluídos. A maioria dos estudos são do tipo caso-controle, publicados entre 2016 e 2022. Ao todo, dados de 161 indivíduos foram incluídos. Foi identificado que há alterações morfológicas, hiperativação e aumento da conectividade funcional entre S1 e substância cinzenta periaquedutal e entre S1 e córtex cingulado anterior. CONCLUSÃO: Pacientes com FM apresentam alterações morfológicas e hiperativação em S1, bem como aumento da conectividade funcional entre S1 e substância cinzenta periaquedutal e S1 e sistema límbico. Ademais, diferentes sub-regiões somatotrópicas bilaterais (pernas, tórax, dedos, mãos, face e costas) apresentaram redução da conectividade funcional em pacientes com FM. Essas regiões são frequentemente apresentadas como “tender points” na FM. OBJETIVOS nociplástica , (FM) compreendidos acreditase acredita se S (S1 CONTEÚDO integrativa Science total 54 incluídos casocontrole, casocontrole caso controle, controle caso-controle 201 2022 todo 16 anterior CONCLUSÃO límbico Ademais subregiões sub pernas, pernas (pernas tórax dedos mãos costas tender points (FM (S 5 20 202 1 2

ABSTRACT BACKGROUND AND OBJECTIVES: The mechanisms underlying nociplastic pain, such as fibromyalgia (FM), are not fully understood, however, it is believed that altered sensory processing and pain modulation play prominent roles in the maintenance of nociplastic pain. The hypothesis is that changes in the primary somesthetic cortex (S1) contribute to the generalized pain character of FM. The objective of this study was to evaluate the involvement of the primary somesthetic cortex in humans with fibromyalgia, as well as to investigate possible associations between S1 changes and clinical signs and symptoms of FM. CONTENTS: For this integrative review, the following databases were used: Pubmed and Web of Science, including observational studies carried out in humans with FM. In total, 541 studies were identified and four were included. The majority of studies are case-control studies, published between 2016 and 2022. In total, data from 161 individuals were included in this review. It was identified that there are morphological changes, hyperactivation and increased functional connectivity between S1 and periaqueductal gray matter and between S1 and anterior cingulate cortex. CONCLUSION: Patients with FM present morphological changes and hyperactivation in S1, as well as increased functional connectivity between S1 and periaqueductal gray matter and S1 and limbic system. Furthermore, different bilateral somatotropic subregions (legs, chest, fingers, hands, face and back) showed reduced functional connectivity in patients with FM. These regions are often presented as “tender points” in FM. OBJECTIVES FM, , (FM) understood however S (S1 CONTENTS review used Science total 54 casecontrol case control 201 2022 16 CONCLUSION system Furthermore legs, legs (legs chest fingers hands back tender points (FM (S 5 20 202 1 2

RESUMO: As conexões linfáticas regionais das glândulas mamárias em caninos são pouco investigadas, tanto em animais sadios quanto naqueles com neoplasmas mamários. Objetivou-se estabelecer à ocorrência de metástases nos linfonodos ilíacos mediais (MILN) em cadelas com neoplasma mamário, além de avaliar a eficácia da técnica de marcação linfática dos MILN, administrando o corante azul de metileno (MB) por via intrauterina ou intradérmica. Trinta e duas cadelas com neoplasmas malignos em diferentes glândulas mamárias foram incluídas no estudo. Em 13 cadelas (grupo GU), os MILNs foram corados com MB intrauterino, seguido de linfadenectomia unilateral, ovariohisterectomia (OVH) e mastectomia unilateral. Dezenove cães (grupo GI) foram submetidos a OVH, seguido de coloração MILN com MB intradérmico, linfadenectomia e mastectomia unilateral. No GU, 11 cães (84,62%) exibiram MILNs corados com MB, mas a coloração não foi observada em dois (15,38%). Metástases para MILNs foi observada em três cães (9,38%) do GI e em dois do GU (6,25%). A coloração intrauterina e intradérmica de MILNs em cadelas com tumores mamários foi eficiente, mas a administração intradérmica de MB produziu melhores resultados, observando a coloração de 100% dos linfonodos no GI e 84,62% no GU. Dada a disseminação metastática para MILNs em aproximadamente 15,63% dos pacientes, recomendamos que a investigação dos MILNs deve ser considerada como parte do estadiamento de animais com neoplasmas mamários malignos. RESUMO investigadas Objetivouse Objetivou se (MILN mamário (MB estudo 1 grupo , GU) intrauterino unilateral OVH (OVH intradérmico 8462 84 62 (84,62% 15,38%. 1538 15,38% . 15 38 (15,38%) 9,38% 938 9 (9,38% 6,25%. 625 6,25% 6 25 (6,25%) eficiente resultados 100 84,62 1563 63 15,63 pacientes 846 8 (84,62 153 15,38 3 (15,38% 9,38 93 (9,38 6,25 2 (6,25% 10 84,6 156 15,6 (84,6 15,3 (15,38 9,3 (9,3 6,2 (6,25 84, 15, (84, (15,3 9, (9, 6, (6,2 (84 (15, (9 (6, (8 (15 ( (6 (1

ABSTRACT: The regional lymphatic connections of the mammary glands in canines are poorly investigated, both in healthy animals and in those with mammary neoplasms. The objective was to establish the occurrence of metastases in the medial iliac lymph nodes (MILN) in bitches with mammary neoplasm, in addition to evaluating the effectiveness of the technique of lymphatic labeling of the MILN, administering methylene blue (MB) dye intrauterinely or intradermally. Thirty-two bitches with tumors in different mammary glands were included in the study. In 13 bitches (GU group), the MILNs were stained with intrauterine MB, followed by unilateral lymphadenectomy, ovariohysterectomy (OVH) and unilateral mastectomy. Nineteen bitches (GI group) underwent OVH, followed by MILN staining with intradermal MB, lymphadenectomy, and unilateral mastectomy. In GU, 11 bitches (84.62%) exhibited MB-stained MILNs, but staining was not observed in two (15.38%). Metastasis to MILNs was observed in three bitches (9.38%) from the GI and two (6.25%) from the GU. Intrauterine and intradermal staining of MILNs in bitches with mammary tumors was efficient, but intradermal administration of MB produced better results. Given metastatic spread to MILNs in approximately 15.63% of patients, we recommend that screening for MILNs should be considered as part of the staging of animals with malignant mammary neoplasms. ABSTRACT investigated neoplasms (MILN neoplasm (MB intradermally Thirtytwo Thirty study 1 GU group, group , lymphadenectomy OVH (OVH mastectomy 84.62% 8462 84 62 (84.62% MBstained 15.38%. 1538 15.38% . 15 38 (15.38%) 9.38% 938 9 (9.38% 6.25% 625 6 25 (6.25% efficient results 1563 63 15.63 patients 84.62 846 8 (84.62 153 15.38 3 (15.38% 9.38 93 (9.38 6.25 2 (6.25 156 15.6 84.6 (84.6 15.3 (15.38 9.3 (9.3 6.2 (6.2 15. 84. (84. (15.3 9. (9. 6. (6. (84 (15. (9 (6 (8 (15 ( (1

RESUMO JUSTIFICATIVA E OBJETIVOS: As fraturas ósseas constituem causa frequente de atendimento de emergência na população pediátrica. Fármacos opioides são rotineiramente utilizados para analgesia durante a hospitalização de crianças vítimas de trauma. Poucos estudos avaliaram a importância de uma abordagem multimodal para analgesia nesse contexto. O objetivo deste estudo foi comparar o efeito analgésico e possíveis efeitos adversos do fentanil em relação aos da cetamina. MÉTODOS: Foram analisados 50 crianças e adolescentes, com idade entre 24 e 192 meses, submetidos ao tratamento cirúrgico das fraturas de membros superiores em um hospital terciário de atendimento ao trauma. Os participantes foram aleatorizados em dois grupos: um recebeu cetamina e outro fentanil. Na sala de recuperação pós-anestésica (SRPA), a intensidade da dor e a ocorrência de delirium foram mensuradas por um período de 30 minutos. A incidência de depressão respiratória, náuseas, vômitos e outros efeitos adversos durante o procedimento cirúrgico foram avaliados. RESULTADOS: A amostra foi composta, em sua maioria, por indivíduos do sexo masculino (76,0%). A média de idade dos participantes foi de 90,1 meses. O uso de cânula de oxigênio de baixo fluxo foi necessário em 30,0% dos participantes. A incidência de vômitos e laringoespasmo foi de 2,0% entre os participantes, sendo que 6,0% apresentaram aumento da secreção salivar. A ocorrência de dor, delirium e depressão respiratória não foi diferente entre os dois grupos avaliados, assim como a ocorrência de náuseas e laringoespasmo. CONCLUSAO: Acetamina não se mostrou uma opção eficaz e segura aos opioides para analgesia em crianças submetidas a procedimentos cirúrgicos para tratamento de fraturas de membros superiores. OBJETIVOS pediátrica trauma contexto MÉTODOS 5 adolescentes 2 19 meses pósanestésica pós anestésica SRPA, SRPA , (SRPA) 3 minutos avaliados RESULTADOS composta maioria 76,0%. 760 76,0% . 76 0 (76,0%) 901 90 1 90, 300 30,0 20 2,0 60 6 6,0 salivar CONCLUSAO (SRPA 76,0 7 (76,0% 9 30, 2, 6, 76, (76,0 (76, (76 (7 (

ABSTRACT BACKGROUND AND OBJECTIVES: Bone fractures constitute a frequent cause of emergency care in the pediatric population. Opioid drugs are routinely used for analgesia during the hospitalization of children victims of trauma. Few studies have evaluated the importance of a multimodal approach to analgesia in this context. The aim of this study was to compare the analgesic effect and possible side effects of fentanyl compared to those of ketamine. METHODS: The study analyzed 50 children and adolescents, aged between 24 and 192 months, submitted to surgical treatment of upper limb fractures in a tertiary trauma care hospital. The participants were randomized into two groups: one that received Ketamine and the other Fentanyl. In the post-anesthetic recovery room (PARR), pain intensity and the occurrence of delirium were measured for a period of 30 minutes. The incidence of respiratory depression, nausea, vomiting and other side effects during the surgical procedure were assessed. RESULTS: The sample consisted mostly of male individuals (76.0%). The mean age of the participants was 90.1 months. The use of a low-flow oxygen cannula was necessary in 30.0% of the participants. The incidence of vomiting and laryngospasm was 2.0% among the participants, and 6.0% presented increased salivary secretion. The occurrence of pain, delirium and respiratory depression was not different between the two assessed groups, as well as the occurrence of nausea and laryngospasm. CONCLUSION: Ketamine is not an effective and safe option to opioids for analgesia in children undergoing surgical procedures to treat upper limb fractures. OBJECTIVES population context ketamine METHODS 5 adolescents 2 19 months hospital groups Fentanyl postanesthetic post anesthetic PARR, PARR , (PARR) 3 minutes RESULTS 76.0%. 760 76.0% . 76 0 (76.0%) 901 90 1 90. lowflow low flow 300 30.0 20 2.0 60 6 6.0 secretion CONCLUSION (PARR 76.0 7 (76.0% 9 30. 2. 6. 76. (76.0 (76. (76 (7 (

RESUMO Contexto: Nas últimas décadas, a ecoendoscopia evoluiu de uma ferramenta diagnóstica para uma plataforma para diversas intervenções terapêuticas. Vários avanços tecnológicos surgiram desde o último Consenso Brasileiro, demandando uma revisão e atualização das recomendações baseadas nas melhores evidências científicas. Métodos: Um grupo de 32 ecoendoscopistas renomados selecionou oito tópicos relevantes para serem discutidos a fim de gerar questões clínicas. Em seguida, foi realizada uma revisão da literatura para responder a essas perguntas com base nas evidências mais atualizadas. Resultados: Trinta e três tópicos foram formulados e votados pelos especialistas para alcançar um consenso. O Sistema de Oxford foi utilizado para classificar o nível de evidência. Conclusão: Há evidências moderadas para sustentar que a forma da agulha, calibre ou técnica de aspiração não influenciam no rendimento da amostragem tecidual guiada por ultrassom endoscópico (USE) de lesões sólidas pancreáticas. Há evidências moderadas para sustentar o uso da biópsia transcutânea guiada por USE da parede cística para diferenciar entre neoplasias císticas mucinosas e não mucinosas. Existem poucas evidências para apoiar o tratamento guiado por USE de varizes gástricas. Há um alto nível de evidência para sustentar que a drenagem biliar guiada por USE e a CPRE apresentam resultados semelhantes em pacientes com obstrução biliar maligna distal. Há um alto nível de evidência para o uso da USE no diagnóstico de cistos pancreáticos neoplásicos e na detecção de necrose antes de indicar a drenagem. Há evidências moderadas para sustentar a preferência pela gastroenterostomia guiada por USE em relação ao stent duodenal para obstrução maligna da saída gástrica em pacientes com expectativa de vida superior a 2 meses. Há um alto nível de evidência para sustentar o uso da ablação por radiofrequência no tratamento de ambos os tipos, funcionantes e não funcionantes, de tumores neuroendócrinos. Contexto décadas terapêuticas Brasileiro científicas Métodos 3 clínicas seguida atualizadas Resultados consenso Conclusão agulha (USE pancreáticas gástricas distal meses tipos neuroendócrinos

ABSTRACT Background: In the past decades, endoscopic ultrasound has developed from a diagnostic tool to a platform for many therapeutic interventions. Various technological advancements have emerged since the last Brazilian Consensus, demanding a review and update of the recommendations based on the best scientific evidence. Methods: A group of 32 renowned echoendoscopists selected eight relevant topics to be discussed to generate clinical questions. After that, a literature review was conducted to answer these questions based on the most updated evidence. Results: Thirty-three statements were formulated and voted on by the experts to reach a consensus. The Oxford System was used to grade the level of evidence. Conclusion: There is moderate evidence to support that the needle shape, gauge, or aspiration technique does not influence the yield of endoscopic ultrasound (EUS)-guided tissue sampling of pancreatic solid lesions. There is moderate evidence to support using EUS-TTNB of the cyst wall to differentiate between mucinous and non-mucinous cystic neoplasms. There is little evidence to support the EUS-guided treatment of gastric varices. There is a high level of evidence to support that EUS-guided biliary drainage and ERCP present similar outcomes in patients with distal malignant biliary obstruction. There is a high level of evidence for using EUS to diagnose neoplastic pancreatic cysts and detect necrosis before indicating drainage. There is moderate evidence to support EUS-GE over duodenal stent for malignant gastric outlet obstruction in patients with a life expectancy higher than 2 months. There is a high level of evidence to support the use of RFA in treating both functioning and non-functioning types of NET. Background decades interventions Consensus Methods 3 Results Thirtythree Thirty three consensus Conclusion shape gauge EUSguided guided lesions EUSTTNB TTNB nonmucinous non neoplasms varices EUSGE GE months nonfunctioning NET

RESUMO Objetivo Caracterizar o consumo de adoçantes não nutritivos e verificar a associação entre a ingestão desses aditivos e a prevalência de Hipertensão Arterial Sistêmica em adultos e idosos de uma capital brasileira. Métodos Estudo transversal de base populacional e domiciliar realizado com 489 indivíduos com 20 anos ou mais residentes em Teresina, Piauí, Brasil. Foi utilizada amostragem probabilística complexa por conglomerados. Dados sociodemográficos, econômicos, de estilo de vida e de diagnóstico de doenças, como Hipertensão Arterial Sistêmica, foram autorrelatados. Foram aferidos o peso, a altura, a circunferência da cintura e a pressão arterial. O consumo alimentar e de adoçantes não nutritivos foram avaliados por meio de recordatório alimentar de 24 horas. A associação entre o consumo de adoçantes não nutritivos e a prevalência de Hipertensão Arterial Sistêmica foi verificada por meio da regressão de Poisson. Resultados Os tipos de adoçantes não nutritivos mais comumente consumidos foram o ciclamato e a sacarina, e a principal fonte de consumo foram os adoçantes de mesa. O consumo de adoçantes não nutritivos foi bem inferior à Ingestão Diária Aceitável. A pressão arterial sistólica e a pressão arterial diastólica foram mais elevadas em mulheres e homens que consumiam adoçantes não nutritivos (p=0,04), respectivamente. Os indivíduos que consumiam adoçantes não nutritivos apresentaram 36% maior prevalência de Hipertensão Arterial Sistêmica em comparação aos não consumidores (p=0,04), após ajustes. As mulheres consumidoras de adoçantes não nutritivos apresentaram uma prevalência 31% maior de Hipertensão Arterial Sistêmica (p=0,04). Conclusão O consumo de adoçantes não nutritivos foi positivamente associado à prevalência de Hipertensão Arterial Sistêmica. Portanto, é importante dar continuidade aos estudos que investigam as possíveis consequências do consumo dessas substâncias para a saúde. brasileira 48 2 Teresina Piauí Brasil conglomerados sociodemográficos econômicos doenças autorrelatados peso altura horas Poisson sacarina mesa Aceitável p=0,04, p004 p p=0,04 , 0 04 (p=0,04) respectivamente 36 ajustes 31 p=0,04. . Portanto saúde 4 p00 p=0,0 (p=0,04 3 p0 p=0, (p=0,0 p=0 (p=0, p= (p=0 (p= (p

ABSTRACT Objective To characterize the consumption of Non-nutritive sweeteners and to verify the association between the intake of these additives and the prevalence of Systemic Arterial Hypertension in adults and the elderly in a Brazilian capital. Methods This was a cross-sectional household and population-based study carried out with 489 individuals aged 20 years and older residents of Teresina, Piauí, Brazil. Complex probabilistic cluster sampling was used. Sociodemographic, economic, lifestyle and diseases diagnosis, such as SAH diagnosis, data were obtained by self-report. Weight, height, waist circumference and blood pressure were measured. Data on food consumption and Non-nutritive sweeteners consumption were obtained using 24-hour dietary recall. The association between the consumption of Non-nutritive sweeteners and the prevalence of Systemic Arterial Hypertension was verified using Poisson regression. Results The most commonly consumed types of Non-nutritive sweeteners were cyclamate and saccharin and the main source of consumption was tabletop sweeteners. The consumption of Non-nutritive sweeteners was well below the Acceptable Daily Intake. Mean systolic blood pressure and diastolic blood pressure were higher in women and men who consumed Non-nutritive sweeteners (p=0.04), respectively. Individuals who consumed Non-nutritive sweeteners had a 36% higher prevalence of Systemic Arterial Hypertension compared to non-consumers (p=0.04), after adjustments. Female consumers of Non-nutritive sweeteners had a 31% higher prevalence of Systemic Arterial Hypertension (No-BreakpNo-Break=0.04). Conclusion The consumption of Non-nutritive sweeteners was positively associated with the prevalence of Systemic Arterial Hypertension. It is therefore important to continue studies investigating the possible health consequences of consuming these substances. Nonnutritive Non nutritive capital crosssectional cross sectional populationbased population based 48 2 Teresina Piauí Brazil used Sociodemographic economic diagnosis selfreport. selfreport self report. report self-report Weight height measured 24hour hour 24 recall regression Intake p=0.04, p004 p p=0.04 , 0 04 (p=0.04) respectively 36 nonconsumers non adjustments 31 NoBreakpNoBreak=0.04. NoBreakpNoBreak004 NoBreakpNoBreak No BreakpNo Break=0.04 . Break (No-BreakpNo-Break=0.04) substances 4 p00 p=0.0 (p=0.04 3 NoBreakpNoBreak=0.04 NoBreakpNoBreak00 Break004 Break=0.0 (No-BreakpNo-Break=0.04 p0 p=0. (p=0.0 NoBreakpNoBreak=0.0 NoBreakpNoBreak0 Break00 Break=0. (No-BreakpNo-Break=0.0 p=0 (p=0. NoBreakpNoBreak=0. Break0 Break=0 (No-BreakpNo-Break=0. p= (p=0 NoBreakpNoBreak=0 Break= (No-BreakpNo-Break=0 (p= NoBreakpNoBreak= (No-BreakpNo-Break= (p (No-BreakpNo-Break

Abstract This study evaluated the effect of different occlusal surface finishes (glaze and silica glass infiltration) on surface characteristics and fatigue behavior of partially stabilized zirconia (PSZ) plates adhesively bonded onto epoxy resin discs. PSZ disc specimens (n = 15; Katana blocks STML, Kuraray Noritake Dental) were produced (Ø = 10 mm; thickness = 1.2 mm) and allocated into 3 groups: As sintered (S), silica glass infiltration (SGI), and glaze application (G). The PSZ intaglio surface was air-abraded with 50-µm alumina powder followed by bonding agent application. All produced PSZ were adhesively cemented onto dentin analogue discs made of epoxy resin material (Ø = 10 mm; thickness = 2 mm). Step stress fatigue test was performed (load ranging from 200 to 1800 N; step size 100 N and 10,000 cycles; 20 Hz). The topographic, microstructural, and fractographic analyses were performed by scanning electron microscopy. Results: No statistically significant difference in fatigue behavior was detected among the groups. All failures started at the bonding surface. Silica glass-infiltration and glaze layer application provided a smoothing effect, while the sintered group had a surface with grooves. The occlusal surface finishing method (silica glass infiltration or glazing) had no deleterious effect on fatigue behavior of adhesively bonded PSZ plates. (PSZ n 15 STML Dental Ø 1 mm 12 1. groups S, S , (S) SGI, SGI (SGI) G. G . (G) airabraded air abraded 50µm µm 50 mm. load 180 10000 000 10,00 cycles Hz. Hz Hz) topographic microstructural microscopy Results glassinfiltration grooves glazing (S (SGI (G 5 18 1000 00 10,0 0 10,