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RESUMO Objetivo: Avaliar o desenvolvimento cognitivo de crianças pré-termo aos seis e 12 meses de idade corrigida e as associações com fatores perinatais e socioeconômicos. Métodos: O desenvolvimento cognitivo de 40 crianças (20 pré-termo e 20 a termo) foi avaliado aos seis e 12 meses de idade, utilizando a escala Bayley-III. Correlações entre resultados cognitivos e fatores associados foram avaliadas pelo teste de correlação de Spearman. A análise de regressão linear múltipla stepwise com covariância foi aplicada para identificar mudanças na pontuação cognitiva entre seis e 12 meses. Resultados: O escore cognitivo no grupo pré-termo foi significativamente menor que no grupo a termo aos seis e 12 meses. O peso ao nascer foi diretamente associado com o desempenho cognitivo aos seis meses e perímetro cefálico ao nascimento aos 12 meses, nas crianças a termo. A ocorrência de enterocolite necrosante foi inversamente associada ao desempenho cognitivo em pré-termos, aos 12 meses. Verificou-se aumento na pontuação cognitiva entre seis e 12 meses nos dois grupos, porém mais pronunciado no pré-termo. Conclusões: O estudo sugere que crianças pré-termo apresentam alguma capacidade de recuperação cognitiva no primeiro ano, apesar das restrições impostas pelo nascimento prematuro, e enfatizam a importância de acompanhamento dessa população desde os primeiros meses de vida. Objetivo prétermo pré 1 socioeconômicos Métodos 4 (2 2 BayleyIII. BayleyIII Bayley III. III Bayley-III Spearman Resultados prétermos, prétermos termos, termos pré-termos Verificouse Verificou se grupos prétermo. Conclusões ano prematuro vida (

ABSTRACT Objective: To analyze the cognitive development of preterm infants at six and 12 months of corrected age and the associations with perinatal and socioeconomic factors. Methods: Cognitive development of 40 infants (20 preterm and 20 full-term) at six and 12 months of age was evaluated using the Bayley-III scale. Correlations between cognitive outcome and associated factors were assessed using Spearman correlation. Stepwise multiple linear regression analysis with covariance was applied to identify changes on cognitive score between six and 12 months. Results: Bayley-III cognitive score in preterm group was significantly lower than in full-term group at both six and 12 months of age. Birth weight correlated with cognitive performance at six months and head circumference at birth at 12 months, in full-terms infants. The occurrence of necrotizing enterocolitis was inversely associated with cognitive score in preterms at 12 months. An increase in cognitive score was observed between six and 12 months in both groups, but the gain was more pronounced in preterms. Conclusions: These findings suggest some cognitive recovery capacity in the first year despite the restrictions imposed by premature birth and emphasize the importance of early interventions in this population. Objective 1 Methods 4 (2 2 fullterm full term BayleyIII Bayley III scale correlation Results fullterms terms groups Conclusions population (

https://doi.org/10.1590/1984-0462/2024/42/2022164

Pomegranate oil-based nanocapsules enhance 3,3’-diindolylmethane action against melanoma cells oilbased oil based 3,3diindolylmethane 33diindolylmethane diindolylmethane 3,3 3 3diindolylmethane 33 3,
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Reolon, Jéssica Brandão

; Merg, Carina Dinah

; Oliveira, Daiane Britto de

; Cabral, Fernanda Licker

; Osmari, Bárbara Felin

; Sari, Marcel Henrique Marcondes

; Brucker, Natália

; Leal, Daniela Bitencourt Rosa

; Cruz, Letícia

Brazilian Journal of Pharmaceutical Sciences

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2024, Volume 60 elocation e23931

Abstract: En | Text: En | PDF: En

Abstract Cutaneous melanoma, a highly aggressive skin cancer, is the leading cause of death among skin neoplasms. Hence, this study focused on developing a 3,3'-diindolylmethane (DIM)-loaded pomegranate oil (PO) nanocapsule suspensions and their potential effects on melanoma cells. Nanocapsule suspensions were prepared by the interfacial deposition method (Eudragit ® RS100). Medium-chain triglyceride (MCT) nanocapsules were produced for comparison. The of nanocapsule suspensions showed nanometric size (<180 nm), low polydispersity index (<0.12) (as measured by dynamic light scattering), positive zeta potential (tested by capillary microelectrophoresis), pH below 5.0 (as measured by potentiometry), DIM content, and nearly 100% encapsulation efficiency (evaluated by HPLC). The formulations were considered non-irritating (according to HET-CAM) regardless of the core constitution. Notably, PO-based nanocapsules showed a superior performance compared to the MCT-containing formulation in delaying DIM light degradation (tested by UVC radiation), lowering genotoxicity (determined by Allium cepa ), and increasing in vitro antioxidant action (measured by ABTS and FRAP). Additionally, the PO-based formulation demonstrated higher in vitro antitumoral activity in B16F10 than MCT nanocarriers (IC 50 of 6.49 and >24 µg/mL, respectively), and antimetastatic capacity by reducing B16F10 cell adhesion, colonization, and migration. Based on these results, this study suggests that the nanoencapsulation of DIM into PO nanocapsules may be a promising approach in melanoma treatment. cancer neoplasms Hence 3,3diindolylmethane 33diindolylmethane diindolylmethane 3,3 3 DIMloaded loaded (PO cells Eudragit RS100. RS100 RS . RS100) Mediumchain Medium chain (MCT comparison <180 180 (<18 nm, nm , nm) <0.12 012 0 12 (<0.12 as scattering, scattering scattering) tested microelectrophoresis, microelectrophoresis microelectrophoresis) 5 5. potentiometry, potentiometry potentiometry) content 100 evaluated HPLC. HPLC HPLC) nonirritating non irritating according HETCAM HET CAM HET-CAM constitution Notably PObased based MCTcontaining containing radiation, radiation radiation) determined ) FRAP. FRAP FRAP) Additionally BF B F B16F1 IC 649 6 49 6.4 24 >2 µgmL µg mL µg/mL respectively, respectively respectively) adhesion colonization migration results treatment 3diindolylmethane 33 3, RS10 <18 18 (<1 <0.1 01 1 (<0.1 10 B16F 64 4 6. 2 > RS1 <1 (< <0. (<0. < ( <0 (<0

https://doi.org/10.1590/s2175-97902024e23931

Impact on pulmonary, cardiac, and renal function and long-term quality of life after hospitalization for acute respiratory distress syndrome due to COVID-19: Protocol of the Post-COVID Brazil 3 study pulmonary cardiac longterm long term COVID19 COVID 19 COVID-19 PostCOVID Post COVID1 1 COVID-1 COVID-
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Scolari, Fernando Luís

; Rover, Marciane Maria

; Trott, Geraldine

; da Silva, Mariana Motta Dias

; de Souza, Denise

; de Carli Schardosim, Raine Fogliati

; da Rosa Minho dos Santos, Rosa

; de Souza Roldão, Emelyn

; Mocellin, Duane

; de Souza, Jennifer Menna Barreto

; Miozzo, Aline Paula

; Rech, Gabriela Soares

; Itaqui, Carolina Rothmann

; de Mesquita Neto, Juliana

; Estivalete, Gabriel Pozza Muller

; Freitas, Hellen Jordan Martins

; dos Santos, Catherine Vitória Pereira

; da Luz, Lucas Gobetti

; Kern, Marcelo

; Marcolino, Milena Soriano

; Barreto, Bruna Brandão

; Schwartzman, Paulo R.

; Antonio, Ana Carolina Peçanha

; Falavigna, Maicon

; Robinson, Caroline Cabral

; Polanczy, Carisi Anne

; Rosa, Regis Goulart

Critical Care Science

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2024, Volume 36 elocation e20240258en

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Fundamento: As evidências acerca das sequelas a longo prazo após internação por síndrome do desconforto respiratório agudo por COVID-19 ainda são escassas. Objetivo: Avaliar alterações nas funções pulmonar, cardíaca e renal e na qualidade de vida após internação por síndrome do desconforto respiratório agudo secundária à COVID-19. Métodos: Trata-se de estudo multicêntrico, caso-controle, incluindo 220 participantes. Os casos serão definidos como pacientes hospitalizados por síndrome do desconforto respiratório agudo devido à COVID-19. No Grupo Controle, serão selecionados indivíduos sem histórico de hospitalização nos últimos 12 meses ou sintomas a longo prazo de COVID-19. Todos os indivíduos serão submetidos à espirometria pulmonar com teste de difusão pelo monóxido de carbono, tomografia de tórax, ressonância magnética cardíaca e renal com gadolínio, ergoespirometria, creatinina sérica e urinária, proteínas totais e microalbuminúria urinária, além de questionários de qualidade de vida. Os casos serão avaliados 12 meses após a alta hospitalar e os controles, 90 dias após a inclusão no estudo. Para todas as análises estatísticas, será assumido como significativo o valor p < 0,05. Resultados: O desfecho primário do estudo foi definido com a capacidade de difusão pulmonar aferida para o monóxido de carbono a partir de 12 meses. Os demais parâmetros das funções pulmonar, cardíacas e renal e da qualidade de vida foram definidos como desfechos secundários. Conclusão: Este estudo visa determinar as sequelas a longo prazo nas funções pulmonar, cardíaca e renal e na qualidade de vida de pacientes internados por síndrome do desconforto respiratório agudo devido à COVID-19 na população brasileira. Fundamento COVID19 COVID 19 COVID-1 escassas Objetivo COVID19. 19. Métodos Tratase Trata se multicêntrico casocontrole, casocontrole caso controle, controle caso-controle 22 participantes Controle 1 tórax gadolínio ergoespirometria urinária controles 9 estatísticas 005 0 05 0,05 Resultados secundários Conclusão brasileira COVID1 COVID- 2 00 0,0 0,

ABSTRACT Rationale: Evidence about long-term sequelae after hospitalization for acute respiratory distress syndrome due to COVID-19 is still scarce. Purpose: To evaluate changes in pulmonary, cardiac, and renal function and in quality of life after hospitalization for acute respiratory distress syndrome secondary to COVID-19. Methods: This will be a multicenter case–control study of 220 participants. Eligible are patients who are hospitalized for acute respiratory distress syndrome due to COVID-19. In the control group, individuals with no history of hospitalization in the last 12 months or long-term symptoms of COVID-19 will be selected. All individuals will be subjected to pulmonary spirometry with a carbon monoxide diffusion test, chest tomography, cardiac and renal magnetic resonance imaging with gadolinium, ergospirometry, serum and urinary creatinine, total protein, and urinary microalbuminuria, in addition to quality-of-life questionnaires. Patients will be evaluated 12 months after hospital discharge, and controls will be evaluated within 90 days of inclusion in the study. For all the statistical analyses, p < 0.05 is the threshold for significance. Results: The primary outcome of the study will be the pulmonary diffusing capacity for carbon monoxide measured after 12 months. The other parameters of pulmonary, cardiac, and renal function and quality of life are secondary outcomes. Conclusion: This study aims to determine the long-term sequelae of pulmonary, cardiac, and renal function and the quality of life of patients hospitalized for acute respiratory distress syndrome due to COVID-19 in the Brazilian population. Rationale longterm long term COVID19 COVID 19 COVID-1 scarce Purpose COVID19. 19. Methods casecontrol case 22 participants group 1 selected test tomography gadolinium ergospirometry creatinine protein microalbuminuria qualityoflife questionnaires discharge 9 analyses 005 0 05 0.0 significance Results outcomes Conclusion population COVID1 COVID- 2 00 0.

https://doi.org/10.62675/2965-2774.20240258-en

Performance of Spray-Dried Nanofibrillated Cellulose as Wood Varnish Reinforcement in Outdoor Environment SprayDried Spray Dried
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Fonte, Ana Paula Namikata da

; Cabral, Bruna Mulinari

; Lins, Tarcila Rosa da Silva

; Carneiro, Mayara Elita

; Lengowski, Elaine Cristina

; Bonfatti Júnior, Eraldo Antonio

; Klock, Umberto

; Andrade, Alan Sulato de

; Silva, Dimas Agostinho da

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24231048

Abstract: En | Text: En | PDF: En

Abstract The outdoor use of wood can be improved by coating the wood surface with varnish to reduce the effects of natural weathering. However, some varnishes quickly lose their ability to protect wood, and nanoscale additives have been used to mitigate this negative effect, preferably renewable and biodegradable. Therefore, the objective of this study was to evaluate the performance of varnishes reinforced with spray-dried nanofibrillated cellulose (NFC) in a natural weathering test. For this purpose, two varnishes, waterborne and non-waterborne, with 0, 5, and 10% (w/w) NFC addition were applied to Pinus taeda tangential wood samples, which were exposed to natural weathering for half a year, during the period from January to June 2019, in Curitiba, PR, Brazil. Adherence and impact resistance tests were performed to evaluate the surface properties of the varnishes, and the effect of natural weathering on the wood surface was evaluated using quantitative colorimetric analyses (CIELab System). The varnishes did not perform well in the adhesion and impact test. While no significant effects were observed in surface tests, due to the addition of spray-dried NFC, varnishes reinforced with 5% NFC exhibited reduced overall color variation, maintaining yellow and red pigmentation. This suggests that incorporating 5% spray-dried NFC into varnishes did not compromise coating properties and aided in mitigating the impact of natural weathering on wood color variation. However biodegradable Therefore spraydried spray dried (NFC test purpose nonwaterborne, nonwaterborne non waterborne, non-waterborne 0 5 10 w/w ww w (w/w samples year 2019 Curitiba PR Brazil CIELab System. System . System) variation pigmentation 1 201 20 2

https://doi.org/10.1590/1678-4324-2024231048

Effect of dried distillers’ grains on nutrients digestibility and nitrogen metabolism of Nellore cattle fed non-forage diets distillers nonforage non forage
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Rosa e Silva, Pedro Ivo José Lopes da

; Silva, Yasmim Rodrigues Vilas Boas e

; Sousa, Daniel de Paula

; Paulino, Pedro Veiga Rodrigues

; Possamai, Adriano Jorge

; Freiria, Lucien Bissi da

; Rolim, Henrique Castrillon Leiva

; Dias Júnior, Waldir de Castro

; Fonseca, Alessandra Schaphauser Rosseto

; Costa, Ana Cláudia da

; Negrão, Fagton de Mattos

; Cabral, Luciano da Silva

Revista Brasileira de Zootecnia

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2024, Volume 53 elocation e20240045

Abstract: En | Text: En | PDF: En

ABSTRACT This study was carried out to evaluate the effects of corn dried distillers’ grains (DDG) levels in non-forage diets by in vitro, in situ (0 to 50%), and in vivo (0 to 40%) trials on kinetic parameters of gas production (GP) on rumen-degradable protein (RDP) and rumen-undegradable protein (RUP) as well as on nitrogen (N) metabolism in Nellore cattle. For in vitro and in situ studies, three rumen cannulated Nellore males with body weight of 340.48 ± 22.22 kg were used. For the in vivo study, five non-castrated male Nellore cattle with an initial body weight of 355.20 ± 35.28 kg and 24 ± 3 months old were used to evaluate the effect of increasing DDG levels in non-forage diets on N metabolism by a 5 × 5 Latin square design. Experimental diets were based on ground corn, cottonseed cake, urea, mineral supplement, and increasing levels of DDG replacing ground corn. The DDG levels caused a linear decrease in GP and in vitro dry matter digestibility. The DDG presented a lower dry matter digestibility (DMD) and RDP and higher RUP than corn grain and cottonseed cake, making DDG diets present lower DMD and RDP than control. The DDG levels linearly increased the intake of crude protein, neutral detergent fiber, and ether extract, whereas non-fiber carbohydrates intake decreased and tended to decrease the DMD and organic matter digestibility. The DDG levels caused a linear increase in N intake and in total, fecal, and urinary N excretion, which was the major N excretion route, causing a quadratic drop in retained N and caused a quadratic effect on alanine aminotransferase. In contrast, triglycerides were cubically affected, and total blood protein increased. Thus, DDG levels negatively affect in vitro and in situ digestibility, increasing N intake but increasing urinary N excretion. distillers (DDG nonforage non forage 0 ( 50%, 50 50% , 50%) 40% 40 (GP rumendegradable degradable (RDP rumenundegradable undegradable (RUP (N studies 34048 340 48 340.4 2222 22 22.2 noncastrated castrated 35520 355 20 355.2 3528 35 28 35.2 2 design cake urea supplement (DMD control fiber extract nonfiber fecal route aminotransferase contrast affected Thus 4 3404 34 340. 222 22. 3552 355. 352 35.

https://doi.org/10.37496/rbz5320240045

Análisis comparativo de las características clínicas, evolución y mortalidad de pacientes hospitalizados por COVID-19 durante la primera y segunda ola de la pandemia (REGISTRO ECCOVID)
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Córdova, Ezequiel

; Mykietiuk, Analia

; de Vedia, Lautaro

; Bacelar, Brenda

; Cáceres, María Florencia

; Nemirovsky, Corina

; Contreras, Rosa

; Alzogaray, Maria Fernanda

; Nannini, Esteban

; Consalvo, María Fernanda

; Soler Puy, Lucrecia

; Scapellato, Pablo G.

; Barcelona, Laura

; Golikow, Mariana L.

; Piñeiro, María Florencia

; Miño, Hugo J.

; Cabral, Myrna

; Lamponi Tappata, Lucía

; Lopardo, Gustavo

; Sued, Omar

; Stryjewski, Martín E.

Medicina (Buenos Aires)

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aug 2023, Volume 83 N. 4 Pages 551 - 557

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción : Las características clínicas y evolutivas de los pacientes con diagnóstico de COVID-19 pueden diferir entre las distintas olas de la pandemia. El objetivo de este estudio fue comparar las características clínicas, evolución y mortalidad de pacientes hospitalizados por COVID-19 durante la primera y segunda ola en Argentina. Métodos : Registro multicéntrico y prospectivo de pacientes ≥ 18 años con diagnóstico confirmado de COVID-19 internados en 18 hospitales de Argentina durante la primera (marzo a octubre 2020) y la segunda ola (marzo a julio 2021) de la pandemia. Se compararon variables demográficas, características clínicas, y evolu ción a 30 días. Resultados : Se incluyeron un total de 1691 pacien tes (primera ola n = 809, segunda ola n = 882). Los pa cientes hospitalizados durante la segunda ola tenían mayor edad (mediana 53 años vs. 61 años, p < 0.001), comorbilidades (71% vs. 77%, p = 0.007) y requerimiento de oxígeno (21% vs. 62%, p < 0.001). Durante la hospi talización, los pacientes de la segunda ola requirieron más oxigenoterapia (49% vs. 85%, p < 0.001), asistencia mecánica respiratoria (12% vs. 22%, p <0,001) y presen taron mayor mortalidad (11% vs. 26%, p < 0.001). Compa rando únicamente a los que requirieron oxigenoterapia durante la hospitalización, la mortalidad a los 30 días fue de 20% y 30% p < 0.001 en la primera y segunda ola respectivamente. Conclusión : Comparados con los pacientes interna dos durante la primera ola, los internados durante la segunda ola de SARS-CoV-2 en Argentina presentaron mayor gravedad y mortalidad.

Abstract Introduction : Clinical features and outcomes of SARS-CoV-2 infections may change between different waves of the pandemic. The objective of this study was to compare clinical characteristics and outcomes between two cohorts of patients hospitalized for COVID-19 during the first and second waves in Argentina. Methods : Multicenter and prospective registry of patients ≥18 years old with a confirmed diagnosis of COVID-19 admitted to 18 hospitals in Argentina during the first wave (March to October 2020) and second wave (March to July 2021) of the pandemic. Demographics, clinical characteristics, and outcomes of these patients were compared. Results : A total of 1691 patients were included (first wave n = 809, second wave n = 882). Hospitalized pa tients during the second wave were older (median 53 years vs. 61 years, p < 0.001), had more comorbidities (71% vs. 77%, p=0.007) and required more supplemental oxygen at admission (21% vs 62%, p < 0.001). During hos pitalization, patients of the second wave required more supplemental oxygen (49% vs. 85%, p < 0.001), invasive ventilation (12% vs. 22%, p < 0.001) and had higher 30- day mortality (11% vs. 26%, p < 0.001). Comparing only patients who required supplemental oxygen during hos pitalization, 30-day mortality was 20% and 30% p < 0.001 for the first and second wave, respectively. Conclusion : Compared to patients admitted during the first wave, patients admitted with SARS-CoV2 dur ing the second wave in Argentina were more seriously ill and had a higher mortality.

Prevalência de uso de álcool na gestação, Brasil, 2011-2012 gestação Brasil 20112012 2011 2012 2011-201 2011201 201 2011-20 201120 20 2011-2 20112 2 2011-
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Cabral, Vanderlea Poeys

; Moraes, Claudia Leite de

; Bastos, Francisco I.

; Abreu, Angela Maria Mendes

; Domingues, Rosa Maria Soares Madeira

Cadernos de Saúde Pública

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2023, Volume 39 N. 8 elocation e00232422

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Resumen: Estudio transversal, de base hospitalaria, nacional, con entrevistas a 23.894 puérperas, en 2011-2012, con el objetivo de estimar la prevalencia de consumo de alcohol durante el embarazo e identificar grupos más vulnerables. El consumo de alcohol durante el embarazo se identificó mediante la escala TWEAK, y las mujeres con puntuación ≥ 2 fueron clasificadas como “diagnóstico presumible de uso inadecuado de alcohol¨. Se calculó la prevalencia nacional de consumo de alcohol y subgrupos según características maternas, con sus respectivos intervalos de 95% de confianza (IC95%). Se identificó gráficamente la coexistencia de tabaquismo, consultas prenatales inadecuadas y consumo de alcohol durante el embarazo. La prevalencia de consumo de alcohol fue del 14% (IC95%: 13,3-14,7), siendo el 10% (IC95%: 9,3-10,6) de mujeres con diagnóstico presumible de uso inadecuado durante el embarazo. Se observaron mayores prevalencias de consumo de alcohol y diagnóstico presumible de uso inadecuado en mujeres de color/raza negra, de 12-19 años, con menos años de escolaridad, de clase económica más baja, sin pareja, sin trabajo remunerado, con más de tres partos previos, que no querían quedar embarazadas, con control prenatal inadecuado, con parto en el sistema público de salud y que relataron fumar durante el embarazo. Se estima que el 1,2% de las mujeres entrevistadas presentaron la concomitancia de tres factores de riesgo en resultados perinatales negativos: tabaquismo, alcohol y atención prenatal inadecuada. Los resultados demuestran una alta prevalencia de consumo de alcohol durante el embarazo y de diagnóstico presumible de uso inadecuado, especialmente en mujeres con las peores condiciones sociales, siendo relevante para la elaboración de políticas públicas que incluyan acciones de prevención del consumo de alcohol y servicios de apoyo para el cese del consumo de alcohol en el embarazo. Resumen transversal hospitalaria 23894 23 894 23.89 puérperas 20112012, 20112012 2011 2012, 2012 2011-2012 vulnerables TWEAK alcohol¨ maternas 95 IC95%. IC95 IC IC95% . (IC95%) tabaquismo 14 (IC95% 13,314,7, 133147 13,3 14,7 , 13 3 7 13,3-14,7) 10 9,310,6 93106 9,3 10,6 9 6 9,3-10,6 colorraza color raza negra 1219 12 19 12-1 escolaridad baja pareja remunerado previos embarazadas 1 1,2 negativos inadecuada sociales 2389 89 23.8 2011201 201 2011-201 IC9 (IC95 314 13,314,7 13314 133 13, 147 14, 13,3-14,7 310 9,310, 9310 93 9, 106 10, 9,3-10, 121 12- 1, 238 8 23. 201120 20 2011-20 (IC9 31 13,314, 1331 13,3-14, 9,310 931 9,3-10 20112 2011-2 (IC 13,314 13,3-14 9,31 9,3-1 2011- 13,31 13,3-1 9,3- 13,3-

Resumo: Estudo transversal, de base hospitalar, nacional, com entrevista de 23.894 puérperas, em 2011-2012, com os objetivos de estimar a prevalência de consumo de álcool na gestação e identificar grupos mais vulneráveis. O uso de álcool na gestação foi identificado por meio da escala TWEAK, sendo classificadas como “diagnóstico presumível de uso inadequado de álcool” mulheres com pontuação ≥ 2. Calculou-se a prevalência nacional de uso de álcool e em subgrupos de acordo com características maternas, com respectivos intervalos de 95% de confiança (IC95%). Foram encontradas, de forma gráfica, coexistência de tabagismo, inadequação de consultas pré-natais e ingestão de bebidas alcoólicas na gestação. A prevalência de uso de álcool foi de 14% (IC95%: 13,3-14,7), com 10% (IC95%: 9,3-10,6) das mulheres apresentando diagnóstico presumível de uso inadequado de álcool na gestação. Maiores prevalências de uso de álcool e de diagnóstico presumível de uso inadequado foram observadas em mulheres pretas, com 12-19 anos de idade, com menor índice de escolaridade, de classe econômica mais baixa, sem companheiro, sem trabalho remunerado, com mais de três partos anteriores, que não queriam engravidar, com assistência pré-natal inadequada, com parto em serviços públicos e que referiram tabagismo na gestação. Estima-se que 1,2% das mulheres entrevistadas apresentavam concomitância dos três fatores de risco para desfechos perinatais negativos: fumo, álcool e assistência pré-natal inadequada. Os resultados demonstraram alta prevalência de uso de álcool na gestação e de diagnóstico presumível de uso inadequado, principalmente por mulheres em situação de vulnerabilidade social. São relevantes a elaboração de políticas públicas que contemplem ações de prevenção do uso de bebidas alcoólicas e a prestação de serviços de apoio para cessação do uso de álcool na gravidez. Resumo transversal hospitalar 23894 23 894 23.89 puérperas 20112012, 20112012 2011 2012, 2012 2011-2012 vulneráveis TWEAK 2 Calculouse Calculou se maternas 95 IC95%. IC95 IC IC95% . (IC95%) encontradas gráfica prénatais pré natais 14 (IC95% 13,314,7, 133147 13,3 14,7 , 13 3 7 13,3-14,7) 10 9,310,6 93106 9,3 10,6 9 6 9,3-10,6 pretas 1219 12 19 12-1 idade escolaridade baixa companheiro remunerado anteriores engravidar prénatal natal inadequada Estimase Estima 1 1,2 negativos fumo social gravidez 2389 89 23.8 2011201 201 2011-201 IC9 (IC95 314 13,314,7 13314 133 13, 147 14, 13,3-14,7 310 9,310, 9310 93 9, 106 10, 9,3-10, 121 12- 1, 238 8 23. 201120 20 2011-20 (IC9 31 13,314, 1331 13,3-14, 9,310 931 9,3-10 20112 2011-2 (IC 13,314 13,3-14 9,31 9,3-1 2011- 13,31 13,3-1 9,3- 13,3-

Abstract: This is a national cross-sectional, hospital-based study, which interviewed 23,894 postpartum women in 2011-2012 aiming to estimate the prevalence of alcohol use during pregnancy and identifying more vulnerable groups. Alcohol use during pregnancy was identified using the TWEAK scale, and women with a score of ≥ 2 were classified as having a “presumable diagnosis of inadequate alcohol use”. The national prevalence of alcohol use and the prevalence in subgroups were calculated according to maternal characteristics, with respective 95% confidence intervals (95%CI). Coexistence of smoking, inadequate prenatal consultations, and alcohol use during pregnancy were graphically identified. The prevalence of alcohol use was 14% (95%CI: 13.3-14.7), with 10% (95%CI: 9.3-10.6) of women presenting presumable diagnosis of inadequate alcohol us during pregnancy. Higher prevalence of alcohol use and presumable diagnosis of inadequate alcohol us was observed in black women, aged 12-19 years, with lower educational level, from a lower economic class, without a partner, without paid work, with more than three previous births, who did not want to get pregnant, with inadequate prenatal care, with previous delivery in public services, and who reported smoking during pregnancy. Among the interviewees, 1.2% presented all three risk factors for negative perinatal outcomes at the same time: smoking, alcohol use, and inadequate prenatal care. The results showed a high prevalence of alcohol use during pregnancy and presumable diagnosis of inadequate alcohol us, especially among women with worse social conditions. These data are relevant for the formulation of public policies to prevent alcohol use and provide support services to help this population stop alcohol use during pregnancy. Abstract crosssectional, crosssectional cross sectional, sectional cross-sectional hospitalbased hospital based study 23894 23 894 23,89 20112012 2011 2012 2011-201 groups scale use. . use” characteristics 95 95%CI. 95CI CI 95%CI (95%CI) consultations 14 (95%CI 13.314.7, 133147 13.3 14.7 , 13 3 7 13.3-14.7) 10 9.310.6 93106 9.3 10.6 9 6 9.3-10.6 1219 12 19 12-1 years level class partner work births pregnant care interviewees 1 1.2 time conditions 2389 89 23,8 2011201 201 2011-20 314 13.314.7 13314 133 13. 147 14. 13.3-14.7 310 9.310. 9310 93 9. 106 10. 9.3-10. 121 12- 1. 238 8 23, 201120 20 2011-2 31 13.314. 1331 13.3-14. 9.310 931 9.3-10 20112 2011- 13.314 13.3-14 9.31 9.3-1 13.31 13.3-1 9.3- 13.3-

https://doi.org/10.1590/0102-311xpt232422

Qualidade de Vida Relacionada à Saúde e Desfechos em Longo Prazo após COVID-19 Sintomática Leve: Protocolo do Estudo Pós-COVID Brasil 2 COVID19 COVID 19 COVID-1 Leve PósCOVID Pós COVID1 1 COVID-
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Rover, Marciane Maria

; Trott, Geraldine

; Scolari, Fernando Luís

; Silva, Mariana Motta Dias da

; Souza, Denise de

; Santos, Rosa da Rosa Minho dos

; Dagnino, Ana Paula Aquistapase

; Mesquita Neto, Juliana de

; Estivalete, Gabriel Pozza

; Kozesinski-Nakatani, Amanda Christina

; Marcolino, Milena Soriano

; Barreto, Bruna Brandão

; Schvartzman, Paulo Roberto

; Antonio, Ana Carolina Peçanha

; Robinson, Caroline Cabral

; Falavigna, Maicon

; Biolo, Andreia

; Polanczyk, Carisi Anne

; Rosa, Regis Goulart

Arquivos Brasileiros de Cardiologia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2023, Volume 120 N. 9 elocation e20220835

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento Os efeitos em longo prazo da COVID-19 leve sobre a saúde física, mental e cognitiva ainda não são bem conhecidos. Objetivo Este artigo visa descrever o protocolo para o estudo em andamento Pós-COVID Brasil 2, o qual tem como objetivo avaliar os fatores associados à qualidade de vida associada à saúde e desfechos cardiovasculares e não cardiovasculares de longo prazo um ano após um episódio de COVID-19 sintomática leve. Métodos O estudo “Pós-COVID Brasil 2” é um estudo multicêntrico prospectivo que pretende incluir 1047 pacientes (NCT05197647). Entrevistas estruturas, centralizadas são conduzidas em um mês, e aos três, seis, nove e 12 meses após o diagnóstico de COVID-19. O desfecho primário é o escore de utilidade da qualidade de vida relacionada à saúde, avaliado usando o questionário EuroQol-5D-3L (EQ-5D-3L) aos 12 meses. Desfechos secundários incluem o EQ-5D-3L aos três, seis e nove meses, mortalidade por todas as causas, eventos cardiovasculares maiores, hospitalização, retorno ao trabalho ou à escola, sintomas persistentes, novas incapacidades em atividades instrumentais diárias, déficit cognitivo, ansiedade, depressão, e sintomas de transtorno do estresse pós-traumático as três, seis, nove e doze meses após a infecção pelo SARS-CoV-2. Um valor de p<0,05 será considerado estatisticamente significativo para as análises. Resultados O desfecho primário será apresentado como frequência dos domínios do EQ-5D-3L doze meses após a infecção por SARS-CoV-2. A análise principal explorará a associação das variáveis independentes com os desfechos do estudo. Conclusão O estudo “Pós-COVID Brasil 2” tem como objetivo elucidar o impacto da COVID longa sobre a qualidade de vida e desfechos cardiovasculares e não cardiovasculares de brasileiros pacientes que apresentaram COVID-19 leve. COVID19 19 COVID-1 física conhecidos PósCOVID Pós 2 104 NCT05197647. NCT05197647 NCT . (NCT05197647) estruturas mês três 1 COVID19. 19. EuroQol5D3L EuroQolDL EuroQol 5D 3L D L EQ5D3L EQDL EQ (EQ-5D-3L causas maiores hospitalização escola persistentes diárias cognitivo ansiedade depressão póstraumático pós traumático SARSCoV2. SARSCoV2 SARSCoV SARS CoV 2. SARS-CoV-2 p005 p 0 05 p<0,0 análises COVID1 COVID- 10 NCT0519764 (NCT05197647 SARS-CoV- p00 p<0, NCT051976 (NCT0519764 SARS-CoV p0 p<0 NCT05197 (NCT051976 p< NCT0519 (NCT05197 NCT051 (NCT0519 NCT05 (NCT051 NCT0 (NCT05 (NCT0 (NCT

Abstract Background The long-term effects of mild COVID-19 on physical, cognitive, and mental health are not yet well understood. Objective The purpose of this paper is to describe the protocol for the ongoing “Post-COVID Brazil” study 2, which aims to evaluate the factors associated with health-related quality of life and long-term cardiovascular and non-cardiovascular outcomes one year after a mild episode of symptomatic COVID-19. Methods The “Post-COVID Brazil” study 2 is a prospective multicenter study that plans to enroll 1047 patients (NCT05197647). Centralized, structured telephone interviews are conducted at 1, 3, 6, 9, and 12 months after COVID-19 diagnosis. The primary outcome is the health-related quality-of-life utility score, assessed using the EuroQol-5D-3L (EQ-5D-3L) questionnaire at 12 months. Secondary endpoints include the EQ-5D-3L at 3, 6, and 9 months, as well as all-cause mortality, major cardiovascular events, hospitalization, return to work or education, persistent symptoms, new disabilities in instrumental activities of daily living, cognitive impairment, anxiety, depression, and post-traumatic stress symptoms at 3, 6, 9, and 12 months after SARS-CoV-2 infection. A p-value < 0.05 will be considered statistically significant for all analyses. Results The primary endpoint will be presented as the overall frequency of the EQ-5D-3L domains 12 months after SARS-CoV-2 infection. Main analysis will explore the association of independent variables with the study outcomes. Conclusion The “Post-COVID Brazil” study 2 aims to clarify the impact of long COVID on the quality of life and cardiovascular and non-cardiovascular outcomes of Brazilian patients who have had mild COVID-19. longterm term COVID19 19 COVID-1 physical understood PostCOVID Post Brazil healthrelated related noncardiovascular non COVID19. 19. 104 NCT05197647. NCT05197647 NCT . (NCT05197647) Centralized 1 3 6 diagnosis qualityoflife score EuroQol5D3L EuroQolDL EuroQol 5D 3L D L EQ5D3L EQDL EQ (EQ-5D-3L allcause cause mortality events hospitalization education living impairment anxiety depression posttraumatic post traumatic SARSCoV2 SARSCoV SARS CoV SARS-CoV- infection pvalue p value 005 0 05 0.0 analyses COVID1 COVID- 10 NCT0519764 (NCT05197647 SARS-CoV 00 0. NCT051976 (NCT0519764 NCT05197 (NCT051976 NCT0519 (NCT05197 NCT051 (NCT0519 NCT05 (NCT051 NCT0 (NCT05 (NCT0 (NCT

https://doi.org/10.36660/abc.20220835

Qualidade de Vida em Longo Prazo e Desfechos após Internação por COVID-19 no Brasil: Protocolo do Estudo Pós-COVID Brasil 1 COVID19 COVID 19 COVID-1 PósCOVID Pós COVID1 COVID-
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Trott, Geraldine

; Scolari, Fernando Luis

; Rover, Marciane Maria

; Silva, Mariana Motta Dias da

; Souza, Denise de

; Santos, Rosa da Rosa Minho dos

; Schardosim, Raíne Fogliati de Carli

; Rech, Gabriela Soares

; Mesquita Neto, Juliana de

; Estivalete, Gabriel Pozza

; Freitas, Hellen Jordan Martins

; Itaqui, Carolina Rothmann

; Kozesinski-Nakatani, Amanda Christina

; Biolo, Andreia

; Marcolino, Milena Soriano

; Barreto, Bruna Brandão

; Schvartzman, Paulo Roberto

; Antonio, Ana Carolina Peçanha

; Robinson, Caroline Cabral

; Falavigna, Maicon

; Polanczyk, Carisi Anne

; Rosa, Regis Goulart

Arquivos Brasileiros de Cardiologia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2023, Volume 120 N. 11 elocation e20230378

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento O impacto em longo prazo da hospitalização por COVID-19 sobre a saúde física, mental e cognitiva dos pacientes requer mais investigação. Objetivos Este artigo visa avaliar os fatores associados com a qualidade de vida e desfechos cardiovasculares e não cardiovasculares 12 meses após a internação hospitalar por COVID-19. Métodos Este estudo multicêntrico prospectivo pretende incluir 611 pacientes internados por COVID-19 (NCT05165979). Entrevistas telefônicas centralizadas estão programadas para ocorrer em três, seis, nove e 12 meses após a alta hospitalar. O desfecho primário é definido como o escore de utilidade de qualidade de vida relacionada à saúde avaliada pelo questionário EuroQol-5D-3L (EQ-5D-3L) aos 12 meses. Desfechos secundários são definidos como o EQ-5D-3L aos três, seis e nove meses, retorno ao trabalho ou à escola, sintomas persistentes, novas incapacidades em atividades instrumentais diárias, déficit cognitivo, ansiedade, depressão, e sintomas de transtorno do estresse pós-traumático, eventos cardiovasculares maiores, reinternação, e mortalidade por todas as causas aos três, seis, nove e 12 meses após a infecção pelo SARS-CoV-2. Um valor de p<0,05 será considerado estatisticamente significativo para as análises. Resultados O desfecho primário será apresentado como frequência do escore EQ-5D-3L 12 meses após a internação por COVID-19. Uma subanálise para identificar possíveis associações das variáveis independentes com desfechos do estudo será apresentada. Conclusão Este estudo determinará o impacto da COVID-19 sobre a qualidade de vida e de desfechos cardiovasculares e não cardiovasculares de pacientes internados 12 meses após a alta, e fornecerá novas informações ao sistema público de saúde no Brasil. COVID19 COVID 19 COVID-1 física investigação 1 COVID19. 19. 61 NCT05165979. NCT05165979 NCT . (NCT05165979) três EuroQol5D3L EuroQolDL EuroQol 5D 3L D L EQ5D3L EQDL EQ (EQ-5D-3L escola persistentes diárias cognitivo ansiedade depressão póstraumático, póstraumático pós traumático, traumático pós-traumático maiores reinternação SARSCoV2. SARSCoV2 SARSCoV SARS CoV 2. 2 SARS-CoV-2 p005 p 0 05 p<0,0 análises apresentada Brasil COVID1 COVID- 6 NCT0516597 (NCT05165979 SARS-CoV- p00 p<0, NCT051659 (NCT0516597 SARS-CoV p0 p<0 NCT05165 (NCT051659 p< NCT0516 (NCT05165 NCT051 (NCT0516 NCT05 (NCT051 NCT0 (NCT05 (NCT0 (NCT

Abstract Background The long-term impact of hospitalization for COVID-19 on patients’ physical, mental, and cognitive health still needs further assessment. Objectives This study aims to evaluate factors associated with quality of life and cardiovascular and non-cardiovascular outcomes 12 months after hospitalization for COVID-19. Methods This prospective multicenter study intends to enroll 611 patients hospitalized due to COVID-19 (NCT05165979). Centralized telephone interviews are scheduled to occur at three, six, nine, and 12 months after hospital discharge. The primary endpoint is defined as the health-related quality-of-life utility score assessed by the EuroQol-5D-3L (EQ-5D-3L) questionnaire at 12 months. Secondary endpoints are defined as the EQ-5D-3L at three, six and nine months, return to work or education, persistent symptoms, new disabilities in instrumental activities of daily living, cognitive impairment, anxiety, depression, and post-traumatic stress symptoms, major cardiovascular events, rehospitalization, as well as all-cause mortality at 3, 6, 9, and 12 months after SARS-CoV-2 infection. A p-value <0.05 will be assumed as statistically significant for all analyses. Results The primary endpoint will be presented as the frequency of the EQ-5D-3L score 12 months after COVID-19 hospitalization. A sub-analysis to identify possible associations of independent variables with study outcomes will be presented. Conclusions This study will determine the impact of COVID-19 on the quality of life and cardiovascular and non-cardiovascular outcomes of hospitalized patients 12 months after discharge providing insights to the public health system in Brazil. longterm long term COVID19 COVID 19 COVID-1 physical mental assessment noncardiovascular non 1 COVID19. 19. 61 NCT05165979. NCT05165979 NCT . (NCT05165979) three healthrelated related qualityoflife EuroQol5D3L EuroQolDL EuroQol 5D 3L D L EQ5D3L EQDL EQ (EQ-5D-3L education symptoms living impairment anxiety depression posttraumatic post traumatic events rehospitalization allcause cause 3 6 9 SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- infection pvalue p value 005 0 05 <0.0 analyses subanalysis sub analysis Brazil COVID1 COVID- NCT0516597 (NCT05165979 SARS-CoV 00 <0. NCT051659 (NCT0516597 <0 NCT05165 (NCT051659 < NCT0516 (NCT05165 NCT051 (NCT0516 NCT05 (NCT051 NCT0 (NCT05 (NCT0 (NCT

https://doi.org/10.36660/abc.20230378

10.

Prevalência de uso de álcool na gestação, Brasil, 2011-2012
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Cabral, Vanderlea Poeys

; Moraes, Claudia Leite de

; Bastos, Francisco I.

; Abreu, Angela Maria Mendes

; Domingues, Rosa Maria Soares Madeira

Cadernos de Saúde Pública

Journal Metrics
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2023, Volume 39 N. 8 elocation e00232422

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

https://doi.org/10.1590/0102-311xpt232422

11.

Botulism in the Brazilian Amazon: a life-threatening disease in a neglected population Amazon lifethreatening life threatening
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Oliveira, Louise Makarem

; Gonçalves, Daniel Buzaglo

; Cabral, Lucas de Cristo Rojas

; Bernardino, Marília Rosa Abtibol

; Feitoza, Pablo Vinícius Silveira

Arquivos de Neuro-Psiquiatria

Journal Metrics
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dec 2022, Volume 80 N. 12 Pages 1227 - 1232

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Antecedentes O botulismo é uma síndrome neuroparalítica rara e potencialmente fatal causada pela bactéria anaeróbia gram-positiva formadora de esporosClostridium botulinum. O microrganismo produz uma neurotoxina que inibe a liberação pré-sináptica de acetilcolina na junção neuromuscular, levando clinicamente a uma síndrome miastênica. Objetivo Descrever o recente surto de casos de botulismo e suas características demográficas, clínicas e laboratoriais. Métodos Relatamos quatro pacientes com botulismo em surto recente ocorrido entre 2017 e 2019 no estado do Amazonas. Resultados Dos quatro pacientes com botulismo, três o contraíram devido ao consumo de alimento contaminado e um por ferimento. Enfatizamos o excelente resultado clínico das diferentes apresentações da doença em nossa série de casos. Conclusão A proximidade temporal dessas notificações pode sugerir um novo aumento no número de casos nos próximos anos. Uma possível hipótese é que a raridade da doença diminuiu a conscientização quanto à prevenção primária ou mesmo ao diagnóstico por médico destreinado. grampositiva gram positiva botulinum présináptica pré sináptica neuromuscular miastênica demográficas laboratoriais 201 Amazonas ferimento anos destreinado 20 2

Abstract Background Botulism is a rare and potentially fatal neuroparalytic syndrome caused by the gram-positive anaerobe spore-forming bacteriumClostridium botulinum. The microorganism produces a neurotoxin that inhibits the presynaptic release of acetylcholine at the neuromuscular junction, clinically leading to a myasthenic syndrome. Objective To describe the recent outbreak of botulism cases and its demographic, clinical, and laboratory characteristics. Methods We report 4 patients with botulism in the recent outbreak occurred between 2017 and 2019 in the state of Amazon. Results Out of four patients with botulism, three contracted it from eating contaminated food and one had wound botulism. We emphasize the excellent clinical outcome of the different disease presentations in our case series. Conclusion The temporal proximity of these reports may suggest a new rise in the number of cases in the upcoming years. A possible hypothesis is that the rarity of the disease decreased the awareness regarding the primary prevention or even a diagnosis by an untrained physician. grampositive gram positive sporeforming spore forming botulinum junction demographic characteristics 201 Amazon series years physician 20 2

https://doi.org/10.1055/s-0042-1758651

12.

O que mudou entre os períodos de pico e de platô durante a primeira onda do SARS-CoV-2? Estudo multicêntrico português em unidades de cuidados intensivos SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV-2 SARS-CoV- SARS-CoV
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Pereira, Rui Antunes

; Sousa, Marta

; Cidade, José Pedro

; Melo, Luís

; Lopes, Diogo

; Ventura, Sara

; Aragão, Irene

; Lima Neto, Raul Miguel de Freitas

; Molinos, Elena

; Marques, Ana

; Cardoso, Nelson

; Marino, Flávio

; Monteiro, Filipa Brás

; Oliveira, Ana Pinho

; Silva, Rogério C

; Real, André Miguel Neto

; Banheiro, Bruno Sarmento

; Reis, Renato

; Adão-Serrano, Maria

; Cracium, Ana

; Valadas, Ana

; Ribeiro, João Miguel

; Póvoa, Pedro

; Tapadinhas, Camila

; Mendes, Vítor

; Coelho, Luís

; Maia, Raquel

; Freitas, Paulo Telles

; Ferreira, Isabel Amorim

; Ramires, Tiago

; Val-Flores, Luís Silva

; Cascão, Mariana

; Alves, Rita

; Rodeia, Simão C

; Barrigoto, Cleide

; Cardiga, Rosa

; Silva, Maria João Ferreira da

; Vale, Bruno

; Fonseca, Tatiana

; Rios, Ana Lúcia

; Camões, João

; Pérez, Danay

; Cabral, Susana

; Ribeiro, Maria Inês

; Mendes, João João

; Gouveia, João

; Fernandes, Susana Mendes

Revista Brasileira de Terapia Intensiva

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dec 2022, Volume 34 N. 4 Pages 433 - 442

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Analisar e comparar as características de pacientes críticos com a COVID-19, a abordagem clínica e os resultados entre os períodos de pico e de platô na primeira onda pandêmica em Portugal. Métodos: Este foi um estudo de coorte multicêntrico ambispectivo, que incluiu pacientes consecutivos com a forma grave da COVID-19 entre março e agosto de 2020 de 16 unidades de terapia intensiva portuguesas. Definiram-se as semanas 10 - 16 e 17 - 34 como os períodos de pico e platô. Resultados: Incluíram-se 541 pacientes adultos com mediana de idade de 65 [57 - 74] anos, a maioria do sexo masculino (71,2%). Não houve diferenças significativas na mediana de idade (p = 0,3), no Simplified Acute Physiology Score II (40 versus 39; p = 0,8), na pressão parcial de oxigênio/fração inspirada de oxigênio (139 versus 136; p = 0,6), na terapia com antibióticos na admissão (57% versus 64%; p = 0,2) ou na mortalidade aos 28 dias (24,4% versus 22,8%; p = 0,7) entre o período de pico e platô. Durante o período de pico, os pacientes tiveram menos comorbidades (1 [0 - 3] versus 2 [0 - 5]; p = 0,002); fizeram mais uso de vasopressores (47% versus 36%; p < 0,001) e ventilação mecânica invasiva na admissão (58,1% versus 49,2%; p < 0,001), e tiveram mais prescrição de hidroxicloroquina (59% versus 10%; p < 0,001), lopinavir/ritonavir (41% versus 10%; p < 0,001) e posição prona (45% versus 36%; p = 0,04). Entretanto, durante o platô, observou-se maior uso de cânulas nasais de alto fluxo (5% versus 16%; p < 0,001) na admissão, remdesivir (0,3% versus 15%; p < 0,001) e corticosteroides (29% versus 52%; p < 0,001), além de menor tempo de internação na unidade de terapia intensiva (12 versus 8 dias; p < 0,001). Conclusão: Houve mudanças significativas nas comorbidades dos pacientes, nos tratamentos da unidade de terapia intensiva e no tempo de internação entre os períodos de pico e platô na primeira onda da COVID-19. Objetivo COVID19, COVID19 COVID 19, 19 Portugal Métodos ambispectivo COVID-1 202 1 portuguesas Definiramse Definiram se 3 Resultados Incluíramse Incluíram 54 6 57 [5 74 anos 71,2%. 712 71,2% . 71 (71,2%) 0,3, 03 0,3 , 0 0,3) 40 (4 39 0,8, 08 0,8 0,8) oxigêniofração fração 139 (13 136 0,6, 06 0,6 0,6) 57% (57 64% 64 0,2 02 24,4% 244 24 4 (24,4 22,8% 228 22 0,7 07 7 ( [ 5 5] 0,002 0002 002 0,002) 47% 47 (47 36% 36 0,001 0001 001 58,1% 581 58 (58,1 49,2% 492 49 0,001, 59% 59 (59 10% lopinavirritonavir lopinavir ritonavir 41% 41 (41 45% 45 (45 0,04. 004 0,04 04 0,04) Entretanto observouse observou 5% (5 16% 0,3% (0,3 15% 15 29% 29 (29 52% 52 12 0,001. Conclusão COVID19. 19. COVID1 COVID- 20 71,2 (71,2% 0, 13 24,4 (24, 22,8 0,00 000 00 58,1 (58, 49,2 0,0 (0, (2 71, (71,2 24, (24 22, 58, (58 49, (0 (71, (71 (7

ABSTRACT Objective: To analyze and compare COVID-19 patient characteristics, clinical management and outcomes between the peak and plateau periods of the first pandemic wave in Portugal. Methods: This was a multicentric ambispective cohort study including consecutive severe COVID-19 patients between March and August 2020 from 16 Portuguese intensive care units. The peak and plateau periods, respectively, weeks 10 - 16 and 17 - 34, were defined. Results: Five hundred forty-one adult patients with a median age of 65 [57 - 74] years, mostly male (71.2%), were included. There were no significant differences in median age (p = 0.3), Simplified Acute Physiology Score II (40 versus 39; p = 0.8), partial arterial oxygen pressure/fraction of inspired oxygen ratio (139 versus 136; p = 0.6), antibiotic therapy (57% versus 64%; p = 0.2) at admission, or 28-day mortality (24.4% versus 22.8%; p = 0.7) between the peak and plateau periods. During the peak period, patients had fewer comorbidities (1 [0 - 3] versus 2 [0 - 5]; p = 0.002) and presented a higher use of vasopressors (47% versus 36%; p < 0.001) and invasive mechanical ventilation (58.1 versus 49.2%; p < 0.001) at admission, prone positioning (45% versus 36%; p = 0.04), and hydroxychloroquine (59% versus 10%; p < 0.001) and lopinavir/ritonavir (41% versus 10%; p < 0.001) prescriptions. However, a greater use of high-flow nasal cannulas (5% versus 16%, p < 0.001) on admission, remdesivir (0.3% versus 15%; p < 0.001) and corticosteroid (29% versus 52%, p < 0.001) therapy, and a shorter ICU length of stay (12 days versus 8, p < 0.001) were observed during the plateau. Conclusion: There were significant changes in patient comorbidities, intensive care unit therapies and length of stay between the peak and plateau periods of the first COVID-19 wave. Objective COVID19 COVID 19 COVID-1 characteristics Portugal Methods 202 1 units respectively 34 defined Results fortyone forty one 6 57 [5 74 years 71.2%, 712 71.2% , 71 (71.2%) included 0.3, 03 0.3 0 3 0.3) 40 (4 39 0.8, 08 0.8 8 0.8) pressurefraction pressure fraction 139 (13 136 0.6, 06 0.6 0.6) 57% (57 64% 64 0.2 02 admission 28day day 28 24.4% 244 24 4 (24.4 22.8% 228 22 0.7 07 7 period ( [ 5 5] 0.002 0002 002 47% 47 (47 36% 36 0.001 0001 001 58.1 581 58 (58. 49.2% 492 49 45% 45 (45 0.04, 004 0.04 04 0.04) 59% 59 (59 10% lopinavirritonavir lopinavir ritonavir 41% 41 (41 prescriptions However highflow high flow 5% (5 16% 0.3% (0.3 15% 15 29% 29 (29 52 52% 12 Conclusion COVID1 COVID- 20 71.2 (71.2% 0. 13 24.4 (24. 22.8 0.00 000 00 58. (58 49.2 0.0 (0. (2 71. (71.2 24. (24 22. 49. (0 (71. (71 (7

https://doi.org/10.5935/0103-507x.20210037-pt

13.

[SciELO Preprints] - Cancer surveillance in Mato Grosso: methodological and operational aspects of a extension/research projects
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Galvão, Noemi Dreyer Souza, Rita Adriana Gomes de Souza, Bárbara da Silva Nalin de Melanda, Francine Nesello Andrade, Amanda Cristina de Souza Sousa, Neuciani Ferreira da Silva Correa, Márcia Leopoldina Montanari Silva, Ageo Mario Candido da Neves, Marco Aurélio Bertúlio das Oliveira, Jânia Cristiane de Souza Cabral, Juliana Fernandes Soares, Mariana Rosa Souza, Paulo Cesar Fernandes de Alves, Mário Ribeiro Barbosa, Jackson Rogerio Pignati , Wanderlei Antonio

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Publication date: 2022-04-25

Abstract: En Pt

Objective: To describe the methodological and operational aspects of the Cancer Surveillance Project and its associated factors: population-based and hospital-based registry (VIGICAN), in Mato Grosso (MT). Methods: VIGICAN was divided into two projects: an extension one, which updated the data from the Population-Based Cancer Registry (RCBP) of MT in the period 2008 to 2016; and one of research, which collected primary data, through individual interviews and analysis of medical records of people with a diagnosis of cancer, aged 18 years or over, treated at reference hospitals for oncology. To analyze the factors associated with cancer, the following variables were collected: socioeconomic and demographic, social support, status and health behavior, and environmental exposure. Results: In the períod from 2008 to 2016, approximately one hundred thousand cases of cancer (incident and prevalent) were reported in the RCBP Cuiabá and Interior. After validation procedures, fifty thousand incident cases were chosen. The survey interviewed 1,012 patients, 38.2% living in the municipalities of Cuiabá and Várzea Grande, 60.4% in the interior of the state and 1.4% in other states. Preliminary data revealed that the majority were female (55.0%) and younger than 60 years (54.3%). Among those interviewed, 7.2% reported smoking tobacco, 15.5% consumed alcoholic beverages (15.5%) and 32.7% lived close to crops. Conclusion: The development of these projects allowed the integration of education with health services and will enable the recognition of specificities and different exposure scenarios and factors associated with cancer in the Mato Grosso territory.

Objetivo: Descrever os aspectos metodológicos e operacionais do Projeto Vigilância do Câncer e seus fatores associados: registro de base populacional e hospitalar (VIGICAN), em Mato Grosso (MT). Métodos: O VIGICAN se desdobrou em dois projetos: um de extensão, que atualizou os dados dos Registros de Câncer de Base Populacional (RCBP) de MT no período de 2008 a 2016; e um de pesquisa, que coletou dados primários, por meio de entrevistas individuais e análise de prontuários de pessoas com diagnóstico de câncer, com 18 anos ou mais, atendidas em hospitais de referência para oncologia. Para analisar os fatores associados ao câncer, foram coletadas as seguintes variáveis: socioeconômicas e demográficas, suporte social, situação e comportamentos de saúde e exposição ambiental. Resultados: No período de 2008 a 2016, foram notificados nos RCBP Cuiabá e Interior, aproximadamente, 100 mil casos de câncer (incidentes e prevalentes). Após procedimentos de validação, foram eleitos 50 mil casos incidentes. A pesquisa entrevistou 1.012 pacientes, sendo 38,2% residentes nos municípios de Cuiabá e Várzea Grande, 60,4% no interior do estado e 1,4% em outros estados. Os dados preliminares revelaram que a maioria era do sexo feminino (55,0%) e tinha menos de 60 anos (54,3%). Entre os entrevistados, 7,2% relataram fumar tabaco, 15,5% consumiam bebidas alcoólicas (15,5%) e 32,7% moravam próximos a lavouras. Conclusão: O desenvolvimento desses projetos permitiu a integração do ensino com os serviços de saúde e possibilitará o reconhecimento das especificidades e diferentes cenários de exposição e fatores associados ao câncer do território mato-grossense.

https://doi.org/10.1590/1980-549720220002.supl.1.1

14.

Fungal metalloprotease generate whey-derived peptides that may be involved in apoptosis in B16F10 melanoma cells
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HAMIN NETO, Youssef Ali Abou

; GARZON, Nathália Gonsales da Rosa

; COITINHO, Luciana Barbosa

; SOBRAL, Lays Martin

; LEOPOLDINO, Andréia Machado

; CATALDI, Thaís Regiani

; LABATE, Carlos Alberto

; CABRAL, Hamilton

Food Science and Technology

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2022, Volume 42 elocation e43022

Abstract: En | Text: En | PDF: En

Abstract Proteases are enzymes that act in the hydrolysis of proteins and have several industrial applications. Moreover, proteases have gained prominence as enzymes for the generation of bioactive peptides from the hydrolysis of different protein sources. Milk is the most studied protein source to obtain peptides due to its nutritional and physiological effects and has been studied as complementary therapeutic approaches for the cancer treatment, interacting specifically with cancer cells, consequently fewer side effects. The ability of Eupenicillium javanicum metalloprotease to generate whey-derived peptides with antioxidant activity has already been demonstrated. For this reason, we thus hypothesized that whey-derived peptides from Eupenicillium javanicum metalloprotease hydrolysis could also have a potential against melanoma cell lines. In this study, B16F10 melanoma cells were treated for 72 h with whey-derived peptides and the effects on cell viability were determined. Moreover, the protein profiles of the treated and nontreated cells were compared in proteomic assay and mass spectrometry analyzes. Whey-derived peptides impaired about 62% cell viability, and proteomic approach associated this behavior to modulate proteins involved in proliferation, energy, apoptosis, metastatic and malignancy rates. This study describes the relevance of microbial enzymes in generation of whey-derived peptides with biological activity against melanoma cells.

https://doi.org/10.1590/fst.43022

15.

Cancer surveillance in Mato Grosso, Brazil: methodological and operational aspects of a university extension/research project
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Galvão, Noemi Dreyer

; Souza, Rita Adriana Gomes de

; Souza, Bárbara da Silva Nalin de

; Melanda, Francine Nesello

; Andrade, Amanda Cristina de Souza

; Sousa, Neuciani Ferreira da Silva

; Correa, Márcia Leopoldina Montanari

; Silva, Ageo Mario Candido da

; Neves, Marco Aurélio Bertúlio das

; Oliveira, Jânia Cristiane de Souza

; Cabral, Juliana Fernandes

; Soares, Mariana Rosa

; Souza, Paulo Cesar Fernandes de

; Alves, Mário Ribeiro

; Barbosa, Jackson Rogerio

; Pignati, Wanderlei Antonio

Revista Brasileira de Epidemiologia

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2022, Volume 25 Suppl. 1 elocation e220002

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Objetivo: Descrever os aspectos metodológicos e operacionais do projeto "Vigilância do câncer e seus fatores associados: registro de base populacional e hospitalar" (VIGICAN), em Mato Grosso (MT). Métodos: O VIGICAN desdobrou-se em dois projetos: um de extensão, que atualizou os dados dos Registros de Câncer de Base Populacional (RCBP) de Mato Grosso no período de 2008 a 2016; e um de pesquisa, que coletou dados primários por meio de entrevistas individuais e análise de prontuários de pessoas com diagnóstico de câncer, com 18 anos ou mais, atendidas em hospitais de referência para oncologia. Para analisar os fatores associados ao câncer, foram coletadas as seguintes variáveis: socioeconômicas e demográficas, suporte social, situação e comportamentos de saúde e exposição ambiental. Resultados: No período de 2008 a 2016, foram notificados nos RCBP Cuiabá e Interior, aproximadamente, 100 mil casos de câncer (incidentes e prevalentes). Após os procedimentos de validação, foram eleitos 50 mil casos incidentes. A pesquisa entrevistou 1.012 pacientes, sendo 38,2% residentes nos municípios de Cuiabá e Várzea Grande, 60,4% no interior do Estado e 1,4% em outros Estados. Os dados preliminares revelaram que a maioria era do sexo feminino (55,0%) e tinha menos de 60 anos (54,3%). Entre os entrevistados, 7,2% relataram fumar tabaco, 15,5% consumiam bebidas alcoólicas (15,5%) e 32,7% moravam próximo a lavouras. Conclusão: O desenvolvimento desses projetos permitiu a integração do ensino com os serviços de saúde e possibilitará o reconhecimento das especificidades e dos diferentes cenários de exposição ao câncer, bem como fatores associados a ele, no território mato-grossense.

ABSTRACT: Objective: To describe the methodological and operational aspects of the "Project for surveillance of cancer and its associated factors: population-based and hospital-based registry" (VIGICAN), in the state of Mato Grosso (MT), Brazil. Methods: VIGICAN was divided into two projects: a university extension one, which updated the data from the Population-based Cancer Registry (PBCR) of MT in the 2008-2016 period; and a research project, which collected primary data, through individual interviews and analysis of medical records of people with a diagnosis of cancer, aged 18 years or older, treated at reference hospitals for oncology. To analyze the factors associated with cancer, the following variables were collected: socioeconomic and demographic, social support, health status and behavior, and environmental exposure. Results: In the 2008-2016 period, approximately one hundred thousand cases of cancer (incident and prevalent) were reported in the PBCR Cuiabá and PBCR Interior. After validation procedures, 50 thousand incident cases were elected. The survey interviewed 1,012 patients, 38.2% living in the municipalities of Cuiabá and Várzea Grande, 60.4% in small cities of the state, and 1.4% in other states. Preliminary data showed that the majority were women (55.0%) and younger than 60 years of age (54.3%). Among the interviewees, 7.2% reported smoking tobacco, 15.5% consumed alcoholic beverages (15.5%), and 32.7% lived nearby crops. Conclusion: The development of these projects allowed the integration of education with health services and will enable the recognition of specificities and different exposure scenarios and factors associated with cancer in the Mato Grosso territory.

https://doi.org/10.1590/1980-549720220002.supl.1

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