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Características clínicas, bioquímicas y radiológicas en niñas con pubertad precoz central atendidas en un hospital público de Lima
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Cabello-Sánchez, Almendra

; Salinas-Barreto, Sergio

; Loza-Munarriz, Cesar

; Cabello-Morales, Emilio

Revista Medica Herediana

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jan 2024, Volume 35 N. 1 Pages 15 - 22

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN Objetivo Describir las características clínicas, bioquímicas y radiológicas en niñas con pubertad precoz central (PPC) atendidas en un hospital público de Lima. Material y métodos Estudio tipo serie de casos. Se revisaron historias clínicas de niñas con diagnóstico de PPC. Se excluyeron niñas con pubertad precoz periférica (PPP), telarquia aislada y malformaciones. Se calculó el Z-IMC, Z-talla genética, Z-talla y proyección de talla final adulta (PFTA). Se utilizó t-Student, t-test, Wilcoxon y Shapiro-Wilk, mediante el software STATA versión 17. Se consideró estadísticamente significativo p<0,05. El estudio fue aprobado por el CIE de la UPCH y del HCH. Resultados: Se revisaron 86 historias. La edad media cronológica fue 8,16±1,09años y la edad media ósea fue 10,33±1,27años (p≤0,001) entre las medias de la edad ósea y la edad cronológica, el Z-talla de la niña y el Z-talla genética asimismo la PTFA y la talla genética (TG). Se encontró M2(19,7%), M3(59,3%) y M4(20,9%). Normopeso (27,9%), sobrepeso (30,2%) y obesidad (41,8%). La mediana de LH fue 0,6 (RIQ:0,4-1,8) y FSH fue 3,4 (RIQ:2,1-5,2) Conclusión La edad cronológica al diagnóstico fue tardía con una edad ósea significativamente mayor respecto a la cronológica. La talla de la niña respecto a su TG fue significativamente mayor. La PTFA fue significativamente menor que la TG. La mayoría presentó desarrollo mamario avanzado, sobrepeso y obesidad.

SUMMARY Objective To describe the clinical, biochemical, and radiologic findings of girls with early puberty (EP) attended at a public hospital in Lima, Peru. Methods This is a case series study that results from the review of clinical charts of girls diagnosed of (EP). Patients with peripheral EP, isolated thelarche and malformations were excluded. The Z-IMC, Z-genetic height, Z-height, and projected adult final height (PAFH) were calculated. The t-Student, Wilcoxon and Shapiro-Wilk tests were calculated using STATA version 17, a p values < 0.05 was considered statistically significant, the study was approved by the IRB of UPCH and HCH. Results We reviewed 86 charts; mean age was 8,16±1.09 years and mean bone age was 10.33±1.27 years (p≤0.001). We found M2(19.7%), M3(59.3%) and M4(20.9%). Normal weight (27.9%), overweight (30.2%) and obesity (41.8%). Median LH was 0.6 (RIQ:0.4-1.8) and median FSH was 3.4 (RIQ:2.1-5.2). Conclusion Chronologic age at diagnosis was late with a bone age higher than chronologic age. Height of girls compared to genetic height was higher. PAFH was lower than genetic height. Most of the girls presented with advanced breast development, overweight and obesity.

https://doi.org/10.20453/rmh.v35i1.5294

The COVID-19 Pandemic Impact on Breast Cancer Diagnosis: A Retrospective Study
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Negrao, Erika Marina Solla

; Cabello, Cesar

; Conz, Livia

; Mauad, Edmundo Carvalho

; Zeferino, Luiz Carlos

; Vale, Diama Bhadra

Revista Brasileira de Ginecologia e Obstetrícia

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sep 2022, Volume 44 N. 9 Pages 871 - 877

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Este estudo teve como objetivo avaliar o perfil diagnóstico dos casos de câncer de mama na pandemia de coronavirus disease 2019 (COVID-19) em comparação com o ano anterior. Métodos Este é um estudo retrospectivo de casos diagnosticados em um serviço de referência da rede pública de saúde de Campinas, SP, Brasil. Foram analisados dois períodos: de março a outubro de 2019 (período pré-COVID) e de março a outubro de 2020 (período COVID). Todas as mulheres diagnosticadas durante os períodos foram incluídas. Foram utilizados os testes do qui-quadrado ou exato de Fisher e Mann-Whitney. Resultados Nos períodos pré-COVID e COVID, o câncer de mama foi diagnosticado, respectivamente, em 115 e 59 mulheres, e a média de idade no diagnóstico foi de 55 e 57 anos (p = 0,339). No período COVID, foram mais frequentes a história familiar de câncer de mama (9,6% vs 29,8%, p < 0,001), casos sintomáticos (50,4% vs 79,7%, p < 0,001) e com massas palpáveis (56,5% vs 79,7%, p = 0,003). Nas mulheres sintomáticas, a média de dias desde os sintomas até a mamografia foi de 233,6 (458,3) no pré-COVID e 152,1 (151,5) no COVID (p = 0,871). Entre os tumores invasivos no período COVID, a proporção de cânceres nos estágios I e II foi ligeiramente maior, porém não significativa (76,7% vs 82,4%, p = 0,428). Ainda no período COVID, a frequência de tumores tipo luminal A-like foi menor (29,2% vs 11,8%, p = 0,018), de tumores triplo-negativos foi duas vezes maior (10,1% vs 21,6%, p = 0,062), e de tumores positivos para receptor de estrogênio foi inferior (82,2% vs 66,0%, p = 0,030). Conclusão Durante a pandemia de COVID-19, houve uma redução no diagnóstico de câncer de mama. Os casos detectados eram sugestivos de pior prognóstico: mulheres sintomáticas com massas palpáveis e subtipos mais agressivos. Os tumores indolentes foram os mais sensíveis à interrupção do rastreamento.

Abstract Objective This study aimed to evaluate the diagnostic profile of breast cancer cases during the coronavirus disease 2019 (COVID-19) pandemic compared with the previous year. Methods It is a retrospective study of cases diagnosed by a reference service in the public health system of Campinas, SP, Brazil. Two periods were analyzed: March to October 2019 (preCOVID period) and March to October 2020 (COVID-period). All women diagnosed during the periods were included. The Chi-Squared or Fisher exact and Mann-Whitney tests were used. Results In the preCOVID and COVID periods, breast cancers were diagnosed, respectively, in 115 vs 59 women, and the mean ages at diagnosis were 55 and 57 years (p = 0.339). In the COVID period, the family history of breast cancer was more observed (9.6% vs 29.8%, p < 0.001), cases were more frequently symptomatic (50.4% vs 79.7%, p < 0.001) and had more frequently palpable masses (56.5% vs 79.7%, p = 0.003). In symptomatic women, the mean number of days from symptom to mammography were 233.6 (458.3) in 2019 and 152.1 (151.5) in 2020 (p = 0.871). Among invasive tumors, the proportion of breast cancers in stages I and II was slightly higher in the COVID period, although not significantly (76.7% vs 82.4%, p = 0.428). Also in the COVID period, the frequency of luminal A-like tumors was lower (29.2% vs 11.8%, p = 0.018), of triple-negative tumors was twice as high (10.1% vs 21.6%, p = 0.062), and of estrogen receptor-positive tumors was lower (82.2% vs 66.0%, p = 0.030). Conclusion During the COVID-19 pandemic, breast cancer diagnoses were reduced. Cases detected were suggestive of a worse prognosis: symptomatic women with palpable masses and more aggressive subtypes. Indolent tumors were those more sensitive to the interruption in screening.

https://doi.org/10.1055/s-0042-1749207

MOVILIDAD SOCIAL INTERGENERACIONAL EN ESTUDIANTES UNIVERSITARIOS MAPUCHE DE LA ARAUCANÍA
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Tereucán Angulo, Julio César

; Briceño Olivera, Claudio

; Galván Cabello, Miguel

Diálogo andino

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mar 2022, N. 67 Pages 148 - 157

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract The article aims to analyze the perception of intergenerational social mobility of Mapuche university students, based on the construc tion of a typology of future projections in relation to the variables of social origin and parents' education. Sample was composed by 200 students between 18 - 28 years (M = 21.32; SD = 2.75), of which 63.5% were women and 36.5% were men. Two- step cluster analyses was the method of the study, which is recommended for categorical data. The analyses suggested to hold back a five cluster model with a good (.7) cluster quality, based on Kaufman and Rousseeuw works (1990). The sample was analysed according to the obtained clusters, for describe sociodemographic characteristics. Results indicated that the origin social class, parents' education and rurality are determinant factors in the social mobility perception. It is concluded that the access to higher education, it is not a determinant factor in the social mobility perception of mapuche university students, and in the case of students who perceive it, is an intra-class mobility.

Resumen Este artículo tiene como objetivo analizar la percepción de movilidad social intergeneracional de estudiantes universitarios mapuche, a partir de la construcción de una tipología de proyecciones futuras con relación a las variables origen social y educacional de sus padres. La muestra estuvo conformada por 200 estudiantes, entre 18 y 28 años (M= 21.32 años; DT = 2.75), de los cuales el 63.5% fueron mujeres y el 36.5% hombres. El método utilizado fue el análisis de clúster bietápico, el cual es recomendado para variables categóricas. El análisis sugirió retener un modelo de cinco conglomerados de calidad buena (.7), según el criterio establecido por Kaufman y Rousseeuw (1990). La muestra fue analizada a partir de los conglomerados obtenidos, para describir sus características según variables sociodemográficas de interés. Los resultados señalan que las variables clase social de origen, educación de los padres y ruralidad, son factores determinantes en la percepción de movilidad social. A partir de la segmentación por conglomerados, se concluyó que el acceso a la educación superior no es un factor determinante en la proyección de movilidad social futura para los estudiantes universitarios mapuche y, cuando así lo perciben, se trata de una movilidad intraclase.

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Potential Impact of the Z0011 Trial on the Omission of Axillary Dissection: A Retrospective Cohort Study
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Shinzato, Julia Yoriko

; Serra, Katia Piton

; Eugeni, Caroline

; Cabello, Cesar

; Cardoso-Filho, Cassio

; Zeferino, Luís Carlos

Revista Brasileira de Ginecologia e Obstetrícia

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apr 2021, Volume 43 N. 4 Pages 297 - 303

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Avaliar o número de pacientes com câncer de mama em estágio inicial que se beneficiariam da omissão da linfadenectomia axilar segundo o protocolo Z0011 da Alliance for Clinical Trials in Oncology (ACOSOG). Métodos Estudo de coorte retrospectiva conduzido no Hospital da Mulher da Universidade Estadual de Campinas. Foram incluídas mulheres diagnosticadas com carcinoma invasivo de mama em estágio inicial, com axila clinicamente negativa, tratadas com cirurgia conservadora e biópsia do linfonodo sentinela, radioterapia, quimioterapia e/ou hormonioterapia, de janeiro de 2005 a dezembro de 2010. Os critérios do estudo da ACOSOG Z0011 foram aplicados a essas mulheres e foi realizada uma análise estatística que comparou ambas as populações dos estudos. Resultados Foram estudadas 384 mulheres submetidas a cirurgia conservadora de mama e biópsia do linfonodo sentinela. Entre elas, 86 mulheres foram submetidas a linfadenectomia axilar por metástase presente no linfonodo sentinela. Uma paciente foi submetida a linfadenectomia axilar por ter um linfonodo palpável suspeito no intraoperatório, não incluída no estudo. Entre essas 86 pacientes, 82 (95,3%) tiveram de 1 a 2 linfonodos sentinela comprometidos e seriam elegíveis para omissão da linfadenectomia axilar pelos critérios do ACOSOG Z0011. Entre as 82 pacientes elegíveis, apenas 13 (15,9%) delas apresentaram tumores com invasão angiolinfática, e 62 (75,6%) dos tumores mediram até 2 cm (T1). Conclusão Os critérios do estudo ACOZOG Z0011 podem ser aplicados a um seleto grupo de pacientes com linfonodo sentinela positivo reduzindo os custos e a morbidade cirúrgica do tratamento do câncer de mama.

Abstract Objective To evaluate the number of patients with early-stage breast cancer who could benefit from the omission of axillary surgery following the application of the Alliance for Clinical Trials in Oncology (ACOSOG) Z0011 trial criteria. Methods A retrospective cohort study conducted in the Hospital da Mulher da Universidade Estadual de Campinas. The study population included 384 women diagnosed with early-stage invasive breast cancer, clinically negative axilla, treated with breast-conserving surgery and sentinel lymph node biopsy, radiation therapy, chemotherapy and/or endocrine therapy, from January 2005 to December 2010. The ACOSOG Z0011 trial criteria were applied to this population and a statistical analysis was performed to make a comparison between populations. Results A total of 384 patients underwent breast-conserving surgery and sentinel lymph node biopsy. Of the total number of patients, 86 women underwent axillary lymph node dissection for metastatic sentinel lymph nodes (SNLs). One patient underwent axillary node dissection due to a suspicious SLN intraoperatively, thus, she was excluded fromthe study. Among these patients, 82/86 (95.3%) had one to two involved sentinel lymph nodes andmet the criteria for the ACOSOG Z0011 trial with the omission of axillary lymph node dissection. Among the 82 eligible women, there were only 13 cases (15.9%) of lymphovascular invasion and 62 cases (75.6%) of tumors measuring up to 2 cm in diameter (T1). Conclusion The ACOSOG Z0011 trial criteria can be applied to a select group of SLNpositive patients, reducing the costs and morbidities of breast cancer surgery.

https://doi.org/10.1055/s-0041-1725052 148 downloads

Background parenchymal enhancement: behavior during neoadjuvant chemotherapy for breast cancer and relationship with a pathological complete response
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Teixeira, Sandra Regina Campos

; Camargo Júnior, Hélio Sebastião Amâncio de

; Cabello, Cesar

Radiologia Brasileira

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apr 2020, Volume 53 N. 2 Pages 95 - 104

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Avaliar o realce de fundo do parênquima (RFP), suas características e seu comportamento pré- e pós-quimioterapia neoadjuvante (QTN) em ambas as mamas em pacientes com câncer de mama unilateral. Materiais e Métodos: Estudo observacional transversal retrospectivo realizado em um serviço acadêmico e um centro especializado em mamas, que incluiu mulheres com câncer de mama invasivo submetidas a QTN e que realizaram exames de ressonância magnética (RM) das mamas com contraste antes e depois da quimioterapia, entre julho de 2007 e julho de 2017. Os exames foram realizados de acordo com protocolo padronizado. O RFP foi avaliado em ambas as mamas de acordo com o ACR BI-RADS, 5ª edição. Foi aplicada análise de regressão logística. O nível de significância adotado para os testes estatísticos foi p < 0,05. Resultados: Foram analisadas 150 mulheres. A idade média foi de 45,2 anos (20–74 anos). Na análise de regressão multivariada, apenas a idade inferior a 50 anos e redução do RFP correlacionaram-se independentemente com o nível alto de RFP em ambas as mamas: mamas afetadas (odds ratio [OR]: 6,55; intervalo de confiança 95% [IC 95%]: 2,32–18,46 e OR: 17,75; IC 95%: 4,94–63,73, respectivamente); mamas contralaterais (OR: 6,55; IC: 95% 2,32–18,46 e OR: 18,47; IC 95%: 5,19–66,49, respectivamente). Conclusão: Idade abaixo de 50 anos e redução do RFP pós-QTN correlacionaram-se independentemente com maior RFP pré-QTN em ambas as mamas em pacientes com câncer de mama invasivo unilateral submetidas a QTN.

Abstract Objective: To evaluate background parenchymal enhancement (BPE) and its characteristics, as well as its behavior before and after neoadjuvant chemotherapy (NAC), in both breasts of patients with unilateral breast cancer. Materials and Methods: This was a retrospective, cross-sectional observational study involving a consecutive sample of women with invasive breast cancer who underwent breast magnetic resonance imaging (MRI) between July 2007 and July 2017, as well as undergoing dynamic contrast-enhanced MRI before and after NAC. In both breasts, we evaluated the BPE in accordance with the Breast Imaging Reporting and Data System. We applied logistic regression analysis, and values of p < 0.05 were considered significant. Results: We evaluated 150 women. The mean age was 45.2 years (range, 20-74 years). The variables correlating independently with a high pre-NAC BPE, in the affected and contralateral breasts, were being under 50 years of age (odds ratio [OR] = 6.55; 95% confidence interval [95% CI]: 2.32-18.46, for both breasts) and a post-NAC BPE reduction (OR = 17.75; 95% CI: 4.94-63.73 and OR = 18.47; 95% CI: 5.19-66.49, respectively). Conclusion: Patients with invasive unilateral breast cancer who have a high pre-NAC BPE in both breasts tend to be under 50 years of age and to show a post-NAC reduction in BPE.

https://doi.org/10.1590/0100-3984.2019.0057 1163 downloads

Trabajos de investigación presentados en el L Congreso Mexicano de Anestesiología: Chihuahua 2017. México
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Ríos Medrano, Alea Fernanda

; Herrero Trujillano, Manuel

; Robles López, Maria Decire

; Rodríguez Barajas, Ruben

; Gutiérrez-Martínez, Paola Virginia

; Ramírez-Gómez, Melba

; Olvera-Hernández, Jesus Arnoldo

; Márquez Noyola, Elizabeth Alicia

; Almonte de León, Héctor

; Hernández Mancilla, Arturo

; Castro Salinas, José Ernesto

; Medrano-Duarte, Olga Abigahil

; Ramírez-Mendoza, Karla

; Rodriguez-Nieves, Georgina Monserrat

; Pareces Ríos, Adriana

; Ruiz-Rubio, Yolanda

; Hernández-Santiago, María Guadalupe

; Ramírez Mendoza, Karla

; Medrano Duarte, Olga Abigahil

; Martínez-Alpuche, Rocío Adriana

; Valenzuela-Priego, Francisco

; Álvarez-Santiago, José Heriberto

; Lugo-Rodríguez, Julian

; Betancourt-Sandoval, Alonso

; Prince-Angulo, Silvia Annel

; Martínez-Felix, Israel

; Salazar-Castro, Laura

; Espinazo-Quintero, Erendira

; Otañez, Monica Thalia

; Priego, Gloria

; Alzate, Ana Lizette

; Salazar, Laura Elena

; Nieblas, Mariela

; Martinez, Israel

; Alvarez-Betancourt, Ana Elsa

; Sánchez-Hernández, Eloy

; Romo-Serrano, Erika

; Rodríguez-Jauregui, Adriana

; Díaz-Aceves, Erica Raquel

; Arteaga-Trejo, Jaime

; Rodríguez-Jáuregui, Adriana

; Robles-Lopéz, María Decire

; Ibarra-González, María Livier

; Alvarez-Betancourt, Ana Elsa

; Díaz-Aceves, Erica Raquel

; Arteaga-Trejo, Jaime

; Santana-Sonora, Beatriz Alejandra

; Prince-Angulo, Silvia Annel

; Sandoval-Rivera, Arturo Guadalupe

; Camacho-López, Jesús Erick

; Alzate-Moctezuma, Ana Lizette

; Valencia-Echávarri, Andrea

; Canales-Bonilla, Carlos Patricio

; Ramos-Hernández, Julia Demetria

; Flores-Posada, Jesus Jonathan

; Muñoz Garcia, Aleyda

; Osorio Santiago, Maria Areli

; Lopez Cartita, Victor

; Ortega, Julio

; Fuentes García, Víctor E

; Moyao García, Diana

; Villars Zamora, Elvia Gabriela

; Prince Angulo, Silvia Annel

; Gerardo Angulo, Alma Ruth

; Martinez Felix, Israel

; Ayala Camargo, Yuridia

; Esquer de la Rosa, Jaquelyn Roxana

; Trapaga Millares, Yazmin

; Sánchez León, Claudia Elena

; Vásquez Puente, Felipe

; Rojo Medina, Victor Javier

; Urias Romo de vivar, Emma Gabriela

; Prince Angulo, Silvia Annel

; Ojeda Ramos, Joel

; Caceres Figueroa, Leonardo Andres

; Martinez Reyes, Maria Fernanda

; Contreras Ramírez, Nathalie

; Martínez Barreto, Nelly

; Ruelas León, Berenice

; Reyes Salgado, Karla

; Ruvalcaba Sánchez, Rafael

; Núñez Valencia, Carolina

; Escamilla Asiain, Gabriela

; Carranza-Cortés, José Luis

; Puga-Flores, Eva del Carmen

; Jiménez-Cardona, María Beatriz

; Puga-García, Diana Marisol

; Alcaraz-Ramos, Rosina

; Martinez-Delgado, Olinda

; Zamudio-Gracia, Carlos Amador

; Mireles Vega, Elizabeth

; Hernández López, Clara

; Ceballos Niño, Jose Luis

; Carreño Caballero, Jessica

; Montiel Jarquín, Álvaro José

; López García, Ingrid

; Serrano Cuevas, Beatriz

; Martinez Marin, Dolores Guillermina

; Díaz-Aceves, Erica Raquel

; Romo-Serrano, Erika

; Campechanos-Asencio, María de los Ángeles

; Rodríguez-Jáuregui, Adriana

; Betancourt-Álvarez, Ana Elsa

; Arteaga-Trejo, Jaime

; Romo-Serrano, Erika

; Rios-Navarro, Ramón Alejandro

; Rodriguez-Jauregui, Adriana

; Alvarez-Betancourt, Ana Elsa

; Diaz Aceves, Érica Raquel

; Calleja-Zenteno, Liliana

; Fernández-Vázquez, María Urbelina

; Carreño-Caballero, Jessica

; Serrano Cuevas, Beatriz

; Montiel Jarquín, Álvaro José

; Carreño- Caballero, Jessica

; Cortes- Pineda, Claudia

; Fernández-Vázquez, María Urbelina

; Hernández-Domínguez, Juan

; Serrano-Cuevas, Beatriz

; Ruiz- Luna, Mayra

; Gómez-Moreno, Julieta Berenice

; Hernández-Santiago, Maria Guadalupe

; Ruiz-Rubio, Yolanda

; Ruiz-Serrano, Ana Cristina

; Medina-Flores, Aleida

; Sánchez Torres, Claudia

; Osorio Santiago, María Areli

; Lee, Angel

; Correa-Ovis, Jose Francisco

; Priego-Martínez, Luis Alberto

; Valencia-Carrillo, Miguel

; Sánchez-Arteaga, Sofia

; Cruz-Márquez, Abraham Josué

; Duran-Zamora, Karina Aurora

; Corral-Guerrero, Sergio Francisco

; Arce Bojorquez, Brisceyda

; Medina, Francisco

; Felix, Pavel

; Estrada, Haydeé Gloria

; González-Herrera, Francisco Javier

; Zepeda Olivera, Silvia

; Pablo-Yañez, Julio Cesar

; Colores Velazquez, Julio Cesar

; Calva Maldonado, Miguel

; Veyna Rocha, Sissy Barubi

; Veyna Rocha, Abraham Irishd

; Rodríguez-Rodríguez, María Guadalupe

; Castillo- Rodriguez, Juan Orlando

; Martínez-Figueroa, Brenda Paola

; Romero Guillén, Lorena Priscila

; Pavía Vega, Susy Sáez

; Jiménez Siles, María Eugenia

; Hurtado Reyes, Ignacio Carlos

; Rojas Zarco, Eder Marcelo

; Sánchez Tapia, Mario Alberto

; Villicaña-Ayala, Carolina

; Díaz-Aguilar, Marco Antonio

; Apolinar Jiménez, Evelia

; García-Parra Pérez, Paola Carolina

; García-Parra Pérez, Natalia Cristina

; Yee-Rendón, Zumey

; Valle-Leal, Jaime Guadalupe

; Reyes-Jiménez, Gerardo Antonio

; Ortiz-Magallanes, Elías

; Sanchez-Aguilar, Maricela

; Mota-Figueroa, Roanne Patrician

; Espinosa-Tadeo, Aldo Ernesto

; Díaz-Hernández, Alejandro Eduardo

; Cendón-Ortega, María Mercedes

; Ortega-Ponce, Fabiola Estela Elizabeth

; Romero-Guillen, Lorena Priscila

; Cruz Castañedo, Greta

; Constantino-Rivera, Luis Armando

; Gordillo-Paniagua, Jorge Alberto

; Contreras-Ramírez, Nathalie

; Bernal-Zambrano, Luis Omar

; Flores-Alvarado, Rosa María

; Ferrera-Sarquís, María Aurora

; Espino Vega, Ana Frain

; Guillen-Narváez, María del Rocio

; López-García, Rocío Angélica

; Martínez-Sánchez, Angélica

; Huerta-Beltrán, Juana Geraldine

; Gómez-Rojas, Juan Pablo

; Rivera-Ruiz, Rodolfo Eduardo

; Ramírez Reyes, Liliana Georgina

; Muñoz Martínez, Raúl

; Martínez-Morales, Nayeli Noemi

; Mariscal-Cervantes, Beatriz

; Chávez-Barragán, Oscar Fernando

; Barrera-de León, Juan Carlos

; Carrillo-Guerra, Valentin

; Huitrón-Hernández, José Alonso

; De la Rosa-Fabián, Viviana Marysela

; Zertuche-Méndez, David Ricardo

; Riquelme Holguin, Karla Talia

; Gutierrez Beltran, Maria del Refugio

; Martinez-Tapia, Maria Elena

; Amezquita Esparza, Monica

; Portillo Villalobos, Samantha

; Díaz Solís, Erick Iván

; Estrada Utrera, Maria Sandra

; Islas Ruz, Félix Gilberto

; Pérez Díaz, Roberto

; Chávez-Contreras, Sara Idali

; Zepeda Olivera, Silvia

; Calva-Maldonado, Miguel

; Fragoso-Avilés, Fabían

; Rosa-Moya, Griselda de la

; Ávila-López, Armando

; López Castruita, Victor Manuel

; Manrique Carmona, Luisa Piedad

; Ramírez- Martínez, Elizabeth

; Rojas-Peñaloza, Janeth

; López-Gómez, Antonio

; Veyna Rocha, Abraham Irishd

; Veyna Rocha, Sissy Barubi

; Torres Hernández, Rosa

; Aleman-Ortega, Cristina

; Guevara-Pérez, Alejandra

; Castillo Gamez, Tobias Francisco

; Gutierrez Beltran, María del Refugio

; Martínez Tapia, María Elena

; Alanis Uribe, Karla

; Guerrero Morales, Fernando

; Molina Rodríguez, Gloria

; Gómez Cruz, José Roberto

; Tapia Castro, Gabriela

; Ley, Marcial Luis

; Castro Ortega, Julio

; Martínez, Leo Bruno

; Portugal Moreno, Víctor Hugo

; García Cabello, Luis Manuel

Anestesia en México

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apr 2017, Volume 29 N. 1 Pages 29 - 89

Abstract: Es | Text: Es | PDF: Es

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Susceptibilidad a la variabilidad ambiental del sector acuícola en el Estado de Colima, México: caso de estudio
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Liñan-Cabello, Marco Agustin

; Quintanilla-Montoya, Ana Luz

; Sepúlveda-Quiroz, Cesar

; Cervantes-Rosas, Omar D

Latin american journal of aquatic research

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jul 2016, Volume 44 N. 3 Pages 649 - 656

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

En México, como en muchos otros países de Latino América, la carencia de un plan de desarrollo y/o prevención en acuicultura ante la variabilidad ambiental es evidente. En el Estado de Colima, la acuicultura presenta rezagos en cuanto a la capacidad técnica-productiva, en especial para el cultivo de tilapia Oreochromis spp. Se practicaron encuestas a acuicultores y expertos, además de consultar fuentes bibliográficas científicas, y la identificación de diferentes factores de riesgo emanados de la práctica de la actividad acuícola para valorar la vulnerabilidad del sector. El principal factor de riesgo se asoció a fenómenos hidrometeorológicos, para lo cual se reconoce la necesidad de delimitar zonas de mayor riesgo, más aún, ante la incertidumbre de los mismos debido al cambio climático global. El presente estudio propone implementar un programa integral de reconversión tecnológica y medidas de control para especies exóticas que, además, considere esquemas de producción acuícola basadas en el uso eficiente del agua, y considere para ello el uso de especies endémicas para su cultivo.

In Mexico, as in many other Latin American countries, the lack of a development plan and/or prevention in aquaculture to environmental variability is evident. In the State of Colima, aquaculture presents lags in terms of technical and productive capacity especially for growing tilapia Oreochromis spp. Surveys were performed to farmers and experts, in addition to consulting scientific literature sources, and identifying different risk factors arising from the practice of aquaculture in order to assess the vulnerability of the sector. The main risk factor associated with hydrometeorological phenomena, for which the need to define high-risk areas, even more, given the uncertainty of the same due to global climate change is recognized. This study proposes to implement a comprehensive program of technological conversion and control measures for alien species that also consider aquaculture production schemes based on the efficient use of water, and to consider using this endemic species for cultivation.

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Características clínicas y bioquímicas en pacientes con histología compatible con esteatohepatitis del Hospital Nacional Arzobispo Loayza, Lima, Perú en el 2010-2012
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Alegría Matos, Paola Hilda

; Tafur Cabello, Kelly Stephanie

; Lozano Miranda, Adelina

; Loza Munarriz, Cesar

; Lozano Miranda, Zenaida

Revista de Gastroenterología del Perú

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jul 2015, Volume 35 N. 3 Pages 236 - 242

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Objectives: Describe the clinical and biochemical characteristics of patients with histopathological findings compatible with steatohepatitis of HNAL patients between 2010-2012. Determine the frequency of alcoholic and non-alcoholic steatohepatitis, presence of metabolic syndrome and other factors associated to non-alcoholic steatohepatitis, its main indications for liver biopsy and biochemical characteristics according to the severity of the histological findings. Materials and methods: We evaluated all histological slides of liver biopsies of the period between 2010-2012, of which, those with the diagnosis of steatohepatitis were selected. Their medical records were then reviewed. Results: 32 patients met inclusion criteria. 28 were female and 4 male, the average age was 49±12 years. Two patients had a history of chronic alcohol consumption, representing the group of alcoholic steatohepatitis. The more frequent clinical finding in patients with NASH (non-alcoholic steatohepatitis), was obesity (37%). 50% of patients had AST/ALT ratio <1. Conclusions: Among population studied, non-alcoholic steatohepatitis was more common than alcoholic steatohepatitis, being obesity the most associated factor.

Objetivos: Describir las características clínicas y bioquímicas en pacientes con histología compatible con esteatohepatitis del Hospital Nacional Arzobispo Loayza en el periodo 2010-2012. La frecuencia de esteatohepatitis alcohólica y no alcohólica, la presencia de síndrome metabólico y otros factores asociados a esteatohepatitis no alcohólica, sus principales indicaciones de biopsia hepática, y las características bioquímicas de acuerdo a la severidad del cuadro histológico. Materiales y métodos: Se evaluaron todas las biopsias hepáticas del período 2010-2012, se seleccionaron las muestras con diagnóstico de esteatohepatitis. Luego se revisaron sus respectivas historias clínicas. Resultados: 32 pacientes con esteatohepatitis cumplieron los criterios de inclusión, 28 fueron de sexo femenino y 4 masculino, cuya edad fue 49±12 años, 30 (94%) presentaba esteatohepatitis no alcohólica. Dos pacientes presentaban el antecedente de consumo crónico de alcohol, representando al grupo de esteatohepatitis alcohólica. La característica clínica más frecuente en pacientes con esteatohepatitis no alcohólica, fue obesidad en 11 (37%) pacientes. La relación de AST/ALT <1 estuvo presente en 15 (50%) pacientes. Conclusiones. En esta población la esteatohepatitis no alcohólica es mucho más frecuente que la alcohólica y la obesidad estuvo más relacionada con la presencia de esteatohepatitis no alcohólica.

Prevalencia de sobrepeso y obesidad en adolescentes de un distrito urbano de Lima, Perú 2012
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Lozano-Rojas, Gaudi

; Cabello-Morales, Emilio

; Hernádez-Diaz, Herminio

; Loza-Munarriz, Cesar

Revista Peruana de Medicina Experimental y Salud Pública

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sep 2014, Volume 31 N. 3 Pages 494 - 500

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Objectives. To determine the prevalence of overweight and obesity according to the criteria of the WHO and CDC in adolescents from an urban district of Lima, Peru 2012. Materials and methods. This cross-sectional study included 1,743 school children of 12 to 17 years of age selected from ten public and private educational institutions, using a randomized and stratified sample of “conglomerados” (neighborhoods). In the selected schools, weight and height were measured. For the diagnosis of overweight and obesity, criteria from the WHO and CDC were used. For data analysis, descriptive and inferential statistics were performed. Results. According to the WHO criteria, the prevalence of overweight was 33.7% (95% CI 31.5-36.0) and obesity was 14.4% (95% CI 12.8-16.1). According to CDC criteria, the prevalence of overweight was 26.5% (95% CI 24.4-28.6) and obesity was 13.9% (95% CI 12.3-15.6). The prevalence of overweight and obesity was significantly higher in males aged 12 and 13 years old and private educational institutions (p<0.05). We found very good agreement between the WHO and CDC criteria for the diagnosis of overweight and obesity. Conclusions. A high prevalence of overweight and obesity was found, predominantly in male students between 12 and 13 years and private educational institutions. It is necessary to initiate intervention measures that can contribute to the prevention of chronic diseases in adulthood, secondary to obesity in adolescence

Objetivos. Determinar la prevalencia de sobrepeso y obesidad en adolescentes de un distrito urbano de Lima, Perú 2012. Materiales y métodos. Estudio transversal analítico, se incluyeron 1743 escolares de 12 a 17 años de edad seleccionados de diez instituciones educativas públicas y privadas, mediante una muestra por conglomerados, estratifi y aleatorio. En los escolares de las instituciones seleccionadas, se midió peso y talla. Para el diagnóstico de sobrepeso y obesidad se utilizó los criterios de la Organización Mundial de la Salud (OMS) y el Centers for Disease Control and Prevention (CDC). En el análisis de datos se empleó estadística descriptiva e inferencial. Resultados. Según los criterios de la OMS la prevalencia de sobrepeso fue 33,7% (IC 95%: 31,5-36,0) y obesidad 14,4% (IC 95%:12,8-16,1). Según criterios del CDC la prevalencia de sobrepeso fue 26,5% (IC 95%: 24,4-28,6) y obesidad 13,9% (IC 95%: 12,3-15,6). La prevalencia de sobrepeso y obesidad fue signifi mayor en varones de 12 y 13 años de edad e instituciones educativas privadas (p<0,05). La concordancia entre los criterios de la OMS y el CDC para el diagnóstico de sobrepeso y obesidad fue muy buena. Conclusiones. Se encontró una alta prevalencia de sobrepeso y obesidad, con predominio en varones, escolares de 12 y 13 años e instituciones educativas privadas. Es necesario iniciar medidas de intervención que contribuyan a prevenir las enfermedades crónicas en la adultez, secundarias a la obesidad en la adolescencia

3142 downloads

10.

Validation of the instrument "Body image after breast cancer" in Brazil
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Gonçalves, Carolina de Oliveira

; Tavares, Maria da Consolação Gomes Cunha Fernandes

; Campana, Angela Nogueira Neves Betanho

; Cabello, César

Motriz: Revista de Educação Física

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mar 2014, Volume 20 N. 1 Pages 8 - 15

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

A imagem corporal é um importante componente a ser considerado durante o tratamento do câncer de mama em mulheres, o que reforça a importância de um instrumento de qualidade para avaliar esta condição. O instrumento validado neste estudo pode trazer novas possibilidades de estudar os efeitos de tratamentos de câncer de mama na imagem corporal. Na validação do questionário, tradução, adaptação cultural do instrumento e pré-testes foram realizados com mulheres com câncer de mama residentes nos Estados de Alagoas, Pernambuco e São Paulo. A análise estatística nos mostra que o instrumento é válido, confiável e uma ferramenta importante na identificação do impacto do câncer de mama na imagem corporal, permitindo ajustes nas condutas de tratamento clínico, apoio psicológico e na ação de outros profissionais envolvidos no tratamento.

The body image is an important aspect to be considered during the treatment of women with breast cancer. Therefore, we understand the importance of the quality of an instrument that evaluates this condition. The instrument validated in this study can bring new possibilities of studying the effects of cancer treatments on body image. Validation of the questionnaire, translation, cultural adaptation and pre-tests were done with women with breast cancer residents of the States of Alagoas, Pernambuco and São Paulo. A Confirmatory Factor Analysis (CFA) demonstrated that the original model of the instrument is valid, reliable and can be an important tool for identifying the impact of breast cancer on body image of women with this health condition, allowing adjustments in clinical treatment, psychological support and actions of other professionals involved in the treatment.

La imagen corporal es un componente importante a considerar en el tratamiento de cáncer de mama en las mujeres, lo que refuerza la importancia de un instrumento de calidad para evaluar esta condición. El instrumento validado en este estudio puede aportar nuevas posibilidades para estudiar los efectos de los tratamientos para el cáncer de mama en la imagen corporal. Validación del cuestionario, traducción, adaptación cultural del instrumento y los pre-testes se llevaron a cabo con las mujeres con cáncer de mama que viven en los Estados de Alagoas, Pernambuco y Sao Paulo. El análisis estadístico muestra que el instrumento es válido, confiable y una herramienta importante para identificar el impacto del cáncer de mama en la imagen corporal, lo que permite ajustes en el tratamiento clínico, conductas de apoyo psicológico y de la acción de otros profesionales que participan en el tratamiento.

https://doi.org/10.1590/S1980-65742014000100002 4662 downloads

11.

Localization of metastasis within the sentinel lymph node biopsies: a predictor of additional axillary spread of breast cancer?
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Alvarenga, César Augusto

; Santos, César Cabello dos

; Alvarenga, Marcelo

; Paravidino, Paula Itagyba

; Morais, Sirlei Siani

; Brenelli, Henrique Benedito

; Carvalho, Filomena Marino de

Revista Brasileira de Ginecologia e Obstetrícia

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nov 2013, Volume 35 N. 11 Pages 483 - 499

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO:Explorar a relação entre características morfológicas e localização histológica da metástase dentro dos linfonodos sentinelas (LS) e disseminação axilar em mulheres com câncer de mama. MÉTODOS: Foram selecionados 119 pacientes com LS positivo, submetidas à dissecação completa dos linfonodos axilares entre Julho de 2002 a Março de 2007. Foram recuperados a idade das pacientes e o tamanho do tumor primário. No tumor primário, avaliamos os graus histológico e nuclear e a invasão vascular peritumoral (IVP). Nos LS, avaliamos o tamanho da metástase, sua localização no linfonodo, o número de focos metastáticos, número de linfonodos envolvidos e a extensão extranodal. RESULTADOS: Cinquenta e um (42,8%) pacientes tiveram metástases adicionais confirmadas nos linfonodos não sentinelas (LNS). Alto grau histológico, IVP, metástase intraparenquimatosa, extensão extranodal e tamanho da metástase foram associados com LNS positivos. Metástase afetando a cápsula do LS foi associada com baixo risco de incidência de metástase adicional. Após análise multivariada, IVP e tamanho da metástase no LS foram os fatores de risco mais importantes para metástases adicionais nos LNS. CONCLUSÕES:O risco de envolvimento adicional dos LNS é maior em pacientes com IVP e tal risco aumenta progressivamente de acordo com a localização histológica da metástase no LS, que inicia na cápsula, onde aporta o linfático aferente, e termina no lado oposto, promovendo a extensão extranodal. Tamanho de metástase maior ou igual a 6,0 mm revela maior risco de metástase nos LNS.

PURPOSE: To explore the relationship between morphological characteristics and histologic localization of metastasis within sentinel lymph nodes (SLN) and axillary spread in women with breast cancer. METHODS: We selected 119 patients with positive SLN submitted to complete axillary lymph node dissection from July 2002 to March 2007. We retrieved the age of patients and the primary tumor size. In the primary tumor, we evaluated histologic and nuclear grade, and peritumoral vascular invasion (PVI). In SLNs we evaluated the size of metastasis, their localization in the lymph node, number of foci, number of involved lymph nodes, and extranodal extension. RESULTS: Fifty-one (42.8%) patients had confirmed additional metastasis in non-sentinel lymph nodes (NLSN). High histologic grade, PVI, intraparenchymatous metastasis, extranodal neoplastic extension and size of metastasis were associated with positive NLSN. SLN metastasis affecting the capsule were associated to low risk incidence of additional metastasis. After multivariate analysis, PVI and metastasis size in the SLN remained as the most important risk factors for additional metastasis. CONCLUSIONS:The risk of additional involvement of NSLN is higher in patients with PVI and it increases progressively according the histologic localization in the lymph node, from capsule, where the afferent lymphatic channel arrives, to the opposite side of capsule promoting the extranodal extension. Size of metastasis greater than 6.0 mm presents higher risk of additional lymph node metastasis.

22098 downloads

12.

Métodos de extracción de semilla en papaya Golden y la relación con la longevidad
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García Dean, Julio César

; Vázquez Badillo, Mario Ernesto

; Torres Tapia, María Alejandra

; Dávila Cabello, Sergio Ignacio

; Sánchez Aspeytia, David

Revista mexicana de ciencias agrícolas

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apr 2011, Volume 2 N. 2 Pages 281 - 288

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

It is very scarce available information related to post-harvest handling of papaya seed (Carica papaya L.) and their influence in seed physiologic quality, mainly in germination and vigor. The investigation work was carried out in seeds production laboratory of Center of Training and Development of Seeds Technology, in greenhouse number one of Universidad Autónoma Agraria "Antonio Narro" (UAAAN) during 2008. Aim of work was to evaluate six treatments of seed extraction: hydrochloric acid was used (HCl) at 0.3 and 0.5% during one hour of rest, sulfuric acid (H2SO4) at 0.3% with 1.5 h of rest, sodium hypochlorite (NaClO) at 5% with 30 minutes of rest and fermentation at 48 and 72 h. Extracted seed was stored during 90, 180 and 240 days at 4 °C. It was evaluated seed germination and vigor. A totally random design was used with factorial arrangement. Results indicated that seed physiologic quality was affected by deterioration effects caused by storage and by methods of seed extraction; however, seed conserves its physiologic quality up to 240 days of storage, in treatments with help of HCl at 0.3% and fermentation for 24 h with 93.3 and 91.2 % germination after 240 days of storage.

Es muy escasa la información disponible, relacionada al manejo de poscosecha de semilla de papaya (Carica papaya L.) y su influencia en la calidad fisiológica de la semilla, sobre todo en germinación y vigor. El trabajo de investigación se realizó en el laboratorio de producción de semillas del Centro de Capacitación y Desarrollo de Tecnología de Semillas, en el invernadero número uno de la Universidad Autónoma Agraria "Antonio Narro" (UAAAN) durante 2008. La finalidad del trabajo fue evaluar seis tratamientos de extracción de semilla: se utilizó ácido clorhídrico (HCl) a 0.3 y 0.5% durante una hora de reposo, ácido sulfúrico (H2SO4) a 0.3% a 1.5 h de reposo, hipoclorito de sodio (NaClO) al 5% con media hora de reposo y fermentación a 48 y 72 h. La semilla extraída fue almacenada durante 90, 180 y 240 días a 4 °C. Se evaluó la germinación y vigor de la semilla. Se utilizó un diseño completamente al azar con arreglo factorial. Los resultados indicaron que la calidad fisiológica de la semilla, fue afectada por los efectos de deterioro que causa el almacenamiento y por los métodos de extracción de semilla; sin embargo, la semilla conserva su calidad fisiológica hasta los 240 días de almacenamiento, en los tratamientos a base de HCl al 0.3% y fermentación por 24 h con 93.3 y 91.2% de germinación después de 240 días de almacenamiento.

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13.

Breast density in women with premature ovarian failure or postmenopausal women using hormone therapy: analytical cross-sectional study
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Soares, Patrícia Magda

; Cabello, César

; Magna, Luis Alberto

; Tinois, Eduardo

; Benetti-Pinto, Cristina Laguna

Sao Paulo Medical Journal

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jul 2010, Volume 128 N. 4 Pages 211 - 214

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

CONTEXTO E OBJETIVO: Estudos com mulheres na pós-menopausa relatam aumento no risco de câncer de mama relacionado ao tipo e duração da terapia hormonal (TH) utilizada. Mulheres com falência ovariana prematura (FOP) representam desafio por necessitarem de TH prolongada. Pouco se conhece sobre ação da TH nas mamas dessas mulheres. Este estudo objetivou avaliar os efeitos de um tipo de TH sobre a densidade mamária de mulheres com FOP comparativamente à de mulheres pós-menopausa. TIPO DE ESTUDO E LOCAL: Estudo de corte transversal no Departamento de Tocoginecologia, Universidade Estadual de Campinas (Unicamp). MÉTODOS: Estudaram-se 31 mulheres com FOP e 31 mulheres na pós-menopausa, todas usando TH com estrogênio conjugado equino mais acetato de medroxiprogesterona, pareadas pelo tempo de utilização da TH. Todas realizaram mamografia, analisada por digitalização e por classificação de Wolfe, estratificada em duas categorias: não densa (padrão N1 e P1) e densa (P2 e Dy). RESULTADOS: Não houve diferença significativa entre a densidade mamária dos grupos analisadas por digitalização ou classificação de Wolfe. Pela digitalização, calculou-se densidade mamária média em 24.1% ± 14.6 e 18.1% ± 17.2 nas com FOP e pós-menopausa, respectivamente (P = 0,15); pela classificação de Wolfe identificou-se mamas densas em 51,6% e 29,0%, respectivamente (P = 0,171). CONCLUSÃO: Não se observou diferença na densidade mamária de mulheres com FOP comparativamente à de mulheres na pós-menopausa utilizando TH pelo mesmo período de tempo. Estes resultados podem auxiliar na aderência à TH de pacientes com FOP.

CONTEXT AND OBJECTIVE: Studies on postmenopausal women have reported increased risk of breast cancer relating to the type and duration of hormone therapy (HT) used. Women with premature ovarian failure (POF) represent a challenge, since they require prolonged HT. Little is known about the impact of prolonged HT use on these women's breasts. This study aimed to evaluate the effects of one type of HT on the breast density of women with POF, compared with postmenopausal women. DESIGN AND SETTING: Cross-sectional study at the Department of Obstetrics and Gynecology, Universidade Estadual de Campinas (Unicamp). METHODS: 31 women with POF and 31 postmenopausal women, all using HT consisting of conjugated equine estrogen combined with medroxyprogesterone acetate, and matched according to HT duration, were studied. Mammography was performed on all subjects and was analyzed by means of digitization or Wolfe's classification, stratified into two categories: non-dense (N1 and P1 patterns) and dense (P2 and Dy). RESULTS: No significant difference in breast density was found between the two groups through digitization or Wolfe's classification. From digitization, the mean breast density was 24.1% ± 14.6 and 18.1% ± 17.2 in the POF and postmenopausal groups, respectively (P = 0.15). Wolfe's classification identified dense breasts in 51.6% and 29.0%, respectively (P = 0.171). CONCLUSION: There was no difference in breast density between the women with POF and postmenopausal women, who had used HT for the same length of time. These results may help towards compliance with HT use among women with POF.

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14.

Epidemiological study of paracoccidioidomycosis and histoplasmosis in a suburb of San Félix city, Bolívar state, Venezuela
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Cermeño, Julman

; Cermeño, Julmery

; Godoy, Gerardo

; Hernández, Isabel

; Orellán, Yida

; Blanco, Ytalia

; Penna, Salvador

; García, Luily

; Mender, Thamara

; Gonsálvez, Marisa

; López, César

; Hernández, Neudys

; Longa, Isabel

; Gottberg, Esther

; Basanta, Amarilys

; Castro, Milagros

; Millán, Iraida

; León, Walesca

; Plaz, Flor

; Jahouhari, Caroline

; Cabello, Ismery

Investigación Clínica

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jun 2009, Volume 50 N. 2 Pages 213 - 220

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

El estudio epidemiológico de las micosis profundas ha sido escaso en el estado Bolívar donde la paracoccidioidomicosis e histoplasmosis son endémicas. El objetivo de este estudio fue determinar la prevalencia de infecciones por Paracoccidioides brasiliensis e Histoplasma capsulatum en individuos residenciados en una población suburbana de San Félix, estado Bolívar, Venezuela. Se administró paracoccidioidina e histoplasmina a 300 personas voluntarias. Se realizó lectura de las pruebas a las 24 horas. La paracoccidioidina fue positiva en el 10,2% (n=28). Se observó mayor porcentaje de positividad en el grupo de 40-50 años (n=10; 35,7%). Las ocupaciones de riesgo: albañiles, agricultores y mineros, presentaron un porcentaje de positividad de 27,3% (3 de 11), mayor que el de los individuos sin riesgo aparente: mecánicos, oficios del hogar y estudiantes (25 de 264; 9,5%) (p=0,04). La histoplasmina fue positiva en el 7,6% (n=21). El mayor porcentaje de intradermorreacción positiva se observó entre los 40-50 años (n=9; 42,9%). Hubo relación significativa entre el tiempo de residencia en la localidad y la infección por H. capsulatum, demostrándose en los individuos con más de 30 años en esa localidad (p<0,05). Estos resultados muestran una prevalencia relativamente baja de infecciones por P. brasiliensis y de H. capsulatum en el área estudiada.

Epidemiologic studies of deep mycosis have been scarce in Bolívar state, where paracoccidioidomycosis and histoplasmosis are considered as endemic diseases. The aim of this study was to determine paracoccidioidomycosis and histoplasmosis prevalences in people from a suburb of San Félix, Bolívar state, Venezuela. Three-hundred volunteers agreed to participate in this study and they were inoculated with paracoccidioidine and histoplasmine. Identification and epidemiologic data were registered. Reading of skin tests after 24 hours was performed in 275 persons. Paracoccidioidine test was positive in 10.2% (n=28). A higher percentage of positive reactions in the age group of 40-50 years old (n=10; 35.7%) was observed. Bricklayers, farmers and miners were positive in 27.3 % (3 out of 11), a higher percentage than in people with other occupations. Histoplasmine test was positive in 7.6% of cases (n= 21). The higher percentage of reactivity was observed in the age group of 40-50 years old (n=9; 42.9%). There was a direct proportional relationship between staying time in the locality and H. capsulatum infection mainly in persons staying in the area for more than 30 years (p<0.05). These results showed low prevalences of P. brasiliensis and H. capsulatum infection in this area.

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15.

Randomized clinical trial on the preservation of the medial pectoral nerve following mastectomy due to breast cancer: impact on upper limb rehabilitation
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Gonçalves, Andrea de Vasconcelos

; Teixeira, Luiz Carlos

; Torresan, Renato

; Alvarenga, César

; Cabello, César

Sao Paulo Medical Journal

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2009, Volume 127 N. 3 Pages 117 - 121

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

CONTEXTO E OBJETIVO: Modificações sistemáticas técnica cirúrgica das mastectomias têm sido propostas com o objetivo de minimizar lesões dos nervos peitorais e seus efeitos. O objetivo deste artigo foi comparar força e trofismo do músculo peitoral maior (MPM) e amplitude de movimento do membro superior, homolaterais à mastectomia em mulheres com carcinoma de mama submetidas à preservação ou não do nervo peitoral medial (NPM). TIPO DE ESTUDO E LOCAL: Ensaio clínico aleatório, duplo-cego, com 30 mulheres com carcinoma de mama submetidas a mastectomias entre julho de 2002 e maio de 2003, em Campinas, Brasil. MÉTODOS: As mulheres foram alocadas em um grupo em que o NPM foi preservado e em outro no qual o NPM foi seccionado. Para análise de dados, foram utilizados os testes exato de Fisher e Wilcoxon, além das análises de variância de Friedman e Anova (análise de variância). RESULTADOS: No grupo com NPM preservado, 81% das mulheres não sofreram perda de força do MPM comparado a 31% no outro grupo (intervalo de confiança, IC = 1.21 e risco relativo, RR = 2.14, P < 0,03). Em relação a trofismo muscular (IC = 0.32 e RR = 0.89, P = 0.8), a abdução (IC = 1.36, RR = 0.89, P = 0.28) e flexão (IC = 1.36, RR = 1.93 e P = 0.8) do ombro homolateral, não houve diferenças entre os grupos. CONCLUSÃO: A preservação do MPM foi significativamente associada a manutenção da força do MPM comparada com a secção do nervo. Não foram encontradas diferenças no trofismo muscular ou na amplitude de movimento do ombro entre os grupos. REGISTRO DE ENSAIO CLÍNICO NÚMERO: ACTRN - 12609000945224

CONTEXT AND OBJECTIVE: Systematic modifications to the surgical technique of mastectomy have been proposed with the objective of minimizing injuries to the pectoral nerves and their effects. The aim of this study was to compare muscle strength and mass of the pectoralis major muscle (PMM) and abduction and flexion of the homolateral upper limb following mastectomy among women with breast cancer undergoing either preservation or sectioning of the medial pectoral nerve (MPN). DESIGN AND SETTING: Randomized, double-blind, clinical trial on 30 women with breast cancer who underwent mastectomy between July 2002 and May 2003 in Campinas, Brazil. METHODS: The women were allocated to a group, in which the MPN was preserved, or to another group in which it was sectioned. Fisher's exact and Wilcoxon tests were used to analyze the data, along with Friedman and ANOVA analysis of variance. RESULTS: In the MPN preserved group, 81% of the women did not lose any PMM strength, compared with 31% in the sectioned MPN group (confidence interval, CI = 1.21; relative risk, RR = 2.14; P < 0.03). There were no differences between the groups regarding muscle mass (CI = 0.32; RR = 0.89; P = 0.8), shoulder abduction (CI = 1.36; RR = 0.89; P = 0.28) and shoulder flexion (CI = 1.36; RR = 1.93; P = 0.8). CONCLUSIONS: Preservation of the MPN was significantly associated with maintenance of PMM strength, compared with nerve sectioning. No differences in muscle mass or in abduction and flexion of the homolateral shoulder were found between the groups.

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