ABSTRACT The goal of this study was to estimate the prevalence of environmental and occupational exposure to pesticides according to sociodemographic factors among cancer patients. It is a cross-sectional study with cancer patients in the state of Mato Grosso. The prevalence of environmental and occupational exposure to pesticides was calculated as to the variables gender, age, macro-region, and education. Pesticide use per agricultural crops in liters was estimated, and a thematic map was constructed following the macro-region of the agricultural economy. Of the 998 patients, most were female (54.9%), aged between 50 and 69 years old (50.1%), had less than eight years of schooling (60.7%), and resided in the South-Central macro-region (55.4%). Regarding environmental and occupational exposure, 53.1% of the patients live or have lived in a municipality with agricultural plantations; 17.4% lived near crops; 43.4% worked in agriculture, livestock, or extractivism; and 22.9% worked or work directly with pesticides. Environmental and occupational exposure was higher in males, in the older age groups, schooling from 0 to 4 years, and in the macro-regions with higher pesticide use. The study concluded that environmental and occupational exposure among cancer patients is associated to sociodemographic characteristics and macro-regions of the agricultural economy.

RESUMO O objetivo deste estudo foi estimar a prevalência de exposição ambiental e ocupacional aos agrotóxicos conforme fatores sociodemográficos entre pacientes com câncer. Trata-se de um estudo observacional de delineamento transversal com pacientes com câncer do estado de Mato Grosso. Foi calculada a prevalência de exposição ambiental e ocupacional aos agrotóxicos conforme as variáveis sexo, faixa etária, região e escolaridade. Foram estimados o uso de agrotóxicos por culturas agrícolas em litros e construído mapa temático segundo a macrorregião de economia agropecuária. Dos 998 pacientes, a maioria era do sexo feminino (54,9%), tinha entre 50 e 69 anos (50,1%), possuía menos de oito anos de escolaridade (60,7%) e residiam na macrorregião Centro-Sul (55,4%). Em relação à exposição ambiental e ocupacional, 53,1% dos pacientes moram ou moraram em município com plantação agrícola, 17,4% residiam próximo à lavoura, 43,4% trabalharam na agricultura, pecuária ou extrativismo e 22,9% trabalharam ou trabalham diretamente com agrotóxicos. A exposição ambiental e ocupacional foi maior no sexo masculino, nas faixas etárias mais elevadas, escolaridade de 0 a 4 anos e nas macrorregiões de maior uso de agrotóxicos. Conclui-se que a exposição ambiental e ocupacional entre pacientes com câncer se associou as características sociodemográficas e macrorregiões de economia agropecuária.

RESUMO O objetivo deste estudo foi estimar a prevalência de exposição ambiental e ocupacional aos agrotóxicos conforme fatores sociodemográficos entre pacientes com câncer. Trata-se de um estudo observacional de delineamento transversal com pacientes com câncer do estado de Mato Grosso. Foi calculada a prevalência de exposição ambiental e ocupacional aos agrotóxicos conforme as variáveis sexo, faixa etária, região e escolaridade. Foram estimados o uso de agrotóxicos por culturas agrícolas em litros e construído mapa temático segundo a macrorregião de economia agropecuária. Dos 998 pacientes, a maioria era do sexo feminino (54,9%), tinha entre 50 e 69 anos (50,1%), possuía menos de oito anos de escolaridade (60,7%) e residiam na macrorregião Centro-Sul (55,4%). Em relação à exposição ambiental e ocupacional, 53,1% dos pacientes moram ou moraram em município com plantação agrícola, 17,4% residiam próximo à lavoura, 43,4% trabalharam na agricultura, pecuária ou extrativismo e 22,9% trabalharam ou trabalham diretamente com agrotóxicos. A exposição ambiental e ocupacional foi maior no sexo masculino, nas faixas etárias mais elevadas, escolaridade de 0 a 4 anos e nas macrorregiões de maior uso de agrotóxicos. Conclui-se que a exposição ambiental e ocupacional entre pacientes com câncer se associou as características sociodemográficas e macrorregiões de economia agropecuária. Tratase Trata Grosso etária agropecuária 99 54,9%, 549 54,9% , 54 9 (54,9%) 5 6 50,1%, 501 50,1% 1 (50,1%) 60,7% 607 60 7 (60,7% CentroSul Centro Sul 55,4%. 554 55,4% . 55 (55,4%) 531 53 53,1 agrícola 174 17 17,4 lavoura 434 43 43,4 agricultura 229 22 22,9 masculino elevadas Concluise Conclui 54,9 (54,9% 50,1 (50,1% 60,7 (60,7 55,4 (55,4% 53, 17, 43, 2 22, 54, (54,9 50, (50,1 60, (60, 55, (55,4 (54, (50, (60 (55, (54 (50 (6 (55 (5 (

ABSTRACT The goal of this study was to estimate the prevalence of environmental and occupational exposure to pesticides according to sociodemographic factors among cancer patients. It is a cross-sectional study with cancer patients in the state of Mato Grosso. The prevalence of environmental and occupational exposure to pesticides was calculated as to the variables gender, age, macro-region, and education. Pesticide use per agricultural crops in liters was estimated, and a thematic map was constructed following the macro-region of the agricultural economy. Of the 998 patients, most were female (54.9%), aged between 50 and 69 years old (50.1%), had less than eight years of schooling (60.7%), and resided in the South-Central macro-region (55.4%). Regarding environmental and occupational exposure, 53.1% of the patients live or have lived in a municipality with agricultural plantations; 17.4% lived near crops; 43.4% worked in agriculture, livestock, or extractivism; and 22.9% worked or work directly with pesticides. Environmental and occupational exposure was higher in males, in the older age groups, schooling from 0 to 4 years, and in the macro-regions with higher pesticide use. The study concluded that environmental and occupational exposure among cancer patients is associated to sociodemographic characteristics and macro-regions of the agricultural economy. crosssectional cross sectional Grosso gender macroregion, macroregion macro region, region education estimated economy 99 54.9%, 549 54.9% , 54 9 (54.9%) 5 6 50.1%, 501 50.1% 1 (50.1%) 60.7%, 607 60.7% 60 7 (60.7%) SouthCentral South Central 55.4%. 554 55.4% . 55 (55.4%) 531 53 53.1 plantations 174 17 17.4 434 43 43.4 agriculture livestock extractivism 229 22 22.9 males groups macroregions regions 54.9 (54.9% 50.1 (50.1% 60.7 (60.7% 55.4 (55.4% 53. 17. 43. 2 22. 54. (54.9 50. (50.1 60. (60.7 55. (55.4 (54. (50. (60. (55. (54 (50 (60 (55 (5 (6 (

Resumo Este estudo in vitro teve como objetivo investigar o efeito da nitretação por implantação iônica de plasma nas propriedades de superfície do titânio e na resposta celular inicial. Discos de titânio grau 4 (12,7 × 2 mm) foram jateados com partículas de óxido de alumínio para criar superfícies moderadamente rugosas. Os discos experimentais (TiN) foram nitrados usando a técnica de implantação iônica de plasma em uma câmara de vácuo. A caracterização da superfície foi realizada usando microscopia confocal a laser, microscopia de força atômica (AFM) e espectroscopia de fotoelétrons de raios X (XPS). A molhabilidade da superfície foi avaliada medindo o ângulo de contato de uma gota séssil usando um goniômetro. Células osteoblásticas humanas foram semeadas nos discos para avaliar a adesão e proliferação celular nos dias 1, 3, 5 e 7 de cultura, usando um ensaio de composto de tetrazólio. A atividade da fosfatase alcalina (ALP) foi medida no dia 7 para avaliar a diferenciação celular. A morfologia celular foi examinada por microscopia eletrônica de varredura (SEM) e microscopia confocal a laser. O grupo TiN exibiu micro-rugosidade similar ao grupo controle; no entanto, apresentou maior densidade de nanostruturas, aumento do conteúdo de nitrogênio e ligeira melhoria na molhabilidade. A proliferação celular e a atividade da ALP foram similares entre os grupos após sete dias de cultura. Em conclusão, a nitretação por implantação iônica de plasma melhora as nanocaracterísticas da superfície e a molhabilidade sem comprometer a biocompatibilidade do titânio, tornando-se uma técnica promissora de modificação de superfície para implantes dentários e ortopédicos. inicial 12,7 127 12 (12, mm rugosas (TiN vácuo laser AFM (AFM XPS. XPS . (XPS) goniômetro 1 3 cultura tetrazólio (ALP SEM (SEM microrugosidade micro rugosidade controle entanto nanostruturas conclusão tornandose tornando se ortopédicos 12, (12 (XPS (1 (

Abstract This in vitro study aimed to investigate the effect of plasma ion implantation nitriding on titanium's surface properties and initial cell response. Grade 4 titanium discs (12.7 × 2 mm) were blasted with aluminum oxide particles to create moderately rough surfaces. The experimental discs (TiN) were nitrided using the plasma ion implantation technique in a vacuum chamber. Surface characterization was performed using laser confocal microscopy, atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS). Surface wettability was assessed by measuring the contact angle of a sessile drop using a goniometer. Human osteoblast cells were seeded on the discs to evaluate cell attachment and proliferation at 1, 3, 5, and 7 days of culture using a tetrazolium compound assay. Alkaline phosphatase (ALP) activity was measured at day 7 to assess cell differentiation. Cell morphology was examined by scanning electron microscopy (SEM) and confocal laser scanning microscopy. The TiN group exhibited similar micro-roughness to the control group; however, it displayed a higher density of nanostructures, increased nitrogen content, and slightly improved wettability. Cell proliferation and ALP activity were similar between the groups after seven days of culture. In conclusion, plasma ion implantation nitriding enhances surface nanofeatures and wettability without compromising the biocompatibility of titanium, making it a promising surface modification technique for dental and orthopedic implants. titaniums s response 12.7 127 12 (12. mm surfaces (TiN chamber AFM, AFM , (AFM) Xray X ray XPS. XPS . (XPS) goniometer 1 3 5 assay (ALP differentiation SEM (SEM microroughness micro roughness however nanostructures content conclusion implants 12. (12 (AFM (XPS (1 (

The growing awareness of health and well-being has led to increased consumption of healthy foods, such as exotic fruits, owing to their high nutritional value and global availability. However, the production and trade of exotic fruit presents significant challenges, particularly with regard to increasing supply and ensuring food safety concerning pesticide residues. This review examines modern analytical strategies employed to determine pesticide residues in exotic fruits. It is evident from the literature that ultra-high performance liquid chromatography and gas chromatography techniques, coupled with tandem mass spectrometry, remain the methods of choice for determining pesticide residues. For sample preparation, the QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) method, renowned for its simplicity and efficiency, is extensively utilized in its original form as well as in acetate, citrate, and other modified versions to enhance its effectiveness. Developing these analytical methods is crucial for ensuring the safety of exotic fruits, protecting consumer health, and facilitating exports to global markets. Further advancements in this field are essential to overcome the challenges posed by producing and trading exotic fruits, thereby promoting food safety and public health. This review also discusses the occurrence of pesticides in exotic fruits. wellbeing being foods fruits availability However ultrahigh ultra techniques spectrometry preparation Quick, Quick (Quick Easy Cheap Effective Rugged Safe method efficiency acetate citrate effectiveness markets

BACKGROUND: Multiple sclerosis (MS), fatigue is among the leading clinical symptoms. It is one of the most disabling symptoms for most MS people. OBJECTIVES: This research measures the prevalence of fatigue and its impact on the physical, cognitive, and psychosocial abilities of individuals with MS in Morocco. METHOD: This cross-sectional and descriptive study included 152 participants. Data were collected via an online survey using the snowball method, incorporating sociodemographic characteristics and the Arabic version of the Modified Fatigue Impact Scale RESULTS: According to the results, 89.4% of respondents experienced pathological fatigue, with an average score of 65.52 (± 18.00). There was a significant relationship between pathological fatigue, age (p = 0.0324), and clinical phenotype (p = 0.041). Fatigue negatively impacted participants' physical, cognitive, and psychological capacities, with average scores of 70.38 (± 8.15), 62.28 (± 10.23), and 73.87 (± 1.86), respectively. CONCLUSION: The results of our study confirmed a high prevalence of fatigue among people with MS in Morocco. Sustained research in this field remains crucial, as it enables the formulation of strategies aimed at enhancing the quality of life for those impacted by MS CONTRIBUTION: This study is the first in Morocco to examine fatigue prevalence in people with MS and its impact on their physical, cognitive, and psychosocial abilities. High fatigue levels hinder the integration of people with MS into professional and student life. The findings emphasize the need for effective symptom and fatigue management.

Abstract: This paper presents Lexical Association Networks (LexAN), which entail the development of a mathematical model comprising a collection of words derived from a textual corpus. The interconnections between word tokens are represented by weighted edges within a non-directed graph structure. The construction process of LexAN involves 6 stages: 1) Lemmatization 2) Multi-word expressions 3) Stopwords removal 4) Co-ocurrence graph 5) Word Co-ocurrence norms, and 6) LexAN construction. We employed a Medical text corpus containing 574,011 words to build our graphs. To assess the efficacy of our LexAN, these graph structures were implemented within a tool designed to address the lexical access problem, specifically functioning as a reverse dictionary. This application resulted in favorable and promising results.

Resumo Antecedentes A discinesia induzida por levodopa (DIL) é uma complicação motora comum da terapia com levodopa em pacientes com doença de Parkinson (DP). A doxiciclina é uma tetraciclina amplamente usada e barata, com propriedade anti-inflamatória. Objetivo Avaliar a eficácia e segurança da doxiciclina em pacientes com DP e DIL. Métodos Este foi um estudo aberto, não-controlado, de braço único, monocêntrico, fase 2 e de prova de conceito, em pacientes com DP e impacto funcional das discinesias, que usavam levodopa três vezes ao dia, em um ambulatório de distúrbios de movimento no Brasil. Os participantes foram tratados com doxiciclina 200 mg/dia por 12 semanas, com avaliações na base, na semana 4 e na semana 12 do tratamento. A medida de desfecho primário foi a mudança no escore total da Unified Dyskinesia Rating Scale (UDysRS) da base à semana 12, avaliada por dois avaliadores cegos. As medidas-chave de desfecho secundário fora o tempo em OFF e tempo em ON com discinesia problemática. Resultados Oito pacientes com DP foram tratados e avaliados. A doxiciclina 200 mg/dia reduziu o escore total da UDysRS na semana 12, comparado com a avaliação inicial (χ2 de Friedman = 9.6; p = 0.008). Além disso, a doxiciclina reduziu o tempo em ON com discinesia problemática (χ2 de Friedman = 10.8; p = 0.004) sem piorar o parkinsonismo. Não houve eventos adversos graves, e dispepsia foi o evento mais comum. Conclusão No presente estudo preliminar, aberto e não-controlado, a doxiciclina foi eficaz em reduzir as DIL e segura após tratamento por 12 semanas. Estudos clínicos bem-desenhados e placebo-controlados adicionais, com duração mais longa e maior número de participantes, são necessários. (DIL DP. . (DP) barata antiinflamatória. antiinflamatória anti inflamatória. inflamatória anti-inflamatória nãocontrolado, nãocontrolado não controlado, controlado não-controlado único monocêntrico conceito discinesias dia Brasil 20 mgdia mg 1 semanas (UDysRS cegos medidaschave medidas chave avaliados χ2 χ (χ 9.6 96 9 6 0.008. 0008 0.008 0 008 0.008) disso 10.8 108 10 8 0.004 0004 004 parkinsonismo graves preliminar bemdesenhados bem desenhados placebocontrolados placebo controlados adicionais necessários (DP 9. 000 0.00 00 10. 0.0 0.

Abstract Background Levodopa-induced dyskinesia (LID) is a common motor complication of levodopa therapy in patients with Parkinson’s disease (PD). Doxycycline is a widely used and inexpensive tetracycline with anti-inflammatory properties. Objective To evaluate the efficacy and safety of doxycycline in patients with PD and LID. Methods This was an open-label, uncontrolled, single-arm, single-center, phase 2 proof-of-concept study in patients with PD with functional impact of dyskinesia, which used levodopa three times daily, in a movement disorders clinic in Brazil. Participants were treated with doxycycline 200 mg/day for 12 weeks, with evaluations at baseline, week4, and week 12 of treatment. The primary outcome measure was the change from baseline in the Unified Dyskinesia Rating Scale (UDysRS) total score at week 12, evaluated by two blinded raters. Key secondary outcomes measures were OFF time and ON time with troublesome dyskinesia in the PD home diary. Results Eight patients with PD were treated and evaluated. Doxycycline 200 mg/day reduced the UDysRS total score at week 12, compared with baseline (Friedman χ2 = 9.6; p = 0.008). Further, doxycycline reduced the ON time with troublesome dyskinesia (Friedman χ2 = 10.8; p = 0.004) without worsening parkinsonism. There were no severe adverse events, and dyspepsia was the commonest event. Conclusion In this preliminary, open-label and uncontrolled trial, doxycycline was effective in reducing LID and safe after a 12-week treatment. Further well-designed placebo-controlled clinical trials with a longer duration and a larger number of participants are needed. Clinical trial registration https://ensaiosclinicos.gov.br, identifier: RBR-1047fwbf Levodopainduced Levodopa induced (LID Parkinsons Parkinson s PD. . (PD) antiinflammatory anti inflammatory properties openlabel, openlabel open label, label singlearm, singlearm single arm, arm single-arm singlecenter, singlecenter center, center single-center proofofconcept proof concept daily Brazil 20 mgday mg day 1 weeks week4 treatment (UDysRS raters diary Friedman χ 9.6 96 9 6 0.008. 0008 0.008 0 008 0.008) 10.8 108 10 8 0.004 0004 004 parkinsonism events event preliminary 12week welldesigned well designed placebocontrolled placebo controlled needed https//ensaiosclinicos.gov.br, httpsensaiosclinicosgovbr https //ensaiosclinicos.gov.br, ensaiosclinicos gov br https://ensaiosclinicos.gov.br identifier RBR1047fwbf RBRfwbf RBR 1047fwbf fwbf (PD 9. 000 0.00 00 10. https//ensaiosclinicos.gov.br ensaiosclinicosgovbr //ensaiosclinicos.gov.br 0.0 0.

Resumo O estudo teve como objetivo avaliar a influência do material e do desenho da coroa no comportamento biomecânico de coroas implanto-suportadas com pilar híbrido (AH) por meio da análise tridimensional (3D) de elementos finitos. Os fatores de estudo foram o tipo de material do HA ou coroa (zircônia, dissilicato de lítio e cerâmica híbrida) e o desenho da coroa sobre a base de titânio (mesoestrutura cimentada à base de titânio e coroa total cimentada em cerâmica; pilar e coroa fabricados em peça única cimentada à base de titânio; coroa monolítica cimentada sobre a base de titânio e aparafusada ao implante; e coroa monolítica cimentada à base de titânio). Quatro modelos 3D foram construídos e uma carga oblíqua de 130 N foi aplicada a 45° em relação ao longo eixo do dente. Os modelos foram avaliados utilizando a tensão de von Mises para a coroa, pilar, parafuso, implante e tensão principal máxima (tensão de tração) para o tecido ósseo. As menores tensões ocorreram nos grupos que apresentaram um material com menor módulo de elasticidade, principalmente a cerâmica híbrida, considerada um material com maior resiliência. Com relação às diferentes configurações, o modelo com coroa cimentada apresentou os menores valores de tensão. As tensões foram concentradas na região cervical da coroa na interface entre coroa e base de titânio. Mesoestruturas feitas de materiais com maior módulo de elasticidade exibiram maior concentração de tensões. A presença de um orifício para parafuso aumentou a concentração de tensão na coroa de cerâmica. As coroas cerâmicas cimentadas exibiram melhor comportamento biomecânico do que as coroas parafusadas. implantosuportadas implanto suportadas AH (AH D (3D finitos zircônia, zircônia (zircônia híbrida mesoestrutura . titânio) 13 45 dente tração ósseo resiliência configurações parafusadas 1 4

Abstract This study aimed to evaluate the influence of material and crown design on the biomechanical behavior of implant-supported crowns with hybrid abutment (HA) through three-dimensional (3D) finite element analysis. The study factors were the type of material used as the mesostructure or crown (zirconia, lithium disilicate, and hybrid ceramic) and the crown design cemented to the titanium base (mesostructure cemented to the titanium base and a crown cemented on it (HaC); hybrid crown-abutment, the abutment and crown are manufactured as a single piece and cemented to the titanium base (HC); monolithic crown cemented on the titanium base and screwed to the implant (CS); and monolithic crown cemented on the titanium base (CC). Four 3D models were constructed using an implant with an internal connection, and an oblique load of 130 N was applied at 45° to the long axis of the implant. The models were evaluated using the von Mises stress for crown, abutment, screw, and implant and maximum principal stress for bone tissues. The lowest stresses occurred in the groups with a lower elastic modulus material, mainly hybrid ceramics, considered a material with greater resilience. The cemented crown group presented the lowest stress values. The stresses were concentrated in the cervical region of the crown at the titanium crown/base interface. Mesostructures made of materials with a higher elastic modulus exhibited a higher concentration of stress. The presence of a screw hole increased the stress concentration in the ceramic crown. Cemented ceramic crowns exhibited better biomechanical behavior than screw-retained crowns. implantsupported supported HA (HA threedimensional three dimensional D (3D analysis zirconia, zirconia (zirconia disilicate HaC (HaC) crownabutment, crownabutment crown-abutment HC (HC) CS (CS) CC. CC . (CC) connection 13 45 tissues ceramics resilience values crownbase interface screwretained retained (HaC (HC (CS (CC 1 4

Aim This study evaluated the influence of a wide diameter on extra-short dental implant stress distribution as a retainer for single implant-supported crowns in the atrophic mandible posterior region under axial and oblique load. Methods Four 3D digital casts of an atrophic mandible, with a single implant-retained crown with a 3:1 crown-to-implant ratio, were created for finite element analysis. The implant diameter used was either 4 mm (regular) or 6 mm (wide), both with 5 mm length. A 200 N axial or 30º oblique load was applied to the mandibular right first molar occlusal surface. The equivalent von Mises stress was recorded for the abutment and implant, minimum principal stress, and maximum shear stress for cortical and cancellous bone. Results Oblique load increased the stress in all components when compared to axial load. Wide diameter implants showed a decrease of von Mises stress around 40% in both load directions at the implant, and an increase of at least 3.6% at the abutment. Wide diameter implants exhibited better results for cancellous bone in both angulations. However, in the cortical bone, the minimum principal stress was at least 66% greater for wide than regular diameter implants, and the maximum shear stress was more than 100% greater. Conclusion Extra-short dental implants with wide diameter result in better biomechanical behavior for the implant, but the implications of a potential risk of overloading the cortical bone and bone loss over time, mainly under oblique load, should be investigated. extrashort extra short implantsupported supported D implantretained retained 31 3 1 3: crowntoimplant ratio analysis (regular wide, , (wide) length 20 º surface 40 36 3.6 angulations However 66 100 Extrashort Extra time investigated (wide 2 3. 10

Resumo O sucesso da estratégia do Prado ao Prato, que visa a transição para a sustentabilidade da agricultura europeia, irá depender das soluções tecnológicas já existentes e das que se irão desenvolver num futuro próximo. Estas tecnologias permitirão integrar diversos fatores (ex.: propriedades do solo, fatores climatéricos, fatores intrínsecos das cultivares) em avaliações preditivas das necessidades de água e nutrientes, da sintomatologia de pragas e infeções, e assim contribuir para respostas precoces, precisas e automatizadas com menor consumo de recursos e de agroquímicos. Do mesmo modo, será possível uma melhor gestão espacial do uso do solo. Contudo, a digitalização em larga escala da produção agrícola depende da eliminação de diversas barreiras sociológicas, como a iliteracia digital de muitos agricultores e técnicos de campo. Neste contexto, um consórcio formado por 14 parceiros europeus, desenvolveu o Projeto TERRATECH, submetido ao Programa ERASMUS+, que visa o desenvolvimento de um curso de mestrado em Agricultura 4.0. Durante os primeiros 18 meses, o consórcio desenvolveu o plano de estudos e os materiais didáticos para as aulas teóricas, de campo e laboratoriais. O curso inclui um período de mobilidade dos estudantes em empresas da indústria agroalimentar. O objetivo é desenvolver uma formação que possa ser transferida a outras universidades.

Abstract The success of the Farm to Fork strategy, aimed at the transition to the sustainability of European agriculture, will depend on the technological solutions that already exist and the ones that will be developed. These new technologies will allow the integration of several factors (e.g.: soil properties, climatic factors, intrinsic factors of the cultivars) in predictive assessments of water and nutrient needs, of the symptoms of pests and infections, and thus contribute to early, accurate and automated responses with less consumption of resources and agrochemicals. Similarly, better spatial management of land use will be possible. However, the large-scale digitization of agricultural production systems depends on the elimination of several sociological barriers, such as the digital illiteracy of many farmers and soil advisors. In this context, a consortium formed by 14 European partners, developed the TERRATECH Project, submitted to the ERASMUS+ Program, which aims to develop a master's course in Agriculture 4.0. During the first 18 months, the consortium developed the study plan and teaching materials for theoretical, field and laboratory classes. The course includes one period of student mobility in companies in the agri-food industry. The objective is to develop training that can be transferred to other universities.

Abstract This longitudinal study aimed to assess the performance of the Facility-Equator system as mandibular overdenture (MO) retainers from a prosthetic perspective during 2 years of loading and to investigate the oral health-related quality of life (OHRQoL) and whether prosthetic events can affect the OHRQoL. Twenty-four patients (68.1 ± 7.51 years) reported their OHRQoL through the Geriatric Oral Health Assessment Index (GOHAI) and Oral Health Impact Profile (OHIP-EDENT) questionnaires before MO loading and after 1 and 2 years of usage. Prosthetic occurrences were recorded during this period. Data were analyzed using the Wilcoxon test, Mann-Whitney test, and Spearman correlation coefficients. Of the 127 prosthetic events that occurred in the first year, the most frequent events were prosthesis adjustments (16.5%), dislodgement of the Equator attachment (14.17%), and O-ring replacement (11.8%). Eighty-seven prosthetic events were recorded in the second year, the most frequent events being prosthesis adjustments (27.6%), O-ring replacement (20.7%), and recapturing the female matrix (11.5%). All domains of the GOHAI and OHIP-EDENT questionnaires exhibited a significant difference (p < 0.05) between the baseline and 1- and 2-year evaluations, except in the Social Disability and Psychological Discomfort domains (p > 0.05) of OHIP-EDENT after 1 year. Complications related to prosthetic maintenance, such as fracturing of the prosthesis, Equator dislodgement, prosthesis rebasing, and new overdenture confection, affect the OHRQoL (p < 0.05), primarily the Physical Pain and Discomfort domains, especially in the first year of MO loading.

Abstract Biofilm on acrylic resin dental prostheses may cause gingival inflammation. This study evaluated the influence of a silicon dioxide coating layer applied onto acrylic resin on the adhesion of microorganisms. Blocks (5 x 5 x 3 mm) of acrylic resin were evaluated for surface roughness and divided into two groups: control (CG) and coated with silicon dioxide (LG group). The specimens were evaluated by scanning electron microscopy (n = 1) and by contact angle analysis (n = 3). For the in situ study, 20 volunteers wore acrylic palatal devices containing three samples from each group (n = 60) for 2 days. The biofilm formed was quantified by metabolic activity and total biomass using the crystal violet assay. The results were subjected to Bartlett’s normality test and Gamma model with random effect for the response variable (α = 5%). The mean contact angle of the coated group was significantly lower than that of the uncoated group (p < 0.05). The metabolic activity of microorganisms in the biofilm on the blocks treated with coating was significantly lower than that of control blocks (p = 0.02). Regarding the amount of extracellular matrix produced by the microorganisms, there was no difference between the CG and LG group (p = 0.05). The application of a silicon dioxide coating on acrylic resin reduced the activity of the polymicrobial biofilm formed in situ. This coating may be advantageous for patients with conventional complete dentures or implants made of acrylic resin and who have motor difficulties that prevent them from cleaning their prostheses properly.

Resumo O objetivo do estudo foi avaliar o comportamento biomecânico do tecido ósseo peri-implantar e dos componentes protéticos em duas modalidades de tratamento para região posterior da maxila, utilizando implantes curtos ou implantes de comprimento padrão associados a enxerto ósseo em seio maxilar. Foram construídos quatro modelos 3D de uma coroa suportada por um implante osseointegrado na região posterior da maxila. O tipo de implante: implante curto (S) ou implante de comprimento padrão com presença de enxerto sinusal (L) e tipo de retenção da restauração: cimentada (C) ou parafusada (S) foram os fatores de estudo. Foi aplicada uma força oclusal de 300N, dividida em cinco pontos (60 N cada) correspondentes ao contato oclusal de um primeiro molar superior. Foram observados os seguintes critérios de análise: tensão de cisalhamento, tensão principal máxima e mínima para o tecido ósseo e tensão de Von Mises para o implante e componentes protéticos. O uso de implantes de comprimento padrão reduziu a tensão de cisalhamento no osso cortical em 35,75% e no osso medular em 51% quando comparado aos implantes curtos. O comprimento do implante não afetou a concentração de tensão na restauração. A camada de cimento atuou reduzindo as tensões na cerâmica de cobertura e infraestrutura de cerâmica em 42%. Os implantes de tamanho padrão associados às coroas cimentadas apresentaram o melhor comportamento biomecânico.

Abstract The objective of this study was to compare the biomechanical behavior of peri-implant bone tissue and prosthetic components in two modalities of treatment for posterior region of the maxilla, using short implants or standard-length implants associated with bone graft in the maxillary sinus. Four 3D models of a crown supported by an implant fixed in the posterior maxilla were constructed. The type of implant: short implant (S) or standard-length implant with the presence of sinus graft (L) and type of crown retention: cemented (C) or screwed (S) were the study factors. The models were divided into SC- cemented crown on a short implant; SS- screwed crown on the short implant; LC- cemented crown on a standard-length implant after bone graft in the maxillary sinus and LS- crown screwed on a standard-length implant after bone graft in the maxillary sinus. An axial occlusal loading of 300 N was applied, divided into five points (60N each) corresponding to occlusal contact. The following analysis criteria were observed: Shear Stress, Maximum and Minimum Main Stress for bone tissue and von Mises Stress for the implant and prosthetic components. The use of standard-length implants reduced the shear stress in the cortical bone by 35.75% and the medullary bone by 51% when compared to short implants. The length of the implant did not affect the stress concentration in the crown, and the cement layer acted by reducing the stresses in the ceramic veneer and framework by 42%. Standard-implants associated with cemented crowns showed better biomechanical behavior.

Resumo: Este artigo explora a teoria das justificações para a análise das motivações e estratégias de atores da Agricultura Urbana e Periurbana (AUP) no estado de São Paulo, considerando perspectivas de desenvolvimento de seus territórios. Com uma abordagem cruzando sociologia e geografia, a pesquisa que ofereceu elementos de análise para a elaboração deste artigo fundamentou-se em entrevistas semiestruturadas, observações de campo e análise documental, considerando os casos do assentamento Milton Santos, situado parte em Americana, parte em Cosmópolis, assim como da Associação de Agricultores da Zona Leste da capital. O direito de acesso ao fundiário é absolutamente central para a AUP. A reivindicação deste direito, bem como a concepção de papéis das atividades compreendidas pela AUP, mobilizam referências de justiça com contornos ecológicos, o que oferece crescente legitimidade à causa, gerando diversos tipos de apoios. Porém, as evidências dos casos estudados indicam que a AUP está longe de ter sua perenidade e crescimento assegurados.

Abstract: This article explores the theory of justifications for the analysis of the motivations and strategies of actors in urban and peri-urban agriculture (UPA) in the state of São Paulo, considering perspectives for the development of their territories. With an approach crossing sociology and geography, the research which subsidized the elements brought to analysis in this article was based on a semi-structured interview, field observation, and documental analysis, considering the Milton Santos settlement in Americana and Cosmópolis and the Zona Leste Farmers Association in São Paulo city. The right of land access is central to the UPA. The claiming of this right, as well as the conception of the roles played by the practices concerning UPA, mobilize references of justice with ecological outlines, which offers increasing legitimacy to the cause, generating various types of support. However, the evidences of the studied cases point out that UPA is far from having a recognition that would ensure its perpetuity and growth.