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Resumo O envelhecimento tem impacto direto no equilíbrio devido a alterações da resposta sensorial e motora, sarcopenia e redução da força muscular e da amplitude de movimento que ocorre nos idosos. Nesse contexto, programas de treinamento de força (TF) são vistos como valiosa estratégia para minimizar o efeito deletério do envelhecimento na produção de força e no equilíbrio dessa população. O objetivo do estudo foi avaliar o efeito de 12 semanas de TF com intensidade progressiva sobre as variáveis de equilíbrio estático em idosos. Participaram do estudo 23 idosos com idade média de 65±8,61 anos, de ambos os sexos, que realizaram um programa de TF de doze semanas, com frequência de três vezes por semana e com intensidade progressiva (60 - 85% de 1-RM). O equilíbrio foi avaliado antes e após o período de intervenção, por meio de avaliação estabilométrica em plataforma de força. Após a intervenção houve redução na amplitude anteroposterior (p=0,01), na velocidade anteroposterior (p=0,01) e na área total deslocada (p= 0,04). Conclui-se que o treinamento de força pode ser utilizado como ferramenta chave para minimizar o efeito deletério do envelhecimento na manutenção do equilíbrio estático. motora contexto (TF população 1 2 65861 65 8 61 65±8,6 anos sexos 60 (6 85 1RM. 1RM RM . 1-RM) p=0,01, p001 p p=0,01 , 0 01 (p=0,01 p= (p 0,04. 004 0,04 04 0,04) Concluise Conclui se 6586 6 65±8, ( 1-RM p00 p=0,0 (p=0,0 00 0,0 658 65±8 p0 p=0, (p=0, 0, 65± p=0 (p=0

Abstract Aging has a direct impact on balance due to changes in sensory and motor response, sarcopenia, reduced muscle strength and range of motion that occur in the elderly. In this context, strength training (ST) programs are seen as a valuable strategy to minimize the deleterious effect of aging on strength production and balance in this population. The purpose of the study was to evaluate the effect of 12 weeks of progressive intensity ST on static balance variables in the elderly. The study included 23 elderly with an average age of 65±8.61 years, of both sexes, who performed a twelve-week strength training program, with a frequency of three times a week and with progressive intensity (60 - 85% of 1-RM). Balance was assessed before and after the intervention period, through stabilometric assessment on a force plate. After the intervention, there was a reduction in the anteroposterior amplitude (p=0.01), in the anteroposterior velocity (p=0.01) and in the total displaced area (p=0.04). It is concluded that the strength training can be used as a key tool to minimize the deleterious effect of aging on the maintenance of static balance. response sarcopenia context (ST population 1 2 65861 65 8 61 65±8.6 years sexes twelveweek twelve program 60 (6 85 1RM. 1RM RM . 1-RM) period plate p=0.01, p001 p p=0.01 , 0 01 (p=0.01 p=0.04. p004 p=0.04 04 (p=0.04) 6586 6 65±8. ( 1-RM p00 p=0.0 (p=0.0 (p=0.04 658 65±8 p0 p=0. (p=0. 65± p=0 (p=0 p= (p= (p

https://doi.org/10.1590/1980-0037.2024v26e86319

The Effects of Graphene Oxide and Iron Oxide (II) Co-addition on Properties of a Polypropylene/high-density Polyethylene Blend II (II Coaddition Co addition Polypropylene/highdensity Polypropylenehighdensity Polypropylene/high density Polypropylene high highdensity Polypropylenehigh
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Pietezak, Daniel Felipe

; Steffen, Teresa Tromm

; Fontana, Luis César

; Dalmolin, Carla

; Becker, Daniela

Materials Research

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2024, Volume 27 elocation e20230554

Abstract: En | Text: En | PDF: En

This study investigated the impact of adding graphene oxide (GO) and iron oxide (II) (Fe3O4) nanoparticles individually and in combination on the morphology, thermo-mechanical, and dielectric properties of a Polypropylene/High-Density Polyethylene (PP/HDPE) blend. By adding these nanoparticles separately or as a mixture, we can determine if both mechanisms have a synergistic effect and how they impact the dielectric constant values of their nanocomposites. The nanoparticle mixture was prepared in both an alkaline and a neutral medium. The mixture in the alkaline medium contained lower quantities of iron nanoparticles than in the neutral medium, and they were localized on the surface of GO. The nanocomposites showed significant differences in dynamic-mechanical and dielectric properties. The system with Fe3O4 exhibited a higher storage modulus, while the system with GO had a higher dielectric constant. However, no synergistic effect was observed in the nanoparticle mixtures. (GO II (II FeO Fe O (Fe3O4 morphology thermomechanical, thermomechanical thermo mechanical, mechanical thermo-mechanical Polypropylene/HighDensity PolypropyleneHighDensity Polypropylene/High Density Polypropylene High PP/HDPE PPHDPE PP HDPE (PP/HDPE blend dynamicmechanical dynamic Fe3O modulus However mixtures (Fe3O HighDensity PolypropyleneHigh

https://doi.org/10.1590/1980-5373-mr-2023-0554

First case of urban leishmaniasis in the Campeche State, Mexico State
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Blum-Domínguez, Selene

; Sánchez-Montes, Daniel Sokani

; Becker, Ingeborg

; García-Martínez, Rolando

; Tamay-Segovia, Paulino

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e58

Abstract: En | Text: En | PDF: En

ABSTRACT Cutaneous leishmaniasis represents 99% of all reported leishmaniasis cases in Mexico and typically occurs in agricultural or sylvatic areas. Campeche State is endemic for leishmaniasis; however, there are no previous records of urban Leishmania transmission. This report presents a case of cutaneous leishmaniasis in a 75-year-old man residing in an urban area. The patient presented with a three-month-old lesion on the right ear following an initial misdiagnosis of a bacterial infection. Given the suspicion of leishmaniasis, a tissue imprint was collected, revealing the presence of Leishmania amastigotes. Subsequently, amplification and sequencing of the Alanine aminotransferase and Internal transcribed spacer subunit 1 genes confirmed the presence of Leishmania mexicana. The patient was then treated with intralesional meglumine antimoniate. This case is significant as it marks the first confirmed human transmission of L. mexicana in an urban environment in Campeche State, demonstrating the importance of considering this pathology in patients with skin lesions originating from non-endemic areas in Mexico. 99 however 75yearold yearold 75 year old area threemonthold three month infection collected amastigotes Subsequently antimoniate L nonendemic non 9 7

https://doi.org/10.1590/s1678-9946202466058

Estratégias de comercialização da agricultura familiar durante a pandemia: visão de agricultores e consumidores da feira livre de Dom Pedrito-RS
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Maia, Joélio Farias

; Nascimento, Shirley Grazieli da Silva

; Hanke, Daniel

; Ávila, Mariana Rockenbach de

; Becker, Cláudio

Revista de Ciências Agrárias

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mar 2023, Volume 46 N. 1 Pages 11 - 20

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT The pandemic caused by COVID-19 had several impacts on society, especially on health, economic and access to food issues. In this sense, family farming plays an important role in food production, in addition to its socioeconomic contribution. The study aims to identify the marketing strategies of family farming during the pandemic period in the municipality of Dom Pedrito/RS. Methodologically, the study is a qualitative and descriptive research, carried out through interviews with family farmers and consumers in the municipality. To analyze the data collected, content analysis was used. The main results obtained in the study relate to the change in purchasing behavior on the part of consumers, who started to search for their food in fairs in rural properties, where forms of direct contact facilitate the commercialization and the use of technologies serves to subsidize the marketing of food, such as: phone calls, use of social networks and messaging applications, combined with the process of home delivery of purchases and also the need for public policies acting to mitigate the effects of the pandemic.

RESUMO A pandemia provocada pela COVID-19 acarretou diversos impactos na sociedade, com destaque para questões sanitárias, econômicas e de acesso à alimentação. Neste sentido, cabe a categoria agricultura familiar um importante papel na produção de alimentos, além de sua contribuição socioeconômica. O estudo tem como objetivo identificar as estratégias de comercialização da agricultura familiar durante o período de pandemia no município de Dom Pedrito/RS. Metodologicamente, o estudo trata-se de uma pesquisa de abordagem qualitativa e caráter descritivo, realizado através de entrevistas com agricultores familiares e consumidores do município. Para analisar os dados coletados, utilizou-se a análise de conteúdo. Os principais resultados obtidos no estudo dizem respeito à mudança no comportamento de compras por parte dos consumidores, que passaram a buscar seus alimentos em feiras nas propriedades rurais, onde formas de contato direto facilitam a comercialização e o uso de tecnologias serve para subsidiar a comercialização de alimentos, tais como: ligações telefônicas, utilização de redes sociais e aplicativos de mensagens, combinados ao processo de entrega de compras a domicílios e ainda a necessidade de políticas públicas atuando para mitigar os efeitos da pandemia.

https://doi.org/10.19084/rca.28437

Ciência da disseminação e implementação em países de língua portuguesa: por que considerar? portuguesa considerar
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Sala, Danila Cristina Paquier

; Okuno, Meiry Fernanda Pinto

; Buccini, Gabriela

; Hankins, Jane Silva

; Câmara, Alice Barros

; Vieira, Ana Claudia

; Horta, Ana Lucia de Moraes

; Varela, Andrea Liliana Vesga

; Trapé, Carla Andrea

; Treichel, Carlos Alberto dos Santos

; Luizaga, Carolina Terra de Moraes

; Oliveira, Cintia de Freitas

; Luquine Jr, Cézar D

; Bonfim, Daiana

; Melo, Daiane Sousa

; Fatori, Daniel

; Bernardo, Debora

; Silva, Flávio Dias

; Paiva Neto, Francisco Timbó de

; Sousa, Girliani Silva de

; Relvas, Gláubia Rocha Barbosa

; Eshriqui, Ilana

; Chavez, Leidy Janeth Erazo

; Almeida, Leticia Yamawaka de

; Godoi, Lídia Pereira da Silva

; Belotti, Lorrayne

; Corrêa, Lucas Hernandes

; Cordeiro, Luciana

; Hespanhol, Luiz

; Juskevicius, Luize Fábrega

; Padoveze, Maria Clara

; Bueno, Mariana

; Siqueira, Marina Martins

; Bortoli, Maritsa Carla de

; Louvison, Marília Cristina Prado

; Cardoso, Marília Mastrocolla de Almeida

; Becker, Natália

; Tanaka, Oswaldo Yoshimi

; Costa, Paula Cristina Pereira da

; Bomfim, Rafael Aiello

; Luz, Reginaldo Adalberto

; Gimbel, Sarah

; Dias, Sónia

; Castral, Thaíla Corrêa

; Domingos, Thiago da Silva

; Baumann, Ana A.

Acta Paulista de Enfermagem

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2023, Volume 36 Suppl. 1 elocation eEDT01

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.37689/acta-ape/2023edtspe01

Use of Diuretics is Associated with Higher Risk of Sarcopenia in Older Adults with Hypertension
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Martins Junior, Francisco de Assis Dias

; Mateo, Dahany Pamela Acta

; Silva, Fábio Junior de Miranda

; Moura, Samara Silva de

; Oliveira, Emerson Cruz

; Coelho, Daniel Barbosa

; Bearzoti, Eduardo

; Pinto, Kelerson Mauro de Castro

; Becker, Lenice Kappes

International Journal of Cardiovascular Sciences

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aug 2022, Volume 35 N. 4 Pages 476 - 485

Abstract: En | Text: En | PDF: En

Abstract Background: Sarcopenia is a disease that involves skeletal muscle mass loss and is highly prevalent in the older adult population. Moreover, the incidence of sarcopenia is increased in patients with hypertension. Objectives: The study aimed to evaluate the association between the classes of the drugs used for arterial hypertension treatment and the presence or absence of sarcopenia. Methods: 129 older adults with hypertension were evaluated by the researchers who registered the participants medication for arterial hypertension treatment. Sarcopenia level was measured by anthropometric parameters, muscular strength, and functional capacity. The data were analyzed by one-way ANOVA followed by post-hoc test and Fisher’s exact test; statistical significance was set at 0.05. Results: Age was not different between women with different levels of sarcopenia, but significant differences were observed between men with absent sarcopenia (66.8±4.2 years) and men with probable sarcopenia (77.0±10.2 years). Individuals with absent sarcopenia showed higher handgrip strength (men: 33.8±7.4, women: 23.2±4.6 Kgf) in comparison with those with sarcopenia (men with probable sarcopenia: 9.5±3.3 Kgf, women with probable, confirmed, and severe sarcopenia: 11.7±2.5, 12.2±3.0, 11.8±1.8 Kgf, respectively). The analysis showed an association between the type of medication and degree of sarcopenia; diuretics were significantly associated with probable sarcopenia, and angiotensin II receptor blockers (alone or in combination with diuretics) was associated with absence of sarcopenia. Conclusion: In conclusion, handgrip strength was a good method to diagnose sarcopenia, and diuretics were associated with increased risk of sarcopenia in older adults with hypertension.

https://doi.org/10.36660/ijcs.20200279

Recommendations by the Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and the Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) on vaccination in general and specifically against SARS-CoV-2 for patients with demyelinating diseases of the central nervous system
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Becker, Jefferson

; Ferreira, Lis Campos

; Damasceno, Alfredo

; Bichuetti, Denis Bernardi

; Christo, Paulo Pereira

; Callegaro, Dagoberto

; Peixoto, Marco Aurélio Lana

; Sousa, Nise Alessandra De Carvalho

; Almeida, Sérgio Monteiro De

; Adoni, Tarso

; Santiago-Amaral, Juliana

; Junqueira, Thiago

; Pereira, Samira Luisa Apóstolos

; Gomes, Ana Beatriz Ayroza Galvão Ribeiro

; Pitombeira, Milena

; Paolilo, Renata Barbosa

; Grzesiuk, Anderson Kuntz

; Piccolo, Ana Claudia

; D´Almeida, José Arthur Costa

; Gomes Neto, Antonio Pereira

; Oliveira, Augusto Cesar Penalva De

; Oliveira, Bianca Santos De

; Tauil, Carlos Bernardo

; Vasconcelos, Claudia Ferreira

; Kaimen-Maciel, Damacio

; Varela, Daniel

; Diniz, Denise Sisterolli

; Oliveira, Enedina Maria Lobato De

; Malfetano, Fabiola Rachid

; Borges, Fernando Elias

; Figueira, Fernando Faria Andrade

; Gondim, Francisco De Assis Aquino

; Passos, Giordani Rodrigues Dos

; Silva, Guilherme Diogo

; Olival, Guilherme Sciascia Do

; Santos, Gutemberg Augusto Cruz Dos

; Ruocco, Heloisa Helena

; Sato, Henry Koiti

; Soares Neto, Herval Ribeiro

; Cortoni Calia, Leandro

; Gonçalves, Marcus Vinícius Magno

; Vecino, Maria Cecilia Aragón De

; Pimentel, Maria Lucia Vellutini

; Ribeiro, Marlise De Castro

; Boaventura, Mateus

; Parolin, Mônica Koncke Fiuza

; Melo, Renata Brant De Souza

; Lázaro, Robson

; Thomaz, Rodrigo Barbosa

; Kleinpaul, Rodrigo

; Dias, Ronaldo Maciel

; Gomes, Sidney

; Lucatto, Simone Abrante

; Alves-Leon, Soniza Vieira

; Fukuda, Thiago

; Ribeiro, Taysa Alexandrino Gonsalves Jubé

; Winckler, Thereza Cristina D’ávila

; Fragoso, Yara Dadalti

; Nascimento, Osvaldo José Moreira Do

; Ferreira, Maria Lucia Brito

; Mendes, Maria Fernanda

; Brum, Doralina Guimarães

; Glehn, Felipe Von

Arquivos de Neuro-Psiquiatria

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nov 2021, Volume 79 N. 11 Pages 1049 - 1061

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O DC de Neuroimunologia da ABN e o BCTRIMS trazem, nesse documento, as recomendações sobre vacinação da população com doenças desmielinizantes do sistema nervoso central (SNC) contra infecções em geral e contra o coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2), causador da COVID-19. Destaca-se a gravidade do atual momento frente ao avanço da COVID-19 em nosso País, o que torna mais evidente e importante a criação de guia de referência para orientação aos médicos, pacientes e autoridades de saúde pública quanto à vacinação, meio efetivo e seguro no controle de determinadas doenças infecciosa. O DCNI/ABN e o BCTRIMS recomendam que os pacientes com doenças desmielinizantes do SNC (ex., EM e NMOSD) sejam constantemente monitorados, quanto a atualização do seu calendário vacinal, especialmente, no início ou antes da mudança do tratamento com uma droga modificadora de doença (DMD). É importante também salientar que as vacinas são seguras e os médicos devem estimular o seu uso em todos os pacientes. Evidentemente, deve ser dada especial atenção às vacinas com vírus vivos atenuados. Por fim, é importante que os médicos verifiquem qual DMD o paciente está em uso e quando foi feita a sua última dose, pois cada fármaco pode interagir de forma diferente com a indução da resposta imune.

ABSTRACT The Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) provide recommendations in this document for vaccination of the population with demyelinating diseases of the central nervous system (CNS) against infections in general and against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. We emphasize the seriousness of the current situation in view of the spread of COVID-19 in our country. Therefore, reference guides on vaccination for clinicians, patients, and public health authorities are particularly important to prevent some infectious diseases. The DCNI/ABN and BCTRIMS recommend that patients with CNS demyelinating diseases (e.g., MS and NMOSD) be continually monitored for updates to their vaccination schedule, especially at the beginning or before a change in treatment with a disease modifying drug (DMD). It is also important to note that vaccines are safe, and physicians should encourage their use in all patients. Clearly, special care should be taken when live attenuated viruses are involved. Finally, it is important for physicians to verify which DMD the patient is receiving and when the last dose was taken, as each drug may affect the induction of immune response differently.

https://doi.org/10.1590/0004-282x-anp-2021-0162 1 downloads

Prevalence of multiple sclerosis in key cities of Brazil: a study in Passo Fundo, Southern Brazil
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Passos, Giordani Rodrigues dos

; Becker, Jefferson

; Varela, Daniel Lima

; Fröhlich, Alan Christmann

; Rech, Bruna Constantino

; Mattos, Ana Carolina Squeff de

; Callegaro, Dagoberto

; Lana-Peixoto, Marco Aurélio

Arquivos de Neuro-Psiquiatria

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aug 2021, Volume 79 N. 8 Pages 692 - 696

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: Para melhor comparar a prevalência de esclerose múltipla (EM) nas diferentes regiões do Brasil, o Comitê Brasileiro para Tratamento e Pesquisa em Esclerose Múltipla implementou uma abordagem padronizada para avaliar a prevalência da doença em 5 cidades-chave, consideradas representativas de suas regiões em termos de características sociogeográficas e nas quais seria viável revisar cada caso pessoalmente. Objetivos: Descrever a prevalência pontual de EM em Passo Fundo, uma das cidades-chave, localizada no Sul do Brasil. Métodos: Buscamos identificar todos os pacientes com EM que viviam em Passo Fundo no dia 1( de julho de 2015. A fonte primária para identificação de casos foi os registros de consultórios de neurologistas e neurocirurgiões da cidade. Múltiplas fontes secundárias foram usadas para maximizar a identificação de casos. Todos os pacientes tiveram o diagnóstico revisado pessoalmente por um painel de neurologistas com experiência em EM. Resultados: Identificamos 52 pacientes com EM que viviam em Passo Fundo em 1( de julho de 2015. Assim, a prevalência pontual bruta de EM foi 26,4/100.000 habitantes (intervalo de confiança de 95%, 19,7 a 34,6/100.000). Entre os casos de EM, 42 (80,8%) eram mulheres, (razão de sexos: 4,2:1). Quarenta e seis casos (88,5%) foram categorizados como EM remitente-recorrente, e os 6 casos restantes como EM secundariamente progressiva (11,5%). As demais características epidemiológicas e clínicas foram comparáveis a populações de EM internacionais. Conclusões: A prevalência de EM em Passo Fundo é uma das maiores já relatadas no Brasil. Estudos em outras cidades-chave brasileiras, usando a mesma metodologia, estão em andamento.

ABSTRACT Background: To improve the comparability of multiple sclerosis (MS) prevalence across Brazilian regions, the Brazilian Committee for Treatment and Research in MS has implemented a standardized approach to assess the prevalence of the disease in five key cities, which were deemed representative of their regions in terms of socio-geographical features and where in-person revision of each case was feasible. Objective: To report the point-prevalence of MS in Passo Fundo, one of the key cities in Southern Brazil. Methods: We sought to identify all MS patients who were living in Passo Fundo on July 1st, 2015. The primary source for case ascertainment was records from the offices of neurologists and neurosurgeons practicing in the city. Multiple secondary sources were used to maximize identification of cases. All patients underwent in-person review of the diagnosis by a panel of neurologists with experience in MS. Results: We identified 52 MS patients living in Passo Fundo on July 1st, 2015. The point-prevalence rate for MS was 26.4/100,000 population (95% confidence interval, 19.7 to 34.6/100,000). Among the MS cases, 42 (80.8%) were female, for a sex ratio of 4.2:1. Forty-six cases (88.5%) were categorized as relapsing-remitting MS, and the remaining 6 cases, as secondary progressive MS (11.5%). Other epidemiological and clinical features were comparable to national and international MS populations. Conclusions: The prevalence of MS in Passo Fundo is one of the highest reported in Brazil so far. Studies in other key Brazilian cities, using the same methodology, are currently being carried out.

https://doi.org/10.1590/0004-282x-anp-2020-0221 182 downloads

Caracterización clínica y microbiológica de episodios de bacteriemia por Streptococcus grupo viridans en niños con cáncer y neutropenia febril de alto riesgo
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Cortés, Daniel

; Maldonado, María Eliana

; Rivacoba, María Carolina

; Maza, Verónica de la

; Valenzuela, Romina

; Payá, Ernesto

; Contardo, Verónica

; Álvarez, Ana María

; Avilés, Carmen Luz

; Becker, Ana

; Salgado, Carmen

; Tordecilla, Juan

; Varas, Mónica

; Venegas, Marcela

; Villarroel, Milena

; Viviani, Tamara

; Zubieta, Marcela

; Santolaya, María Elena

Revista chilena de infectología

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aug 2020, Volume 37 N. 4 Pages 383 - 388

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Background: Viridans group streptococci (VGS) has acquired relevance as a microorganism causing febrile neutropenia, associated with significant morbidity. Aim: To characterize episodes of bacteremia caused by VGS in children with cancer who developed high-risk febrile neutropenia (HRFN) during the period from April 2004 to June 2018 in six pediatric hospitals of Santiago, Chile. Method: Database analysis of 4 successive, prospective and multicentric studies recording clinical and laboratory characteristics of patients, as well as antimicrobial susceptibility pattern of isolated strains. Results: 95 episodes of VGS bacteremia in 91 children with HRFN were analyzed. It emphasizes acute myeloid leukemia as cancer type, deep neutropenia, prolonged hospitalization (15 days), with extended use of antimicrobials (14 days) and use of cytarabine in chemotherapy schemes (86% episodes). The most frequent clinical manifestations were respiratory and gastrointestinal, associating up to 26% viridans group shock syndrome. There was high resistance to β lactams. As expected, there were not non-susceptible strains to vancomycin. Discussion: VGS is a relevant microorganism in children with cancer, fever and neutropenia, with a high percentage of sepsis. Resistance to β lactams is an issue that requires strict epidemiological surveillance in this population.

Resumen Introducción: Streptococcus grupo viridans (SGV) ha adquirido relevancia como microorganismo causante de neutropenia febril, asociándose a morbilidad significativa. Objetivo: Caracterizar episodios de bacteriemia causados por SGV en niños con cáncer que desarrollaron neutropenia febril de alto riesgo (NFAR) desde abril de 2004 a junio de 2018 en seis hospitales pediátricos de Santiago, Chile. Pacientes y Métodos: Análisis retrospectivo de bases de datos de cuatro proyectos FONDECYT sucesivos, prospectivos y multicéntricos, registrando características clínicas y de laboratorio de los pacientes, además de patrón de resistencia antimicrobiana de las cepas aisladas. Resultados: Se registraron 95 episodios de bacteriemia asociada a SGV en 91 niños con NFAR. Destacan: leucemia mieloide aguda como enfermedad de base, neutropenia profunda, hospitalización prolongada (15 días), uso extendido de antimicrobianos (14 días), uso de citarabina en esquemas de quimioterapia (86% episodios). Las manifestaciones clínicas más frecuentes fueron respiratoria y gastrointestinal, asociándose en 26% a síndrome de shock por Streptococcus grupo viridans. Hubo elevada resistencia a β lactámicos, sin cepas no susceptibles a vancomicina. Discusión: SGV es un patógeno relevante en niños con cáncer, fiebre y neutropenia en nuestro medio, asociado a casos de sepsis. La resistencia a β lactámicos es un aspecto que requiere vigilancia epidemiológica estricta en esta población.

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Physical exercise improves body weight gain and liver function in malnourished rats without disturbing the redox balance
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OLIVEIRA, Emerson Cruz de

; SANTOS, Rinaldo Cardoso dos

; BECKER, Lenice Kappes

; COELHO, Daniel Barbosa

; PEDROSA, Maria Lúcia

; SILVA, Marcelo Eustáquio

Revista de Nutrição

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oct 2018, Volume 31 N. 5 Pages 443 - 453

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo Estudar a relação entre exercício e desnutrição, pois evidências recentes sugerem que o exercício físico pode causar a adaptação benéfica de sistemas antioxidantes, enquanto a desnutrição pode causar adaptação prejudicial a esses sistemas. Métodos Trinta e duas ratas Fischer foram igualmente divididas nos grupos Controle Sedentário, Controle Treinado, Desnutrido Sedentário e Desnutrido Treinado. O protocolo de treinamento consistiu em nadar por 30 minutos continuamente por 5 dias/semana por 8 semanas. Resultados Demonstramos que as atividades de aspartato aminotransferase e alanina aminotransferase aumentaram em ratos desnutridos, mas o treinamento físico reverteu esses efeitos. O nível de glutationa foi diminuído pela desnutrição, enquanto o treinamento físico aumentou os níveis de proteína carbonilada do fígado e aumentou os níveis de substâncias reativas ao ácido tiobarbitúrico que foram diminuídas pela desnutrição. Além disso, os ratos desnutridos treinados tiveram um peso corporal médio maior que os desnutridos sedentários (62,77g vs 55,08g, respectivamente). Conclusão Os dados mostram que o exercício foi capaz de reverter ou reduzir os danos causados pela desnutrição, como perda de peso e a disfunção hepática por uma via independente da participação de enzimas envolvidas na defesa antioxidante e que não há interação entre exercício e desnutrição.

ABSTRACT Objective To study the relationship between exercise and malnourishment because recent evidence suggests that exercise can cause the beneficial adaptation of antioxidant systems, whereas malnourishment can cause harmful adaptation of these systems. Methods Thirty-two female Fischer rats were equally divided into Sedentary Control, Trained Control, Sedentary Malnourished and Trained Malnourished groups. The training protocol consisted of swimming for 30 minutes continuously for 5 days/week for 8 weeks. Results It was demonstrated that aspartate aminotransferase and alanine aminotransferase activities increased in malnourished rats, but physical training reversed these effects by lowering the raised levels. The glutathione level was diminished by malnourishment whereas physical training increased the levels of liver carbonyl protein and increased the levels of thiobarbituric acid reactive substances that were diminished by malnourishment. In addition, Trained Malnourished rats had a higher average body weight than Sedentary Malnourished ones (62.77g vs. 55.08g, respectively). Conclusion The data show that exercise was able to reverse or reduce damage caused by malnourishment, such as weight loss and liver dysfunction by a pathway independent of the participation of enzymes involved in antioxidant defense and that there is no interaction between exercise and malnutrition.

https://doi.org/10.1590/1678-98652018000500002 1085 downloads

11.

Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism
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Rech, Tássia Flores

; Mazzoleni, Luiz Edmundo

; Mazzoleni, Felipe

; Francesconi, Carlos Fernando de Magalhães

; Sander, Guilherme Becker

; Michita, Rafael Tomoya

; Nabinger, Débora Dreher

; Milbradt, Tobias Cancian

; Torresini, Ronaldo João Spinato

; Simon, Daniel

Brazilian Journal of Infectious Diseases

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aug 2018, Volume 22 N. 4 Pages 311 - 316

Abstract: En | Text: En | PDF: En

ABSTRACT Aim To analyze the influence of the -31 C/T polymorphism of the interleukin-1β gene on Helicobacter pylori eradication therapy success in patients with functional dyspepsia. Methods Functional dyspepsia was diagnosed according to the Rome III criteria. All patients underwent upper gastrointestinal endoscopy, and gastric biopsies were obtained at screening and 12 months after randomization (last follow-up visit). Urease test and histological examination were performed to define the H. pylori status. Patients received twice-daily amoxicillin, clarithromycin and omeprazole for 10 days. Genotyping of the interleukin-1beta -31 C/T polymorphism (rs1143627) was performed using polymerase chain reaction-restriction fragment length polymorphism. Results One hundred forty-nine patients received treatment with triple therapy for H. pylori eradication. Only one patient was lost to follow-up, and adherence to study medication was 94.6%. A total of 148 patients (mean age 46.08 ± 12.24 years; 81.8% women) were evaluated for the influence of the interleukin-1beta -31 C/T polymorphism on the outcome of H. pylori eradication therapy. After treatment, bacteria were eradicated in 87% of patients (129/148). Genotype frequencies of the polymorphism were as follows: CC, 38/148 (25.7%); CT, 71/148 (47.9%); and TT, 39/148 (26.4%). Successful eradication rate was 78.9%, 94.4% and 82.1% for the CC, CT and TT genotypes, respectively. The CT genotype was significantly associated with successful H. pylori eradication (p= 0.039). Conclusion This study suggests that the CT genotype of the interleukin-1beta -31 C/T polymorphism plays a role in the successful eradication of H. pylori among patients with functional dyspepsia.

https://doi.org/10.1016/j.bjid.2018.06.005 638 downloads

12.

The association between adult-type hypolactasia and symptoms of functional dyspepsia
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Wortmann, André Castagna

; Simon, Daniel

; Mazzoleni, Luiz Edmundo

; Sander, Guilherme Becker

; Francesconi, Carlos Fernando de Magalhães

; Nabinger, Débora Dreher

; Grott, Camila Schultz

; Rech, Tássia Flores

; Mazzoleni, Felipe

; Lunge, Vagner Ricardo

; Bona, Laura Renata de

; Milbradt, Tobias Cancian

; Silveira, Themis Reverbel da

Genetics and Molecular Biology

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mar 2018, Volume 41 N. 1 Pages 92 - 97

Abstract: En | Text: En | PDF: En

Abstract Functional dyspepsia and lactose intolerance (adult-type hypolactasia, ATH) are common conditions that may coexist or even be confounded. Their clinical presentation can be similar, however, lactose intolerance does not form part of the diagnostic investigation of functional dyspepsia. Studies on the association between functional dyspepsia and ATH are scarce. This study aimed to evaluate whether ATH is associated with symptoms of functional dyspepsia. Patients fulfilling the Rome III diagnostic criteria for functional dyspepsia underwent genetic testing for ATH. Dyspeptic symptoms were evaluated and scored according to a validated questionnaire. The diagnostic criteria for ATH was a CC genotype for the -13910C/T polymorphism, located upstream of the lactase gene. The mean scores for dyspeptic symptoms were compared between patients with ATH and those with lactase persistence. A total of 197 functional dyspeptic patients were included in the study. Mean age was 47.7 years and 82.7% patients were women. Eighty-eight patients (44.7%) had a diagnosis of ATH. Abdominal bloating scores were higher in ATH patients compared to the lactase persistent patients (P=0.014). The remaining dyspeptic symptom scores were not significantly different between the two groups. The study results demonstrate an association between ATH and bloating in patients with functional dyspepsia.

https://doi.org/10.1590/1678-4685-gmb-2017-0015 1119 downloads

13.

Magnetic resonance imaging of fibroadenoma-like lesions and correlation with Breast Imaging-Reporting and Data System and Kaiser scoring system
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Cloete, Daniel J.

; Minne, Cornelia

; Schoub, Peter K.

; Becker, Jan H.R

SA Journal of Radiology

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2018, Volume 22 N. 2 Pages 1 - 9

Abstract: En | Text: En | PDF: En

BACKGROUND: Multiple breast lesions resembling fibroadenomas are a common imaging finding in patients presenting to the mammography unit at Dr George Mukhari Academic Hospital in the North-West district of Tshwane, South Africa. Patients often present with multiple lesions, up to 20 lesions per breast. These lesions often have atypical features on ultrasound and/or a clinical history of growth is commonly given. Phyllodes tumours may be indistinguishable from fibroadenomas and breast cancers may on occasion present with benign features, which can lead to misdiagnosis. Breast magnetic resonance imaging (bMRI) evaluation of lesions resembling fibroadenomas may improve accurate assessment and identification of lesions requiring biopsy. OBJECTIVES: To assess the reliability of bMRI to characterise lesions resembling fibroadenomas on ultrasound, using the Breast Imaging-Reporting and Data System (BI-RADS) and Kaiser scoring systems with histopathological correlation. METHOD: A quantitative, prospective, investigative study was performed with a sample size of 100 breast lesions among a total of 35 patients at Dr George Mukhari Academic Hospital. Patients were recruited after a breast ultrasound investigation revealed lesions resembling fibroadenomas, but with an indication for ultrasound-guided biopsy, for example, very large size, atypical features on ultrasound or a history of recent growth. The bMRI was performed prior to the ultrasound-guided breast biopsies. Three investigators independently evaluated the bMRI and applied BI-RADS descriptors to each lesion. The Kaiser score was then calculated for each lesion. Statistics were calculated using Pearson's and Spearman's coefficients for inter-reader variability, kappa scores for BI-RADS and Kaiser score correlation with histology. RESULTS: Evaluation with bMRI, BI-RADS and the Kaiser scoring system showed statistically significant correlation with each other and with histopathology results for each lesion. There was statistically significant agreement among the investigators regarding the interpretation of the lesions and allocation of appropriate BI-RADS scores. CONCLUSION: Multiple lesions resembling fibroadenomas can be evaluated with bMRI when multiple breast biopsies would not be feasible. With a good imaging protocol and technique, adequate interpretation skills by the radiologist and the use of the Kaiser scoring system, an accurate diagnosis can be achieved.

https://doi.org/10.4102/sajr.v22i2.1532 284 downloads

14.

Langerhans’ cell histiocytosis diagnosed due to dermatological perianal lesion
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Scolaro, Bruno Lorenzo

; Pereira, Gustavo Becker

; Ogata, Daniel Cury

; Cunha, Fernanda Souto Padrón Figueiredo Vieira da

; Effting, Ana Cristina Martins

; Guanabara, Rafael Oselame

Journal of Coloproctology (Rio de Janeiro)

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sep 2017, Volume 37 N. 3 Pages 242 - 246

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A histiocitose de células de Langerhans é uma doença rara caracterizada pela proliferação de células de Langerhans no corpo. A doença afeta principalmente os homens, predominantemente na infância. Placas ulceradas são uma das formas cutâneas de apresentação. A confirmação diagnóstica é feita através de análise imuno-histoquímica. Como opções terapêuticas, corticosteroides tópicos e quimioterapia são boas escolhas. O caso aqui relatado é de um paciente do sexo masculino, com idade de 14 anos, com ulceração perianal. Ele consultou um coloproctologista, que realizou uma biópsia da região e iniciou o tratamento com aplicações locais de triancinolona. A análise imunohistoquímica diagnosticou histiocitose de células de Langerhans. Outros exames revelaram diabetes insipidus, lesões osteolíticas no crânio e nos membros inferiores, aumento do fígado e alterações encefálicas. A quimioterapia foi iniciada com vimblastina, com melhora significativa das lesões.

Abstract Langerhans’ cell histiocytosis is a rare disease characterized by proliferation of Langerhans cells in the body. It affects mainly males, predominantly in childhood. Ulcerated plaques are one of the cutaneous forms of presentation. Diagnostic confirmation is done through immunohistochemistry. As therapeutic options, topical corticosteroids and chemotherapy are good choices. The case is reported of a male patient, aged 14, with perianal ulceration. He consulted a coloproctologist, who performed a biopsy of the region and started local triamcinolone applications. Immunohistochemistry diagnosed Langerhans’ cells histiocytosis. Further investigation revealed diabetes insipidus, osteolytic lesions in the skull and lower limbs, enlarged liver, and encephalic alterations. Chemotherapy was started with Vinblastine, with significant improvement of the lesions.

https://doi.org/10.1016/j.jcol.2017.03.007 1158 downloads

15.

Resultados de un programa nacional de trasplante cardiaco pediátrico: fortalezas y debilidades
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Becker, Pedro

; Besa, Santiago

; Riveros, Sergio

; González, Rodrigo

; Navia, Alfonso

; Dellepiane, Paulina

; Springmuller, Daniel

; Urcelay, Gonzalo

Revista chilena de pediatría

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jun 2017, Volume 88 N. 3 Pages 367 - 376

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Pediatric heart transplantation is an effective therapy to treat advanced heart failure in children. Objectives: To analyze the immediate and mid-term results of pediatric patients listed for heart transplantation. Patients and Methods: Registration of patients admitted to our transplant protocol between October 2001 and July 2016 were reviewed, analyzing demographic data, diagnosis, status at the time of listing, waiting time until transplantation, donor data, use of ventricular assist device, hemodynamic data, complications and global mortality. Results: Thirthy patients where included with a mean age of 9.4 years (1 month to 15 years). The most frequent diagnosis was dilated cardiomyopathy in 24 patients (80%). The status was I (urgency) in 19 cases and II in 11 cases. Ten patients died on the waiting list (33.3%) at an average of 52 days (13-139 days). Fourteen were transplanted (46.7%), with a waiting time of 199.6 days (4-586 days). Nine patients required mechanical support (30%). All patients received triple association of immunosuppression. One patient died 16 days post transplant due to primary graft failure (7.1%). The average follow-up was 43 months (0.5-159 months). Two patients died later on (82 and 55 months), both due to secondary rejection because of voluntary cessation of immunosuppressive therapy. Survival at 1 and 5 years was 93% and 74%, respectively. Conclusions: Our program has successfully transplanted 50% of patients enrolled, with good medium-term survival. A significant proportion of patients were listed as a medical emergency and 34.5% died on the waiting list.

El trasplante cardiaco pediátrico es una terapia efectiva para tratar la insuficiencia cardiaca avanzada. Objetivos: Analizar los resultados inmediatos y a mediano plazo de niños enlistados para trasplante cardiaco. Pacientes y Método: Se analizó el registro de pacientes enlistados para trasplante, entre octubre de 2001 y julio de 2016, analizando datos demográficos, diagnósticos, status de enlistamiento, tiempo de espera, datos de donantes, uso de asistencia ventricular, complicaciones y mortalidad. Resultados: La serie abarca 30 pacientes con edad promedio de 9,4 años (1 mes a 15 años). El diagnóstico principal fue miocardiopatía dilatada en 24 pacientes (80%). El status de ingreso fue I (urgencia) en 19 casos y II (no urgencia) en 11. Fallecieron 10 en la lista de espera (33,3%) en un promedio de 52 días (13 a 139 días). Catorce pacientes fueron trasplantados (46.7%), con un tiempo de espera de 199,6 días (4 a 586 días). Requirieron asistencia ventricular 9 pacientes (30%). Todos recibieron inmunosupresión tri asociada. Un paciente falleció a los 16 días por falla primaria del injerto (7,1%). El seguimiento promedio fue de 43 meses (0,5 a 159 meses). Dos pacientes fallecieron alejadamente (55 y 82 meses) por rechazo secundario al abandono de tratamiento inmunosupresor. La supervivencia a 1 y 5 años fue 93% y 74%, respectivamente. Conclusiones: Nuestro programa ha trasplantado al 50% de los pacientes enlistados con buena supervivencia a mediano plazo. Una proporción significativa de pacientes se enlistó con carácter de urgencia y un 34.5% de los pacientes fallecieron en la lista de espera.

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