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RESUMO Contexto: Em estudos observacionais sobre a síndrome do desconforto respiratório agudo, sugeriu-se que a driving pressure é o principal fator de lesão pulmonar induzida por ventilador e de mortalidade. Não está claro se uma estratégia de limitação da driving pressure pode melhorar os desfechos clínicos. Objetivo: Descrever o protocolo e o plano de análise estatística que serão usados para testar se uma estratégia de limitação da driving pressure envolvendo a titulação da pressão positiva expiratória final de acordo com a melhor complacência respiratória e a redução do volume corrente é superior a uma estratégia padrão envolvendo o uso da tabela de pressão positiva expiratória final baixa do protocolo ARDSNet, em termos de aumento do número de dias sem ventilador em pacientes com síndrome do desconforto respiratório agudo devido à pneumonia adquirida na comunidade. Métodos: O estudo STAMINA (ventilator STrAtegy for coMmunIty acquired pNeumoniA) é randomizado, multicêntrico e aberto e compara uma estratégia de limitação da driving pressure com a tabela de pressão positiva expiratória final baixa do protocolo ARDSnet em pacientes com síndrome do desconforto respiratório agudo moderada a grave devido à pneumonia adquirida na comunidade internados em unidades de terapia intensiva. Esperamos recrutar 500 pacientes de 20 unidades de terapia intensiva brasileiras e duas colombianas. Eles serão randomizados para um grupo da estratégia de limitação da driving pressure ou para um grupo de estratégia padrão usando a tabela de pressão positiva expiratória final baixa do protocolo ARDSnet. No grupo da estratégia de limitação da driving pressure, a pressão positiva expiratória final será titulada de acordo com a melhor complacência do sistema respiratório. Desfechos: O desfecho primário é o número de dias sem ventilador em 28 dias. Os desfechos secundários são a mortalidade hospitalar e na unidade de terapia intensiva e a necessidade de terapias de resgate, como suporte de vida extracorpóreo, manobras de recrutamento e óxido nítrico inalado. Conclusão: O STAMINA foi projetado para fornecer evidências sobre se uma estratégia de limitação da driving pressure é superior à estratégia da tabela de pressão positiva expiratória final baixa do protocolo ARDSnet para aumentar o número de dias sem ventilador em 28 dias em pacientes com síndrome do desconforto respiratório agudo moderada a grave. Aqui, descrevemos a justificativa, o desenho e o status do estudo. Contexto sugeriuse sugeriu clínicos Objetivo ARDSNet Métodos ventilator pNeumoniA randomizado 50 2 colombianas Desfechos resgate extracorpóreo inalado Conclusão Aqui justificativa 5

ABSTRACT Background: Driving pressure has been suggested to be the main driver of ventilator-induced lung injury and mortality in observational studies of acute respiratory distress syndrome. Whether a driving pressure-limiting strategy can improve clinical outcomes is unclear. Objective: To describe the protocol and statistical analysis plan that will be used to test whether a driving pressure-limiting strategy including positive end-expiratory pressure titration according to the best respiratory compliance and reduction in tidal volume is superior to a standard strategy involving the use of the ARDSNet low-positive end-expiratory pressure table in terms of increasing the number of ventilator-free days in patients with acute respiratory distress syndrome due to community-acquired pneumonia. Methods: The ventilator STrAtegy for coMmunIty acquired pNeumoniA (STAMINA) study is a randomized, multicenter, open-label trial that compares a driving pressure-limiting strategy to the ARDSnet low-positive end-expiratory pressure table in patients with moderate-to-severe acute respiratory distress syndrome due to community-acquired pneumonia admitted to intensive care units. We expect to recruit 500 patients from 20 Brazilian and 2 Colombian intensive care units. They will be randomized to a driving pressure-limiting strategy group or to a standard strategy using the ARDSNet low-positive end-expiratory pressure table. In the driving pressure-limiting strategy group, positive end-expiratory pressure will be titrated according to the best respiratory system compliance. Outcomes: The primary outcome is the number of ventilator-free days within 28 days. The secondary outcomes are in-hospital and intensive care unit mortality and the need for rescue therapies such as extracorporeal life support, recruitment maneuvers and inhaled nitric oxide. Conclusion: STAMINA is designed to provide evidence on whether a driving pressure-limiting strategy is superior to the ARDSNet low-positive end-expiratory pressure table strategy for increasing the number of ventilator-free days within 28 days in patients with moderate-to-severe acute respiratory distress syndrome. Here, we describe the rationale, design and status of the trial. Background ventilatorinduced induced pressurelimiting limiting unclear Objective endexpiratory end expiratory lowpositive low ventilatorfree free communityacquired community Methods (STAMINA multicenter openlabel open label moderatetosevere moderate severe units 50 Outcomes inhospital hospital support oxide Conclusion Here rationale 5

https://doi.org/10.62675/2965-2774.20240210-en

COVID-19 in hematopoietic stem cell transplant recipients during three years of the pandemic: a multicenter study in Brazil COVID19 COVID 19 COVID-1 pandemic COVID1 1 COVID-
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Randi, Bruno Azevedo

; Higashino, Hermes Ryoiti

; Silva, Vinícius Ponzio da

; Salomão, Matias Chiarastelli

; Pignatari, Antonio Carlos Campos

; Abdala, Edson

; Vasques, Fabiana

; Silva, Celso Arrais Rodrigues da

; Silva, Roberto Luiz da

; Lazari, Carolina dos Santos

; Levi, José Eduardo

; Xavier, Erick Menezes

; Côrtes, Marina Farrel

; Luna-Muschi, Alessandra

; Rocha, Vanderson

; Costa, Silvia Figueiredo

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e17

Abstract: En | Text: En | PDF: En

ABSTRACT Hematopoietic stem cell transplant (HSCT) recipients are at -increased risk for severe COVID-19. The aim of this study was to evaluate the burden of COVID-19 in a cohort of HSCT recipients. This retrospective study evaluated a cohort of adult hospitalized HSCT recipients diagnosed with COVID-19 in two large hospitals in São Paulo, Brazil post-HSCT, from January 2020 to June 2022. The primary outcome was all-cause mortality. Of 49 cases, 63.2% were male with a median age of 47 years. Allogeneic-HSCT (51.2%) and autologous-HSCT (48.9%) patients were included. The median time from HSCT to COVID-19 diagnosis was 398 days (IQR: 1211-134), with 22 (44.8%) cases occurring within 12 months of transplantation. Most cases occurred during the first year of the pandemic, in non-vaccinated patients (n=35; 71.4%). Most patients developed severe (24.4%) or critical (40.8%) disease; 67.3% received some medication for COVID-19, primarily corticosteroids (53.0%). The probable invasive aspergillosis prevalence was 10.2%. All-cause mortality was 40.8%, 51.4% in non-vaccinated patients and 14.2% in patients who received at least one dose of the vaccine. In the multiple regression analyses, the variables mechanical ventilation (OR: 101.01; 95% CI: 8.205 – 1,242.93; p = 0.003) and chest CT involvement at diagnosis ≥50% (OR: 26.61; 95% CI: 1.06 – 664.26; p = 0.04) remained associated with all-cause mortality. Thus, HSCT recipients with COVID-19 experienced high mortality, highlighting the need for full vaccination and infection prevention measures. (HSCT increased COVID19. COVID19 COVID 19. 19 COVID-1 Paulo postHSCT, postHSCT post HSCT, post-HSCT 202 2022 allcause all cause 4 632 63 2 63.2 years AllogeneicHSCT Allogeneic 51.2% 512 51 (51.2% autologousHSCT autologous 48.9% 489 48 9 (48.9% included 39 IQR (IQR 1211134, 1211134 1211 134 , 1211-134) 44.8% 448 44 8 (44.8% 1 transplantation pandemic nonvaccinated non vaccinated n=35 n35 n 35 (n=35 71.4%. 714 71.4% . 71 71.4%) 24.4% 244 24 (24.4% 40.8% 408 40 (40.8% disease 673 67 3 67.3 COVID19, 19, 53.0%. 530 53.0% 53 0 (53.0%) 102 10 10.2% Allcause All 514 51.4 142 14 14.2 vaccine analyses OR (OR 101.01 10101 101 01 95 CI 8205 205 8.20 1,242.93 124293 242 93 0.003 0003 003 50 ≥50 26.61 2661 26 61 106 06 1.0 664.26 66426 664 0.04 004 04 Thus measures COVID1 COVID- 20 6 63. 51.2 5 (51.2 48.9 (48.9 121113 121 13 1211-134 44.8 (44.8 n=3 n3 (n=3 71.4 7 24.4 (24.4 40.8 (40.8 67. 53.0 (53.0% 10.2 51. 14. 101.0 1010 820 8.2 1,242.9 12429 0.00 000 00 ≥5 26.6 266 1. 664.2 6642 66 0.0 (51. 48. (48. 12111 1211-13 44. (44. n= (n= 71. 24. (24. 40. (40. 53. (53.0 10. 101. 82 8. 1,242. 1242 ≥ 26. 664. 0. (51 (48 1211-1 (44 (n (24 (40 (53. 1,242 124 (5 (4 1211- (2 (53 1,24 ( 1,2 1,

https://doi.org/10.1590/s1678-9946202466017

Diferenças entre homens e mulheres na prevalência da fragilidade e fatores associados entre adultos mais velhos: evidências do ELSI-Brasil velhos ELSIBrasil ELSI Brasil
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Silva, Silvia Lanziotti Azevedo da

; Brito, Geraldo Eduardo Guedes de

; Ygnatios, Nair Tavares Milhem

; Mambrini, Juliana Vaz de Melo

; Lima-Costa, Maria Fernanda

; Torres, Juliana Lustosa

Cadernos de Saúde Pública

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2024, Volume 40 N. 3 elocation e00144923

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Este trabalho, baseado em amostra nacional representativa da população com 50 anos ou mais, objetivou estimar a prevalência da fragilidade entre homens e mulheres, identificar fatores sociodemográficos e de saúde associados e estimar a fração atribuível populacional. Foram utilizados dados da segunda onda (2019-2021) do Estudo Longitudinal da Saúde dos Idosos Brasileiros (ELSI-Brasil). A fragilidade foi classificada pelo número de itens positivos entre perda de peso não intencional, exaustão, baixo nível de atividade física, lentidão da marcha e fraqueza. As análises principais foram baseadas na regressão logística multinomial estratificada por sexo. A prevalência da fragilidade foi menor nos homens (8,6%; IC95%: 6,9; 10,7) do que nas mulheres (11,9%; IC95%: 9,6; 14,8), sendo o item mais frequente o baixo nível de atividade física em ambos. A idade e a escolaridade foram os fatores sociodemográficos associados à pré-fragilidade e à fragilidade entre homens e mulheres. Houve diferença da fração atribuível populacional para fragilidade entre os sexos. Nos homens, a maior fração atribuível populacional foi para não ter companheiro (23,5%; IC95%: 7,7; 39,2) e escolaridade baixa (18,2%; IC95%: 6,6; 29,7). Nas mulheres, maiores frações atribuíveis populacionais foram para déficit de memória (17,1%; IC95%: 7,6; 26,6), déficit da visão (13,4%; IC95%: 5,1; 21,7) e diabetes mellitus (11,4%; IC95%: 4,6; 18,1). Observou-se fração atribuível populacional semelhante para doença cardíaca (8,9%; IC95%: 3,8; 14,1, em mulheres; e 8,8%; IC95%: 2,0; 15,6, em homens). Estratégias voltadas para a prática de atividade física têm o potencial de prevenir a fragilidade em ambos os sexos, enquanto a prevenção de condições crônicas é mais importante nas mulheres. trabalho 5 20192021 2019 2021 (2019-2021 ELSIBrasil. ELSIBrasil ELSI Brasil . (ELSI-Brasil) intencional exaustão fraqueza sexo 8,6% 86 8 6 (8,6% IC95% IC95 IC 6,9 69 9 10,7 107 10 7 11,9% 119 11 (11,9% 9,6 96 14,8, 148 14,8 , 14 14,8) préfragilidade pré sexos 23,5% 235 23 (23,5% 7,7 77 39,2 392 39 2 18,2% 182 18 (18,2% 6,6 66 29,7. 297 29,7 29 29,7) 17,1% 171 17 1 (17,1% 7,6 76 26,6, 266 26,6 26 26,6) 13,4% 134 13 4 (13,4% 5,1 51 21,7 217 21 11,4% 114 (11,4% 4,6 46 18,1. 181 18,1 18,1) Observouse Observou se 8,9% 89 (8,9% 3,8 38 3 141 14,1 8,8% 88 2,0 20 0 156 15 15,6 homens. homens) 2019202 201 202 (2019-202 (ELSI-Brasil 8,6 (8,6 IC9 6, 10, 11,9 (11,9 9, 14, 23,5 (23,5 7, 39, 18,2 (18,2 29, 17,1 (17,1 26, 13,4 (13,4 5, 21, 11,4 (11,4 4, 18, 8,9 (8,9 3, 8,8 2, 15, 201920 (2019-20 8, (8, 11, (11, 23, (23, (18, 17, (17, 13, (13, 20192 (2019-2 (8 (11 (23 (18 (17 (13 (2019- ( (1 (2 (2019 (201 (20

Based on a national representative sample of the population aged 50 years or older, this study aimed to estimate the prevalence of frailty among men and women, identify associated sociodemographic and health factors, and estimate the population attributable fraction. Data from the second wave (2019-2021) of the Brazilian Longitudinal Study of Aging (ELSI-Brazil) were used. Frailty was classified based on the number of positive items among unintentional weight loss, exhaustion, low level of physical activity, slow gait, and weakness. The main analyses were based on multinomial logistic regression stratified by sex. The prevalence of frailty was lower in men (8.6%; 95%CI: 6.9; 10.7) than in women (11.9%; 95%CI: 9.6; 14.8), with the most frequent item being the low level of physical activity in both. Age and schooling level were the sociodemographic factors associated with pre-frailty and fragility among men and women. The population attributable fraction was different for frailty between genders. In men, the highest population attributable fraction was due to not having a partner (23.5%; 95%CI: 7.7; 39.2) and low schooling level (18.2%; 95%CI: 6.6; 29,7). In women, higher population attributable fraction values were due to memory deficit (17.1%; 95%CI: 7.6; 26.6), vision deficit (13.4%; 95%CI: 5.1; 21.7), and diabetes mellitus (11.4%; 95%CI: 4.6; 18,1). Similar population attributable fraction levels were observed for heart disease (8.9%; 95%CI: 3.8; 14.1 in women and 8.8%; 95%CI: 2.0; 15.6 in men). Strategies aimed at physical activity have the potential to prevent frailty in both men and women, and the prevention of chronic conditions is more important in women. 5 older 20192021 2019 2021 (2019-2021 ELSIBrazil ELSI Brazil (ELSI-Brazil used loss exhaustion gait weakness sex 8.6% 86 8 6 (8.6% 95%CI 95CI CI 95 6.9 69 9 10.7 107 10 7 11.9% 119 11 (11.9% 9.6 96 14.8, 148 14.8 , 14 14.8) prefrailty pre genders 23.5% 235 23 (23.5% 7.7 77 39.2 392 39 2 18.2% 182 18 (18.2% 6.6 66 29,7. 297 29,7 . 29 29,7) 17.1% 171 17 1 (17.1% 7.6 76 26.6, 266 26.6 26 26.6) 13.4% 134 13 4 (13.4% 5.1 51 21.7, 217 21.7 21 21.7) 11.4% 114 (11.4% 4.6 46 18,1. 181 18,1 18,1) 8.9% 89 (8.9% 3.8 38 3 141 14. 8.8% 88 2.0 20 0 156 15 15. men. men) 2019202 201 202 (2019-202 8.6 (8.6 6. 10. 11.9 (11.9 9. 23.5 (23.5 7. 39. 18.2 (18.2 29, 17.1 (17.1 26. 13.4 (13.4 5. 21. 11.4 (11.4 4. 18, 8.9 (8.9 3. 8.8 2. 201920 (2019-20 8. (8. 11. (11. 23. (23. 18. (18. 17. (17. 13. (13. 20192 (2019-2 (8 (11 (23 (18 (17 (13 (2019- ( (1 (2 (2019 (201 (20

Este estudio tuvo por objetivo estimar, utilizando una muestra nacional representativa de la población de 50 años o más, la prevalencia de la fragilidad entre hombres y mujeres, identificar los factores sociodemográficos y de salud asociados, y calcular la fracción atribuible a la población. Se utilizaron datos de la 2ª ola (2019-2021) del Estudio Longitudinal de Salud de los Ancianos Brasileños (ELSI-Brasil). La fragilidad se clasificó por el número de elementos positivos entre pérdida de peso no intencional, agotamiento, bajo nivel de actividad física, marcha lenta y debilidad. Los principales análisis se basaron en la regresión logística multinomial estratificada por sexo. La prevalencia de fragilidad fue menor en los hombres (8,6%; IC95%: 6,9; 10,7) que en las mujeres (11,9%; IC95%: 9,6; 14,8), y como ítem más frecuente el bajo nivel de actividad física en ambos. La edad y el nivel educativo fueron los factores sociodemográficos asociados a la pre-fragilidad y la fragilidad entre hombres y mujeres. Hubo una diferencia en fracción atribuible a la población para la fragilidad entre los sexos. Entre los hombres, la fracción atribuible a la población más elevada fue no tener pareja (23,5%; IC95%: 7,7; 39,2) y bajo nivel educativo (18,2%; IC95%: 6,6; 29,7). Entre las mujeres, las fracción atribuible a la población más elevadas fueron déficit de memoria (17,1%; IC95%: 7,6; 26,6), déficit de visión (13,4%; IC95%: 5,1; 21,7) y diabetes mellitus (11,4%; IC95%: 4,6; 18,1). Se observaron fracción atribuible a la población similares para enfermedades cardíacas (8,9%; IC95%: 3,8; 14,1 en mujeres, y 8,8%; IC95%: 2,0; 15,6 en hombres). Las estrategias dirigidas a la actividad física tienen el potencial de prevenir la fragilidad en ambos sexos, mientras que la prevención de enfermedades crónicas es más necesaria en las mujeres. estimar 5 ª 20192021 2019 2021 (2019-2021 ELSIBrasil. ELSIBrasil ELSI Brasil . (ELSI-Brasil) intencional agotamiento debilidad sexo 8,6% 86 8 6 (8,6% IC95% IC95 IC 6,9 69 9 10,7 107 10 7 11,9% 119 11 (11,9% 9,6 96 14,8, 148 14,8 , 14 14,8) prefragilidad pre sexos 23,5% 235 23 (23,5% 7,7 77 39,2 392 39 2 18,2% 182 18 (18,2% 6,6 66 29,7. 297 29,7 29 29,7) 17,1% 171 17 1 (17,1% 7,6 76 26,6, 266 26,6 26 26,6) 13,4% 134 13 4 (13,4% 5,1 51 21,7 217 21 11,4% 114 (11,4% 4,6 46 18,1. 181 18,1 18,1) 8,9% 89 (8,9% 3,8 38 3 141 14, 8,8% 88 2,0 20 0 156 15 15, hombres. hombres) 2019202 201 202 (2019-202 (ELSI-Brasil 8,6 (8,6 IC9 6, 10, 11,9 (11,9 9, 23,5 (23,5 7, 39, 18,2 (18,2 29, 17,1 (17,1 26, 13,4 (13,4 5, 21, 11,4 (11,4 4, 18, 8,9 (8,9 3, 8,8 2, 201920 (2019-20 8, (8, 11, (11, 23, (23, (18, 17, (17, 13, (13, 20192 (2019-2 (8 (11 (23 (18 (17 (13 (2019- ( (1 (2 (2019 (201 (20

https://doi.org/10.1590/0102-311xpt144923

Use of platelet-rich plasma on in vitro maturation during bovine embryo production plateletrich platelet rich
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Souza, Eduardo Baia de

; Marin, Diego Dubeibe

; Ramos, Anelise Sarges

; Homobono, Bruno Porpino

; Ramos, Priscilla do Carmo de Azevedo

; Brito, Vanessa Cunha de

; Cruz, Gabriela Santos da

; Costa, Nathalia Nogueira da

; Cordeiro, Marcela da Silva

; Santos, Simone do Socorro Damasceno

Animal Reproduction

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2024, Volume 21 N. 1 elocation e20230107

Abstract: En | Text: En | PDF: En

Abstract One of the crucial aspects to be considered for successful in vitro production (IVP) of embryos is the composition of the various media used throughout the stages of this reproductive biotechnology. The cell culture media employed should fulfill the metabolic requirements of both gametes during oocyte maturation and sperm development, as well as the embryo during its initial cell divisions. Most IVP protocols incorporate blood serum into the media composition as a source of hormones, proteins, growth factors, and nutrients. Numerous studies have suggested Platelet-Rich Plasma (PRP) as a substitute for fetal sera in cell culture, particularly for stem cells. Therefore, the objective of this study is to assess the potential use of PRP as a replacement for fetal bovine serum (FBS) during oocyte maturation for in vitro production of bovine embryos. During in vitro maturation (IVM), cumulus-oocyte complexes (COCs) were allocated into the following experimental groups: Group G1 (IVM medium with 5% PRP); Group G2 (MIV medium with 5% PRP and 5% SFB); Group G3 (MIV medium with 5% SFB); and Group G4 (MIV medium without either PRP or SFB). Subsequently, the cumulus-oocyte complexes were fertilized with semen from a single bull, and the resulting zygotes were cultured for seven days. Cleavage and blastocyst formation rates were assessed on days 2 and 7 of embryonic development, respectively. The quality of matured COCs was also evaluated by analyzing the gene expression of HSP70, an important protein associated with cellular stress. The results demonstrated that there were no significant differences among the experimental groups in terms of embryo production rates, both in the initial cleavage stages and blastocyst formation (except for the G4 group, which exhibited a lower blastocyst formation rate on D7, as expected). This indicates that PRP could be a cost-effective alternative to SFB in the IVP of embryos. (IVP biotechnology development divisions hormones proteins factors nutrients PlateletRich Platelet Rich (PRP cells Therefore FBS (FBS IVM, IVM , (IVM) cumulusoocyte cumulus (COCs G 5 PRP) MIV SFB) SFB. . Subsequently bull respectively HSP70 HSP stress except group D7 D expected. expected expected) costeffective cost effective HSP7

https://doi.org/10.1590/1984-3143-ar2023-0107

Nanoemulsion with wine lees: a green approach lees
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SOUZA, ANA LUCIA A.S. DE

; GOMES, ANNE KATHERINE C.

; MORGADO, CARINA S.

; R. JUNIOR, EDUARDO

; SIMAS, NAOMI K.

; SANTOS, ELISABETE P. DOS

; AZEVEDO, ALINE D.

; GOMES, ANNE CAROLINE C.

; MONTEIRO, MARIANA S.S.B.

Anais da Academia Brasileira de Ciências

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2024, Volume 96 N. 2 elocation e20230373

Abstract: En | Text: En | PDF: En

Abstract Bioactive substances can be found in wine lees, a waste from the winemaking industry. This work developed two formulations, a nanoemulsion with coconut oil (NE-OC) and a nanoemulsion with coconut oil and 0.5% of wine lees extract (NE-OC-Ext), to investigate their effect on untreated, bleached, and bleached-colored hair. The oil-in-water (O/W) nanoemulsions were prepared with coconut oil, TweenTM 80, SpanTM 80, AristoflexTM AVC, Conserve NovaMit MFTM, wine lees extract, and deionized water. The hydration measurements were carried out using a Corneometer® CM 825 with the capacitance method. Scanning electron microscopy (SEM) was used to characterize the effect of formulations on hair fibers. Differential Thermal Analysis (DTA) was to assess the thermal stability and compatibility of wine lees and coconut oil in formulations. Compared to NE-OC, NE-OC-Ext showed a greater hydration effect on bleached-colored hair. DTA showed that NE-OC-Ext presented a smaller number of exothermic degradation events than those of NE-OC, suggesting good interaction and compatibility of the wine lees extract in this formulation. This study highlights the value of wine lees, a residue from the winemaking process, and its possibility of use as raw material for the cosmetic hair industry since it shows a greater moisturizing potential in colored hair. NEOC NE OC (NE-OC 05 0 5 0.5 NEOCExt, NEOCExt Ext , (NE-OC-Ext) untreated bleached bleachedcolored oilinwater water O/W OW O W (O/W 80 AVC MFTM Corneometer 82 method SEM (SEM fibers (DTA NEOC, OC, NE-OC formulation process 0. (NE-OC-Ext 8

https://doi.org/10.1590/0001-3765202420230373

III BRAZILIAN CONSENSUS STATEMENT ON ENDOSCOPIC ULTRASOUND
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PESSOA, Ricardo Rangel de Paula

; BESTETTI, Alexandre Moraes

; OLIVEIRA, Victor Lira de

; ARAUJO, Wladimir Campos de

; GUARALDI, Simone

; RODRIGUES SILVA, Rodrigo Roda

; OLIVEIRA, Francisco Antonio Araujo

; RIBEIRO, Maria Sylvia Ierardi

; CARNEIRO, Fred Olavo Aragão Andrade

; D’ASSUNÇÃO, Marco Aurélio

; MEDRADO, Bruno Frederico Oliveira Azevedo

; RETES, Felipe Alves

; PAULO, Gustavo Andrade de

; SCHNEIDER, Nutianne Camargo

; ROSSINI, Lucio Giovanni Battista

; VALLINOTO, Leonardo

; ARDENGH, Jose Celso

; COELHO NETO, Djalma Ernesto

; IDE, Edson

; SILVA, Marcos Clarencio Batista

; FRANCO, Matheus Cavalcante

; MATUGUMA, Sergio Eiji

; MOURA, Diogo Turiani Hourneaux de

; ARANTES, Vitor Nunes

; NAHOUM, Rafael

; BRUNALDI, Vitor Ottoboni

; SANTOS, Marcos Eduardo Lera dos

; CHAVES, Dalton Marques

; MICELLI-NETO, Otávio

; SALOMAO, Bruno Chaves

; MALUF-FILHO, Fauze

; LUZ, Gustavo de Oliveira

Arquivos de Gastroenterologia

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2024, Volume 61 elocation e24062

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Contexto: Nas últimas décadas, a ecoendoscopia evoluiu de uma ferramenta diagnóstica para uma plataforma para diversas intervenções terapêuticas. Vários avanços tecnológicos surgiram desde o último Consenso Brasileiro, demandando uma revisão e atualização das recomendações baseadas nas melhores evidências científicas. Métodos: Um grupo de 32 ecoendoscopistas renomados selecionou oito tópicos relevantes para serem discutidos a fim de gerar questões clínicas. Em seguida, foi realizada uma revisão da literatura para responder a essas perguntas com base nas evidências mais atualizadas. Resultados: Trinta e três tópicos foram formulados e votados pelos especialistas para alcançar um consenso. O Sistema de Oxford foi utilizado para classificar o nível de evidência. Conclusão: Há evidências moderadas para sustentar que a forma da agulha, calibre ou técnica de aspiração não influenciam no rendimento da amostragem tecidual guiada por ultrassom endoscópico (USE) de lesões sólidas pancreáticas. Há evidências moderadas para sustentar o uso da biópsia transcutânea guiada por USE da parede cística para diferenciar entre neoplasias císticas mucinosas e não mucinosas. Existem poucas evidências para apoiar o tratamento guiado por USE de varizes gástricas. Há um alto nível de evidência para sustentar que a drenagem biliar guiada por USE e a CPRE apresentam resultados semelhantes em pacientes com obstrução biliar maligna distal. Há um alto nível de evidência para o uso da USE no diagnóstico de cistos pancreáticos neoplásicos e na detecção de necrose antes de indicar a drenagem. Há evidências moderadas para sustentar a preferência pela gastroenterostomia guiada por USE em relação ao stent duodenal para obstrução maligna da saída gástrica em pacientes com expectativa de vida superior a 2 meses. Há um alto nível de evidência para sustentar o uso da ablação por radiofrequência no tratamento de ambos os tipos, funcionantes e não funcionantes, de tumores neuroendócrinos. Contexto décadas terapêuticas Brasileiro científicas Métodos 3 clínicas seguida atualizadas Resultados consenso Conclusão agulha (USE pancreáticas gástricas distal meses tipos neuroendócrinos

ABSTRACT Background: In the past decades, endoscopic ultrasound has developed from a diagnostic tool to a platform for many therapeutic interventions. Various technological advancements have emerged since the last Brazilian Consensus, demanding a review and update of the recommendations based on the best scientific evidence. Methods: A group of 32 renowned echoendoscopists selected eight relevant topics to be discussed to generate clinical questions. After that, a literature review was conducted to answer these questions based on the most updated evidence. Results: Thirty-three statements were formulated and voted on by the experts to reach a consensus. The Oxford System was used to grade the level of evidence. Conclusion: There is moderate evidence to support that the needle shape, gauge, or aspiration technique does not influence the yield of endoscopic ultrasound (EUS)-guided tissue sampling of pancreatic solid lesions. There is moderate evidence to support using EUS-TTNB of the cyst wall to differentiate between mucinous and non-mucinous cystic neoplasms. There is little evidence to support the EUS-guided treatment of gastric varices. There is a high level of evidence to support that EUS-guided biliary drainage and ERCP present similar outcomes in patients with distal malignant biliary obstruction. There is a high level of evidence for using EUS to diagnose neoplastic pancreatic cysts and detect necrosis before indicating drainage. There is moderate evidence to support EUS-GE over duodenal stent for malignant gastric outlet obstruction in patients with a life expectancy higher than 2 months. There is a high level of evidence to support the use of RFA in treating both functioning and non-functioning types of NET. Background decades interventions Consensus Methods 3 Results Thirtythree Thirty three consensus Conclusion shape gauge EUSguided guided lesions EUSTTNB TTNB nonmucinous non neoplasms varices EUSGE GE months nonfunctioning NET

https://doi.org/10.1590/s0004-2803.24612024-062

Inclusion of covariables in genome-wide selection models for prediction accuracy genomewide genome wide
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Peixoto, Leonardo de Azevedo

; Teodoro, Paulo Eduardo

; Teodoro, Larissa Pereira Ribeiro

; Cruz, Cosme Damião

; Bhering, Leonardo Lopes

Pesquisa Agropecuária Brasileira

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2024, Volume 59 elocation e03534

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste trabalho foi avaliar modelos que utilizam os nucleotídeos de polimorfismo único significativos (SNPs), encontrados por seleção assistida por marcadores e associação genômica, como um efeito fixo em modelos comumente utilizados na seleção genômica ampla para a população F2, em comparação com o modelo que utiliza todos os SNPs. Utilizou-se para todos modelos o método bayesiano de regressão de crista. Para as comparações entre os modelos, avaliaram-se a capacidade de predição fenotípica e genotípica, a acurácia fenotípica, o ganho de seleção, o índice de coincidência e o tempo de processamento. Ambos os métodos não conseguiram identificar com precisão os verdadeiros loci de características quantitativas (QTL). A seleção baseada apenas nos QTL identificados pelos métodos avaliados elegeu indivíduos de baixo valor genético. O uso de um modelo de seleção genômica ampla -com os SNPs significativos encontrados pela associação genômica como um efeito fixo, e os SNPs restantes como um efeito aleatório – foi a estratégia adequada para selecionar indivíduos superiores com alta precisão. A introdução de QTL já descritos para uma dada característica no modelo de seleção genômica ampla permite a seleção de indivíduos superiores com maior precisão. SNPs, , (SNPs) F2 F Utilizouse Utilizou se crista avaliaramse avaliaram genotípica processamento QTL. . (QTL) genético (SNPs (QTL

Abstract The objective of this work was to evaluate models using the significant single nucleotide polymorphisms (SNPs) detected by marker-assisted selection and genome-wide association, as a fixed effect in the models commonly used in genome-wide selection for F2 population, in comparison with models using all SNPs. For all models, the Bayesian ridge regression method was used. Comparisons between the models were carried out to evaluate the phenotypic and genotypic prediction ability, phenotypic accuracy, selection gain, coincidence index, and processing time. Both methods failed to accurately identify true quantitative trait loci (QTL). The selection based only in the QTL identified by the studied methods elected individuals of low genetic value. The use of a genome-wide selection model – with the significant SNPs found by the genome-wide association as a fixed effect, and the remaining SNPs as a random effect – was the suitable strategy to select superior individuals with high accuracy. The introduction of QTL already described for a given trait into the genome-wide selection model allows of the selection of superior individuals with greater precision. (SNPs markerassisted marker assisted genomewide genome wide F population ability accuracy gain index time QTL. . (QTL) value precision (QTL

https://doi.org/10.1590/s1678-3921.pab2024.v59.03534

Minimum number of measurements for an accurate evaluation of growth traits in eucalyptus species
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Garcia, Janielle de Oliveira

; Borges, Marcus Vinicius Vieira

; Teodoro, Larissa Pereira Ribeiro

; Azevedo, Gileno Brito de

; Azevedo, Glauce Taís de Oliveira Sousa

; Teodoro, Paulo Eduardo

Revista Ceres

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2024, Volume 71 elocation e71055

Abstract: En | Text: En | PDF: En

ABSTRACT The objective of this research was to identify the most effective method to estimate the repeatability coefficients in species of eucalyptus and to predict the minimum number of measurements necessary for growth traits. The experimental design was randomized blocks, with five species, with four repetitions. Data were collected from five measurements during the period from 2014 to 2016, evaluated according to the diameter, chest height and total height. The repeatability coefficient (r) was estimated using different strategies: analysis of variance (ANOVA), principal component analysis based on the correlation matrix (PCCOR), principal components based on the phenotypic variance and covariance matrix (PCCOV), and structural analysis based on the correlation matrix (SACOR). The PCCOR and PCCOV provide accurate estimates of the repeatability coefficient and the number of measurements required. At least five measurements are necessary to predict the real value, with a minimum accuracy of 80%. traits blocks repetitions 201 2016 diameter r (r strategies ANOVA, ANOVA , (ANOVA) PCCOR, (PCCOR) PCCOV, (PCCOV) SACOR. SACOR . (SACOR) required value 80 80% 20 (ANOVA (PCCOR (PCCOV (SACOR 8 2

https://doi.org/10.1590/0034-737x2024710055

10.

Genetic parameters and correlations associated with the selection of kale clones via REML/BLUP estimates REMLBLUP REML BLUP
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Silva, Eduardo Alves da

; Costa, Ariana Lemes da

; Brito, Orlando Gonçalves

; Andrade Junior, Valter Carvalho de

; Gama, André Boscolo Nogueira da

; Azevedo, Sebastião Márcio de

Pesquisa Agropecuária Brasileira

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2024, Volume 59 elocation e03456

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste trabalho foi estimar os parâmetros genéticos e as correlações das características relacionadas à produção e à coloração de couve-de-folhas para selecionar os melhores genótipos a partir de estimativas REML/BLUP. O experimento foi realizado em delineamento de blocos inteiramente casualizados, com três repetições. Os tratamentos foram compostos por 34 clones experimentais de couve-de-folhas. Os parâmetros avaliados foram: produtividade total de folhas (PTF), número de folhas comerciais (NFC), massa média de folhas (MMF), número de brotações (NB), teor de clorofila (TC) e padrões colorimétricos de luminosidade (L), croma (C) e ângulo hue (h) das folhas. Estimaram-se os parâmetros genéticos, as correlações genotípicas e fenotípicas, e os valores genéticos. Os genótipos de couve-de-folhas UFLA 06, UFLA 14, UFLA 16, UFLA 22 e UFLA 34 têm boas características produtivas e intensa coloração verde, com alta herdabilidade. As características PTF, NFC, MMF, NB, TC e os parâmetros colorimétricos L e C apresentam herdabilidade alta em couve-de-folhas. PTF mostra uma correlação positiva com NFC e MMF em couve-de-folhas. Os genótipos UFLA 02, UFLA 04, UFLA 13, UFLA 25, UFLA 31 e UFLA 32 se destacam por suas características produtivas, mas não em níveis elevados de antioxidantes. O NFC apresenta uma correlação positiva com o NB, o que não beneficia a produção de sementes. couvedefolhas couve REMLBLUP REML BLUP REML/BLUP casualizados repetições 3 couvedefolhas. , (PTF) (NFC) (MMF) NB (NB) (TC L, (L) (C h (h Estimaramse Estimaram fenotípicas 06 14 16 2 verde 02 04 13 25 antioxidantes sementes (PTF (NFC (MMF (NB (L 0 1

Abstract The objective of this work was to estimate the genetic parameters and correlations of characteristics related to production and color in kale and to select the best genotypes based on REML/BLUP estimates. The experiment was carried out in a completely randomized block design, with three replicates. The treatments consisted of 34 experimental kale clones. The parameters evaluated were: total leaf yield (TLY), number of commercial leaves (NCL), average leaf mass (ALM), number of shoots (NS), chlorophyll content (CC), and colorimetric patterns of luminosity (L), chroma (C), and hue (h) of the leaves. Genetic parameters, genotypic and phenotypic correlations, and genetic values were estimated. The kale genotypes UFLA 06, UFLA 14, UFLA 16, UFLA 22, and UFLA 34 have good productive characteristics and intense green color, with high heritability. The characteristics TLY, NCL, ALM, NS, CC, and colorimetric patterns of L and C present high heritability in kale. TLY shows a positive correlation with the NCL and the ALM in kale. The genotypes UFLA 02, UFLA 04, UFLA 13, UFLA 25, UFLA 31, and UFLA 32 stand out for their productive characteristics, but not in high levels of antioxidants. The NCL presents positive correlation with the NS, which does not benefit seed production. REMLBLUP REML BLUP estimates design replicates 3 clones , (TLY) (NCL) (ALM) NS (NS) CC (CC) L, (L) C, (C) h (h estimated 06 14 16 22 02 04 13 25 31 antioxidants (TLY (NCL (ALM (NS (CC (L (C 0 1 2

https://doi.org/10.1590/s1678-3921.pab2024.v59.03456

11.

Herpetofauna of Nísia Floresta National Forest, Rio Grande do Norte, Brazil: Richness and abundance differences among natural and secondary forests Forest Norte Brazil
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Sousa, Maria Beatriz de Andrade

; Lion, Marília Bruzzi

; Costa, Winícius Mateus Magalhães

; Egl, Bryan André de Lima

; Figueiredo, Fabiany Herica

; Leite, Nicolas Vinicius A. A.

; Marcos, Daniel Victor Morais

; Magalhães, Felipe de Medeiros

; Matias, Cícera Silvilene Leite

; Neta, Aldenir Ferreira da Silva

; Oliveira, José Eduardo Gomes de

; Puertas, Igor Peres

; Queiroz, Vitória Godeiro de

; Silva, Daniel da Costa

; Silva, Willianilson Pessoa da

; Silveira Filho, Ricardo Rodrigues da

; Soares, Matheus Lucas Azevedo

; Mesquita, Daniel Oliveira

; Garda, Adrian Antonio

Biota Neotropica

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2024, Volume 24 N. 3 elocation e20241643

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Na Mata Atlântica, as distribuições de espécies não são uniformes. O bioma foi dividido em 8 sub-regiões biogeográficas, como o Centro de Endemismo de Pernambuco (CEP), no nordeste do Brasil. A Floresta Nacional de Nísia Floresta (Flona) é uma área protegida situada no município de Nísia Floresta, no Estado do Rio Grande do Norte, abrigando vegetação nativa (Mata Atlântica e "Restingas ou Tabuleiros"), bem como áreas em regeneração, com parcelas experimentais de plantas exóticas para produção de madeira. Aqui, apresentamos, pela primeira vez, uma lista de espécies da herpetofauna levantada na Flona ao longo dos últimos 10 anos, utilizando uma amostragem padronizada e de longo prazo, juntamente encontros visuais e ocasionais. Realizamos levantamentos mensais em toda a área utilizando 84 armadilhas de queda distribuídas aleatoriamente em 21 conjuntos ao longo das três zonas fitogeográficas da floresta (Restinga, Mata Atlântica e Regeneração). Além disso, caracterizamos a diversidade da herpetofauna terrestre nessas três zonas ao longo de um ano inteiro. Coletamos um total de 39 espécies de répteis (entre lagartos, serpentes, quelônios, crocodilianos e anfisbênios) e 24 espécies de anfíbios. A família mais frequente encontrada para os répteis foi Dipsadidae, seguida por Colubridae. Para anfíbios, Leptodactylidae foi a mais comum, seguida por Hylidae. A diversidade da herpetofauna em áreas de regeneração é menor do que em florestas, que por sua vez são marginalmente menos diversas do que a Restinga. Descritores da comunidade, como equidade, presença de espécies exclusivas e diferenças em abundâncias e composição indicam que estratégias de manejo distintas para cada área são necessárias para esta área protegida. Por fim, embora menor, a diversidade em áreas de regeneração é semelhante às áreas naturais, um resultado animador considerando o significativo desmatamento que a Mata Atlântica sofreu e a urgente necessidade de iniciativas de restauração. uniformes subregiões sub regiões biogeográficas CEP, CEP , (CEP) Brasil (Flona Norte Restingas Tabuleiros, Tabuleiros Tabuleiros") madeira Aqui apresentamos 1 anos prazo ocasionais 2 Restinga, Restinga (Restinga Regeneração. Regeneração . Regeneração) disso inteiro 3 entre lagartos serpentes quelônios anfisbênios anfíbios Dipsadidae Colubridae comum Hylidae florestas comunidade equidade fim naturais restauração (CEP Tabuleiros"

Abstract In the Atlantic Forest, species distributions are not uniform. The biome has been divided into 8 biogeographic sub-regions, such as the Pernambuco Center of Endemism (PCE), in northeastern Brazil. Nísia Floresta National Forest (Flona) is a protected area situated in the municipality of Nísia Floresta, Rio Grande do Norte state, harboring native vegetation (Atlantic Forest and "Restingas or Tabuleiros") as well regenerating areas, with experimental plots of exotic plants for timber production. Herein, we present, for the first time, a species list of the herpetofauna surveyed at Flona over the past 10 years, using a standardized, long-term sampling design along with visual encounter surveys. We conducted monthly surveys across the area using 84 pitfall traps randomly distributed in 21 arrays throughout the forest's three phytogeographic zones (Restinga, Atlantic Forest, and Regeneration). In addition, we characterized ground-dwelling herpetofauna community diversity across these three zones over the course of an entire year. We collected a total of 39 species of reptiles (among lizards, snakes, chelonians, alligators, and amphisbaenians) and 24 species of frogs. The most frequent family found for reptiles was Dipsadidae, followed by Colubridae. In frogs, Leptodactylidae was the most common, followed by Hylidae. Herpetofaunal diversity in regeneration areas is smaller than forests, which in turn are marginally less diverse than the Restinga. Community descriptors such as equity, presence of exclusive species, and differences in abundances and composition indicate that distinct management strategies for each zone are needed for this protected area. At last, albeit smaller, diversity in regenerating areas is similar to natural areas, a reassuring result considering the significant deforestation the Atlantic Forest has suffered and the urgent need for restoration initiatives. uniform subregions, subregions sub regions, regions sub-regions PCE, PCE , (PCE) Brazil (Flona state Restingas Tabuleiros Tabuleiros" production Herein present time 1 years standardized longterm long term 2 forests forest s Restinga, Restinga (Restinga Regeneration. Regeneration . Regeneration) addition grounddwelling ground dwelling year 3 among lizards snakes chelonians alligators amphisbaenians frogs Dipsadidae Colubridae common Hylidae equity last initiatives (PCE

https://doi.org/10.1590/1676-0611-bn-2024-1643

12.

Utilização da toxina botulínica para o tratamento de cicatriz queloide: revisão de escopo queloide
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MONTEIRO, EDUARDO LAFAYETTE

; QUEIROZ, KARINE LORENA SOUSA

; AZEVEDO, THIAGO ALEXANDRE MACEDO DE

Revista Brasileira de Cirurgia Plástica

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2024, Volume 39 N. 1 elocation e0841

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: Cicatrizes visíveis podem acarretar agravos, sejam estéticos, psicológicos, funcionais ou sociais, principalmente de grande extensão e volume, como os queloides. A descoberta de novos tratamentos de queloides não é fácil, visto a presença de alguns entraves metodológicos e éticos, sendo uma área pouco explorada. A toxina botulínica tem sido apresentada como alternativa terapêutica em estudos nacionais e internacionais, sendo necessária uma compilação e destaque dos principais estudos que possam subsidiar a prática clínica. Assim, o objetivo foi apresentar uma revisão de escopo sobre a utilização terapêutica da toxina botulínica para o tratamento de cicatrizes queloides. Método: A revisão foi realizada através da estratégia PICO e utilizando o Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews. Foi realizada nas bases de dados PubMed/ Medline, Biblioteca Virtual em Saúde e SciELO, considerando estudos do período de 2016 até setembro de 2021. Resultados: Foram encontrados 34 artigos no geral relacionados ao tema. Após filtragem e seleção, a revisão foi construída com apoio de 5 artigos. Os estudos variaram entre coorte, relatos de caso, ensaio clínico randomizado e caso-controle. Foi possível observar como principais resultados a ação a curto prazo da toxina botulínica na redução de queloides, maior efetividade na redução dos sintomas e possibilidades de utilização clínica para diferentes populações e manifestações clínicas. Conclusão: O mecanismo de ação da toxina botulínica pode facilitar o tratamento de queloides e redução de sintomas, sendo necessários estudos mais robustos para definição de protocolos cínicos de gestão de cicatrizes. Introdução agravos estéticos psicológicos sociais volume fácil éticos explorada internacionais Assim Método MetaAnalyses Meta Analyses Reviews PubMed Medline SciELO 201 2021 Resultados 3 tema seleção coorte caso casocontrole. casocontrole controle. controle caso-controle clínicas Conclusão 20 202 2

ABSTRACT Introduction: Visible scars can cause problems, whether aesthetic, psychological, functional, or social, mainly of great extension and volume, such as keloids. The discovery of new treatments for keloids is not easy, given the presence of some methodological and ethical obstacles, and it is an area that is little explored. Botulinum toxin has been presented as a therapeutic alternative in national and international studies, requiring a compilation and highlighting of the main studies that can support clinical practice. Thus, the objective was to present a scoping review on the therapeutic use of botulinum toxin for the treatment of keloid scars. Method: The review was carried out using the PICO strategy and using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. It was carried out in the PubMed/Medline, Virtual Health Library, and SciELO databases, considering studies from 2016 to September 2021. Results: Overall, 34 articles related to the topic were found. After filtering and selection, the review was constructed with the support of 5 articles. The studies varied between cohorts, case reports, randomized clinical trials, and case-control. It was possible to observe as main results of the short-term action of botulinum toxin in reducing keloids, greater effectiveness in reducing symptoms, and possibilities of clinical use for different populations and clinical manifestations. Conclusion: The mechanism of action of botulinum toxin can facilitate the treatment of keloids and reduce symptoms, requiring more robust studies to define effective scar management protocols. Introduction problems aesthetic psychological functional social volume easy obstacles explored practice Thus Method MetaAnalyses Meta Analyses PubMedMedline PubMed Medline PubMed/Medline Library databases 201 2021 Results Overall 3 found selection cohorts reports trials casecontrol. casecontrol control. control case-control shortterm short term symptoms manifestations Conclusion protocols 20 202 2

https://doi.org/10.5935/2177-1235.2024rbcp0841-pt

13.

Cross-cultural adaptation of the Scale of Perception of Respect for and Maintenance of the Dignity of the Inpatient (CuPDPH) to Brazilian Portuguese and its psychometric properties—A multicenter cross-sectional study Crosscultural Cross cultural CuPDPH (CuPDPH propertiesA properties A crosssectional cross sectional
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Dutra, Pablo Eduardo Pereira

; Quagliato, Laiana Azevedo

; Curupaná, Filipe Terra

; Peres, Letícia Zangirolami

; Pacini, Victoria Luiza

; Silva, Claudia Regina Menezes da

; Garcia, Juliana Seixas

; Zaragoza, Beatriz Campillo

; Nardi, Antonio Egidio

Clinics

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2024, Volume 79 elocation 100328

Abstract: En | Text: En | PDF: En

Abstract Objective To adapt the Scale of Perception of Respect for and Maintenance of the Dignity of the Inpatient (CuPDPH) to the Brazilian language and culture and to assess its psychometric properties. Results The scale was evaluated by 15 experts, and 239 patients from three tertiary hospitals in Rio de Janeiro. All participants signed a consent form. Data have shown adequacy of the model (KMO=0.839, Bartlett's test of sphericity: χ2(171) = 2241.3, p = 0.000010), good adjusted content validity (CVCa ≥ 0.90), internal consistency and reliability, such as α = 0.927. Discussion CuPDPH is a rating scale on observable professional attitudes. Illnesses change lives and impose adaptation to a new situation, perceived as depersonalization, leading patients to try to regain control of their lives. Patients expressed “ill will” to fill out the scale. Psychiatric patients’ scale filling time was higher than others. A sample from three Rio de Janeiro third-level hospitals may not reflect the country's population; also, this adaptation may not comprise all linguistic variations of Brazilian Portuguese and Portuguese-speaking countries. Conclusion The Portuguese version of the Scale of Perception of Respect for and Maintenance of the Dignity of the Inpatient (CuPDPH), a 19-item, six-component version is a reliable instrument to measure the perception of internal medicine, surgical, and psychiatric patients on the maintenance of their dignity in Rio de Janeiro, Brazil. This knowledge could be used in advancing research on patients’ perception of dignity, as well as professional ethical competencies, staff-patient relationship skills, and leadership development in medical and other healthcare professional education. (CuPDPH properties 1 experts 23 form KMO=0.839, KMO0839 KMO 0 839 (KMO=0.839 Bartletts Bartlett s sphericity χ2171 χ χ2 171 χ2(171 22413 2241 3 2241.3 0.000010, 0000010 0.000010 , 000010 0.000010) CVCa 0.90, 090 0.90 90 0.90) reliability 0927 927 0.927 attitudes situation depersonalization ill will others thirdlevel third level countrys country population also Portuguesespeaking speaking countries CuPDPH, 19item, 19item item 19 item, 19-item sixcomponent six component medicine surgical Brazil competencies staffpatient staff patient skills education 2 KMO=0.839 KMO083 83 (KMO=0.83 χ217 17 χ2(17 224 2241. 000001 0.00001 00001 09 0.9 9 092 92 0.92 KMO=0.83 KMO08 8 (KMO=0.8 χ21 χ2(1 22 00000 0.0000 0000 0. KMO=0.8 KMO0 (KMO=0. χ2( 0.000 000 KMO=0. (KMO=0 0.00 00 KMO=0 (KMO= 0.0 KMO= (KMO

https://doi.org/10.1016/j.clinsp.2024.100328

14.

RNA sequencing and gene co-expression network of in vitro matured oocytes and blastocysts of buffalo coexpression co expression
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Santana, Priscila Di Paula Bessa

; Pinheiro, Kenny da Costa

; Pereira, Lino César de Souza

; Andrade, Soraya Silva

; Aburjaile, Flávia Figueira

; Ramos, Priscilla do Carmo de Azevedo

; Souza, Eduardo Baia de

; Costa, Nathalia Nogueira da

; Cordeiro, Marcela da Silva

; Santos, Simone do Socorro Damasceno

; Miranda, Moysés dos Santos

; Ramos, Rommel Thiago Jucá

; Silva, Artur Luiz da Costa da

Animal Reproduction

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2024, Volume 21 N. 2 elocation e20230131

Abstract: En | Text: En | PDF: En

Abstract In reproductive technologies, uncovering the molecular aspects of oocyte and embryo competence under different conditions is crucial for refining protocols and enhancing efficiency. RNA-seq generates high-throughput data and provides transcriptomes that can undergo additional computational analyses. This study presented the transcriptomic profiles of in vitro matured oocytes and blastocysts produced in vitro from buffalo crossbred (Bubalus bubalis), coupled with gene co-expression and module preservation analysis. Cumulus Oophorus Complexes, obtained from slaughterhouse-derived ovaries, were subjected to in vitro maturation to yield metaphase II oocytes (616) or followed in vitro fertilization and culture to yield blastocysts for sequencing (526). Oocyte maturation (72%, ±3.34 sd) and embryo development (21.3%, ±4.18 sd) rates were obtained from three in vitro embryo production routines following standard protocols. Sequencing of 410 metaphase II oocytes and 70 hatched blastocysts (grade 1 and 2) identified a total of 13,976 genes, with 62% being ubiquitously expressed (8,649). Among them, the differentially expressed genes (4,153) and the strongly variable genes with the higher expression (fold-change above 11) were highlighted in oocytes (BMP15, UCHL1, WEE1, NLRPs, KPNA7, ZP2, and ZP4) and blastocysts (APOA1, KRT18, ANXA2, S100A14, SLC34A2, PRSS8 and ANXA2) as representative indicators of molecular quality. Additionally, genes exclusively found in oocytes (224) and blastocysts (2,200) with specific biological functions were identified. Gene co-expression network and module preservation analysis revealed strong preservation of functional modules related to exosome components, steroid metabolism, cell proliferation, and morphogenesis. However, cell cycle and amino acid transport modules exhibited weak preservation, which may reflect differences in embryo development kinetics and the activation of cell signaling pathways between buffalo and bovine. This comprehensive transcriptomic profile serves as a valuable resource for assessing the molecular quality of buffalo oocytes and embryos in future in vitro embryo production assays. technologies efficiency RNAseq RNA seq highthroughput high throughput analyses Bubalus bubalis, bubalis , bubalis) coexpression co Complexes slaughterhousederived slaughterhouse derived ovaries 616 (616 526. 526 . (526) 72%, 72 (72% 334 3 34 ±3.3 sd 21.3%, 213 21 (21.3% 418 4 18 ±4.1 41 7 grade 2 13976 13 976 13,97 62 8,649. 8649 8,649 8 649 (8,649) them 4,153 4153 153 (4,153 foldchange fold change 11 BMP15, BMP15 BMP (BMP15 UCHL1 UCHL WEE1 WEE NLRPs KPNA7 KPNA ZP2 ZP ZP4 APOA1, APOA1 APOA (APOA1 KRT18 KRT ANXA2 ANXA S100A14 SA S A SLC34A2 SLCA SLC PRSS Additionally 224 (224 2,200 2200 200 (2,200 components metabolism proliferation morphogenesis However bovine assays 61 (61 52 (526 72% (72 33 ±3. 21.3% (21.3 ±4. 1397 97 13,9 6 864 8,64 64 (8,649 4,15 415 15 (4,15 BMP1 (BMP1 (APOA KRT1 S100A1 SLC34A 22 (22 2,20 220 20 (2,20 (6 5 (52 (7 ±3 21.3 (21. ±4 139 9 13, 86 8,6 (8,64 4,1 (4,1 (BMP S100A (2 2,2 (2,2 ( (5 ± 21. (21 8, (8,6 4, (4, 2, (2, (8, (4 (8

https://doi.org/10.1590/1984-3143-ar2023-0131

15.

Pyrophosphate Scintigraphy: Use in the Diagnosis and Monitoring of Cardiac Amyloidosis Scintigraphy
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Mesquita, Claudio Tinoco

; Yahiro, Davi Shunji

; Santos, José Felipe Ramos dos

; Machado, Luís Eduardo

; Rodriguez, Jose Gregorio Valero

; Azevedo Junior, Giovane Leal de

; Simões, Marcus

International Journal of Cardiovascular Sciences

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2024, Volume 37 elocation e20240051

Abstract: En | Text: En | PDF: En

Abstract Cardiac amyloidosis (CA) is a progressive condition marked by the accumulation of amyloid fibrils in cardiac tissue, resulting in cardiac dysfunction and, ultimately, heart failure. Pyrophosphate scintigraphy has emerged as a promising tool for the early detection and monitoring of CA, providing valuable insights into the disease's extent and severity. This review examines the current use of pyrophosphate scintigraphy in distinguishing between different types of amyloidosis, assessing risk levels, and monitoring patients with CA. It underscores the clinical significance and prospects of this imaging technique. CA (CA tissue ultimately failure diseases disease s severity levels technique

https://doi.org/10.36660/ijcs.20240051

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