RESUMO O processo de envelhecimento populacional levará a um aumento de problemas de saúde nas pessoas idosas, principalmente relacionados à sua funcionalidade. Nesse sentido, os países da Região das Américas devem começar a agir para enfrentar esse desafio. Uma das tarefas fundamentais está relacionada à capacidade de medir e monitorar a funcionalidade da população. Os instrumentos utilizados para avaliá-la estão voltados principalmente para as atividades básicas da vida diária, o que limita sua capacidade preventiva, já que são as atividades instrumentais que permitem um melhor prognóstico. Utilizando o caso do Chile, identificamos desafios para a Região, principalmente relacionados às vantagens de incorporar novas metodologias de avaliação da capacidade funcional que não só habilitem as estratégias atuais, mas também detectem precocemente a deterioração da funcionalidade e monitorem suas fases ao longo da dependência das pessoas idosas. Isso permitirá, ao mesmo tempo, avaliar as iniciativas de prevenção e manejo da perda de funcionalidade.

ABSTRACT The process of population aging will lead to an increase in health problems in older people, mainly related to their functionality. Accordingly, the countries of the Region of the Americas must begin to act to meet this challenge. One of the fundamental tasks involves the ability to measure and monitor functionality in the population. The tools used to evaluate functionality focus mainly on the basic activities of daily living, which limits their preventive capacity, since instrumental activities provide a better prognosis. Using the case of Chile, challenges for the Region were identified, mainly related to the advantages of adopting new methodologies that not only evaluate functional capacity, as current strategies do, but also detect its deterioration early and monitor its stages throughout the dependence stage in older people. This will also make it possible to evaluate initiatives for the prevention and management of loss of functionality.

RESUMEN El proceso de envejecimiento poblacional llevará a un aumento en problemas de salud en personas mayores, principalmente relacionados a su funcionalidad. En esta línea, los países de la Región de las Américas deben comenzar a actuar para hacer frente a este desafío. Una de las tareas fundamentales en este reto tiene que ver con la capacidad de medir y monitorear la funcionalidad de la población. Los instrumentos utilizados para evaluarla están enfocados principalmente en las actividades básicas de la vida diaria, lo que limita su capacidad preventiva por ser las actividades instrumentales las que permiten un mejor pronóstico. Usando el caso de Chile identificamos desafíos para la Región, principalmente relacionados con las ventajas de incorporar nuevas metodologías de evaluación de la capacidad funcional que no solo permitan las estrategias actuales sino, también, detectar precozmente su deterioro y monitorear sus estadios a lo largo de la dependencia en las personas mayores. Ello permitirá, a la vez, evaluar las iniciativas de prevención y manejo de la pérdida de la funcionalidad.

Abstract Background: Psoriasis and periodontitis are immunologically mediated chronic inflammatory diseases. Epidemiologic evidence has linked both; however, the change of markers in gingival crevicular fluid has been poorly evaluated. Objective: To evaluate the levels of IL-17A, IL-22, IL-23, S100A7, S100A8, and S100A9 in gingival crevicular fluid of psoriatic and healthy subjects with and without periodontitis and their relations to psoriasis severity. Methods: Cross-sectional study. Sample comprised the following groups: healthy controls without periodontitis or with mild periodontitis (n = 21), healthy controls with moderate or severe periodontitis (n = 18), individuals with psoriasis without or mild periodontitis (n = 11), and individuals with psoriasis and moderate or severe periodontitis (n = 32). Levels of IL-17A, IL-22, IL-23, S100A8, and S100A9 were determined by multiplex assay and S100A7 was measured by ELISA. Results: No inter-group differences in the levels of IL-17A, IL-22, IL-23, and S100A7 were found. S100A8 levels were higher in psoriatic patients than controls (p < 0.05). S100A8 was positively correlated with psoriasis severity in the group with psoriasis (p < 0.05). S100A9 exceeded the detection limits. Study limitations: This pilot study presents a small sample size. Conclusions: The concentrations of S100A8 were highest in psoriatic patients regardless of periodontal health/status. S100A8 was associated with the severity of psoriasis. The concentrations of interleukins and S100A7 were similar in psoriatic patients with or without periodontitis vs. healthy controls.

The world progressive ageing, along with other factors, have led to pension systems, its reforms and gender inequalities to international discussion. In this context, the Chilean debate inserted around the Pension Fund Administrators. The aim of this article is to learn about the experiences and perceptions of retired women by the private pension system in Chile, AFP, regarding the amounts of their current pension. For this, 16 retired women were interviewed, using Qualitative Content Analysis for data processing. The results show three categories: perception of fraud and repentance in the transfer to the AFP; gender discrimination in the workplace that impact on retirement; and impoverishment and suffering in daily life. We conclude that the subjective experiences of women are marked by suffering, helplessness and pessimism, making it difficult to aspire to a society with gender equality, if the pension system is configured as discriminatory and little solidary.

El envejecimiento progresivo mundial, junto a otros factores, han llevado a los sistemas de pensiones, sus reformas y las desigualdades de género a la discusión internacional. En este contexto se inserta el debate chileno en torno a las Administradoras de Fondos de Pensiones. Este artículo tiene como propósito conocer las vivencias y percepciones de mujeres jubiladas por el sistema de pensiones privado en Chile respecto a los montos de sus pensiones actuales. Para ello se entrevistó a 16 mujeres jubiladas y se utilizó Análisis de Contenido Cualitativo para el procesamiento de los datos. Los resultados dan cuenta de tres categorías: la percepción de estafa y el arrepentimiento en el traspaso a la AFP; discriminación de género en el ámbito laboral que impacta en la jubilación; y empobrecimiento y sufrimiento en la vida cotidiana. Se concluye que las vivencias subjetivas de las mujeres están marcadas por el sufrimiento, desamparo y el pesimismo, lo que hace difícil aspirar a una sociedad con equidad de género si el sistema de pensiones se configura como discriminatorio y poco solidario.

Dental caries is an infectious, transmissible and multifactorial disease, which leads towards a reversible and irreversible loss of minerals found in hard tissues of a tooth, caused by acids from carbohydrates fermentation due to metabolic activity of the biofilm attached to the tooth surface. Although Streptococcus mutans has been thought to be responsible for tooth decay, another bacterium named no mutans has been linked to the beginning, progression and activity of the disease in the enamel, dentine and cement. One of the methodologies put into practice to deepen the study of oral bacteria diversity related to carious cavities is oral metagenome. This methodology allows the study of whole bacterial groups by the analysis of DNA in a particular environment without the need of isolating and cultivating species, providing information about the taxonomical and phylogenetic diversity of these groups. There are different methods to study the bacterial diversity, including 16 S rRNA analysis through electrophoresis, PCR, microarrays, next generation sequence (NGS). The metagenome tool permits to recognize species that have not been able to be isolated by conventional methods. As well as identify its presence or absence in the different stages of the dental caries development, which allows a better understanding of development of the disease. The metagenome-based study has revealed an unexpected oral microbial diversity, giving information relevant to the updating of knowledge and identifies new therapeutic targets. The purpose of this review is to present the main results has brought the study of the metagenome on microbial diversity, applied specifically to the oral bacterial community in health and caries disease.

La caries es una enfermedad infecciosa, transmisible y multifactorial, que conduce a la pérdida de minerales reversible o irreversible de los tejidos duros susceptibles del diente, por acción de productos ácidos provenientes de la fermentación de los hidratos de carbono de la dieta por la actividad metabólica del biofilm adherido a la superficie dentaria. Aunque tradicionalmente se ha considerado al Streptococcus mutans como el responsable de la enfermedad, actualmente otras bacterias, denominadas no mutans, se han asociado con el inicio, progresión y actividad de la enfermedad en esmalte, dentina y cemento radicular. Para profundizar el estudio de la diversidad bacteriana oral asociada a caries dental se han aplicado diversas metodologías, dentro de las cuales destaca el estudio del metagenoma oral. Este nos permite estudiar comunidades bacterianas completas mediante el análisis del DNA, en un determinado ambiente sin necesidad de aislar y cultivar las especies, entregando información sobre la diversidad taxonómica y filogenética de estas comunidades. Existen diferentes métodos de análisis de la diversidad bactariana, entre los que tenemos el análisis del ARNr 16S mediante electroforésis, PCR, microarreglos, secuenciamiento de última generación, entre otros. El estudio del metagenoma oral ha permitido identificar especies que no han podido ser aisladas por métodos convencionales, además de identificar su presencia o ausencia en las distintas etapas del desarrollo de la enfermedad de caries dental, permitiendo un mejor conocimiento del desarrollo de esta patología. El estudio basado en el metagenoma ha dado a conocer una diversidad microbiana oral inesperada, dando información relevante para la actualización de los conocimientos y así identificar nuevos objetivos terapéuticos. El propósito de esta revisión bibliográfica es exponer los principales resultados que ha aportado el estudio del metagenoma sobre la diversidad microbiana, aplicado específicamente a la comunidad bacteriana oral.