Abstract Neglect is one of the most frequently reported forms of violence against children and adolescents, although it has rarely been explored in national studies. In this light, the present study aimed to analyze the personal social network of families involved in negligence against children and adolescents. This work takes a qualitative approach, anchored in the Paradigm of Complexity, conducted with twenty families involved in negligence against children and adolescents in a municipality in the countryside of the state of São Paulo, Brazil. Data collection took place through minimal maps of the personal social network and semi-structured interviews in January 2021. The networks were limited, with little to no interaction among the different services and sectors, and were predominantly homogeneous. Because they have many weakened ties, they are relatively unsupportive, pointing out difficulties in access to work, education, and health. Due to the characteristics of the network, the complexity of the phenomenon of neglect was identified, in which elements condition and perpetuate experiences of absence and fragility. Interprofessional and intersectoral views and actions are requested and recommended.

Resumo A negligência constitui uma das violências contra crianças e adolescentes mais notificadas, entretanto ainda pouco explorada em estudos nacionais. O objetivo deste estudo foi analisar a rede pessoal social de famílias envolvidas na negligência contra crianças e adolescentes. Estudo qualitativo, ancorado no paradigma da complexidade, realizado junto a 20 familiares envolvidos na negligência contra crianças e adolescentes em município do interior de São Paulo, Brasil. A coleta de dados se deu por mapas mínimos da rede pessoal social e entrevistas semiestruturadas em janeiro de 2021. As redes se apresentaram reduzidas, com pouca ou nenhuma articulação entre os diferentes serviços e setores e predominantemente homogêneas. Por terem muitos vínculos fragilizados, mostrou-se pouco sustentadora, apontando dificuldades no acesso a trabalho, educação e saúde. Pelas características da rede, identificou-se a complexidade do fenômeno da negligência, em que elementos condicionam e perpetuam vivências de ausências e fragilidades. Olhares e ações interprofissionais e intersetoriais são pleiteadas e recomendadas.

Abstract Mucopolysaccharidosis type IIIB (MPS IIIB) is caused by deficiency of alpha-N-acetylglucosaminidase, leading to storage of heparan sulphate. The disease is characterized by intellectual disability and hyperactivity, among other neurological and somatic features. Here we studied retrospective data from a total of 19 MPS IIIB patients from Brazil, aiming to evaluate disease progression. Mean age at diagnosis was 7.2 years. Speech delay was one of the first symptoms to be identified, around 2-3 years of age. Behavioral alterations include hyperactivity and aggressiveness, starting around age four. By the end of the first decade, patients lost acquired abilities such as speech and ability to walk. Furthermore, as disease progresses, respiratory, cardiovascular and joint abnormalities were found in more than 50% of the patients, along with organomegaly. Most common cause of death was respiratory problems. The disease progression was characterized in multiple systems, and hopefully these data will help the design of appropriate clinical trials and clinical management guidelines. alphaNacetylglucosaminidase, alphaNacetylglucosaminidase alpha N acetylglucosaminidase, acetylglucosaminidase alpha-N-acetylglucosaminidase sulphate features 1 Brazil 72 7 2 7. identified 23 3 2- aggressiveness four decade walk Furthermore progresses 50 organomegaly problems systems guidelines 5

ABSTRACT Objective: To analyze the number of hospitalizations, the length of hospital stay, and mortality due to asthma, as well as the costs to the Unified Health Care System in Brazil between 2008 and 2021. Methods: This was a cross-sectional epidemiological study using data from the Information Technology Department of the Brazilian Unified Health Care System. Proportional hospitalization and death rates were estimated per 100,000 population by age, microregion, and year. Results: The number of hospitalizations and deaths due to asthma decreased from 2008 to 2021 (205,392 vs. 55,009 and 822 vs. 327, respectively). In addition, a between-sex difference was observed in asthma-related hospitalizations in 2008, and more men were hospitalized in 2021 (51.8%). Asthma mortality rates were similar for both sexes (50.0% each) in 2008, and a slight increase was observed in women’s deaths in 2021 (52.9%). Even so, approximately one death/day and more than 55,000 hospitalizations were observed yearly, with a mean length of hospital stay of three days. Additionally, the Southeast region allocated more financial resources to asthma-related hospitalizations. Conclusions: Our results showed that the number of deaths and hospitalizations due to asthma substantially declined during the study period. Objective 200 Methods crosssectional cross sectional 100000 100 000 100,00 age microregion year Results 202 205,392 205392 205 392 (205,39 vs 55009 55 009 55,00 82 327 respectively. respectively . respectively) addition betweensex sex asthmarelated related 51.8%. 518 51.8% 51 8 (51.8%) 50.0% 500 50 0 (50.0 each womens women s 52.9%. 529 52.9% 52 9 (52.9%) so deathday day 55000 yearly days Additionally Conclusions period 20 10000 10 00 100,0 205,39 20539 39 (205,3 5500 5 55,0 32 51.8 (51.8% 50.0 (50. 52.9 (52.9% 2 1000 1 100, 205,3 2053 3 (205, 550 55, 51. (51.8 50. (50 52. (52.9 205, (205 (51. (5 (52. (20 (51 ( (52 (2

ABSTRACT The pineapple, the most important fruit in the state of Paraíba, is characterized as an important generator of employment, income and regional development. With the increase in production, challenges arise in reaching distant competitive markets, including exports, making refrigerated storage necessary. However, pineapple, a tropical fruit, is subject to Chilling Injury (CI) when stored under sub-optimal temperatures, below 12 °C, which provide internal browning (IB) and quality loss. The use of pulsed electric field (PEF), a non-thermal technology, can be an alternative in ensuring the control of IB in pineapple. Therefore, the objective of this work was to evaluate the influence of PEF application on IB, enzyme expression and activity, bioactive compounds and antioxidant activity of ‘Pérola’ pineapple. Initially, to define the best strategy, 8 kV/cm of PEF was applied to pineapples directly and indirectly (drinking water), in 4 levels of electrical pulses: 0 (control), 5, 20 and 35, proving to be the most efficient the indirect pulses. From these results, a completely randomized design was used, with indirect application of PEF at the four levels in pineapples, with 5 periods of evaluations at refrigeration at 5 °C, followed by transferring at each period for two more days to the room condition, in 4 replicants (3 fruit / rep). The indirect application of 35 pulses provided a reduction in expression and enzyme activity, IB and maintained the functional potential, being a promising alternative for the storage of pineapple under sub-optimal temperatures. Paraíba employment development production markets exports necessary However CI (CI suboptimal sub optimal temperatures 1 C °C (IB loss PEF, , (PEF) nonthermal non thermal technology Therefore ‘Pérola Pérola Initially strategy kVcm kV cm drinking water, water water) control, (control) 2 results used condition 3 ( rep. rep . rep) potential (PEF (control

Abstract BRS 700FL B3RF is an extra-long staple (ELS) upland cotton cultivar. It features exceptional fiber quality, with fiber length exceeding 33.0 mm and fiber strength above 32.5 gf tex-1. This cultivar includes transgenic events Bollgard® III and Roundup Ready Flex™, providing enhanced resistance to lepidopteran pests and tolerance to glyphosate. FL BRF B RF extralong extra long ELS (ELS quality 330 33 0 33. 325 32 5 32. tex1. tex1 tex 1. 1 tex-1 Bollgard Flex Flex™ glyphosate 3 tex-

Resumo A negligência constitui uma das violências contra crianças e adolescentes mais notificadas, entretanto ainda pouco explorada em estudos nacionais. O objetivo deste estudo foi analisar a rede pessoal social de famílias envolvidas na negligência contra crianças e adolescentes. Estudo qualitativo, ancorado no paradigma da complexidade, realizado junto a 20 familiares envolvidos na negligência contra crianças e adolescentes em município do interior de São Paulo, Brasil. A coleta de dados se deu por mapas mínimos da rede pessoal social e entrevistas semiestruturadas em janeiro de 2021. As redes se apresentaram reduzidas, com pouca ou nenhuma articulação entre os diferentes serviços e setores e predominantemente homogêneas. Por terem muitos vínculos fragilizados, mostrou-se pouco sustentadora, apontando dificuldades no acesso a trabalho, educação e saúde. Pelas características da rede, identificou-se a complexidade do fenômeno da negligência, em que elementos condicionam e perpetuam vivências de ausências e fragilidades. Olhares e ações interprofissionais e intersetoriais são pleiteadas e recomendadas. notificadas nacionais qualitativo 2 Paulo Brasil 2021 reduzidas homogêneas fragilizados mostrouse mostrou sustentadora trabalho saúde identificouse identificou fragilidades recomendadas 202

Abstract Neglect is one of the most frequently reported forms of violence against children and adolescents, although it has rarely been explored in national studies. In this light, the present study aimed to analyze the personal social network of families involved in negligence against children and adolescents. This work takes a qualitative approach, anchored in the Paradigm of Complexity, conducted with twenty families involved in negligence against children and adolescents in a municipality in the countryside of the state of São Paulo, Brazil. Data collection took place through minimal maps of the personal social network and semi-structured interviews in January 2021. The networks were limited, with little to no interaction among the different services and sectors, and were predominantly homogeneous. Because they have many weakened ties, they are relatively unsupportive, pointing out difficulties in access to work, education, and health. Due to the characteristics of the network, the complexity of the phenomenon of neglect was identified, in which elements condition and perpetuate experiences of absence and fragility. Interprofessional and intersectoral views and actions are requested and recommended. studies light approach Complexity Paulo Brazil semistructured semi structured 2021 limited sectors homogeneous ties unsupportive education health identified fragility recommended 202 20 2

ABSTRACT Zinc (Zn) is a micronutrient considered essential to plants which can be supplied through seed treatment. The treatment of soybean [Glycine max (L.) Merr.] seeds with Zn, however, is still not well known as regards the uptake and mobilization dynamics of the nutrient during the germination process. This study aimed to evaluate the uptake and distribution dynamics of Zn applied to soybean seeds at two levels of vigor during germination using X-ray micro-fluorescence spectroscopy (µ-XRF). Zinc treatments corresponded to 0, 2, 4 and 8 g of Zn per kg of seeds. High and low vigor seeds that had been treated were located appropriately so as to promote germination. Zn intensity measurements with µ-XRF were taken in different parts (“regions”) of the seeds (seed coat, cotyledon, and embryonic axis) after 8, 16 and 24 h of imbibition and seedlings (primary root, hypocotyl, plumule, cotyledon, and seed coat) after 48, 72 and 96 h of germination. High vigor seeds showed higher Zn intensity in the embryonic axis in the first 16 h, while low vigor seeds showed higher intensity after 24 h. After 48, 72 and 96 h of germination low vigor seedlings showed higher Zn intensity than high vigor seedlings in the primary root. It was concluded that µ-XRF is an efficient technique for identifying variances in the dynamics of Zn uptake and mobilization during the germination of soybean seeds with different vigor levels.

Resumen La discusión de este texto, elaborado a partir de una investigación doctoral realizada en una escuela pública municipal de Rio Grande do Sul, pretende comprender cómo la autoetnografía crítica constituye un proceso de investigación teórico-metodológico que permite la reconstrucción de la práctica docente. Para ello, presentamos el aporte teórico-metodológico de la autoetnografía crítica al relacionar la investigación autoetnográfica con la fundamentación conceptual de la teoría crítica. En la secuencia, utilizamos narrativas de experiencias docentes para identificar cómo los procesos recursivos y reflexivos, ambos sustentados en la reflexión crítica, tienen implicaciones directas en la formación y práctica docente del investigador. En las consideraciones finales, nosotros discutimos la autoetnografía crítica como una experiencia doblemente transformadora, en tanto implica procesos graduales y simultáneos de lectura del mundo y de reconstrucción de la práctica docente que se dan a lo largo de la propia investigación. texto Sul teóricometodológico teórico metodológico ello secuencia reflexivos investigador finales transformadora

Resumo A discussão deste texto, elaborada a partir de uma pesquisa de doutorado realizada em uma escola pública municipal do Rio Grande do Sul, tem por objetivo compreender como a autoetnografia crítica constitui um processo teórico-metodológico de pesquisa que permite reconstruir a prática docente. Para isso, apresentamos o aporte teórico-metodológico da autoetnografia crítica ao relacionar a pesquisa autoetnográfica com a fundamentação conceitual da teoria crítica. Na sequência, utilizamos narrativas de experiências docentes para identificar como os processos recursivos e reflexivos, ambos sustentados na reflexão crítica, têm implicações diretas na formação e na prática docente do pesquisador. Nas considerações finais, dialogamos sobre a autoetnografia crítica como experiência duplamente transformadora, pois envolve processos gradativos e simultâneos de leituras de mundo e reconstrução da prática docente que ocorrem ao longo da própria investigação. texto Sul teóricometodológico teórico metodológico isso sequência reflexivos pesquisador finais transformadora investigação

Abstract The discussion of this text, elaborated from a doctoral research project carried out in a municipal public school in Rio Grande do Sul, aims to understand how critical autoethnography constitutes a theoretical-methodological research process that allows the reconstruction of the teaching practice. For this, we present the theoretical-methodological contribution of critical autoethnography by relating autoethnographic research with the conceptual foundation of critical theory. , We then use narratives of teaching experiences to identify how recursive and reflective processes, both supported by critical reflection, have direct implications for the researcher's teaching training and practice. In the final considerations, we discuss critical autoethnography as a doubly transforming experience, as it involves gradual and simultaneous processes of reading the world and reconstructing the teaching practice that occurred throughout the investigation itself. text Sul theoreticalmethodological theoretical methodological theory reflection researchers researcher s considerations experience itself

RESUMEN Objetivo: revisar las terminologías y aplicaciones de la taxonomía de la Ciencia Abierta, para construir una versión más completa, que represente el conocimiento en torno al tema, de acuerdo con el escenario actual de la comunicación científica y las recomendaciones de la Organización de las Naciones Unidas para la Educación, la Ciencia y la Cultura (Unesco). Método: se trata de una investigación exploratoria con un enfoque deductivo. El primer paso fue la revisión de las taxonomías, con las 12 personas dedicadas a la investigación, que se reunieron semanalmente, para las discusiones conceptuales y epistemológicas relacionadas con la Ciencia Abierta y las definiciones metodológicas y de procedimiento para la realización del estudio. Resultados: como resultado de los análisis, se elaboró una taxonomía para ser evaluada por las personas expertas. Para ello, se envió a 68 personas expertas un cuestionario con preguntas abiertas sobre cada eje principal de la taxonomía. Se obtuvieron 21 respuestas que cooperaron con la modelización y exposición de los términos de la nueva propuesta de taxonomía. La nueva taxonomía tiene 10 componentes de nivel principal y un total de 96 etiquetas. Conclusiones: la percepción de los expertos puso de manifiesto un panorama congruente con las recomendaciones de la Unesco y el escenario actual de la Ciencia Abierta. Objetivo completa tema Educación Unesco. . (Unesco) Método deductivo taxonomías 1 semanalmente estudio Resultados análisis ello 6 2 9 etiquetas Conclusiones (Unesco

RESUMO Objetivo: revisar as terminologias e aplicações da taxonomia de Ciência Aberta para a construção de uma versão mais abrangente, que represente o conhecimento em volta do tema, em conformidade com o cenário atual da comunicação científica e com as recomendações da Organização das Nações Unidas para a Educação, a Ciência e a Cultura (Unesco). Método: trata-se de uma pesquisa do tipo exploratória com abordagem dedutiva. A primeira etapa foi a revisão das taxonomias, com 12 pesquisadores1 que se reuniram, semanalmente, para discussões conceituais e epistemológicas relacionadas à Ciência Aberta, e definições metodológicas e procedimentais para a realização do estudo. Resultados: como resultado das análises, foi desenvolvida uma taxonomia para ser avaliada pelos especialistas. Para isso, foi enviado um questionário com perguntas abertas, sobre cada eixo principal da taxonomia, para 68 especialistas. Foram obtidas 21 respostas que cooperaram com a modelagem e exposição dos termos para a nova taxonomia. A taxonomia oriunda desse processo de revisão tem 10 facetas de nível principal e o total de 96 rótulos. Conclusões: a percepção dos especialistas trouxe à tona um panorama congruente com as recomendações da Unesco e do atual cenário da Ciência Aberta. Objetivo abrangente tema Educação Unesco. . (Unesco) Método tratase trata dedutiva taxonomias 1 pesquisadores reuniram semanalmente estudo Resultados análises isso abertas 6 2 9 rótulos Conclusões (Unesco

ABSTRACT Objective: To review the terminologies and applications of Open Science taxonomy to build a more comprehensive version that represents the knowledge surrounding the subject in accordance with the current scenario of scientific communication and the recommendations of the United Nations Educational, Scientific and Cultural Organization (UNESCO). Method: This is a qualitative investigation with an exploratory focus. The first step taken was the revision of existing taxonomies by 12 researchers1, who met weekly for conceptual and epistemological discussions related to Open Science and methodological and procedural definitions for the realization of the study. Results: As a result of these discussions, a proposed taxonomy was developed for revision by experts. Evaluation of this taxonomy was carried out using a questionnaire with open questions about each main axis of the taxonomy, which was sent to 68 specialists. A total of 21 responses that analyzed the modeling and exposition of terms in the proposed taxonomy were received. The final taxonomy has 10 main-level facets and a total of 96 labels. Conclusions: the responses of the experts brought to light a panorama consistent with UNESCO recommendations and the current scenario of Open Science. Objective Educational UNESCO. . (UNESCO) Method focus 1 researchers1 researchers study Results 6 specialists 2 received mainlevel level 9 labels Conclusions (UNESCO

Abstract The present study aimed for the molecular detection of Rickettsia spp. in ticks collected from military training areas in southeastern Brazil. Previously, a total of 9,374 free-living ticks in 66 military instruction areas of five Military Organizations (MOs) were collected. From these, a sample of 1,885 ticks was used for molecular analysis..DNA extraction was performed using the “HotSHOT” technique, and PCR was performed using the Rickettsia spp. gltA, 17kDa and ompA genes. It was found that 11 samples produced DNA sequences of sizes compatible with the Rickettsia spp. gltA and 17kDa gene and two of these, also for ompA, with a prevalence of 0.58% (11/1885). Analyses of amplified fragments of gltA identified the samples as Rickettsia bellii in seven nymphs of Amblyomma dubitatum and one nymph of Amblyomma sculptum, and identified samples as Rickettsia sp. in two nymphs of A. dubitatum and one of A. sculptum. This finding warns the possibility of the risk of exposure of military personnel to ticks infected with Rickettsia spp. during training. spp Brazil Previously 9374 9 374 9,37 freeliving free living 6 MOs (MOs these 1885 1 885 1,88 analysisDNA analysis HotSHOT “HotSHOT technique kDa genes 058 0 58 0.58 11/1885. 111885 11/1885 . (11/1885) sculptum sp A 937 37 9,3 188 88 1,8 05 5 0.5 11188 11/188 (11/1885 93 3 9, 18 8 1, 0. 1118 11/18 (11/188 111 11/1 (11/18 11/ (11/1 (11/ (11 (1 (

RESUMEN El desarrollo agrícola exige una mayor adopción de maquinaria por parte de los productores para evitar el daño a la salud de los trabajadores por el exceso de ruido. En este escenario, este estudio presenta análisis utilizando geoestadística y Control Estadístico de Procesos (SPC) en el mapeo de la variabilidad espacial de la magnitud del ruido emitido por un microtractor para identificar zonas saludables para los trabajadores. El estudio se llevó a cabo en la Universidad Federal de Lavras (UFLA), donde los niveles de ruido se recolectaron en puntos distribuidos en una cuadrícula de muestra regular de 2,0×2,0 m alrededor de la máquina. La dependencia espacial del ruido se analizó ajustando el semivariograma de tipo onda e interpolando por kriging ordinario y el SPC a través de cartas de control individuales. Fue posible observar valores de ruido superiores a 85 dB(A) en un radio de hasta 6 m alrededor del tractor en funcionamiento. El valor máximo de 91 dB(A) se obtuvo desde el asiento del operador, permitiendo así una exposición diaria máxima de 3,5 h. Además, se observó que las personas ubicadas a distancias mayores a 4 m del microtractor no necesitan usar equipo de protección personal para una exposición de 8 h de trabajo.

ABSTRACT Agricultural development requires greater adoption of machinery by producers to avoid damage to the worker's health due to excessive noise. In this scenario, this study aimed to analyze the noise magnitude emitted by a micro-tractor using geostatistics and Statistical Process Control (SPC) in mapping spatial variability to identify healthy zones for workers. The study was carried out at the Federal University of Lavras (UFLA), where noise levels were collected at points distributed in a regular 2.0×2.0 m sample grid around the machine. The spatial dependence of noise was analyzed by adjusting the wave-type semivariogram and interpolating by ordinary kriging and the SPC through individual control charts. It was possible to observe alarming noise values above 85 dB(A) in a radius of up to 6 m around the tractor in operation. The maximum value of 91 dB(A) was obtained from the operator's seat, thus allowing maximum daily exposure of 3.5 h. In addition, it was observed that people located at distances greater than 4 m from the micro-tractor do not need to wear personal protective equipment for an exposure of 8 h of work.

Resumo Originalidade/contribuição: está ancorado numa discussão por eixos, onde se debate um período histórico marcado por transformações intensas na vida das classes populares, quando os investimentos governamentais na indústria denotaram um aumento da migração rural-urbana e a formação de uma massa de trabalhadores analfabetos nas cidades brasileiras. Método: O método de pesquisa indicado para este estudo foi o levantamento, sistematização e análise bibliográfica, baseada em descritores próximos do tópico e período determinado, utilizando os instrumentos de análise de conteúdo para a elaboração do artigo. Estratégias/coleta de informações: Para A recolha de informação foi baseada em inquéritos bibliográficos em colecções brasileiras e estrangeiras que trataram da discussão sobre sensibilização e práticas educativas no período específico. Conclusões: Observa-se que as mudanças que ocorreram ao longo das décadas actuaram directamente na estruturação da teoria da educação de Paulo Freire. Como crítica à educação dos trabalhadores, o conceito de consciência e prática educacional foram consolidados como a base da pedagogia freireana e são progressivamente desenvolvidos e tornados mais complexos no trabalho do autor. Os conceitos enunciados oferecem subsídios às análises actuais da função social da escola e da formação humana.

Resumen Objetivo: Este artículo tiene como objetivo discutir el concepto de conciencia y práctica educativa en la evolución del pensamiento sobre la educación dirigida a la clase popular, en la obra de Paulo Freire, con contribuciones teóricas para reflexiones sobre los factores políticos, económicos y sociales brasileños, en las décadas de 1950 - 1960. Originalidad/aporte: se ancla en una discusión por ejes, donde se debate un período histórico marcado por intensas transformaciones en la vida de las clases populares, cuando las inversiones gubernamentales en la industria denotaron un aumento de la migración rural-urbana y la formación de una masa de trabajadores analfabetos en las ciudades brasileñas. Método: El método de investigación enumerado para este estudio fue la encuesta, la sistematización y el análisis bibliográfico, a partir de descriptores cercanos al tema y período determinado, utilizando las herramientas del análisis de contenido para la elaboración del artículo. Estrategias de recolección de información: La recopilación de información se basó en levantamientos bibliográficos en colecciones brasileñas y extranjeras que trataron la discusión sobre la conciencia y las prácticas educativas en el período específico. Conclusión: se observa que los cambios ocurridos a lo largo de las décadas actuaron directamente en la estructuración de la teoría de la educación de Paulo Freire. Como crítica a la educación de los trabajadores, el concepto de conciencia y práctica educativa, se consolidaron como base de la pedagogía freireana y se desarrollan y complejizan progresivamente en la obra del autor. Los conceptos enunciados ofrecen subsidios a los análisis actuales sobre la 247 función social de la escuela y la formación humana.

Abstract Objective: This article aims to discuss the concept of awareness and educational practice in the evolution of thinking about education aimed at the popular class, in the works of Paulo Freire, with theoretical contributions for reflections on Brazilian political, economic and social factors, in the decades of 1950 - 1960. Originality/contribution: The original article is anchored in a discussion by axes, where a historical period marked by intense transformations in the life of the popular classes is debated, when government investments in industry denoted an increase in rural-urban migration and the formation of a mass of illiterate workers in Brazilian cities. Method: The research method listed for this study was a survey, systematization and bibliographic analysis, from descriptors close to the theme and determined period, using the tools of content analysis for the elaboration of the article. Information strategy/data collection: The collection of information was based on bibliographic surveys in Brazilian and foreign collections that dealt with the discussion about awareness and educational practices in the specific period. Conclusions: As conclusions, it is observed that the changes that took place over the decades acted directly in the structuring of Paulo Freires theory on education. As a criticism of the education given to workers, the concept of awareness and educational practice, were consolidated as the basis of Freirean pedagogy and are progressively developed and complexified in the authors works. The enunciated concepts offer subsidies to the current analyzes on the social function of the school and the human formation.

ABSTRACT Introduction: Overweight negatively impacts the cardiovascular system and osteomyoarticular, promoting pain in the joints of the lower limbs. Therefore, strategies have been applied to reduce overweight through lifestyle changes. Objective: To investigate the effects of two multidisciplinary intervention programs on the health-related physical fitness of obese women with pain symptoms in the knees. Methods: Women between 40 and 59 years of age with obesity (n=59) were evaluated pre- and post-intervention in terms of anthropometry, body composition, physical fitness, level of disability in the knee and hip, and health-related quality of life. A randomized experimental study of parallel groups was conducted for 8 weeks, using two resistance exercise programs and food reeducation. All participants received the same nutritional interventions. For physical exercises, the participants were randomized into two groups: G1, the “strength group” using machines (n=30), and G2, the “body weight” group (n=29). Twenty-eight women (G1, n=18; G2, n=10) were included in the final analyses. This study was approved by Ethics Local Committee. The groups and time were evaluated using two-way analysis of variance with repeated measures. A p<0.05 was assumed for all analyses. Results: A time effect was identified, with higher values for maximum isometric lumbar traction strength after the intervention period in both groups (p<0.05). However, no significant differences were identified among the other variables investigated (p>0.05). Conclusion: The absence of significant results for all variables, except maximum isometric lumbar traction, may be justified by the moderate adherence of the participants to interventions (approximately 59%-66%) since the study was conducted during the period of social isolation (COVID-19). However, it is believed that the intervention models were positive in maintaining the variables studied.

RESUMEN Introducción: El sobrepeso afecta negativamente al sistema cardiovascular y al osteomioarticular, favoreciendo el dolor en las articulaciones de las extremidades inferiores. Por lo tanto, se han aplicado estrategias para reducir el sobrepeso a través de cambios en el estilo de vida. Objetivo: investigar los efectos de dos programas de intervención multidisciplinares sobre la aptitud física relacionada con la salud de mujeres obesas con síntomas de dolor en las rodillas. Métodos: Se evaluó a mujeres entre 40 y 59 años con obesidad (n=59) en el tiempo pre y post intervención en antropometría, composición corporal, aptitud física, nivel de discapacidad en rodilla y cadera y calidad de vida relacionada con la salud. Se realizó un ensayo clínico aleatorizado de grupos paralelos, utilizando dos programas de ejercicio de resistencia y reeducación alimentaria, durante ocho semanas. Todos los participantes recibieron el mismo contenido de intervención nutricional y para ejercicios físicos se aleatorizaron en dos grupos, G1 siendo el "grupo de fuerza" utilizando máquinas (n=30), y G2 siendo el grupo de "entrenamiento funcional" (n=29). Veintiocho mujeres (G1=18 + G2=10) fueron incluidas en los análisis finales. Este estudio fue aprobado por el Comité Local de Ética. Los grupos y el tiempo se evaluaron mediante análisis bidireccional de la varianza, con medidas repetidas. Se asumió una p < 0,05 para todos los análisis. Resultados: se identificó un efecto de tiempo, con valores más altos para la fuerza máxima de tracción lumbar isométrica (MILTS), luego del período de intervención en ambos grupos (p < 0.05). Sin embargo, para las otras variables investigadas, no se identificaron diferencias significativas (p > 0.05). Conclusión: La ausencia de resultados significativos para todas las variables, excepto FIMTL, puede estar justificada por la adherencia moderada de los participantes a las intervenciones (~ 59% a 66%) ya que el estudio se realizó durante el período de aislamiento social (COVID-19). Sin embargo, se cree que los modelos de intervención fueron positivos en el mantenimiento de las variables estudiadas.

ABSTRACT Background: An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant was detected in the psychiatric ward of a general hospital in Brasília, Brazil. Methods: We report the investigation, clinical outcomes, viral sequencing, and control measures applied to outbreak containment. Results: The overall attack rate was 95% (23/24) in a period of 13 days. Among the cases, 78% (18/23) were vaccinated and 17% (4/23) required intensive care. The Omicron variant was isolated from the 19 sequenced samples. Conclusions: The findings highlight the potential harm that highly transmissible variants may generate among hospitalized populations, particularly those with comorbidities.