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ABSTRACT Background: Driving pressure has been suggested to be the main driver of ventilator-induced lung injury and mortality in observational studies of acute respiratory distress syndrome. Whether a driving pressure-limiting strategy can improve clinical outcomes is unclear. Objective: To describe the protocol and statistical analysis plan that will be used to test whether a driving pressure-limiting strategy including positive end-expiratory pressure titration according to the best respiratory compliance and reduction in tidal volume is superior to a standard strategy involving the use of the ARDSNet low-positive end-expiratory pressure table in terms of increasing the number of ventilator-free days in patients with acute respiratory distress syndrome due to community-acquired pneumonia. Methods: The ventilator STrAtegy for coMmunIty acquired pNeumoniA (STAMINA) study is a randomized, multicenter, open-label trial that compares a driving pressure-limiting strategy to the ARDSnet low-positive end-expiratory pressure table in patients with moderate-to-severe acute respiratory distress syndrome due to community-acquired pneumonia admitted to intensive care units. We expect to recruit 500 patients from 20 Brazilian and 2 Colombian intensive care units. They will be randomized to a driving pressure-limiting strategy group or to a standard strategy using the ARDSNet low-positive end-expiratory pressure table. In the driving pressure-limiting strategy group, positive end-expiratory pressure will be titrated according to the best respiratory system compliance. Outcomes: The primary outcome is the number of ventilator-free days within 28 days. The secondary outcomes are in-hospital and intensive care unit mortality and the need for rescue therapies such as extracorporeal life support, recruitment maneuvers and inhaled nitric oxide. Conclusion: STAMINA is designed to provide evidence on whether a driving pressure-limiting strategy is superior to the ARDSNet low-positive end-expiratory pressure table strategy for increasing the number of ventilator-free days within 28 days in patients with moderate-to-severe acute respiratory distress syndrome. Here, we describe the rationale, design and status of the trial. Background ventilatorinduced induced pressurelimiting limiting unclear Objective endexpiratory end expiratory lowpositive low ventilatorfree free communityacquired community Methods (STAMINA multicenter openlabel open label moderatetosevere moderate severe units 50 Outcomes inhospital hospital support oxide Conclusion Here rationale 5

RESUMO Contexto: Em estudos observacionais sobre a síndrome do desconforto respiratório agudo, sugeriu-se que a driving pressure é o principal fator de lesão pulmonar induzida por ventilador e de mortalidade. Não está claro se uma estratégia de limitação da driving pressure pode melhorar os desfechos clínicos. Objetivo: Descrever o protocolo e o plano de análise estatística que serão usados para testar se uma estratégia de limitação da driving pressure envolvendo a titulação da pressão positiva expiratória final de acordo com a melhor complacência respiratória e a redução do volume corrente é superior a uma estratégia padrão envolvendo o uso da tabela de pressão positiva expiratória final baixa do protocolo ARDSNet, em termos de aumento do número de dias sem ventilador em pacientes com síndrome do desconforto respiratório agudo devido à pneumonia adquirida na comunidade. Métodos: O estudo STAMINA (ventilator STrAtegy for coMmunIty acquired pNeumoniA) é randomizado, multicêntrico e aberto e compara uma estratégia de limitação da driving pressure com a tabela de pressão positiva expiratória final baixa do protocolo ARDSnet em pacientes com síndrome do desconforto respiratório agudo moderada a grave devido à pneumonia adquirida na comunidade internados em unidades de terapia intensiva. Esperamos recrutar 500 pacientes de 20 unidades de terapia intensiva brasileiras e duas colombianas. Eles serão randomizados para um grupo da estratégia de limitação da driving pressure ou para um grupo de estratégia padrão usando a tabela de pressão positiva expiratória final baixa do protocolo ARDSnet. No grupo da estratégia de limitação da driving pressure, a pressão positiva expiratória final será titulada de acordo com a melhor complacência do sistema respiratório. Desfechos: O desfecho primário é o número de dias sem ventilador em 28 dias. Os desfechos secundários são a mortalidade hospitalar e na unidade de terapia intensiva e a necessidade de terapias de resgate, como suporte de vida extracorpóreo, manobras de recrutamento e óxido nítrico inalado. Conclusão: O STAMINA foi projetado para fornecer evidências sobre se uma estratégia de limitação da driving pressure é superior à estratégia da tabela de pressão positiva expiratória final baixa do protocolo ARDSnet para aumentar o número de dias sem ventilador em 28 dias em pacientes com síndrome do desconforto respiratório agudo moderada a grave. Aqui, descrevemos a justificativa, o desenho e o status do estudo. Contexto sugeriuse sugeriu clínicos Objetivo ARDSNet Métodos ventilator pNeumoniA randomizado 50 2 colombianas Desfechos resgate extracorpóreo inalado Conclusão Aqui justificativa 5

https://doi.org/10.62675/2965-2774.20240210-en

Nucleated red blood cell: a feasible quality parameter of cord blood units cell
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Kondo, Andrea Tiemi

; Alvarez, Kelen Cristina Arcuri

; Cipolletta, Andrea Neri Folchini

; Sakashita, Araci Massami

; Kutner, Jose Mauro

Hematology, Transfusion and Cell Therapy

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2024, Volume 46 N. 3 Pages 221 - 227

Abstract: En | Text: En | PDF: En

Abstract Introduction Umbilical cord blood is an alternative source of hematopoietic progenitor cells for bone marrow transplantation; however, it is associated with a higher graft failure rate. The presence of a high rate of nucleated red blood cells (NRBCs) seems to be related to a greater capacity for engraftment, although is also associated with fetal distress conditions. We analyzed the correlation of the NRBC with quality parameters and its association with the utilization score of a cord blood unit. Study design and method Data of 3346 units collected in a public cord blood bank from May 2010 to December 2017 were analyzed, retrospectively, to identify factors associated with an increased number of nucleated red blood cells and its correlation with the engraftment capacity measured through total nucleated cells (TNCs) and CD34 positive cells. We also evaluated the utilization score of these units and identified an NRBC cutoff associated with a higher score. Results The median volume collected was 104 mL (42-255), the pre-processing TNC count was 144.77 × 107 (95.46-477.18), the post-processing TNC count was 119.44 × 107 (42.7-477.18), the CD34 count was 4.67 × 106 (0.31-48.01), the NRBC count was 5 (0-202) and the utilization score was 0.0228 (0.00143-0.9740). The NRBC showed a correlation with the collected volume, TNC and CD34 positive cells and a higher utilization score and the receiver operating characteristic (ROC) curve analysis identified the five NRBC/100 leukocytes cutoff that correlates better with the probability of use. No association with pathological conditions and the NRBC rate was observed. Conclusions The NRBC is a feasible parameter for the screening of the cord blood unit (CBU) and the minimum cutoff of five NRBC/100 leukocytes can be a strategy in conjunction with the TNC to identify better units for cord blood bank sustainability. transplantation however NRBCs (NRBCs 334 201 retrospectively TNCs (TNCs CD CD3 10 42255, 42255 42 255 , (42-255) preprocessing pre processing 14477 144 77 144.7 95.46477.18, 954647718 95.46 477.18 95 46 477 18 (95.46-477.18) postprocessing post 11944 119 44 119.4 42.7477.18, 42747718 42.7 7 (42.7-477.18) 467 4 67 4.6 0.3148.01, 0314801 0.31 48.01 0 31 48 01 (0.31-48.01) 0202 202 (0-202 00228 0228 0.022 0.001430.9740. 00014309740 0.00143 0.9740 . 00143 9740 (0.00143-0.9740) ROC (ROC NRBC100 100 NRBC/10 use observed CBU (CBU sustainability 33 20 1 4225 25 (42-255 1447 14 144. 46477 95.46477.18 95464771 9546 95.4 47718 477.1 9 47 (95.46-477.18 1194 11 119. 7477 42.7477.18 4274771 427 42. (42.7-477.18 6 4. 3148 0.3148.01 031480 031 0.3 4801 48.0 3 (0.31-48.01 020 (0-20 0022 022 0.02 001430 0.001430.9740 0001430974 000143 0.0014 09740 0.974 0014 974 (0.00143-0.9740 NRBC10 NRBC/1 2 422 (42-25 4647 95.46477.1 9546477 954 95. 4771 477. (95.46-477.1 747 42.7477.1 427477 (42.7-477.1 314 0.3148.0 03148 03 0. 480 48. (0.31-48.0 02 (0-2 002 0.0 0.001430.974 000143097 00014 0.001 0974 0.97 001 97 (0.00143-0.974 NRBC1 NRBC/ (42-2 464 95.46477. 954647 (95.46-477. 74 42.7477. 42747 (42.7-477. 0.3148. 0314 (0.31-48. (0- 00 0.001430.97 00014309 0001 0.00 097 0.9 (0.00143-0.97 (42- 95.46477 95464 (95.46-477 42.7477 4274 (42.7-477 0.3148 (0.31-48 (0 0.001430.9 0001430 000 09 (0.00143-0.9 (42 95.4647 (95.46-47 42.747 (42.7-47 0.314 (0.31-4 ( 0.001430. (0.00143-0. (4 95.464 (95.46-4 42.74 (42.7-4 (0.31- 0.001430 (0.00143-0 (95.46- (42.7- (0.31 (0.00143- (95.46 (42.7 (0.3 (0.00143 (95.4 (42. (0. (0.0014 (95. (0.001 (95 (0.00 (9 (0.0

https://doi.org/10.1016/j.htct.2023.01.009

Current landscape of clinical use of ex vivo expanded natural killer cells for cancer therapy
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Azevedo, Júlia Teixeira Cottas de

; Godoy, Juliana Aparecida Preto de

; Souza, Cláudia de

; Sielski, Micheli Severo

; Coa, Larissa Leggieri

; Barbosa Júnior, Augusto

; Kerbauy, Lucila Nassif

; Kondo, Andrea Tiemi

; Okamoto, Oswaldo Keith

; Hamerschlak, Nelson

; Kutner, José Mauro

; Paiva, Raquel de Melo Alves

einstein (São Paulo)

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2024, Volume 22 elocation eRW0612

Abstract: En | Text: En | PDF: En

ABSTRACT Natural Killer cells are immune leukocytes required for responses against tumor cells and virus-infected cells. In the last decade, natural killer cells have emerged as promising tools in cancer therapy, and clinical studies on patients treated with natural killer cells have revealed increased rates of disease-free survival. In this article, we review results from the major clinical trials that have used natural killer cells for cancer treatment, including their global distribution. We also discuss the major mechanisms of natural killer cell activation and expansion and focus on the advantages and disadvantages of each mechanism for clinical applications. Although natural killer cells can be isolated from several sources, primary natural killer cells are most commonly used in clinical trials. However, the frequency of natural killer cells available in peripheral and cord blood is low, necessitating development of methods for expansion of natural killer cells for clinical use. The development of a platform for the expansion of large-scale good manufacturing practice-compliant natural killer cells has limitations as several methods for natural killer cell activation and expansion yield conflicting results. Only techniques using feeder cells can produce large numbers of cells, allowing the “off-the-shelf” use of natural killer cells. However, advances in cell culture have supported the development of feeder-free platforms for natural killer cell expansion, which is fundamental for improving the safety of this type of cell therapy. virusinfected virus infected decade therapy diseasefree disease free survival article treatment distribution applications sources However low largescale scale practicecompliant practice compliant offtheshelf off shelf “off-the-shelf feederfree

https://doi.org/10.31744/einstein_journal/2024rw0612

Angioedema after rt-PA infusion led to airway emergency: a case report of rescue treatment with fresh frozen plasma rtPA rt PA emergency
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Mazzoli, Carlo Alberto

; D’Angelo, Maura Ida

; Simonetti, Luigi

; Cirillo, Luigi

; Zini, Andrea

; Gentile, Mauro

; Gordini, Giovanni

; Coniglio, Carlo

Brazilian Journal of Anesthesiology

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apr 2023, Volume 73 N. 2 Pages 223 - 226

Abstract: En | Text: En | PDF: En

Abstract The authors report the case of a 71-year-old woman presented to the Emergency Department with acute ischemic stroke. She was treated with rt-PA and interventional endovascular revascularization and developed rapidly progressing angioedema that led to emergency intubation. The standard treatment was not very effective and the swelling improved after infusion of fresh frozen plasma. Angioedema after rt-PA infusion could be a life-threatening emergency that requires quick airway management by skilled professionals. As this condition is triggered by several factors, such as unregulated histamine and bradykinin production, the traditional treatment recommended by the guidelines may not be sufficient and the use of FFP can be considered as a safe and valuable aid. 71yearold yearold 71 year old stroke rtPA rt PA intubation plasma lifethreatening life threatening professionals factors production aid 7

https://doi.org/10.1016/j.bjane.2021.04.023

NITROUS OXIDE EMISSIONS FROM A TYPICAL ARGIUDOL SOIL WITH ORGANIC AND CHEMICAL AMENDMENTS
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Noemí Cosentino, Vanina Rosa

; Pérez, Mónica Gabriela

; Ostinelli, Mauro Ezequiel

; Romaniuk, Romina Ingrid

; Mórtola, Natalia Andrea

; Rizzo, Pedro Federico

; Costantini, Alejandro Oscar

Ciencia del suelo

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jun 2022, Volume 40 N. 1 Pages 102 - 111

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN El aumento de las fuentes de fertilización será necesario para satisfacer la creciente demanda de alimentos en todo el mundo. Por este motivo, las enmiendas orgánicas surgen como una alternativa a los fertilizantes sintéticos. El compostaje de residuos orgánicos estabiliza el contenido de nitrógeno (N) y retrasa la liberación de N al suelo. La aplicación de enmiendas compostadas al suelo podría reducir las pérdidas de N, incluido el óxido nitroso (N2O), un gas de efecto invernadero con gran potencial de calentamiento global. El objetivo de este trabajo fue evaluar la emisión de N2O desde un suelo Argiudol típico luego de aplicar un fertilizante sintético tradicional, guano de ave crudo y compostado y un suelo control. Las tasas emisión de N2O acumuladas durante los 32 días que duro el ensayo fueron 1273, 965, 423 y 244 g de N2O-N ha-1 desde el suelo con aplicación de urea, guano de ave, compost de guano de ave y control, respectivamente. Nuestros resultados sugieren que la aplicación de compost de guano al suelo produce menores emisiones de N2O que la aplicación de guano de ave crudo o de urea. La presencia de compuestos más estabilizados en el compost de guano disminuye la disponibilidad de nitrato del suelo.

ABSTRACT Diversification in fertilizer sources will be necessary to meet the growing demand for food worldwide. For this reason, organic amendments emerge as a synthetic fertilizers alternative. Composting organic waste stabilizes the nitrogen (N) content and delays N release to the soil. Applying composted amendments to the soil could reduce the losses of N, including nitrous oxide (N2O), a greenhouse gas with great potential for global warming. The objective of this work was to evaluate the N2O emission in typical Argiudol soil after applying a traditional synthetic fertilizer, raw poultry manure, composted poultry manure and control soil. Cumulative N2O emission rates during the 32 days of the trial were 1273, 965, 423, and 244 g N2O-N/ha-1 from the soil using urea, poultry manure, composted poultry manure, and control, respectively. Our results suggest that the application of composted poultry manure to the soil produces lower N2O emissions than the application of raw poultry manure or urea. The presence of more stabilized compounds in the composted manure decreases the soil nitrate availability.

Chagas disease mortality during the coronavirus disease 2019 pandemic: A Brazilian referral center experience
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Hasslocher-Moreno, Alejandro Marcel

; Saraiva, Roberto Magalhães

; Silva, Gilberto Marcelo Sperandio da

; Xavier, Sergio Salles

; Sousa, Andréa Silvestre de

; Costa, Andrea Rodrigues da

; Mendes, Fernanda de Souza Nogueira Sardinha

; Mediano, Mauro Felippe Felix

Revista da Sociedade Brasileira de Medicina Tropical

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2022, Volume 55 elocation e0562-2021

Abstract: En | Text: En | PDF: En

ABSTRACT Background We investigated the mortality rates of patients with Chagas disease (CD) during the coronavirus disease 2019 (COVID-19) pandemic and assessed the association between this mortality and CD clinical presentation and comorbidities. Methods: This was an observational retrospective study with clinical data retrieved from medical records. Results: Comorbidities were more prevalent among patients who died from COVID-19 than those who died from other causes. The proportion of patients according to CD clinical presentation was similar between the two groups. Conclusions: The prevalence of comorbidities seems to be related to a poorer prognosis in CD and COVID-19.

https://doi.org/10.1590/0037-8682-0562-2021

Report of a clinical and laboratory management of cell therapy for knee cartilage in the face of mycoplasma contamination
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Zorzi, Alessandro Rozim

; Antonioli, Eliane

; Godoy, Juliana Aparecida Preto de

; Okamoto, Oswaldo Keith

; Kondo, Andrea Tiemi

; Kutner, José Mauro

; Kaleka, Camila Cohen

; Cohen, Moisés

; Ferretti, Mario

einstein (São Paulo)

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2022, Volume 20 elocation eRC6918

Abstract: En | Text: En | PDF: En

ABSTRACT To describe a case of autologous chondrocyte implantation after cell culture contamination by Mycoplasma pneumoniae and the measures taken to successfully complete cell therapy in a patient with focal chondral lesion. A 45-year-old male patient, complaining of chronic pain on the knee and no history of trauma. He had a chondral lesion in the trochlear region of the femur and clinical tests compatible with pain in the anterior compartment of the knee. Conservative treatment failed to alleviate symptoms. Surgical treatment was indicated, but due to the size of the lesion, membrane-assisted autologous chondrocyte implantation was the technique of choice. Cartilage biopsies were collected from the intercondylar region of the distal femur. After isolation, chondrocytes were expanded ex vivo in a trained laboratory, for three weeks, and seeded onto a commercially available collagen membrane prior to implantation in the knee. Two days before surgery, a cell culture sample tested positive for Mycoplasma pneumoniae. The source of contamination was found to be autologous blood serum, extracted from the patient´s peripheral vein, and used to supplement the cell culture medium. After treating the patient with antibiotics, all procedures were repeated and the new final cell product, free from contaminants, was successfully implanted. We discuss the strategies available to deal with this situation, and describe the results of this particular case, which led to modifications in the autologous chondrocyte implant protocol.

https://doi.org/10.31744/einstein_journal/2022rc6918

Matrix-assisted autologous chondrocyte transplantation for treatment of focal chondral lesions in the knee: the Hospital Israelita Albert Einstein experience
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Zorzi, Alessandro Rozim

; Antonioli, Eliane

; Kaleka, Camila Cohen

; Cohen, Moisés

; Godoy, Juliana Aparecida Preto de

; Kondo, Andrea Tiemi

; Kutner, José Mauro

; Lenza, Mario

; Ferretti, Mario

einstein (São Paulo)

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2022, Volume 20 elocation eAO6819

Abstract: En | Text: En | PDF: En

ABSTRACT Objective Phase 1 clinical trial to determine feasibility, safety, and efficacy of a new advanced cell therapy product for treatment of knee articular cartilage injuries. Methods Three participants with knee focal chondral lesions were included, with no signs of osteoarthritis. Chondrocytes were obtained through knee arthroscopy, cultured in collagen membrane for 3 weeks at the laboratory, subjected to tests to release the cell therapy product, and implanted. All patients underwent a specific 3-month rehabilitation protocol, followed by assessments using functional and imaging scales. The main outcome was the incidence of severe adverse events. Results Three participants were included and completed the 2-year follow-up. There was one severe adverse event, venous thrombosis of distal leg veins, which was no associated with therapy, was treated and left no sequelae. The clinical and radiological scales showed improvement in the three cases. Conclusion The preliminary results, obtained with the described methodology, allow concluding that this product of advanced cell therapy is safe and feasible. ReBEC platform registration number: RBR-6fgy76

https://doi.org/10.31744/einstein_journal/2022ao6819

Management of hypopituitarism: a perspective from the Brazilian Society of Endocrinology and Metabolism
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Garmes, Heraldo Mendes

; Boguszewski, César Luiz

; Miranda, Paulo Augusto Carvalho

; Martins, Manoel Ricardo Alves

; Silva, Silvia Regina Correa da

; Abucham Filho, Julio Zaki

; Musolino, Nina Rosa de Castro

; Vilar, Lucio

; Portari, Luiz Henrique Corrêa

; Gadelha, Mônica Roberto

; Kasuki, Leandro

; Naves, Luciana Ansaneli

; Czepielewski, Mauro Antônio

; Almeida, Tobias Skrebsky de

; Duarte, Felipe Henning Gaia

; Glezer, Andrea

; Bronstein, Marcello Delano

Archives of Endocrinology and Metabolism

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apr 2021, Volume 65 N. 2 Pages 212 - 230

Abstract: En | Text: En | PDF: En

ABSTRACT Hypopituitarism is a disorder characterized by insufficient secretion of one or more pituitary hormones. New etiologies of hypopituitarism have been recently described, including head trauma, cerebral hemorrhage, and drug-induced hypophysitis. The investigation of patients with these new disorders, in addition to advances in diagnosis and treatment of hypopituitarism, has increased the prevalence of this condition. Pituitary hormone deficiencies can induce significant clinical changes with consequent increased morbidity and mortality rates, while hormone replacement based on current guidelines protects these patients. In this review, we will first discuss the different etiologies of hypopituitarism and then address one by one the clinical aspects, diagnostic evaluation, and therapeutic options for deficiencies of TSH, ACTH, gonadotropin, and GH. Finally, we will detail the hormonal interactions that occur during replacement of pituitary hormones.

https://doi.org/10.20945/2359-3997000000335 625 downloads

10.

Effects of Raloxifene Combined with Low-dose Conjugated Estrogen on the Endometrium in Menopausal Women at High Risk for Breast Cancer
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Carneiro, Andrea Lucia Bastos

; Spadella, Ana Paula Curi

; Souza, Fabiola Amaral de

; Alves, Karen Borelli Ferreira

; Araujo-Neto, Joaquim Teodoro de

; Haidar, Mauro Abi

; Dardes, Rita de Cássia de Maio

Clinics

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2021, Volume 76 elocation e2380

Abstract: En | Text: En | PDF: En

OBJECTIVES: To compare the effects of low-dose conjugated estrogen (CE), raloxifene, and the combination thereof on the endometrium of postmenopausal women. METHODS: Postmenopausal women between 45 and 60 years of age, with Gail score≥1.67 and no endometrial disorders, were randomly assigned to receive low-dose CE (0.3 mg), raloxifene (60 mg), or combined therapy for 1 year. Transvaginal ultrasound was performed at baseline and every 3 months; the Kupperman Index was assessed at baseline and every 6 months. Endometrial biopsies were performed if endometrial thickness (ET) was ≥5 mm or if vaginal bleeding occurred. The primary outcome was the occurrence of ET≥5 mm over the one-year period. RESULTS: Seventy-three women were randomly assigned and analyzed on an intent-to-treat basis. Eight, three, and four women in the CE, raloxifene, and combination groups, respectively, exhibited ET≥5 mm. No genital bleeding was reported in the combination group. Endometrial biopsy revealed atrophy or polyps in all groups, with one patient in the CE group exhibiting a proliferative endometrium without atypia. At 6 months, there was a progressive increase in mean ET in the CE group, but not in the other two groups, with statistically significant differences at 6, 9, and 12 months. Mean scores for vasomotor symptoms and Kupperman Index favored the CE and combination groups over raloxifene. CONCLUSION: Combined raloxifene and low-dose CE decreased the severity of menopausal symptoms to a similar extent as CE alone and had similar effects as raloxifene alone on the endometrium.

https://doi.org/10.6061/clinics/2021/e2380 650 downloads

11.

The Mediterranean Sea we want
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Cappelletto, Margherita

; Santoleri, Rosalia

; Evangelista, Lorenza

; Galgani, Francois

; Garcés, Esther

; Giorgetti, Alessandra

; Fava, Fabio

; Herut, Barak

; Hilmi, Karim

; Kholeif, Suzan

; Lorito, Stefano

; Sammari, Cherif

; Lianos, Mónica Campillos

; Celussi, Mauro

; D’Alelio, Domenico

; Francocci, Fedra

; Giorgi, Giordano

; Canu, Donata Melaku

; Organelli, Emanuele

; Pomaro, Angela

; Sannino, Gianmaria

; Segou, Margarita

; Simoncelli, Simona

; Babeyko, Andrey

; Barbanti, Andrea

; Chang-Seng, Denis

; Cardin, Vanessa

; Casotti, Raffaella

; Drago, Aldo

; Asmi, Souha El

; Eparkhina, Dina

; Fichaut, Michèle

; Hema, Tatjiana

; Procaccini, Gabriele

; Santoro, Francesca

; Scoullos, Michael

; Solidoro, Cosimo

; Trincardi, Fabio

; Tunesi, Leonardo

; Umgiesser, Georg

; Zingone, Adriana

; Ballerini, Tosca

; Chaffai, Amel

; Coppini, Giovanni

; Gruber, Sieglinde

; Knezevic, Jelena

; Leone, Gaetano

; Penca, Jerneja

; Pinardi, Nadia

; Petihakis, George

; Rio, Marie-Helen

; Said, Mohamed

; Siokouros, Zacharias

; Srour, Abdellah

; Snoussi, Maria

; Tintoré, Joaquín

; Vassilopoulou, Vassiliki

; Zavatarelli, Marco

Ocean and Coastal Research

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2021, Volume 69 Suppl. 1 elocation e21031

Abstract: En | Text: En | PDF: En

Abstract This paper presents major gaps and challenges for implementing the UN Decade of Ocean Science for Sustainable Development (2021-2030) in the Mediterranean region. The authors make recommendations on the scientific knowledge needs and co-design actions identified during two consultations, part of the Decade preparatory-phase, framing them in the Mediterranean Sea’s unique environmental and socio-economic perspectives. According to the ‘Mediterranean State of the Environment and Development Report 2020’ by the United Nations Environment Programme Mediterranean Action Plan and despite notable progress, the Mediterranean region is not on track to achieve and fully implement the Sustainable Development Goals of Agenda 2030. Key factors are the cumulative effect of multiple human-induced pressures that threaten the ecosystem resources and services in the global change scenario. The basin, identified as a climate change vulnerability hotspot, is exposed to pollution and rising impacts of climate change. This affects mainly the coastal zones, at increasing risk of extreme events and their negative effects of unsustainable management of key economic assets. Transitioning to a sustainable blue economy is the key for the marine environment’s health and the nourishment of future generations. This challenging context, offering the opportunity of enhancing the knowledge to define science-based measures as well as narrowing the gaps between the Northen and Southern shores, calls for a joint (re)action. The paper reviews the state of the art of Mediterranean Sea science knowledge, sets of trends, capacity development needs, specific challenges, and recommendations for each Decade’s societal outcome. In the conclusions, the proposal for a Mediterranean regional programme in the framework of the Ocean Decade is addressed. The core objective relies on integrating and improving the existing ocean-knowledge, Ocean Literacy, and ocean observing capacities building on international cooperation to reach the “Mediterranean Sea that we want”.

https://doi.org/10.1590/2675-2824069.21019mc 2 downloads

12.

Proposal for Gait Analysis Using Fusion of Inertial-Magnetic and Optical Sensors
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Callejas-Cuervo, Mauro

; Vélez-Guerrero, Manuel A.

; Alarcón-Aldana, Andrea C.

Revista EIA

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dec 2020, Volume 17 N. 34 Pages 361 - 371

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Se presenta una propuesta para el desarrollo de un protocolo de medición para el análisis del movimiento de las extremidades inferiores durante la marcha, con el uso de un sistema de medición basado en unidades de procesamiento de movimiento inercial-magnético y un sistema óptico. Inicialmente, se presenta el estado del arte en términos de métodos y herramientas para la captura biomecánica de movimientos, para finalmente explorar los protocolos utilizados en las ciencias de la salud para el análisis de la marcha. La propuesta de medición realizada en este documento utiliza características robustas de la tecnología inercial-magnética y óptica que puede ser usado en el diagnóstico médico. La aplicación de ésta propuesta puede generar herramientas que impactan positivamente en los campos de la salud y la medicina.

Abstract A proposed measurement protocol for the lower limbs movement analysis during walking is presented, with the use of a measurement system based on inertial-magnetic motion processing units and an optical system. Initially, the state of the art in terms of methods and tools for the biomechanical capture of movements is shown, to finally explore the protocols used in the health sciences for the gait analysis. The measurement proposal made in this document uses robust features of inertial-magnetic and optical technology that can be used in medical diagnosis. The application of this proposal can generate tools that have a positive impact in the fields of health and medicine.

https://doi.org/10.24050/reia.v17i34.1472 37 downloads

13.

Literatura e audiovisual em José Mauro de Vasconcelos
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Leão, Andrea Borges

; Farias, Edson

Tempo Social

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aug 2020, Volume 32 N. 2 Pages 123 - 148

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Este artigo abre um debate sobre as condições de circulação e recepção transnacional das obras como fator de diferenciação nas carreiras literarias nacionais. O objetivo central é mostrar de que modo as dinâmicas da tradução funcionam como recursos possíveis para reconhecimento e consagração, considerando escritores posicionados nas margens da produção simbólica nacional. O percurso do escritor José Mauro de Vasconcelos, cuja obra descreve movimentos entre a literatura e o audiovisual a partir de 1950, estabelece relações explicativas de alto rendimento analítico com a problemática da recepção transnacional da produção brasileira. A confluência e a transferência entre cânones nacionais, além de aproximar escalas de observação dos regimes de autoria, vinculam-se à circulação da literatura popular sentimental para além dela mesma.

Abstract This article opens a debate about the transnational circulation and reception conditions of the works as a differential factor in the national literary careers. The main objective is to show in which way the dynamics of translation work as possible resources for recognition and consecration, considering writers positioned on the borders of national symbolic production. The path of the writer José Mauro de Vasconcelos, whose work describes movements between literature and audiovisual from 1950, establishes explanatory relations of high analytical performance with the problematics of the Brazilian production transnational reception. The confluence and the transfer between national canons, aside from approximating the observation scales of the authorship regime, is linked to the sentimental popular literary circulation beyond itself.

https://doi.org/10.11606/0103-2070.ts.2020.168354 1052 downloads

14.

Multimodal HIIT is More Efficient Than Moderate Continuous Training for Management of Body Composition, Lipid Profile and Glucose Metabolism in the Diabetic Elderly
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Louzada-Júnior, Adalberto

; da-Silva, Josimar Mota

; da-Silva, Vernon Furtado

; Castro, Antônio Clodoaldo Melo

; de-Freitas, Rodrigo Eufrásio

; Cavalcante, Joy Braga

; dos-Santos, Kennedy Maia

; Albuquerque, Ana Paula Azevedo

; Brandão, Paula Paraguassú

; Bello, Maria de Nazaré Dias

; Guimarães, Andrea Carmen

; Carvalho, Mauro Cesar Gurgel de Alencar

; Pernambuco, Carlos Soares

; Lima, Eder Benício Ramos

; Coelho, Renato Ramos

; Santos, César Augusto de Souza

; Bezerra, Jani Cleria Pereira

; Dantas, Estélio Henrique Martin

; Romeu-Silva, Paulo Martins

; da-Silva, Carolina Freitas

; Sampaio, Aristeia Nunes

; Valentim-Silva, João Rafael

International Journal of Morphology

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apr 2020, Volume 38 N. 2 Pages 392 - 399

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

SUMMARY: The exercise could play a central role to the fat management and glucose metabolism what can be a critical role in the health status of diabetic people, but the high intense exercise remains with controversial data about their effects. To identify the effect of the multimodal high-intensity interval training on body composition, lipid profile, and glucose metabolism in elderly diabetics. Methods: Elderly diabetic individuals (n = 48) were randomly divided in a Sedentary Control (SC) group, a Moderate-Intensity Continuous Training (MICT) group, and a High-Intensity Interval Training (HIIT) group. MICT and HITT were conducted over 60 days, 3x per week, with 40 minutes of exercise. Blood was collected prior to intervention, at four, and at eight weeks subsequently to assess glucose metabolism and lipid profiles. Body composition was determined before and after the intervention period. To verify the normality Kolmogorov-Smirnov statistical test was performed, followed by student "t" test or two-way ANOVA with Bonferroni’s post hoc test with significance of 5 % the Cohen’s f test to indicate the magnitude of the differences. HIIT significantly lowered cholesterol and triglyceride levels, and significantly lowered blood glucose and glycosylated haemoglobin levels (p<0.05). MICT and HIIT significantly increased levels of high-density lipoprotein, decreased total body mass and body mass index. HIIT resulted in significantly smaller waist circumferences, waist-to-hip ratios, and weight-to-height ratios over 60 days of training. HIIT is more effective than MICT for improving lipid and glycaemic profiles, decreasing body fat, and improving fat distribution elderly diabetics.

RESUMEN: El ejercicio podría desempeñar un papel central en el manejo de la grasa y el metabolismo de la glucosa, lo que puede ser un papel crítico en el estado de salud de las personas diabéticas, pero el ejercicio intenso intenso sigue teniendo datos controvertidos sobre sus efectos. El objetivo del estudio fue identificar el efecto del entrenamiento multimodal de intervalos de alta intensidad sobre la composición corporal, el perfil lipídico y el metabolismo de la glucosa en diabéticos de edad avanzada. Los individuos diabéticos de edad avanzada (n = 48) se dividieron aleatoriamente en un grupo de control sedentario (SC), un grupo de entrenamiento continuo de intensidad moderada (MICT) y un grupo de entrenamiento de intervalos de alta intensidad (HIIT). MICT y HITT se realizaron durante 60 días, 3 veces por semana, con 40 minutos de ejercicio. Se recogió sangre antes de la intervención, a las cuatro y a las ocho semanas posteriormente para evaluar el metabolismo de la glucosa y los perfiles de lípidos. La composición corporal se determinó antes y después del período de intervención. Para verificar la normalidad se realizó la prueba estadística de Kolmogorov-Smirnov, seguida de la prueba "t" de Student o ANOVA de dos vías con la prueba post hoc de Bonferroni con una significancia del 5 % de la prueba f de Cohen, indicando las diferencias. HIIT redujo significativamente los niveles de colesterol y triglicéridos, además de reducir de manera importante los niveles de glucosa en la sangre y la hemoglobina glicosilada (p <0.05). MICT y HIIT aumentaron significativamente los niveles de lipoproteína de alta densidad, disminuyeron la masa corporal total y el índice de masa corporal. HIIT resultó en circunferencias de cintura significativamente más pequeñas, relaciones cintura-cadera y relaciones peso-altura durante 60 días de entrenamiento. HIIT es más efectivo que MICT para mejorar los perfiles de lípidos y glucémicos, disminuir la grasa corporal y mejorar la distribución de grasa en los diabéticos de edad avanzada.

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15.

Characterization of Wireless Data Transmission over Wi-Fi in a Biomechanical Information Processing System
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Callejas-Cuervo Ph.D., Mauro

; Vélez-Guerrero M.Sc., Manuel-Andrés

; Alarcón-Aldana M.Sc., Andrea-Catherine

Revista Facultad de Ingeniería

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mar 2020, Volume 29 N. 54 elocation e10228

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen Este artículo presenta una caracterización de la transmisión inalámbrica de señales biomecánicas en un sistema embebido, donde se utiliza un protocolo TCP en una red de comunicaciones IEEE 802.11 (Wi-Fi). El sistema embebido en estudio, denominado Imocap, permite la recogida, análisis y transmisión de señales biomecánicas en tiempo real para diversas aplicaciones, entre las que destacan el análisis del movimiento de las extremidades inferiores y superiores y la activación de diversos sistemas de control. Para este fin, Imocap está equipado con un módulo transceptor Wi-Fi (ESP8266) y varios periféricos de entrada y salida. El desempeño de la comunicación inalámbrica de Imocap, expuesto en este trabajo, fue analizado a través de diferentes pruebas en condiciones diversas como en interiores, exteriores y en presencia de interferencia, ruido y otras redes inalámbricas. Los diferentes protocolos de prueba realizados dan como resultado que el sistema Imocap: 1) tiene un alcance efectivo máximo de 45,6 m cuando está en modo Access Point; 2) tiene un alcance efectivo máximo de 44,3 m cuando está en modo Station. En interior y en las mismas condiciones, el sistema Imocap: 3) tiene un alcance efectivo máximo de 81,25 m2, ya sea en modo Punto de Acceso o en modo Estación. Los resultados mostraron que la transmisión de información biomecánica a través de Wi-Fi utilizando el protocolo TCP es eficiente y robusta, tanto en interiores como en exteriores, incluso en entornos de interferencia de radiofrecuencia. Se destaca el uso de este protocolo ya que su uso permite que la transmisión de paquetes se realice de forma controlada, permitiendo el manejo y recuperación de errores. De esta manera, es posible llevar a cabo una comunicación inalámbrica eficiente y robusta a través de dispositivos embebidos y portátiles, centrándose principalmente en áreas como la medicina, la telemedicina y la telerehabilitación.

Abstract This paper presents a characterization of the wireless transmission of biomechanical signals in an embedded system, where a TCP protocol is used in an IEEE 802.11 communications network (Wi-Fi). The embedded system under study, called Imocap, allows the collection, analysis and transmission of biomechanical signals in real-time for various applications, among which the analysis of the movement of the lower and upper extremities and the operation of various control systems stand out. To accomplish this, Imocap is equipped with a Wi-Fi transceiver module (ESP8266) and various input and output peripherals. The wireless communication performance of Imocap, exposed in this paper, was analyzed through different tests in miscellaneous conditions like indoors, outdoors and in the presence of interference, noise and other wireless networks. The different test protocols conducted result in the Imocap system: 1) has a maximum effective range of 45.6 m when in Access Point mode; 2) has a maximum effective range of 44.3 m when in Station mode. In indoors and under the same conditions, the Imocap system: 3) has a maximum effective range of 81.25 m2, either Access Point or Station mode. The results showed that the transmission of biomechanical information through Wi-Fi using the TCP protocol is efficient and robust, both indoors and outdoors, even in environments of radio frequency interference. The use of this protocol is emphasized since its use allows the transmission of packages to be carried out in a controlled manner, allowing the error handling and recovery. In this way, it is possible to carry out efficient and robust wireless communication through embedded and portable devices, focusing mainly on areas such as medicine, telemedicine and telerehabilitation.

Resumo Este artigo apresenta uma caracterização da transmissão sem fio de sinais biomecânicos em um sistema embebido, onde utiliza-se um protocolo TCP em uma rede de comunicações IEEE 802.11 (Wi-Fi). O sistema embebido em estudo, denominado Imocap, permite a coleta, análise e transmissão de sinais biomecânicos em tempo real para diversas aplicações, entre as que destacam a análise do movimento das extremidades inferiores e superiores e a ativação de diversos sistemas de controle. Para este fim, Imocap está equipado com um módulo transceptor Wi-Fi (ESP8266) e vários periféricos de entrada e saída. O desempenho da comunicação sem fio de Imocap, exposto neste trabalho, foi analisado através de diferentes provas em condições diversas como em interiores, exteriores e em presença de interferência, ruído e outras redes sem fio. Os diferentes protocolos de prova realizados dão como resultado que o sistema Imocap: 1) tem um alcance efetivo máximo de 45,6 m quando está em modo Access Point; 2) tem um alcance efetivo máximo de 44,3 m quando está em modo Station. Em interior e nas mesmas condições, o sistema Imocap: 3) tem um alcance efetivo máximo de 81,25 m2, já seja em modo Ponto de Acesso ou em modo Estação. Os resultados mostraram que a transmissão de informação biomecânica através de Wi-Fi utilizando o protocolo TCP é eficiente e robusta, tanto em interiores como em exteriores, incluso em ambientes de interferência de radiofrequência. Destaca-se o uso deste protocolo já que seu uso permite que a transmissão de pacotes se realize de forma controlada, permitindo o controle e a recuperação de erros. Desta maneira, é possível levar a cabo uma comunicação sem fio eficiente e robusta através de dispositivos embebidos e portáteis, centrando-se principalmente em áreas como a medicina, a telemedicina e a telereabilitação.

https://doi.org/10.19053/01211129.v29.n54.2020.10228 511 downloads

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