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ABSTRACT Purpose: To develop a simple, subjective, and reliable grading scale for isotretinoin-induced meibography changes. Methods: After analyzing meibography images obtained from systemic isotretinoin users, a grading scale was proposed and named “meibography health score.” The score ranged from 1 to 3, with decreasing gland reflectivity and identifiable margins. A total of 11 medical professionals were asked to grade 10 meibography images obtained from isotretinoin users using the proposed scale and were divided into three groups: (A) ophthalmologists with experience with meibography, (B) ophthalmologists with no experience with meibography, and (C) radiologists. The kappa statistic was determined to test interrater reliability. Results: The overall kappa was approximately 0.64. The kappa scores for Groups A, B, and C were 0.78, 0.59, and 0.90, respectively. Grade 2 had the lowest kappa scores (0.62, 0.35, and 0.82 for A, B, and C, respectively) and grade 3 the highest (0.78, 0.90, and 1.0 for A, B and C, respectively). Furthermore, Group C had the highest kappa scores and Group B the lowest. Conclusion: The meibography health score exhibited good interrater reliability, particularly in severe cases. Purpose simple subjective isotretinoininduced induced changes Methods score. margins groups (A (B (C radiologists reliability Results 064 0 64 0.64 078 78 0.78 059 59 0.59 090 90 0.90 respectively 0.62, 062 62 (0.62 035 35 0.35 082 82 0.8 (0.78 1. . Furthermore Conclusion cases 06 6 0.6 07 7 0.7 05 5 0.5 09 9 0.9 0.62 (0.6 03 0.3 08 8 0. (0.7 (0. (0 (

https://doi.org/10.5935/0004-2749.2023-0150

Growth and bioactive compounds of baby-leaf chicory on colored cultivation benches with different wavelengths
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Araújo, Tassila Aparecida do Nascimento de

; Costa, Edilson

; Dantas, Thaise

; Binotti, Flávio Ferreira da Silva

; Vendruscolo, Eduardo Pradi

; Vieira, Gustavo Haralampidou da Costa

; Ribeiro, Fernanda Cristina Silva

; Lima, Sandro Marcio

; Andrade, Luis Humberto da Cunha

Chilean journal of agricultural research

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oct 2024, Volume 84 N. 5 Pages 653 - 662

Abstract: En | Text: En | PDF: En

ABSTRACT Care for human well-being and health requires the consumption of healthy foods, and therefore, the “baby-leaf” gains increased space in the market as they have higher concentrations of bioactive compounds. The present study aimed to evaluate the growth and bioactive compounds of baby-leaf chicory (Cichorium intybus L.) according to the color of cultivation benches with different wavelengths. The experiment was conducted in a non-acclimatized greenhouse, covered with low density polyethylene film with an aluminized screen of 50% shading under the film and 50% shading screens on the sides. In a completely randomized design, five types of benches were evaluated without and with bright reflective colored materials: Control bench without reflective material, a bench with reflective bright white laminate, reflective bright dark red laminate, reflective bright dark blue laminate, and reflective bright yellow laminate. The bright white and yellow laminates amplified the most photosynthetically active radiation. All the laminates enhanced yield of baby-leaf chicory plants, where white, yellow, red, and dark blue enhanced the fresh matter by 102.6%, 50.2%, 60.6%, and 37.4% compared to the control, respectively. The bright dark blue laminates enhanced the bioactive compounds of baby-leaf chicory plants. The bright dark blue laminate enhanced the carotenoid production of baby-leaf chicory plants by 11.0%. The use of colored laminates was effective in the cultivation of baby-leaf chicory, both in terms of yield and quality, with significant increases in fresh matter and bioactive compounds. To provide baby-leaf chicory with higher bioactive content with antioxidant effect (carotenoids) the use of dark blue laminates is necessary; however, if the objective is greater shoot DM it will be white laminates.

https://doi.org/10.4067/s0718-58392024000500653

[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio Simões, Marcus V. Correia, Edileide de Barros Marcondes-Braga, Fabiana G. Coelho-Filho, Otavio Rizzi Mesquita, Cláudio Tinoco Mathias-Junior, Wilson Rochitte, Carlos Eduardo Ramires, Felix José Alvarez Alves, Silvia Marinho Martins Montera, Marcelo Westerlund Lopes, Renato Delascio Oliveira-Junior, Mucio Tavares Scolari, Fernando L. Avila, Walkiria Samuel Canesin, Manoel Fernandes Bacal, Fernando Bocchi, Edimar Alcides Moura, Lídia Ana Zytynski Saad, Eduardo Benchimol Scanavacca, Mauricio I. Valdigem, Bruno Pereira Cano , Manuel Nicolas Abizaid , Alexandre Ribeiro, Henrique Barbosa Lemos-Neto, Pedro Alves Ribeiro, Gustavo Calado de Aguiar Jatene, Fabio Biscegli Dias, Ricardo Ribeiro Beck-da-Silva, Luis Rohde, Luis Eduardo P. Bittencourt, Marcelo Imbroinise Pereira, Alexandre Krieger, José Eduardo Villacorta, Humberto Martins, Wolney de Andrade Figueiredo-Neto, José Albuquerque de Cardoso , Juliano Novaes Pastore, Carlos Alberto Jatene, Ieda Biscegli Tanaka, Ana Cristina Sayuri Hotta, Viviane Tiemi Romano, Minna Moreira Dias Albuquerque, Denilson Campos de Mourilhe-Rocha, Ricardo Hajjar, Ludhmila Abrahão Brito, Fabio Sandoli de Caramelli , Bruno Calderaro, Daniela Farsky, Pedro Silvio Colafranceschi , Alexandre Siciliano Pinto, Ibraim Masciarelli Vieira , Marcelo Luiz Campos Danzmann, Luiz Claudio Barberato , Silvio Henrique Mady, Charles Martinelli-Filho, Martino Torbey , Ana Flavia Malheiros Schwartzmann, Pedro Vellosa Macedo, Ariane Vieira Scarlatelli Ferreira , Silvia Moreira Ayub Schmidt, Andre Melo , Marcelo Dantas Tavares de Lima-Filho, Moysés Oliveira Sposito, Andrei C. Brito, Flavio de Souza Biolo, Andreia Madrini-Junior, Vagner Rizk, Stéphanie Itala Mesquita, Evandro Tinoco

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Publication date: 2024-04-08

Abstract: Pt Es En

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

https://doi.org/10.1590/SciELOPreprints.8394

Clinical evaluation of allogeneic adipose tissue-derived stem cells for the treatment of osteoarthritis secondary to hip dysplasia in dogs tissuederived tissue derived
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Siqueira, Jackson de Oliveira

; Barros, Michele Andrade de

; Martins, João Flávio Panattoni

; Guerrera, Mariane Ubrik

; Leite, Caroline da Silva

; Feitosa, Matheus Cândido

; Morais, Bruna Pereira de

; Soares, Anísio Francisco

; Teixeira, Marcelo Weinstein

Ciência Rural

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2024, Volume 54 N. 1 elocation e20220658

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo deste estudo foi avaliar a eficácia clínica da aplicação intra-articular de células-tronco mesenquimais alógenas derivadas do tecido adiposo (AD-CTM) no tratamento de cães portadores de osteoartrite secundária a displasia do coxofemoral (DCF). Doze cães de ambos os sexos, diferentes raças, idades e peso, portadores de graus variados de DCF comprovada em radiografia e livres de quaisquer outras alterações clínicas ou ortopédicas, foram utilizados no estudo. Todos os cães foram submetidos a avaliação ortopédica nos dias 0, 30, 60 e 90 após aplicação de AD-CTM na dose de 2 x 106. Além disso, os tutores preencheram a um questionário, baseado no Índice de dor crônica de Helsinque (IDCH) nos mesmos intervalos. Em comparação com o dia 0, observou-se melhora significativa na avalição em locomoção e físico-ortopédica assim como na avaliação dos tutores pelo IDCH ao longo dos 90 dias. Os resultados permitem inferir que as AD-CTM alógenas contribuíram significativamente para a redução dos sinais clínicos comumente associados a DCF durante o período de estudo. Entretanto, há necessidade de estudos de longo prazo para melhor determinação de protocolos terapêuticos baseados no uso de AD-CTM na rotina clínica. RESUMO intraarticular intra articular célulastronco células tronco ADCTM AD CTM (AD-CTM DCF. . (DCF) sexos raças peso ortopédicas 0 30 6 9 106 disso questionário (IDCH intervalos observouse observou se físicoortopédica físico Entretanto (DCF 3 10 1

ABSTRACT: This study assessed the efficacy of an intra-articular injection of allogeneic adipose tissue-derived from mesenchymal stem cells (AD-MSCs) for the treatment of hip dysplasia in dogs. The study group included 12 otherwise healthy dogs of different breeds, ages, weights, and degrees of hip dysplasia diagnosed using radiography. An orthopedic assessment was performed on all dogs before and at 30, 60, and 90 days after infusion of AD-MSCs(2 × 106cells). On the same days, each dog’s owner answered a questionnaire based on theHelsinkiChronic Pain Index. The data were converted to ordinal data based on the score for each variable, and the Friedman test for multiple comparisons was used to verify the results. Compared with the corresponding values on day 0, orthopedic and gait assessments and owners’ reported pain indexes improved over the 90-day observation period. These results suggested that treatment with allogeneic AD-MSCs significantly reduced the clinical signs associated with hip dysplasia during the study period. However, long-term studies are needed to determine the optimal therapeutic protocol for routine clinical use of AD-MSCs in hip dysplasia. ABSTRACT intraarticular intra articular tissuederived tissue derived ADMSCs AD MSCs (AD-MSCs 1 breeds ages weights radiography 30 60 9 ADMSCs2 2 AD-MSCs( 106cells. 106cells . 106cells) dog s Index variable 0 owners 90day period However longterm long term 3 6

https://doi.org/10.1590/0103-8478cr20220658

Lipectomia como alternativa de superficialização de fístula arteriovenosa autóloga em pacientes obesos: a experiência de um centro de referência na Amazônia obesos
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Reis, José Maciel Caldas dos

; Ribeiro, Flávio Roberto Cavalleiro de Macêdo

; Melo, Glauco dos Santos

; Reale Neto, Humberto Balbi

; Andrade, Mariseth Carvalho de

Jornal Vascular Brasileiro

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2024, Volume 23 elocation e20230054

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Contexto O acesso vascular preferencial para hemodiálise é a fístula arteriovenosa nativa, pois oferece melhores resultados em curto e longo prazo, proporciona menor morbimortalidade e traz vantagens adicionais em relação aos cateteres venosos centrais ou enxertos arteriovenosos. No entanto, a obesidade pode oferecer um desafio adicional proporcionado pela barreira de tecido celular subcutâneo que recobre a superfície da veia a ser puncionada. Objetivos Demonstrar a experiência do serviço com a lipectomia em acessos autólogos em pacientes obesos. Métodos Foram revisados pacientes consecutivos submetidos à lipectomia por impossibilidade ou dificuldade na punção da FAV, motivada pela acentuada profundidade da veia cefálica no antebraço ou braço. Resultados Vinte e dois pacientes foram revisados (15 homens e 7 mulheres), com índice de massa corporal médio de 34 kg/m2 (variação de 28 a 40 kg/m2). A idade média foi de 58,4 anos. O tempo médio entre a confecção do acesso e a lipectomia foi de 45,1 dias, e o tempo da intervenção até a liberação para uso nas sessões de hemodiálise oscilou de 21 a 42 dias, com média de 30,9 dias. A profundidade média pré-operatória da veia cefálica no membro foi de 7,9 mm (variação de 7,0 a 10,0 mm). Isso foi reduzido para uma profundidade média de 4,7 mm (faixa de 3,0 a 6,0 mm) (P = 0,01). O período médio de seguimento dos pacientes foi de 13,2 meses. Houve perda de seguimento em quatro pacientes e quatro óbitos no período não relacionados ao acesso vascular. Conclusões A obesidade não deve ser um fator limitante para a criação de uma FAV nativa, pois a lipectomia é uma alternativa relativamente simples de superficialização, que permite a funcionalidade de fístulas arteriovenosas nativas e profundas em obesos. nativa prazo arteriovenosos entanto puncionada obesos braço 15 (1 mulheres, mulheres , mulheres) 3 kgm2 kgm kg m2 m kg/m variação 2 4 kg/m2. . kg/m2) 584 58 58, anos 451 45 1 45, dias 309 30 9 30, préoperatória pré operatória 79 7, 70 0 100 10 10, mm. 47 4, faixa 3, 60 6 6, P 0,01. 001 0,01 01 0,01) 132 13 13, meses superficialização ( 5 00 0,0 0,

Abstract Background The preferred vascular access for hemodialysis is a native arteriovenous fistula (AVF) because it offers the best results in the short and long terms, lower morbidity and mortality, and has additional advantages in relation to central venous catheters or arteriovenous grafts. However, obesity can present an additional challenge because of the barrier of subcutaneous cellular tissue covering the surface of the vein to be punctured. Objectives The authors review their experience with excision of subcutaneous tissue (lipectomy) overlying upper arm cephalic vein arteriovenous fistulas in obese patients. Methods Consecutive vascular access patients undergoing lipectomy for cannulation with difficult access because of vein depth were reviewed. Cephalic vein depth was measured by ultrasound in all cases. Results Twenty-two patients were reviewed (15 men and 7 women), with a mean body mass index of 34.0 kg/m2 (range: 28-40 kg/m2). Mean age was 58.4 years. The mean preoperative vein depth of 7.9 mm (range: 7.0-10.0 mm) was reduced to 4.7 mm (range: 3.0-6.0 mm) (P 0.01). The mean follow-up period for patients was 13.2 months. Four patients were lost to follow-up and four died during the period due to causes unrelated to vascular access. Conclusions Obesity should not be a limiting factor to creation of a native AVF, since lipectomy is a relatively simple option for superficialization, enabling functioning native and deep arteriovenous fistulas in obese patients. AVF (AVF terms mortality grafts However punctured (lipectomy cases Twentytwo Twenty two 15 (1 women, women , women) 340 34 0 34. kgm2 kgm kg m2 m kg/m range (range 2840 28 40 28-4 kg/m2. . kg/m2) 584 58 4 58. years 79 9 7. 7.010.0 70100 7.0 10.0 10 7.0-10. 47 4. 3.06.0 3060 3.0 6.0 3 6 3.0-6. P 0.01. 001 0.01 01 0.01) followup follow up 132 13 2 13. months superficialization 1 ( 284 28- 5 010 7.010. 7010 70 100 10. 7.0-10 06 3.06. 306 30 3. 60 6. 3.0-6 00 0.0 7.010 701 7.0-1 3.06 3.0- 0. 7.01 7.0-

https://doi.org/10.1590/1677-5449.202300541

Leaf gas exchange and water relations in two assai cultivars submitted to water-deficit waterdeficit deficit
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Navegantes, Patricia Cardoso Andrade

; Lopes Filho, Wagner Romulo Lima

; Rodrigues, Flávio Henrique Santos

; Monteiro, Gabriel Gustavo Tavares Nunes

; Chaves, Rosane Patrícia Ferreira

; Oliveira Neto, Candido Ferreira

; Cunha, Roberto Lisboa

; Pinheiro, Hugo Alves

Revista Brasileira de Fruticultura

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2024, Volume 46 elocation e-716

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo As cultivares de açaí (Euterpe oleracea Mart.) BRS-Pará (BRS-PA) e BRS-Pai d’Égua (BRS-PDE) foram selecionadas para cultivo em regiões de terra firme da Amazônia. Como essas cultivares foram desenvolvidas a partir de diferentesprogenitores,nós postulamos que essas cultivares podem diferir na tolerância ao déficithídrico. Para testar essa hipótese, plantas de ambas os cultivares foram avaliadas em condiçõesadequadas de irrigação (controle) e déficit hídrico (potencial hídrico foliar naantemanhã de – 2,33MPa). Em relação ao controle, o déficit hídrico reduziu a taxa de assimilaçãolíquida de CO2(A) e a transpiração, em 82%, e 86% em ambas as cultivares, enquanto acondutância estomática(gs) foi reduzida em 93% e 87%, nas plantas estressadas de BRS-PDE e BRS-PA. O déficit hídrico aumentou a eficiência instantânea do uso da água em 43%, em ambas as cultivares,enquanto a eficiência intrínseca do uso da água (A/gs) aumentou 193% na BRS-PDE e 33% na BRS-PA. O déficit hídrico induziu o aumento de 44% na prolina foliare um decréscimo de 27% nos carboidratos solúveis totais, enquanto a sacarose foliar diminuiu53% na BRS-PA e 16% na BRS-PDE, em relação ao controle. O conteúdo relativo de águanas plantas estressadas de ambas as cultivares diminuiu em 8,5% em relação ao controle. Emconclusão, o controle da abertura estomática mais eficiente e a maior A/gs, na BRS-PDE,indicam que esta cultivar respondeu melhor ao déficit hídrico que a BRS-PA. Euterpe Mart. Mart BRSPará BRS Pará BRSPA PA (BRS-PA BRSPai Pai dÉgua d Égua BRSPDE PDE (BRS-PDE Amazônia diferentesprogenitoresnós diferentesprogenitores nós déficithídrico hipótese (controle potencial 2,33MPa. 233MPa MPa 2,33MPa . 2 33MPa 2,33MPa) CO2A COA CO2 A CO CO2(A transpiração 82 82% 86 estomáticags gs estomática(gs 93 87 87% BRSPA. PA. 43 43% cultivaresenquanto A/gs Ags (A/gs 193 33 44 27 totais diminuiu53 16 BRSPDE, PDE, 85 8 5 8,5 Emconclusão BRSPDE,indicam BRSPDEindicam PDE,indicam indicam 9 4 19 3 diminuiu5 1 8, PDEindicam

Abstract: Assai (Euterpe oleracea Mart.) cultivars BRS-Pará (BRS-PA) and BRS-Pai d’Égua (BRS-PDE) were selected for cultivation in upland regions of the Amazon. Given these cultivars were developed from different progenitors, we postulated that they differ regarding water-deficit tolerance. To test this hypothesis, plants of both cultivars were evaluated under well-watered (control) and water-deficit conditions (pre-dawn leaf water potential of – 2.33 MPa). Relative to control, the water-deficit decreased net CO2 assimilation rate (A) and transpiration by 82% and 86% in both cultivars, while the stomatal conductance (gs) was reduced by 93% and 87% in stressed plants of BRS-PDE and BRS-PA. The water-deficit improved instantaneous water-use efficiency by 43% in both cultivars, while intrinsic water-use efficiency (A/gs) increased by 193% and 33% in BRS-PDE and BRS-PA. The water-deficit induced 44% increase in foliar proline and 27% decrease in soluble carbohydrates in both cultivars, while foliar sucrose decreased by 53% in BRS-PA and 16% in BRS-PDE in relation to control. The relative water content in stressed plants of both cultivars was decreased by 8.5% in relation to control. In conclusion, the more efficient stomatal opening control and higher A/gs in BRS-PDE indicate this cultivar better copes with drought than BRS-PA. Abstract Euterpe Mart. Mart BRSPará BRS Pará BRSPA PA (BRS-PA BRSPai Pai dÉgua d Égua BRSPDE PDE (BRS-PDE Amazon progenitors waterdeficit deficit tolerance hypothesis wellwatered well watered (control predawn pre dawn 233 2 33 2.3 MPa. MPa . MPa) CO A (A 82 86 gs (gs 93 87 BRSPA. PA. wateruse use 43 Ags (A/gs 193 44 27 53 16 85 8 5 8.5 conclusion 23 3 2. 9 4 19 1 8.

https://doi.org/10.1590/0100-29452024716

Diretriz sobre Diagnóstico e Tratamento da Cardiomiopatia Hipertrófica – 2024 202 20 2
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Fernandes, Fabio

; Simões, Marcus V.

; Correia, Edileide de Barros

; Marcondes-Braga, Fabiana Goulart

; Coelho-Filho, Otavio Rizzi

; Mesquita, Cláudio Tinoco

; Mathias Junior, Wilson

; Antunes, Murillo de Oliveira

; Arteaga-Fernández, Edmundo

; Rochitte, Carlos Eduardo

; Ramires, Felix José Alvarez

; Alves, Silvia Marinho Martins

; Montera, Marcelo Westerlund

; Lopes, Renato Delascio

; Oliveira Junior, Mucio Tavares de

; Scolari, Fernando Luis

; Avila, Walkiria Samuel

; Canesin, Manoel Fernandes

; Bocchi, Edimar Alcides

; Bacal, Fernando

; Moura, Lidia Zytynski

; Saad, Eduardo Benchimol

; Scanavacca, Mauricio Ibrahim

; Valdigem, Bruno Pereira

; Cano, Manuel Nicolas

; Abizaid, Alexandre Antonio Cunha

; Ribeiro, Henrique Barbosa

; Lemos Neto, Pedro Alves

; Ribeiro, Gustavo Calado de Aguiar

; Jatene, Fabio Biscegli

; Dias, Ricardo Ribeiro

; Beck-da-Silva, Luis

; Rohde, Luis Eduardo Paim

; Bittencourt, Marcelo Imbroinise

; Pereira, Alexandre da Costa

; Krieger, José Eduardo

; Villacorta Junior, Humberto

; Martins, Wolney de Andrade

; Figueiredo Neto, José Albuquerque de

; Cardoso, Juliano Novaes

; Pastore, Carlos Alberto

; Jatene, Ieda Biscegli

; Tanaka, Ana Cristina Sayuri

; Hotta, Viviane Tiemi

; Romano, Minna Moreira Dias

; Albuquerque, Denilson Campos de

; Mourilhe-Rocha, Ricardo

; Hajjar, Ludhmila Abrahão

; Brito Junior, Fabio Sandoli de

; Caramelli, Bruno

; Calderaro, Daniela

; Farsky, Pedro Silvio

; Colafranceschi, Alexandre Siciliano

; Pinto, Ibraim Masciarelli Francisco

; Vieira, Marcelo Luiz Campos

; Danzmann, Luiz Claudio

; Barberato, Silvio Henrique

; Mady, Charles

; Martinelli Filho, Martino

; Torbey, Ana Flavia Malheiros

; Schwartzmann, Pedro Vellosa

; Macedo, Ariane Vieira Scarlatelli

; Ferreira, Silvia Moreira Ayub

; Schmidt, Andre

; Melo, Marcelo Dantas Tavares de

; Lima Filho, Moysés Oliveira

; Sposito, Andrei C.

; Brito, Flávio de Souza

; Biolo, Andreia

; Madrini Junior, Vagner

; Rizk, Stephanie Itala

; Mesquita, Evandro Tinoco

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 7 elocation e202400415

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.36660/abc.20240415

Volatile and phenolic compounds in white wines produced at Campanha Gaúcha, Brazil Gaúcha
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Kaltbach, Suélen Braga de Andrade

; Lemos, Pedro Luís Panisson Kaltbach

; Costa, Vagner Brasil

; Herter, Flávio Gilberto

; Brunetto, Gustavo

; Santos, Cristina Maria Gonçalves dos

; Couto, José António

Ciência Rural

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2024, Volume 54 N. 10 elocation e20220596

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: A região da Campanha Gaúcha recebeu recentemente, em 2020, a Indicação de Procedência ‘IP Campanha Gaúcha’ para vinhos e espumantes. Dados científicos e pesquisas desenvolvidas nas últimas décadas puderam fornecer as informações necessárias para esta primeira caracterização da área. No entanto, faltam dados detalhados sobre a composição dos vinhos da Campanha Gaúcha. Neste estudo, vinhos de cinco variedades de uva branca (Riesling, Gewürztraminer, Semillon, Sauvignon Blanc e Chardonnay), produzidos na Campanha Gaúcha na safra 2018, foram coletados diretamente da vinícola e encaminhados para análises de vários compostos voláteis e fenólicos. Essa safra foi classificada entre as melhores das três décadas anteriores para esta região. Os resultados, oriundos dessa excelente safra, demonstram o potencial qualitativo da região para as castas abrangidas por este estudo. São registros importantes para a construção e ampliação de bancos de dados para pesquisas futuras e também podem fornecer embasamento científico para definição mais detalhada das diferenças e semelhanças intra e inter-regionais quanto às características dos vinhos da Campanha Gaúcha. RESUMO recentemente 2020 IP espumantes área entanto estudo Riesling, Riesling (Riesling Gewürztraminer Semillon Chardonnay, Chardonnay , Chardonnay) 2018 fenólicos resultados interregionais inter regionais 202 201 20 2

ABSTRACT: The Campanha Gaúcha region has recently (2020) received an Indication of Provenance (‘IP Campanha Gaúcha’) for wines and sparkling wines. Scientific data and research developed during the last decades could provide the necessary information for this first characterization of the area. Nevertheless, there is a lack of detailed data about the composition of Campanha Gaúcha wines. In this study, five Campanha Gaúcha white wines of different grape varieties (Riesling, Gewürztraminer, Semillon, Sauvignon Blanc and Chardonnay) produced in the 2018 vintage were collected directly from the winery and followed analyses of several volatile and phenolic compounds. The 2018 vintage was rated among the best of the 3 preceding decades for this region. The results, originated from this excellent vintage, demonstrate the qualitative potential of the region for the wines elaborated with the grape varieties covered by this study. They are important records for the construction and enlargement of databases for future research and can also provide further scientific basis for more detailed definition of intra-regional and inter-regional differences and similarities regarding the characteristics of Campanha Gaúcha wines. ABSTRACT 2020 (2020 ‘IP IP Gaúcha’ area Nevertheless study Riesling, Riesling (Riesling Gewürztraminer Semillon Chardonnay 201 compounds results intraregional intra regional interregional inter 202 (202 20 (20 2 (2 (

https://doi.org/10.1590/0103-8478cr20220596

Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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; Valim, Michel P.

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; Percequillo, Alexandre R.

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2024, Volume 41 elocation e24005

Abstract: En | Text: En | PDF: En

ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7

https://doi.org/10.1590/s1984-4689.v41.e24005

10.

Floods in southern Brazil: the urgent need for mental health support in the context of climatic disasters Brazil
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Roza, Thiago Henrique

; Prates-Baldez, Daniel

; Noal, Debora da Silva

; Schmidt, Beatriz

; Weintraub, Ana Cecilia Andrade de Moraes

; Quagliato, Laiana Azevedo

; Nardi, Antonio Egídio

; Kapczinski, Flavio

Brazilian Journal of Psychiatry

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2024, Volume 46 elocation e20243845

Abstract: En | Text: En | PDF: En

https://doi.org/10.47626/1516-4446-2024-3845

11.

Differentiating Two Species of ‘Mother-of-Thousands’: Kalanchoe daigremontiana and Kalanchoe x houghtonii ‘MotherofThousands MotherofThousands ‘Mother Thousands Mother ‘Mother-of-Thousands’ ‘Mother-of-Thousands
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Andrade, Evelyn Assis de

; Machinski, Isadora

; Almeida, Valter Paes de

; Perera, Wilmer Hervet

; Williamson, Robert Thomas

; Strangman, Wendy Karen

; Manfron, Jane

; Beltrame, Flávio Luís

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24240333

Abstract: En | Text: En | PDF: En

Abstract The widespread medicinal use of Kalanchoe daigremontiana and Kalanchoe × houghtonii, both popularly known as “mother-of-thousands”, often leads to their interchangeable use in folk medicine despite their distinct species status. This research aims to delineate the histochemical, chemical, and biological characteristics of these two Kalanchoe species to aid in their accurate identification. Through a comprehensive evaluation of histochemical markers (reaction patterns in hypodermis), alongside in vitro assessments (correlation of antioxidant activities and phenolic content), and metabolomic profiles (using HPTLC and UPLC-MS/MSE), this study has identified significant differences between K. daigremontiana and K. × houghtonii. The findings reveal distinct variations in all evaluated parameters, underscoring the importance of proper species identification to ensure the safety and efficacy of their medicinal use. These results contribute valuable insights into the phytochemical and pharmacological bases for the traditional uses of these plants and highlight the need for distinguishing between species to avoid potential therapeutic inefficacies or adverse effects in folk medicine practices. houghtonii motherofthousands, motherofthousands mother thousands , “mother-of-thousands” status chemical reaction hypodermis, hypodermis hypodermis) correlation content, content content) using UPLCMS/MSE, UPLCMSMSE UPLC MS/MSE MS MSE UPLC-MS/MSE) K parameters practices “mother-of-thousands UPLCMS UPLCMS/MSE MSMSE UPLC-MS/MSE

https://doi.org/10.1590/1678-4324-2024240333

12.

Uncovering the knowledge about systemic amyloidosis relevant to the rheumatologists
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Pereira, Ivanio Alves

; Rosa Neto, Nilton Salles

; Nascimento, Renan Rodrigues Neves Ribeiro do

; Freire, Eutilia Andrade Medeiros

; Neves, Fabricio de Souza

; Bica, Blanca Elena Rios Gomes

; Pinheiro, Frederico Augusto Gurgel

; Perazzio, Sandro Félix

; Cordeiro, Rafael Alves

; Giardini, Henrique Ayres Mayrink

; Azevedo, Valderilio Feijo

; Sztajnbok, Flavio Roberto

Advances in Rheumatology

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2024, Volume 64 elocation 71

Abstract: En | Text: En | PDF: En

Abstract Amyloidosis is a localized or systemic disease caused by deposition of proteins in the extracellular space of various organs and tissues. As part of the disease, proteins that were originally soluble misfold and acquire a fibrillar conformation that renders them insoluble and resistant to proteolysis. Systemic amyloidosis is a rare, often underdiagnosed condition. In recent years, the incidence of newly diagnosed cases of amyloidosis has been increasing in association with the aging of the population and greater access to diagnostic tests. From a clinical perspective, systemic amyloidosis is frequently associated with involvement of the kidneys (causing nephrotic syndrome), heart (cardiac failure and arrhythmia), and peripheral nervous system (sensorimotor polyneuropathy and autonomic dysfunction). This condition is important to the rheumatologist for several reasons, such as its systemic involvement that mimics autoimmune rheumatic diseases, its musculoskeletal manifestations, which when recognized can allow the diagnosis of amyloidosis, and also because reactive or secondary AA amyloidosis is a complication of rheumatic inflammatory diseases. The treatment of amyloidosis depends on the type of amyloid protein involved. Early recognition of this rare disease is fundamental for improved clinical outcomes. tissues proteolysis years tests perspective causing syndrome, syndrome , syndrome) cardiac arrhythmia, arrhythmia arrhythmia) sensorimotor dysfunction. dysfunction . dysfunction) reasons diseases manifestations involved outcomes

https://doi.org/10.1186/s42358-024-00399-3

13.

Rare diseases: What rheumatologists need to know? diseases know
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Nascimento, Renan Rodrigues Neves Ribeiro do

; Piotto, Daniela Gerent Petry

; Freire, Eutilia Andrade Medeiros

; Neves, Fabricio de Souza

; Sztajnbok, Flavio Roberto

; Bica, Blanca Elena Rios Gomes

; Pinheiro, Frederico Augusto Gurgel

; Kozu, Katia Tomie

; Pereira, Ivanio Alves

; Azevedo, Valderilio Feijo

; Cordeiro, Rafael Alves

; Giardini, Henrique Ayres Mayrink

; Franco, Marco Túlio Muniz

; Carvalho, Margarida de Fátima Fernandes

; Rosa-Neto, Nilton Salles

; Perazzio, Sandro Félix

Advances in Rheumatology

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2024, Volume 64 elocation 74

Abstract: En | Text: En | PDF: En

Abstract Although the terms "rare diseases" (RD) and "orphan diseases" (OD) are often used interchangeably, specific nuances in definitions should be noted to avoid misconception. RD are characterized by a low prevalence within the population, whereas OD are those inadequately recognized or even neglected by the medical community and drug companies. Despite their rarity, as our ability on discovering novel clinical phenotypes and improving diagnostic tools expand, RD will continue posing a real challenge for rheumatologists. Over the last decade, there has been a growing interest on elucidating mechanisms of rare autoimmune and autoinflammatory rheumatic diseases, allowing a better understanding of the role played by immune dysregulation on granulomatous, histiocytic, and hypereosinophilic disorders, just to name a few. This initiative enabled the rise of innovative targeted therapies for rheumatic RD. In this review, we explore the state-of-the art of rare RD and the critical role played by rheumatologists in healthcare. We also describe the challenges rheumatologists may face in the coming decades. diseases (RD orphan (OD interchangeably misconception population companies rarity expand decade granulomatous histiocytic disorders few review stateofthe state healthcare decades

https://doi.org/10.1186/s42358-024-00407-6

14.

Selection and genetic dissimilarity in S2 families of guava through seed attributes S
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Maitan, Mariana Quintas

; Viana, Alexandre Pio

; Vieira, Henrique Duarte

; Santos, Eileen Azevedo

; Silva, Flávio Wirlan Andrade da

Revista Ceres

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aug 2023, Volume 70 N. 4 Pages 73 - 81

Abstract: En | Text: En | PDF: En

ABSTRACT This study was developed to carry out selection, estimate genetic parameters and predict individual genetic values of 55 genotypes from S2 families as well as estimate genetic dissimilarity based on physiological seed attributes. All S2 genotypes evaluated were obtained from self-pollination of S1 genotypes from the guava breeding program. The experiment was laid out in blocks with 55 S2 genotypes and four blocks. Genetic parameters were estimated and the best genotypes were selected based on the genetic value, using the statistical method of mixed models. In addition, genetic divergence was estimated based on the mean Euclidean distance. Although heritability values were considered medium to high magnitude for germination (0.22) and germination speed index (0.35), genetic gains were obtained for all traits. Based on the evaluation of individual BLUPs, the S2 genotypes that contributed to most of the evaluated traits were: 5, 31, 85, 214, 369, 393, 398, 442, 443, 444, 449 and 529, suggesting potential to generate vigorous. Through genetic dissimilarity, it was possible to verify the formation of five distinct groups. Therefore, the selection of divergent genotypes with high average for germination is recommended for the advancement of generation in the guava breeding plant. 5 S attributes selfpollination self pollination program value models addition distance 0.22 022 0 22 (0.22 0.35, 035 0.35 , 35 (0.35) BLUPs 31 85 214 369 393 398 442 443 444 44 529 vigorous groups Therefore plant 0.2 02 2 (0.2 03 0.3 3 (0.35 8 21 36 39 4 52 0. (0. (0.3 (0 (

https://doi.org/10.1590/0034-737x202370040010

15.

Teorização sobre os limites à inserção da saúde bucal na Estratégia Saúde da Família
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Pinheiro, Elisa Lopes

; Vasconcelos, Mara

; Gomes, Viviane Elisângela

; Mattos, Flávio de Freitas

; Andrade, Caroline Pereira Sutani

; Amaral, João Henrique Lara

Ciência & Saúde Coletiva

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apr 2023, Volume 28 N. 4 Pages 1139 - 1150

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Este estudo objetivou construir teorização a partir da concepção de atores sociais acerca das razões da não inserção da atenção à saúde bucal na Estratégia de Saúde da Família (ESF) no município de Juiz de Fora, Minas Gerais. Trata-se de um estudo qualitativo, fundamentado no referencial teórico construído com base na Política Nacional de Saúde Bucal e metodológico na Teoria Fundamentada nos Dados (TFD). Foram realizadas 11 entrevistas intensivas com atores sociais da gestão, do controle social e cirurgiões-dentistas do serviço público do município. Os dados foram categorizados segundo a TFD e a partir do processo de análise dos dados, construiu-se a teorização do estudo e obteve-se como categoria central “Consequência de uma concepção hegemônica doença-centrada da saúde para o modelo de atenção à saúde bucal”. A concepção de saúde dos atores sociais do município contribuiu para a não inserção da atenção à saúde bucal na ESF. A teorização permitiu a identificação da origem das condições do fenômeno estudado e poderá contribuir para tomada de decisões dos atores sociais em futuras ações políticas. ESF (ESF Fora Gerais Tratase Trata se qualitativo TFD. . (TFD) 1 gestão cirurgiõesdentistas cirurgiões dentistas construiuse construiu obtevese obteve Consequência doençacentrada doença centrada bucal. bucal” políticas (TFD

Abstract This study aimed to theorize, by means of social actors’ conception, about the reasons for the non-inclusion of oral health in the Family Health Strategy (FHS) in the city of Juiz de Fora, Minas Gerais, Brazil. This is a qualitative, exploratory, descriptive, and analytical study based on the grounded theory methodology and the National Oral Health Policy. Eleven interviews were performed with public managers, delegates who participate in the municipal health council, and dental surgeons who belong to the public health service. The theorization of the study was created through the data analysis process, which resulted in “a consequence of the dominant disease-centered oral health care model” as the main category. Data were categorized according to a methodological framework. The health concept set forth by local social actors contributed to the non-inclusion of oral healthcare teams (OHTs) in the FHS. This theorization identified the origins of the studied phenomenon and can aid in future policy decision-making carried out by local social actors. theorize conception noninclusion non inclusion FHS (FHS Fora Gerais Brazil qualitative exploratory descriptive Policy managers council service process diseasecentered disease centered model category framework OHTs (OHTs decisionmaking decision making

https://doi.org/10.1590/1413-81232023284.12502022

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