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1.
A new method of adhesive system application improves the bond strength between fiber post and root dentin
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Nesello, Rafael
; Jahnke, Leonardo Thomasi
; Krabbe, Wesley Misael
; Agnol Júnior, Charles André Dall
; Santini, Manuela Favarin
; Silveira, Lucas Machado
; Miotti, Leonardo
; Só, Marcus Vinícius Reis
; Rosa, Ricardo Abreu da
.
Resumo Este estudo avaliou o efeito de um novo método para aplicação do sistema adesivo na resistência de união entre pino de fibra e dentina radicular usando dois sistemas adesivos. Os canais de sessenta incisivos bovinos foram preparados e obturados. As raízes foram divididas em seis grupos (n=10) de acordo com o sistema adesivo (Clearfil SE - CSE e Single Bond Universal - SBU) e com a estratégia de aplicação (microbrush - MB, escova rotatória - RB e inserto ultrassônico - US). Os pinos de fibra foram cimentados utilizando cimento resinoso (RelyX ARC). As raízes foram seccionadas perpendicularmente ao seu longo eixo e três fatias foram obtidas. Previamente ao teste de push-out, foi realizada microscopia de varredura confocal a laser para ilustrar a adaptação interfacial do cimento às paredes do canal radicular. Os padrões de falha foram analisados com magnificação de 40x. O teste de Shapiro-Wilk indicou distribuição normal dos dados. Os valores de resistência de união foram comparados usando o teste ANOVA de uma via e post hoc de Tukey. As diferenças entre os sistemas adesivos em cada terço e de acordo com cada protocolo foram analisadas pelo teste T de Student. O nível de significância foi de 5%. CSE aplicado com RB apresentou maiores valores médios de resistência de união do que quando aplicado com MB (técnica convencional) (P<0,05). Aplicação com US apresentou valores intermediários de resistência de união para o CSE (P>0,05). A aplicação do SBU utilizando RB gerou maiores valores médios de resistência de união comparados com MB e US (P<0,05). Falhas adesivas foram predominantes (65,5%). A aplicação do CSE e SBU com a nova escova rotatória melhorou a resistência de união dos pinos de fibra à dentina radicular comparados com a estratégia convencional. obturados n=10 n10 n 10 (n=10 Clearfil microbrush US. . US) RelyX ARC. ARC ARC) obtidas pushout, pushout push out, out push-out 40x x ShapiroWilk Shapiro Wilk dados Tukey Student 5 5% técnica convencional P<0,05. P005 P P<0,05 0 05 (P<0,05) P>0,05. P>0,05 (P>0,05) 65,5%. 655 65,5% 65 (65,5%) n=1 n1 1 (n=1 P00 P<0,0 (P<0,05 P>0,0 (P>0,05 65,5 6 (65,5% n= (n= P0 P<0, (P<0,0 P>0, (P>0,0 65, (65,5 (n P<0 (P<0, P>0 (P>0, (65, P< (P<0 P> (P>0 (65 (P< (P> (6 (P (
Abstract This study evaluated a new method of adhesive system application on the bond strength between fiber post and root dentin using two adhesive systems. The canals of sixty bovine incisors were prepared and obturated. The roots were divided into six groups (n=10) according to the adhesive system (Clearfil SE - CSE and Single Bond Universal - SBU) and the application strategy (microbrush - MB; rotary brush - RB; and ultrasonic tip - US). The glass fiber posts were cemented with resin cement (RelyX ARC). The roots were sectioned perpendicularly to their long axis, and three slices per root were obtained. Previously to the push-out test, confocal laser scanning microscopy (CLSM) was performed to illustrate the interfacial adaptation of the cement to the root canal walls. Failure patterns were analyzed with 40x magnification. Shapiro-Wilk indicated a normal distribution of the data. The bond strength values were compared using one-way ANOVA and Tukey's tests. Student's T test analyzed the differences between the adhesive systems within each third and protocol. A significance level of 5% was used. CSE with RB showed higher mean bond strength values compared to MB (conventional technique) (P < 0.05). US application resulted in intermediate bond strength values for CSE (P > 0.05). The application of SBU using RB generated higher mean bond strength values compared to MB and US (P < 0.05). Adhesive failures were predominant (65.5%). CSE and SBU application with the new rotary brush improved the bond strength of fiber posts to root dentin compared to the conventional strategy. obturated n=10 n10 n 10 (n=10 Clearfil microbrush US. . US) RelyX ARC. ARC ARC) axis obtained pushout push out CLSM (CLSM walls x magnification ShapiroWilk Shapiro Wilk data oneway one way Tukeys Tukey s tests Students Student protocol 5 used technique P 0.05. 005 0.05 0 05 0.05) 65.5%. 655 65.5% 65 (65.5%) n=1 n1 1 (n=1 00 0.0 65.5 6 (65.5% n= (n= 0. 65. (65.5 (n (65. (65 (6 (
2.
Comparative study of two laboratory techniques for the detection of HLA-B27 in patients with axial spondyloarthritis: a cross-sectional analysis HLAB27 HLAB HLA B27 B HLA-B2 spondyloarthritis crosssectional cross sectional HLAB2 B2 HLA-B
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Angeli, Ricardo dos Santos
; Ribeiro, André Lucas
; Kohem, Charles Lubianca
; Xavier, Ricardo Machado
; Monticielo, Odirlei André
.
Abstract Background The diagnostic and prognostic relevance of Human Leukocyte Antigen B-27 (HLA-B27) in Axial Spondyloarthritis (AxSpA) is undeniable, with 70% of Ankylosing Spondylitis (AS) patients carrying the B27 gene, contrasted with a mere 4.35% in the general population. Flow cytometry (FC) and Polymerase Chain Reaction (PCR) have emerged as the predominant techniques for routine HLA-B27 typing. While various studies have compared these methods, none have catered to the unique characteristics of the Brazilian demographic. Therefore, this research aims to compare FC and PCR in a Brazilian cohort diagnosed with AxSpA. Methods An analytical cross-sectional study was undertaken involving 62 AxSpA outpatients from a Brazilian University Hospital. Both FC and PCR-SSP assays were utilized to ascertain HLA-B27 typing. The outcomes (either confirming or refuting the allele’s presence) underwent rigorous scrutiny. Agreement between the methodologies was assessed using the kappa statistic. A p-value of < 0.05 was deemed statistically significant. Results Of the participants, 90.3% (n= 56) were HLA-B27 positive according to FC, while 79% (n= 49) were identified as positive using the PCR method. FC exhibited a sensitivity rate of 98% paired with a specificity of 38.5%. The Positive Predictive Value for FC stood at 85.7%, and the Negative Predictive Value was 83.5%. Consequently, the overall accuracy of the FC method was gauged at 85.5%. A kappa coefficient of κ = 0.454 was derived. Conclusions FC demonstrated noteworthy sensitivity and satisfactory accuracy in HLA-B27 detection, albeit with a reduced specificity when contrasted with PCR-SSP. Nevertheless, given its cost-effectiveness and streamlined operation relative to PCR, FC remains a pragmatic option for preliminary screening in clinical practice, especially in low-income regions. To optimize resource allocation, we advocate for a refined algorithm that initiates by assessing the relevance of HLA-B27 typing based on Choosing Wisely recommendations. It then leans on FC, and, if results are negative yet clinical suspicion persists, advances to PCR. This approach aims to balance diagnostic accuracy and financial prudence, particularly in regions contending with escalating medical costs. B 27 B-2 HLAB27 HLAB HLA (HLA-B27 (AxSpA undeniable 70 AS (AS B2 gene 435 4 35 4.35 population (FC (PCR HLA-B2 methods demographic Therefore crosssectional cross sectional 6 Hospital PCRSSP SSP either alleles allele s presence scrutiny statistic pvalue p value 005 0 05 0.0 significant participants 903 90 3 90.3 n= n (n 56 79 49 98 385 38 5 38.5% 857 85 7 85.7% 835 83 83.5% Consequently 855 85.5% 0454 454 0.45 derived detection PCRSSP. SSP. Nevertheless costeffectiveness cost effectiveness practice lowincome low income allocation recommendations persists prudence costs 2 B- HLAB2 (HLA-B2 43 4.3 HLA-B 00 0. 9 90. 38.5 8 85.7 83.5 85.5 045 45 0.4 (HLA-B 4. 38. 85. 83. 04
3.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
; Lucena, Carlos A.S. de
; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
; Dias, Cristina de O.
; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
; Toledo, Daniela G.P. de
; Takiya, Daniela M.
; Fernandes, Daniell R.R.
; Ament, Danilo C.
; Cordeiro, Danilo P.
; Silva, Darliane E.
; Pollock, Darren A.
; Muniz, David B.
; Gibson, David I.
; Nogueira, David S.
; Marques, Dayse W.A.
; Lucatelli, Débora
; Garcia, Deivys M.A.
; Baêta, Délio
; Ferreira, Denise N.M.
; Rueda-Ramírez, Diana
; Fachin, Diego A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Pádua, Diego G. de
; Barbosa, Diego N.
; Dolibaina, Diego R.
; Amaral, Diogo C.
; Chandler, Donald S.
; Maccagnan, Douglas H.B.
; Caron, Edilson
; Carvalho, Edrielly
; Adriano, Edson A.
; Abreu Júnior, Edson F. de
; Pereira, Edson H.L.
; Viegas, Eduarda F.G.
; Carneiro, Eduardo
; Colley, Eduardo
; Eizirik, Eduardo
; Santos, Eduardo F. dos
; Shimbori, Eduardo M.
; Suárez-Morales, Eduardo
; Arruda, Eliane P. de
; Chiquito, Elisandra A.
; Lima, Élison F.B.
; Castro, Elizeu B. de
; Orlandin, Elton
; Nascimento, Elynton A. do
; Razzolini, Emanuel
; Gama, Emanuel R.R.
; Araujo, Enilma M. de
; Nishiyama, Eric Y.
; Spiessberger, Erich L.
; Santos, Érika C.L. dos
; Contreras, Eugenia F.
; Galati, Eunice A.B.
; Oliveira Junior, Evaldo C. de
; Gallardo, Fabiana
; Hernandes, Fabio A.
; Lansac-Tôha, Fábio A.
; Pitombo, Fabio B.
; Dario, Fabio Di
; Santos, Fábio L. dos
; Mauro, Fabio
; Nascimento, Fabio O. do
; Olmos, Fabio
; Amaral, Fabio R.
; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
; Schmitz, Hermes J.
; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
; Quintino, Hingrid Y.S.
; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
; Franz, Ismael
; Fernandes, Itanna O.
; Golfetti, Ivan F.
; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
; Narita, João P.
; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
; Fernandes, Jose A.M.
; Pacheco, José F.
; Birindelli, José L.O.
; Rezende, José M.
; Avendaño, Jose M.
; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
; Pujol-Luz, José R.
; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
; Donahue, Julian P.
; Alvim, Juliana
; Almeida, Juliana C.
; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
; Kuabara, Kamila M.D.
; Nascimento, Karine B.
; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
; Miranda, Lucília S.
; Salik, Lucy M.
; Bezerra, Luis E.A.
; Silveira, Luis F.
; Campos, Luiz A.
; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
; Cruz, Luiza S. da
; Sekerka, Lukas
; Barros, Lurdiana D.
; Santos, Luziany Q.
; Skoracki, Maciej
; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
; Araújo, Marcel S. de
; Monné, Marcela L.
; Labruna, Marcelo B.
; Santis, Marcelo D. de
; Duarte, Marcelo
; Knoff, Marcelo
; Nogueira, Marcelo
; Britto, Marcelo R. de
; Melo, Marcelo R.S. de
; Carvalho, Marcelo R. de
; Tavares, Marcelo T.
; Kitahara, Marcelo V.
; Justo, Marcia C.N.
; Botelho, Marcia J.C.
; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
; Oliveira, Marcio L. de
; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
; Loeb, Marina V.
; Cohn-Haft, Mario
; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
; Rocha, Matheus dos S.
; Martins, Maurício L.
; Segura, Melissa O.
; Cardenas, Melissa Q.
; Duarte, Mércia E.
; Ivie, Michael A.
; Mincarone, Michael M.
; Borges, Michela
; Monné, Miguel A.
; Casagrande, Mirna M.
; Fernandez, Monica A.
; Piovesan, Mônica
; Menezes, Naércio A.
; Benaim, Natalia P.
; Reategui, Natália S.
; Pedro, Natan C.
; Pecly, Nathalia H.
; Ferreira Júnior, Nelson
; Silva Júnior, Nelson J. da
; Perioto, Nelson W.
; Hamada, Neusa
; Degallier, Nicolas
; Chao, Ning L.
; Ferla, Noeli J.
; Mielke, Olaf H.H.
; Evangelista, Olivia
; Shibatta, Oscar A.
; Oliveira, Otto M.P.
; Albornoz, Pablo C.L.
; Dellapé, Pablo M.
; Gonçalves, Pablo R.
; Shimabukuro, Paloma H.F.
; Grossi, Paschoal
; Rodrigues, Patrícia E. da S.
; Lima, Patricia O.V.
; Velazco, Paul
; Santos, Paula B. dos
; Araújo, Paula B.
; Silva, Paula K.R.
; Riccardi, Paula R.
; Garcia, Paulo C. de A.
; Passos, Paulo G.H.
; Corgosinho, Paulo H.C.
; Lucinda, Paulo
; Costa, Paulo M.S.
; Alves, Paulo P.
; Roth, Paulo R. de O.
; Coelho, Paulo R.S.
; Duarte, Paulo R.M.
; Carvalho, Pedro F. de
; Gnaspini, Pedro
; Souza-Dias, Pedro G.B.
; Linardi, Pedro M.
; Bartholomay, Pedro R.
; Demite, Peterson R.
; Bulirsch, Petr
; Boll, Piter K.
; Pereira, Rachel M.M.
; Silva, Rafael A.P.F.
; Moura, Rafael B. de
; Boldrini, Rafael
; Silva, Rafaela A. da
; Falaschi, Rafaela L.
; Cordeiro, Ralf T.S.
; Mello, Ramon J.C.L.
; Singer, Randal A.
; Querino, Ranyse B.
; Heleodoro, Raphael A.
; Castilho, Raphael de C.
; Constantino, Reginaldo
; Guedes, Reinaldo C.
; Carrenho, Renan
; Gomes, Renata S.
; Gregorin, Renato
; Machado, Renato J.P.
; Bérnils, Renato S.
; Capellari, Renato S.
; Silva, Ricardo B.
; Kawada, Ricardo
; Dias, Ricardo M.
; Siewert, Ricardo
; Brugnera, Ricaro
; Leschen, Richard A.B.
; Constantin, Robert
; Robbins, Robert
; Pinto, Roberta R.
; Reis, Roberto E. dos
; Ramos, Robson T. da C.
; Cavichioli, Rodney R.
; Barros, Rodolfo C. de
; Caires, Rodrigo A.
; Salvador, Rodrigo B.
; Marques, Rodrigo C.
; Araújo, Rodrigo C.
; Araujo, Rodrigo de O.
; Dios, Rodrigo de V.P.
; Johnsson, Rodrigo
; Feitosa, Rodrigo M.
; Hutchings, Roger W.
; Lara, Rogéria I.R.
; Rossi, Rogério V.
; Gerstmeier, Roland
; Ochoa, Ronald
; Hutchings, Rosa S.G.
; Ale-Rocha, Rosaly
; Rocha, Rosana M. da
; Tidon, Rosana
; Brito, Rosangela
; Pellens, Roseli
; Santos, Sabrina R. dos
; Santos, Sandra D. dos
; Paiva, Sandra V.
; Santos, Sandro
; Oliveira, Sarah S. de
; Costa, Sávio C.
; Gardner, Scott L.
; Leal, Sebastián A. Muñoz
; Aloquio, Sergio
; Bonecker, Sergio L.C.
; Bueno, Sergio L. de S.
; Almeida, Sérgio M. de
; Stampar, Sérgio N.
; Andena, Sérgio R.
; Posso, Sergio R.
; Lima, Sheila P.
; Gadelha, Sian de S.
; Thiengo, Silvana C.
; Cohen, Simone C.
; Brandão, Simone N.
; Rosa, Simone P.
; Ribeiro, Síria L.B.
; Letana, Sócrates D.
; Santos, Sonia B. dos
; Andrade, Sonia C.S.
; Dávila, Stephane
; Vaz, Stéphanie
; Peck, Stewart B.
; Christo, Susete W.
; Cunha, Suzan B.Z.
; Gomes, Suzete R.
; Duarte, Tácio
; Madeira-Ott, Taís
; Marques, Taísa
; Roell, Talita
; Lima, Tarcilla C. de
; Sepulveda, Tatiana A.
; Maria, Tatiana F.
; Ruschel, Tatiana P.
; Rodrigues, Thaiana
; Marinho, Thais A.
; Almeida, Thaís M. de
; Miranda, Thaís P.
; Freitas, Thales R.O.
; Pereira, Thalles P.L.
; Zacca, Thamara
; Pacheco, Thaynara L.
; Martins, Thiago F.
; Alvarenga, Thiago M.
; Carvalho, Thiago R. de
; Polizei, Thiago T.S.
; McElrath, Thomas C.
; Henry, Thomas
; Pikart, Tiago G.
; Porto, Tiago J.
; Krolow, Tiago K.
; Carvalho, Tiago P.
; Lotufo, Tito M. da C.
; Caramaschi, Ulisses
; Pinheiro, Ulisses dos S.
; Pardiñas, Ulyses F.J.
; Maia, Valéria C.
; Tavares, Valeria
; Costa, Valmir A.
; Amaral, Vanessa S. do
; Silva, Vera C.
; Wolff, Vera R. dos S.
; Slobodian, Verônica
; Silva, Vinícius B. da
; Espíndola, Vinicius C.
; Costa-Silva, Vinicius da
; Bertaco, Vinicius de A.
; Padula, Vinícius
; Ferreira, Vinicius S.
; Silva, Vitor C.P. da
; Piacentini, Vítor de Q.
; Sandoval-Gómez, Vivian E.
; Trevine, Vivian
; Sousa, Viviane R.
; Sant’Anna, Vivianne B. de
; Mathis, Wayne N.
; Souza, Wesley de O.
; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
4.
A needle in a haystack? The impact of a targeted epilepsy gene panel in the identification of a treatable but rapidly progressive metabolic epilepsy: CLN2 disease haystack CLN
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Lourenço, Charles Marques
; Sallum, Juliana Maria Ferraz
; Pereira, Alessandra Marques
; Girotto, Paula Natale
; Kok, Fernando
; Vilela, Daniel Reda Fenga
; Barron, Erika
; Pessoa, André
; de Oliveira, Bibiana Mello
.
Resumo Antecedentes As lipofuscinoses ceroides neuronais (neuronal ceroid lipofuscinoses, NCLs, em inglês) são um grupo de doenças autossômicas recessivas, hereditárias, lisossomais e neurodegenerativas que causam demência progressiva, crises epiléticas, distúrbios de movimento, atraso/regressão da linguagem, deficiência visual progressiva e morte precoce. A lipofuscinose ceroide neuronal tipo 2 (neuronal ceroid lipofuscinosis type 2, CLN2, em inglês), causada por variantes patogênicas bialélicas do gene TPP1, é a única com terapia-alvo aprovada. O diagnóstico laboratorial é realizado por testes específicos, o que leva a atrasos diagnósticos e, consequentemente, prejudica a disponibilização de tratamento. A epilepsia é uma característica comum e clinicamente identificável entre as NCLs, e o início das convulsões é o principal motivo para as famílias buscarem atendimento médico. Objetivo Avaliar os resultados do Programa de Epilepsia e Genética da América Latina, um painel genético, como uma ferramenta abrangente para a investigação de CLN2 entre outras causas genéticas de epilepsia. Métodos Um total de 1.284 pacientes com epilepsia sem uma causa específica e que tinham pelo menos 1 sintoma associado à CLN2 foram rastreados em busca de variantes em 160 genes associados à epilepsia ou a distúrbios metabólicos que apresentam epilepsia, por meio de um painel genético. Resultados Variantes do gene TPP1 foram identificadas em 25 indivíduos (1,9%), sendo que ; 21 apresentavam duas variantes. As duas variantes mais frequentes foram p.Arg208* e p.Asp276Val, e duas variantes novas foram detectadas neste: p.Leu308Pro e c.89 + 3G > C Intron 2. Conclusão Os resultados sugerem que os painéis genéticos de epilepsia podem ser uma ferramenta útil para confirmar ou excluir o diagnóstico de CLN2 e, se confirmado, fornecer tratamento específico para os pacientes. NCLs inglês recessivas hereditárias epiléticas movimento atrasoregressão atraso regressão linguagem precoce CLN inglês, , TPP terapiaalvo terapia alvo aprovada específicos consequentemente médico Latina genético 1284 284 1.28 16 1,9%, 19 1,9% 9 (1,9%) pArg208 pArg p Arg208 Arg p.Arg208 pAsp276Val pAspVal Asp276Val Asp Val p.Asp276Val neste pLeu308Pro pLeuPro Leu308Pro Leu Pro c89 c 89 c.8 G confirmado 128 28 1.2 1,9 (1,9% pArg20 Arg20 p.Arg20 pAsp AspVal pLeu LeuPro c8 8 c. 12 1. 1, (1,9 pArg2 Arg2 p.Arg2 (1, p.Arg (1 (
Abstract Background Neuronal ceroid lipofuscinoses (NCL) are a group of autosomal recessive, inherited, lysosomal, and neurodegenerative diseases that causes progressive dementia, seizures, movement disorders, language delay/regression, progressive visual failure, and early death. Neuronal ceroid lipofuscinosis type 2 (CLN2), caused by biallelic pathogenic variants of the TPP1 gene, is the only NCL with an approved targeted therapy. The laboratory diagnosis of CLN2 is established through highly specific tests, leading to diagnostic delays and eventually hampering the provision of specific treatment for patients with CLN2. Epilepsy is a common and clinically-identifiable feature among NCLs, and seizure onset is the main driver for families to seek medical care. Objective To evaluate the results of the Latin America Epilepsy and Genetics Program, an epilepsy gene panel, as a comprehensive tool for the investigation of CLN2 among other genetic causes of epilepsy. Methods A total of 1,284 patients with epilepsy without a specific cause who had at least 1 symptom associated with CLN2 were screened for variants in 160 genes associated with epilepsy or metabolic disorders presenting with epilepsy through an epilepsy gene panel. Results Variants of the TPP1 gene were identified in 25 individuals (1.9%), 21 of them with 2 variants. The 2 most frequently reported variants were p.Arg208* and p.Asp276Val, and 2 novel variants were detected in the present study: p.Leu308Pro and c.89 + 3G > C Intron 2. Conclusion The results suggest that these genetic panels can be very useful tools to confirm or exclude CLN2 diagnosis and, if confirmed, provide disease-specific treatment for the patients. (NCL recessive inherited lysosomal dementia seizures delayregression delay regression delay/regression failure death CLN2, CLN , (CLN2) TPP therapy tests clinicallyidentifiable clinically identifiable NCLs care Program panel 1284 284 1,28 16 1.9%, 19 1.9% 9 (1.9%) pArg208 pArg p Arg208 Arg p.Arg208 pAsp276Val pAspVal Asp276Val Asp Val p.Asp276Val study pLeu308Pro pLeuPro Leu308Pro Leu Pro c89 c 89 c.8 G confirmed diseasespecific disease (CLN2 128 28 1,2 1.9 (1.9% pArg20 Arg20 p.Arg20 pAsp AspVal pLeu LeuPro c8 8 c. (CLN 12 1, 1. (1.9 pArg2 Arg2 p.Arg2 (1. p.Arg (1 (
5.
Study of meningeal enhancement in magnetic resonance imaging in dogs with central nervous system diseases
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Guedes, Charles H.
; Sousa, Mariana P.
; Moraes, Alessandra R.D.P.
; Filadelpho, André L.
; Machado, Vânia M.V.
.
RESUMO: A ressonância magnética (RM) tem papel importante na detecção e caracterização das lesões meníngeas, auxiliando um possível diagnóstico clínico ante mortem de doenças intracranianas. O realce meníngeo tem sido descrito como um sinal de múltiplas enfermidades do sistema nervoso central (SNC). O objetivo deste estudo foi avaliar o realce meníngeo nas RM do encéfalo de cães e associá-las às diferentes doenças do SNC. Foi realizado um estudo retrospectivo de 22 cães submetidos ao exame de RM, com o histórico de sinais clínicos de doença neurológica como critério de inclusão para seleção destes animais ao estudo. Os dados foram divididos de acordo com a idade e sexo dos animais e os critérios de análise foram, quanto às enfermidades do SNC encontradas, local, padrão e definição do realce da meninge. Os resultados obtidos demonstram que, dentre as doenças observadas, a encefalite e a neoplasia ocorrem com maior frequência, ambas com 22,7% de suspeitas clínicas. O local de maior incidência foi determinado como sendo o parietal/temporal/frontal, com 27,3% de prevalência, seguido do frontal com 18,2%. Com relação ao padrão da meninge, foi verificado que houve 90,9% mais realce na região pial e dural conjuntamente do que ao compará-las individualmente. Já ao avaliar a definição do realce meníngeo, o mais observado foi o realce discreto (59,1%). O presente estudo possibilitou a obtenção de informações específicas e maior compreensão das características do realce meningeal, incluindo dois padrões de realce meníngeo (pial e dural) e a identificação da associação dos valores nas diferentes doenças do SNC em cães. RESUMO (RM meníngeas intracranianas . (SNC) associálas associá las 2 encontradas meninge observadas frequência 227 7 22,7 clínicas parietaltemporalfrontal parietal temporal parietal/temporal/frontal 273 27 3 27,3 prevalência 182 18 18,2% 909 90 9 90,9 comparálas compará individualmente 59,1%. 591 59,1% 59 1 (59,1%) meningeal (SNC 22, 27, 18,2 90, 59,1 5 (59,1% 18, 59, (59,1 (59, (59 (5 (
ABSTRACT: Magnetic resonance imaging (MRI) plays an important role in detecting and characterizing meningeal lesions, thus assisting in a possible ante mortem clinical diagnosis of intracranial diseases. Meningeal enhancement has been described as a sign of multiple central nervous system (CNS) disorders. The aim of this study was to evaluate meningeal enhancement on MRI of the brain of dogs and to associate them with different CNS diseases. A retrospective study of 22 dogs submitted to MRI was carried out, with a history of clinical signs of neurological diseases as an inclusion criterion for selecting these animals for the study. The data were divided according to the age and sex of the animals, and the analysis criteria were regarding the CNS diseases found, location, pattern and definition of meningeal enhancement. The results demonstrate that encephalitis and neoplasia occur more frequently among the diseases observed, with 22.7% of clinical suspicions. The site with the highest incidence was the parietal/temporal/frontal, with a 27.3% prevalence, followed by the frontal, with 18.2%. Regarding the meningeal pattern, it was found that there was 90.9% more enhancement in the pial and dural regions together than when comparing them individually. When evaluating the definition of meningeal enhancement, slight enhancement was most observed (59.1%). The present study made it possible to obtain specific information and better understand the characteristics of meningeal enhancement, including two patterns of meningeal enhancement (pial and dural) and identifying the association of values in different CNS diseases in dogs. ABSTRACT (MRI lesions (CNS disorders 2 out location 227 7 22.7 suspicions parietaltemporalfrontal parietal temporal frontal parietal/temporal/frontal 273 27 3 27.3 prevalence 182 18 18.2% 909 90 9 90.9 individually 59.1%. 591 59.1% . 59 1 (59.1%) 22. 27. 18.2 90. 59.1 5 (59.1% 18. 59. (59.1 (59. (59 (5 (
6.
Development of a questionnaire to assess the patient perspective regarding challenges in psoriatic arthritis treatment—a mixed-methods study treatmenta treatment mixedmethods mixed methods
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Ribeiro, André Lucas
; Tessari, Júlia Andressa
; Kohem, Charles Lubianca
; Palominos, Penélope Esther
; Chakr, Rafael Mendonça da Silva
.
Abstract Background Limited data exist on psoriatic arthritis (PsA) treatment in lower-income regions, particularly from the patient perspective. This study explores the challenges faced by socioeconomically vulnerable PsA patients and the reasons for non-adherence to treatment guidelines. The main objective of the study is to develop a questionnaire to identify the primary challenges in PsA treatment adherence and to analyze its feasibility while simultaneously understanding the target population's unique characteristics. Methods We included PsA patients meeting the Classification Criteria for PsA (CASPAR), excluding those with other overlapping inflammatory diseases. The study, supported by two patient-research partners, began with focus groups to identify treatment challenges, leading to the creation of a 26-item questionnaire. Its reliability was verified using the test-retest method, targeting a percent agreement ≥ 0.8. Then, PsA patients at a rheumatology clinic completed the final survey. Results The study involved 69 PsA patients. The final questionnaire contained 26-questions across five-domains, with a 92.2% agreement rate and an average completion time of 8.3 minutes. Diagnostic delays exceeded a year for 59% of patients and more than two years for 33%. Daily life disruptions affected 43.2% of patients, with 35.3% taking sick leave or retiring. Around 25% waited over 8 weeks for drug approval, and 17.6% required legal intervention to access medication. Drug dispensation issues impacted about 60% of patients. Furthermore, 66.7% lived far from their rheumatologist, with 49% traveling over an hour for appointments. Approximately 30% were unaware of the risks of methotrexatein relation to alcohol consumption and pregnancy. Conclusions The questionnaire was feasible and reliable, with its results underscoring patient-centric challenges in PsA management, particularly concerning diagnostic delays and medication access, as well as daily life disruptions and misinformation. These findings emphasize the urgency for healthcare reforms aimed at improving diagnosis efficiency, patient education, and streamlined medication access, emphasizing the need for tailored initiatives to improve the healthcare experience for PsA patients. (PsA lowerincome lower income regions perspective nonadherence non guidelines populations population s characteristics CASPAR, CASPAR , (CASPAR) diseases patientresearch research partners 26item item 26 testretest test retest method 08 0 0.8 Then survey 6 26questions questions fivedomains, fivedomains five domains, domains five-domains 922 92 2 92.2 83 3 8. minutes 59 33 33% 432 43 43.2 353 35 35.3 retiring 25 approval 176 17 17.6 60 Furthermore 667 66 7 66.7 rheumatologist 49 appointments 30 pregnancy reliable patientcentric centric management misinformation efficiency education (CASPAR 0. 9 92. 5 4 43. 35. 1 17. 66.
7.
Alzheimer's disease: an epidemiological analysis over the number of hospitalizations and deaths in Brazil Alzheimers Alzheimer s disease
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Piovesan, Eduardo Cattapan
; Freitas, Bruna Zanatta de
; Lemanski, Francisco Costa Beber
; Carazzo, Charles André
.
Resumo Antecedentes A doença de Alzheimer (DA) é uma doença neurodegenerativa caracterizada pelo comprometimento da função cognitiva. Resulta em uma alta taxa de morbimortalidade, por meio de um número significativo de óbitos e internações, gerando um alto custo ao sistema de saúde. Objetivo Realizar uma análise epidemiológica, utilizando as variáveis citadas abaixo, por DA como principal diagnóstico, no Brasil, entre 2010 e 2020, a fim de contribuir para um melhor entendimento da doença e suas implicações. Métodos Estudo analítico, observacional, longitudinal e retrospectivo. Os dados foram extraídos do Departamento de Informática do Sistema Único de Saúde (DATASUS). As variáveis utilizadas foram número de internações, custo total gasto, custo médio por internação, tempo médio de internação, número de óbitos nas internações, taxa de mortalidade por internação, número de óbitos absolutos, sexo, faixa etária, região e raça. Resultados De 2010 a 2020, foram registrados 188.811 óbitos e 13.882 internações por DA, com um gasto total de R$ 25.953.019,40 em internações. O tempo médio de permanência no hospital foi de 25 dias. Em 11 anos, houve aumento da mortalidade, internações e custo total; por outro lado, o tempo médio de permanência, no mesmo período, diminuiu. Conclusão A DA, nos anos avaliados, representa uma parcela significativa das internações hospitalares, gerando um custo significativo ao sistema de saúde, além do número de óbitos. Estes dados são importantes para gerar esforços conjuntos para evitar internações desses pacientes, a fim de minimizar o impacto no Sistema de Saúde. (DA cognitiva morbimortalidade saúde epidemiológica abaixo diagnóstico Brasil 201 2020 implicações analítico observacional retrospectivo DATASUS. DATASUS . (DATASUS) internação absolutos sexo etária raça 188811 188 811 188.81 13882 13 882 13.88 R 2595301940 953 019 40 25.953.019,4 2 dias 1 lado período diminuiu avaliados hospitalares pacientes 20 202 (DATASUS 18881 18 81 188.8 1388 88 13.8 259530194 95 01 4 25.953.019, 1888 8 188. 138 13. 25953019 9 0 25.953.019 2595301 25.953.01 259530 25.953.0 25953 25.953. 2595 25.953 259 25.95 25.9 25.
Abstract Background Alzheimer's disease (AD) is a neurodegenerative condition characterized by impaired cognitive function. It results in high morbidity, including a large number of hospitalizations, and mortality, generating high costs to health systems. Objective The present epidemiological analysis evaluated the number of hospitalizations and deaths by AD as the main diagnosis in Brazil between 2010 and 2020. This endeavor should contribute to a better understanding of the disease and its implications. Methods The present analytical, observational, longitudinal, and retrospective study used data extracted from the Department of Informatics of the Brazilian Unified Health System (DATASUS, in the Portuguese acronym). The variables include the number of hospitalizations, the total cost spent, the average cost per hospitalization, the average length of hospital stay, the number of deaths during hospitalization, the mortality rate per hospitalization, sex, age group, region, and race. Results From 2010 to 2020, there were 188,811 deaths and 13,882 hospitalizations for AD, with a total expenditure of BRL 25,953,019.40 in hospitalizations. The average length of hospital stay was 25 days. Over the considered period, mortality, the number of hospitalizations, and the total cost increased while the average length of stay decreased. Conclusion From 2010 to 2020, AD represented a large portion of hospital admissions, generating a significant cost to the health system and a large number of deaths. These data are important to undertake joint efforts to prevent hospitalizations of these patients in order to minimize impacts on the health system. Alzheimers Alzheimer s (AD function morbidity systems 201 2020 implications analytical observational longitudinal DATASUS, DATASUS (DATASUS acronym. acronym . acronym) spent hospitalization sex group region race 188811 188 811 188,81 13882 13 882 13,88 2595301940 953 019 40 25,953,019.4 2 days period decreased admissions 20 202 18881 18 81 188,8 1388 1 88 13,8 259530194 95 01 4 25,953,019. 1888 8 188, 138 13, 25953019 9 0 25,953,019 2595301 25,953,01 259530 25,953,0 25953 25,953, 2595 25,953 259 25,95 25,9 25,
8.
Antioxidants and cardioprotective effects of ethyl acetate fraction of Canavalia rosea leaves in myocardial ischemia-reperfusion injury ischemiareperfusion ischemia reperfusion
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FEITOSA, MARAÍSA B.J.
; ARAÚJO, SILVAN S.
; MESQUITA, THÁSSIO RICARDO R.
; GIODA, CAROLINA R.
; SÁ, LUCAS A. DE
; ALMEIDA, GRACE KELLY M.
; MIGUEL-DOS-SANTOS, RODRIGO
; BARBOSA, ANDRIELE M.
; VASCONCELOS, CARLA MARIA L. DE
; CAMARGO, ENILTON A.
; BARREIROS, ANDRÉ LUÍS B.S.
; ESTEVAM, CHARLES S.
; MORAES, ÉDER RICARDO DE
; AMARAL, RICARDO G.
; LAUTON-SANTOS, SANDRA
.
Anais da Academia Brasileira de Ciências
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Abstract Different degrees in the biological activities of Canavalia rosea had been previously reported . In this study, our group assessed the cardioprotective effects of the ethyl acetate fraction (EAcF) of the Canavalia rosea leaves. Firstly, it was confirmed, by in vitro approach, that the EAcF has high antioxidant properties due to the presence of important secondary metabolites, as flavonoids. In order to explore their potential protector against cardiovascular disorders, hearts were previously perfused with EAcF (300 μg.mL-1) and submitted to the global ischemia followed by reperfusion in Langendorff system. The present findings have demonstrated that EAcF restored the left ventricular developed pressure and decreased the arrhythmias severity index. Furthermore, EAcF significantly increased the glutathiones peroxidase activity with decreased malondialdehyde and creatine kinase levels. EAcF was effective upon neither the superoxide dismutase, glutationes reductase nor the catalase activities. In addition, the Western blot analysis revealed that ischemia-reperfusion injury significantly upregulates caspase 3 protein expression, while EAcF abolishes this effect. These results provide evidence that the EAcF reestablishes the cardiac contractility and prevents arrhythmias; it is suggested that EAcF could be used to reduce injury caused by cardiac reperfusion. However more clinical studies should be performed, before applying it in the clinic. study (EAcF leaves Firstly confirmed approach metabolites flavonoids disorders 300 (30 μg.mL1 μgmL1 μgmL μg.mL 1 μg mL μg.mL-1 system index Furthermore levels dismutase addition ischemiareperfusion expression effect performed clinic 30 (3 mL1 μg.mL- (
9.
Combined BLUP selection indexes with parents and F2 populations in soybean (Glycine max) breeding F Glycine max
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Bezerra, André Ricardo Gomes
; Resende, Marcos Deon Vilela de
; Silva, Felipe Lopes da
; Sediyama, Tuneo
; Cruz, Cosme Damião
; Silva, Francisco Charles dos Santos
; Silva, Amilton Ferreira da
.
Abstract This study aimed to apply selection indexes in situations in which F2 populations and their parents are evaluated simultaneously in field trials to predict population genotypic values and selecting the best populations. Fifteen F2 soybean populations were evaluated for number of days to flowering and to maturity and grain yield. The data was analyzed using restricted maximum likelihood/best linear unbiased prediction (REML/BLUP) to obtain genotypic effects, variance components and accuracies. Four selection methods were compared: genotypic values of the F2 populations (gF2), combined index with the mean genotypic value of parents and F2 population (Ia) and two indexes that add (to gF2 and to Ia) and consider genetic variability within populations (Ib and Ic). The index Ia presented a result similar to that obtained with the gF2 selection method. Selection indexes (Ib and Ic) based on several sources of information were more efficient than selection based on gF2 values only. F yield likelihoodbest likelihood REML/BLUP REMLBLUP REML BLUP (REML/BLUP effects accuracies compared gF2, gF , (gF2) (Ia Ib Ic. Ic . method only (gF2 (gF
10.
[SciELO Preprints] - Guideline of the Brazilian Society of Cardiology on Diagnosis and Treatment of Patients with Chagas Disease Cardiomyopathy
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Marin-Neto, José Antonio
Rassi Jr., Anis
Moraes Oliveira, Gláucia M.
Lemos Correia, Luís Claudio
Novaes Ramos Jr., Alberto
Hasslocher-Moreno, Alejandro Marcel
Luquetti Ostermayer, Alejandro
Sousa, Andréa Silvestre de
Amato Vincenzo de Paola, Angelo
Sobral de Sousa, Antonio Carlos
Pinho Ribeiro, Antonio Luiz
Correia Filho, Dalmo
Moraes de Souza, Dilma do Socorro
Cunha-Neto, Edecio
J. A. Ramires, Felix
Bacal, Fernando
Pereira Nunes, Maria do Carmo
Martinelli Filho, Martino
Ibrahim Scanavacca, Maurício
Magalhães Saraiva, Roberto
Alves de Oliveira Júnior, Wilson
M. Lorga-Filho, Adalberto
de Jesus Benevides de Almeida Guimarães, Adriana
Lopes Latado Braga, Adriana
Sarmento de Oliveira, Adriana
V. L. Sarabanda, Alvaro
Yecê das Neves Pinto, Ana
Assis Lopes do Carmo, André
Schmidt, André
Costa, Andréa Rodrigues da
Ianni, Barbara Maria
Markman Filho, Brivaldo
Eduardo Rochitte, Carlos
Thé Macedo, Carolina
Mady, Charles
Chevillard, Christophe
Bittencourt das Virgens, Cláudio Marcelo
Nery de Castro, Cleudson
De Paoli de Carvalho Britto, Constança Felícia
Pisani, Cristiano
do Carmo Rassi, Daniela
C. Sobral Filho, Dario
Rodrigues Almeida, Dirceu
A. Bocchi, Edimar
T. Mesquita, Evandro
de Souza Nogueira Sardinha Mendes, Fernanda
Pereira, Francisca Tatiana
Sperandio da Silva, Gilberto Marcelo
de Lima Peixoto, Giselle
Glotz de Lima, Gustavo
H. Veloso, Henrique
Turin Moreira, Henrique
Bellotti Lopes, Hugo
Masciarelli Francisco Pinto, Ibraim
Pinto Dias, João Carlos
Bemfica, João Marcos
Silva-Nunes, João Paulo
Soares Barreto-Filho, José Augusto
Kerr Saraiva, José Francisco
Lannes-Vieira, Joseli
Menezes Oliveira, Joselina Luzia
V. Armaganijan, Luciana
Martins, Luiz Cláudio
C. Sangenis, Luiz Henrique
Barbosa, Marco Paulo
Almeida-Santos, Marcos Antônio
Simões, Marcos Vinicius
Shikanai-Yasuda, Maria Aparecida
Vieira Moreira, Maria da Consolação
Higuchi, Maria de Lourdes
Costa Monteiro, Maria Rita de Cássia
Felix Mediano, Mauro Felippe
Maia Lima, Mayara
T. Oliveira, Maykon
Moreira Dias Romano , Minna
Nitz, Nadjar
de Tarso Jorge Medeiros, Paulo
Vieira Alves, Renato
Alkmim Teixeira, Ricardo
Coury Pedrosa, Roberto
Aras, Roque
Morais Torres, Rosália
dos Santos Povoa, Rui Manoel
Rassi, Sérgio Gabriel
Salles Xavier, Sérgio
Marinho Martins Alves , Silvia
B. N. Tavares, Suelene
Lima Palmeira, Swamy
da Silva Junior, Telêmaco Luiz
da Rocha Rodrigues, Thiago
Madrini Junior, Vagner
Maia da Costa , Veruska
Dutra, Walderez
This guideline aimed to update the concepts and formulate the standards of conduct and scientific evidence that support them, regarding the diagnosis and treatment of the Cardiomyopathy of Chagas disease, with special emphasis on the rationality base that supported it.nbsp;
Chagas disease in the 21st century maintains an epidemiological pattern of endemicity in 21 Latin American countries. Researchers and managers from endemic and non-endemic countries point to the need to adopt comprehensive public health policies to effectively control the interhuman transmission of T. cruzi infection, and to obtain an optimized level of care for already infected individuals, focusing on diagnostic and therapeutic opportunistic opportunities.
nbsp;
Pathogenic and pathophysiological mechanisms of the Cardiomyopathy of Chagas disease were revisited after in-depth updating and the notion that necrosis and fibrosis are stimulated by tissue parasitic persistence and adverse immune reaction, as fundamental mechanisms, assisted by autonomic and microvascular disorders, was well established. Some of them have recently formed potential targets of therapies.nbsp;
The natural history of the acute and chronic phases was reviewed, with enhancement for oral transmission, indeterminate form and chronic syndromes. Recent meta-analyses of observational studies have estimated the risk of evolution from acute and indeterminate forms and mortality after chronic cardiomyopathy. Therapeutic approaches applicable to individuals with Indeterminate form of Chagas disease were specifically addressed. All methods to detect structural and/or functional alterations with various cardiac imaging techniques were also reviewed, with recommendations for use in various clinical scenarios. Mortality risk stratification based on the Rassi score, with recent studies of its application, was complemented by methods that detect myocardial fibrosis.nbsp;
The current methodology for etiological diagnosis and the consequent implications of trypanonomic treatment deserved a comprehensive and in-depth approach. Also the treatment of patients at risk or with heart failure, arrhythmias and thromboembolic events, based on pharmacological and complementary resources, received special attention. Additional chapters supported the conducts applicable to several special contexts, including t. cruzi/HIV co-infection, risk during surgeries, in pregnant women, in the reactivation of infection after heart transplantation, and others.nbsp; nbsp;nbsp;
Finally, two chapters of great social significance, addressing the structuring of specialized services to care for individuals with the Cardiomyopathy of Chagas disease, and reviewing the concepts of severe heart disease and its medical-labor implications completed this guideline.
Esta diretriz teve como objetivo principal atualizar os conceitos e formular as normas de conduta e evidências científicas que as suportam, quanto ao diagnóstico e tratamento da CDC, com especial ênfase na base de racionalidade que a embasou.
A DC no século XXI mantém padrão epidemiológico de endemicidade em 21 países da América Latina. Investigadores e gestores de países endêmicos e não endêmicos indigitam a necessidade de se adotarem políticas abrangentes, de saúde pública, para controle eficaz da transmissão inter-humanos da infecção pelo T. cruzi, e obter-se nível otimizado de atendimento aos indivíduos já infectados, com foco em oportunização diagnóstica e terapêutica.
Mecanismos patogênicos e fisiopatológicos da CDC foram revisitados após atualização aprofundada e ficou bem consolidada a noção de que necrose e fibrose sejam estimuladas pela persistência parasitária tissular e reação imune adversa, como mecanismos fundamentais, coadjuvados por distúrbios autonômicos e microvasculares. Alguns deles recentemente constituíram alvos potenciais de terapêuticas.
A história natural das fases aguda e crônica foi revista, com realce para a transmissão oral, a forma indeterminada e as síndromes crônicas. Metanálises recentes de estudos observacionais estimaram o risco de evolução a partir das formas aguda e indeterminada e de mortalidade após instalação da cardiomiopatia crônica. Condutas terapêuticas aplicáveis aos indivíduos com a FIDC foram abordadas especificamente. Todos os métodos para detectar alterações estruturais e/ou funcionais com variadas técnicas de imageamento cardíaco também foram revisados, com recomendações de uso nos vários cenários clínicos. Estratificação de risco de mortalidade fundamentada no escore de Rassi, com estudos recentes de sua aplicação, foi complementada por métodos que detectam fibrose miocárdica.
A metodologia atual para diagnóstico etiológico e as consequentes implicações do tratamento tripanossomicida mereceram enfoque abrangente e aprofundado. Também o tratamento de pacientes em risco ou com insuficiência cardíaca, arritmias e eventos tromboembólicos, baseado em recursos farmacológicos e complementares, recebeu especial atenção. Capítulos suplementares subsidiaram as condutas aplicáveis a diversos contextos especiais, entre eles o da co-infecção por T. cruzi/HIV, risco durante cirurgias, em grávidas, na reativação da infecção após transplante cardíacos, e outros.nbsp;nbsp;nbsp;
Por fim, dois capítulos de grande significado social, abordando a estruturação de serviços especializados para atendimento aos indivíduos com a CDC, e revisando os conceitos de cardiopatia grave e suas implicações médico-trabalhistas completaram esta diretriz.nbsp;
11.
Paul Bouts and the Short Life of Psychognomy in Brazil
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Resumo Paul Bouts (1900–1999) foi um pedagogo e padre católico belga que criou a psicognomia, um sistema de análise caracterológica que combinava elementos da frenologia, tipologia, medições craniofaciais, fisionomia, grafologia etc. Suas teorias influenciaram acadêmicos, religiosos, políticos e militares brasileiros. Bouts tinha uma saúde frágil, e não há evidências de que tenha estado no Brasil. Seu livro mais famoso, Psicognomia, foi publicado no país em 1943 com aval da censura eclesiástica e com apêndices especiais. A doutrina levou, ainda, à criação, em 1949, de um instituto privado de divulgação e estudos de psicognomia com sede no Rio de Janeiro, que publicou dois volumes de um tratado sobre o tema e permaneceu ativo até o início da década de 1960, quando o interesse pelo assunto rapidamente desapareceu na sociedade. 1900–1999 19001999 1900 1999 (1900–1999 frenologia tipologia craniofaciais fisionomia etc acadêmicos religiosos brasileiros frágil Brasil famoso Psicognomia 194 especiais levou ainda criação 1949 Janeiro 1960 sociedade 1900–199 1900199 190 199 (1900–199 19 196 1900–19 190019 (1900–19 1 1900–1 19001 (1900–1 1900– (1900– (1900 (190 (19 (1 (
Abstract Paul Bouts (1900–1999) was a Belgian pedagogue, a Roman Catholic priest, and the founder of Psychognomy, which is a personality diagnostic system combining phrenology and several related practices – typology, craniofacial measurements, physiognomy, graphology etc. Bouts had a fragile health; therefore, it is unlikely that he travelled to Brazil. Despite this, his most famous book, rich in conservative and religious thoughts, was translated to Portuguese and published with ecclesiastic support in 1943, and the doctrine acquired good reputation among Brazilian members of the clergy, politicians, teachers, and military personnel. Lay scholars and medical doctors founded a Brazilian institute devoted to the study and diffusion of psychognomy in 1949. They published two volumes of a psychognomy treatise, and the institute was active until the early 1960s, when social interest in the subject rapidly vanished. 1900–1999 19001999 1900 1999 (1900–1999 pedagogue priest Psychognomy typology measurements physiognomy etc health therefore Brazil this book thoughts 1943 clergy politicians teachers personnel 1949 treatise 1960s s vanished 1900–199 1900199 190 199 (1900–199 194 1900–19 190019 19 (1900–19 1900–1 19001 1 (1900–1 1900– (1900– (1900 (190 (19 (1 (
12.
De Verfall e Verkümmerung a Katastrophe: a modernidade em Walter Benjamin
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Resumo O objetivo desse artigo é retomar uma série de conceitos-chave e noções de Walter Benjamin - na edição alemã de seus escritos - a partir da hipótese de que, através de seu preceito de den Pessimismus organisieren, há uma passagem do enfoque da modernidade como Verfall e Verkümmerung de capacidades humanas ao seu enfoque como Katastrophe da humanidade e do mundo. Essa passagem, certamente vinculada aos acontecimentos históricos que levam à morte do autor em 1940, inicia-se com as discussões sobre Vermögen e Wahrnehmung e conclui-se com as teses sobre Begriff der Geschichte. E entre o início e a conclusão estão reflexões pertinentes à abordagem de “Untergang des Subjekts” (ADORNO 2011: 241) e de Massenproduktion em geral e na arte: Erfahrung, Phantasievorstellung, Potenz, Erinnern, Gedächtnis, Erzählen, Lyrik e Aura. Sendo assim, é necessário investigar a passagem de Verfall e Verkümmerung a Katastrophe através de quatro ensaios sobre Sprache, dos principais escritos pertinentes a Untergang des Subjekts e Massenproduktion (Passagen-Werk, “Der Erzähler”, Charles Baudelaire e ensaios sobre a obra de arte e a fotografia) e das teses de “Über den Begriff der Geschichte”. Cabe, por fim, considerar que, em todo esse processo, Benjamin não deixa de tratar de Hilfsmittel para Vertiefung der Apperzeption.
Abstract The aim of this article is to discuss a series of key concepts and notions of Walter Benjamin - in the German edition of his writings - taking as starting point the hypothesis that, in the context of his precept of den Pessimismus organisieren, there is a shift from a focus on modernity as Verfall and Verkümmerung of human capacities towards Katastrophe of humanity and the world. This shift, certainly linked to the historical events that led to the author's death in 1940, begins with discussions on Vermögen and Wahrnehmung and concludes with the theses on Begriff der Geschichte. And between the beginning and the conclusion are reflections pertinent to the approach of “Untergang des Subjekts” (ADORNO 2011: 241) and of Massenproduktion in general and in art: Erfahrung, Phantasievorstellung, Potenz, Erinnern, Gedächtnis, Erzählen, Lyrik and Aura. Therefore, it is necessary to investigate the shift from Verfall and Verkümmerung to Katastrophe through four essays on Sprache, the main writings relevant to Untergang des Subjekts and Massenproduktion (Passagen-Werk, “Der Erzähler”, Charles Baudelaire and essays on the work of art and photography) and the theses of “Über den Begriff der Geschichte”. Finally, it is worth considering that, throughout this process, Benjamin does not forget dealing with Hilfsmittel for Vertiefung der Apperzeption.
13.
Complementarity between parents for earliness and grain yield in soybean
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Bezerra, André Ricardo Gomes
; Sediyama, Tuneo
; Silva, Felipe Lopes da
; Cruz, Cosme Damião
; Silva, Amilton Ferreira da
; Silva, Francisco Charles dos Santos
; Rosa, Daniele Piano
.
Resumo O objetivo deste trabalho foi determinar a capacidade geral e a específica de combinação (CGC e CEC, respectivamente) de seis genitores de soja (Glycine max), para identificar aqueles que são promissores e suas melhores combinações para o desenvolvimento de linhagens superiores quanto à precocidade e à produção de grãos, bem como à melhor época de avaliação. Seis genitores e seus 15 híbridos foram avaliados em blocos ao acaso, durante o inverno de 2014 e o verão de 2015/2016, em casa de vegetação. Os dados obtidos para número de dias para florescimento, ciclo e produção foram analisados pelo método 2 de Griffing, modelo 1. Resultados contrastantes foram obtidos para as duas épocas, com ciclo mais curto e maior produtividade no verão. A maior CGC quanto ao ciclo é observada nos progenitores 'MSOY6101' e 'MSOY9144RR', com sinal negativo e positivo, respectivamente. 'TMG123RR' apresenta a maior CGC quanto à produção de grãos. A maior CEC quanto ao número de dias para o florescimento e ao ciclo está associada aos cruzamentos 'SYN9078RR' x 'MSOY9144RR' e 'TMG123RR' x 'MSOY9144RR', respectivamente. No entanto, a maior CEC quanto à produção de grãos é observada em 'MSOY6101' x 'MSOY9144RR', com valor positivo, e 'TMG801' x 'MSOY9144RR', com valor negativo, durante o verão.
Abstract The objective of this work was to determine the general and specific combining ability (GCA and SCA, respectively) of six soybean (Glycine max) parents, in order to identify the promising ones and their best combinations for the development of superior lines for earliness and grain yield, as well as the best evaluation season. Six parents and their 15 hybrids were evaluated in a randomized complete block design, during the 2014 winter and 2015/2016 summer, in a greenhouse. The data obtained for number of days to flowering, cycle, and grain yield were analyzed by Griffing’s method 2, model 1. Contrasting results were obtained for the two seasons, with a shorter cycle and a higher yield in the summer. The highest GCA for cycle is observed for the 'MSOY6101' and 'MSOY9144RR' parents, with negative and positive signs, respectively. 'TMG123RR' shows the highest GCA for grain yield. The highest SCA for days to flowering and cycle is associated with the 'SYN9078RR' × 'MSOY9144RR' and 'TMG123RR' × 'MSOY9144RR' crosses, respectively. However, the highest SCA for grain yield is observed for 'MSOY6101' × 'MSOY9144RR', with a positive value, and for 'TMG801' × 'MSOY9144RR', with a negative value, during the summer.
14.
Dried distillers grains with solubles in diets during late gestation affects behavior and maintains the performance of sows
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Corassa, Anderson
; Silva, Lariza Luana da
; Souza, Caroline
; Rodrigues, Luiz José
; Lemes, Geriel Araujo
; Kiefer, Charles
; Sbardella, Maicon
; Araújo, Cláudio Vieira de
; Rothmund, Vivian Luana
; Oliveira, André Soares de
.
ABSTRACT We examined the effect of dried distillers grains with solubles (DDGS) in diets for late gestating sows on sow and litter performance, colostrum chemical composition, and sow behavior. Sixty gestating sows of 3.77±1.65 parity were divided into three groups of 20 animals, in a randomized block design with 0 (corn-soybean meal diet), 150, or 300 g kg−1 DDGS from 84 days of gestation until farrowing. Sows fed 300 g kg−1 DDGS presented a lower frequency of standing position and eating activity. The lying lateral position was more frequent in the first 40 min post-feeding for sows fed the highest DDGS level. There was no effect of diets on sow and litter performance; however, DDGS inclusion tended to increase lactation feed intake. Inclusion of DDGS was inclined to produce more lactose and less protein in colostrum, but did not affect colostrum fat, total solids, and ash contents. Inclusion of up to 300 g kg−1 DDGS in the diet of late gestation sows does not change sow and litter performance and colostrum composition compared with corn-soybean meal diets, but it favored animal welfare.
15.
Perfil Clínico, Laboratorial e de Métodos de Imagem na Amiloidose Sistêmica em um Centro de Referência Cardiológico Brasileiro
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Fernandes, Fábio
; Alencar Neto, Aristóteles Comte de
; Bueno, Bruno Vaz Kerges
; Cafezeiro, Caio Rebouças Fonseca
; Rissato, João Henrique
; Szor, Roberta Shcolnik
; Carvalho, Mariana Lombardi Peres de
; Mathias Júnior, Wilson
; Lino, Angelina Maria Martins
; Castelli, Jussara Bianchi
; Souza, Evandro de Oliveira
; Ramires, Félix José Alvarez
; Hotta, Viviane Tiemi
; Soares Júnior, José
; Tavares, Caio de Assis Moura
; Krieger, José Eduardo
; Rochitte, Carlos Eduardo
; Dabarian, André
; Hajjar, Ludhmila Abrahão
; Kalil Filho, Roberto
; Mady, Charles
.
Resumo Fundamento Amiloidose sistêmica é uma doença com manifestações clínicas diversas. O diagnóstico envolve suspeita clínica, aliada a métodos complementares. Objetivo Descrever o perfil clínico, laboratorial, eletrocardiográfico e de imagem no acometimento cardíaco da amiloidose sistêmica. Métodos Estudo de uma amostra de conveniência, analisando dados clínicos, laboratoriais, eletrocardiográficos, ecocardiográficos, medicina nuclear e ressonância magnética. Considerou-se significância estatística quando p < 0,05. Resultados Avaliaram-se 105 pacientes (com mediana de idade de 66 anos), sendo 62 homens, dos quais 83 indivíduos apresentavam amiloidose por transtirretina (ATTR) e 22 amiloidose por cadeia leve (AL). Na ATTR, 68,7% eram de caráter hereditário (ATTRh) e 31,3% do tipo selvagem (ATTRw). As mutações mais prevalentes foram Val142Ile (45,6%) e Val50Met (40,3%). O tempo de início dos sintomas ao diagnóstico foi 0,54 e 2,15 anos nas formas AL e ATTR (p < 0,001), respectivamente. O acometimento cardíaco foi observado em 77,9% dos ATTR e 90,9% dos AL. Observaram-se alterações de condução atrioventricular em 20% e intraventricular em 27,6% dos pacientes, sendo 33,7 % na ATTR e 4,5% das AL (p = 0,006). A forma ATTRw apresentou mais arritmias atriais que os ATTRh (61,5% x 22,8%; p = 0,001). Ao ecocardiograma a mediana da espessura do septo na ATTRw x ATTRh x AL foi de 15 mm x 12 mm x 11 mm (p = 0,193). Observou-se BNP elevado em 89,5% dos indivíduos (mediana 249 ng/mL, IQR 597,7) e elevação da troponina em 43,2%. Conclusão Foi possível caracterizar, em nosso meio, o acometimento cardíaco na amiloidose sistêmica, em seus diferentes subtipos, através da história clínica e dos métodos diagnósticos descritos.
Abstract Background Systemic amyloidosis is a disease with heterogeneous clinical manifestations. Diagnosis depends on clinical suspicion combined with specific complementary methods. Objective To describe the clinical, laboratory, electrocardiographic, and imaging profile in patients with systemic amyloidosis with cardiac involvement. Methods This study was conducted with a convenience sample, analyzing clinical, laboratory, electrocardiographic, echocardiographic, nuclear medicine, and magnetic resonance data. Statistical significance was set at p < 0.05. Results A total of 105 patients were evaluated (median age of 66 years), 62 of whom were male. Of all patients, 83 had transthyretin (ATTR) amyloidosis, and 22 had light chain (AL) amyloidosis. With respect to ATTR cases, 68.7% were the hereditary form (ATTRh), and 31.3% were wild type (ATTRw). The most prevalent mutations were Val142Ile (45.6%) and Val50Met (40.3%). Time from onset of symptoms to diagnosis was 0.54 and 2.15 years, in the AL and ATTR forms, respectively (p < 0.001). Cardiac involvement was observed in 77.9% of patients with ATTR and in 90.9% of those with AL. Alterations were observed in atrioventricular and intraventricular conduction in 20% and 27.6% of patients, respectively, with 33.7% in ATTR and 4.5% in AL (p = 0.006). In the ATTRw form, there were more atrial arrhythmias than in ATTRh (61.5% versus 22.8%; p = 0.001). On echocardiogram, median septum thickness in ATTRw, ATTRh, and AL was 15 mm, 12 mm, and 11 mm, respectively (p = 0.193). Elevated BNP was observed in 89.5% of patients (median 249, ICR 597.7), and elevated troponin was observed in 43.2%. Conclusion In this setting, it was possible to characterize cardiac involvement in systemic amyloidosis in its different subtypes by means of clinical history and the diagnostic methods described.
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