Abstract Objective To analyze risk factors (maternal, obstetric and demographic) associated with congenital syphilis and the clinical characteristics of the newborns. Method A cross-sectional study carried out in ten public maternity hospitals in Fortaleza, Ceará, Brazil that included cases of live births reported with congenital syphilis in 2015. Results 469 cases were analyzed; 199 (42.4 %) showed some sign or symptom suggestive of congenital syphilis; of these, 65 (32.7 %) were preterm, 87 (43.7 %) had low birth weight, 116 (58.3 %) had jaundice that required phototherapy, 13 (6.5 %) had hepatomegaly, 10 (5 %) had skin lesions, eight (4.0 %) had splenomegaly and one (0.5 %) had limb pseudoparalysis. Records of other clinical changes were identified in 36 (7.7 %) children. Children whose mothers were not treated or who received a drug other than penicillin and those whose mothers had a VDRL titer ≥ 1:16 at birth were 3.7 and 3.2 times more likely to be born with signs of congenital syphilis (p < 0.001- 95 % CI 2.41-5.58; p < 0.001 - 95 % CI 2.41-5.58) respectively. Conclusions The findings of this study draw attention to the importance of improving the quality of prenatal care and the development of studies aimed at finding alternative drugs for the treatment of syphilis in pregnant women and the prevention of congenital syphilis. maternal, maternal (maternal demographic newborns crosssectional cross sectional Fortaleza Ceará 2015 46 analyzed 19 42.4 424 42 4 (42. these 6 32.7 327 32 7 (32. preterm 8 43.7 437 43 (43. weight 11 58.3 583 58 3 (58. phototherapy 1 6.5 5 (6. hepatomegaly ( lesions 4.0 40 0 (4. 0.5 05 (0. pseudoparalysis 7.7 77 (7. children 16 1:1 37 3. 2 0001 001 9 2.415.58 241558 2.41 5.58 41 2.41-5.58 0.00 respectively 201 42. (42 32. (32 43. (43 58. (58 6. (6 4. (4 0. (0 7. (7 1: 000 00 415 2.415.5 24155 241 2.4 558 5.5 2.41-5.5 0.0 20 (3 2.415. 2415 24 2. 55 5. 2.41-5. 2.415 2.41-5 2.41-

Abstract This article aims to investigate the implications of grief among family members of COVID-19 victims; verify the prevalence of prolonged grief symptoms; and identify family members’ expectations regarding end-of-life care for their loved ones affected by COVID-19. Descriptive, cross-sectional research, with a quantitative-qualitative approach. Data collection was performed using an online questionnaire, guided by the PG-13 instrument. Descriptive and inferential statistics were applied. The results were presented descriptively and with the aid of tables. The study sample included 142 family members, mostly female, who presented emotional, physical, social, and financial implications as a result of grief. A prevalence of prolonged grief symptoms was observed in 11.4% of the mourners with more than six months and 29.6% of those with less than six months. Three thematic categories were identified: transparency in communicating the health situation, access to moments of farewell, and promotion of comfort in care actions. The symptoms of Prolonged Grief Disorder have a significant association with the degree of kinship. In final care, family members’ expectations were classified as: permission for a dignified farewell, effective communication, and promotion of comfort and care.

Resumo O objetivo deste artigo é investigar implicações do luto em familiares de vítimas da COVID-19; verificar a prevalência de sintomas de luto prolongado; identificar expectativas dos familiares acerca do cuidado em fim de vida de seus entes acometidos por COVID-19. Pesquisa descritiva, transversal, com abordagem quanti-qualitativa. Coleta de dados mediante questionário on-line, norteado pelo instrumento PG-13. Aplicou-se estatística descritiva e inferencial. Os resultados foram apresentados de forma descritiva e com auxílio de tabelas. Amostra de 142 familiares, maioria do sexo feminino, que apresentaram implicações emocionais, físicas, sociais e financeiras em decorrência do luto. Houve prevalência de sintomas de luto prolongado em 11,4% dos enlutados com mais de seis meses e 29.6% dos que tinham menos de seis meses. Foram identificadas três categorias temáticas: transparência na comunicação da situação de saúde, acesso a momentos de despedida e promoção de conforto nas ações de cuidado. Os sintomas de Transtorno de Luto Prolongado possuem associação significativa com o grau de parentesco. Nos cuidados finais as expectativas dos familiares foram classificadas em: permissão para despedida digna, comunicação efetiva e promoção de conforto e cuidado.

Abstract It aimed to analyze how professionals from an intersectoral service network develop care actions for adolescents with suicidal and self-injurious behaviors. This is a descriptive and exploratory study with a qualitative approach, carried out through notes in the field diary and semi-structured interviews with 22 professionals linked to social assistance, education and health services in a large municipality in northeastern Brazil. Data collection took place from August to September 2021. The speeches were subjected to content analysis in the inductive thematic modality, with support from the Nvivo 11 Pro software. Given this, two categories emerged: intersectoral network care strategies and weaknesses in care. Professionals perceive adolescents as subjects who need support for their psychological suffering. In this way, they develop, as the main care strategies, reception and prevention activities, on a punctual basis. However, the care network appears to be insufficient, due to the scarcity of child and youth policies and specialized services, in addition to difficulties in practicing intersectorality. It is concluded that the care offered to adolescents is fragile and requires the strengthening of transversal public policies, expansion of primary/specialized services and intersectoral work.

Resumo Objetivou-se analisar como os profissionais de uma rede de serviços intersetoriais desenvolvem ações de cuidado aos adolescentes com comportamentos suicidas e autolesivos. Trata-se de um estudo descritivo e exploratório de abordagem qualitativa, realizado através de anotações no diário de campo e entrevistas semiestruturadas com 22 profissionais vinculados a serviços da assistência social, educação e saúde de um município de grande porte do nordeste brasileiro. A coleta de dados ocorreu no período de agosto a setembro de 2021. Os discursos foram submetidos à análise de conteúdo na modalidade temática indutiva, com suporte do software Nvivo 11 Pro. Diante disso, duas categorias emergiram: estratégias de cuidado da rede intersetorial e fragilidades no cuidado. Os profissionais percebem os adolescentes como sujeitos que necessitam de suporte para o sofrimento psíquico apresentado. Deste modo desenvolvem, como principais estratégias de cuidado, o acolhimento e as atividades de prevenção, estas de modo pontual. Contudo, a rede de cuidados mostra-se insuficiente, devido à escassez de políticas infantojuvenis e serviços especializados, além de dificuldades na prática da intersetorialidade. Conclui-se que o cuidado ofertado aos adolescentes é fragilizado e necessita do fortalecimento de políticas públicas transversais, ampliação dos serviços primários/especializados e do trabalho intersetorial.

Abstract Violence against women is defined as any act resulting from gender relations that cause death or physical, sexual, psychological, property and moral harm. Comprehensive care requires professionals understanding the support network to guide and refer women victims of violence to services and to value complaints/anxieties. The objective of this study was to identify the scientific production of comprehensive care for women victims of violence. This is an integrative literature review. Data collection was performed via a paired and independent search by two researchers in the Scopus, PubMed, CINAHL, Web of Science, LILACS, BDENF and SciELO databases between January and February 2023. After applying the eligibility criteria and descriptors in health sciences and medical subject headings, ten articles were retrieved. IRAMUTEQ software was used for data analyses. There are great challenges in implementing comprehensive care, and violence against women, as a serious social problem, demands health, education, social assistance and public security policies. The comprehensive actions taken in the care of women victims of violence demonstrate a strong link with the practices of reception and humanization, in addition to an interdisciplinary and intersectoral scope.

Resumo A violência direcionada à mulher é definida como todo ato resultante das relações de gênero que cause morte, dano físico, sexual, psicológico, patrimonial e moral. O cuidado integral possibilita que o profissional conheça a rede de apoio, a fim de orientá-las e encaminhá-las aos serviços, e valorize queixas/anseios. Objetivou-se identificar a produção científica acerca do cuidado integral às mulheres vítimas de violência. Trata-se de uma revisão integrativa da literatura. A coleta de dados ocorreu com busca pareada e independente de duas pesquisadoras, nos bancos Scopus, PubMed, CINAHL, Web of Science, LILACS, BDENF e SciELO, no período de janeiro e fevereiro de 2023. Foram utilizados critérios de elegibilidade, Descritores em Ciências da Saúde e Medical Subject Headings, totalizando dez artigos. Na análise dos dados, utilizou-se o software Iramuteq. Verificou-se grandes desafios para o cuidado integral, e que a violência contra a mulher, por ser uma problemática social grave, demanda políticas de saúde, educação, assistência social e segurança pública. Conclui-se que as ações integrais no cuidado à mulher vítima de violência demonstram forte vínculo com as práticas de acolhimento, humanização, além de perpassarem o âmbito interdisciplinar e intersetorial.

Stemodin (1) is a diterpene produced by Stemodia maritima L. (Scrophulariaceae) and shows antiviral and tumor cell proliferation inhibitory activities. Chemical modifications of 1 were performed to produce the known stemodinone (2), two new stemodinone oximes, Z (3) and E (4), and seven new oxime esters derivatives (5, 6, 7, 8, 9, 10, and 11). All derivatives were evaluated for their cytotoxic activity in HL60 (promyelocytic leukemia), SNB-19 (astrocytoma), HCT-116 (colon carcinoma), and PC3 (prostate) human cancer cell lines, and L929 (healthy murine cells). Oximes 3 and 4 showed lower cytotoxic values than 1 against all cancer cell lines tested. However, esters 9 and 10 exhibited cell growth inhibition percentages higher than 1 against PC3, SNB-19, and HCT-116 cancer cell lines, ranging from 62.96 to 94.27%. Many of these values exceed that presented by doxorubicin (66.05-86.87%). All compounds showed no cytotoxic effect on healthy cells at the tested concentration of 25 µg mL-1. (1 L Scrophulariaceae (Scrophulariaceae activities 2, 2 , (2) oximes (3 4, (4) 5, 5 (5 6 7 8 11. 11 . 11) HL HL6 promyelocytic leukemia, leukemia leukemia) SNB19 SNB 19 SNB-1 astrocytoma, astrocytoma (astrocytoma) HCT116 HCT 116 HCT-11 colon carcinoma, carcinoma carcinoma) PC prostate (prostate L92 cells. cells) However SNB19, 19, 6296 62 96 62.9 9427 94 27 94.27% 66.0586.87%. 66058687 66.05 86.87% 66 05 86 87 (66.05-86.87%) mL1. mL1 mL 1. mL-1 ( (2 (4 SNB1 SNB- (astrocytoma HCT11 HCT-1 L9 629 62. 942 94.27 0586 66.0586.87% 6605868 6605 66.0 8687 86.87 0 (66.05-86.87% mL- HCT1 HCT- 94.2 058 66.0586.87 660586 660 66. 868 86.8 (66.05-86.87 94. 66.0586.8 66058 86. (66.05-86.8 66.0586. (66.05-86. 66.0586 (66.05-86 66.058 (66.05-8 (66.05- (66.05 (66.0 (66. (66 (6

Abstract Objectives Our study aimed to verify the evidence of auditory training employed in the audiological treatment of tinnitus in adults and older adults. Methods Scoping review based on a search for articles in journals available in MEDLINE (PubMed), Embase (Elsevier), LILACS (BVS), and Cochrane Library. Titles and abstracts of the retrieved articles were assessed by peers, following the eligibility criteria; they were afterward read in full text, and the references were hand searched in the results found. Studies’ level of evidence was classified into very high (Level A+), high (Level A), moderate (Level B), limited (Level C), low (Level D), or very low (Level D−) based on the Critically Appraised Topics. Results 2160 records were identified in the searching stage and 15 studies were eligible for data extraction. Study design, sample characterization, auditory training tasks, sound stimuli, outcome measures, and results were extracted. Frequency discrimination training was the most frequent strategy, followed by auditory attentional skills training and multisensory training. Almost all studies with daily auditory training sessions reported significant benefits demonstrated in at least one outcome measure. Studies that used auditory discrimination training and attentional auditory skill stimulation to treat tinnitus obtained quality evidence levels ranging from limited to high (C‒A) and studies that applied multisensory training or attentional training combined with counseling and passive listening in tinnitus patients reached a high-quality evidence level (A). Conclusion Recent studies had higher levels of evidence and considered attentional factors and multisensory pathways in auditory training strategies. PubMed, PubMed , (PubMed) Elsevier, Elsevier (Elsevier) BVS, BVS (BVS) Library peers criteria text found Level A+, A A+ A+) A, A) B, B B) C, C C) D, D D) D− Topics 216 1 extraction design characterization tasks stimuli measures extracted strategy measure C‒A CA (C‒A highquality A. . (A) strategies (PubMed (Elsevier (BVS 21 (A 2

Resumo Este artigo aborda o capitalismo exportador de commodities na América Latina no século XXI, tendo como cerne as relações de poder entre empresas e agentes públicos na gestão da infraestrutura ferroviária brasileira, abordando o caso da Malha Regional Sudeste (MRS), sob gestão da concessionária MRS Logística S/A. Fundamenta-se na literatura marxista sobre a produção capitalista do espaço e as infraestruturas. Examina publicações oficiais dos órgãos governamentais competentes e da empresa, trazendo uma perspectiva enraizada em um ambiente diretamente impactado pela atuação empresarial. Expõe circunstâncias sob as quais está a MRS e discute artifícios e práticas da empresa para a legitimação do seu poder sobre os territórios onde atua, utilizando-se de tecnologias políticas, jurídicas, econômicas e socioculturais próprias da governamentalidade neoliberal. XXI brasileira MRS, , (MRS) SA S A S/A Fundamentase Fundamenta se infraestruturas empresarial atua utilizandose utilizando políticas jurídicas neoliberal (MRS

Abstract This article addresses commodity export capitalism in Latin America in the 21st century, having as its core the power relations between companies and public agents in the management of Brazilian rail infrastructure, addressing the case of the Malha Regional Sudeste (MRS), under the management of the concessionaire MRS Logística S/A. It is based on the Marxist literature on the capitalist production of space and infrastructure. It examines official publications from the competent government agencies and the company and brings a perspective rooted in an environment directly impacted by business activities. It exposes the circumstances under which MRS finds itself and discusses the company’s devices and practices to legitimize its power over the territories where it operates, using political, legal, economic and sociocultural technologies typical of neoliberal governmentality. st century infrastructure MRS, , (MRS) SA S A S/A activities companys s operates political legal governmentality (MRS

RESUMO: Objetivo: identificar as alterações cognitivas e funcionais mais frequentes em pessoas idosas após a fase aguda da COVID-19. Método: revisão integrativa da literatura com busca de artigos nas bases de dados LILACS, MEDLINE, PubMed e Scopus, entre junho e julho de 2024. A seleção foi realizada independentemente por dois revisores e validada por um terceiro revisor. Foram incluídos os estudos originais primários que envolveram participantes com maioria ou mediana de idade superior a 60 anos, com alterações cognitivas e funcionais pós-COVID-19. Resultados: observou-se a heterogeneidade nas amostras, com vasto espectro de características clínicas, sendo as mais prevalentes: dispneia, fadiga, alterações no padrão de sono e déficit cognitivo. Conclusão: os resultados contribuem para uma melhor avaliação e conduta. Apontam a necessidade de criação de protocolos específicos de atendimento às pessoas idosas com síndrome pós-COVID-19 e desenvolvimento de intervenções mais adequadas e direcionadas à prevenção, redução ou minimização dos sintomas persistentes. RESUMO Objetivo COVID19. COVID19 COVID 19. 19 COVID-19 Método LILACS MEDLINE Scopus 2024 revisor 6 anos pósCOVID19. pósCOVID19 pósCOVID pós Resultados observouse observou se amostras clínicas prevalentes dispneia fadiga cognitivo Conclusão conduta pós-COVID-1 prevenção persistentes COVID1 1 COVID-1 202 pósCOVID1 pós-COVID- COVID- 20 pós-COVID 2

ABSTRACT Objective: To identify the most frequent cognitive and functional changes in elderly people after the acute phase of COVID-19. Method: Integrative literature review with a search for articles in the LILACS, MEDLINE, PubMed, and Scopus databases, between June and July 2024. The selection was conducted independently by two reviewers and validated by a third reviewer. Original primary studies were included that involved participants with a majority or median age over 60 years, with post-COVID-19 cognitive and functional changes. Results: Heterogeneity was observed in the samples, with a wide range of clinical characteristics, the most prevalent being: dyspnea, fatigue, changes in sleep patterns, and cognitive deficit. Conclusion: The results contribute to a better assessment and conduct. They point to the need to create specific care protocols for elderly people with post-COVID-19 syndrome and to develop more appropriate and targeted interventions for the prevention, reduction, or minimization of persistent symptoms. Objective COVID19. COVID19 COVID 19. 19 COVID-19 Method LILACS MEDLINE PubMed databases 2024 reviewer 6 years postCOVID19 postCOVID post post-COVID-1 Results samples characteristics being dyspnea fatigue patterns deficit Conclusion conduct prevention reduction symptoms COVID1 1 COVID-1 202 postCOVID1 post-COVID- COVID- 20 post-COVID 2

RESUMEN Objetivo: identificar los cambios cognitivos y funcionales más frecuentes en personas mayores después de la fase aguda de COVID-19. Método: revisión integrativa de la literatura con búsqueda de artículos en las bases de datos LILACS, MEDLINE, PubMed y Scopus, entre junio y julio de 2024. La selección fue realizada independientemente por dos revisores y validada por un tercer revisor. Se incluyeron los estudios originales primarios que involucraron participantes con mayoría o mediana de edad superior a 60 años, con alteraciones cognitivas y funcionales post-COVID-19. Resultados: se observó la heterogeneidad en las muestras, con un amplio espectro de características clínicas, siendo las más prevalentes: disnea, fatiga, alteraciones en el patrón de sueño y déficit cognitivo. Conclusión: los resultados contribuyen a una mejor evaluación y conducta. Señalan la necesidad de crear protocolos específicos de atención para las personas mayores con síndrome post-COVID-19 y desarrollar intervenciones más adecuadas y dirigidas a la prevención, reducción o minimización de los síntomas persistentes. Objetivo COVID19. COVID19 COVID 19. 19 COVID-19 Método LILACS MEDLINE Scopus 2024 revisor 6 años postCOVID19. postCOVID19 postCOVID post Resultados muestras clínicas prevalentes disnea fatiga cognitivo Conclusión conducta post-COVID-1 prevención persistentes COVID1 1 COVID-1 202 postCOVID1 post-COVID- COVID- 20 post-COVID 2

Resumo Objetivo Identificar, analisar e caracterizar as ocorrências cometidas por profissionais de enfermagem acolhidas pela Comissão de Ética de Enfermagem. Métodos Revisão integrativa conduzida conforme a metodologia definida pelo Manual for Evidence Synthesis do Joanna Briggs Institute e registrada na plataforma Open Science Framework. Bases de dados pesquisadas: Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medical Literature Analysis and Retrieval System on-line (MEDLINE via PubMed®), Web of Science, SciVerse Scopus (SCOPUS), Literatura LatinoAmericana e do Caribe em Ciências da Saúde (LILACS) e Base de dados de Enfermagem (BDENF) via Biblioteca Virtual em Saúde (BVS). Incluídos estudos publicados integralmente em português, inglês ou espanhol de 2018 a 2023. Gerenciamento dos dados realizado com o Rayyan®. Resultados Verificado um crescente interesse pelas infrações em denúncias imputadas a profissionais de Enfermagem acolhidas pela Comissão de Ética de Enfermagem no contexto profissional da área da saúde, expressas pelas publicações predominantes nos últimos cinco anos. Conclusão Profissionais de nível médio foram os mais denunciados, com maior participação de Auxiliares de Enfermagem. Negligência e Exercício Ilegal da Profissão foram os tipos penais de infração ética com maior incidência. As categorias dos denunciantes de infração ética foram as Comissões de Ética de Enfermagem, seguidas pelos familiares das vítimas, Conselhos Regionais de Enfermagem, vítimas e enfermeiros como denunciantes principais. Advertência Verbal foi o tipo de penalidade aplicada com maior prevalência. Identificar Framework pesquisadas CINAHL, CINAHL , (CINAHL) online on line MEDLINE PubMed®, PubMed PubMed® PubMed®) SCOPUS, SCOPUS (SCOPUS) LILACS (LILACS BDENF (BDENF BVS. BVS . (BVS) português 201 2023 Rayyan Rayyan® saúde anos denunciados incidência principais prevalência (CINAHL (SCOPUS (BVS 20 202 2

Abstract Objective To identify, analyze, and characterize the incidents committed by nursing professionals received by the Nursing Ethics Committee. Methods Integrative review conducted according to the methodology defined by the Manual for Evidence Synthesis from the Joanna Briggs Institute and registered on the Open Science Framework platform. Databases searched: Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medical Literature Analysis and Retrieval System Online (MEDLINE via PubMed®), Web of Science, SciVerse Scopus (SCOPUS), Latin American and Caribbean Literature in Health Sciences (LILACS) and Nursing Database (BDENF) via Virtual Health Library (VHL). Studies entirely published in Portuguese, English, or Spanish (2018-2023) were included. Data management was carried out with Rayyan®. Results A growing interest in infractions in complaints attributed to nursing professionals, which were accepted by the Nursing Ethics Committee in the professional context of the health area and expressed by predominant publications in the last five years, was verified. Conclusion Mid-level professionals were the most reported, with a greater participation of Nursing Assistants. Negligence and Illegal Exercise of Profession were the criminal types of ethical infractions with the highest incidence. Nursing Ethics Committees, followed by victims’ families, Regional Nursing Councils, victims, and nurses were the main categories of complainants of ethical violations. Verbal Warning was the most prevalent type of penalty applied. identify analyze platform searched CINAHL, CINAHL , (CINAHL) MEDLINE PubMed®, PubMed PubMed® PubMed®) SCOPUS, SCOPUS (SCOPUS) LILACS (LILACS BDENF (BDENF VHL. VHL . (VHL) Portuguese English 20182023 2018 2023 (2018-2023 included Rayyan Rayyan® years verified Midlevel Mid level reported Assistants incidence Committees victims families Councils violations applied (CINAHL (SCOPUS (VHL 2018202 201 202 (2018-202 201820 20 (2018-20 20182 2 (2018-2 (2018- (2018 (201 (20 (2 (

Resumen Objetivo Identificar, analizar y caracterizar infracciones cometidas por profesionales de enfermería admitidas por la Comisión de Ética de Enfermería. Métodos Revisión integradora llevada a cabo de acuerdo con la metodología establecida por el Manual for Evidence Synthesis del Joanna Briggs Institute y registrada en la plataforma Open Science Framework. Búsqueda en las siguientes bases de datos: Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medical Literature Analysis and Retrieval System on-line (MEDLINE vía PubMed®), Web of Science, SciVerse Scopus (SCOPUS), Literatura Latinoamericana y del Caribe en Ciencias de la Salud (LILACS) y Base de Datos de Enfermería (BDENF) a través de la Biblioteca Virtual en Salud (BVS). Se incluyeron estudios publicados con texto completo en portugués, inglés o español de 2018 a 2023. La gestión de los datos se realizó con Rayyan®.. Resultados Se verificó un creciente interés por las infracciones en denuncias imputadas a profesionales de enfermería admitidas por la Comisión de Ética de Enfermería en el contexto profesional del área de la salud, demostrado mediante las publicaciones predominantes en los últimos cinco años. Conclusión Los profesionales de nivel medio fueron los más denunciados, con una mayor participación de auxiliares de enfermería. Los tipos penales de infracción ética con mayor incidencia fueron negligencia y ejercicio ilegal de la profesión. Las categorías de los denunciantes de infracciones éticas fueron las Comisiones de Ética de Enfermería, seguidas de los familiares de las víctimas, Consejos Regionales de Enfermería, víctimas y enfermeros como denunciantes principales. La advertencia verbal fue el tipo de penalidad aplicada con mayor prevalencia. Identificar Framework CINAHL, CINAHL , (CINAHL) online on line MEDLINE PubMed®, PubMed PubMed® PubMed®) SCOPUS, SCOPUS (SCOPUS) LILACS (LILACS BDENF (BDENF BVS. BVS . (BVS) portugués 201 2023 Rayyan Rayyan®. salud años denunciados profesión principales prevalencia (CINAHL (SCOPUS (BVS 20 202 Rayyan® 2

ABSTRACT Objective: To evaluate the association between subclinical hypothyroidism and hepatic steatosis and fibrosis using the noninvasive diagnostic methods transient hepatic elastography (TE) and controlled attenuation parameter (CAP) in patients with subclinical hypothyroidism. Subjects and methods: This was a cross-sectional study including women with confirmed spontaneous subclinical hypothyroidism and an age- and body mass index (BMI)-matched control group without thyroid disease or circulating antithyroperoxidase (anti-TPO) antibodies. Exclusion criteria were age > 65 years, thyroid-stimulating hormone (TSH) > 10.0 mIUI/L, BMI ≥ 35 kg/m2, diabetes, or other chronic liver diseases. Liver stiffness was classified according to TE values (in kPa) and ranged from absence of fibrosis (F0) to advanced fibrosis (F3). Hepatic steatosis was classified according to CAP values (in dB/m) and ranged from low-grade (S1) to advanced (S3) steatosis. Results: Of 68 women enrolled, 27 were included in the subclinical hypothyroidism group and 41 in the control group. Advanced steatosis (S3) was more frequent in the subclinical hypothyroidism group (25.9% versus 7.3%, respectively, p = 0.034). Circulating anti-TPO was an independent factor associated with advanced steatosis (odds ratio 9.5, 95% confidence interval 1.3–68.3). In multiple linear regression analysis, TE values (which evaluated fibrosis) correlated negatively with free thyroxine levels. Conclusion: The results of this study strengthen the hypothesis that hepatic steatosis is associated with autoimmune (positive anti-TPO) subclinical hypothyroidism, independently from BMI. However, subclinical hypothyroidism alone does not appear to be associated with a significantly increased risk of hepatic fibrosis. Objective (TE (CAP crosssectional cross sectional BMImatched matched antiTPO anti TPO (anti-TPO antibodies 6 years thyroidstimulating stimulating TSH (TSH 100 10 0 10. mIUIL mIUI L mIUI/L 3 kgm2 kgm kg m2 m kg/m2 diabetes diseases kPa F0 F (F0 F3. F3 . (F3) dB/m dBm dB lowgrade low grade S1 S (S1 S3 (S3 Results enrolled 2 4 25.9% 259 25 9 (25.9 73 7 7.3% respectively 0.034. 0034 0.034 034 0.034) odds 95 5 9.5 1.3–68.3. 13683 1.3–68.3 1 1.3–68.3) analysis which levels Conclusion positive However kg/m (F (F3 (S 25.9 (25. 7.3 003 0.03 03 9. 1368 1.3–68. 25. (25 7. 00 0.0 136 1.3–68 (2 0. 13 1.3–6 ( 1.3– 1.3 1.

Resumo A violência direcionada à mulher é definida como todo ato resultante das relações de gênero que cause morte, dano físico, sexual, psicológico, patrimonial e moral. O cuidado integral possibilita que o profissional conheça a rede de apoio, a fim de orientá-las e encaminhá-las aos serviços, e valorize queixas/anseios. Objetivou-se identificar a produção científica acerca do cuidado integral às mulheres vítimas de violência. Trata-se de uma revisão integrativa da literatura. A coleta de dados ocorreu com busca pareada e independente de duas pesquisadoras, nos bancos Scopus, PubMed, CINAHL, Web of Science, LILACS, BDENF e SciELO, no período de janeiro e fevereiro de 2023. Foram utilizados critérios de elegibilidade, Descritores em Ciências da Saúde e Medical Subject Headings, totalizando dez artigos. Na análise dos dados, utilizou-se o software Iramuteq. Verificou-se grandes desafios para o cuidado integral, e que a violência contra a mulher, por ser uma problemática social grave, demanda políticas de saúde, educação, assistência social e segurança pública. Conclui-se que as ações integrais no cuidado à mulher vítima de violência demonstram forte vínculo com as práticas de acolhimento, humanização, além de perpassarem o âmbito interdisciplinar e intersetorial. morte físico sexual psicológico moral apoio orientálas orientá las encaminhálas encaminhá serviços queixasanseios queixas anseios queixas/anseios Objetivouse Objetivou se Tratase Trata literatura pesquisadoras Scopus PubMed CINAHL Science LILACS SciELO 2023 elegibilidade Headings artigos utilizouse utilizou Iramuteq Verificouse Verificou grave saúde educação pública Concluise Conclui acolhimento humanização intersetorial 202 20 2

Abstract Violence against women is defined as any act resulting from gender relations that cause death or physical, sexual, psychological, property and moral harm. Comprehensive care requires professionals understanding the support network to guide and refer women victims of violence to services and to value complaints/anxieties. The objective of this study was to identify the scientific production of comprehensive care for women victims of violence. This is an integrative literature review. Data collection was performed via a paired and independent search by two researchers in the Scopus, PubMed, CINAHL, Web of Science, LILACS, BDENF and SciELO databases between January and February 2023. After applying the eligibility criteria and descriptors in health sciences and medical subject headings, ten articles were retrieved. IRAMUTEQ software was used for data analyses. There are great challenges in implementing comprehensive care, and violence against women, as a serious social problem, demands health, education, social assistance and public security policies. The comprehensive actions taken in the care of women victims of violence demonstrate a strong link with the practices of reception and humanization, in addition to an interdisciplinary and intersectoral scope. physical sexual psychological harm complaintsanxieties complaints anxieties complaints/anxieties review Scopus PubMed CINAHL Science LILACS 2023 headings retrieved analyses problem education policies humanization scope 202 20 2

RESUMO Objetivo Identificar fatores associados ao internamento na unidade de terapia intensiva de crianças e adolescentes com COVID-19. Método Estudo de coorte retrospectiva, com dados secundários, de crianças e adolescentes hospitalizados (zero a 18 anos), notificados com COVID-19 na Paraíba, de abril de 2020 a julho de 2021, totalizando 486 registros. Foram realizadas análise descritiva, regressão logística e regressão multinível, considerando o nível de significância de 5%. Resultados Na regressão logística sem níveis hierárquicos, ocorreu aumento da chance de internamento na unidade de terapia intensiva em pacientes do sexo masculino (RC = 1,98; IC95% 1,18 - 3,32), com desconforto respiratório (RC = 2,43; IC95% 1,29 - 4,56), dispneia (RC = 3,57; IC95% 1,77 - 7,18) e residentes em cidades com grande porte populacional (RC = 2,70; IC95% 1,07 - 6,77). Foi observada diminuição da chance de cuidados intensivos com aumento da idade em anos (RC = 0,94; IC95%=0,90 - 0,97), presença de tosse (RC = 0,32; IC95% 0,18 - 0,59), febre (RC = 0,42; IC95% 0,23 - 0,74) e aumento no Índice de Gini (RC = 0,003; IC95% 0,000 - 0,243). Na análise multinível, a chance de internamento na unidade de terapia intensiva aumentou no sexo masculino (RC = 1,70; IC95%=1,68-1,71) e por conta do aumento no porte populacional do município a cada 100 mil habitantes (RC = 1,01; IC95% 1,01 - 1,03); a chance de internamento na unidade de terapia intensiva diminuiu em pacientes pardos versus não pardos (RC = 0,981; IC95% 0,97 - 0,99) e por conta do aumento a cada pontuação do Índice de Gini (RC = 0,02; IC95% 0,02 - 0,02). Conclusão Os efeitos das condições próprias do paciente e do contexto social na necessidade de cuidados intensivos em crianças e adolescentes com infecção pelo SARS-CoV-2 são mais bem estimados com a inclusão de um modelo de regressão multinível nas análises. COVID19. COVID19 COVID 19. 19 retrospectiva secundários zero 1 anos, , anos) COVID-1 Paraíba 202 2021 48 registros descritiva 5 5% hierárquicos RC 1,98 198 98 IC95 IC 118 1,1 3,32, 332 3,32 3 32 3,32) 2,43 243 2 43 129 29 1,2 4,56, 456 4,56 4 56 4,56) 3,57 357 57 177 77 1,7 7,18 718 7 2,70 270 70 107 07 1,0 6,77. 677 6,77 . 6 6,77) 0,94 094 0 94 IC95090 90 IC95%=0,9 0,97, 097 97 0,97) 0,32 032 018 0,1 0,59, 059 0,59 59 0,59) 0,42 042 42 023 23 0,2 0,74 074 74 0,003 0003 003 0000 000 0,00 0,243. 0243 0,243 0,243) 1,70 170 IC95%=1,681,71 IC95168171 IC95%=1,68 1,71 68 71 IC95%=1,68-1,71 10 101 01 1,03 103 03 1,03) 0,981 0981 981 0,9 0,99 099 99 002 02 0,0 0,02. 0,02) SARSCoV2 SARSCoV SARS CoV SARS-CoV- análises COVID1 COVID- 20 1,9 9 IC9 11 1, 33 3,3 2,4 24 12 45 4,5 3,5 35 17 7,1 2,7 27 67 6,7 09 IC9509 IC95%=0, 0,3 0, 05 0,5 0,4 04 0,7 00 024 0,24 681 IC95%=1,681,7 IC9516817 IC95168 IC95%=1,6 171 IC95%=1,68-1,7 0,98 098 SARS-CoV 3, 2, 4, 7, 6, IC950 IC95%=0 IC95%=1,681, IC951681 IC9516 IC95%=1, IC95%=1,68-1, IC95%= IC95%=1,681 IC951 IC95%=1 IC95%=1,68-1 IC95%=1,68-

ABSTRACT Objective To identify factors associated with hospitalization in the intensive care unit in children and adolescents with COVID-19. Methods This was a retrospective cohort study using secondary data of hospitalized children and adolescents (zero to 18 years old) with COVID-19 reported in Paraíba from April 2020 to July 2021, totaling 486 records. Descriptive analysis, logistic regression and multilevel regression were performed, utilizing a significance level of 5%. Results According to logistic regression without hierarchical levels, there was an increased chance of admission to the intensive care unit for male patients (OR = 1.98; 95%CI 1.18 - 3.32), patients with respiratory distress (OR = 2.43; 95%CI 1.29 - 4.56), patients with dyspnea (OR = 3.57; 95%CI 1.77 - 7.18) and patients living in large cities (OR = 2.70; 95%CI 1.07 - 6.77). The likelihood of requiring intensive care was observed to decrease with increasing age (OR = 0.94; 95%CI = 0.90 - 0.97), the presence of cough (OR = 0.32; 95%CI 0.18 - 0.59) or fever (OR = 0.42; 95%CI 0.23 - 0.74) and increasing Gini index (OR = 0.003; 95%CI 0.000 - 0.243). According to the multilevel analysis, the odds of admission to the intensive care unit increased in male patients (OR = 1.70; 95%CI = 1.68-1.71) and with increasing population size of the municipality per 100,000 inhabitants (OR = 1.01; 95%CI 1.01-1.03); additionally, the odds of admission to the intensive care unit decreased for mixed-race versus non-brown-skinned patients (OR = 0.981; 95%CI 0.97 - 0.99) and increasing Gini index (OR = 0.02; 95%CI 0.02 - 0.02). Conclusion The effects of patient characteristics and social context on the need for intensive care in children and adolescents with SARS-CoV-2 infection were better estimated with the inclusion of a multilevel regression model. COVID19. COVID19 COVID 19. 19 zero 1 old COVID-1 202 2021 48 records analysis performed 5 5% levels OR 1.98 198 98 95CI CI 95 118 1.1 3.32, 332 3.32 , 3 32 3.32) 2.43 243 2 43 129 29 1.2 4.56, 456 4.56 4 56 4.56) 3.57 357 57 177 77 1.7 7.18 718 7 2.70 270 70 107 07 1.0 6.77. 677 6.77 . 6 6.77) 0.94 094 0 94 090 90 0.9 0.97, 097 97 0.97) 0.32 032 018 0.1 0.59 059 59 0.42 042 42 023 23 0.2 0.74 074 74 0.003 0003 003 0000 000 0.00 0.243. 0243 0.243 0.243) 1.70 170 1.681.71 168171 1.68 1.71 68 71 1.68-1.71 100000 100 100,00 1.01 101 01 1.011.03 101103 1.03 03 1.01-1.03) additionally mixedrace mixed race nonbrownskinned non brown skinned 0.981 0981 981 0.99 099 99 002 02 0.0 0.02. 0.02) SARSCoV2 SARSCoV SARS CoV SARS-CoV- model COVID1 COVID- 20 1.9 9 11 1. 33 3.3 2.4 24 12 45 4.5 3.5 35 17 7.1 2.7 27 10 67 6.7 09 0. 0.3 0.5 05 0.4 04 0.7 00 024 0.24 681 1.681.7 16817 168 1.6 171 1.68-1.7 10000 100,0 011 1.011.0 10110 103 1.01-1.03 0.98 098 SARS-CoV 3. 2. 4. 7. 6. 1.681. 1681 16 1.68-1. 1000 100, 1.011. 1011 1.01-1.0 1.681 1.68-1 1.011 1.01-1. 1.68- 1.01-1 1.01-

Abstract Objective To evaluate whether antimicrobial photodynamic therapy (aPDT) repairs bisphosphonate-related osteonecrosis of the jaw (BRONJ) modulated by the reduction of NF-kB protein in a murine model. Methodology Male Wistar rats (N=30) were divided into the following groups (n=6/group): negative control (NC); experimental osteonecrosis (ONE); ONE + photosensitizer (PS); ONE + photobiomodulation (PBM); and ONE + aPDT. Over 8 weeks, ONE was induced by zoledronic acid 250 µg/kg injections, except in the NC group, which received sterile 0.9% saline, followed by extraction of the lower left first molar. Red light laser irradiation (wavelength ~660 nm, power 50 mW, energy of 2 J, energy dose of 66.67 J/cm2 for 40 s) was performed once a week for 4 weeks. Methylene blue 0.3% was used as PS. The animals were euthanized and examined macroscopically for the presence of exposed bone and epithelial repair and microscopically by histochemical (hematoxylin-eosin and Masson’s trichrome staining) and immunohistochemical (anti-NF-kB) methods. Macroscopic and histomorphometric data were analyzed by one-way ANOVA and Tukey’s post-test (p<0.05). Results Mucosal repair, viable osteocytes, and NF-kB immunostaining were observed in the NC, ONE+PS, ONE+PBM, and ONE+aPDT groups. The ONE group showed no mucosal repair, showing empty lacunae and multifocal immunostaining for NF-kB. The ONE+PBM and ONE+aPDT groups had greater deposition of extracellular matrix and less necrotic bone tissue (p<0.05). Conclusion PBM and aPDT treatments for BRONJ were effective for bone and epithelial repair, in addition to reducing inflammation mediated by the decrease of NF-kB protein in the irradiated regions. (aPDT bisphosphonaterelated bisphosphonate related (BRONJ NFkB NF kB model N=30 N30 N 30 (N=30 n=6/group n6group ngroup n 6 (n=6/group) (NC) (ONE) PS (PS) (PBM) weeks 25 µgkg µg kg injections 09 0 9 0.9 saline molar wavelength 660 ~66 nm 5 mW J 6667 66 67 66.6 Jcm2 Jcm cm2 cm J/cm s 03 3 0.3 hematoxylineosin hematoxylin eosin Massons Masson staining antiNFkB anti (anti-NF-kB methods oneway one way Tukeys Tukey posttest post test p<0.05. p005 p p<0.05 . 05 (p<0.05) osteocytes ONEPS ONE+PS ONEPBM ONEaPDT NFkB. kB. regions N=3 N3 (N=3 (n=6/group (NC (ONE (PS (PBM 0. ~6 666 66. p00 p<0.0 (p<0.05 N= (N= ~ p0 p<0. (p<0.0 (N p<0 (p<0. p< (p<0 (p< (p

Abstract Luffa operculata (L.) Cogn. (Cucurbitaceae) aqueous extract (EBN) was gestationally administered to Wistar rats to evaluate sex-related behavioral changes in young individuals receiving a two-hit stimulus of 1 mg/kg EBN, followed by stress challenge (NYM) or lipopolysaccharide (LPS) exposure. EBN exposition occurred by gavage at gestational days (GDs) 17 to 21, and NYM or LPS was conducted at post-natal day 60 (PND60). Behavior was evaluated in the open field (OF) and light-dark box (LDB) apparatuses. Serum hormones, pro- inflammatory cytokines, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and creatinine were measured. The liver and kidneys were histologically evaluated. Male and female young rats responded differently in latency to the light side and locomotion frequency on the dark side, corticosterone (females, LPS), and ACTH (females, stress). Male rats showed improved TNF-α (LPS group) and melatonin (LPS group). No histological or biochemical differences were observed in the liver or kidneys. Female young rats were more resilient to the two-hit-stimulus than the male rats. The gestational administration of EBN to male and female Wistar rats and a second stimulus (stress challenge or LPS exposure) at a young age allowed for discriminating differences in behavior, stress hormones, and cytokines according to the sex of the rat. However, no histological alterations in the liver or kidneys were observed, nor in the AST, ALT, or creatinine levels. L. L (L. Cogn Cucurbitaceae (Cucurbitaceae (EBN sexrelated related twohit two hit mgkg mg kg (NYM exposure GDs (GDs 21 postnatal post natal 6 PND60. PND60 PND . (PND60) OF (OF lightdark LDB (LDB apparatuses hormones pro AST , (AST) ALT (ALT) measured females, females (females LPS, LPS) stress. stress) TNFα TNF α group group. twohitstimulus behavior rat However levels (L 2 PND6 (PND60 (AST (ALT (PND6 (PND