ABSTRACT Haff disease was first described at the beginning of the twentieth century in Europe. Almost a century later, thousands of cases have now been reported in different countries. In Brazil, most cases are observed in the Amazon region, and its associated factors remain to be fully understood. This disease is an uncommon syndrome characterized by intense myalgia and rhabdomyolysis, which manifests within 24 h after consuming some types of freshwater or saltwater fish and crustaceans. A possible heat-stable toxin contained in seafood may be the cause of Haff disease, but this hypothesis is not yet completely proven. This review will describe the clinical and epidemiological aspects of Haff disease with updated literature. Europe later countries Brazil region understood rhabdomyolysis 2 crustaceans heatstable heat stable proven literature

RESUMO Objetivo: Avaliar se o uso do ELMO, um capacete para ventilação não invasiva criado no Brasil, teve impacto positivo no prognóstico de pacientes com insuficiência respiratória hipoxêmica por COVID-19 grave. Métodos: Estudo retrospectivo com 50 pacientes críticos com COVID-19. Dados epidemiológicos, clínicos e laboratoriais foram coletados na admissão na UTI e antes, durante e após o uso do ELMO. Os pacientes foram divididos em dois grupos (sucesso e falha) de acordo com o desfecho. Resultados: O uso do ELMO melhorou parâmetros de oxigenação como Pao2, Fio2 e relação Pao2/Fio2, e isso contribuiu para uma redução gradual da Fio2, sem aumento do CO2, conforme determinado pela gasometria arterial. Os pacientes do grupo sucesso apresentaram sobrevida significativamente maior (p < 0,001), conforme determinado pela análise de Kaplan-Meier, menor necessidade de intubação (p < 0,001), menos dias de hospitalização e menor incidência de lesão renal aguda em comparação com os do grupo falha. Conclusões: A significativa melhora nos parâmetros de oxigenação, a maior sobrevida, refletida pela menor necessidade de intubação e pela taxa de mortalidade, e a ausência de lesão renal aguda sugerem que o sistema ELMO CPAP é uma ferramenta promissora para o tratamento da SDRA e de condições clínicas semelhantes. Objetivo Brasil COVID19 COVID 19 COVID-1 grave Métodos 5 COVID19. 19. epidemiológicos antes falha desfecho Resultados Pao2 Pao Fio Pao2Fio2 PaoFio Pao2/Fio2 CO2 CO arterial p 0,001, 0001 0,001 , 0 001 0,001) KaplanMeier, KaplanMeier Kaplan Meier, Meier Kaplan-Meier Conclusões mortalidade semelhantes COVID1 1 COVID- Pao2Fio Pao2/Fio 000 0,00 00 0,0 0,

ABSTRACT Objective: To assess whether the use of ELMO, a helmet for noninvasive ventilation created in Brazil, had a positive impact on the prognosis of patients with hypoxemic respiratory failure caused by severe COVID-19. Methods: This is a retrospective study of 50 critically ill COVID-19 patients. Epidemiological, clinical, and laboratory data were collected on ICU admission, as well as before, during, and after ELMO use. Patients were divided into two groups (success and failure) according to the outcome. Results: ELMO use improved oxygenation parameters such as Pao2, Fio2, and the Pao2/Fio2 ratio, and this contributed to a gradual reduction in Fio2, without an increase in CO2, as determined by arterial blood gas analysis. Patients in the success group had significantly longer survival (p < 0.001), as determined by the Kaplan-Meier analysis, less need for intubation (p < 0.001), fewer days of hospitalization, and a lower incidence of acute kidney injury in comparison with those in the failure group. Conclusions: The significant improvement in oxygenation parameters, the longer survival, as reflected by the reduced need for intubation and by the mortality rate, and the absence of acute kidney injury suggest that the ELMO CPAP system is a promising tool for treating ARDS and similar clinical conditions. Objective Brazil COVID19. COVID19 COVID 19. 19 Methods 5 COVID-1 Epidemiological admission before during outcome Results Pao2 Pao Fio2 Fio Pao2Fio2 PaoFio Pao2/Fio ratio CO2 CO analysis p 0.001, 0001 0.001 , 0 001 0.001) KaplanMeier Kaplan Meier hospitalization Conclusions rate conditions COVID1 1 COVID- Pao2Fio 000 0.00 00 0.0 0.

Abstract Bothrops are one of the most common medically important snakes found in Latin America. Its venom is predominantly hemotoxic and proteolytic, which means that local lesion (edema and redness) and hemorrhagic symptoms are recurrent in envenoming by this snake. Although hemorrhage is usually the major cause of death, snakebite-related acute kidney injury is another potentially fatal clinical complication that may lead to chronic kidney disease. The present review highlights the main studies on Bothrops venom-related acute kidney injury, including observational, cross-sectional, case-control and cohort human studies available up to December 2019. The following descriptors were used according to Medical Subject Headings (MeSH): on Medline/Pubmed and Google Scholar “acute kidney injury” or “kidney disease” and “Bothrops”; on Lilacs and SciELO “kidney disease” or “acute kidney injury” and “Bothrops”. Newcastle-Ottawa quality assessment scale was used to appraise the quality of the cross-sectional and cohort studies included. The selection of more severe patients who looked for health care units and tertiary centers is a risk of bias. Due to the methodological heterogeneity of the studies, a critical analysis of the results was performed based on the hypothesis that the design of the included studies influences the incidence of acute kidney injury. Fifteen human studies (total participants 4624) were included according to stablished criteria. The coagulation abnormalities (hemorrhagic symptoms, abnormal fibrinogen and activated partial thromboplastin time) were associated with acute kidney injury in the most recent studies reported. The findings observed in this review provide up-to-date evidence about the acute kidney injury pathogenesis following Bothrops syndrome. Studies pointed out that coagulation abnormalities comprise the major pathway for acute kidney injury development. This review may improve patient management by primary healthcare providers, allowing earlier diagnosis and treatment of Bothrops venom-related acute kidney injury.

ABSTRACT Bothrops erythromelas are serpents that belong to the Viperidae family, which are the main species responsible for human snakebites in Ceara State, Northeast Brazil. Thrombotic microangiopathy (TMA) is an uncommon group of disorders characterized by microangiopathic hemolytic anemia (MAHA), thrombocytopenia and acute kidney injury (AKI), and occurrence after snakebites have been rarely reported. In this report, we described the case of a 57 year-old-man without comorbidities who was bitten by a Bothrops erythromelas on his right ankle. He presented with pain, edema and local bleeding. Symptomatology and laboratory tests were compatible with the diagnosis of TMA. He received specific antivenom and fluids replacement without any anaphylactic reaction. The conservative treatment was effective and there was no need for red blood cells transfusion or plasmapheresis. The aim of this report was to describe the first case of thrombotic microangiopathy following Bothrops erythromelas envenoming in the Northeast Brazil, providing insights about important mechanistic pathways of Bothrops snakebite-associated TMA and how to change the prognosis of the disease.

Abstract INTRODUCTION: Loxoscelism is a clinical condition involving spiders of the genus Loxosceles. One of the most severe complications is acute kidney injury (AKI). This study aimed to investigate AKI and other complications associated with loxoscelism. METHODS: We analyzed cases diagnosed with loxoscelism in an area where most accidents were caused by Loxosceles amazonica from January 2010 to December 2015. AKI was defined according to the KDIGO criteria. RESULTS: Forty-five patients were recorded: 95.6% presented characteristic necrotic skin lesions and 13.3% AKI. CONCLUSIONS: Loxoscelism could cause kidney involvement which is uncommon and could lead to the death of these patients.

ABSTRACT Despite the high number of accidents due to scorpion stings in Brazil, severe cases in adults are seldomly reported. In the Northeast region of Brazil, Tityus stigmurus is the most prevalent species. A 69 year-old woman who was stung by a scorpion attended the emergency room 5 hours after envenomation. She got worse due to abdominal pain. Clinical findings were concordant with class III scorpion envenomation (major systemic manifestations), complicated by acute kidney injury and acute pancreatitis. Intensive supportive therapy was adopted. In the follow-up, 3 months later, she was completely recovered. This report is being brought to recommend the thorough management of victims of scorpion accidents, enabling early diagnosis of severe complications, which could lead to death if aggressive supportive measures are not early and adequately taken.

Resumo Objetivo: descrever casos de tentativa de suicídio por exposição a agentes tóxicos registrados pelo Centro de Informação e Assistência Toxicológica em Fortaleza, Ceará, Brasil. Métodos: estudo descritivo com dados secundários sobre casos registrados em 2013. Resultados: foram registrados 410 casos; 56,2% dos indivíduos eram do sexo feminino e 79,7% tinham de 12 a 39 anos de idade; a maioria (86,4%) residia em áreas urbanas e 67,2% em Fortaleza; em 94,9% dos casos o local de exposição foi o domicílio; os agentes tóxicos mais envolvidos nos casos foram praguicidas (42,9%), principalmente agrotóxicos (30,2%), medicamentos (39,5%) e saneantes de uso doméstico (3,4%); das 16 tentativas de suicídio que resultaram em óbito, 15 foram ocasionadas por agrotóxicos. Conclusão: o estudo evidencia que a ingestão de agentes tóxicos, especialmente os agrotóxicos, é um importante método utilizado em tentativas de suicídio, sendo fundamental a integração das ações de promoção e de prevenção nessas ocorrências.

Abstract Objective: to describe cases of suicide attempts by exposure to toxic agents registered by the Toxicological Information and Assistance Center in Fortaleza, Ceará, Brazil. Methods: this is a descriptive study using secondary data of the cases registered in 2013. Results: 410 cases were registered; 56.2% of the individuals were female and 79.7% were between 12 and 39 years old; most of them (86.4%) lived in urban areas and 67.2%, in Fortaleza; in 94.9% of the cases, the exposure took place in the individual’s own home; the toxic agents most commonly used were pesticides (42.9%), especially for agricultural use (30.2%), medicines (39.5%) and house cleaning products (3.4%); of 16 suicide attempts that resulted in death, 15 were caused by agricultural pesticides. Conclusion: the study shows that the intake of toxic agents, especially of agricultural pesticides, is a common method used in suicide attempts; the integration between actions of promotion and prevention are essential.

Resumen Objetivo: describir los fármacos utilizados y analizar los factores asociados a la polifarmacia en ancianos de Aiquara, Bahía, Brasil. Métodos: se trata de un estudio transversal, censo, realizado en febrero de 2014, a través de entrevistas con formularios estandarizados. Resultados: entre los 272 ancianos entrevistados, 53,3% utilizaban la medicación prescrita y solamente 31,6% al menos un medicamento sin receta médica; la prevalencia de polifarmacia fue 29,0%; los medicamentos cardiovasculares fueron los más utilizados (n=390; 37,6%); en análisis ajustados, los factores asociados a la polifarmacia fueron sexo femenino (OR=2,20 - IC95% 1,11;4,35), seguro de salud privado (OR=2,18 - IC95% 1,05;4,55), haber sido hospitalizados en el último año (OR=2,34 - IC95% 1,1;4,65) y auto-reporte de cuatro o más enfermedades (OR=3,18 - IC95% 1,60;6,29). Conclusión: hubo una alta prevalencia de polifarmacia, asociada al sexo, plan de salud privado, tener cuatro o más enfermedades auto-reportados y haber sido hospitalizado en el último año, con un mayor uso de fármacos cardiovasculares.

Resumo Objetivo: descrever casos de tentativa de suicídio por exposição a agentes tóxicos registrados pelo Centro de Informação e Assistência Toxicológica em Fortaleza, Ceará, Brasil. Métodos: estudo descritivo com dados secundários sobre casos registrados em 2013. Resultados: foram registrados 410 casos; 56,2% dos indivíduos eram do sexo feminino e 79,7% tinham de 12 a 39 anos de idade; a maioria (86,4%) residia em áreas urbanas e 67,2% em Fortaleza; em 94,9% dos casos o local de exposição foi o domicílio; os agentes tóxicos mais envolvidos nos casos foram praguicidas (42,9%), principalmente agrotóxicos (30,2%), medicamentos (39,5%) e saneantes de uso doméstico (3,4%); das 16 tentativas de suicídio que resultaram em óbito, 15 foram ocasionadas por agrotóxicos. Conclusão: o estudo evidencia que a ingestão de agentes tóxicos, especialmente os agrotóxicos, é um importante método utilizado em tentativas de suicídio, sendo fundamental a integração das ações de promoção e de prevenção nessas ocorrências.

Abstract Objective: to describe cases of suicide attempts by exposure to toxic agents registered by the Toxicological Information and Assistance Center in Fortaleza, Ceará, Brazil. Methods: this is a descriptive study using secondary data of the cases registered in 2013. Results: 410 cases were registered; 56.2% of the individuals were female and 79.7% were between 12 and 39 years old; most of them (86.4%) lived in urban areas and 67.2%, in Fortaleza; in 94.9% of the cases, the exposure took place in the individual’s own home; the toxic agents most commonly used were pesticides (42.9%), especially for agricultural use (30.2%), medicines (39.5%) and house cleaning products (3.4%); of 16 suicide attempts that resulted in death, 15 were caused by agricultural pesticides. Conclusion: the study shows that the intake of toxic agents, especially of agricultural pesticides, is a common method used in suicide attempts; the integration between actions of promotion and prevention are essential.

Resumen Objetivo: describir los fármacos utilizados y analizar los factores asociados a la polifarmacia en ancianos de Aiquara, Bahía, Brasil. Métodos: se trata de un estudio transversal, censo, realizado en febrero de 2014, a través de entrevistas con formularios estandarizados. Resultados: entre los 272 ancianos entrevistados, 53,3% utilizaban la medicación prescrita y solamente 31,6% al menos un medicamento sin receta médica; la prevalencia de polifarmacia fue 29,0%; los medicamentos cardiovasculares fueron los más utilizados (n=390; 37,6%); en análisis ajustados, los factores asociados a la polifarmacia fueron sexo femenino (OR=2,20 - IC95% 1,11;4,35), seguro de salud privado (OR=2,18 - IC95% 1,05;4,55), haber sido hospitalizados en el último año (OR=2,34 - IC95% 1,1;4,65) y auto-reporte de cuatro o más enfermedades (OR=3,18 - IC95% 1,60;6,29). Conclusión: hubo una alta prevalencia de polifarmacia, asociada al sexo, plan de salud privado, tener cuatro o más enfermedades auto-reportados y haber sido hospitalizado en el último año, con un mayor uso de fármacos cardiovasculares.

OBJECTIVES: Visceral leishmaniasis (VL) is endemic in Brazil and appears to occur in epidemic form in the state of Ceará. Few epidemiologic studies have been done on VL in this state. The aim of this study is to establish the epidemiologic pattern of VL in Fortaleza City and to show how urbanization has occurred in recent years. METHODS: Data were obtained from the State Health Department of Fortaleza, Ceará, and included all cases of VL registered in Fortaleza from January 2001 to December 2006. RESULTS: There were a marked increase and an elevated incidence of cases of VL in urban areas. Children and young people were the most affected group. CONCLUSION: The epidemic occurrence of VL in the region must convince authorities to adopt more adequate policies of disease control.

OBJETIVOS: La leishmaniasis visceral (LV) es endémica en Brasil y suele ocurrir en forma epidémica en el estado de Ceará. Se han realizado pocos estudios epidemiológicos sobre LV en ese estado. El objetivo de este estudio es establecer el patrón epidemiológico de LV en la ciudad de Fortaleza y mostrar cómo ha ocurrido la urbanización de esta enfermedad en los últimos años. MÉTODOS: Los datos se obtuvieron del Departamento Estatal de Salud de Fortaleza, Ceará, y abarcaron todos los casos de LV registrados en esa ciudad entre enero de 2001 y diciembre de 2006. RESULTADOS: Se observó un marcado incremento y una elevada incidencia de LV en las áreas urbanas. Los niños y jóvenes fueron los grupos más afectados. CONCLUSIÓN: La ocurrencia de epidemias de LV en la región debe convencer a las autoridades para que adopten políticas más apropiadas para el control de esta enfermedad.