Abstract Background Childhood and adolescence are dynamic period in terms of nevogenesis, and the development and growth of new melanocytic nevus are frequently observed. In this study, the aim was to examine the pattern and diameter changes seen in the follow-up of pediatric melanocytic nevus. Objectives To describe the pattern and diameter changes seen in the follow-up of pediatric melanocytic. Methods Our study involved the assessment of 301 pediatric melanocytic nevi in 50 patients attended at the Dermatology Clinic of Istanbul Training and Research Hospital between January 2008 and 2022. The pediatric melanocytic nevi were diagnosed clinically and dermoscopically. Subsequently, we conducted video-dermoscopic monitoring of these nevi over a span of 3 months to 3 years. Results 46% of our patients were female (n = 23), with a mean age of 11.5 years. While the pattern of nevi was globular in 40% patients, the rate of globular pattern decreased to 30% in the follow-up. The basal homogeneous nevus pattern was seen in 10% patients, but was detected in 13.9% in the follow-up. Peripheral globules were observed in 19.3% of the cases, but in the follow-up, 61.1% of the globules regressed completely. Nevus excision was indicated in only 11 of 301 nevi. Study limitations Single-center study and a small of studies available on this subject. Conclusions Pediatric melanocytic nevi can show dynamic changes compared to nevi in adults. In this study, growth rates, dermoscopic features, and pattern changes seen in the follow-up of melanocytic nevi were evaluated. The globular pattern was observed most frequently. The presence of peripheral globules is frequently observed in pediatric melanocytic nevi with regression during the follow-up period. nevogenesis followup follow up 30 5 200 2022 dermoscopically Subsequently videodermoscopic video years 46 n 23, 23 , 23) 115 11. 40 followup. up. 10 139 13 9 13.9 193 19 19.3 cases followup, up, 611 61 1 61.1 completely Singlecenter Single center subject adults rates features evaluated 20 202 4 2 13. 19. 6 61.

Abstract Background Direct immunofluorescence (DIF) panels are usually ordered for clinically suspected cutaneous vasculitis, but their positivity rate is variable, and their prognostic significance is not clear to date. Objective The study aims to investigate the systemic involvement rate in leukocytoclastic vasculitis (LCV) patients and the potential clinical and laboratory associations with systemic involvement, including DIF findings. Methods A retrospective study of patients with histopathologically proven cutaneous LCV examined in the dermatology department between 2013 and 2017 was performed. Results Of the 81 patients (mean age, 50.6 years), 42 (52%) were male. The mean time between the appearance of skin lesions and biopsy was 23.1 days, ranging from 2 to 180 days. DIF showed overall positivity of 90.1%, and C3 was the most frequent immunoreactant (82.7%). Any kind of extracutaneous involvement was present in 47 (58%) of patients, with renal involvement being the most frequent (53.1%), followed by articular (18.5%) and gastrointestinal (11.1%) involvement. The presence of renal disease was associated with the detection of IgG in the lesional skin (p = 0.017), and with the absence of IgM in the lesional skin (p = 0.032). There was a significant association between C3 deposition and joint involvement (p = 0.05). Study limitations This is a single-center study with a retrospective design. Conclusion DIF seems to be a useful ancillary diagnostic tool in the evaluation of cutaneous vasculitis, but the relationship between DIF findings and systemic involvement needs to be further elucidated due to contradictory data in the current literature. (DIF variable date (LCV 201 performed 8 age 506 50 6 50. years, years , years) 4 52% 52 (52% male 231 23 1 23. days 18 901 90 90.1% C 82.7%. 827 82.7% . 82 7 (82.7%) 58% 58 (58% 53.1%, 531 53.1% 53 (53.1%) 18.5% 185 5 (18.5% 11.1% 111 11 (11.1% p 0.017, 0017 0.017 0 017 0.017) 0.032. 0032 0.032 032 0.032) 0.05. 005 0.05 05 0.05) singlecenter single center design literature 20 (52 9 90.1 82.7 (82.7% (58 53.1 (53.1% 18.5 (18.5 11.1 (11.1 001 0.01 01 003 0.03 03 00 0.0 (5 90. 82. (82.7 53. (53.1 18. (18. 11. (11. 0. ( (82. (53. (18 (11 (82 (53 (1 (8