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Abstract Considering that Helicobacter pylori, a bacterium able to colonize the upper gastrointestinal tract and cause mucosal injury, not always can be effectively eradicated by the traditional approaches, there is an interest in alternative therapies until a vaccine be available. Honey is a food supplement with high carbohydrate content and antioxidant activity, as well as broad antimicrobial spectrum. After analyzing the physicochemical and in vitro antimicrobial properties of an Apis mellifera honey from the Atlantic forest of Alagoas / Brazil, the purpose of the present work was evaluate its in vivo effects against Helicobacter pylori in the gastric mucosa of Wistar rats. First, it was verified the success of inoculation/infection of the pathogen in the gastric mucosa of the rats, through the subsequent removal of their stomachs for histological analysis (hematoxylin and eosin stain and Giemsa stain). Then, four groups of animals were treated with sterilized distilled deionized water, the Apis mellifera honey, a combination of omeprazole, amoxicillin and clarithromycin, and an association of such medicines and honey (1:1). Except the control, all treatments were effective in combating infection, however, honey reduced the inflammatory process, whilst the antibiotics increase the number of eosinophils.

https://doi.org/10.1590/1678-457x.31016 1712 downloads

Influence of Temporary Cements on the Bond Strength of Self-Adhesive Cement to the Metal Coronal Substrate
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Peixoto, Raniel Fernandes

; Aguiar, Caio Rocha de

; Jacob, Eduardo Santana

; Macedo, Ana Paula

; Mattos, Maria da Gloria Chiarello de

; Antunes, Rossana Pereira de Almeida

Brazilian Dental Journal

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dec 2015, Volume 26 N. 6 Pages 637 - 641

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Esta pesquisa avaliou a influência dos cimentos temporários (contendo eugenol [CE]ou livre de eugenol[LE]) na resistência à tração de copingsde Ni-Cr fixados com cimento resinoso auto-adesivo sobre substrato coronário metálico. Trinta e seis coroas provisórias foram divididas em 4 grupos (n=9) de acordo com os cimentos temporários: Provy, Dentsply (contendo eugenol), Temp Cem, Vigodent (contendo eugenol), RelyXTemp NE, 3M ESPE (livre de eugenol) andTemp Bond NE, KerrCorp (livre de eugenol). Após 24 h da cimentação temporária, testes de resistência à tração foram realizados em uma máquina universal de ensaios, com velocidade de 0,5 mm/min. e célula de carga de 1kN (100 kgf). Em seguida, os núcleos metálicos fundidos foram limpos por meio de raspagem com cureta ejatos de ar. Trinta e seis copings de Ni-Cr foram cimentados sobre os núcleos metálicos com cimento resinoso auto-adesivo (RelyX U200, 3M ESPE). Testes de resistência à tração foram novamente realizados. Na cimentação provisória, Temp Bond NE (12,91±2,54) e Temp Cem (12,22±2,96) apresentaram os maiores valores de resistência à tração e foram estatisticamente semelhantes entre si (p>0,05). Diferença estatisticamente significante (p<0.05) foi observada apenas entre Provy (164,44±31,23) e Temp Bond NE (88,48±21,83)após cimentação dos copingsdeNi-Cr com cimento resinoso auto-adesivo. Além disso, Temp Cem (120,68±48,27) e RelyX Temp NE (103,04±26,09) mostraram valores intermediários de resistência à tração. Em conclusão, o cimento temporário contendo eugenol, Proxy, foi associado com a mais alta resistência de união do cimento resinoso, quando os copingsde Ni-Cr foram cimentados sobre os núcleos metálicos fundidos. Entretanto, o eugenol não pode ser considerado como um fator determinante no aumento da resistência de união, já que outros cimentos testados (1 contendo eugenol e 2 livres de eugenol) foram semelhantes.

This research evaluated the influence of temporary cements (eugenol-containing [EC] or eugenol-free [EF]) on the tensile strength of Ni-Cr copings fixed with self-adhesive resin cement to the metal coronal substrate. Thirty-six temporary crowns were divided into 4 groups (n=9) according to the temporary cements: Provy, Dentsply (eugenol-containing), Temp Cem, Vigodent (eugenol-containing), RelyX Temp NE, 3M ESPE (eugenol-free) and Temp Bond NE, Kerr Corp (eugenol-free). After 24 h of temporary cementation, tensile strength tests were performed in a universal testing machine at a crosshead speed of 0.5 mm/min and 1 kN (100 kgf) load cell. Afterwards, the cast metal cores were cleaned by scraping with curettes and air jet. Thirty-six Ni-Cr copings were cemented to the cast metal cores with self-adhesive resin cement (RelyX U200, 3M ESPE). Tensile strength tests were performed again. In the temporary cementation, Temp Bond NE (12.91±2.54) and Temp Cem (12.22±2.96) presented the highest values of tensile strength and were statistically similar to each other (p>0.05). Statistically significant difference (p<0.05) was observed only between Provy (164.44±31.23) and Temp Bond NE (88.48±21.83) after cementation of Ni-Cr copings with self-adhesive resin cement. In addition, Temp Cem (120.68±48.27) and RelyX Temp NE (103.04±26.09) showed intermediate tensile strength values. In conclusion, the Provy eugenol-containing temporary cement was associated with the highest bond strength among the resin cements when Ni-Cr copings were cemented to cast metal cores. However, the eugenol cannot be considered a determining factor in increased bond strength, since the other tested cements (1 eugenol-containing and 2 eugenol-free) were similar.

https://doi.org/10.1590/0103-6440201300362 2574 downloads

Serum concentration of nitric oxide in women smokers and nonsmokers with overweight
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Keulen, Henriqueta Vieira van

; Silva Gomes, Arthur da

; Toffolo, Mayla Cardoso Fernandes

; Oliveira, Erick Esteves

; Silva, Luan Cristian da

; Potente Dutra Luquetti, Sheila Cristina

; Ferreira, Ana Paula

; Aguiar, Aline Silva de

Nutrición Hospitalaria

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oct 2015, Volume 32 N. 4 Pages 1493 - 1499

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Aim: to evaluate the serum concentration of NO in overweight women, smokers (SG) and nonsmokers (NSG). Methods: blood samples from smokers (n = 20) and nonsmokers (n = 18) were collected to obtain serum, and stored at -80ºC until analysis. NO was assessed by measuring total nitrite, determined by Greiss method. It was adopted as reference 24.4 ìmol/L, mean value found in a study with healthy subjects without excess weight. We used the Student t test to compare the means of age and waist circumference, and the Mann-Whitney U test to compare the median of concentrations of nitrite, number of cigarettes/day and Body Mass Index. We adopted a significance level of p < 0.05. Results: the median nitrite in SG was 16.53 (2.79 - 69.72) µmol/L, whereas in NSG was 10.85 (1.44 - 43.25) µmol/L (p = 0.028). BMI median value to SG and NSG, was respectively 29.50 (25.00 - 38.14) kg/m² and 30.68 (25.10 - 36.98) kg/m² (p = 0.530), being classified as overweight. The data showing that the average nitrite was below the estimated value for healthy individuals. Conclusion: the results indicate a decrease of NO metabolites in women with excess weight, independently of being smoker. Despite the significant difference found between groups, these women had values well below the reference value of NO for healthy women. Therefore, it seems that smoking does not interfere in nitrite levels in patients already compromised by obesity.

Objetivo: evaluar la concentración sérica de NO en las mujeres con sobrepeso, fumadoras (SG) y no fumadoras (GSN). Método: se recogieron muestras de sangre de las fumadoras (n = 20) y no fumadoras (n = 18) para obtener el suero, y se almacenaron a -80 ºC hasta su análisis. NO se evaluó mediante la medición total de nitrito, determinado por el método Greiss. Fue adoptado como referencia de 24,4 µmol/L, valor medio que se encuentra en un estudio con sujetos sanos sin exceso de peso. Se utilizó la prueba t de Student para comparar las medias de edad y la circunferencia de la cintura, así como la prueba de Mann-Whitney para comparar la mediana de las concentraciones de nitrito, número de cigarrillos/día y el Índice de Masa Corporal. Hemos adoptado un nivel de significación de p < 0,05. Resultados: la mediana de SG nitrito fue 16,53 (2,79- 69,72) mol/L, mientras que en NSG fue 10,85 (1,44-43,25) µmol/L (p = 0,028). El IMC valor de la mediana de SG y NSG fue, respectivamente, 29,50 (25,00-38,14) kg/m² y 30,68 (25,10-36,98) kg/m² (p = 0,530), siendo clasificado como sobrepeso. Los datos muestran que el nitrito promedio estuvo por debajo del valor estimado para individuos sanos. Conclusiones: los resultados indican una disminución de los metabolitos NO en las mujeres con exceso de peso, independientemente de si son fumadoras o no. A pesar de la diferencia significativa entre los grupos, estas mujeres tenían valores muy por debajo del valor de referencia del NO para las mujeres sanas. Por lo tanto, parece que el fumar no interfiere en los niveles de nitritos en pacientes que ya están comprometidas por la obesidad.

https://doi.org/10.3305/nh.2015.32.4.9517 181 downloads

Prevention of peritoneal adhesion using a bacterial cellulose hydrogel, in experimental study
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Coelho Junior, Elísio Rodrigues

; Costa, Laura Olinda Bregieiro Fernandes

; Alencar, Arinaldo Vasconcelos

; Barbosa, Ana Paula Guimarães

; Pinto, Flávia Crisina Morone

; Aguiar, José Lamartine de Andrade

Acta Cirúrgica Brasileira

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mar 2015, Volume 30 N. 3 Pages 194 - 198

Abstract: En | Text: En | PDF: En

PURPOSE:To analyze the effectiveness of bacterial cellulose hydrogel as a barrier in preventing postoperative peritoneal adhesion in rat model.METHODS:Experimental study with 45 Wistar rats (Rattus norvegicus) that were divided into three groups for the following treatments: A. Saline, B. Oxidized Regenerated Cellulose (ORC) barrier, and C Bacterial Cellulose Hydrogel (BCH) barrier. After 45 days of the surgery the adhesions were classified and graded according to the qualitative score. The histological parameters were evaluated using a modified semi-quantitative scale to rate the extent of fibrosis, inflammatory reaction and vascular proliferation.RESULTS:Compared with the saline group (A), the treatments with ORC barrier (B) and BHC barrier (C) resulted in a smaller number of adhesions (p=0.019 and p=0.003 on Fisher's exact test, respectively). Data from inflammation and neovascularization showed no statistically significant difference between the groups BHC and ORC (p=0.426 and 0.446 on chi-square test, respectively).CONCLUSION: Bacterial cellulose hydrogel is effective as a bio-re-absorbable barrier for preventing postoperative peritoneal adhesions.

https://doi.org/10.1590/S0102-865020150030000005 2221 downloads

Validation of impregnation process for homeopathic globules by spectrophotometric-UV method
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Pinheiro, Mariana Santos

; Aguiar, Paula Fernandes de

; Quaresma, Carla Holandino

; Garcia, Sheila

Brazilian Journal of Pharmaceutical Sciences

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mar 2014, Volume 50 N. 1 Pages 137 - 146

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Compararam-se as técnicas de impregnação para glóbulos segundo o Manual de Normas Técnicas para Farmácias Homeopáticas (MNTFH) da Associação Brasileira de Farmacêuticos Homeopatas (ABFH), Farmacopeia Homeopática Brasileira (FHB) e variações destas técnicas. As variáveis avaliadas neste processo foram: três tamanhos diferentes de glóbulos (n.º 3, 5 e 7); a solução hidroalcóolica a 70% (v/v) de minoxidil a 2% (p/v) foi utilizada para impregnar os glóbulos nas concentrações de 2, 3, 4, 5% (v/p) e na impregnação a 10% (v/p) utilizaram-se as soluções hidroalcóolicas a 70, 80 e 90% (v/v); e quatro técnicas de impregnação diferentes ( A -vidro, B -papel, C -copo e D -FHB). A impregnação foi validada através da uniformidade de dose por conteúdo, sendo o minoxidil a substância quantificada. Como os resultados da uniformidade de dose por conteúdo não demonstraram distribuição normal, utilizaram-se o One way ANOVA e um modelo estatístico não paramétrico para sua avaliação. Considerando-se a média, o desvio padrão (DP), a variância individual de cada grupo e os gráficos de análise de componentes principais (ACP), observou-se que a impregnação que utilizou o glóbulo nº5, a concentração para impregnação de 5% (v/p), graduação alcoólica de 70% (v/v) e técnica “A” apresentou a melhor uniformidade de dose. Quanto à secagem, verificou-se a necessidade do uso de uma fonte de calor.

We compared the impregnation techniques for globules according to the Manual of Technical Norms for Homeopathic Pharmacies (MNTFH) of the Association of Homeopathic Pharmacists (ABFH), Brazilian Homeopathic Pharmacopoeia (FHB) and variations of these techniques. The variables were evaluated in this procedure, three different sizes of globules (N o . 3, 5 and 7), the hydroalcoholic solution of 70% (v/v) Minoxidil 2% (w/v) was used to impregnate the globules in concentrations of 2, 3, 4, 5% (v/w) and the impregnation at 10 %(v/w) was used hydroalcoholic solutions at 70, 80 and 90% (v/v), and four impregnation techniques various ( A -glass, B -paper, C -cup and D -FHB). As the results of content uniformity did not demonstrate a normal distribution, the one way ANOVA and a nonparametric statistical model were used for evaluation. Considering the average, the standard deviation (SD), the individual variance of each group and the principal components analysis graphs (PCA), it was observed that the “A” impregnation of globules technique, with 5% (v/w) of the impregnation concentrations and the No.5 globule presented the best uniformity of dose. As to the drying, there was a need to use a heat source.

https://doi.org/10.1590/S1984-82502011000100014 2296 downloads

Least squares regression with errors in both variables: case studies
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Oliveira, Elcio Cruz de

; Aguiar, Paula Fernandes de

Química Nova

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2013, Volume 36 N. 6 Pages 885 - 889

Abstract: En | Text: En | PDF: En

Analytical curves are normally obtained from discrete data by least squares regression. The least squares regression of data involving significant error in both x and y values should not be implemented by ordinary least squares (OLS). In this work, the use of orthogonal distance regression (ODR) is discussed as an alternative approach in order to take into account the error in the x variable. Four examples are presented to illustrate deviation between the results from both regression methods. The examples studied show that, in some situations, ODR coefficients must substitute for those of OLS, and, in other situations, the difference is not significant.

13754 downloads

Proximate composition and quantification of fatty acids in breaded chicken steak
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Tanamati, Ailey Aparecida Coelho

; Aguiar, Ana Carolina

; Boroski, Marcela

; Montanher, Paula Fernandes

; Souza, Nilson Evelázio de

; Godoy, Helena Teixeira

; Matsushita, Makoto

; Visentainer, Jesuí Vergílio

Food Science and Technology

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mar 2011, Volume 31 N. 1 Pages 178 - 183

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O objetivo deste estudo foi analisar a composição centesimal e de ácidos graxos de cinco marcas de steak empanado de frango (A, B, C, D e E). As análises de ácidos graxos foram realizadas por cromatografia gasosa e técnicas de quantificação absoluta. Os resultados experimentais foram comparados com valores constantes nos rótulos. Os valores encontrados para proteína de todas as marcas estavam em acordo com o estabelecido pela legislação brasileira, exceto o da amostra E, a qual apresentou o maior teor lipídico. Treze ácidos graxos foram identificados nas marcas avaliadas, sendo os majoritários os ácidos: oleico, linoleico e palmítico. As razões dos ácidos graxos poli-insaturados/ácidos graxos saturados encontraram-se dentro dos valores considerados adequados para a saúde humana, porém, as elevadas razões n-6/n-3 encontradas podem resultar em um desequilíbrio na ingestão destes ácidos graxos. Apenas amostras D e E podem ser consideradas livres de trans de acordo com a legislação vigente. A comparação entre os resultados das análises e os valores constantes nos rótulos apresentaram pequenas variações nos teores de proteína, entretanto, a maioria das marcas subestimou os teores de lipídios e valor energético. Os rótulos das marcas B e C declaravam-se livre de trans, entretanto os resultados obtidos apontam teores acima dos valores permitidos pela legislação para serem consideradas livre de trans.

The aim of this work was to analyze the fatty acid and proximate composition of five brands of breaded chicken steak (A, B, C, D, and E) by accurate chromatographic quantification and to compare the experimental results with food label nutrition facts. The protein values of all brands were in agreement with the Brazilian regulation values, except for that of sample E, which presented the highest lipid content. Thirteen fatty acids were identified in the studied brands and the major ones were oleic acid, linoleic acid, and palmitic acid. The polyunsaturated fatty acid/saturated fatty acid ratios were within the values considered appropriate for human health; however, the high n-6/n-3 ratios found can result in an unbalanced intake of these fat acids. Only samples D and E can be considered trans free according to the regulations. The comparison of the analyses' results and the food label nutrition facts showed little variation in protein values. Nevertheless, most brands underestimated their lipid and energy levels. Brand B and C labels declared "free of trans", but the obteined results showed levels excedding those especified by regulation to be considered trans free values.

3160 downloads

10.

Validação da metodologia da avaliação de incerteza em curvas de calibração melhor ajustadas por polinômios de segundo grau
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Oliveira, Elcio Cruz de

; Aguiar, Paula Fernandes de

Química Nova

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2009, Volume 32 N. 6 Pages 1571 - 1575

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

The most widespread literature for the evaluation of uncertainty - GUM and Eurachem - does not describe explicitly how to deal with uncertainty of the concentration coming from non-linear calibration curves. This work had the objective of describing and validating a methodology, as recommended by the recent GUM Supplement approach, to evaluate the uncertainty through polynomial models of the second order. In the uncertainty determination of the concentration of benzatone (C) by chromatography, it is observed that the uncertainty of measurement between the methodology proposed and Monte Carlo Simulation, does not diverge by more than 0.0005 unit, thus validating the model proposed for one significant digit.

6777 downloads

11.

Comparação de diferentes abordagens para avaliação da incerteza na cromatografia gasosa do gás natural
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Oliveira, Elcio Cruz de

; Aguiar, Paula Fernandes de

Química Nova

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2009, Volume 32 N. 6 Pages 1655 - 1660

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

The evaluation of uncertainty associated with an analytic result is an essential part of the measurement process. Recently, several approaches to evaluate the uncertainty in measurement have been developed. Here, the gas chromatography assay uncertainty for natural gas is compared by some of these approaches: the guide to the expression of uncertainty in measurement (GUM) approach, top-down approach (reproducibility estimate from an inter-laboratory study), Barwick & Ellison (data from validation), study of variability and fuzzy approach. The comparison shows that GUM, Barwick & Ellison and fuzzy approaches lead to comparable uncertainty evaluations, which does not happen with the top-down approach and study of variability by the absence of data normality.

4418 downloads

12.

Metodologia analítica para quantificar o teor de biodiesel na mistura biodiesel: diesel utilizando espectroscopia na região do infravermelho
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Guarieiro, Lílian Lefol Nani

; Pinto, Angelo C.

; Aguiar, Paula Fernandes de

; Ribeiro, Núbia Moura

Química Nova

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2008, Volume 31 N. 2 Pages 421 - 426

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Considered the best substitute for diesel, biodiesel can be blended with diesel in any ratio, bringing lots of environmental, economic and social advantages. Brazilian law Nº 11097/2005, proposes the introduction of biodiesel in to the Brazilian energy matrix, mixed with diesel at a minimum percentage of 2%. For consumers and sellers to be sure that the commercialized mixture of biodiesel:diesel contains the correct percentage, it is necessary to develop analytical methodologies to quantify the amount of biodiesel added. This work presents a fast, low-cost and simple methodology to determine the biodiesel proportion in mixtures of biodiesel:diesel, based on infrared spectroscopy.

13007 downloads

13.

Influence of processing parameters on structural characteristics of porous calcium phosphate samples: a study using an experimental design method
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Ugarte, José Fernandes de Oliveira

; Sena, Lidia Ágata de

; Pérez, Carlos André de Castro

; Aguiar, Paula Fernandes de

; Rossi, Alexandre Malta

; Soares, Glória Almeida

Materials Research

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mar 2005, Volume 8 N. 1 Pages 71 - 76

Abstract: En | Text: En | PDF: En

Synthetic porous ceramics can be used as three-dimensional scaffolds for bone repair. The aim of this work is to correlate process parameters with scaffolds structural characteristics. The factorial 2 level experimental design was chosen to study the effect of the Ca/P ratio (1.58 or 1.67), calcination temperature (1000 or 1150 °C) and porogen content (20 or 40%) on the calcium phosphate samples characteristics. The influence of such parameters was determined by X-ray diffraction, infrared spectroscopy and image analysis. It was observed that phase composition was basically a function of the Ca/P ratio of the raw material. The use of the porogen did not alter the hydroxyapatite (HA)/tricalcium phosphate (TCP) content, but induced changes in the relative content of TCP phase (alpha or beta). It is possible to design a porous sample with defined characteristics, and the model herein used can be considered as having a good predictive power.

3001 downloads

14.

Funções executivas em crianças fenilcetonúricas: variações em relação ao nível de fenilalanina
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Malloy-Diniz, Leandro Fernandes

; Cardoso-Martins, Cláudia

; Carneiro, Karina Cunha

; Cerqueira, Márcia Maria Magrille

; Ferreira, Ana Paula Almeida

; Aguiar, Marcos José B. de

; Starling, Ana Lúcia

Arquivos de Neuro-Psiquiatria

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jun 2004, Volume 62 N. 2b Pages 473 - 479

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Este estudo investiga a hipótese de um déficit específico das funções executivas em crianças com fenilcetonúria (PKU) cujo nível de fenilalanina encontra-se entre 360 e 600 mmol/l. Participaram do estudo 21 crianças fenilcetonúricas de nove meses de idade, tratadas precoce e continuamente, e 18 crianças normais de mesma idade. As crianças com PKU foram divididas em dois grupos em função do nível médio de fenilalanina antes do estudo: o grupo de crianças cujo nível encontrava-se entre 120 e 360 mmol/l e o grupo de crianças cujo nível encontrava-se entre 360 e 600 mmol/l. Embora os três grupos de crianças tenham apresentado desempenho semelhante em um teste que avalia o desenvolvimento mental global, as crianças com alto nível de fenilalanina apresentaram desempenho significativamente pior do que as demais crianças em um teste que avalia as funções executivas.

The present study investigates the hypothesis of a specific executive function deficit in children with Phenilketonuria (PKU) whose Phenilalanine level is between 360 and 600 mmol/l. Participants were 21 early and continuously treated 9-month-old children with PKU and 18 9-month-old controls. The children with PKU were divided into two groups on the basis of their mean phenilalanine level prior to the study: the group of children whose level was between 120 and 360 mmol/l, and the group of children whose level was between 360 and 600 mmol/l. Although the three groups did not differ with regard to performance on a test of global mental development, the PKU children with high phenilalanine performed significantly worse than both the low phenilalanine PKU children and the control children on a task that assesses executive functioning.

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