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1.
Prevalência e fatores associados à realização dos exames de triagem neonatal no Brasil: comparação da PNS 2013 e 2019 Brasil 201 20 2
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Melo, Wesley Soares de
; Brito, Leandro Cardozo dos Santos
; Oliveira, Bruno Luciano Carneiro Alves de
; Barbosa, Lorena Pinheiro
; Cardoso, Maria Vera Lúcia Moreira Leitão
.
Abstract This study analyzed the prevalence of complete neonatal screening (CNS) of children aged under 2 years in Brazil and associated factors using data from the 2013 (n=4,442) and 2019 (n=5,643) national health surveys. We conducted a cross-sectional study to compare prevalence of CNS (eye, ear and heel prick tests) adopting 95% confidence intervals (95%CI) and a 5% significance level. Crude and adjusted Poisson regression was performed to estimate prevalence ratios (PR) and 95%CI to assess the association between socioeconomic, demographic and health variables and CNS. There was a statistically significant increase in CNS prevalence, from 49.2% (95%CI: 47.1-51.3) in 2013 to 67.4% (95%CI: 65.5-69.3) in 2019. However, large disparities persist across states and between sociodemographic groups. In both years, CNS prevalence was lowest among brown and black children, those from families in the three lowest income quintiles, children without health insurance, those from families registered in the Family Health Strategy and children living in the North, cities outside the state capital/metropolitan regions and rural areas. Despite the increase in prevalence of CNS, deep individual and contextual inequalities persist, posing challenges for health policies. (CNS 201 n=4,442 n4442 n 4 442 (n=4,442 n=5,643 n5643 5 643 (n=5,643 surveys crosssectional cross sectional eye, eye (eye tests 95 95CI CI (95%CI level PR (PR socioeconomic 492 49 49.2 47.151.3 471513 47.1 51.3 47 1 51 3 47.1-51.3 674 67 67.4 65.569.3 655693 65.5 69.3 65 69 65.5-69.3 However groups quintiles insurance North capitalmetropolitan capital metropolitan areas policies 20 n=4,44 n444 44 (n=4,44 n=5,64 n564 64 (n=5,64 9 49. 151 47.151. 47151 471 47. 513 51. 47.1-51. 6 67. 569 65.569. 65569 655 65. 693 69. 65.5-69. n=4,4 n44 (n=4,4 n=5,6 n56 (n=5,6 15 47.151 4715 47.1-51 56 65.569 6556 65.5-69 n=4, n4 (n=4, n=5, n5 (n=5, 47.15 47.1-5 65.56 65.5-6 n=4 (n=4 n=5 (n=5 47.1- 65.5- n= (n= (n
Resumo Analisou-se a prevalência e fatores associados à realização da Triagem Neonatal Completa (TNC) entre crianças (<2 anos de idade) no Brasil incluídas na Pesquisa Nacional Saúde 2013 (n=4.442) e 2019 (n=5.643). Estudo transversal comparou as estimativas de prevalência e intervalos de confiança de 95% (IC95%) da TNC (testes do olhinho, orelhinha e pezinho). Diferenças foram consideradas estatisticamente significante ao nível de 5%. Regressões de Poisson bruta e ajustada foram realizadas para estimar Razões de Prevalência (RP) e IC95% para a associação das variáveis socioeconômicas, demográficas e de saúde com a TNC. Verificou-se aumento estatisticamente significante da TNC: 67,4% (IC95%: 65,5-69,3) em 2019, ante 49,2% (IC95%: 47,1-51,3) em 2013. Porém, ainda existem desigualdades e defasagens entre os estados da federação e variáveis sociodemográficas. Entre os anos, a TNC foi menor nas crianças de cor/raça parda e preta, dos três piores quintis de renda, sem plano de saúde, cadastradas na Estratégia de Saúde da Família, da região norte, de cidades do interior e da zona rural do Brasil. Apesar de o aumento da prevalência de TNC, desigualdades e defasagens individuais e contextuais permaneceram, indicando os desafios das políticas de saúde. Analisouse Analisou se (TNC <2 2 (< idade 201 n=4.442 n4442 n 4 442 (n=4.442 n=5.643. n5643 n=5.643 . 5 643 (n=5.643) 95 IC95 IC (IC95% testes olhinho pezinho. pezinho pezinho) 5% RP (RP socioeconômicas Verificouse Verificou 674 67 67,4 65,569,3 655693 65,5 69,3 65 69 3 65,5-69,3 492 49 49,2 47,151,3 471513 47,1 51,3 47 1 51 47,1-51,3 Porém sociodemográficas corraça cor raça preta renda Família norte permaneceram < ( 20 n=4.44 n444 44 (n=4.44 n564 n=5.64 64 (n=5.643 9 IC9 (IC95 6 67, 569 65,569, 65569 655 65, 693 69, 65,5-69, 49, 151 47,151, 47151 471 47, 513 51, 47,1-51, n=4.4 n44 (n=4.4 n56 n=5.6 (n=5.64 (IC9 56 65,569 6556 65,5-69 15 47,151 4715 47,1-51 n=4. n4 (n=4. n5 n=5. (n=5.6 (IC 65,56 65,5-6 47,15 47,1-5 n=4 (n=4 n=5 (n=5. 65,5- 47,1- n= (n= (n=5 (n
2.
Prevalência e fatores associados à realização dos exames de triagem neonatal no Brasil: comparação da PNS 2013 e 2019
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Melo, Wesley Soares de
; Brito, Leandro Cardozo dos Santos
; Oliveira, Bruno Luciano Carneiro Alves de
; Barbosa, Lorena Pinheiro
; Cardoso, Maria Vera Lúcia Moreira Leitão
.
Resumo Analisou-se a prevalência e fatores associados à realização da Triagem Neonatal Completa (TNC) entre crianças (<2 anos de idade) no Brasil incluídas na Pesquisa Nacional Saúde 2013 (n=4.442) e 2019 (n=5.643). Estudo transversal comparou as estimativas de prevalência e intervalos de confiança de 95% (IC95%) da TNC (testes do olhinho, orelhinha e pezinho). Diferenças foram consideradas estatisticamente significante ao nível de 5%. Regressões de Poisson bruta e ajustada foram realizadas para estimar Razões de Prevalência (RP) e IC95% para a associação das variáveis socioeconômicas, demográficas e de saúde com a TNC. Verificou-se aumento estatisticamente significante da TNC: 67,4% (IC95%: 65,5-69,3) em 2019, ante 49,2% (IC95%: 47,1-51,3) em 2013. Porém, ainda existem desigualdades e defasagens entre os estados da federação e variáveis sociodemográficas. Entre os anos, a TNC foi menor nas crianças de cor/raça parda e preta, dos três piores quintis de renda, sem plano de saúde, cadastradas na Estratégia de Saúde da Família, da região norte, de cidades do interior e da zona rural do Brasil. Apesar de o aumento da prevalência de TNC, desigualdades e defasagens individuais e contextuais permaneceram, indicando os desafios das políticas de saúde.
Abstract This study analyzed the prevalence of complete neonatal screening (CNS) of children aged under 2 years in Brazil and associated factors using data from the 2013 (n=4,442) and 2019 (n=5,643) national health surveys. We conducted a cross-sectional study to compare prevalence of CNS (eye, ear and heel prick tests) adopting 95% confidence intervals (95%CI) and a 5% significance level. Crude and adjusted Poisson regression was performed to estimate prevalence ratios (PR) and 95%CI to assess the association between socioeconomic, demographic and health variables and CNS. There was a statistically significant increase in CNS prevalence, from 49.2% (95%CI: 47.1-51.3) in 2013 to 67.4% (95%CI: 65.5-69.3) in 2019. However, large disparities persist across states and between sociodemographic groups. In both years, CNS prevalence was lowest among brown and black children, those from families in the three lowest income quintiles, children without health insurance, those from families registered in the Family Health Strategy and children living in the North, cities outside the state capital/metropolitan regions and rural areas. Despite the increase in prevalence of CNS, deep individual and contextual inequalities persist, posing challenges for health policies.
3.
Irregular practices in drugstores in the offer of products for children under three years old
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Soares, Roberta Almeida Silva
; Pinheiro, Elisa Natany Silva
; Diniz, Maria Hortência Teixeira
; Martins, Ana Paula Bortoletto
; Oliveira, Antônio Marcos Machado de
; Pereira, Leandro Alves
; Silva, Luciana Saraiva da
; Rinaldi, Ana Elisa Madalena
.
RESUMO Objetivo: Analisar a conformidade da comercialização dos produtos infantis incluídos na Norma Brasileira de Comercialização de Alimentos para Lactentes e Crianças de Primeira Infância, Bicos, Chupetas e Mamadeira (NBCAL) e de compostos lácteos em drogarias de Uberlândia/MG. Métodos: Estudo transversal realizado em 143 drogarias que vendiam produtos infantis: fórmulas infantis (FI) para lactentes, FI de seguimento para lactentes, mamadeiras, bicos, chupetas e protetores de mamilo; FI para crianças de primeira infância, alimentos de transição e alimentos à base de cereais, leites fluidos/em pó, leites modificados/similares de origem vegetal e composto lácteo. A localização das drogarias nos cinco setores geográficos foi realizada por geoprocessamento. Os dados coletados foram: tipos de promoção comercial irregular e tipo de administração da drogaria (rede/independente). As promoções comerciais irregulares foram expressas em frequências absoluta e relativa. Resultados: Verificamos a presença de promoção comercial irregular em 11,7% dos bicos, chupetas e mamadeiras, em 10,0% das FI lactentes/seguimento de lactentes, em 9,5% das FI para crianças de primeira infância, em 11,1% dos leites, em 25,0% de alimentos de transição e em 59,1% dos compostos lácteos. Nas drogarias de rede, a presença de promoção comercial irregular foi maior para compostos lácteos (81,8 vs. 28,6%, respectivamente) e, para leites, foi maior nas drogarias independentes (30,8 vs. 6,0%). Os setores central e leste apresentaram os maiores percentuais de promoção comercial irregular (26%). Conclusões: As violações à NBCAL ainda ocorrem nas drogarias, principalmente para os produtos destinados às crianças de primeira infância, e nas drogarias de rede. Objetivo Infância Bicos (NBCAL UberlândiaMG Uberlândia MG Uberlândia/MG Métodos 14 (FI lactentes mamadeiras bicos mamilo infância cereais fluidosem fluidos pó modificadossimilares modificados similares lácteo geoprocessamento rede/independente. redeindependente rede/independente . rede independente (rede/independente) relativa Resultados 117 11 7 11,7 100 10 0 10,0 lactentesseguimento 95 9 5 9,5 111 1 11,1 250 25 25,0 591 59 59,1 81,8 818 81 8 (81, vs 286 28 6 28,6% respectivamente 30,8 308 30 (30, 6,0%. 60 6,0% 6,0%) 26%. 26 26% (26%) Conclusões (rede/independente 11, 10, 9, 2 25, 59, 81, (81 28,6 30, 3 (30 6,0 (26% (8 28, (3 6, (26 ( (2
ABSTRACT Objective: To analyze the compliance with the commercialization of children's products included in the Brazilian Code of Marketing of Infant and Toddlers Food and Childcare-Related Products (NBCAL) in drugstores in Uberlândia/MG. Methods: A cross-sectional study was carried out in 143 drugstores that sold infant products: infant formula (IF), follow-up IF, nipples, teats, pacifiers and nipple shields; FI for young children, transition foods and cereal-based foods, fluid or powdered milk, modified/similar milks of plant origin and dairy compounds. The location of drugstores in the five geographic sectors was performed by geoprocessing. The data collected were: types of promotion and types of drugstore administration (drugstore chains/drugstores with independent administration). Irregular commercial promotion was expressed as absolute and relative frequencies. Results: Irregular commercial promotion was found in 11.7% of nipples, pacifiers and bottles, in 10.0% of IF and follow-up formula, in 9.5% of IF for young children, in 11.1% fluid or powdered milk, in 25.0% of transition foods and cereal-based foods and in 59.1% of dairy compounds. In commercial drugstore chains, the presence of promotion for dairy (81.8 vs. 28.6%, respectively) was higher than in drugstores with independent administration. The opposite ocurred for fluid or powdered milk, modified and similar milks of plant origin. The downtown and eastern sectors had the highest percentages of promotions (26%). Conclusions: NBCAL violations still occur in drugstores, mainly in the sale of young children's foods and in the commercial network drugstores. Objective childrens children s ChildcareRelated Childcare Related (NBCAL UberlândiaMG Uberlândia MG Uberlândia/MG Methods crosssectional cross sectional 14 , (IF) followup follow up nipples teats shields cerealbased cereal based milk modifiedsimilar compounds geoprocessing were chainsdrugstores chains . administration) frequencies Results 117 11 7 11.7 bottles 100 10 0 10.0 95 9 5 9.5 111 1 11.1 250 25 25.0 591 59 59.1 81.8 818 81 8 (81. vs 286 28 6 28.6% respectively 26%. 26 26% (26%) Conclusions (IF 11. 10. 9. 2 25. 59. 81. (81 28.6 (26% (8 28. (26 ( (2
4.
Isquemia de mão de pacientes em terapia renal substitutiva: avaliação por termografia substitutiva
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Miranda, Monica Karla Vojta
; Simplício, Irinéia de Oliveira Bacelar
; Bezerra, Jociléia da Silva
; Ferreira, Mariane Santos
; Lima, Fernanda da Silva
; Blandes, Antônia Irisley da Silva
; Simplício, Alessandra Tânara Corrêa
; Alves, Leandro Procópio
.
Abstract Objective To assess the presence of ischemia in the distal portion of the hands of the upper limbs with arteriovenous fistula (AVF) in patients undergoing renal replacement therapy (RRT) using infrared thermography. Method The sample consisted of 15 patients on RRT via hemodialysis using an AVF who answered a questionnaire prepared by the authors themselves with sociodemographic data, diagnosis, vital signs and data on AVF. To obtain thermograms of hands with and without AVF, a C5 infrared thermographic camera, FLIR Systems, was used, fixed 50 cm from participants’ hands, favoring bilateral framing of both hands. The data obtained were organized in an Excel 2011® spreadsheet and statistically compared using the Microcal Origin 6.0 program to assess whether there was a difference between temperature averages. Results Regarding sociodemographic variables, males were predominant, with a mean age of 45 years, (incomplete/complete) elementary school, married and from other municipalities. Thermography demonstrated that there is a difference in temperature between hands with AVF and without AVF, with a temperature variation of 1.78°C (± SD 1.99°C), lower for hands with AVF. Conclusion The analysis of hand blood distribution using thermography can provide evidence on peripheral microcirculation and guide the early diagnosis and treatment of AVF-induced ischemia in individuals undergoing RRT as an innovative auxiliary diagnostic tool for complications of venous access in hemodialysis patients. (AVF (RRT 1 C camera Systems used 5 participants 2011 60 6 0 6. averages variables predominant 4 years incomplete/complete incompletecomplete incomplete complete (incomplete/complete school municipalities 178C 78 ± ( 1.99°C, 199C 1.99°C , 99 1.99°C) AVFinduced induced 201 7 9 20 2
Resumo Objetivo Avaliar a presença de isquemia na porção distal das mãos dos membros superiores com Fistula Arteriovenosa (FAV) de pacientes em Terapia Renal Substitutiva (TRS) através da termografia por infravermelho. Método Amostra composta por 15 pacientes em TRS por hemodiálise por meio de FAV que responderam um questionário elaborado pelos próprios autores com as seguintes variáveis: dados sociodemográficos, diagnóstico, sinais vitais e dados sobre a FAV. Para obtenção dos termogramas das mãos com e sem FAV foi utilizado uma câmera termográfica por infravermelho C5, FLIR Systems, fixada a 50 cm das mãos dos participantes, privilegiando o enquadramento bilateral enquadrando ambas as mãos. Os dados obtidos foram organizados em planilha de Excel 2011® e comparados estatisticamente utilizando o programa Microcal Origin 6.0, para avaliar se existia diferença entre as médias de temperatura. Resultados Com relação as variáveis sociodemográficas, o gênero masculino foi o predominante, faixa etária com média de 45 anos, ensino fundamental (incompleto/completo), casados e provenientes de outros municípios. A termografia demonstrou que há diferença de temperatura entre as mãos com FAV e sem FAV, com variação na temperatura de 1,78°C (± DP 1,99°C), menor para as mãos com FAV. Conclusão A análise da distribuição do sangue das mãos por meio da termografia pode fornecer evidências sobre a microcirculação periférica e orientar o diagnóstico precoce e o tratamento da isquemia induzida por FAV em indivíduos em TRS, como ferramenta inovadora de diagnóstico auxiliar das complicações dos acessos venosos de pacientes em hemodiálise. (FAV (TRS 1 sociodemográficos C5 C Systems 5 participantes 2011 60 6 0 6.0 sociodemográficas predominante 4 anos incompleto/completo, incompletocompleto incompleto/completo , incompleto completo (incompleto/completo) municípios 178C 78 ± ( 1,99°C, 199C 1,99°C 99 1,99°C) 201 6. (incompleto/completo 7 9 20 2
Resumen Objetivo Evaluar la presencia de isquemia en la parte distal de las manos de los miembros superiores con fístula arteriovenosa (FAV) de pacientes en terapia de reemplazo renal (TRR) a través de la termografía infrarroja. Métodos Muestra compuesta por 15 pacientes en TRR por hemodiálisis mediante FAV que respondieron un cuestionario elaborado por los propios autores con las siguientes variables: datos sociodemográficos, diagnóstico, signos vitales y datos sobre la FAV. Para obtener los termogramas de las manos con y sin FAV, se utilizó una cámara termográfica infrarroja C5, FLIR Systems, ubicada a 50 cm de las manos de los participantes, favoreciendo el encuadramiento bilateral y encuadrando ambas manos. Los datos obtenidos se organizaron en una planilla de Excel 2011® y se compararon estadísticamente con el programa Microcal Origin 6.0, para evaluar si había diferencia entre los promedios de temperatura. Resultados Con relación a las variables sociodemográficas, el género masculino fue predominante, grupo de edad promedio de 45 años, educación primaria (incompleta/completa), casados y provenientes de otros municipios. La termografía demostró que hay diferencia de temperatura entre las manos con FAV y sin FAV, con una variación de temperatura de 1,78°C (± DP 1,99°C), menor en las manos con FAV. Conclusión El análisis de la distribución de la sangre de las manos por medio de termografía puede ofrecer evidencias sobre la microcirculación periférica y guiar el diagnóstico temprano y el tratamiento de la isquemia inducida por FAV en individuos en TRR, como una herramienta innovadora de diagnóstico auxiliar de las complicaciones de los accesos vasculares de pacientes en hemodiálisis. (FAV (TRR 1 sociodemográficos C5 C Systems 5 participantes 2011 60 6 0 6.0 sociodemográficas predominante 4 años incompleta/completa, incompletacompleta incompleta/completa , incompleta completa (incompleta/completa) municipios 178C 78 ± ( 1,99°C, 199C 1,99°C 99 1,99°C) 201 6. (incompleta/completa 7 9 20 2
5.
Chocolates Produced with Unroasted and Roasted Cocoa Beans: A Comparative Study of the Preservation of Bioactive Compounds Beans
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Onelli, Rebeca R. V.
; Jesus, Josane C. de
; Reis, Lucas C. C.
; Alves, Isabel C. S.
; Santos, Leandro S.
; Ferrão, Sibelli P. B.
.
The aim of the present study was to evaluate the effect of roasting and cocoa mass content on the composition of chocolates. Chocolate formulations were developed (40, 50, 60 and 70% cocoa solids) using unroasted and roasted cocoa beans, and analyses were performed: physicochemical, chemical composition, antioxidant capacity, procyanidin content, total phenolic compounds, quantification of theobromine, caffeine, catechin and epicatechin by high performance liquid chromatography (HPLC) and spectroscopic profile by mid-infrared spectroscopy (MIR). The results revealed that higher values of total phenolics, epicatechin and procyanidins, were obtained in chocolates produced with unroasted cocoa beans, with a significant difference in relation to those with roasted cocoa beans. It was observed that increasing the percentage of cocoa in the formulations caused an increase in the content of bioactive compounds. The use of MIR in the differentiation of chocolate samples produced with roasted and unroasted cocoa beans obtained a positive result. This technique associated with principal component analysis (PCA) enabled the separation of chocolates according to the type of cocoa bean (roasted and unroasted) used in production, confirming its importance for a quick evaluation of the parameters. 40, 40 (40 50 6 70 solids performed physicochemical capacity compounds theobromine caffeine HPLC (HPLC midinfrared mid infrared MIR. . (MIR) phenolics procyanidins result PCA (PCA production parameters 4 (4 5 7 (MIR (
6.
How can we reduce maternal mortality due to preeclampsia? The 4P rule preeclampsia P
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Korkes, Henri Augusto
; Cavalli, Ricardo Carvalho
; Oliveira, Leandro Gustavo De
; Ramos, José Geraldo Lopes
; Martins Costa, Sérgio Hofmeister de Almeida
; Sousa, Francisco Lázaro Pereira de
; Vieira da Cunha Filho, Edson
; de Souza Mesquita, Maria Rita
; Dias Corrêa Júnior, Mário
; Pinheiro Fernandes Araújo, Ana Cristina
; Zaconeta, Alberto Carlos Moreno
; Freire, Carlos Henrique Esteves
; Poli de Figueiredo, Carlos Eduardo
; Rocha Filho, Edilberto Alves Pereira da
; Sass, Nelson
; Peraçoli, José Carlos
; Costa, Maria Laura
.
Abstract In low and middle-income countries such as Brazil, most maternal deaths are related to hypertensive complications. Preeclampsia is the leading cause of maternal mortality and morbidity. Significant proportion is associated with the following factors: lack of identification of high-risk women, lack of adequate prevention, difficulty in maintaining a high-risk prenatal follow-up, delayed diagnosis, insecurity and low use of magnesium sulphate, delayed pregnancy interruption and lack of postpartum follow-up of these high-risk cases. Four major actions are proposed to minimize this alarming clinical picture and reduce the mortality rates due to preeclampsia, called the "4 P Rule" (Adequate Prevention – Vigilant Prenatal Care – Timely Delivery (Parturition) – Safe Postpartum). From this simple "rule" we can open a range of important processes and reminders that may help in the guidance of preeclampsia management. middleincome middle income Brazil complications morbidity factors highrisk high risk women prevention followup, followup follow up, up diagnosis sulphate cases 4 " Rule Adequate Parturition (Parturition Postpartum. Postpartum . Postpartum) rule "rule management
7.
Voice handicap and voice-related quality of life in COVID-19 patients voicerelated voice related COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Bueno, Lourival Mendes
; Ramos, Hugo Valter Lisboa
; Costa, Claudiney Cândido
; Alves, Wilder
; Velasco, Leandro Castro
; Biase, Noemi Grigoleto De
.
Abstract Objectives: Identifying voice handicap and voice-related quality of life in patients presenting pulmonary impairment associated with COVID-19 infection, comparing pulmonary parameters between these patients and individuals in the control group, as well as correlating pulmonary parameters to self-assessment questionnaires (IDV-10 and QVV). Methods: Thirty-five (35) patients presenting pulmonary impairment with COVID-19 infection were herein selected and compared to 35 individuals who were not affected by COVID-19 infection. Two self-assessment questionnaires were applied (vocal handicap index and voice quality of life protocol). Maximum phonation time Forced Expiratory Pressure (PEF) and Forced Inspiratory Pressure (PIF) were measured and videolaryngoscopy was performed. Results: There was statistically significant difference in scores recorded in voice self-assessment questionnaires (IDV-10 and QVV), Expiratory Pressure (PEF) and Forced Inspiratory Pressure (PIF) between patients with pulmonary impairment associated with COVID-19 infection and those in the control group. Correlation between PEF/PIF and scores recorded in voice self-assessment questionnaires was also observed. Conclusion: Pulmonary impairment associated with COVID-19 infection has worsened voice handicap and voice-related quality of life in the assessed patients, as well as reduced their forced expiratory and inspiratory pressure in comparison to the control group. Level of evidence: 4. Objectives voicerelated related COVID19 COVID 19 COVID-1 group selfassessment self assessment IDV10 IDV 10 (IDV-1 QVV. QVV . QVV) Methods Thirtyfive Thirty five (35 3 vocal protocol. protocol protocol) PEF (PEF PIF (PIF performed Results QVV, , PEFPIF observed Conclusion evidence 4 COVID1 1 COVID- IDV1 (IDV- (3 (IDV (
8.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
; Lucena, Carlos A.S. de
; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
; Dias, Cristina de O.
; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
; Toledo, Daniela G.P. de
; Takiya, Daniela M.
; Fernandes, Daniell R.R.
; Ament, Danilo C.
; Cordeiro, Danilo P.
; Silva, Darliane E.
; Pollock, Darren A.
; Muniz, David B.
; Gibson, David I.
; Nogueira, David S.
; Marques, Dayse W.A.
; Lucatelli, Débora
; Garcia, Deivys M.A.
; Baêta, Délio
; Ferreira, Denise N.M.
; Rueda-Ramírez, Diana
; Fachin, Diego A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Pádua, Diego G. de
; Barbosa, Diego N.
; Dolibaina, Diego R.
; Amaral, Diogo C.
; Chandler, Donald S.
; Maccagnan, Douglas H.B.
; Caron, Edilson
; Carvalho, Edrielly
; Adriano, Edson A.
; Abreu Júnior, Edson F. de
; Pereira, Edson H.L.
; Viegas, Eduarda F.G.
; Carneiro, Eduardo
; Colley, Eduardo
; Eizirik, Eduardo
; Santos, Eduardo F. dos
; Shimbori, Eduardo M.
; Suárez-Morales, Eduardo
; Arruda, Eliane P. de
; Chiquito, Elisandra A.
; Lima, Élison F.B.
; Castro, Elizeu B. de
; Orlandin, Elton
; Nascimento, Elynton A. do
; Razzolini, Emanuel
; Gama, Emanuel R.R.
; Araujo, Enilma M. de
; Nishiyama, Eric Y.
; Spiessberger, Erich L.
; Santos, Érika C.L. dos
; Contreras, Eugenia F.
; Galati, Eunice A.B.
; Oliveira Junior, Evaldo C. de
; Gallardo, Fabiana
; Hernandes, Fabio A.
; Lansac-Tôha, Fábio A.
; Pitombo, Fabio B.
; Dario, Fabio Di
; Santos, Fábio L. dos
; Mauro, Fabio
; Nascimento, Fabio O. do
; Olmos, Fabio
; Amaral, Fabio R.
; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
; Schmitz, Hermes J.
; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
; Quintino, Hingrid Y.S.
; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
; Franz, Ismael
; Fernandes, Itanna O.
; Golfetti, Ivan F.
; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
; Narita, João P.
; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
; Fernandes, Jose A.M.
; Pacheco, José F.
; Birindelli, José L.O.
; Rezende, José M.
; Avendaño, Jose M.
; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
; Pujol-Luz, José R.
; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
; Donahue, Julian P.
; Alvim, Juliana
; Almeida, Juliana C.
; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
; Kuabara, Kamila M.D.
; Nascimento, Karine B.
; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
; Miranda, Lucília S.
; Salik, Lucy M.
; Bezerra, Luis E.A.
; Silveira, Luis F.
; Campos, Luiz A.
; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
; Cruz, Luiza S. da
; Sekerka, Lukas
; Barros, Lurdiana D.
; Santos, Luziany Q.
; Skoracki, Maciej
; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
; Araújo, Marcel S. de
; Monné, Marcela L.
; Labruna, Marcelo B.
; Santis, Marcelo D. de
; Duarte, Marcelo
; Knoff, Marcelo
; Nogueira, Marcelo
; Britto, Marcelo R. de
; Melo, Marcelo R.S. de
; Carvalho, Marcelo R. de
; Tavares, Marcelo T.
; Kitahara, Marcelo V.
; Justo, Marcia C.N.
; Botelho, Marcia J.C.
; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
; Oliveira, Marcio L. de
; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
; Loeb, Marina V.
; Cohn-Haft, Mario
; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
; Rocha, Matheus dos S.
; Martins, Maurício L.
; Segura, Melissa O.
; Cardenas, Melissa Q.
; Duarte, Mércia E.
; Ivie, Michael A.
; Mincarone, Michael M.
; Borges, Michela
; Monné, Miguel A.
; Casagrande, Mirna M.
; Fernandez, Monica A.
; Piovesan, Mônica
; Menezes, Naércio A.
; Benaim, Natalia P.
; Reategui, Natália S.
; Pedro, Natan C.
; Pecly, Nathalia H.
; Ferreira Júnior, Nelson
; Silva Júnior, Nelson J. da
; Perioto, Nelson W.
; Hamada, Neusa
; Degallier, Nicolas
; Chao, Ning L.
; Ferla, Noeli J.
; Mielke, Olaf H.H.
; Evangelista, Olivia
; Shibatta, Oscar A.
; Oliveira, Otto M.P.
; Albornoz, Pablo C.L.
; Dellapé, Pablo M.
; Gonçalves, Pablo R.
; Shimabukuro, Paloma H.F.
; Grossi, Paschoal
; Rodrigues, Patrícia E. da S.
; Lima, Patricia O.V.
; Velazco, Paul
; Santos, Paula B. dos
; Araújo, Paula B.
; Silva, Paula K.R.
; Riccardi, Paula R.
; Garcia, Paulo C. de A.
; Passos, Paulo G.H.
; Corgosinho, Paulo H.C.
; Lucinda, Paulo
; Costa, Paulo M.S.
; Alves, Paulo P.
; Roth, Paulo R. de O.
; Coelho, Paulo R.S.
; Duarte, Paulo R.M.
; Carvalho, Pedro F. de
; Gnaspini, Pedro
; Souza-Dias, Pedro G.B.
; Linardi, Pedro M.
; Bartholomay, Pedro R.
; Demite, Peterson R.
; Bulirsch, Petr
; Boll, Piter K.
; Pereira, Rachel M.M.
; Silva, Rafael A.P.F.
; Moura, Rafael B. de
; Boldrini, Rafael
; Silva, Rafaela A. da
; Falaschi, Rafaela L.
; Cordeiro, Ralf T.S.
; Mello, Ramon J.C.L.
; Singer, Randal A.
; Querino, Ranyse B.
; Heleodoro, Raphael A.
; Castilho, Raphael de C.
; Constantino, Reginaldo
; Guedes, Reinaldo C.
; Carrenho, Renan
; Gomes, Renata S.
; Gregorin, Renato
; Machado, Renato J.P.
; Bérnils, Renato S.
; Capellari, Renato S.
; Silva, Ricardo B.
; Kawada, Ricardo
; Dias, Ricardo M.
; Siewert, Ricardo
; Brugnera, Ricaro
; Leschen, Richard A.B.
; Constantin, Robert
; Robbins, Robert
; Pinto, Roberta R.
; Reis, Roberto E. dos
; Ramos, Robson T. da C.
; Cavichioli, Rodney R.
; Barros, Rodolfo C. de
; Caires, Rodrigo A.
; Salvador, Rodrigo B.
; Marques, Rodrigo C.
; Araújo, Rodrigo C.
; Araujo, Rodrigo de O.
; Dios, Rodrigo de V.P.
; Johnsson, Rodrigo
; Feitosa, Rodrigo M.
; Hutchings, Roger W.
; Lara, Rogéria I.R.
; Rossi, Rogério V.
; Gerstmeier, Roland
; Ochoa, Ronald
; Hutchings, Rosa S.G.
; Ale-Rocha, Rosaly
; Rocha, Rosana M. da
; Tidon, Rosana
; Brito, Rosangela
; Pellens, Roseli
; Santos, Sabrina R. dos
; Santos, Sandra D. dos
; Paiva, Sandra V.
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; Oliveira, Sarah S. de
; Costa, Sávio C.
; Gardner, Scott L.
; Leal, Sebastián A. Muñoz
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; Stampar, Sérgio N.
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; Peck, Stewart B.
; Christo, Susete W.
; Cunha, Suzan B.Z.
; Gomes, Suzete R.
; Duarte, Tácio
; Madeira-Ott, Taís
; Marques, Taísa
; Roell, Talita
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; Sepulveda, Tatiana A.
; Maria, Tatiana F.
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; Rodrigues, Thaiana
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; Almeida, Thaís M. de
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; Trevine, Vivian
; Sousa, Viviane R.
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; Mathis, Wayne N.
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.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
9.
A ação jurídica e a emenda da consciência no Portugal dos Avis
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Abstract: In Portugal on the threshold of the 15th century, the Avis dynasty intensified the reform of customs not only within the court but also in various regions with the aim of establishing Christian parameters of conduct valid for nobles and other men. This was a policy reinforced by the actions of bishops interested in establishing criteria for action for clergy and laity based on constitutions promulgated in reformist synods. By juxtaposing impressions of members of the House of Avis with prescriptions of bishops, this article aims to examine the complementarity of monarchic and ecclesiastical actions in strengthening the inner forum, highlighting the authors of the first goal of the fifteenth century and the repercussions of their debates in works of the following decades. In other words, the aim is to analyze the power dynamics that defined the spaces for the amendment of conscience in the Portuguese kingdom of the fifteenth century. Abstract th men synods forum decades words
Resumo: No Portugal do limiar século XV, a dinastia de Avis intensificou a reforma de costumes não apenas no âmbito da corte, mas em diversas regiões com a finalidade de edificar parâmetros cristãos de conduta para os nobres e demais homens. Tratava-se de uma política reforçada pela atuação de bispos interessados em estabelecer critérios de ação para clérigos e leigos a partir de constituições promulgadas em sínodos reformistas. Cruzando impressões de membros da casa de Avis com diferentes prescrições de bispos, este artigo visa examinar a complementaridade das ações monárquicas e eclesiásticas no fortalecimento do foro interior com destaque a autores da primeira metade do quatrocentos e às repercussões de seus debates em obras das décadas seguintes. Mais precisamente, o alvo consiste em analisar os jogos de poder que definiram os espaços de emenda da consciência no reino português quatrocentista. Resumo XV corte homens Tratavase Tratava se reformistas seguintes precisamente quatrocentista
10.
Introdução da alimentação complementar e fatores associados em recém-nascidos pré-termo e com baixo peso: estudo de coorte prospectivo recémnascidos recém nascidos prétermo pré termo peso
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Pires, Priscilla Larissa Silva
; Romão, Rejane Sousa
; Souza, Rayany Cristina de
; Pereira, Leandro Alves
; Rinaldi, Ana Elisa Madalena
; Azevedo, Vivian Mara Gonçalves de Oliveira
.
This study aimed to analyze the association between sociodemographic factors, maternal and neonatal characteristics and the time taken to introduce complementary feeding in low birthweight and preterm newborns. This is a prospective cohort study of 79 preterm newborns weighing less than or equal to 1,800g. Data were collected at the time of hospital discharge and at the 6th, 9th ,and 12th months of corrected gestational age (CGA), using a structured questionnaire to analyze the time taken to introduce complementary feeding and the texture of the foods introduced. Furthermore, the Survey of Well-being of Young Children (SWYC-BR) was used to assess the risk of developmental delay. Cox proportional hazards regression was used to analyze the variables. The introduction of complementary feeding was assessed in preterm newborns based on the median age of introduction of liquid foods (3.50; IQR: 2.50-5.00), followed by solid (4.70; IQR: 3.20-5.20) and soft foods (5.00; IQR: 4.50-5.50). There was also an association with gestational age (RR = 1.25; 95%CI: 1.02-1.52) throughout the process of food introduction. For solid and soft foods, those with the longest length of stay (RR = 1.03; 95%CI: 1.10-1.05) and on mixed breastfeeding (RR = 2.97; 95%CI: 1.24-7.09) delayed the introduction of complementary feeding the longest. For liquid foods, less severe preterm newborns (Score for Neonatal Acute Physiology and Perinatal Extension - SNAPPE II [RR = 0.96; 95%CI: 0.94-0.98]) and mothers who were breastfeeding at hospital discharge (RR = 11.49; 95%CI: 1.57-84.10) delayed the introduction of complementary feeding. Guidelines are needed to better advise professionals and parents and/or guardians on the ideal time to introduce feeding. factors 7 1800g g 1 800g 1,800g 6th th CGA, CGA , (CGA) introduced Furthermore Wellbeing Well being SWYCBR SWYC BR (SWYC-BR delay variables 3.50 350 3 50 (3.50 IQR 2.505.00, 250500 2.50 5.00 2 5 00 2.50-5.00) 4.70 470 4 70 (4.70 3.205.20 320520 3.20 5.20 20 3.20-5.20 500 (5.00 4.505.50. 450550 4.50 5.50 . 4.50-5.50) RR 1.25 125 25 95%CI 95CI CI 95 1.021.52 102152 1.02 1.52 02 52 1.02-1.52 1.03 103 03 1.101.05 110105 1.10 1.05 10 05 1.10-1.05 2.97 297 97 1.247.09 124709 1.24 7.09 24 09 1.24-7.09 Score 0.96 096 0 96 0.940.98 094098 0.94 0.98 94 98 0.94-0.98] 11.49 1149 11 49 1.5784.10 1578410 1.57 84.10 57 84 1.57-84.10 andor (CGA 3.5 35 (3.5 505 2.505.00 25050 250 2.5 5.0 2.50-5.00 4.7 47 (4.7 205 3.205.2 32052 320 3.2 520 5.2 3.20-5.2 (5.0 4.505.50 45055 450 4.5 550 5.5 4.50-5.50 1.2 12 9 021 1.021.5 10215 102 1.0 152 1.5 1.02-1.5 101 1.101.0 11010 110 1.1 105 1.10-1.0 2.9 29 247 1.247.0 12470 124 709 7.0 1.24-7.0 0.9 940 0.940.9 09409 094 098 0.94-0.98 11.4 114 5784 1.5784.1 157841 157 8410 84.1 8 1.57-84.1 3. (3. 2.505.0 2505 2. 5. 2.50-5.0 4. (4. 3.205. 3205 32 3.20-5. (5. 4.505.5 4505 45 55 4.50-5.5 1. 1.021. 1021 15 1.02-1. 1.101. 1101 1.10-1. 1.247. 1247 7. 1.24-7. 0. 0.940. 0940 0.94-0.9 11. 578 1.5784. 15784 841 84. 1.57-84. (3 2.505. 2.50-5. (4 3.205 3.20-5 (5 4.505. 4.50-5. 1.021 1.02-1 1.101 1.10-1 1.247 1.24-7 0.940 0.94-0. 1.5784 1578 1.57-84 ( 2.505 2.50-5 3.20- 4.505 4.50-5 1.02- 1.10- 1.24- 0.94-0 1.578 1.57-8 2.50- 4.50- 0.94- 1.57-
O objetivo deste artigo foi analisar a associação entre os fatores sociodemográficos, as características maternas e neonatais e o tempo de introdução da alimentação complementar em recém-nascidos pré-termo e com baixo peso. Trata-se de um estudo de coorte prospectivo feito com 79 recém-nascidos pré-termo com peso menor ou igual a 1.800g. Os dados foram coletados no momento da alta hospitalar e ao 6º, 9º e 12º mês de idade gestacional corrigida (IGC), com auxílio de um questionário estruturado para analisar o tempo de introdução da alimentação complementar e texturas dos alimentos introduzidos. Além disso, para avaliar o risco de atraso de desenvolvimento, utilizou-se o Survey of Well-being of Young Children (SWYC-BR). Para análise das variáveis, aplicou-se regressão de riscos proporcionais de Cox. A introdução da alimentação complementar foi observada nos recém-nascidos pré-termo, com a mediana de idade de introdução de alimentos líquidos (3,50; IQ: 2,50-5,00), seguido por sólidos (4,70; IQ: 3,20-5,20) e pastosos (5,00; IQ: 4,50-5.50). Ainda, verificou-se associação da idade gestacional (RR = 1.25; IC95%: 1,02-1,52) em todo o processo da introdução alimentar. Para os alimentos sólidos e pastosos, aqueles com o maior tempo de internação (RR = 1,03; IC95%: 1,10- 1,05) e em amamentação mista (RR = 2,97; IC95%: 1,24-7,09) adiaram mais o tempo para introduzir a alimentação complementar. Para alimentos líquidos, recém-nascidos pré-termo menos graves (Score for Neonatal Acute Physiology and Perinatal Extension - SNAPPE II [RR = 0,96; IC95%: 0,94-0,98]) e mães que estavam amamentando na alta hospitalar (RR = 11,49; IC95%: 1,57-84,10) postergaram a introdução alimentar. Diretrizes para melhor orientação de profissionais e pais e/ou responsáveis sobre o momento ideal de introdução alimentar se faz necessário. sociodemográficos recémnascidos recém nascidos prétermo pré termo Tratase Trata 7 1800g g 1 800g 1.800g 6º º IGC, IGC , (IGC) introduzidos disso desenvolvimento utilizouse utilizou Wellbeing Well being SWYCBR. SWYCBR SWYC BR . (SWYC-BR) variáveis aplicouse aplicou Cox prétermo, termo, 3,50 350 3 50 (3,50 IQ 2,505,00, 250500 2,50 5,00 2 5 00 2,50-5,00) 4,70 470 4 70 (4,70 3,205,20 320520 3,20 5,20 20 3,20-5,20 500 (5,00 4,505.50. 450550 4,50 5.50 4,50-5.50) Ainda verificouse verificou RR 1.25 125 25 IC95% IC95 IC 1,021,52 102152 1,02 1,52 02 52 1,02-1,52 1,03 103 03 1,10 110 10 1,05 105 05 2,97 297 97 1,247,09 124709 1,24 7,09 24 09 1,24-7,09 Score 0,96 096 0 96 0,940,98 094098 0,94 0,98 94 98 0,94-0,98] 11,49 1149 11 49 1,5784,10 1578410 1,57 84,10 57 84 1,57-84,10 eou necessário (IGC (SWYC-BR 3,5 35 (3,5 505 2,505,00 25050 250 2,5 5,0 2,50-5,00 4,7 47 (4,7 205 3,205,2 32052 320 3,2 520 5,2 3,20-5,2 (5,0 4,505.50 45055 450 4,5 550 5.5 4,50-5.50 1.2 12 IC9 021 1,021,5 10215 102 1,0 152 1,5 1,02-1,5 1,1 2,9 29 9 247 1,247,0 12470 124 1,2 709 7,0 1,24-7,0 0,9 940 0,940,9 09409 094 098 0,94-0,98 11,4 114 5784 1,5784,1 157841 157 8410 84,1 8 1,57-84,1 3, (3, 2,505,0 2505 2, 5, 2,50-5,0 4, (4, 3,205, 3205 32 3,20-5, (5, 4,505.5 4505 45 55 5. 4,50-5.5 1. 1,021, 1021 1, 15 1,02-1, 1,247, 1247 7, 1,24-7, 0, 0,940, 0940 0,94-0,9 11, 578 1,5784, 15784 841 84, 1,57-84, (3 2,505, 2,50-5, (4 3,205 3,20-5 (5 4,505. 4,50-5. 1,021 1,02-1 1,247 1,24-7 0,940 0,94-0, 1,5784 1578 1,57-84 ( 2,505 2,50-5 3,20- 4,505 4,50-5 1,02- 1,24- 0,94-0 1,578 1,57-8 2,50- 4,50- 0,94- 1,57-
El objetivo de este estudio fue analizar la asociación entre los factores sociodemográficos, características maternas y neonatales y el momento de introducción de la alimentación complementaria en recién nacidos pretérmino (recém-nascidos pré-termo) y de bajo peso. Se trata de un estudio de cohorte prospectivo realizado con 79 recém-nascidos pré-termo con un peso menor o igual a 1.800g. Los datos se recopilaron en el momento del alta hospitalaria y al 6º, 9º y 12º mes de edad gestacional corregida (EGC), con la ayuda de un cuestionario estructurado para analizar el momento de introducción de la alimentación complementaria y las texturas de los alimentos introducidos. Además, para evaluar el riesgo de retraso en el desarrollo, se utilizó la Survey of Well-being of Young Children (SWYC-BR). Para analizar las variables, se aplicó la regresión de riesgos proporcionales de Cox. La introducción de la alimentación complementaria se observó en los recém-nascidos pré-termo, con la mediana de edad de introducción de alimentos líquidos (3,50; IIC: 2,50-5,00), seguido de los sólidos (4,70; IIC: 3,20-5,20) y pastosos (5,00; IIC: 4,50-5,50). Además, se constató la asociación de la edad gestacional (RR = 1,25; IC95%: 1,02-1,52) durante todo el proceso de introducción alimentaria. En el caso de alimentos sólidos y pastosos, aquellos con mayor tiempo de hospitalización (RR = 1,03; IC95%: 1,10-1,05) y en lactancia mixta (RR = 2,97; IC95%: 1,24-7,09) retrasaron más la introducción de alimentación complementaria. En el caso de alimentos líquidos, los recém-nascidos pré-termo menos graves (Score for Neonatal Acute Physiology and Perinatal Extension - SNAPPE II [RR = 0,96; IC95%: 0,94-0,98]) y las madres que estaban amamantando al alta hospitalaria (RR = 11,49; IC95%: 1,57-84,10) pospusieron la introducción de alimentos. Se hacen necesarias pautas para una mejor orientación a profesionales y padres o tutores sobre el momento ideal para la introducción alimentaria. sociodemográficos recémnascidos recém nascidos prétermo pré termo 7 1800g g 1 800g 1.800g 6º º EGC, EGC , (EGC) introducidos Además desarrollo Wellbeing Well being SWYCBR. SWYCBR SWYC BR . (SWYC-BR) variables Cox prétermo, termo, 3,50 350 3 50 (3,50 IIC 2,505,00, 250500 2,50 5,00 2 5 00 2,50-5,00) 4,70 470 4 70 (4,70 3,205,20 320520 3,20 5,20 20 3,20-5,20 500 (5,00 4,505,50. 450550 4,50 5,50 4,50-5,50) RR 1,25 125 25 IC95% IC95 IC 1,021,52 102152 1,02 1,52 02 52 1,02-1,52 alimentaria 1,03 103 03 1,101,05 110105 1,10 1,05 10 05 1,10-1,05 2,97 297 97 1,247,09 124709 1,24 7,09 24 09 1,24-7,09 Score 0,96 096 0 96 0,940,98 094098 0,94 0,98 94 98 0,94-0,98] 11,49 1149 11 49 1,5784,10 1578410 1,57 84,10 57 84 1,57-84,10 (EGC (SWYC-BR 3,5 35 (3,5 505 2,505,00 25050 250 2,5 5,0 2,50-5,00 4,7 47 (4,7 205 3,205,2 32052 320 3,2 520 5,2 3,20-5,2 (5,0 4,505,50 45055 450 4,5 550 5,5 4,50-5,50 1,2 12 IC9 021 1,021,5 10215 102 1,0 152 1,5 1,02-1,5 101 1,101,0 11010 110 1,1 105 1,10-1,0 2,9 29 9 247 1,247,0 12470 124 709 7,0 1,24-7,0 0,9 940 0,940,9 09409 094 098 0,94-0,98 11,4 114 5784 1,5784,1 157841 157 8410 84,1 8 1,57-84,1 3, (3, 2,505,0 2505 2, 5, 2,50-5,0 4, (4, 3,205, 3205 32 3,20-5, (5, 4,505,5 4505 45 55 4,50-5,5 1, 1,021, 1021 15 1,02-1, 1,101, 1101 1,10-1, 1,247, 1247 7, 1,24-7, 0, 0,940, 0940 0,94-0,9 11, 578 1,5784, 15784 841 84, 1,57-84, (3 2,505, 2,50-5, (4 3,205 3,20-5 (5 4,505, 4,50-5, 1,021 1,02-1 1,101 1,10-1 1,247 1,24-7 0,940 0,94-0, 1,5784 1578 1,57-84 ( 2,505 2,50-5 3,20- 4,505 4,50-5 1,02- 1,10- 1,24- 0,94-0 1,578 1,57-8 2,50- 4,50- 0,94- 1,57-
11.
Leishmania spp. genetic factors associated with cutaneous leishmaniasis antimony pentavalent drug resistance: a systematic review spp resistance
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Nery, Raphaela Lisboa Andrade
; Santos, Thaline Mabel Sousa
; Gois, Luana Leandro
; Barral, Aldina
; Khouri, Ricardo
; Feitosa, Caroline Alves
; Santos, Luciane Amorim
.
BACKGROUND Leishmaniasis is a neglected zoonosis caused by parasites of Leishmania spp. The main drug used to treat cutaneous leishmaniasis (CL) is the antimoniate of meglumine. This drug, which has strong adverse and toxic effects, is usually administered intravenously, further complicating the difficult treatment. Factors such as Leishmania gene expression and genomic mutations appear to play a role in the development of drug resistance. OBJECTIVES This systematic review summarises the results of the literature evaluating parasite genetic markers possibly associated with resistance to pentavalent antimony in CL. METHODS This study followed PRISMA guidelines and included articles from PubMed, SciELO, and LILACS databases. Inclusion criteria were studies that (i) investigated mutations in the genome and/or changes in gene expression of Leishmania associated with treatment resistance; (ii) used antimony drugs in the therapy of CL; (iii) used naturally resistant strains isolated from patients. The Joanna Briggs Institute Critical Appraisal Checklist was used to assess article quality and risk of bias. FINDINGS A total of 23 articles were selected, of which 18 investigated gene expression and nine genomic mutations. Of these 23 articles, four examined gene expression and genomic mutations in the same samples. Regarding gene expression, genes from the ABC transporter protein family, AQP1, MRPA, TDR1 and TRYR were most frequently associated with drug resistance. In one of the articles in which mutations were investigated, a mutation was found in HSP70 (T579A) and in three articles mutations were found in AQP1 (A516C, G562A and G700A). A limitation of this review is that in most of the included studies, parasites were isolated from cultured lesion samples and drug resistance was assessed using in vitro drug susceptibility testing. These approaches may not be ideal for accurate genetic evaluation and detection of treatment failure. MAIN CONCLUSIONS The development of further studies to evaluate the genetic resistance factors of Leishmania spp. is necessary to elucidate the mechanisms of the parasite and improve patient treatment and infection control. spp CL (CL meglumine effects intravenously PubMed SciELO databases i (i andor or ii (ii iii (iii patients bias 2 selected 1 family AQP MRPA TDR HSP HSP7 T579A TA T (T579A A516C, A516C AC C (A516C GA G G700A. G700A . G700A) testing failure control
12.
Face mask use and viral load in patients with mild symptoms of COVID-19 COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Costa, Murilo Soares
; Alves, Claudia Regina Lindgren
; Fonseca, Flávio Guimarães da
; Sato, Hugo Itaru
; Rocha, Raissa Prado
; Carvalho, Alex Fiorini de
; Lourenço, Karine Lima
; Guimarães, Nathalia Sernizon
; Machado, Elaine Leandro
; Teixeira, Santuza Maria Ribeiro
; Tupinambás, Unaí
; Takahashi, Ricardo Hiroshi Caldeira
.
ABSTRACT Objective: Previous studies indicated that face masks reduce the probability of infection by SARS-CoV-2 but did not examine the relationship between SARS-CoV-2 viral load and mask usage. This study analyzed this relationship. Methods: This cross-sectional study evaluated patients admitted to a public Emergency Care Unit in Belo Horizonte, MG, Brazil, between October 2020 and March 2021. Convenience samples were recruited during the study period. Adult patients with COVID-19 symptoms were invited to participate after being examined by a physician according to the Emergency Care Unit routine. This study included 441 adults with mild symptoms diagnosed with COVID-19 via RT-PCR, who were tested until the 14th day after symptom onset. Participants were interviewed about mask usage, oropharyngeal swabs were collected, and the SARS-CoV-2 viral load was measured using RT-PCR. The difference between the SARS-CoV-2 viral load in the groups of individuals who regularly used and did not use masks was subjected to a hypothesis test. Results: Of the patients who had swabs collected 1-5 days after symptom onset, 64.9% of those not using masks regularly and 45.5% of those using masks regularly presented a high SARS-CoV-2 viral load. This difference was statistically significant (p=0.0073). Considering only the patients who had swabs collected 4-8 days after symptom onset, 44.1% of those not using masks regularly and 30.8% of those using masks regularly presented a high SARS-CoV-2 viral load; this difference was statistically significant (p=0.0364). Conclusion: When people who regularly wear a face mask contract COVID-19, they have a significantly lower probability of having a high viral load of SARS-CoV-2 compared to those who do not regularly wear masks. Objective SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- usage Methods crosssectional cross sectional Horizonte MG Brazil 202 2021 period COVID19 COVID 19 COVID-1 routine 44 RTPCR, RTPCR RT PCR, PCR RT-PCR th onset RTPCR. PCR. test Results 15 1 5 1- 649 64 9 64.9 455 45 45.5 p=0.0073. p00073 p p=0.0073 . 0 0073 (p=0.0073) 48 4 8 4- 44.1 308 30 30.8 p=0.0364. p00364 p=0.0364 0364 (p=0.0364) Conclusion COVID19, 19, SARS-CoV 20 COVID1 COVID- 6 64. 45. p0007 p=0.007 007 (p=0.0073 44. 3 30. p0036 p=0.036 036 (p=0.0364 p000 p=0.00 00 (p=0.007 p003 p=0.03 03 (p=0.036 p00 p=0.0 (p=0.00 (p=0.03 p0 p=0. (p=0.0 p=0 (p=0. p= (p=0 (p= (p
13.
“Whoa, But I’m Not Like This, I Don’t Even Know How This Happens”: Literacy Practices and Experiences of Students From Migrant Backgrounds in a Brazilian Public University Whoa, Whoa “Whoa Im m Dont Don t Happens Happens”
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ABSTRACT: This article discusses the literacy practices and experiences of four students from migrant backgrounds who entered a federal public university in Brazil through a public call specifically designed for this group. In the field of Critical Applied Linguistics, we take a decolonial stance on internationalization and academic literacies. Research data were generated using tools such as questionnaires, semi-structured interviews, and WhatsApp. The analysis focused on three main aspects: (i) ‘mismatches’ between the participants’ expectations and the curricular structure of their undergraduate courses; (ii) the opacity of certain aspects of academic literacy and curricular organization; (iii) issues related to identity in interaction with peers. The research findings point to the ways in which language education policies can be developed with a view to promoting inclusion in higher education for students from migrant backgrounds. ABSTRACT group Linguistics literacies questionnaires semistructured semi structured interviews WhatsApp i (i ‘mismatches mismatches participants courses ii (ii organization iii (iii peers
RESUMO: Este artigo discute práticas de letramento e experiências de quatro estudantes migrantes de crise que ingressaram em uma universidade pública federal no Brasil por meio de um edital específico para esse público. Filiando-nos ao campo indisciplinar da Linguística Aplicada Crítica, assumimos uma perspectiva decolonial sobre internacionalização e letramentos acadêmicos. Os registros de pesquisa foram gerados por ferramentas como questionários, entrevistas semiestruturadas e WhatsApp. A análise dos dados se centrou em três aspectos principais: (i) desencontros entre as expectativas dos participantes e a estrutura curricular de seus cursos de graduação; (ii) a opacidade de certos aspectos do letramento acadêmico e da organização curricular; (iii) questões relacionadas a processos identitários na interação com pares. Os resultados da pesquisa indicam maneiras como as políticas linguísticas educacionais podem ser desenvolvidas com vistas a promover a inserção de estudantes migrantes de crise no ensino superior. RESUMO público Filiandonos Filiando nos Crítica acadêmicos questionários WhatsApp principais i (i graduação ii (ii iii (iii pares superior
14.
Oral cancer and prosthetic rehabilitation: how,he patient reacts? rehabilitation howhe how he reacts
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Oliveira, Emily Nogueira
; Campos Filho, Márcio Leandro Arruda
; Soares Lopes, Maria Carolina
; Santos, Thiago Alves Xavier dos
; Pereira, Wilson Vicente Souza
; Bezerra Junior, Maximino Alencar
.
ABSTRACT Objective: The aim of this study was to evaluate the comprehension of dental practitioners regarding the complexities encountered by patients undergoing prosthetic rehabilitation following oral cancer surgery. Methods: This research employed a descriptive-quantitative approach. The study population comprised 37 dentists representing various specialized fields located in Montes Claros, Minas Gerais, Brazil. Data were gathered through an online semi-structured questionnaire designed to elicit insights into the knowledge and perceptions of these professionals pertaining to prosthetic rehabilitation in post-oral cancer surgery patients. Results: The results indicated that 75.7% of the participants reported a high level of patient satisfaction with prosthetic treatment. Notable improvements were observed in mastication (94.6%), respiration (35.1%), oral muscle function (48.6%), phonation (56.8%), overall health (59.5%), self-esteem (100.0%), and occlusion (62.2%). Furthermore, the presence of a multidisciplinary healthcare team for managing these patients was noted. Conclusion: In conclusion, it can be inferred that dentists possess a comprehensive understanding of the diverse challenges confronted by patients in the context of prosthetic rehabilitation following oral oncologic surgery. Additionally, the study underscores the pivotal role of prosthetic rehabilitation in enhancing patients’ functional abilities, aesthetics, and overall comfort. Objective Methods descriptivequantitative descriptive quantitative approach 3 Claros Gerais Brazil semistructured semi structured postoral post Results 757 75 7 75.7 treatment 94.6%, 946 94.6% , 94 6 (94.6%) 35.1%, 351 35.1% 35 1 (35.1%) 48.6%, 486 48.6% 48 (48.6%) 56.8%, 568 56.8% 56 8 (56.8%) 59.5%, 595 59.5% 59 5 (59.5%) selfesteem self esteem 100.0%, 1000 100.0% 100 0 (100.0%) 62.2%. 622 62.2% . 62 2 (62.2%) Furthermore noted Conclusion conclusion Additionally abilities aesthetics comfort 75. 94.6 9 (94.6% 35.1 (35.1% 48.6 4 (48.6% 56.8 (56.8% 59.5 (59.5% 100.0 10 (100.0% 62.2 (62.2% 94. (94.6 35. (35.1 48. (48.6 56. (56.8 59. (59.5 100. (100.0 62. (62.2 (94. (35. (48. (56. (59. (100. (62. (94 (35 (48 (56 (59 (100 (62 (9 (3 (4 (5 (10 (6 ( (1
RESUMO Objetivo: avaliar se os cirurgiões dentistas compreendem os desafios que os pacientes têm acerca da reabilitação protética pós cirurgia oncológica bucal. Métodos: trata-se de um estudo de caráter descritivo-quantitativo. A população foi composta por 37 cirurgiões dentistas de diversas especialidades na cidade de Montes Claros – Minas Gerais, Brazil. A coleta de dados se deu através de um questionário semiestruturado online buscando informações sobre conhecimento e percepção desses profissionais sobre a reabilitação protética em pacientes pós cirurgia oncológica bucal. Resultados: nota-se que, 75,7% dos participantes relataram que a maioria dos pacientes se sentiram satisfeitos com o tratamento protético, entre as melhorias, destacam-se, mastigação (94,6%), respiração (35,1%), músculos bucais (48,6%), voz (56,8%), saúde (59,5%), autoestima (100,0%) e mordida (62,2%). Além disso, observou-se a presença de uma equipe multiprofissional para tratamento desse paciente. Conclusão: conclui-se que os cirurgiões dentistas compreendem os diversos desafios enfrentados pelos pacientes em relação à reabilitação protética pós cirurgia oncológica bucal e ainda observa-se a importância de que essa reabilitação tem para os pacientes para que haja o desenvolvimento das funções, estética e conforto do paciente. Objetivo Métodos tratase trata descritivoquantitativo. descritivoquantitativo descritivo quantitativo. quantitativo descritivo-quantitativo 3 Gerais Brazil Resultados notase nota 757 75 7 75,7 protético melhorias destacamse, destacamse destacam se, destacam-se 94,6%, 946 94,6% , 94 6 (94,6%) 35,1%, 351 35,1% 35 1 (35,1%) 48,6%, 486 48,6% 48 (48,6%) 56,8%, 568 56,8% 56 8 (56,8%) 59,5%, 595 59,5% 59 5 (59,5%) 100,0% 1000 100 0 (100,0% 62,2%. 622 62,2% . 62 2 (62,2%) disso observouse observou paciente Conclusão concluise conclui observase observa funções 75, 94,6 9 (94,6% 35,1 (35,1% 48,6 4 (48,6% 56,8 (56,8% 59,5 (59,5% 100,0 10 (100,0 62,2 (62,2% 94, (94,6 35, (35,1 48, (48,6 56, (56,8 59, (59,5 100, (100, 62, (62,2 (94, (35, (48, (56, (59, (100 (62, (94 (35 (48 (56 (59 (10 (62 (9 (3 (4 (5 (1 (6 (
15.
Fatores de Risco, Manejo e Evolução após Primeiro Infarto Agudo do Miocárdio: Um Estudo de Mundo Real Comparando Coortes de Mulheres e Homens na Rede TriNetX Risco Miocárdio
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Guida, Camila Mota
; Souza, Eduardo Juvenal de
; Costa, Leandro Menezes Alves da
; Scudeler, Thiago Luis
; Nunes, Rafael Amorim Belo
; Oliveira, Gustavo Bernardes de Figueiredo
.
Abstract Background: International cohort studies have consistently demonstrated an unfavorable prognosis in female patients after the first acute myocardial infarction (AMI) over the past decades. However, national data on this topic are limited. Objectives: This study aims to compare national cohorts of men and women hospitalized due to the first acute myocardial infarction, examining long-term outcomes. Methods: A retrospective, observational study using real-world data extracted from the global TriNetX platform, including patients of both sexes with a confirmed diagnosis of AMI according to the International Classification of Diseases (ICD), version 11, code I21. The level of statistical significance adopted in the analysis was 5% (0.05). The primary outcome assessed was a composite of death, new hospitalization for AMI, myocardial revascularization procedures, or heart failure after the hospital phase with a 5-year follow-up. Results: Data from 29,041 patients were evaluated, of which 11,284 (38.4%) were women. The mean age of the female and male populations was 64.4 and 59.8 years, respectively. The group of women showed a higher occurrence of the composite outcome of death, new hospitalization for AMI, myocardial revascularization procedures, or heart failure after the hospital phase with a 5-year follow-up (OR 1.058; CI 1.005 - 1.113; p = 0.03). Conclusions: In this large Brazilian cohort, the female sex was associated with a higher occurrence of cardiovascular events within 5 years after hospital discharge. Background (AMI decades However limited Objectives longterm long term outcomes Methods retrospective realworld real world platform ICD, ICD , (ICD) 11 I21 I 0.05. 005 0.05 . 0 05 (0.05) death procedures 5year year followup. followup follow up. up Results 29041 29 041 29,04 evaluated 11284 284 11,28 38.4% 384 38 4 (38.4% 644 64 64. 598 59 8 59. respectively OR 1.058 1058 1 058 1005 1.00 1.113 1113 113 0.03. 003 0.03 03 0.03) Conclusions discharge (ICD I2 00 0.0 (0.05 2904 2 04 29,0 1128 28 11,2 38.4 3 (38.4 6 1.05 105 100 1.0 1.11 111 0. (0.0 290 29, 112 38. (38. 10 1. 1.1 (0. (38 (0 (3 (
Resumo Fundamento: Estudos de coorte internacionais têm consistentemente demonstrado ao longo das últimas décadas um prognóstico desfavorável em pacientes do sexo feminino após o primeiro infarto agudo do miocárdio. No entanto, dados nacionais sobre esse tema são limitados. Objetivos: O presente estudo tem como objetivo comparar coortes nacionais de homens e mulheres hospitalizados devido ao primeiro infarto agudo do miocárdio (IAM), examinando os desfechos a longo prazo. Métodos: Estudo retrospectivo, observacional, com dados de mundo real extraídos da plataforma global TriNetX, incluindo pacientes de ambos os sexos com diagnóstico confirmado de IAM por classificação internacional de doenças (CID), versão 11, código I21. O nível de significância estatística adotado na análise foi de 5% (0,05). O desfecho primário avaliado foi composto por óbito, nova hospitalização por IAM, procedimentos de revascularização miocárdica, ou insuficiência cardíaca após fase hospitalar e com seguimento de 5 anos. Resultados: Foram avaliados dados de 29.041 pacientes, dos quais 11.284 (38,4%) eram mulheres. A idade média das populações feminina e masculina foi, respectivamente, 64,4 e 59,8 anos. O grupo de mulheres apresentou maior ocorrência do desfecho combinado de óbito, nova hospitalização por IAM, procedimentos de revascularização miocárdica, ou insuficiência cardíaca após fase hospitalar e com seguimento de 5 anos (OR 1.058; IC 1.005 - 1.113; p = 0,03). Conclusão: Nesta grande coorte brasileira, o sexo feminino foi associado a maior ocorrência de eventos cardiovasculares em período de 5 anos após a alta hospitalar. Fundamento entanto limitados Objetivos , (IAM) prazo Métodos retrospectivo observacional TriNetX CID, CID (CID) 11 I21 I 0,05. 005 0,05 . 0 05 (0,05) óbito miocárdica Resultados 29041 29 041 29.04 11284 284 11.28 38,4% 384 38 4 (38,4% respectivamente 644 64 64, 598 59 8 59, OR 1.058 1058 1 058 1005 1.00 1.113 1113 113 0,03. 003 0,03 03 0,03) Conclusão brasileira (IAM (CID I2 00 0,0 (0,05 2904 2 04 29.0 1128 28 11.2 38,4 3 (38,4 6 1.05 105 100 1.0 1.11 111 0, (0,0 290 29. 112 11. 38, (38, 10 1. 1.1 (0, (38 (0 (3 (
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