Abstract Background In contemporary society, with the accelerated pace of work and life, more and more people feel different degrees of stress. Long-term stress may not only lead to insomnia, but also to mental health problems (e.g., anxiety and depression), which has a significant impact on people's quality of life and mental health. Objective This study primarily investigates the mechanism through which stress affects sleep quality among college students. Methods We conducted research on 1653 Chinese college students using four scales with high reliability and validity: stress, the Pittsburgh Sleep Quality Index, social anxiety, and rumination. Results The study found: (1) Stress can significantly and positively predict sleep quality and rumination; (2) Rumination can positively predict social anxiety; (3) Social anxiety can positively predict sleep quality; (4) Stress can affect sleep quality through social anxiety and rumination separately, and stress can also affect sleep quality through the chained mediation of rumination and social anxiety. Conclusion This study reveals the relationship and mechanisms between stress and sleep quality. It not only deepens the research on the impact of stress on sleep quality but also provides theoretical support and new methods for mental health professionals to help clients improve their sleep quality. In practice, in addition to using some common psychological intervention methods to help individuals reduce stress, we should pay more attention to how to help clients reduce rumination and social anxiety, This is significant in improving the quality of an individual's sleep. society Longterm Long term insomnia e.g., eg e g (e.g. depression, depression , depression) peoples s 165 validity Index found 1 (1 2 (2 3 (3 4 (4 separately practice individual e.g. (e.g 16 ( e.g

Abstract Fast calculations are widely required in the traditional applications and the emerging digital twin fields. For those considerations, a novel physics-based fast algorithm, namely generalized rotation-superposition method, is proposed for fast calculating linear elastic responses of generalized rotationally axisymmetric structures under arbitrary mechanical loads. This improved method breaks through the limitations of the previous basic rotation-superposition method in rotational similarity of load and structural axisymmetry, and greatly expands its application scope. In this paper, firstly, the basic theory of the rotation-superposition algorithm is introduced; secondly, the theoretical model of the generalized rotation-superposition method is established; thirdly, the effectiveness and accuracy are verified by using finite element simulations; finally, through a complex case study, the applicability of the generalized rotation-superposition method for complex engineering problems and its advantages in efficiently obtaining massive amounts of data are further illustrated. fields considerations physicsbased physics based rotationsuperposition rotation superposition loads axisymmetry scope paper firstly introduced secondly established thirdly simulations finally study illustrated

Abstract Objective: Aortic Dissection (AD) is one of the most fatal acute diseases in cardiovascular diseases, with rapid onset and progression and a high fatality rate. This study aims to investigate the clinical values of non-enhancement peripheral pulse-gating rapid magnetic resonance imaging in deterministic diagnosis of AD. Methods: Aorta magnetic resonance imaging was performed in 21 healthy volunteers at a 1.5t MR scanner sequences including cardiac-gated and peripheral pulse-gated True-FISP and HASTE were carried out separately. Acquisition Time (TA), Signal to Noise Ratio (SNR), Contrast Noise Ratio (CNR), and entirety of vessel wall blood flow artifacts were measured and compared. A total of 56 AD cases were displayed by non-enhancement peripheral pulse-gating fast MR imaging, and the results were compared with pathological findings or CTA of the aorta. The dissection rupture, tear film, true and false lumen, thrombosis, hydropericardium, and the main branches of AD were evaluated respectively. Results: There were no significant differences in SNR, CNR, entirety of the vessel wall, and blood flow artifact between cardiac-gated and peripheral pulse-gated fast MR imaging. Non-enhancement pulse-gated fast scanning takes less TA time. By the pulse-gated non-enhancement fast MR imaging, the dissection rupture, tear film, true and false cavity, thrombosis, hydropericardium, and the main branches of aortic dissection were shown clearly. Multi-planar and multi-angle scans helped to show the extent of entrapment rupture, whereas partial complex tears or bi-directional tears were slightly less well visualized. Conclusion: Non-enhancement peripheral pulse-gated rapid magnetic resonance imaging can be used for deterministic diagnosis of AD. Objective (AD rate nonenhancement non enhancement pulsegating pulse gating Methods 2 15t t 1 5t cardiacgated cardiac gated pulsegated TrueFISP True FISP separately TA, , (TA) SNR (SNR) CNR (CNR) 5 aorta rupture film lumen thrombosis hydropericardium respectively Results Nonenhancement Non time cavity clearly Multiplanar Multi planar multiangle multi angle bidirectional bi directional visualized Conclusion (TA (SNR (CNR

Abstract Introduction: Propofol is a widely used anesthetic and its dose is closely related to aging. Telomere length (TL) is a unique heritable trait, and emerging as a biomarker of aging, health and disease. Telomerase RNA component (TERC) plays an important role in maintaining TL. We proposed a hypothesis that propofol dose in general anesthesia can be predicted by measuring TL before operation, which greatly reduced the risk of anesthesia, especially the elderly. Methods: The association between the propofol dose in anesthesia induction and: TL in the DNA of peripheral blood leukocytes; body weight; sex; difference of the Bispectral Index (BIS) before and after anesthesia induction in patients was evaluated by multivariable linear regression analyses. The mutation at the 5’end or 3’end of TERC was detected. We recruited 100 patients of elective surgery. Results: We found that propofol dose in anesthesia induction was clearly correlated significantly with TL (r = 0.78, p < 0.001), body weight (r = 0.84, p = 0.004), sex (r = 0.83, p= 0.84, p = 0.004), sex (r = 0.83, p = 0.004), and difference of BIS before and after anesthesia induction (r = 0.85, p = 0.029). By comparing the absolute values of standardized regression coefficients (0.58, 0.21, 0.19, and 0.12) of the four variables, it can be seen that TL contributes the most to the propofol dose in anesthesia induction. However, the mutation at the 5’ end or 3’ end of TERC was not found. Conclusions: These findings provide preliminary evidence that the propofol dose in anesthesia induction was clearly correlated with genetically determined TL. TL may be a promising predictor of the propofol dose, which is beneficial to improve the safety of anesthesia and reduce perioperative complications. Introduction aging (TL trait disease (TERC operation elderly Methods leukocytes (BIS analyses 5end 5 3end 3 detected 10 surgery Results r 078 0 78 0.78 0.001, 0001 0.001 , 001 0.001) 084 84 0.84 0.004, 0004 0.004 004 0.004) 083 83 0.83 085 85 0.85 0.029. 0029 0.029 . 029 0.029) 0.58, 058 58 (0.58 021 21 0.21 019 19 0.19 0.12 012 12 variables However Conclusions complications 1 07 7 0.7 000 0.00 00 08 8 0.8 002 0.02 02 0.58 05 (0.5 2 0.2 01 0.1 0. 0.0 0.5 (0. (0 (

ABSTRACT Purpose: To determine the predictive value of maternal White Blood Cells (WBC), neutrophils, and C-Reactive Protein (CRP) for diagnosing Histological Chorioamnionitis (HCA) among women with Preterm Premature Rupture of Membranes (PPROM) who underwent cervical cerclage. Methods: A retrospective cross-sectional study was conducted among women with singleton pregnancy and PPROM, who underwent cervical cerclage during 2018-2020. Results: A total of 55 eligible women were included in the final analysis, including 36 (61.02%) cases with HCA and 19 (38.98%) without HCA. Women with HCA had higher WBC count (12.31 ± 2.80) × 109/L and neutrophil count (9.67 ± 2.90)×109/L than those without HCA (10.35 ± 2.53) × 109/L and 7.82 ± 2.82 × 109/L, respectively) (both p < 0.05). The cut-off value of WBC count at 10.15×109/L was found to be the most effective in identifying HCA, with an Area Under Curve (AUC) of 0.707 (95% CI: 0.56-0.86; p = 0.012), sensitivity of 86.11%, specificity of 57.90%, Positive Predictive Value (PPV) of 79.49%, Negative Predictive Value (NPV) of 68.75%, and Youden index of 0.44. The combination of WBC + neutrophil had a slightly higher (AUC = 0.711, 95% CI: 0.57–0.86; p = 0.011), specificity (68.42%), and PPV (81.25%), but lower sensitivity (72.22%), than the WBC count alone. A cut-off value of neutrophil at 7.46 × 109/L was effective in identifying HCA, with an AUC of 0.689 (95% CI: 0.53-0.84; p = 0.022). Discussion: Combination use of WBC+neutrophil was found to be the most accurate predictor of HCA among women with PPROM after surgery of cervical cerclage. Purpose WBC, , (WBC) neutrophils CReactive C Reactive CRP (CRP (HCA (PPROM Methods crosssectional cross sectional 20182020. 20182020 2018 2020. 2020 2018-2020 Results 5 analysis 3 61.02% 6102 61 02 (61.02% 1 38.98% 3898 38 98 (38.98% 12.31 1231 12 31 (12.3 2.80 280 2 80 109L L 109 9.67 967 9 67 (9.6 2.90×109/L 290109L 2.90 ×109/L 90 10.35 1035 10 35 (10.3 2.53 253 53 782 7 82 7.8 282 2.8 respectively both 0.05. 005 0.05 . 0 05 0.05) cutoff cut off 1015109L 15 0707 707 0.70 95 (95 CI 0.560.86 056086 0.56 0.86 56 86 0.56-0.86 0.012, 0012 0.012 012 0.012) 8611 11 86.11% 5790 57 57.90% (PPV 7949 79 49 79.49% NPV (NPV 6875 68 75 68.75% 044 44 0.44 0711 711 0.711 0.57–0.86 057086 0.011, 0011 0.011 011 0.011) 68.42%, 6842 68.42% 42 (68.42%) 81.25%, 8125 81.25% 81 25 (81.25%) 72.22%, 7222 72.22% 72 22 (72.22%) alone 746 46 7.4 0689 689 0.68 0.530.84 053084 0.53 0.84 84 0.53-0.84 0.022. 0022 0.022 022 0.022) Discussion WBCneutrophil (WBC 2018202 201 202 2018-202 61.02 610 6 (61.02 38.98 389 (38.98 12.3 123 (12. 28 8 9.6 96 (9. 290 2.9 10.3 103 (10. 2.5 78 7. 2. 00 0.0 070 70 0.7 (9 560 0.560.8 05608 056 0.5 086 0.8 0.56-0.8 001 0.01 01 861 86.11 579 57.90 794 4 79.49 687 68.75 04 0.4 071 71 0.71 0.57–0.8 05708 684 68.42 (68.42% 812 81.25 (81.25% 722 72.22 (72.22% 74 068 0.6 530 0.530.8 05308 053 084 0.53-0.8 002 0.02 201820 20 2018-20 61.0 (61.0 38.9 (38.9 12. (12 9. 29 10. (10 0. 07 ( 0.560. 0560 08 0.56-0. 86.1 57.9 79.4 68.7 0.57–0. 0570 68.4 (68.42 81.2 (81.25 72.2 (72.22 06 0.530. 0530 0.53-0. 20182 2018-2 61. (61. 38. (38. (1 0.560 0.56-0 86. 57. 79. 68. 0.57–0 057 (68.4 81. (81.2 72. (72.2 0.530 0.53-0 2018- (61 (38 0.56- 0.57– (68. (81. (72. 0.53- (6 (3 0.57 (68 (81 (72 (8 (7

RESUMEN Introducción: El entrenamiento debe realizarse de acuerdo con las características del baloncesto estableciendo un sistema de índices de evaluación científica para explotar plenamente el potencial de sus jugadores. Objetivo: Evaluar el sistema de índices de medición del entrenamiento físico específico para jugadores de baloncesto. Métodos: Se estudiaron los índices de evaluación del entrenamiento físico de los deportistas mediante la comprobación de la literatura científica y la estadística matemática, y se diseñó y experimentó un índice de evaluación del entrenamiento físico de los jóvenes jugadores de baloncesto. Resultados: La proporción más alta de la puntuación de la aptitud física especial en la media atlética fue del 46,25%; la proporción de la puntuación de la aptitud física general de los jugadores representó un 15% por encima y un 13,75% por debajo, el nivel de aptitud física específica de los jugadores de baloncesto está principalmente en el nivel medio. Conclusión: Los efectos del entrenamiento pueden evaluarse eficazmente mediante el sistema de índice de experiencia, y es útil para que los deportistas encuentren las deficiencias, aprovechen al máximo su propio potencial, mejoren las habilidades y adapten las tácticas de baloncesto. También puede proporcionar más talentos de reserva para el baloncesto profesional. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento. Introducción Objetivo Métodos matemática Resultados 46,25% 4625 46 25 15 1375 13 75 13,75 debajo medio Conclusión experiencia deficiencias profesional II tratamiento 46,25 462 4 2 1 137 7 13,7 46,2 13, 46,

RESUMO Introdução: O treinamento deve ser realizado de acordo com as características do basquetebol estabelecendo um sistema de índice de avaliação científica para explorar plenamente o potencial de seus jogadores. Objetivo: Avaliar o sistema de índices de medição do treinamento físico específico para os jogadores de basquetebol. Métodos: Os índices de avaliação do treinamento físico dos atletas foram estudados verificando a literatura científica e estatísticas matemáticas, um índice de avaliação para o treinamento físico de jovens jogadores de basquetebol foi projetado e experimentado. Resultados: A maior proporção da pontuação da aptidão física especial na média atlética foi de 46,25%; a proporção da pontuação da aptidão física geral dos jogadores representou 15% acima e 13,75% abaixo, o nível de aptidão física específica dos jogadores de basquetebol está principalmente no nível mediano. Conclusão: Os efeitos do treinamento podem ser efetivamente avaliados pelo sistema de índice experimentado, sendo útil para que os atletas possam encontrar deficiências, aproveitar plenamente seu próprio potencial, melhorar as habilidades e adaptar as táticas do basquetebol. Também poderá fornecer mais talentos de reserva para o basquetebol profissional. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento. Introdução Objetivo Métodos matemáticas experimentado Resultados 46,25% 4625 46 25 15 1375 13 75 13,75 abaixo mediano Conclusão deficiências profissional II tratamento 46,25 462 4 2 1 137 7 13,7 46,2 13, 46,

ABSTRACT Introduction: The training should be performed according to the characteristics of basketball by establishing a scientific evaluation index system to fully exploit the potential of its players. Objective: Evaluate the index system for measuring physical training specific to basketball players. Methods: The physical training evaluation indexes of athletes were studied by checking the scientific literature and mathematical statistics, and an evaluation index for the physical training of young basketball players was designed and experimented. Results: The highest proportion of the special fitness score in athletic average was 46.25%; the proportion of the players’ general fitness score represented 15% above and 13.75% below. The specific fitness level of basketball players is mainly at the average level. Conclusion: The effects of training can be effectively evaluated by the experienced index system, and it is useful for athletes to find deficiencies, make full use of their potential, improve skills and adapt basketball tactics. It may also provide more reserve talent for professional basketball. Level of evidence II; Therapeutic studies - investigation of treatment outcomes. Introduction Objective Methods statistics experimented Results 46.25% 4625 46 25 15 1375 13 75 13.75 below Conclusion deficiencies tactics II outcomes 46.25 462 4 2 1 137 7 13.7 46.2 13. 46.

RESUMO Introdução O treinamento progressivo da força pode ajudar os atletas a melhorar seus níveis de força de maneira rápida e segura. Controlando a frequência e a amplitude das vibrações, os músculos podem produzir contrações inconscientes e voluntárias que ajudam a prevenir doenças como a osteoporose. Objetivo Explorar a alteração no desempenho esportivo ocasionado pelo treinamento progressivo da força muscular nos membros superiores dos jogadores de tênis de mesa. Métodos 12 jogadores de tênis de mesa com experiência mínima de 5 anos foram aleatoriamente divididos em grupos experimental e controle. O controle efetuou métodos tradicionais de treinamento de força enquanto o grupo experimental utilizou o método progressivo de treinamento de força dirigida, desenvolvido pela equipe de pesquisa, por nove semanas. Os testes foram realizados no equipamento ISOMED 2000 nas condições de 60°/s e 450°/s. Resultados A circunferência, força muscular e a relativa força dos membros superiores aumentaram. Houve diferença na taxa do momento de flexão máxima do cotovelo dos atletas do grupo experimental nas condições de teste de 60°/s. A 450°/s, o momento máximo de flexão do cotovelo e o momento máximo de extensão do cotovelo também mostraram uma diferença significativa (P<0,05). Conclusão O método de treinamento progressivo de força afeta significativamente o momento máximo de flexão do cotovelo e o momento máximo de extensão do cotovelo dos atletas do que os métodos tradicionais de treinamento de força. O progresso da força muscular foi notado principalmente nas articulações do cotovelo e pulso, com menor intensidade nos ombros. Nível de evidência II; Estudos Terapêuticos - Investigação de Resultados.

ABSTRACT Introduction Progressive strength training can help athletes improve their strength levels quickly and safely. By controlling the frequency and amplitude of vibrations, muscles can produce unconscious and voluntary contractions that help prevent diseases such as osteoporosis. Objective To explore the change in sports performance caused by progressive upper limb muscle strength training in table tennis players. Methods 12 table tennis players with a minimum experience of 5 years were randomly divided into experimental and control groups. The control performed traditional strength training methods while the experimental group used the progressive directed strength training method developed by the research team for nine weeks. Tests were performed on ISOMED 2000 equipment at the conditions of 60°/s and 450°/s. Results Circumference, muscle strength, and relative upper limb strength increased. In addition, a difference in the rate of the maximum elbow flexion moment of the athletes in the experimental group in the 60°/s test conditions was observed. At 450°/s, the maximum flexion and extension elbow moment showed a significant difference (P<0.05). Conclusion The progressive strength training method significantly affects the athletes’ maximum elbow flexion moment and maximum elbow extension moment than traditional strength training methods. Muscle strength progress was noted mainly in the elbow and wrist joints, with less intensity in the shoulders. Evidence Level II; Therapeutic Studies – Investigating the results.

RESUMEN Introducción El entrenamiento de fuerza progresivo puede ayudar a los atletas a mejorar sus niveles de fuerza de forma rápida y segura. Al controlar la frecuencia y la amplitud de las vibraciones, los músculos pueden producir contracciones inconscientes y voluntarias que ayudan a prevenir enfermedades como la osteoporosis. Objetivo Explorar el cambio en el rendimiento deportivo provocado por el entrenamiento progresivo de la fuerza muscular en las extremidades superiores de los jugadores de tenis de mesa. Métodos 12 jugadores de tenis de mesa con una experiencia mínima de 5 años fueron divididos aleatoriamente en grupos experimental y de control. El grupo de control realizó métodos de entrenamiento de fuerza tradicionales, mientras que el grupo experimental utilizó el método de entrenamiento de fuerza dirigido progresivo desarrollado por el equipo de investigación durante nueve semanas. Las pruebas se realizaron en el equipo ISOMED 2000 en las condiciones de 60°/s y 450°/s. Resultados La circunferencia, la fuerza muscular y la fuerza relativa de los miembros superiores aumentaron. Hubo una diferencia en la velocidad del momento de flexión máxima del codo de los atletas del grupo experimental en las condiciones de prueba de 60°/s. A 450°/s, el momento máximo de flexión del codo y el momento máximo de extensión del codo también mostraron una diferencia significativa (P<0,05). Conclusión El método de entrenamiento de fuerza progresivo afecta significativamente al momento de flexión máxima del codo de los atletas y al momento de extensión máxima del codo que los métodos tradicionales de entrenamiento de fuerza. El progreso de la fuerza muscular se observó principalmente en las articulaciones del codo y la muñeca, con menor intensidad en los hombros. Nivel de evidencia II; Estudios terapéuticos - Investigación de resultados.

Abstract Introduction: the frail status of elderly hypertensive patients easily damages the function of many physiological systems. Objectives: we aimed to investigate the correlation between the frail status and lower extremity function of elderly hospitalized patients with hypertension. Methods: a total of 336 eligible subjects were assigned to frail, pre-frail and non-frail groups according to the “Frail” scale. Lower extremity function was assessed by the Short Physical Performance Battery including chair-sit-to-stand, three-posture balance and 6-meter gait speed tests. The influences of factors on frailty were evaluated using the Cox multivariate regression analysis. The correlation between frailty score and lower extremity function score was explored by Spearman's analysis. The values of factors for predicting frail status were analyzed by plotting receiver operating characteristic (ROC) curves. Results: the three groups had similar age, systolic blood pressure, and nutritional, sleepiness and lower extremity function statuses (p < 0.05). Compared with the non-frail group, the lower extremity function score of the frail group was lower (p < 0.05). Age, systolic blood pressure and sleepiness status were the independent risk factors of frailty (p < 0.05), and lower extremity function parameters were independent protective factors (p < 0.05). There were negative correlations between frail status and lower extremity function parameters (p < 0.05). The area under the ROC curve was 0.850, and the optimal cutoff value was 7.80. Lower extremity function had a high value for predicting frail status. Conclusions: lower extremity function is negatively correlated with the frail status of elderly hospitalized patients with hypertension, as a protective factor of frailty, which can be used to predict frail status.

Resumen Introducción: el estado frágil de los pacientes hipertensos de edad avanzada daña fácilmente la función de muchos sistemas fisiológicos. Objetivos: nuestro objetivo fue investigar la correlación entre el estado frágil y la función muscular de pacientes ancianos hospitalizados con hipertensión. Métodos: un total de 336 sujetos elegibles fueron asignados a grupos de frágiles, pre-frágiles y no frágiles de acuerdo con la escala de fragilidad. La función muscular se evaluó mediante la batería de rendimiento físico corto, que incluye las pruebas de sentarse y levantarse de una silla, equilibrio de tres posturas y velocidad de marcha de 6 metros. Las influencias de los factores sobre la fragilidad se evaluaron mediante el análisis de regresión multivariante de Cox. La correlación entre el puntaje de fragilidad y el puntaje de función muscular se exploró con el análisis de Spearman. Los valores de los factores para predecir el estado frágil se analizaron mediante el trazado de curvas características de funcionamiento del receptor (ROC). Resultados: los tres grupos tenían edades similares y valores similares de presión arterial sistólica y estado nutricional, somnolencia y función muscular (p < 0,05). En comparación con el grupo no frágil, la puntuación de la función muscular del grupo frágil fue menor (p < 0,05). La edad, la presión arterial sistólica y el estado de somnolencia fueron los factores de riesgo independientes de fragilidad (p < 0,05), y los parámetros de función muscular fueron factores protectores independientes (p < 0,05). Hubo correlaciones negativas entre el estado frágil y los parámetros de la función muscular (p < 0,05). El área bajo la curva ROC fue de 0,850 y el valor de corte óptimo fue de 7,80. La función muscular tuvo un valor alto para predecir el estado frágil. Conclusiones: la función muscular se correlaciona negativamente con el estado frágil de los pacientes ancianos hospitalizados con hipertensión, como factor protector de la fragilidad, que se puede utilizar para predecir el estado frágil.

RESUMO Introdução: O treino excessivo no futebol é causado por um desequilíbrio entre a carga corporal, o estresse e a recuperação. O treinamento físico não científico de alto volume e as partidas contínuas de futebol de alta intensidade costumam ser as principais razões do treinamento excessivo dos atletas. Objetivo: Este artigo explora as características das mudanças de função física dos jogadores de futebol durante um ciclo completo de treinamento. Métodos: Usamos métodos experimentais para analisar as mudanças nas características de carga física de jogadores de futebol durante o treinamento de alta intensidade. Resultados: Os indicadores de creatina quinase, nitrogênio da ureia sanguínea e transporte de oxigênio não significativamente durante o treinamento de futebol. A testosterona e o cortisol aumentam gradualmente com o aumento da carga dos exercícios. Conclusões: No treinamento de futebol, precisamos organizar razoavelmente o volume total do exercício, sua intensidade e o tempo de intervalo dos atletas, de acordo com a adaptabilidade física e habilidade atlética do treinador, e com medidas de recuperação nutricional e de entusiasmo. Esses métodos podem melhorar ou aprimorar a função física dos jogadores de futebol. Nível de Evidência II; Estudos terapêuticos - Investigação dos resultados do tratamento.

ABSTRACT Introduction: Overtraining in football is caused by an imbalance between body load, stress, and recovery. High-volume non-scientific physical training and continuous high-intensity football matches are often the main reasons for the overtraining of athletes. Objective: This article explores the characteristics of the changes in physical function of football players during a complete training cycle. Methods: We use experimental methods to analyze the changes in the physical load characteristics of football players during high-intensity training. Results: Creatine kinase, urea nitrogen, and oxygen transport indicators did not change significantly during football training. Testosterone and cortisol will gradually increase with an increase of exercise load. Conclusion: In football training, we need to reasonably arrange the total exercise volume, exercise intensity, and exercise interval time of the athletes according to the trainer’s physical adaptability and athletic ability, supplemented with nutrition and enthusiasm recovery measures. These methods can improve or enhance the physical function of football players. Level of evidence II; Therapeutic studies - investigation of treatment results.

RESUMEN Introducción: El sobreentrenamiento en el fútbol es causado por un desequilibrio entre la carga corporal, el estrés y la recuperación. El entrenamiento físico de alto volumen no científico y los partidos de fútbol continuos de alta intensidad suelen ser las principales razones del sobreentrenamiento de los atletas. Objetivo: Este artículo explora las características de los cambios en la función física de los jugadores de fútbol durante un ciclo completo de entrenamiento. Métodos: Utilizamos métodos experimentales para analizar los cambios en las características de la carga física de los jugadores de fútbol durante el entrenamiento de alta intensidad. Resultados: Los indicadores de creatina quinasa, nitrógeno ureico en la sangre y transporte de oxígeno no fueron significativos durante el entrenamiento. La testosterona y el cortisol aumentan gradualmente con el aumento de la carga de ejercicios. Conclusiones: En el entrenamiento de fútbol, se debe organizar razonablemente el volumen total de ejercicios, la intensidad y el tiempo de intervalo de los atletas en función del acondicionamiento físico y la capacidad atlética del entrenador, y con medidas de recuperación nutricional y de entusiasmo. Estos métodos pueden mejorar o potenciar la función física de los jugadores de fútbol. Nivel de Evidencia II; Estudios terapéuticos - Investigación de los resultados del tratamiento.

Abstract To evaluate the expression of miR-155 and autophagy in COPD and the related mechanism. Alveolar macrophages were extracted from COPD patients. COPD dynamic mouse model was established. Mouse alveolar macrophages were also isolated and cultured. Rat alveolar macrophage cell line NR8383 was introduced. The expression of TLR4 and NF-κB in NR8383 cells with CSE treatment was also evaluated. miR-155 was upregulated in alveolar macrophages from bronchoalveolar lavage fluid of COPD patients, COPD dynamic mouse model and CSE treated NR8383 cell line (p < 0.05). Overexpression of miR‐155 led to dysregulation of cell autophagy and was closely. miR‐155 promoted cell autophagy by directly targeting TLR4/NF-κB pathway in NR8383 cell line. Our study revealed a novel inflammatory role of miR-155 in COPD and the related mechanisms. We provide a new perspective to understand the pathogenesis of COPD, and miR-155 might be useful as potential target for the treatment of COPD.

Abstract: A renewable tannin-based resin adhesive with enhanced bonding strength, good water resistance and long storage life has been prepared based on tannin, furfural and furfuryl alcohol coming from forest and agricultural products. Fourier transform infrared spectroscopy (FT-IR), Electrospray ionization mass spectroscopy (ESI-MS) and Differential scanning calorimetry (DSC) indicated that furfuryl alcohol and furfural can react with tannin under acidic conditions, with the involvement of -CH2-O- groups in the cross-linking of tannin-furfuryl alcohol-furfural resin (TFF) adhesive. The gel time of TFF was longer than that of tannin-furfural resin (TF), while the shear strength of TFF-bonded plywood suggested that the cured TFF adhesive acquired a performance superior to that of tannin (T) and TF adhesives. Furthermore, water resistance of TFF adhesive could be further enhanced with respect to T and TF adhesives through cross-linking with 3 % epoxy resin (EPR).

Abstract: In this study, an easily prepared bio-based abrasive grinding wheel based on tannin-glyoxal-urea (TGU)thermosetting matrix is presented.The synthesised resin was prepared via co-polycondensation reaction of glyoxal and ureawith condensed tannin, which is a forest-derived product. Fourier transform infrared spectroscopy and electrospray ionisation mass spectrometry results confirmed that urea and glyoxal react well under acidic conditions and that -(OH)CH-NH-group is primarily involved in TGU cross-linking. Differential scanning calorimetry, thermomechanical analysis and thermogravimetric analysis investigations showed that the preparation of TGU resin is easier compared to commercial phenol-formaldehyde (PF) resin; moreover, TGU resin has a more robust chemical network structure, which contributes efficiently to heat resistance and improved mechanical properties. This observation is supported by Brinell hardness, compression resistance and grinding testing; these showed that the new grinding wheel acquired higher hardness, superior resistance against compression and stronger abrasion resistance compared with a PF-based grinding wheel prepared in the laboratory. Moreover, few holes and no cracks were found in the new grinding wheel.

ABSTRACT Background: Previous studies showed consistent results for associations between circulating concentrations of vitamin D and risk of antenatal, postnatal depression. Methods: Articles published in English before November 2020 were searched in databases as follows: PubMed, EMBASE, Web of Science, Medline, Google Scholar and Cochrane. These articles explored associations between circulating concentrations of vitamin D and risk of antenatal, postnatal depression.The present meta-analysis was conducted using STATA 12.0 software. Odds ratios (ORs) and 95% confidence intervals (CIs) extracted from included studies were computed using a random effects model or a fixed effects model according to heterogeneities between included studies. Q test and I2 were used to explore heterogeneities between included studies. Results: 7 cohort studies (including 1567 depression cases and 5254 controls) and 3 case-control studies (including 995 depression cases and 1265 controls) were included in the present study. The study showed that low circulating levels of 25-hydroxy (OH) vitamin D is significantly associated with a higher risk of antenatal and postnatal depression (OR = 1.02, 95% CI 1.01 to 1.04, I2 = 90.7%, p < 0.001). Conclusion: Our results have shown that the low level of vitamin D may be an adverse factor of antenatal and postnatal depression.

Abstract INTRODUCTION: Leptin (LEP) is a peptide hormone that acts via leptin receptor (LEPR) binding. Genetic evidence from different human populations has implicated LEP/LEPR in the pathogenesis of coronary artery disease (CAD), and suggests that certain LEP/LEPR gene polymorphisms may increase the risk of CAD. The aim of this study was to assess two single nucleotide polymorphisms (SNPs) in LEP genes (rs2167270 and rs7799039) and two in LEPR genes (rs6588147, rs1137100) for association with CAD. METHODS: We enrolled 271 North Chinese Han CAD patients, and 113 healthy age- and sex-matched controls. Genomic DNA was extracted from whole blood, and the four SNPs were assessed using a MassArray system. RESULTS: The G allele frequency at rs2167270 was significantly higher among CAD cases than among controls. The AG genotype at rs7799039 was associated with a significantly decreased risk of CAD unlike the AA genotype used as the reference. The A allele was significantly associated with the CAD patient group. Interestingly, statistically significant differences in genotype and allele frequency at LEP rs2167270 and rs7799039 existed among females but not among males. CONCLUSIONS: The current study detected a significant association between genetic variations at LEP rs7799039 and rs2167270 and the risk of CAD in a north Chinese population, and revealed that LEP rs2167270 and rs7799039 gene polymorphisms might act as predisposing factors for CAD.

RESUMO A escassez de água levou à adoção de tecnologia de irrigação que economiza água em todo o mundo. A irrigação por gotejamento tem sido usada para o cultivo de arroz em Xinjiang, China. Pesquisadores relataram 12,0 t/ha de rendimento; no entanto, o arroz irrigado por gotejamento produz cerca de 6-8 t/ha na prática, e está claro que a deficiência de água explica essa lacuna. Portanto, o objetivo deste experimento foi comparar o crescimento, as características fotossintéticas e a atividade antioxidante do arroz cultivado em solução nutritiva com potencial hídrico de 0,00, -0,02, -0,05 e -0,09 MPa [0, 2,5, 5,0 e 7,5 % polietilenoglicol (PEG), respectivamente], para determinar as condições ótimas da água para o arroz irrigado por gotejamento. Não houve diferença significativa entre os tratamentos 0, 2,5 e 5,0% de PEG para a taxa de crescimento relativo e o conteúdo relativo de água após 10 e 20 dias. No entanto, os tratamentos de 2,5 e 5,0% de PEG afetaram substancialmente a capacidade fotossintética e a atividade das enzimas antioxidantes após 10 e 20 dias. O tratamento com 7,5% de PEG inibiu o crescimento das brotações. Houve uma redução significativa na atividade das enzimas antioxidantes. O cultivo de arroz que economiza água, como o arroz irrigado por gotejamento, sofreu um leve estresse hídrico de -0,02 a -0,05 Mpa, mas isso não inibiu o crescimento. A quantidade de irrigação deve ser aumentada para obter maiores rendimentos de arroz sob condições de irrigação por gotejamento.

ABSTRACT Water scarcity has led to the adoption of water-saving irrigation technology around the world. Drip-irrigation has been used for rice (Oryza sativa L.) cultivation in Xinjiang, China. Researchers reported 12.0 t/ha yield; however, drip-irrigated rice produces around 6-8 t/ha in practice, and it is clear that water deficiency explains this gap. Therefore, the objective of this experiment was to compare the growth, photosynthetic characteristics, and antioxidant activity of rice grown in nutrient solutions with water potentials of 0.00, -0.02, -0.05, and -0.09 MPa [0, 2.5, 5.0, and 7.5% polyethylene glycol (PEG), respectively], to determine the optimal water conditions for drip-irrigated rice. There was no significant difference between the 0, 2.5, and 5.0% PEG treatments for relative growth rate and relative water content after 10 and 20 days. However, 2.5 and 5.0% PEG treatments substantially affected the photosynthetic capacity and antioxidant enzyme activity after 10 and 20 days. Treatment with 7.5% PEG inhibited shoot growth. There was a significant reduction in antioxidant enzyme activity. Water-saving rice cultivation, such as drip-irrigated rice, suffered mild drought stress at -0.02 to -0.05 Mpa, but this did not inhibit growth. The amount of irrigation should be increased to obtain higher rice yields under drip-irrigation conditions.