RESUMEN Estudiar la estabilidad del soporte de un frente de explotación carbonífero bajo las condiciones de un ángulo de inmersión grande (LDA) y una explotación minera alta (LMH) es esencial para garantizar la seguridad y la alta eficiencia minera. Este estudio se basa en el frente de trabajo número #3up509 de la Mina de Carbón Gaozhuang (GCM) afiliada al área minera de Zaozhuang. Los autores analizaron las características mecánicas de apoyo en un frente de trabajo que cumple con las condiciones LDA y LMH. Con esta base se desarrollaron los modelos mecánicos que permitan al apoyo deslizarse e inclinarse en el área del frente de trabajo. Luego, se analizó la estabilidad del apoyo en el rumbo del frente de trabajo durante un periodo normal de explotación (NMP) y en un período especial de explotación (SMP). Los resultados muestran que la resistencia crítica de la inclinación del apoyo durante el período NMP es de 52.2 kN, y la resistencia crítica del deslizamiento es de 183.75 kN. Y para el período SMP, los valores son 229,7 kN y 4425 kN. Además, se investigó el uso de un apoyo de escudo con dos pies, conocido como ZY6600-25.5/55 (su capacidad de resistencia está calculada en 6600 kN), que funciona bien en los frentes de trabajo. Finalmente se tomaron algunas medidas técnicas como instalar un enclavamiento para amarrar un apoyo y un gato de elevación, lo que incrementa la capacidad de carga del apoyo y optimiza el método de desplazamiento del apoyo, para mejorar la estabilidad general del apoyo en el frente de trabajo carbonífero. El objetivo inicial de seguridad y alta eficiencia minera para el frente de trabajo carbonífero #3 509 se alcanzó con estas medidas.

ABSTRACT Studying the support stability of a coalface with a large dip angle (LDA) and large mining height (LMH) under the corresponding conditions is essential to ensure safe and high-efficiency mining. This study is based on the #3up509 coalface of the Gaozhuang Coal Mine (GCM) affiliated with the Zaozhuang Mining Area. The authors analyzed the mechanical characteristics of support in the coalface with LDA and LMH. On this basis, the mechanical models for support tilting and sliding in the coalface were developed. Then, support stability along the coalface’s strike during the normal mining period (NMP) and special mining period (SMP) was analyzed. The results show that the critical support tilting resistance during the NMP is 52.2 kN, and the critical support sliding resistance is 183.75 kN. And for the SMP, the values are 229.7 kN and 4425 kN. The use of two-leg shield support, known as ZY6600-25.5/55 (its rated working resistance is 6600 kN), is investigated, which is proved reasonable for the coalface. Finally, some technical measures, such as installing an interlock set to fasten support and adjustable lifting jack, increasing the setting load of the support, and optimizing the support displacement method, are taken to improve the coalface’s overall support stability. The initial aim for safe and high-efficiency mining of the #3up509 coalface has been achieved through these measures.

Abstract Lung cancer has one of the highest mortality rates of malignant neoplasms. Lung adenocarcinoma (LUAD) is one of the most common types of lung cancer. DNA methylation is more stable than gene expression and could be used as a biomarker for early tumor diagnosis. This study is aimed to screen potential DNA methylation signatures to facilitate the diagnosis and prognosis of LUAD and integrate gene expression and DNA methylation data of LUAD to identify functional epigenetic modules. We systematically integrated gene expression and DNA methylation data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), bioinformatic models and algorithms were implemented to identify signatures and functional modules for LUAD. Three promising diagnostic and five potential prognostic signatures for LUAD were screened by rigorous filtration, and our tumor-normal classifier and prognostic model were validated in two separate data sets. Additionally, we identified functional epigenetic modules in the TCGA LUAD dataset and GEO independent validation data set. Interestingly, the MUC1 module was identified in both datasets. The potential biomarkers for the diagnosis and prognosis of LUAD are expected to be further verified in clinical practice to aid in the diagnosis and treatment of LUAD.

Resumo A melhoria do valor da informação artística e dos fatores de comportamento do usuário pode aprimorar o efeito da comunicação e do desenvolvimento da arte. Portanto, este artigo propõe um modelo de comunicação e desenvolvimento da arte s-seir baseado na rede social. Combinado com o conceito e com as características da comunicação artística, com base no modelo clássico de dinâmica epidêmica SEIR (Suscetíveis, Expostos, Infecciosos e Recuperados) considerando-se o valor da informação artística e fatores de comportamento dos usuários, é proposto o modo de comunicação e de desenvolvimento da arte s-seir baseado na rede social. As regras de evolução da classificação dos nódulos e da informação da arte são resumidas, e o modelo de comunicação e de desenvolvimento da arte s-seir baseado na rede social é projetado. Os resultados experimentais mostram que o modelo pode analisar claramente o impacto do valor da arte e o comportamento do usuário na divulgação e desenvolvimento da informação da arte e tem como vantagens alta eficiência e precisão.

Abstract Improving the value of art information and user behavior factors can boost the effect of art communication and development. This paper proposes a social network based on the s-seir (Single SEIR) art communication and development model, a new model developed based on the SEIR (Susceptible, Exposed, Infectious, Recovered) classical epidemic dynamics model. In addition, we present the concept and characteristics of art communication, summarize the rules of node classification and art information evolution, and design an interpretative s-seir model considering the value of art information and user behavior factors. The experimental results show that the model can clearly analyze the impact of art value and user behavior on the dissemination and development of art information, and has the advantages of high efficiency and accuracy.