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Experimental and numerical simulation analysis of the dynamic characteristics of a new piezoelectric friction damper
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Dai, Jianbo

; Zhao, Zewen

; Wang, Hao

; Ma, Jing

; Liang, Xuhao

Latin American Journal of Solids and Structures

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2024, Volume 21 N. 1 elocation e517

Abstract: En | Text: En | PDF: En

Abstract Based on the inverse piezoelectric effect and other characteristics of piezoelectric ceramics, a new type of piezoelectric variable friction damper is developed, and the output performance test of piezoelectric ceramic actuator and piezoelectric variable friction damper is carried out, and the parametric mechanical model of the damper is established by using Simulink to carry out numerical simulation, and compared and analyzed with the test results. The results of the study show that the simulation and the test present a good regular agreement. With the increment of loading voltage, the displacement deformation and zero-displacement thrust of piezoelectric ceramic actuator are approximately linear with the loading voltage; when the loading voltage is increased by 15V every time, the test value of the output damping force of the damper increases by 259.66N on average step by step, and the simulated value increases by 256.14N step by step, and the damping force has a linearly incremental relationship with the voltage and the slope of the linear increase is 16.434. ceramics developed agreement zerodisplacement zero V time 25966N N 259 66N 25614N 256 14N 16434 16 434 16.434 25 1643 1 43 16.43 2 164 4 16.4 16.

https://doi.org/10.1590/1679-78257902

Moral thought: evaluation on the moral education and virtue cultivation of traditional Chinese music thought
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Wang, Hao

Trans/Form/Ação

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2024, Volume 47 N. 5 elocation e02400167

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract: As one of the treasures of Chinese culture, Chinese traditional music has been carrying rich moral thoughts since ancient times, and it is an important part of the value system of Chinese traditional culture. However, with the society’s development and the diversification of culture, the rapid social rhythm and the popularity of popular music have brought great impact on traditional music, and it has been gradually forgotten due to its neglect. By exploring the application and value of traditional Chinese music in moral education and virtue cultivation, this paper combined traditional music culture with the modern residents’ living habits, such as education, large-scale social events, competitions and music festivals. Through school education and regular community activities, this paper can provide new ideas and practical experience for the inheritance and innovation of traditional culture. Through the integration of modern media and art forms, the moral concept of traditional music is connected with modern society, forming a new cultural ecology that is more modern and inclusive. By making use of the rich moral thought resources in traditional Chinese music, it shows that traditional Chinese music has irreplaceable role and value in moral education and virtue cultivation. Abstract times However societys society s neglect cultivation residents habits largescale large scale events festivals activities forms inclusive

Resumo: Sendo um dos tesouros da cultura chinesa, a música tradicional chinesa tem carregado ricos pensamentos morais desde os tempos antigos. sendo uma parte importante do sistema de valores da cultura tradicional chinesa. No entanto, com o desenvolvimento da sociedade e a diversificação da cultura, o rápido ritmo social e a popularidade da música popular trouxeram grande impacto à música tradicional, que foi gradualmente esquecida devido ao seu abandono. Ao explorar a aplicação e o valor da música tradicional chinesa na educação moral e no cultivo da virtude neste artigo, combinamos a cultura musical tradicional com os hábitos de vida dos residentes modernos, tais como educação, eventos sociais de grande escala, competições e festivais de música. Através da educação escolar e de atividades comunitárias regulares, buscamos fornecer novas ideias e experiências práticas para a herança e inovação da cultura tradicional. Através da integração dos meios de comunicação modernos e das formas de arte, o conceito moral da música tradicional está ligado à sociedade moderna, formando uma nova ecologia cultural mais moderna e inclusiva. Ao fazer uso dos ricos recursos de pensamento moral da música tradicional chinesa, mostramos que o seu papel e valor insubstituíveis na educação moral e no cultivo da virtude. Resumo antigos entanto abandono artigo escala regulares arte inclusiva

https://doi.org/10.1590/0101-3173.2024.v47.n5.e02400167

Prediction of health disorders in dairy cows monitored with collar based on Binary logistic analysis
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Zhou, Xiaojing

; Xu, Chuang

; Zhao, Zixuan

; Wang, Hao

; Chen, Mengxing

; Jia, Bin

Arquivo Brasileiro de Medicina Veterinária e Zootecnia

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jun 2023, Volume 75 N. 3 Pages 467 - 475

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT The objective of this study was to analyze data on physical activity and rumination time monitored via collars at the farm coupled with milk yield recorded by the rotary milking system to predict cows based on several disorders using the binary Logistic regression conducted with R software. Data for metritis (n=60), mastitis (n=98), lameness (n=35), and digestive disorders (n=52) were collected from 1,618 healthy cows used to construct the prediction model. To verify the feasibility and adaptability of the proposed method, we analyzed data of cows in the same herd (herd 1) not used to construct the model, and cows in another herd (herd 2) with data recorded by the same type of automated system, and led to detection of 75.0%, 64.2%, 74.2%, and 76.9% animals in herd 1 correctly predicted to suffer from metritis, mastitis, lameness, and digestive disorders, respectively. For cows in herd 2, 66.6%, 58.8%, 80.7%, and 71.4% were correctly predicted for metritis, mastitis, lameness, and digestive disorders, respectively. Compared with traditional clinical diagnoses by farm personnel, the algorithm developed allowed for earlier prediction of cows with a disorder. software n=60, n60 n n=60 , 60 (n=60) n=98, n98 n=98 98 (n=98) n=35, n35 n=35 35 (n=35) n=52 n52 52 (n=52 1618 618 1,61 model method 2 750 75 0 75.0% 642 64 64.2% 742 74 74.2% 769 76 9 76.9 respectively 666 66 6 66.6% 588 58 8 58.8% 807 80 7 80.7% 714 71 4 71.4 personnel disorder n6 n=6 (n=60 n9 n=9 (n=98 n3 n=3 3 (n=35 n=5 n5 5 (n=5 161 61 1,6 75.0 64.2 74.2 76. 66.6 58.8 80.7 71. n= (n=6 (n=9 (n=3 (n= 16 1, 75. 64. 74. 66. 58. 80. (n

RESUMO Os objetivos deste estudo foram analisar dados sobre a atividade física e o tempo de ruminação monitorados através de coleiras na fazenda junto com a produção de leite registrada pelo sistema rotativo de ordenha para prever vacas com base em vários distúrbios utilizando o software de regressão logística binária realizado com o software R. Dados para metrite (n=60), mastite (n=98), manqueira (n=35) e distúrbios digestivos (n=52) foram coletados de 1.618 vacas saudáveis foram usados para construir o modelo de previsão. Para verificar a viabilidade e adaptabilidade do método proposto, analisamos os dados de vacas do mesmo rebanho (rebanho 1) não utilizadas para construir o modelo, e vacas de outro rebanho (rebanho 2) com dados registrados pelo mesmo tipo de sistema automatizado, e levamos à detecção de 75,0%, 64,2%, 74,2%, e 76,9% de animais do rebanho 1 previstos corretamente para sofrer de metrite, mastite, manqueira e distúrbios digestivos, respectivamente. Para as vacas do rebanho 2, 66,6%, 58,8%, 80,7% e 71,4% foram previstos corretamente para metrite, mastite, manqueira e distúrbios digestivos, respectivamente. Em comparação com os diagnósticos clínicos tradicionais feitos pelo pessoal da fazenda, o algoritmo desenvolvido permitiu a previsão antecipada de vacas com um distúrbio. R n=60, n60 n n=60 , 60 (n=60) n=98, n98 n=98 98 (n=98) n=35 n35 35 (n=35 n=52 n52 52 (n=52 1618 618 1.61 proposto 2 automatizado 750 75 0 75,0% 642 64 64,2% 742 74 74,2% 769 76 9 76,9 respectivamente 666 66 6 66,6% 588 58 8 58,8% 807 80 7 80,7 714 71 4 71,4 distúrbio n6 n=6 (n=60 n9 n=9 (n=98 n=3 n3 3 (n=3 n=5 n5 5 (n=5 161 61 1.6 75,0 64,2 74,2 76, 66,6 58,8 80, 71, n= (n=6 (n=9 (n= 16 1. 75, 64, 74, 66, 58, (n

https://doi.org/10.1590/1678-4162-12880

Saúde Cardiovascular e Fibrilação ou Flutter Atrial: Um Estudo Transversal do ELSA-Brasil Atrial ELSABrasil ELSA Brasil
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Santos, Itamar S.

; Lotufo, Paulo A.

; Goulart, Alessandra C.

; Brant, Luisa C. C.

; Pinto Filho, Marcelo M

; Pereira, Alexandre C.

; Barreto, Sandhi M.

; Ribeiro, Antonio L. P.

; Thomas, G Neil

; Lip, Gregory Y. H.

; Bensenor, Isabela M.

; Arasalingam, Ajini

; Beane, Abi

; Bensenor, Isabela M

; Brocklehurst, Peter

; Cheng, Kar Keung

; El-Bouri, Wahbi

; Feng, Mei

; Goulart, Alessandra C

; Greenfield, Sheila

; Guo, Yutao

; Guruparan, Mahesan

; Gusso, Gustavo

; Gooden, Tiffany E

; Haniffa, Rashan

; Humphreys, Lindsey

; Jolly, Kate

; Jowett, Sue

; Kumarendran, Balachandran

; Lancashire, Emma

; Lane, Deirdre A

; Li, Xuewen

; Lip (Co-PI), Gregory Y.H.

; Li, Yan-guang

; Lobban, Trudie

; Lotufo, Paulo A

; Manseki-Holland, Semira

; Moore, David J

; Nirantharakumar, Krishnarajah

; Olmos, Rodrigo D

; Paschoal, Elisabete

; Pirasanth, Paskaran

; Powsiga, Uruthirakumar

; Romagnolli, Carla

; Santos, Itamar S

; Shantsila, Alena

; Sheron, Vethanayagam Antony

; Shribavan, Kanesamoorthy

; Szmigin, Isabelle

; Subaschandren, Kumaran

; Surenthirakumaran, Rajendra

; Tai, Meihui

; Neil Thomas (Co-PI), G

; Varella, Ana C

; Wang, Hao

; Wang, Jingya

; Zhang, Hui

; Zhong, Jiaoyue

Arquivos Brasileiros de Cardiologia

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nov 2022, Volume 119 N. 5 Pages 724 - 731

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background The association between ideal cardiovascular health (ICVH) status and atrial fibrillation or flutter (AFF) diagnosis has been less studied compared to other cardiovascular diseases. Objective To analyze the association between AFF diagnosis and ICVH metrics and scores in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods This study analyzed data from 13,141 participants with complete data. Electrocardiographic tracings were coded according to the Minnesota Coding System, in a centralized reading center. ICVH metrics (diet, physical activity, body mass index, smoking, blood pressure, fasting plasma glucose, and total cholesterol) and scores were calculated as proposed by the American Heart Association. Crude and adjusted binary logistic regression models were built to analyze the association of ICVH metrics and scores with AFF diagnosis. Significance level was set at 0.05. Results The sample had a median age of 55 years and 54.4% were women. In adjusted models, ICVH scores were not significantly associated with prevalent AFF diagnosis (odds ratio [OR]:0.96; 95% confidence interval [95% CI]:0.80-1.16; p=0.70). Ideal blood pressure (OR:0.33; 95% CI:0.15–0.74; p=0.007) and total cholesterol (OR:1.88; 95% CI:1.19–2.98; p=0.007) profiles were significantly associated with AFF diagnosis. Conclusions No significant associations were identified between global ICVH scores and AFF diagnosis after multivariable adjustment in our analyses, at least partially due to the antagonistic associations of AFF with blood pressure and total cholesterol ICVH metrics. Our results suggest that estimating the prevention of AFF burden using global ICVH scores may not be adequate, and ICVH metrics should be considered in separate. (ICVH (AFF diseases ELSABrasil. ELSABrasil ELSA Brasil . (ELSA-Brasil) 13141 13 141 13,14 System center diet, diet (diet activity index smoking glucose Association 005 0 05 0.05 5 544 54 4 54.4 women odds OR0.96 OR096 OR 0.96 96 [OR]:0.96 95 [95 CI0.801.16 CI080116 CI 0.80 1.16 80 1 16 CI]:0.80-1.16 p=0.70. p070 p p=0.70 70 p=0.70) OR0.33 OR033 0.33 33 (OR:0.33 CI0.15–0.74 CI015074 0.15–0.74 15 74 CI:0.15–0.74 p=0.007 p0007 007 OR1.88 OR188 1.88 88 (OR:1.88 CI1.19–2.98 CI119298 1.19–2.98 19 2 98 CI:1.19–2.98 analyses adequate separate (ELSA-Brasil 1314 14 13,1 00 0.0 54. OR0 OR0.9 OR09 096 0.9 9 [OR]:0.9 [9 CI0 801 CI0.801.1 CI08011 080 0.8 116 1.1 8 CI]:0.80-1.1 p07 p=0.7 7 OR0.3 OR03 033 0.3 3 (OR:0.3 CI0.15–0.7 CI01507 015074 0.15–0.7 CI:0.15–0.7 p=0.00 p000 OR1 OR1.8 OR18 188 1.8 (OR:1.8 CI1 CI1.19–2.9 CI11929 119298 1.19–2.9 CI:1.19–2.9 131 13, 0. OR0. 09 [OR]:0. [ CI0.801. CI0801 08 11 1. CI]:0.80-1. p0 p=0. 03 (OR:0. CI0.15–0. CI0150 01507 0.15–0. CI:0.15–0. p=0.0 p00 OR1. 18 (OR:1. CI1.19–2. CI1192 11929 1.19–2. CI:1.19–2. [OR]:0 CI0.801 CI080 CI]:0.80-1 p=0 (OR:0 CI0.15–0 CI015 0150 0.15–0 CI:0.15–0 (OR:1 CI1.19–2 CI119 1192 1.19–2 CI:1.19–2 [OR]: CI0.80 CI08 CI]:0.80- p= (OR: CI0.15– CI01 015 0.15– CI:0.15– CI1.19– CI11 119 1.19– CI:1.19– [OR] CI0.8 CI]:0.80 (OR CI0.15 01 0.15 CI:0.15 CI1.19 1.19 CI:1.19 [OR CI0. CI]:0.8 CI0.1 0.1 CI:0.1 CI1.1 CI:1.1 CI]:0. CI:0. CI1. CI:1. CI]:0 CI:0 CI:1 CI]: CI: CI]

Resumo Fundamento A associação entre o status de saúde cardiovascular ideal ( ideal cardiovascular health ( ICVH) e diagnóstico de fibrilação ou flutter atrial (FFA) foi menos estudado em comparação a outras doenças cardiovasculares. Objetivos Analisar a associação entre o diagnóstico de FFA e métricas e escores de ICVH no Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil). Métodos Este estudo analisou dados de 13141 participantes com dados completos. Os traçados eletrocardiográficos foram codificados de acordo com o Sistema de Minnesota, em um centro de leitura centralizado. As métricas do ICVH (dieta, atividade física, índice de massa corporal, tabagismo, glicemia de jeju, e colesterol total) e escores do ICVH foram calculados conforme proposto pela American Heart Association . Modelos de regressão logística bruta e ajustada foram construídos para analisar associações de métricas e escores do ICVH com diagnóstico de FFA. O nível de significância foi estabelecido em 0,05. Resultados A idade mediana da amostra foi de 55 anos, e 54,4% eram mulheres. Nos modelos ajustados, os escores de ICVH não apresentaram associação significativa com diagnóstico de FFA prevalente [odds ratio (OR):0,96; intervalo de confiança de 95% (IC95%):0,80-1,16; p=0,70). Perfis de pressão arterial ideal (OR:0,33; IC95%:0,1-0,74; p=0,007) e colesterol total ideal (OR:1,88; IC95%:1,19-2,98; p=0,007) foram significativamente associados com o diagnóstico de FFA. Conclusões Não foram identificadas associações significativas entre escores de ICVH global e diagnóstico de FFA após ajuste multivariado em nossas análises, devido, ao menos em parte, às associações antagônicas da FFA com métricas de pressão arterial e de colesterol total do ICVH. Nossos resultados sugerem que estimar a prevenção da FFA por meio de escore de ICVH global pode não ser adequado, e as métricas do ICVH devem ser consideradas separadamente. (FFA cardiovasculares ELSABrasil. ELSABrasil ELSA Brasil (ELSA-Brasil) 1314 completos Minnesota centralizado dieta, dieta (dieta física corporal tabagismo jeju 005 0 05 0,05 5 anos 544 54 4 54,4 mulheres ajustados odds OR0,96 OR096 OR 0,96 96 (OR):0,96 95 IC95%0,801,16 IC95080116 IC IC95% 0,80 1,16 IC95 80 1 16 (IC95%):0,80-1,16 p=0,70. p070 p p=0,70 70 p=0,70) OR0,33 OR033 0,33 33 (OR:0,33 IC95%0,10,74 IC9501074 0,1 0,74 74 IC95%:0,1-0,74 p=0,007 p0007 007 OR1,88 OR188 1,88 88 (OR:1,88 IC95%1,192,98 IC95119298 1,19 2,98 19 2 98 IC95%:1,19-2,98 análises devido parte adequado separadamente (ELSA-Brasil 131 00 0,0 54, OR0 OR0,9 OR09 096 0,9 9 (OR):0,9 801 IC95%0,801,1 IC9508011 080 0,8 116 1,1 IC9 8 (IC95%):0,80-1,1 p07 p=0,7 7 OR0,3 OR03 033 0,3 3 (OR:0,3 10 IC95%0,10,7 IC950107 01 0, 074 0,7 IC95%:0,1-0,7 p=0,00 p000 OR1 OR1,8 OR18 188 1,8 (OR:1,8 192 IC95%1,192,9 IC9511929 119 298 2,9 IC95%:1,19-2,9 13 OR0, 09 (OR):0, IC95%0,801, IC950801 08 11 1, (IC95%):0,80-1, p0 p=0, 03 (OR:0, IC95%0,10, IC95010 07 IC95%:0,1-0, p=0,0 p00 OR1, 18 (OR:1, IC95%1,192, IC951192 29 2, IC95%:1,19-2, (OR):0 IC95%0,801 IC95080 (IC95%):0,80-1 p=0 (OR:0 IC95%0,10 IC9501 IC95%:0,1-0 (OR:1 IC95%1,192 IC95119 IC95%:1,19-2 (OR): IC95%0,80 IC9508 (IC95%):0,80- p= (OR: IC95%0,1 IC950 IC95%:0,1- IC95%1,19 IC9511 IC95%:1,19- (OR) IC95%0,8 (IC95%):0,80 (OR IC95%0, IC95%:0,1 IC95%1,1 IC951 IC95%:1,19 (IC95%):0,8 IC95%0 IC95%:0, IC95%1, IC95%:1,1 (IC95%):0, IC95%:0 IC95%1 IC95%:1, (IC95%):0 IC95%: IC95%:1 (IC95%): (IC95%) (IC95% (IC95 (IC9 (IC

https://doi.org/10.36660/abc.20210970

Saúde Cardiovascular e Fibrilação ou Flutter Atrial: Um Estudo Transversal do ELSA-Brasil
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Santos, Itamar S.

; Lotufo, Paulo A.

; Goulart, Alessandra C.

; Brant, Luisa C. C.

; Pinto Filho, Marcelo M

; Pereira, Alexandre C.

; Barreto, Sandhi M.

; Ribeiro, Antonio L. P.

; Thomas, G Neil

; Lip, Gregory Y. H.

; Bensenor, Isabela M.

; Arasalingam, Ajini

; Beane, Abi

; Bensenor, Isabela M

; Brocklehurst, Peter

; Cheng, Kar Keung

; El-Bouri, Wahbi

; Feng, Mei

; Goulart, Alessandra C

; Greenfield, Sheila

; Guo, Yutao

; Guruparan, Mahesan

; Gusso, Gustavo

; Gooden, Tiffany E

; Haniffa, Rashan

; Humphreys, Lindsey

; Jolly, Kate

; Jowett, Sue

; Kumarendran, Balachandran

; Lancashire, Emma

; Lane, Deirdre A

; Li, Xuewen

; Lip (Co-PI), Gregory Y.H.

; Li, Yan-guang

; Lobban, Trudie

; Lotufo, Paulo A

; Manseki-Holland, Semira

; Moore, David J

; Nirantharakumar, Krishnarajah

; Olmos, Rodrigo D

; Paschoal, Elisabete

; Pirasanth, Paskaran

; Powsiga, Uruthirakumar

; Romagnolli, Carla

; Santos, Itamar S

; Shantsila, Alena

; Sheron, Vethanayagam Antony

; Shribavan, Kanesamoorthy

; Szmigin, Isabelle

; Subaschandren, Kumaran

; Surenthirakumaran, Rajendra

; Tai, Meihui

; Neil Thomas (Co-PI), G

; Varella, Ana C

; Wang, Hao

; Wang, Jingya

; Zhang, Hui

; Zhong, Jiaoyue

Arquivos Brasileiros de Cardiologia

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2022, N. ahead

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210970

Relações entre a Redução de Estrogênio, Obesidade e Insuficiência Cardíaca com Fração de Ejeção Preservada
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Alencar, Allan Kardec Nogueira de

; Wang, Hao

; Oliveira, Gláucia Maria Moraes de

; Sun, Xuming

; Zapata-Sudo, Gisele

; Groban, Leanne

Arquivos Brasileiros de Cardiologia

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dec 2021, Volume 117 N. 6 Pages 1191 - 1201

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A prevalência de obesidade e insuficiência cardíaca com fração de ejeção preservada (ICFEP) aumenta significativamente em mulheres na pós-menopausa. Embora a obesidade seja um fator de risco para disfunção diastólica do ventrículo esquerdo (DDFVE), o mecanismo que liga a interrupção da produção de hormônios ovarianos, especialmente o estrogênio, ao desenvolvimento da obesidade, DDFVE, e ICFEP em mulheres em processo de envelhecimento não é claro. Estudos clínicos e epidemiológicos demonstram que mulheres na pós-menopausa com obesidade abdominal (definida pela circunferência de cintura) têm risco maior de desenvolver a ICFEP do que homens ou mulheres sem obesidade abdominal. Este estudo analisa dados clínicos que corroboram a existência de uma ligação de mecanismo entre a perda de estrogênio mais obesidade e o remodelamento ventricular esquerdo com ICFEP. Ele também discute os possíveis mecanismos celulares e moleculares para a proteção mediada por estrogênio contra tipos de células, depósitos de tecidos, função e metabolismo de adipócitos negativos que podem contribuir para a DDFVE e a ICFEP.

Abstract The prevalence of obesity and heart failure with preserved ejection fraction (HFpEF) increases significantly in postmenopausal women. Although obesity is a risk factor for left ventricular diastolic dysfunction (LVDD), the mechanisms that link the cessation of ovarian hormone production, and particularly estrogens, to the development of obesity, LVDD, and HFpEF in aging females are unclear. Clinical, and epidemiologic studies show that postmenopausal women with abdominal obesity (defined by waist circumference) are at greater risk for developing HFpEF than men or women without abdominal obesity. The study presents a review of clinical data that support a mechanistic link between estrogen loss plus obesity and left ventricular remodeling with LVDD. It also seeks to discuss potential cell and molecular mechanisms for estrogen-mediated protection against adverse adipocyte cell types, tissue depots, function, and metabolism that may contribute to LVDD and HFpEF.

https://doi.org/10.36660/abc.20200855 2 downloads

Valor Prognóstico dos Níveis Plasmáticos de NT-proBNP em Pacientes Hospitalizados com Mais de 80 Anos de Idade em um Hospital em Pequim, China
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Zhu, Qiwei

; Gao, Peng

; Fu, Shihui

; Wang, Hao

; Bai, Yongyi

; Luo, Leiming

; Ye, Ping

Arquivos Brasileiros de Cardiologia

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jun 2021, Volume 116 N. 6 Pages 1027 - 1036

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento Apesar das evidências crescentes de que o peptídeo natriurético N-terminal pró-cérebro (NT-proBNP) tem um valor prognóstico importante em adultos mais velhos, há dados limitados sobre seu valor preditivo prognóstico. Objetivos O objetivo deste estudo é avaliar o significado clínico do NT-proBNP em pacientes hospitalizados com mais de 80 anos de idade em Pequim, China. Métodos Este estudo prospectivo e observacional foi conduzido em 724 pacientes muito idosos em uma enfermaria geriátrica (idade ≥80 anos, variação, 80-100 anos, média, 86,6±3,0 anos). A análise de regressão linear multivariada foi utilizada para rastrear os fatores independentemente associados ao NT-proBNP, e o modelo de regressão de risco proporcional de Cox foi utilizado para rastrear as associações entre os níveis de NT-proBNP e os principais endpoints . Os principais endpoints avaliados foram mortes por todas as causas e ECAM. Valores de p <0,05 foram considerados estatisticamente significativos. Resultados As taxas de prevalência de doença cardíaca coronariana, hipertensão e diabetes mellitus foram 81,4%, 75,1% e 41,2%, respectivamente. O nível médio de NT-proBNP foi 770±818 pg/mL. Utilizando análises de regressão linear multivariada, foram encontradas correlações entre o NT-proBNP plasmático e índice de massa corporal, fibrilação atrial, taxa de filtração glomerular estimada, diâmetro do átrio esquerdo, fração de ejeção do ventrículo esquerdo, uso de betabloqueador, níveis de hemoglobina, albumina plasmática, triglicérides, creatinina sérica, e nitrogênio uréico no sangue. O risco de morte por todas as causas (HR, 1,63; IC 95%, 1,005-2,642; p = 0,04) e eventos cardiovasculares adversos maiores (ECAM; HR, 1,77; IC 95%, 1,289-3,531; p = 0,04) no grupo com o nível mais alto NT-proBNP foi significativamente maior do que no grupo com NT-proBNP mais baixo, de acordo com os modelos de regressão de Cox após o ajuste para vários fatores. Como esperado, os parâmetros da ecocardiografia ajustaram o valor prognóstico do NT-proBNP no modelo. Conclusões O NT-proBNP foi identificado como um preditor independente de morte por todas as causas e ECAM em pacientes hospitalizados com mais de 80 anos de idade.

Abstract Background Despite growing evidence that N-terminal pro-brain natriuretic peptide (NT-proBNP) has an important prognostic value in older adults, there is limited data on its prognostic predictive value. Objectives The aim of this study is to evaluate the clinical significance of NT-proBNP in hospitalized patients older than 80 years of age in Beijing, China. Methods This prospective, observational study was conducted in 724 very elderly patients in a geriatric ward (age ≥80 years, range, 80100 years, mean, 86.6 3.0 years). Multivariate linear regression analysis was used to screen for factors independently associated with NT-proBNP, and the Cox proportional hazard regression model was used to screen for relationships between NT-proBNP levels and major endpoints. The major endpoints assessed were all-cause death and MACEs. P values < 0.05 were considered statistically significant. Results The prevalence rates of coronary heart disease, hypertension, and diabetes mellitus were 81.4%, 75.1%, and 41.2%, respectively. The mean NT-proBNP level was 770 ± 818 pg/mL. Using multivariate linear regression analyses, correlations were found between plasma NT-proBNP and body mass index, atrial fibrillation, estimated glomerular filtration rate, left atrial diameter, left ventricular ejection fraction, use of betablocker, levels of hemoglobin, plasma albumin, triglycerides, serum creatinine, and blood urea nitrogen. The risk of all-cause death (HR, 1.63; 95% CI, 1.0052.642; P = 0.04) and major adverse cardiovascular events (MACE; HR, 1.77; 95% CI, 1.2893.531; P = 0.04) in the group with the highest NT-proBNP level was significantly higher than that in the group with the lowest level, according to Cox regression models after adjusting for multiple factors. As expected, echocardiography parameters adjusted the prognostic value of NT-proBNP in the model. Conclusions NT-proBNP was identified as an independent predictor of all-cause death and MACE in hospitalized patients older than 80 years of age.

https://doi.org/10.36660/abc.20190158 195 downloads

Identification of key genes for type 1 diabetes mellitus by network-based guilt by association
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Li, Shan-Shan

; Tian, Jia-Mei

; Wei, Tong-Huan

; Wang, Hao-Ren

Revista da Associação Médica Brasileira

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jun 2020, Volume 66 N. 6 Pages 778 - 783

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO O objetivo deste estudo é realizar uma inferência funcional genética baseada na rede de coexpressão (CEN), expandindo o escopo do princípio de “Culpa por Associação” (GBA - Guilt by Association) para prever as funções genéticas do diabetes mellitus tipo 1 (T1DM). MÉTODOS Primeiro, os dados transcritos do T1DM foram recuperados do repositório de dados genômicos para a análise dos genes diferenciais (DEGs), e foi gerada uma CEN diferencial ponderada. A área sob a curva ROC (AUC) foi escolhida para determinar a métrica de desempenho para cada termo de Ontologia Genética (GO). A análise da expressão diferencial identificou 325 DEGs no T1DM, e a análise de coexpressão gerou uma CEN diferencial com aresta de peso >0,8. RESULTADOS Um total de 282 anotações de GO com DEGs >20 foram mantidas para inferência funcional. Ao calcular a pontuação de multifuncionalidade dos genes, a inferência da função genética foi realizada para identificar as funções genéticas ideais para T1DM com base na lista de classificação genética ideal. Considerando um valor de AUC >0,7, foram identificadas seis funções genéticas ideais para a T1DM, tais como a regulação do processo imunológico e da atividade dos receptores. CONCLUSÕES A inferência funcional genética baseada em CEN, ao expandir o princípio de GBA, previu seis funções genéticas ideais para o T1DM. Os resultados podem ser caminhos potenciais para tratamentos terapêuticos ou preventivos do T1DM.

SUMMARY OBJECTIVE This study aimed to propose a co-expression-network (CEN) based gene functional inference by extending the “Guilt by Association” (GBA) principle to predict candidate gene functions for type 1 diabetes mellitus (T1DM). METHODS Firstly, transcriptome data of T1DM were retrieved from the genomics data repository for differentially expressed gene (DEGs) analysis, and a weighted differential CEN was generated. The area under the receiver operating characteristics curve (AUC) was chosen to determine the performance metric for each Gene Ontology (GO) term. Differential expression analysis identified 325 DEGs in T1DM, and co-expression analysis generated a differential CEN of edge weight > 0.8. RESULTS A total of 282 GO annotations with DEGs > 20 remained for functional inference. By calculating the multifunctionality score of genes, gene function inference was performed to identify the optimal gene functions for T1DM based on the optimal ranking gene list. Considering an AUC > 0.7, six optimal gene functions for T1DM were identified, such as regulation of immune system process and receptor activity. CONCLUSIONS CEN-based gene functional inference by extending the GBA principle predicted 6 optimal gene functions for T1DM. The results may be potential paths for therapeutic or preventive treatments of T1DM.

https://doi.org/10.1590/1806-9282.66.6.778 726 downloads

Impact of post-thoracotomy analgesia with dexmedetomidine and morphine on immunocytes: a randomized clinical trial
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Lei, Pengfei

; Wang, Jin

; Gao, Shan

; Du, Bo

; Wang, Hao

; Li, Weichun

; Shi, Fei

; Shan, Aijun

Revista Brasileira de Anestesiologia

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apr 2020, Volume 70 N. 2 Pages 153 - 158

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Estudar o impacto em linfócitos causado pelo uso da dexmedetomidina associada à morfina para analgesia pós-toracotomia. Método Um total de 118 pacientes utilizando Analgesia Intravenosa Controlada pelo Paciente (AICP) pós-toracotomia em nosso hospital, de março de 2016 a julho de 2018, foram selecionados aleatoriamente e divididos em dois grupos: o Grupo Combinado [COM, 57 pacientes que receberam dexmedetomidina (1,0 µg.kg-1 de peso corpóreo) associada à morfina (0,48 mg.kg-1 de peso corpóreo)] e o Grupo Morfina [MOR, 61 pacientes, que receberam somente morfina (0,48 mg.kg-)]. Os valores dos subconjuntos de linfócitos (CD3+, CD4+ e CD8+) e das células NK no sangue periférico desses dois grupos foram medidos por citometria de fluxo FACSCalibur em diferentes momentos do estudo [antes da indução anestésica (T0), imediatamente após extubação traqueal (T1), 12 horas após a cirurgia (T2), 24 horas após a cirurgia (T3), 48 horas após a cirurgia (T4), 72 horas após a cirurgia (T5) e 7 dias após a cirurgia (T6)]. As doses de morfina do momento T3 ao T5 e as reações adversas entre os dois grupos também foram registradas e comparadas. Resultados O nível de CD3+ e a razão CD4+/CD8+ de T2 a T5, e o nível de CD4+ e as células NK de T3 a T5 do Grupo COM foram significantemente maiores (p< 0,05) quando comparados ao Grupo MOR. A dose de morfina no pós-operatório e a incidência de prurido, náusea e vômito no pós-operatório foram significantemente menores no grupo MOR (p< 0,05). Conclusões Dexmedetomidina combinada com morfina para AICP no período pós-toracotomia pode melhorar a função dos linfócitos, reduzir o consumo de morfina e diminuir reações adversas durante a analgesia.

Abstract Objective This study aimed to investigate the impact of post-thoracotomy analgesia with dexmedetomidine and morphine on immunocytes. Methods A total of 118 patients with post-thoracotomy Patient-Controlled Intravenous Analgesia (PCIA) in our hospital from March 2016 to July 2018 were randomly selected and divided into the Composite (COM) Group (57 patients administered with dexmedetomidine [1.0 µg.kg-1 body weight] and morphine [0.48 mg.kg-1 body weight]) and the Morphine (MOR) group (61 patients administered with morphine [0.48 mg.kg-1]). The values of lymphocyte subsets (CD3+, CD4+, and CD8+) and Natural Killer cells in the peripheral blood of these two groups were detected by FACSCalibur flow cytometry at different time points (before anesthesia induction [T0], immediately after tracheal extubation [T1], 12 hours after surgery [T2], 24 hours after surgery [T3], 48 hours after surgery [T4], 72 hours after surgery [T5], and 7 days after surgery [T6]). The doses of morphine at T3 to T5 and the adverse reactions between the two groups were also recorded and compared. Results The CD3+ level and the CD4+/CD8+ ratio at T2 to T5 and the CD4+ level and NK cells at T3 to T5 were significantly higher in the COM Group than in the MOR Group (p< 0.05). The postoperative morphine dose and the incidence of postoperative itching, nausea, and vomiting were significantly lower in the COM Group than in the MOR Group (p< 0.05). Conclusions Dexmedetomidine combined with morphine for post-thoracotomy PCIA can improve the function of immunocytes, reduce morphine consumption, and reduce the adverse reactions during analgesia induction.

https://doi.org/10.1016/j.bjane.2020.04.017 310 downloads

10.

Experimental Study on Static and Dynamic Compression Mechanical Properties of Filled Rock Joints
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Chai, Shaobo

; Wang, Hao

; Yu, Liyuan

; Shi, Jiehui

; Abi, Erdi

Latin American Journal of Solids and Structures

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2020, Volume 17 N. 3 elocation e264

Abstract: En | Text: En | PDF: En

Abstract The static and dynamic compression mechanical properties of the prefabricated artificial filled rock joints specimens with different fillings and different joint thicknesses are tested, respectively. Then, the strength, deformation, wave propagation and energy dissipation laws of the filled joints are analyzed. The experimental results show that the static and dynamic compression strength of filled joints increases with the strength of filling materials while decreases with the filling thickness. The deformation characteristics of filled joints under static and dynamic compression are positively correlated with the properties of filling materials and the thickness of filled joints. With the increasing of the filling thickness, the reflection coefficient increases while the transmission coefficient decreases. With the increase of the strength of the fillings, the reflection coefficient decreases while the transmission coefficient increases. The energy dissipation ratio decreases with the increase of the filliing thickness and increases with the increase of the strength of the filling material.

https://doi.org/10.1590/1679-78255988 770 downloads

11.

ANALYSIS OF THE CLINICAL CHARACTERISTICS OF PERIANAL FISTULISING CROHN’S DISEASE IN A SINGLE CENTER
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XU, Min-Min

; ZHU, Ping

; WANG, Hao

; YANG, Bo-Lin

; CHEN, Hong-Jin

; ZENG, Li

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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2019, Volume 32 N. 1 elocation e1420

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Racional: As características clínicas são fundamentais para melhorar a identificação e o tratamento da doença de Crohn (DC), de modo que a análise da amostra seja de grande valor. Objetivo: Explorar as características clínicas da DC fistulizante perianal. Métodos: Análise de 139 casos focados em seus dados clínicos. Resultados: A proporção de homens e mulheres foi de 3,3: 1; a média de idade de 28,2 anos; 47,5% dos pacientes tiveram fístula anal antes do diagnóstico de DC. Pacientes com cirurgia perianal prévia e medicação representaram 64,7% e 74,1%, respectivamente. O tipo de lesão L3 estava presente em 49,6% e os tipos B1 e B2, em 51,8% e 48,2%, respectivamente; fístula anal complexa foi diagnosticada em 90,6%. Sintomas de diarréia foram encontrados em 46% e lesões perianais isoladas em 29,5% dos pacientes. Valores anormais de IMC estavam presentes em 44,6%; índice de atividade DC ativa em 64,7%; e 94,2% tinham índice de atividade de doença perianal ativo. Proporção significativa de pacientes tinha proteína-C reativa, taxa de sedimenta do eritrócito, plaquetas hemoglobina e albumina anormais. Conclusão: Sugere-se que pacientes com fístula anal associada às essas características clínicas alertem a equipe médica para a possibilidade de DC, que deve ser investigada por endoscopia e exame de imagem do trato digestivo para evitar dano na função anal pela operação que rotineiramente é realizada no tratamento da fístula anal.

ABSTRACT Background: Clinical characteristics are keys to improve identification and treatment of Crohn´s disease (CD) so that large sample analysis is of great value. Aim: To explore the clinical characteristics of perianal fistulising CD. Methods: Analysis of 139 cases focused on their clinical data. Results: The proportion of males and females is 3.3:1; the mean age is 28.2 years; 47.5% of patients had anal fistula before CD diagnosis. Patients with prior perianal surgery and medication accounted for 64.7% and 74.1% respectively. The L3 type of lesion was present in 49.6% and the B1 and B2 types for 51.8% and 48.2% respectively; complex anal fistula was diagnosed in 90.6%. Symptoms of diarrhea were found in 46% and perianal lesions alone in 29.5% of patients. Abnormal BMI values was present in 44.6%; active CD activity index in 64.7%; and 94.2% had active perianal disease activity index. A proportion of patients manifest abnormal C-reactive protein, erythrocyte sedimentation rate, platelet, hemoglobin and albumin. Conclusion: We suggest that patients with anal fistula associated to these clinical features should alert the medical team to the possibility of CD, which should be further investigated through endoscopy and imaging examination of alimentary tract to avoid the damage of anal function by routine anal fistula surgery.

https://doi.org/10.1590/0102-672020180001e1420 2784 downloads

12.

Efficacy and safety of sitagliptin added to metformin and insulin compared with voglibose in patients with newly diagnosed type 2 diabetes
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Shi, Chunhong

; Zhang, Ru

; Bai, Ran

; Liu, Dan

; Wang, Yongbo

; Zhang, Xueyang

; Wang, Hao

; Du, Jianling

Clinics

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2019, Volume 74 elocation e736

Abstract: En | Text: En | PDF: En

OBJECTIVE: To assess the efficacy and safety of sitagliptin compared with voglibose added to combined metformin and insulin in patients with newly diagnosed type 2 diabetes (T2DM). METHODS: In this 12-week prospective, randomized, parallel trial, 70 newly diagnosed T2DM patients with glycosylated hemoglobin (HbA1c) ≥9% and/or fasting plasma glucose (FPG) ≥11.1 mmol/L were randomized (1:1) to receive sitagliptin 100 mg per day + metformin + insulin glargine or voglibose 0.2 mg three times daily + metformin + insulin glargine. Change in HbA1c at week 12 was the primary endpoint. RESULTS: The mean baseline HbA1c was 11.0% in the patients. The changes in HbA1c from baseline were -6.00% in the sitagliptin group and -3.58% in the voglibose group, and the between-group difference was -2.42% (95% CI -1.91 to -2.93, p=0.02). The differences in FPG and homeostatic model assessment of β-cell function (HOMA-β) and the change in body weight between groups from baseline were -2.95 mmol/L (p=0.04), 43.91 (p=0.01) and -2.23 kg (p=0.01), respectively. One patient (2.9%) in the sitagliptin group and three patients (8.6%) in the voglibose group exhibited hypoglycemia. CONCLUSIONS: Sitagliptin added to combined metformin and insulin therapy showed greater efficacy and good safety regarding hypoglycemia in patients with newly diagnosed T2DM compared with voglibose.

https://doi.org/10.6061/clinics/2019/e736 1838 downloads

13.

Effects of propofol pretreatment on myocardial cell apoptosis and SERCA2 expression in rats with hepatic ischemia/reperfusion
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Yu, Shuzhen

; Guo, Yongqing

; Zhang, Weiwei

; Zheng, Lina

; Ren, Junming

; Jin, Jianmin

; Yu, Baofeng

; Zhang, Yu

; Wang, Hao

; Zhang, Yuhong

Revista Brasileira de Anestesiologia

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nov 2018, Volume 68 N. 6 Pages 591 - 596

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução: A lesão hepática por isquemia-reperfusão é um processo fisiopatológico comum em cirurgias hepáticas. Mais estudos ainda são necessários para avaliar se o propofol pode reduzir a lesão de isquemia-reperfusão miocárdica induzida pela lesão de isquemia-reperfusão hepática em ratos, juntamente com os mecanismos que estão relacionados. Objetivo: Investigar se propofol protege as células do miocárdio da apoptose com a lesão hepática por isquemia-reperfusão. Métodos: Ratos machos da raça Sprague-Dawley (n = 18) foram alocados aleatoriamente em três grupos: Grupo Sham (Grupo S, n = 6), Grupo Lesão Hepática por Isquemia-reperfusão (Grupo IR, n = 6) e Grupo Propofol (Grupo P, n = 6). O Grupo S foi submetido apenas à laparotomia. O grupo IR foi submetido à isquemia por 30 min e reperfusão por 4 h. O grupo P foi submetido à mesma isquemia do grupo IR, com a administração de 120 mg.kg-1 de propofol iniciada 10min antes da isquemia, seguida de infusão contínua a 20 mg.kg-1.h-1. A apoptose celular foi examinada por meio do ensaio de marcação de terminações dUTP pela deoxinucleotidil transferase. Retículo endoplasmático Ca2+-ATPase2 (SERCA2) e caspase-3 do ácido aspártico contendo cisteína (caspase-3 clivada) foram avaliados com o ensaio western blot e reação em cadeia da polimerase. Resultados: A taxa de apoptose foi maior com mRNA e proteína de SERCA2 regulados para baixo e caspase-3 clivada suprarregulada no Grupo IR, em comparação com o Grupo S (p < 0,01). A taxa de apoptose foi menor com mRNA e proteína de SERCA2 suprarregulada e caspase-3 clivada sub-regulada no Grupo P, em comparação com o Grupo IR (p < 0,01). Conclusões: O propofol pode reduzir a apoptose de células miocárdicas induzida por lesão hepática por isquemia-reperfusão. Entretanto, pode suprarregular o mRNA e a proteína de SERCA2 em ratos.

Abstract Introduction: Hepatic ischemia-reperfusion injury is a common pathophysiological process in liver surgery. Whether Propofol can reduce myocardial ischemia-reperfusion injury induced by hepatic ischemia-reperfusion injury in rats, together with related mechanisms, still needs further studies. Objective: To investigate if propofol would protect the myocardial cells from apoptosis with hepatic ischemia-reperfusion injury. Methods: Male Sprague-Dawley rats (n = 18) were randomly allocated into three groups: Sham Group (Group S, n = 6), Hepatic Ischemia-reperfusion Injury Group (Group IR, n = 6) and Propofol Group (Group P, n = 6). Group S was only subjected to laparotomy. Group IR was attained by ischemia for 30 min and reperfusion for 4 h. Group P was subjected identical insult as in Group IR with the administration of propofol started 10 min before ischemia with 120 mg.kg−1, following by continuous infusion at 20 mg.kg−1.h−1. Cell apoptosis was examined by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay. Endoplasmic reticulum Ca2+-ATPase2 (SERCA2) and cysteine-containing aspartic acid cleaved-caspase3 (cleaved-caspase3) were assayed by western blot and Altimeter polymerase chain reaction. Results: Apoptosis rate was increased, with mRNA and protein of SERCA2 down-regulated and cleaved-caspase3 up-regulated in Group IR compared with Group S (p < 0.01). Apoptosis rate was decreased, with mRNA and protein of SERCA2 up-regulated and cleaved-caspase3 down-regulated in Group P compared with Group IR (p < 0.01). Conclusions: Propofol can reduce hepatic ischemia-reperfusion injury-induced myocardial cell apoptosis, meanwhile, can up-regulate mRNA and protein of SERCA2 in rats.

https://doi.org/10.1016/j.bjane.2018.07.001 642 downloads

14.

Crack Propagation Analysis of Magnesium Rod Processed by Extrusion-shear: Numerical Modeling and Experimental Verification
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Hu, Hong Jun

; Wang, Hao

; Zhang, Ding Fei

; Dai, Qingwei

; Dai, Jin Lin

; BoYang, Ming

Materials Research

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aug 2015, Volume 18 N. 4 Pages 873 - 880

Abstract: En | Text: En | PDF: En

During extrusion-shear (ES) process, the surface cracks would be formed in the processed rod for AZ31 magnesium caused by nonhomogeneous metal flow and stress. To reduce the cracks defects, three-dimensional (3D) finite element method (FEM) of ES on a wrought AZ31 magnesium alloy have been performed. ES process experiments have been also conducted to verify the simulation results under the identical conditions. It can be found that the tendency to generate the dead zone is decreased by employing the ES die with the extrusion ratio of 28 comparing to the one with the extrusion ratio of 11.6. With the extrusion ratio 28, the surface stresses of the rod at the die exit are decreased greatly so that the surface cracks are avoided. The ES die with the extrusion ratio of 28 would increase temperature on the rod surface and subsequently result in the sacrifice of the tensile strength of the AZ31 rod. Damage model has been chosen and Cockcroft–Latham damage factor has been set and incorporated into DEFORM software. The simulation results show that the larger extrusion ratio would have the smaller crack propagation. Experimental validation shows that the results of experiments are in accordance with those from computer simulation. The study indicates that FEM can be used confidently for designing ES dies and process parameters in CAE environment for DEFORM software to improve the product quality and productivity by avoiding trail runs.

https://doi.org/10.1590/1516-1439.015815 2575 downloads

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