ABSTRACT BACKGROUND: Adolescence is characterized by complex and dynamic changes, often involving experimentation, including the use of psychotropic substances. Although it is well-established that recreational psychotropic drugs are associated with suicide ideation in adults, evidence of this association in adolescents remains limited. OBJECTIVE: To investigate the relationship between suicide ideation and psychotropic recreational drug use among adolescents. DESIGN AND SETTING: Systematic review with meta-analysis developed at Universidade Federal de Uberlândia (UFU) and Universidade Estadual de Campinas (UNICAMP), Brazil. METHODS: A search across eight electronic databases for observational studies, without language or publication year restrictions, was conducted. The Joanna Briggs Institute tool was used to assess the risk of bias. Random-effects meta-analyses and odds ratios were used to measure the effects. RESULTS: The search yielded 19,732 studies, of which 78 were included in the qualitative synthesis and 32 in the meta-analysis. The findings indicated that suicidal ideation was 1.96 times more likely (95% confidence interval, CI = 1.47; 2.61) for adolescents who used some drug recurrently and 3.32 times more likely (95%CI = 1.86; 5.93) among those who abused drugs. Additionally, adolescents who used cannabis were 1.57 times more likely (95%CI = 1.34; 1.84) to experience suicide ideation compared with non-users, while cocaine users had 2.57 times higher odds (95%CI = 1.47; 4.50). CONCLUSIONS: Psychotropic recreational drug use is associated with suicidal ideation among adolescents regardless of current or previous use, abuse, or type of substance used. SYSTEMATIC REVIEW REGISTRATION: Registered in the PROSPERO database under the identification number CRD42021232360. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021232360. BACKGROUND changes experimentation substances wellestablished well established adults limited OBJECTIVE SETTING metaanalysis meta analysis UFU (UFU UNICAMP, UNICAMP , (UNICAMP) Brazil METHODS studies restrictions conducted bias Randomeffects Random effects metaanalyses analyses RESULTS 19732 19 732 19,73 7 3 metaanalysis. analysis. 196 1 96 1.9 95% 95 (95 interval 1.47 147 47 2.61 261 2 61 332 3.3 95%CI 95CI 1.86 186 86 5.93 593 5 93 Additionally 157 57 1.5 1.34 134 34 1.84 184 84 nonusers, nonusers non users, non-users 257 2.5 4.50. 450 4.50 . 4 50 4.50) CONCLUSIONS abuse REGISTRATION CRD42021232360 CRD https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD42021232360. httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD42021232360 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD https //www.crd.york.ac.uk/prospero/display_record.php ID=CRD42021232360. www crd york ac uk prospero display record php ID https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021232360 (UNICAMP 1973 73 19,7 9 1. (9 1.4 14 2.6 26 6 33 3. 1.8 18 8 5.9 59 15 1.3 13 25 2. 45 4.5 CRD4202123236 phpID https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD42021232360 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD4202123236 wwwcrdyorkacukprosperodisplayrecordphp IDCRD42021232360 IDCRD ID=CRD42021232360 https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD4202123236 197 19, ( 5. 4. CRD420212323 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD4202123236 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD420212323 IDCRD4202123236 ID=CRD4202123236 https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420212323 CRD42021232 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD420212323 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD42021232 IDCRD420212323 ID=CRD420212323 https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021232 CRD4202123 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD42021232 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD4202123 IDCRD42021232 ID=CRD42021232 https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD4202123 CRD420212 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD4202123 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD420212 IDCRD4202123 ID=CRD4202123 https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420212 CRD42021 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD420212 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD42021 IDCRD420212 ID=CRD420212 https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021 CRD4202 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD42021 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD4202 IDCRD42021 ID=CRD42021 https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD4202 CRD420 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD4202 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD420 IDCRD4202 ID=CRD4202 https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420 CRD42 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD420 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD42 IDCRD420 ID=CRD420 https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42 CRD4 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD42 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD4 IDCRD42 ID=CRD42 https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD4 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD4 IDCRD4 ID=CRD4 https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD ID=CRD

Resumo Esse estudo objetivou avaliar as injúrias dentárias traumáticas (IDTs) na dentição permanente entre os pacientes que compareceram ao ambulatório de uma faculdade de odontologia brasileira, durante os últimos 20 anos, e investigar fatores associados à severidade dessas lesões. Os registros clínicos dos pacientes que compareceram a um centro especializado de atendimento em traumatismo dentário no Brasil apresentando pelo menos uma IDT em dente permanente, entre os anos de 2000 e 2019, foram revisados. Os dados registrados foram sexo, idade, arco dental afetado, etiologia, número e tipo dos dentes afetados, e classificação e severidade das IDTs. O diagnóstico e a classificação das IDTs foram baseados nas diretrizes da Associação Internacional de Traumatologia Dentária (AITD). A gravidade das lesões de cada paciente foi definida como leve, moderada ou severa. Estatísticas descritivas, teste qui-quadrado e análises de regressão multinomial foram usadas para avaliar os resultados. O nível de significância foi fixado em 5%. Um total de 837 registros clínicos foi incluído, totalizando 2357 dentes. O sexo masculino foi mais prevalente que o feminino. A idade dos pacientes variou de 5 a 71 anos. Os traumas mais comuns foram avulsão (n=512) e fratura não-complicada do esmalte-dentina (n=488). As análises univariadas mostraram que houve associação estatisticamente significativa entre a faixa etária (p=0,004), etiologia (p=0,000) e número de dentes afetados (p=0,000) com a gravidade do traumatismo dentário. Em conclusão, as IDTs que ocorreram em Piracicaba e região são epidemiologicamente semelhantes aos encontrados em todo o mundo, e que lesões mais graves estão relacionadas à faixa etária, etiologia e número de dentes afetados. (IDTs brasileira 2 200 2019 revisados afetado AITD. AITD . (AITD) leve severa descritivas quiquadrado qui quadrado resultados 5% 83 incluído 235 feminino 7 n=512 n512 n 512 (n=512 nãocomplicada não complicada esmaltedentina esmalte dentina n=488. n488 n=488 488 (n=488) p=0,004, p0004 p p=0,004 , 0 004 (p=0,004) p=0,000 p0000 000 (p=0,000 conclusão mundo 201 (AITD 8 23 n=51 n51 51 (n=51 n48 n=48 48 (n=488 p000 p=0,00 00 (p=0,004 (p=0,00 n=5 n5 (n=5 n4 n=4 4 (n=48 p00 p=0,0 (p=0,0 n= (n= (n=4 p0 p=0, (p=0, (n p=0 (p=0 p= (p= (p

Abstract This study aimed to assess the traumatic dental injuries (TDIs) in permanent dentition among patients who attended at the outpatient clinic of a Brazilian dental school, during the last 20 years, and to investigate factors associated with the severity of these injuries. Clinical records of patients who attended a specialized center for dental trauma care in Brazil presenting at least one TDI in a permanent tooth, between the years 2000 and 2019, were reviewed. The data recorded were sex, age, affected arch, etiology, number, and type of the teeth affected, and classification and severity of the TDIs. The diagnosis and classification of the TDIs were based on the guidelines of the International Association of Dental Traumatology (IADT). The severity of each patient's injuries was defined as mild, moderate, or severe. Descriptive statistics, chi-square and multinomial regression analyses were used to evaluate the results. The significance level was set at 5%. A total of 837 clinical records were included, totaling 2357 teeth. Males were more prevalent than females. The patients' age ranged from 5 to 71 years. The most common traumas were avulsion (n=512) and uncomplicated enamel-dentin fracture (n=488). Univariate analyses showed that there was a statistically significant association between age group (p=0.004), etiology (p=0.000) and number of teeth affected (p=0.000) with severity of dental trauma. In conclusion, TDIs that occurred in Piracicaba and region are epidemiologically similar to those found worldwide, and that more severe injuries are related to age range, etiology and number of teeth affected. (TDIs school 2 tooth 200 2019 reviewed sex arch IADT. IADT . (IADT) patient s mild moderate statistics chisquare chi square results 5% 83 included 235 females 7 n=512 n512 n 512 (n=512 enameldentin enamel dentin n=488. n488 n=488 488 (n=488) p=0.004, p0004 p p=0.004 , 0 004 (p=0.004) p=0.000 p0000 000 (p=0.000 conclusion worldwide range 201 (IADT 8 23 n=51 n51 51 (n=51 n48 n=48 48 (n=488 p000 p=0.00 00 (p=0.004 (p=0.00 n=5 n5 (n=5 n4 n=4 4 (n=48 p00 p=0.0 (p=0.0 n= (n= (n=4 p0 p=0. (p=0. (n p=0 (p=0 p= (p= (p

Abstract Lipolytic substance injections to reduce localized fat have been extensively used because it is a low-invasive method. This review aimed to evaluate the efficacy and safety of deoxycholic acid in submental fat reduction compared to a placebo and investigate the potential industry sponsorship bias in the results of randomized clinical trials on this topic. Ten electronic databases were extensively searched for randomized clinical trials without restriction on language and year of publication. Two reviewers extracted the data and assessed the individual risk of bias in the studies with the RoB 2.0 tool. The industry sponsorship bias was evaluated according to citations in the articles regarding industry funding/sponsorship throughout the texts. Fixed and random effects meta-analyses were performed, and the results were reported in Risk Ratio (RR) at a 95% Confidence Interval (95% CI). The initial search provided 5756 results, of which only five were included. Only two studies had a low risk of bias. All studies showed a potential industry bias. The meta-analysis showed that patients treated with deoxycholic acid had significant positive results for all efficacy outcomes and a higher risk of fibrosis, pain, erythema, numbness, swelling, edema, pruritus, nodules, headache, and paresthesia. The low to moderate certainty of evidence found allows concluding that deoxycholic acid is effective in submental fat reduction, causing well-tolerated adverse effects. However, all eligible studies showed a potential industry bias. lowinvasive invasive method topic publication 20 2 0 2. tool fundingsponsorship funding texts metaanalyses meta analyses performed RR (RR 95 (95 CI. CI . CI) 575 included metaanalysis analysis fibrosis pain erythema numbness swelling edema pruritus nodules headache paresthesia welltolerated well tolerated However 9 (9 57 ( 5