Abstract Neurocutaneous syndromes comprise a heterogeneous group of congenital or hereditary conditions that are known to be associated with the risk of different disorders and complications. Two of the most common neurocutaneous syndromes are Neurofibromatosis type 1 (NF1) and Tuberous Sclerosis Complex (TSC). Although there appears to be a general consensus on the importance of a multidisciplinary approach in managing these cases, there is still very little emphasis in discussions addressed in the literature on the role of dentistry in accordance with the perspective of comprehensive care. Evidence-based propositions, together with a broad discussion of new insights in this regard, should have the ability to strongly impact related future perspectives, aiming for greater advances and better outcomes for these patients. In this review article, the authors discuss updated general aspects of NF1 and TSC, and the potential additional roles of dentistry, in addition to addressing suggestions for actions in dentistry at related levels of care, as well as priorities for future research. complications NF (NF1 TSC. TSC . (TSC) cases care Evidencebased Evidence based propositions regard perspectives patients article research (NF (TSC

Resumen As fissuras labiopalatinas são as malformações craniofaciais mais frequentes na (El labio leporino y el paladar hendido son las malformaciones cranofaciales más frecuentes en la) espécie humana. O processo de reabilitação para indivíduos com fissuras labiopalatinas é muitas vezes longo e requer a (muchas veces es extenso y requiere la) realização de vários procedimentos cirúrgicos. Quase sempre, essas cirurgias são (Generalmente, esas cirugías son) realizadas com o uso de profilaxia antibiótica. No entanto, não há consenso sobre esse assunto (Sin embargo, no hay consenso acerca de esta cuestión), bem como sobre as várias implicações (si bien hay muchas consideraciones) existentes. Assim, levando em consideração o alto custo, as peculiaridades e a novidade tecnológica do uso da (De esta manera, considerando el alto costo, las particularidades y la innovación tecnológica del uso de la) proteína morfogenética óssea recombinante humana tipo- 2 (rhBMP-2) nas cirurgias de enxerto (en las cirugías de injerto) alveolar secundário para o tratamento de indivíduos com fissuras labiopalatinas, foi elaborado este trabalho de revisão narrativa. É discutido neste artigo acerca do uso da (Este artículo presenta la discusión acerca del uso de la) profilaxia antibiótica cirúrgica frente às condições do ambiente bucal, o período pós-operatório e prognóstico para esses indivíduos.

Abstract Cleft lip and palate are the most frequent craniofacial malformations in the in human species. The rehabilitation process for individuals with cleft lip and palate is often long and requires several surgical procedures. Almost always, these surgeries are are performed with the use of antibiotic prophylaxis. However, there is no consensus on this issue, as well as on the various implications that exist. Thus, tthis narrative review article was carried out taking into account the high cost, the peculiarities and the technological novelty of the use of type 2 human recombinant bone morphogenetic protein (rhBMP- 2) in secondary alveolar graft surgeries for the treatment of individuals with cleft lip and palate. Therefore the present article discusses the use of surgical antibiotic prophylaxis in the face of the oral environment conditions, the postoperative period and prognosis for these individuals.