SUMMARY OBJECTIVE: There is an increase in the prevalence of pre-gestational diabetes in the past decades, mainly due to the increase in the prevalence of obesity in the general population and consequently type 2 diabetes among women of reproductive age. METHODS: This study purposed to describe the delivery characteristics, pregnancy complications, and outcomes among women in Serbia with the pre-gestational type 2 diabetes in the past decade, as well as their pregnancy complications, deliveries, and neonatal outcomes. The study included data from all the pregnant women with pre-gestational type 2 diabetes in Belgrade, Serbia during the period between 2010 and 2020. The final sample consisted of 138 patients. RESULTS: More than half, i.e., 70 (50.7%) had a vaginal delivery, while 48 (34.8%) had elective and 20 (14.5%) had emergency caesarean sections. Throughout the period, there was 1 patient with preeclampsia (0.7%), 5 with pregnancy-induced hypertension (3.6%), 7 had newborns with small for gestational age (5.1%), 28 with macrosomia (20.3%), 12 (8.7%) had preterm births, and one-fifth, i.e., 28 (20.3%) of the newborns had Apgar score under 8. CONCLUSION: The present study revealed that women with type 2 diabetes in pregnancy have a significant burden of pregnancy complications, related to pregnancy, delivery, and newborns. OBJECTIVE pregestational pre decades METHODS characteristics complications decade deliveries Belgrade 201 2020 13 patients RESULTS half ie i e i.e. 50.7% 507 50 (50.7% 4 34.8% 348 34 8 (34.8% 14.5% 145 14 (14.5% sections 0.7%, 07 0.7% , 0 (0.7%) pregnancyinduced induced 3.6%, 36 3.6% 3 6 (3.6%) 5.1%, 51 5.1% (5.1%) 20.3%, 203 20.3% 8.7% 87 (8.7% births onefifth, onefifth one fifth, fifth one-fifth (20.3% CONCLUSION 202 i.e 50.7 (50.7 34.8 (34.8 14.5 (14.5 0.7 (0.7% 3.6 (3.6% 5.1 (5.1% 20.3 8.7 (8.7 (20.3 50. (50. 34. (34. 14. (14. 0. (0.7 3. (3.6 5. (5.1 20. (8. (20. (50 (34 (14 (0. (3. (5. (8 (20 (5 (3 (1 (0 ( (2

SUMMARY OBJECTIVE: Our study purposed to examine the complex relationship between low-molecular-weight heparin therapy, multiple pregnancy determinants, and adverse pregnancy outcomes during the third trimester in women with inherited thrombophilia. METHODS: Patients were selected from a prospective cohort of 358 pregnant patients recruited between 2016 and 2018 at the Clinic for Obstetrics and Gynecology, University Clinical Centre of Serbia, Belgrade. RESULTS: Gestational age at delivery (β=-0.081, p=0.014), resistance index of the umbilical artery (β=0.601, p=0.039), and D-dimer (β=0.245, p<0.001) between 36th and 38th weeks of gestation presented the direct predictors for adverse pregnancy outcomes. The model fit was examined using the root mean square error of approximation 0.00 (95%CI 0.00–0.18), the goodness-of-fit index was 0.998, and the adjusted goodness-of-fit index was 0.966. CONCLUSION: There is a need for the introduction of more precise protocols for the assessment of hereditary thrombophilias and the need for the introduction of low-molecular-weight heparin. OBJECTIVE lowmolecularweight low molecular weight therapy determinants thrombophilia METHODS 35 201 Gynecology Serbia Belgrade RESULTS β=0.081, β0081 β β= 0.081, 0 081 (β=-0.081 p=0.014, p0014 p p=0.014 , 014 p=0.014) β=0.601, β0601 601 (β=0.601 p=0.039, p0039 p=0.039 039 p=0.039) Ddimer D dimer β=0.245, β0245 245 (β=0.245 p<0.001 p0001 001 th 000 00 0.0 95%CI 95CI CI 95 0.00–0.18, 000018 0.00–0.18 18 0.00–0.18) goodnessoffit goodness 0998 998 0.998 0966 966 0.966 CONCLUSION 3 20 β=0.081 β008 0081 0.081 08 (β=-0.08 p001 p=0.01 01 β=0.601 β060 60 (β=0.60 p003 p=0.03 03 β=0.245 β024 24 (β=0.24 p<0.00 p000 0. 9 00001 0.00–0.1 1 099 99 0.99 096 96 0.96 2 β=0.08 β00 008 0.08 (β=-0.0 p00 p=0.0 β=0.60 β06 6 (β=0.6 β=0.24 β02 (β=0.2 p<0.0 0000 0.00–0. 09 0.9 β=0.0 β0 (β=-0. p0 p=0. β=0.6 (β=0. β=0.2 p<0. 0.00–0 β=0. (β=-0 p=0 (β=0 p<0 0.00– β=0 (β=- p= (β= p< (β

Abstract Objective: The present study purposed to determine characteristics of ovarian carcinoma and to analyze predictors of survival in patients with ovarian carcinoma. Method: A retrospective cohort study was conducted including the patients with diagnosed ovarian carcinoma treated at the Clinic for Operative Oncology, Oncology Institute of Vojvodina in the period from January 2012 to December 2016. Seventy-two women with ovarian carcinoma were included in the analysis. The data about the histological type of tumor, disease stage, treatment, lymphatic infiltration, and surgical procedure were collected retrospectively, using the database of the institution where the research was conducted (BirPis 21 SRC Infonet DOO – Information System Oncology Institute of Vojvodina). Descriptive statistics and multivariate analysis using Cox proportional hazards model were performed. Results: The univariate Cox regression analysis identified histology, tumor grade, FIGO (International Federation of Gynecology and Obstetrics) stage, NACT (Neoadjuvant Chemotherapy), number of therapy cycles, type of surgery, and chemotherapy response as independent predictors of mortality. Finally, the type of tumor and chemotherapy response had an increased hazard ratio for mortality in the multivariate Cox regression model. Herewith, the percentage of high-grade, advanced-stage ovarian cancer patients with complete response to chemotherapy, absence of recurrent disease, and lymphovascular space invasion were significant predictors of survival in patients with ovarian carcinoma. Conclusions: Herein, emerging data regarding precision medicine and molecular-based personalized treatments are promising and will likely modify the way the authors provide multiple lines of treatments in the near future. Objective Method 201 2016 Seventytwo Seventy two stage treatment infiltration retrospectively BirPis 2 Vojvodina. . Vojvodina) performed Results histology grade International Obstetrics Neoadjuvant Chemotherapy, Chemotherapy , Chemotherapy) cycles surgery Finally Herewith highgrade, highgrade high high-grade advancedstage advanced Conclusions Herein molecularbased molecular based future 20

Abstract Programmed Cell Death-1 (PCD-1) is a key immune checkpoint receptor, which mainly expresses on activated T, B, Dendritic (DC), Natural Killer (NK), and Treg cells. On the surface of activated T-cells, PCD-1 expression is upregulated after the recognition of peripherals antigens by T cells; subsequently, the elevated binding of PD-1 to Programmed Death Ligand-1 (PD-L1) and Programmed Death Ligand-2 (PD-L2) becomes a key step for downstream inhibitory signaling. Although the role of PD-L1 has been evaluated more thoroughly by clinical research, and PD-L1 has also been used more widely in the clinical setting, PD-L2 also plays an important role in the negative regulation of T-cells, one of the necessary conditions that lead to immune tolerance. Expression of PD-L1 either in tumors or in infiltrating immune cells has been verified predominantly by Immunohistochemistry (IHC) in a variety of tumors, suggesting a role for the PD-1/PD-L1 axis as a prognostic trait and therapeutic target across multiple histotypes. The complex interplay between these factors plays a major role in the diffusion and clinical application of PD-L1 IHC assays as predictive biomarkers of response to PD-1/PD-L1 inhibitors. Checkpoint blockades are registered for the treatment of various cancers, including gynecological malignancies. Death1 1 Death- PCD1 PCD (PCD-1 receptor B DC, DC , (DC) NK, NK (NK) Tcells, Tcells cells, T-cells PCD- subsequently PD1 PD PD- Ligand1 Ligand Ligand- PDL1 PDL L1 L (PD-L1 Ligand2 2 PDL2 L2 (PD-L2 signaling PD-L research setting tolerance (IHC PD1/PDL1 PD1PDL1 PDPDL 1/PD PD-1/PD-L histotypes inhibitors cancers malignancies (PCD- (DC (NK (PD-L PD1/PDL PD1PDL 1PD (PCD

Abstract Objectives: Ad fontes, the status of the thyroid gland, and metabolic disturbance lead to the alteration of oxygenation. In pregnancy, it is particularly crucial to possess all predictive parameters. Methods: This cross-sectional study was conducted at the Clinic of Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade, Serbia, between 2017 and 2021 which study included a total of 99 women who had been admitted for preterm delivery and had undergone thyroid analysis, detected Hashimoto thyroiditis, and Oral Glucose Tolerance Test (OGTT) 40 days after delivery and had pathological Homeostatic Model Assessment for Insulin Response (HOMA IR) indices. In the group of urgent patients with preterm delivery, we looked after not only routine Doppler of the umbilical artery, but we measured specific ratios such as the Cerebroplacental ratio (CP). Results: The mean maternal age was 32.23 ± 5.96 years and the mean gestational age was detected as 35.40 ± 2.39 weeks. The delivery was completed vaginally in 77 women (78%) and surgically in 22 (22%). The Mean APGAR score was 8.44 ± 1.18, the mean birth weight was 2666.87 ± 622.17g and the cases undergoing cesarean section had significantly higher values of pulsatility index (1.85 ± 0.27 vs. 1.34 ± 0.31) and CP (1.22 ± 0.26 vs. 0.47 ± 0.17). Conclusions: The introduction of Doppler sonography for blood flow assessment helps to form a complete clinical description of the patient, particularly in conditions where oxidative stress became provocative by the thyroid gland antibodies and gestational diabetes in Thyroidology. Objectives fontes oxygenation pregnancy parameters Methods crosssectional cross sectional Obstetrics Serbia Belgrade 201 202 9 analysis thyroiditis OGTT (OGTT 4 HOMA IR indices artery CP. . (CP) Results 3223 32 23 32.2 596 5 96 5.9 3540 35 35.4 239 2 39 2.3 weeks 7 78% 78 (78% 22%. 22% (22%) 844 8 44 8.4 118 1 18 1.18 266687 2666 87 2666.8 62217g g 622 17g 1.85 185 85 (1.8 027 0 27 0.2 vs 134 34 1.3 0.31 031 31 1.22 122 (1.2 026 26 047 47 0.4 0.17. 017 0.17 17 0.17) Conclusions patient Thyroidology 20 (CP 322 3 32. 59 5. 354 35. 2. (78 (22% 84 8. 11 1.1 26668 266 2666. 62 1.8 (1. 02 0. 13 1. 0.3 03 1.2 12 04 01 0.1 (7 (22 6 (1 ( (2