RESUMO Objetivo: Analisar a associação entre a participação em exercícios físicos relacionados ao fitness (EFRF) e a insatisfação com a imagem corporal (IIC) em adolescentes e avaliar a interação entre os exercícios físicos e o estado nutricional nesta associação. Métodos: Estudo transversal realizado em 2015 com 799 adolescentes (10 a 16 anos) de 14 escolas públicas de Curitiba (PR), Brasil. A IIC foi avaliada por meio do Body Shape Questionnaire e da Escala de Silhuetas. A participação em EFRF foi avaliada pelo Questionário de Atividade Física para Adolescentes e classificada em “não pratica”, “pratica ≤300 minutos/semana” e “pratica >300 minutos/semana”. As regressões de Poisson e logística multinomial, ajustadas por sexo, maturação sexual e estado nutricional, analisaram a associação entre EFRF e IIC. Resultados: A prevalência de IIC foi de 28,3%; 52,4% dos adolescentes queriam reduzir a silhueta e 48,7% não praticavam a EFRF. Adolescentes que praticavam EFRF >300 minutos/semana tiveram prevalência 28% maior para algum nível de IIC (razão de prevalência — RP 1,28; intervalo de confiança de 95% — IC95% 1,08–1,52) e chance 46% menor de querer reduzir silhuetas (OR 0,54; 95IC% 0,35–0,82), comparados aos não praticantes. Não houve interação entre os EFRF e o estado nutricional na associação com IIC. Conclusões: Os adolescentes que praticam EFRF >300 minutos/semana estão mais propensos a apresentar algum nível de IIC e têm menores chances de reportar o desejo de aumentar silhuetas, independentemente do estado nutricional. Objetivo (EFRF (IIC Métodos 201 79 10 (1 1 anos PR, PR , (PR) Brasil Silhuetas pratica, pratica pratica” 300 ≤30 minutossemana minutos semana >30 minutos/semana. . multinomial sexo Resultados 28,3% 283 28 3 524 52 4 52,4 487 48 7 48,7 razão 1,28 128 95 IC95 IC 1,08–1,52 108152 08 46 OR 0,54 054 0 54 95IC 0,35–0,82, 035082 0,35–0,82 35 82 0,35–0,82) praticantes Conclusões 20 ( (PR 30 ≤3 >3 28,3 2 5 52, 48, 1,2 12 9 IC9 1,08–1,5 10815 0,5 05 03508 0,35–0,8 8 ≤ > 28, 1, 1,08–1, 1081 0, 0350 0,35–0, 1,08–1 108 035 0,35–0 1,08– 03 0,35– 1,08 0,35 1,0 0,3

ABSTRACT Objective: The aim of this study was to analyze the association between participation in fitness-related exercises (FRE) and body image dissatisfaction (BID) in adolescents and evaluate the interaction between physical exercise and nutritional status in this association. Methods: A cross-sectional study was conducted in 2015 involving 799 adolescents (10–16 years old) from 14 public schools in Curitiba (PR), Brazil. BID was assessed using the Body Shape Questionnaire and the Silhouette Scale. The FRE was classified as “does not practice,” “practices ≤300 min/week,” and “practices >300 min/week” by the Physical Activity Questionnaire for Adolescents. Poisson and multinomial logistic regressions, adjusted for sex, sexual maturation, and nutritional status analyzed the association of FRE and BID. Results: The BID prevalence was 28.3%; 52.4% of the adolescents wanted to reduce their silhouettes; and 48.7% did not practice FRE. Adolescents who practiced FRE >300 min/week had a 28% higher prevalence for some level of BID (PR 1.28; 95%CI 1.08–1.52) and a 46% lower chance of wanting to reduce silhouettes (OR 0.54; 95%CI 0.35–0.82), compared to nonpractitioners. There was no interaction between FRE and nutritional status in association with BID. Conclusions: The adolescents who practice FRE >300 min/week are likely to have some level of BID and are less likely to report the desire to increase their silhouettes, regardless of their nutritional status. Objective fitnessrelated fitness related (FRE (BID Methods crosssectional cross sectional 201 79 10–16 1016 10 16 (10–1 old 1 PR, PR , (PR) Brazil Scale does practice, practices 300 ≤30 min/week, minweek min week >30 regressions sex maturation Results 28.3% 283 28 3 524 52 4 52.4 487 48 7 48.7 1.28 128 95CI CI 95 1.08–1.52 108152 08 46 OR 0.54 054 0 54 0.35–0.82, 035082 0.35–0.82 35 82 0.35–0.82) nonpractitioners Conclusions 20 10–1 101 (10– 30 ≤3 >3 28.3 2 5 52. 48. 1.2 12 9 1.08–1.5 10815 0.5 05 03508 0.35–0.8 8 10– (10 ≤ > 28. 1. 1.08–1. 1081 0. 0350 0.35–0. (1 1.08–1 108 035 0.35–0 ( 1.08– 03 0.35– 1.08 0.35 1.0 0.3

RESUMO: O estudo das relações genotípicas entre índices de tolerância à seca e caracteres agronômicos de interesse no melhoramento de trigo é útil para traçar estratégias de seleção. Objetivou-se com este trabalho investigar as relações de causa e efeito entre características agronômicas e índices de tolerância à seca via análise de correlações canônicas. Dois ensaios (controle e estresse) foram conduzidos no inverno de 2020 em Viçosa, MG, Brasil. Foram avaliados os caracteres (dias para o espigamento, altura da planta, massa e número de grãos por espiga, massa de cem grãos e rendimento de grãos). Os dados de produtividade dos ensaios de controle e estresse foram utilizados para construir cinco índices de tolerância à seca. Os dados foram submetidos à análise de modelos mistos para estimação dos parâmetros genéticos e predição dos valores genotípicos (REML/BLUP), em seguida, os valores genotípicos foram utilizados para calcular os coeficientes de correlação entre os caracteres. Dois grupos de caracteres foram estabelecidos para o estudo das correlações canônicas, sendo o primeiro grupo constituído pelas variáveis agronômicas e o segundo pelos índices de tolerância à seca. Houve efeito significativo de genótipo para todas as características avaliadas. Os pares canônicos foram significativos, o que indicou a existência de dependência entre os grupos. O caráter dias para o espigamento pode ser utilizado na seleção indireta de genótipos de trigo para tolerância à seca. RESUMO Objetivouse Objetivou se canônicas 202 Viçosa MG Brasil planta espiga grãos. . grãos) REML/BLUP, REMLBLUP REML/BLUP , REML BLUP (REML/BLUP) seguida avaliadas significativos 20 (REML/BLUP 2

ABSTRACT: The study of genotypic relationships between drought tolerance indices and agronomic traits of interest in wheat breeding is useful for designing selection strategies. The objective of this research was to investigate the cause-and-effect relationships between agronomic traits and drought tolerance indices through the analysis of canonical correlations. Two trials (control and stress) were conducted in winter 2020 in Viçosa, MG, Brazil. The traits evaluated were: (days for heading, plant height, mass and number of grains per spike, mass of one hundred grains, and grain yield). Grain yield data from the control and stress conditions were used to construct five drought tolerance indices. The data were subjected to mixed model analysis for estimation of genetic parameters and prediction of genotypic values (REML/BLUP), and then the genotypic values were used to calculate the correlation coefficients between the traits. Two groups of traits were established for the study of canonical correlations, the first group consisting of agronomic traits and the second by drought tolerance indices. There was a significant genotype effect for all evaluated traits. The canonical pairs were significant, which indicated the existence of dependence between the groups. Days to heading trait can be used in the indirect selection of wheat genotypes for drought tolerance. ABSTRACT strategies causeandeffect cause correlations 202 Viçosa MG Brazil days height spike yield. . yield) REML/BLUP, REMLBLUP REML/BLUP , REML BLUP (REML/BLUP) 20 (REML/BLUP 2

ABSTRACT The aim of this study was to characterise the lignocellulosic fractions of pruning waste from tree species showing potential for furniture production in Acaraú, Ceará. The experiment was conducted in a completely randomised, split-plot design, with the plots corresponding to two water regimes (irrigated for one year and irrigated for three years) and the sub-plots to eight tree species, with three replications. The chemical attributes were determined after seven years. Except for the insoluble lignin content, there was a significant effect from the different species in terms of the chemical properties of the wood. The results for the lignocellulosic fractions show the possibility of developing technological ways of adding value to these waste products, especially considering their lignin content. The different species also showed potential for use in producing cellulose pulp, with the exception of Handroanthus impetiginosus due to its high ash content. The results of this study offer new perspectives for future research into the use of forestry waste. Acaraú Ceará randomised splitplot split plot design years subplots sub replications content wood products pulp

ABSTRACT The aim of this study was to evaluate development in the following tree species: Acacia mangium Willd, Anadenanthera colubrina var. cebil (Griseb.) Altschu, Casuarina equisetifolia L. ex J. R. Forst. & G. Forst, Handroanthus impetiginosus (Mart. Ex DC.) Mattos, and Colubrina glandulosa subsp. reitzii (M.C.Johnst.) Borhidi under two water regimes in the Irrigated Perimeter of Baixo Acaraú, in the state of Ceará. The experiment was conducted over seven years, with the factors represented by water regimes, species and periods in an arrangement of split-split plots in a completely randomised design repeated over time with four replications of two plants each. The response variables were total height, diameter at breast height, volume, absolute growth rate in height and diameter, and current and average annual increase in volume. After seven years, the species Acacia mangium, Casuarina equisetifolia, Handroanthus impetiginosus, Anadenanthera colubrina and Colubrina glandulosa presented the following respective mean volumes: 0.62, 0.47, 0.45, 0.31 and 0.29 m3 irrespective of the water regime. Despite a reduction in the growth rates of the species during each period, they remained positive, and growth did not stop. The mean values for volume confirm that the species showed similar growth for the water regimes under study. An irrigated regime of up to one year is therefore suggested for cultivating these species in the Irrigated Perimeter of Baixo Acaraú, Ceará. Willd var Griseb. Griseb (Griseb. Altschu L J R Forst G Mart. Mart (Mart DC. DC Mattos subsp M.C.Johnst. MCJohnst M C Johnst (M.C.Johnst. Acaraú Ceará years splitsplit split volumes 062 0 62 0.62 047 47 0.47 045 45 0.45 031 31 0.3 029 29 0.2 m period positive stop (Griseb M.C.Johnst (M.C.Johnst 06 6 0.6 04 4 0.4 03 3 0. 02 2

Resumo Enquadramento: para qualquer avaliação de pré-participação, um questionário que analise o histórico clínico pessoal de sinais e sintomas e história clínica familiar pode identificar atletas em risco cardiovascular de morte súbita cardíaca. Objetivos: estratificação do risco cardiovascular com recurso a questionário de pré-participação em atletas jovens e veteranos; avaliar a perceção da importância do exame médico-desportivo entre estes dois grupos. Metodologia: estudo observacional transversal quantitativo, com recolha de dados recorrendo a preenchimento de questionário de pré-participação. Amostra constituída por 66 atletas, 36 atletas jovens e 30 atletas veteranos. Análise estatística com recurso ao programa IBM® SPSS Statistics versão 27.0. Resultados: verificou-se diferença significativa no sexo entre atletas jovens e veteranos (ρ=0,047), tempo de prática desportiva federada (ρ=0,022), tipo de desporto praticado (ρ=0,002), razões para realização de eletrocardiograma (ρ=0,002), prescrição de exame cardíaco por médico no passado (ρ=0,025), não se tendo verificado qualquer significância na história familiar e na perceção da importância do exame médico-desportivo entre os dois grupos. Conclusão: quanto maior é a idade, mais alterações poderão estar presentes a nível cardíaco e mais vezes os atletas nessa faixa etária recorrem aos serviços de saúde para realizar exames cardíacos. Os atletas demonstraram ter uma grande perceção em relação à importância do exame médico-desportivo, bem como do eletrocardiograma. Não se deve dispensar a avaliação criteriosa dos atletas tendo em conta a sua idade.

Resumen Marco contextual: para cualquier evaluación de pre-participación, un cuestionario que revise el historial clínico personal de signos y síntomas y el historial clínico familiar puede identificar a los atletas con riesgo cardiovascular de muerte cardíaca súbita. Objetivos: estratificación del riesgo cardiovascular mediante cuestionario pre-participación en deportistas jóvenes y veteranos; evaluar la percepción de la importancia del chequeo médico-deportivo entre estos dos grupos. Metodología: estudio observacional transversal cuantitativo, con recogida de datos mediante cuestionario de pre-participación. Muestra compuesta por 66 atletas, 36 atletas jóvenes y 30 atletas veteranos. Análisis estadístico mediante el programa IBM® SPSS Statistics versión 27.0. Resultados: fue verificada diferencia significativa en el sexo entre los deportistas jóvenes y veteranos (ρ=0,047), tiempo de práctica deportiva federada (ρ=0,022), tipo de deporte practicado (ρ=0,002), motivos para realizar electrocardiograma (ρ=0,002), prescripción de un examen cardíaco por un médico en el pasado (ρ=0,025), no comprobándose significancia en los antecedentes familiares y en la percepción de la importancia del chequeo médico-deportivo entre los dos grupos. Conclusión: cuanto mayor es la edad, más alteraciones se pueden presentar a nivel cardíaco y con mayor frecuencia los atletas de este grupo de edad recurren a los servicios de salud para realizarse exámenes cardíacos. Los deportistas mostraron una gran percepción de la importancia del chequeo médico-deportivo en su práctica deportiva, así como del electrocardiograma. No se debe descartar una valoración cuidadosa de los deportistas teniendo en cuenta su edad.

Objective: To assess nuclear distribution element-like 1 (Ndel1) enzyme activity following acute administration of sodium nitroprusside (sNP) in a rodent model of schizophrenia (SCZ) and in a cohort of chronic SCZ patients. Methods: Ndel1 activity was measured following sNP infusions in spontaneously hypertensive rats (SHR) (2.5 or 5.0 mg/kg) and in a double-blind randomized trial with 15 SCZ patients (0.5 μg/kg/min). Patients were randomized into two groups (group I: n=7; group II: n=8), with one group receiving placebo and the other sNP in phase A. In phase B, the groups switched treatments. sNP was administered as an infusion of 0.5 μg/kg/min, for 4 h, while placebo was a 5% glucose solution infused under the same conditions. The infusions were administered once weekly over 4 weeks. Psychopathology was assessed using the 18-item figure 5 (BPRS-18 – Bech’s version) and the negative subscale of the Positive and Negative Syndrome Scale. Results: Ndel1 activity was significantly reduced after sNP infusion in SHR and in patients receiving sNP (t = 7.756, degrees of freedom [df] = 97, p < 0.0001, dcohen=1.44) compared to placebo. Reduced Ndel1 activity from baseline to the end of infusion was only seen in patients after treatment with sNP. Conclusion: SCZ patients may benefit from adjunctive therapy with sNP and that the Ndel1 enzyme is a candidate biomarker of psychopathology in the disorder. Future research should look into the role of Ndel1 in SCZ and the potential effects of sNP and drugs with similar profiles of action in both animals and patients. Objective elementlike element like Ndel (Ndel1 (sNP (SCZ Methods (SHR 2.5 25 2 (2. 50 0 5. mg/kg mgkg mg kg doubleblind double blind 05 (0. μg/kg/min. μgkgmin μg/kg/min . μg min μg/kg/min) I n=7 n7 n 7 II n=8, n8 n=8 , 8 n=8) A B treatments 0. h conditions weeks 18item item 18 BPRS18 BPRS (BPRS-1 Bechs Bech s version Scale Results t 7756 756 7.756 df [df 97 00001 0001 0.0001 dcohen=1.44 dcohen144 dcohen 44 Conclusion disorder (Ndel 2. (2 (0 n= BPRS1 (BPRS- 775 75 7.75 9 0000 000 0.000 dcohen=1.4 dcohen14 ( (BPRS 77 7.7 00 0.00 dcohen=1. dcohen1 7. 0.0 dcohen=1 dcohen=

Abstract Objective Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and social interaction and by restricted and repetitive patterns of behavior. Some studies have shown that substances derived from Cannabis sativa improve the quality of life of children with ASD without causing serious adverse effects, thus providing an alternative therapeutic option. The objective of this study was to evaluate the efficacy and safety of a cannabis extract rich in cannabidiol (CBD) in children with ASD. Methods In this randomized, double-blind, placebo-controlled clinical trial, 60 children, aged from 5 to 11 years, were selected and divided into two groups: the treatment group, which received the CBD-rich cannabis extract, and the control group, which received the placebo. They both used their respective products for a period of 12 weeks. Statistical analysis was done by two-factor mixed analysis of variance (two-way ANOVA). Results Significant results were found for social interaction (F1,116 = 14.13, p = 0.0002), anxiety (F1,116 = 5.99, p = 0.016), psychomotor agitation (F1,116 = 9.22, p = 0.003), number of meals a day (F1,116 = 4.11, p = 0.04), and concentration (F1,48 = 6.75, p = 0.01), the last of which was only significant in mild ASD cases. Regarding safety, it was found that only three children in the treatment group (9.7%) had adverse effects, namely dizziness, insomnia, colic, and weight gain. Conclusion CBD-rich cannabis extract was found to improve one of the diagnostic criteria for ASD (social interaction), as well as features that often co-exist with ASD, and to have few serious adverse effects. (ASD behavior effects option CBD (CBD randomized doubleblind, doubleblind double blind, blind double-blind placebocontrolled placebo controlled trial 6 1 years groups CBDrich weeks twofactor factor twoway way ANOVA. ANOVA . ANOVA) F1,116 F1116 F F1 116 (F1,11 1413 14 13 14.13 0.0002, 00002 0.0002 , 0 0002 0.0002) 599 99 5.99 0.016, 0016 0.016 016 0.016) 922 9 22 9.22 0.003, 0003 0.003 003 0.003) 411 4 4.11 0.04, 004 0.04 04 0.04) F1,48 F148 48 (F1,4 675 75 6.75 0.01, 001 0.01 01 0.01) cases 9.7% 97 7 (9.7% dizziness insomnia colic gain interaction, interaction) coexist co exist F1,11 F111 (F1,1 141 14.1 0000 0.000 000 59 5.9 92 2 9.2 0.00 00 41 4.1 0.0 F1,4 F14 (F1, 67 6.7 9.7 (9.7 F1,1 F11 14. 5. 9. 4. 0. F1, (F1 6. (9. (F (9 (

RESUMO A periodontite é uma condição clínica inflamatória causada por biofilme disbiótico que resulta em destruição progressiva da inserção periodontal e pode levar a perda do dente caso não seja tratada. Objetivo: Avaliar a eficácia clínica do laser de diodo de alta potência como coadjuvante à instrumentação mecânica em bolsas periodontais de um paciente com periodontite, estádio III, grau C e generalizada. Métodos: Foram examinados 126 sítios de uma paciente, no Laboratório de Pesquisas Clínicas (LabClin) da Universidade Federal de Campina Grande (UFCG) onde foram avaliados os parâmetros de profundidade de sondagem (PS), nível de inserção clínica (NIC) e sangramento à sondagem (SS) no início do estudo e após 3 e 6 meses da terapia básica. Todos os sítios receberam tratamento periodontal não cirúrgico o que corresponde a raspagem e alisamento coronorradicular (RACR) e polimento coronário. As bolsas periodontais profundas com PS ≥ 5 mm, receberam a terapia coadjuvante com luz laser de diodo. Resultados: Houve uma melhora significativa dos parâmetros periodontais de PS, NIC e SS em todos os sítios tratados. Nos que apresentavam PS ≥ 5 mm, os resultados foram similares, com redução estatisticamente significativa PS, PIC e SS antes e após a realização do tratamento. Após 6 meses, todas as bolsas periodontais com PS ≥ 5mm foram reduzidas a valores menores que 3. Conclusão: A irradiação de bolsas profundas, com laser de diodo de alta potência, mostrou-se eficaz como terapia coadjuvante à RACR em paciente com periodontite estádio III, grau C, generalizada. tratada Objetivo III generalizada Métodos 12 LabClin (LabClin UFCG (UFCG , (PS) (NIC (SS básica (RACR coronário mm Resultados tratados similares Conclusão mostrouse mostrou se 1 (PS

ABSTRACT Periodontitis is an inflammatory clinical condition caused by dysbiotic biofilm that results in progressive destruction of periodontal attachment and can lead to tooth loss if left untreated. Objective: To evaluate the clinical efficacy of high-power diode laser as an adjunct to mechanical instrumentation in periodontal pockets of a patient with generalized, stage III, grade C periodontitis. Methods: 126 sites of a patient were examined at the Clinical Research Laboratory (LabClin) of the Federal University of Campina Grande (UFCG), where the parameters of probing depth (PD), clinical attachment level (CAL) and bleeding on probing (BoP) were evaluated at the beginning of the study and after 3 and 6 months of basic therapy. All sites received non-surgical periodontal treatment which corresponds to scaling and root planing (SRP) and coronary polishing. The deep periodontal pockets with PD ≥ 5 mm, received the adjuvant therapy with diode laser light. Results: There was a significant improvement of periodontal parameters of PD, CAL and BoP in all treated sites. In those with PD ≥ 5 mm, the results were similar, with statistically significant reduction of PD, CAL and BoP before and after treatment. After 6 months, all periodontal pockets with PD ≥ 5mm were reduced to values lower than 3. Conclusion: The irradiation of deep pockets with high-power diode laser proved to be effective as adjuvant therapy to SRP in patients with generalized, stage III, degree C periodontitis. untreated Objective highpower high power generalized III periodontitis Methods 12 LabClin (LabClin UFCG, UFCG , (UFCG) (PD) (CAL (BoP nonsurgical non surgical (SRP polishing mm light Results similar Conclusion 1 (UFCG (PD

The aim of this work was to extract and characterize pectin from lyophilized noni pulp (Morinda citrifolia Linn.) at three different pHs using different extractor agents and to evaluate anti-viral activity. The extraction of high yield (acid extraction) was subjected to sulfation procedure. Fourier transform infrared spectroscopy and proton nuclear magneticresonance analysis were used to calculate the degree of methylation of pectin from acid extraction and its sulfated derivative. The data obtained for the degree of methylation of noni pectin and sulfated pectin were 30.3 and 30.7, respectively. Pectin was subjected to acute oral toxicity testing in mice. The results showed that pectin had a pro-inflammatory effect, and sulfated pectin had an anti-inflammatory effect. Both pectins were also evaluated for herpes simplex virus activity in vitro, and although they successfully inhibited virus replication, the sulfated pectins were cytotoxic. Morinda Linn. Linn antiviral anti viral procedure derivative 303 30 3 30. 307 7 30.7 respectively mice proinflammatory pro inflammatory effect antiinflammatory vitro replication cytotoxic

ABSTRACT The new molecules piperidyl dillapiole and propyl ether dillapiole were evaluated in Aedes aegypti as an alternative for the control of populations of this mosquito. A total of 1,690 samples, comprising 780 eggs, 780 larvae and 130 adults, were treated with both substances for 4 h, 24 h and 90 min, respectively. The dillapiole (80 µg/mL), temephos (0.012 µg/mL) as positive control, and the negative control (water + DMSO 0.05%). The 50% lethal concentrations (LC50) of propyl ether dillapiole and piperidyl dillapiole in eggs were 18.07 and 49.97 µg/mL and, in larvae, the LC50 of these substances were 29.15 and 72.93 µg/mL, which caused darkening of the cuticle and displacement of the head. In the adults, the LC50 of the two substances after 90 min was 148.25 and 263.26 µg/mL, respectively. The insertion of the propyl and piperidine radicals into the dillapiole molecule resulted in the substances propyl ether dillapiole and piperidyl dillapiole, both of which had a toxic effect on Ae. aegypti. However, propyl ether dillapiole, which has propylene in its side chain, showed greater ovicidal, larvicidal and adulticidal activity when compared to piperidyl dillapiole. These results are promising as an alternative form of control of Ae. aegypti, which is the primary vector of human arboviruses. mosquito 1690 1 690 1,69 samples 78 13 adults 2 9 respectively 80 (8 µgmL , µg mL 0.012 0012 0 012 (0.01 water 0.05%. 005 0.05% . 05 0.05%) 50 LC (LC50 1807 18 07 18.0 4997 49 97 49.9 LC5 2915 29 15 29.1 7293 72 93 72.9 head 14825 148 25 148.2 26326 263 26 263.2 Ae However chain ovicidal arboviruses 169 69 1,6 7 8 ( 0.01 001 01 (0.0 00 0.05 5 (LC5 180 18. 499 49. 291 29. 729 72. 1482 14 148. 2632 263. 16 6 1, 0.0 (0. (LC 0. (0

Abstract Introduction: Endoscopic retrograde cholangiopancreatog-raphy (ERCP) in patients with Billroth II gastrectomy is still a challenging procedure. The optimal approach, namely the type of endoscope and sphincter management, has yet to be defined. Aim : To compare the efficacy and safety of forward-viewing gastroscope and the side-viewing duodenoscope in ERCP of patients with Billroth II gastrectomy. Methods: We conducted a retrospective, single-center cohort study of consecutive patients with Billroth II gastrectomy submitted to ERCP in an expert center for ERCP between 2005 and 2021. The outcomes assessed were: papilla identification, deep biliary cannulation, and adverse events (AEs). Multivariate anal-ysis was performed to evaluate potential associations and predictors of the main outcomes. Results: We included 83 patients with a median age of 73 (IQR 65-81) years. ERCP was performed using side-viewing duodenoscope in 52 and forward-viewing gastroscope in 31 patients. Patients’ characteristics were similar in the two groups. The global rate of papilla identification was 66% (n = 55). The rate of deep cannulation was 58% considering all patients and 87% in the subgroup of patients in which the papilla major was identified. Cannulation was performed with standard methods in 65% of cases and with needle-knife fistulotomy in 35%. AEs occurred in 4 patients. There was no difference between duodenoscope and gastroscope in papilla identification (64% [95% CI: 51-77] vs. 71% [55-87]). Although not statistically significant, duodenoscope had a lower deep cannulation rate when considering all patients (52% [15-39] vs. 68% [7-35]) and a higher AEs rate (8% [1-15] vs. 0% [0-1]). In a multivariate analysis, the use of gastroscope significantly increased the deep cannulation rate (OR = 152.62 [2.5-9,283.6]). Conclusion: This study demonstrates that forward-viewing gastroscope is at least as effective and safe as side-viewing duodenoscope for ERCP in patients with Billroth II gastrectomy. Moreover, our study showed that gas-troscope is an independent predictor of successful cannulation.

Resumo Introdução: Colangiopancreatografia retrógrada endoscópica (CPRE) em doentes submetidos previamente a gastrectomia com reconstrução Billroth II é ainda um exame desafiante. A melhor abordagem, nomeadamente tipo de endoscópio e a técnica de canulação biliar, ainda não está definida. Objectivo: Comparar a eficácia e segurança do gastroscópio de visão frontal e do duodenoscópio de visão lateral na CPRE de doentes com gastrectomia com reconstrução Billroth II. Métodos: Conduzimos um estudo de coorte retrospectivo e unicêntrico que incluiu consecutivamente doentes com gastrectomia com reconstrução Billroth II submetidos a CPRE num centro de referência para CPRE entre 2005 e 2021. Os outcomes avaliados foram: identificação da papila, canulação biliar profunda e efeitos adversos (EAs). Regressão logística foi realizada para avaliar possíveis associações e preditores dos outcomes. Resultados: Incluímos 83 doentes com uma idade mediana de 73 (IIQ 65-81) anos. A CPRE foi realizada usando duodenoscópio em 52 doentes e usando o gastroscópio de visão frontal em 31 doentes. As características dos doentes foram semelhantes entre os dois grupos. A taxa global de identificação da papila foi de 66% (n = 55). A taxa de canulação profunda foi de 58% considerando todos os doentes e de 87% considerando apenas o subgrupo de doentes nos quais a papila major foi identificada. A canulação foi realizada usando métodos convencionais em 65% e usando fistulotomia com faca em 35% dos doentes. EAs ocorreram em 4 doentes. Não houve diferenças entre duodenoscópio e gastroscópio relativamente à identificação da papila [64% (95% CI: 51-77) vs 71% (55-87)]. Apesar de estatisticamente não significativo, o uso de duodenoscópio teve uma menor taxa de canulação profunda quando considerados todos os doentes [52% (15-39) vs 68% (7-35)] e uma maior taxa de EAs [8% (1-15) vs 0%(0-1)]. Na regressão logística, o uso de gastroscópio sig-nificativamente aumentou a taxa de canulação profunda [OR = 152.62 (2.5-9,283.6)]. Conclusão: Este estudo demonstra que o uso de gastroscópio de visão frontal é pelo menos igualmente eficaz e seguro ao duodenoscópio na CPRE de doentes com gastrectomia com re-construção Billroth II. Para além disso, o nosso estudo demonstrou que o uso de gastroscópio é um predictor independente para canulação.

ABSTRACT It would be incongruous if the school did not keep up with the pace of change in society, constituting Autonomy and Curricular Flexibility (ACF) as a window of opportunity for its innovation. Taking into account the teachers’ perception, this investigation aims to understand the Principal’s role in the implementation of the ACF, reflecting on the impact of transformational leadership in the management of the curriculum. The sample consisted of 172 teachers, who completed a three-part questionnaire, which included the Portuguese version of the Multifactor Leadership Questionnaire (MLQ). Data were analyzed using the Statistical Package for the Social Sciences (SPSS). The results emphasize the involvement of principals in the implementation of the ACF, giving special emphasis to the promotion of inclusive education and the implementation of the school grammar that facilitates the process. Nevertheless, these top leaders leave to the background the involvement of teachers, students, and families, the constitution of educational teams, and the implementation of collaborative work. Markedly characterized by transformational and transactional behaviors, it was possible to conclude that the more directors perform transformational leadership, the greater is the management of the curriculum.

RESUMEN Sería incongruente que la escuela no se mantuviera al ritmo de los cambios en la sociedad, constituyendo la Autonomía y Flexibilidad Curricular (AFC) como una ventana de oportunidad para su innovación. Teniendo en cuenta la percepción de los docentes, esta investigación tiene como objetivo comprender el rol del director en la implementación del AFC, reflexionando sobre el impacto del liderazgo transformacional en la gestión del currículo. La muestra es constituida por 172 profesores, que completaron un cuestionario de tres partes que incluye la versión en portugués del Cuestionario de Liderazgo Transformacional (CLT). Los datos se analizaron utilizando el Statistical Package for the Social Sciences (SPSS). Los resultados enfatizan la participación de los directores en la implementación del AFC, dando especial énfasis a la promoción de la educación inclusiva y la implementación de la gramática escolar que facilita el proceso. Sin embargo, estos máximos dirigentes dejan en segundo plano la implicación de docentes, alumnos y familias, la constitución de equipos educativos y la implementación del trabajo colaborativo. Muy caracterizada por comportamientos transformacionales y transaccionales, fue posible concluir que mientras más directores desempeñan el liderazgo transformacional, mayor es la gestión de las matrices curriculares.

RESUMO Seria incongruente se a escola não acompanhasse o ritmo de mudança da sociedade, constituindo a Autonomia e Flexibilidade Curricular (AFC) uma janela de oportunidades para a sua inovação. Tendo em conta a perceção dos professores, a presente investigação tem como objetivo conhecer o papel do diretor na implementação da AFC, refletindo-se sobre o impacto da liderança transformacional na gestão das matrizes curriculares-base. A amostra foi constituída por 172 docentes, que preencheram um questionário composto por três partes, que incluía a versão portuguesa do Questionário de Liderança Transformacional (QLT). Os dados foram analisados com recursos ao Statistical Package for the Social Sciences (SPSS). Os resultados enfatizam o envolvimento dos diretores na implementação da AFC, dando especial relevo à promoção da educação inclusiva e à gestão da gramática escolar facilitadora do processo. Não obstante, estas lideranças de topo deixam para segundo plano o envolvimento dos docentes, dos alunos e das famílias, a constituição de equipas educativas e a implementação do trabalho colaborativo. Marcadamente caracterizados por comportamentos transformacionais e transacionais, foi possível concluir que quanto mais os diretores desempenham uma liderança transformacional, maior é a gestão das matrizes curriculares-base.

Abstract Introduction: The articulation between primary care and secondary care and the Pulmonology Diagnostic Centers is particularly important in the management of an insidious disease with a great impact on public health such as tuberculosis. The present case highlights the role of the family doctor in the articulation of care and its importance in the identification and guidance of a possible tuberculosis condition. Case description: Female adolescent, 16 years old, with a history of autoimmune thyroiditis under levothyroxine, iron deficiency anemia under supplementation, and anxiety disorder. Refers to a consultation with the family doctor in 2019 due to a cervical adenomegaly with two weeks of evolution, without warning signs, and an anti-inflammatory was prescribed. Referral to pediatric surgery consultation at a central hospital through urgent pediatric care at the referral hospital, due to persistent adenomegaly after empirical antibiotic treatment and normal analytical study. An aspiration biopsy was performed five months later, with discharge from the consultation due to the absence of malignancy, with no other relevant information. Observed in an emergency context at the referral hospital, six months later, due to new cervical adenomegaly, an alert was made by the family doctor after the detection of isolation of Mycobacterium tuberculosis in a lymph node biopsy performed at the central hospital. Consequent follow-up at the Pneumological Diagnosis Center for lymph node and pulmonary tuberculosis, having undergone lymph node excision and under anti-bacillary treatment, with a favorable clinical outcome. Comment: Tuberculosis is a particular clinical challenge due to the diversity of presentations. This case demonstrates the complexity of managing these patients and the importance of creating alerts in case of a positive mycobacteriological result. The role of the family doctor, as it is often the patient's first contact with healthcare and the bridge to other services, entails an important responsibility in identifying these patients and preventing the chain of transmission.

Resumo Introdução: A articulação entre os cuidados de saúde primários e secundários e os Centros de Diagnóstico Pneumológico reveste-se de particular importância na gestão de uma doença insidiosa e com grande impacto na saúde pública como a tuberculose. O presente caso destaca o papel do médico de família na articulação de cuidados e a importância desta para a identificação e orientação de um possível quadro de tuberculose. Descrição do caso: Adolescente do sexo feminino, 16 anos de idade, com antecedentes de tiroidite autoimune sob levotiroxina, anemia ferropénica sob suplementação e perturbação da ansiedade. Recorre a consulta com a médica de família em 2019 por adenomegalia cervical com duas semanas de evolução, sem sinais de alarme, tendo sido prescrito anti-inflamatório. Referenciação a consulta de cirurgia pediátrica de um hospital central, por indicação do atendimento pediátrico urgente do hospital de referência, por persistência da adenomegalia após tratamento antibiótico empírico e estudo analítico normal. Realizada biópsia aspirativa cinco meses depois, com alta da consulta por ausência de malignidade, sem outras informações relevantes. Observada em contexto de urgência no hospital de referência, seis meses depois, por adenomegalias cervicais de novo, tendo sido feito alerta pela médica de família após deteção de isolamento de Mycobacterium tuberculosis em biópsia ganglionar. Consequente seguimento no Centro de Diagnóstico Pneumológico por tuberculose ganglionar e pulmonar, tendo sido submetida a exérese ganglionar e encontrando-se sob tratamento antibacilar, com evolução clínica favorável. Comentário: A tuberculose constitui um particular desafio clínico pela diversidade de apresentações. Este caso demonstra a complexidade da gestão destes doentes e a importância da criação de alertas em caso de resultado micobacteriológico positivo. O papel do médico de família, dado ser frequentemente o primeiro contacto do doente com os cuidados de saúde e a ponte com os restantes serviços, acarreta uma importante responsabilidade na identificação destes doentes e na prevenção da cadeia de transmissão.

Resumo Esta presente pesquisa tem como objetivo o estudo de como o Facebook foi apropriado entre os movimentos sociais antiausteridade em Portugal ao longo da Grande Recessão, num contexto marcado pela emergência das redes sociais digitais. Desta forma, podemos contribuir para o vasto debate em torno do papel das redes sociais digitais na participação política e cívica. Para a prossecução deste objetivo, realizamos uma análise do conteúdo de páginas do Facebook de oito movimentos sociais que se destacaram neste período e entrevistas semiestruturadas com ativistas destes. A principal descoberta feita pelo estudo consiste numa considerável desigualdade de recursos mobilizados nas práticas cívicas no Facebook entre ativistas e cidadãos utilizadores. Isso nos permite perceber que existem fatores que estão a montante, como a condição socioeconômica, educacional e até sofisticação política que impactam na apropriação das ferramentas digitais como o Facebook. Recessão forma cívica destes utilizadores montante socioeconômica

Abstract This research aims to study how Facebook was appropriated among anti-austerity social movements in Portugal during the Great Recession, in a context marked by the emergence of digital social networks. In this way, we can contribute to the vast debate around the role of digital social networks in political and civic participation. To pursue this objective, we carried out content analysis on the Facebook pages of eight social movements that stood out in these period and semi-structured interviews with activists from these. The main finding consists in a considerable inequality of resources mobilised in civic practices on Facebook between activists and citizen users. This allows us to see that there are upstream factors such as socio-economic status, education and even political sophistication that impact on the appropriation of digital tools such as Facebook. antiausterity anti austerity Recession way participation objective semistructured semi structured users socioeconomic socio economic status

RESUMO No Brasil, a semeadura direta, é o mais utilizado na propagação de melancia. Para tanto, o uso de sementes tratadas surge como uma alternativa para melhoria da uniformidade de estandes no plantio. Dessa forma, objetivou-se verificar os efeitos do tratamento com estimulante de crescimento em sementes de melancia (Citrullus lanatus (Thunb.) Matsum & Nakai), cultivar Crimson Sweet, sobre a germinação e o vigor. O delineamento experimental utilizado foi o inteiramente casualizado, com quatro repetições e seis doses do estimulante de crescimento, Agressive Desperta®, 0; 1; 2; 3; 4 e 5 mL kg-1 de sementes de melancia. Avaliou-se a germinação, índice de velocidade de germinação, comprimento das plântulas, massa seca das plântulas, emergência de plântulas em campo e índice de velocidade de emergência de plântulas. O tratamento de sementes de melancia com estimulante de crescimento proporcionou maior velocidade de germinação, comprimento e massa seca de plântulas, diretamente proporcional ao aumento das dosagens. Em condições de campo, houve melhora na porcentagem e velocidade de emergência das plântulas até a dosagem de 3 mL kg-1 de sementes. Dosagens superiores a essa ocasionaram fitotoxidez. Brasil direta tanto plantio forma objetivouse objetivou se Citrullus Thunb. Thunb (Thunb. Nakai, Nakai , Nakai) Sweet vigor casualizado Desperta Desperta® 0 1 2 kg1 kg kg- Avaliouse Avaliou dosagens fitotoxidez (Thunb

ABSTRACT Direct sowing is the most used watermelon propagation method in Brazil. Therefore, the use of treated seeds is an alternative for improving uniformity of plant stands at planting. Thus, the objective of this study was to assess the effects of seed treatments with biostimulant on the germination and vigor of watermelon [Citrullus lanatus (Thunb.) Matsum & Nakai] seeds of the cultivar Crimson Sweet. A completely randomized experimental design with four replications was used. The seed treatments consisted of six biostimulant (Agressive Desperta®) rates (0, 1, 2, 3, 4, and 5 mL kg-1). Seed germination speed index, seedling length, seedling dry weight, seedling emergence in the field, and seedling emergence speed index were evaluated. The treatment of watermelon seeds with biostimulant resulted in increases in seed germination speed and seedling length and dry weight as the biostimulant rate was increased. Seedling percentage and emergence speed increased up to the rate of 3 mL kg-1 under field conditions; however, application of higher rates resulted in phytotoxicity. Brazil Therefore planting Thus Citrullus Thunb. Thunb (Thunb. Nakai Sweet Agressive Desperta® Desperta 0, 0 (0 1 2 4 kg1. kg1 kg . kg-1) evaluated kg- conditions however phytotoxicity (Thunb (