ABSTRACT Introduction: Psoriasis, systemic inflammatory skin disease, has serious adverse consequences for the physical, mental and social well-being of people; its treatments are expensive and with marked adverse effects. Itolizumab, a humanized anti-CD6 monoclonal antibody, acts as an immunomodulator of T cells and plays an important role in its pathogenesis. Objective: To evaluate the efficacy and clinical safety of itolizumab in 80 patients with severe psoriasis vulgaris. Methods: An expanded clinical use program was carried out, promoted by the Molecular Immunology Center. The clinical response was measured by the severity index and area of psoriasis involvement and for effectiveness these elements were combined with safety, through a complementary clinical analysis of the data generated during the induction phase. Absolute numbers, percent and average and association statistics such as Pearson's correlation tests or Lambda's test were used as summary measures. Results: The area of psoriasis involvement analysis showed a rapid and sustained decrease in its values; adverse events related to the administration of the product under investigation prevailed, light onset, very probable and not serious. Conclusions: Itolizumab is safe and effective in 96% of severe psoriatic patients during the induction phase.

RESUMEN Introducción: La psoriasis, enfermedad inflamatoria sistémica de la piel, tiene consecuencias adversas serias para el bienestar físico, mental y social de las personas; sus tratamientos son costosos y con marcados efectos adversos. El itolizumab, anticuerpo monoclonal anti CD6 humanizado, actúa como inmunomodulador de las células T y desempeña un importante papel en su patogénesis. Objetivo: Evaluar la eficacia y la seguridad clínica del itolizumab en 80 pacientes con psoriasis vulgar grave. Métodos: Se realizó un programa de uso clínico expandido, promovido por el Centro de Inmunología Molecular. La respuesta clínica se midió por el índice de gravedad y área de afectación de psoriasis, y para la eficacia se conjugaron estos elementos con los de seguridad, mediante un análisis clínico complementario de los datos generados durante la fase de inducción. Se emplearon como medidas de resumen los números absolutos, el porciento, el promedio y estadísticas de asociación: las pruebas de correlación de de Pearson, de Friedman y la prueba de Lambda. Resultados: El análisis del área de afectación de psoriasis arrojó un rápido y sostenido descenso de sus valores; prevalecieron los eventos adversos relacionados con la administración del producto en investigación, de aparición inmediata, ligeros, muy probables y no serios. Conclusiones: El itolizumab es seguro y eficaz en el 96 % de los pacientes psoriásicos graves durante los esquemas de inducción.

The case of a 75-year-old black man with a health history is presented in this paper. Two years ago he suffered a fall and was injured traumatized in the sacral region, with a small, painless lesion, which increased in size months later. This patient was treated in several care centers with the diagnosis of traumatic exulceration. He received various treatments with no improvement. A skin biopsy was performed at Santiago de Cuba Military Hospital, the result was epidermoid carcinoma. It was a rare case due to the clinical characteristics and location of the lesion.

Se presenta el caso de un hombre de 75 años de edad, de piel negra y con antecedentes de salud hasta hace dos años en que sufre caída y recibe un trauma en la región sacra, donde apareció una lesión pequeña e indolora, la cual meses después aumentó de tamaño. El paciente fue atendido en varios centros asistenciales con el diagnóstico de exulceración traumática. Recibió diversos tratamientos sin mejoría. En el Hospital Militar de Santiago de Cuba se le realizó biopsia de piel cuyo resultado fue carcinoma epidermoide. Constituyó un caso poco frecuente por las características clínicas y la localización de la lesión.

El mantenimiento de la biodiversidad en sitios RAMSAR, a través de actividades de conservación como el ecoturismo, puede ser muy útil para conservar funciones ecológicas. En Bolivia existen muy pocos estudios que incorporen principios de ecología del paisaje dentro de una visión estratégica para el ecoturismo en general y más aún que se enfoquen específicamente a humedales. El objetivo de este estudio fue investigar el grado de fragmentación y conectividad estructural del paisaje para entender los procesos antropogénicos que han influido en los últimos 30 años en Bañados de Isoso (Santa Cruz, Bolivia). Para ello, se utilizaron los mapas de cambio de uso del suelo de las tierras bajas (1976-2005) y se cuantificaron los cambios en distribución espacial de patrones de vegetación y su conectividad mediante ventanas móviles y muestreos espaciales basados en el tamaño típico de un circuito ecoturístico. Los cambios más significativos ocurrieron después de la década de los 90 con reducciones de más de 40% en ambientes naturales en el noroeste y de 20-30% en el sur. El tamaño promedio de los parches se redujo más del 75% y la densidad de los mismos se incrementó más de 20 veces indicando un alto grado de fragmentación. La conectividad se redujo en un 5% entre 1976 y 2005. Nuestros resultados muestran la utilidad de incorporar principios de ecología del paisaje para evaluar el impacto de las actividades humanas en sitios RAMSAR y como éstas pueden ser utilizadas para incentivar la búsqueda de estrategias como el ecoturismo para promover la conservación del paisaje.

Protecting biodiversity in RAMSAR sites through conservation activities, like ecotourism, can be very useful to maintain ecological function. There are very few studies in Bolivia that incorporate landscape ecology as a strategic vision for ecotourism in general, and even less that focus on wetlands systems. The aim of this research was to assess the degree of fragmentation and structural connectivity in the landscape in order to understand the anthropogenic processes that have influenced Bañados de Isoso (Santa Cruz, Bolivia) in the last 30 years. To achieve this we used land use change coverage for the Bolivian lowlands (1976-2005) and we quantified changes in vegetation patterns and connectivity through moving windows and spatial sampling based on the scale of a typical ecotourism circuit. The most significant changes occurred after the 1990s with more than 40% natural habitat loss in the northwest and 10-20% in the south. Mean patch areas decreased by more than 75% and patch density increased over 20 times during the same period, indicating a high degree of fragmentation. Connectivity decreased by 5% between 1976 and 2005. Our results show the value of using landscape metrics to assess the impact of human activities within RAMSAR sites and how these activities can be used to encourage strategies, such as ecotourism, to promote landscape conservation.

normal;" Se presentan dos casos clínicos de fibroma odontogénico periférico (FOP) entidad poco frecuente. Fueron diagnosticados, tratados y seguidos en las Cátedras de Patología, Semiología y Clínica Estomatológica y de Anatomía Patológica Buco-máxilo-facial de la Facultad de Odontología (UDELAR). La baja frecuencia de esta lesión en la literatura y el diagnóstico diferencial que plantea con otras lesiones hace interesante su publicación. Ambos afectaron a mujeres de 6 y 57 años respectivamente

Two case reports of peripheral odontogenic fibroma (POF), a rare clinical lesion, are presented. They were diagnosed, treated and followed at the Departments of Pathology, Semiology and Stomatology Clinic and Pathologic Anatomy Laboratory of Dental Public School, University of Uruguay (UDELAR). Few cases are reported in the literature; the possible differential diagnosis with other clinical entities make it interesting to publish. Both occured in 6 and 57-year-old females respectively

The objective of this paper was to determine the association of a SNP in the µ-calpain gene at position 316 with growth and quality of meat traits of steers grown on pasture. Fifty-nine Brangus and 20 Angus steers were genotyped for CAPN1 316. Warner Bratzler shear force was measured in l. lumborum samples after a 7-day aging period. A multivariate analysis of variance was performed, including shear force (WBSF), final weight (FW), average daily gain (ADG), backfat thickness (BFT), average monthly fat thickness gain (AMFTG), rib-eye area (REA), and beef rib-eye depth (RED) as dependent variables. The CAPN1 316 genotype was statistically significant. Univariate analyses were done with these variables. The marker genotype was statistically significant (p < 0.05) for WBSF (kg: CC: 4.41 ± 0.57; CG: 5.58 ± 0.20; GG: 6.29 ± 0.18), FW (kg: CC: 360.23 ± 14.71; CG: 381.34 ± 5.26; GG: 399.23 ± 4.68), and ADG (kg/d: CC: 0.675 ± 0.046; CG: 0.705 ± 0.016; GG: 0.765 ± 0.014) Shear force, final weight and average daily gain were significantly different according to the CAPN1 316 marker genotypes. The marker genotype was statistically significant in the multivariate analysis (p = 0.001). The first characteristic root explained 89% of the differences among genotypes. WBSF, FW and ADG were the most important traits in the first vector, indicating that animals with the marker genotype for lowest WBSF also have the lowest FW and ADG.

The activity of the calpains/calpastatin proteolytic system is closely related to the postmortem tenderization of meat. We investigated the association between beef tenderness and single nucleotide polymorphism (SNP) markers on the CAPN1 gene (SNP316, alleles C/G; SNP530 alleles A/G) and the CAST gene 3' untranslated region (SNP2870, alleles A/G). We sampled nine slaughter groups comprising 313 steers which had been reared in beef production systems in Argentina between 2002 and 2004 from crosses between Angus, Hereford and Limousin cattle. Minor allele frequencies for the markers were 0.27 to 0.46 (C), 0.02 to 0.18 (A), and 0.24 to 0.53 (A), respectively. The presence of CAPN1 markers had significant effects on meat shear force but no detectable effects were demonstrated for the CAST marker. The shear force of meat from steers with the SNP316 CC genotype was 11% lower than for the SNP316 CG genotype and 17% lower than for the SNP316 GG genotype. There were very few steers with the SNP530 AA genotype and, contrary to previous studies, meat from steers with the SNP530 GG genotype showed an 11.5% higher shear force than that from steers with the SNP530 GA genotype. Final body weight, carcass weight and rib eye area were not affected by any of the markers. These results support the concept that CAPN1 variants are associated with tenderness across a wide range of beef production systems.