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Biological action of melatonin on target receptors in breast cancer
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Pardi, Paulo Celso

; Turri, José Antonio Orellana

; Bayer, Luiza Helena Costa Moreira

; Nóbrega, Gabriela Bezerra

; Filassi, José Roberto

; Simões, Ricardo dos Santos

; Mota, Bruna Salani

; Sorpreso, Isabel Cristina Espósito

; Baracat, Edmund Chada

; Soares Júnior, José Maria

Revista da Associação Médica Brasileira

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2024, Volume 70 N. 3 elocation e20231260

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1806-9282.20231260

Severe atopic dermatitis and dupilumab
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Bernardo, Wanderley

; Bernardo, Luca Silveira

; Baroni, Juliana Hegedus

; Simões, Ricardo dos Santos

Revista da Associação Médica Brasileira

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jan 2023, Volume 69 N. 1 Pages 2 - 6

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1806-9282.023d691

Does bisphenol A (BPA) participates in the pathogenesis of Polycystic Ovary Syndrome (PCOS)? BPA (BPA PCOS (PCOS) (PCOS
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Urbanetz, Lorena Ana Mercedes Lara

; Soares Junior, José Maria

; Maciel, Gustavo Arantes Rosa

; Simões, Ricardo dos Santos

; Baracat, Maria Cândida Pinheiro

; Baracat, Edmund Chada

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2023, Volume 78 elocation 100310

Abstract: En | Text: En | PDF: En

Abstract PCOS is an endocrine disorder characterized by chronic anovulation, hyperandrogenism, and polycystic ovaries. Its etiology is uncertain. It is debated whether BPA would be a component of the environmental factor in the etiology of PCOS. Contamination by BPA can occur from food packaging (exposure during the diet) and through skin absorption and/or inhalation. It can be transferred to the fetus via the placenta or to the infant via breast milk, and it can be found in follicular fluid, fetal serum, and amniotic fluid. The phenolic structure of BPA allows it to interact with Estrogen Receptors (ERs) through genomic signaling, in which BPA binds to nuclear ERα or Erβ, or through nongenomic signaling by binding to membrane ERs, prompting a rapid and intense response. With daily and constant exposure, BPA's tendency to bioaccumulate and its ability to activate nongenomic signaling pathways can alter women's metabolic and reproductive function, leading to hyperandrogenism, insulin resistance, obesity, atherogenic dyslipidemia, chronic inflammatory state, and anovulation and favoring PCOS. The harmful changes caused by BPA can be passed on to future generations without the need for additional exposure because of epigenetic modifications. Not only high BPA levels can produce harmful effects, but at low levels, BPA may be harmful when exposure occurs during the most vulnerable periods, such as the fetal and neonatal periods, as well as during the prepubertal age causing an early accumulation of BPA in the body. Learning how BPA participates in the pathogenesis of PCOS poses a challenge and further studies should be conducted. hyperandrogenism ovaries uncertain diet andor inhalation milk fluid serum ERs (ERs Erβ response BPAs s womens women function resistance obesity dyslipidemia state modifications effects periods body conducted

https://doi.org/10.1016/j.clinsp.2023.100310

Guidelines on sickle cell disease: primary stroke prevention in children and adolescents. Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Guidelines project: Associação Médica Brasileira - 2021
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Loggetto, Sandra Regina

; Veríssimo, Mônica Pinheiro de Almeida

; Darrigo-Junior, Luiz Guilherme

; Simões, Ricardo dos Santos

; Bernardo, Wanderley Marques

; Braga, Josefina Aparecida Pellegrini

Hematology, Transfusion and Cell Therapy

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jan 2022, Volume 44 N. 1 Pages 85 - 94

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.htct.2021.09.013

Systematic review of finasteride effect in women with hirsutism
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Soares Júnior, José Maria

; Guimarães, Daniela Zaros

; Simões, Ricardo dos Santos

; Veiga, Eduardo Carvalho de Arruda

; Roa, Cristiane Lima

; Sorpreso, Isabel Cristina Espósito

; Baracat, Maria Cândida

; Baracat, Edmund Chada

Revista da Associação Médica Brasileira

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jul 2021, Volume 67 N. 7 Pages 1043 - 1049

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1806-9282.20210248 48 downloads

Melatonin and the cardiovascular system in animals: systematic review and meta-analysis
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Veiga, Eduardo Carvalho de Arruda

; Simões, Ricardo dos Santos

; Caviola, Leonardo L.

; Abreu, Luiz Carlos

; Cavalli, Ricardo Carvalho

; Cipolla-Neto, José

; Baracat, Edmund Chada

; Soares Júnior, José Maria

Clinics

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2021, Volume 76 elocation e2863

Abstract: En | Text: En | PDF: En

Melatonin, a hormone released by the pineal gland, demonstrates several effects on the cardiovascular system. Herein, we performed a systematic review and meta-analysis to verify the effects of melatonin in an experimental model of myocardial infarction. We performed a systematic review according to PRISMA recommendations and reviewed MEDLINE, Embase, and Cochrane databases. Only articles in English were considered. A systematic review of the literature published between November 2008 and June 2019 was performed. The meta-analysis was conducted using the RevMan 5.3 program provided by the Cochrane Collaboration. In total, 858 articles were identified, of which 13 were included in this review. The main results of this study revealed that melatonin benefits the cardiovascular system by reducing infarct size, improving cardiac function according to echocardiographic and hemodynamic analyses, affords antioxidant effects, improves the rate of apoptosis, decreases lactate dehydrogenase activity, enhances biometric analyses, and improves protein levels, as analyzed by western blotting and quantitative PCR. In the meta-analysis, we observed a statistically significant decrease in infarct size (mean difference [MD], -20.37 [-23.56, -17.18]), no statistical difference in systolic pressure (MD, -1.75 [-5.47, 1.97]), a statistically significant decrease in lactate dehydrogenase in animals in the melatonin group (MD, -4.61 [-6.83, -2.40]), and a statistically significant improvement in the cardiac ejection fraction (MD, -8.12 [-9.56, -6.69]). On analyzing potential bias, we observed that most studies presented a low risk of bias; two parameters were not included in the analysis, and one parameter had a high risk of bias. Melatonin exerts several effects on the cardiovascular system and could be a useful therapeutic target to combat various cardiovascular diseases.

https://doi.org/10.6061/clinics/2021/e2863 130 downloads

Brazilian Society of Rheumatology 2020 guidelines for psoriatic arthritis
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Carneiro, Sueli

; Palominos, Penelope Esther

; Anti, Sônia Maria Alvarenga

; Assad, Rodrigo Luppino

; Gonçalves, Rafaela Silva Guimarães

; Chiereghin, Adriano

; Lyrio, Andre Marun

; Ximenes, Antônio Carlos

; Saad, Carla Gonçalves

; Gonçalves, Célio Roberto

; Kohem, Charles Lubianca

; Marques, Cláudia Diniz Lopes

; Schainberg, Cláudia Goldenstein

; Meirelles, Eduardo de Souza

; Resende, Gustavo Gomes

; Pieruccetti, Lenise Brandao

; Keiserman, Mauro Waldemar

; Yazbek, Michel Alexandre

; Sampaio-Barros, Percival Degrava

; Lage, Ricardo da Cruz

; Bonfiglioli, Rubens

; Oliveira, Thauana Luíza

; Azevedo, Valderílio Feijó

; Bianchi, Washington Alves

; Bernardo, Wanderley Marques

; Simões, Ricardo dos Santos

; Pinheiro, Marcelo de Medeiros

; Campanholo, Cristiano Barbosa

Advances in Rheumatology

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2021, Volume 61 elocation 69

Abstract: En | Text: En | PDF: En

Abstract Psoriatic arthritis (PsA) is a chronic and systemic immune disease characterized by inflammation of peripheral and/ or axial joints and entheses in patients with psoriasis (PsO). Extra-articular and extracutaneous manifestations and numerous comorbidities can also be present. These recommendations replace the previous version published in May 2013. A systematic review of the literature retrieved 191 articles that were used to formulate 12 recommendations in response to 12 clinical questions, divided into 4 sections: diagnosis, non-pharmacological treatment, conventional drug therapy and biologic therapy. These guidelines provide evidence-based information on the clinical management for PsA patients. For each recommendation, the level of evidence (highest available), degree of strength (Oxford) and degree of expert agreement (interrater reliability) are reported.

https://doi.org/10.1186/s42358-021-00219-y

Ultrasound in the first trimester of pregnancy
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Almeida, Glauce Romeiro de

; Simões, Ricardo dos Santos

; Silvinato, Antonio

; Bernardo, Wanderley Marques

Revista da Associação Médica Brasileira

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nov 2020, Volume 66 N. 11 Pages 1472 - 1472

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1806-9282.66.11.1472 272 downloads

Ultrasound in the first trimester of pregnancy
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Almeida, Glauce Romeiro de

; Simões, Ricardo dos Santos

; Silvinato, Antonio

; Bernardo, Wanderley Marques

Revista da Associação Médica Brasileira

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oct 2020, Volume 66 N. 10 Pages 1323 - 1326

Abstract: En | Text: En | PDF: En

The Guidelines Project, an initiative of the Brazilian Medical Association, aims to combine information from the medical field in order to standardize producers to assist the reasoning and decision-making of doctors. The information provided through this project must be assessed and criticized by the physician responsible for the conduct that will be adopted, depending on the conditions and the clinical status of each patient.

https://doi.org/10.1590/1806-9282.66.7.1323 447 downloads

10.

Are women living with HIV prone to osteoporosis in postmenopause? A systematic review
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Cezarino, Pérsio Yvon Adri

; Simões, Ricardo dos Santos

; Baracat, Edmund Chadat

; Soares Junior, José Maria

Revista da Associação Médica Brasileira

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may 2018, Volume 64 N. 5 Pages 469 - 473

Abstract: En | Text: En | PDF: En

SUMMARY BACKGROUND Some researchers have suggested that HIV infections can increase the cytokines, which might interfere with the bone metabolism and increase the risk of bone mass loss. However, this issue has yet to be consolidated in postmenopausal women. OBJECTIVE To analyze studies that evaluated the loss of bone mass through DEXA in women living with HIV. MATERIALS AND METHODS: A systematic review was conducted following the PRISMA guideline. The MEDLINE, EMBASE and Cochrane databases were consulted from January 1987 to March 2017. Studies assessing bone mineral density (BMD) in postmenopausal women living with HIV were included. The secondary outcome was to evaluate the impact of antiretroviral on BMD. RESULTS Sixty percent of the manuscripts suggested that women living with HIV had more bone loss than women in the control group, mainly in the lumbar spine. Forty percent did not observe any difference between groups. One study reported the influence of antiretroviral drugs on bone mass but did not find any difference between groups. CONCLUSION Our data suggest that HIV infections may have a negative influence on bone mass loss in women. Further studies on the mechanism of this HIV consequence are necessary to clarify the connection as well as the impact of the antiretroviral action on BMD in postmenopausal women.

https://doi.org/10.1590/1806-9282.64.05.469 961 downloads

11.

Chronic pain treatment with spinal cord neurostimulation
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Cukiert, Arthur

; Reis, Alexandre Mac Donald

; Almeida, Antonio Silvinato de

; Simões, Ricardo dos Santos

; Buzzini, Renata F.

; Bernardo, Wanderley Marques

Revista da Associação Médica Brasileira

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apr 2018, Volume 64 N. 4 Pages 299 - 306

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1806-9282.64.04.299 1178 downloads

12.

How to evaluate quality of life in overweight and obese women during climacterium?
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Munhoz, Livia Oliveira

; Sorpreso, Isabel Cristina Esposito

; Nogueira, Maria Cristina Caceres

; Simões, Ricardo dos Santos

; Soares Junior, José Maria

; Baracat, Edmund Chada

Revista da Associação Médica Brasileira

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oct 2014, Volume 60 N. 5 Pages 484 - 489

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivo: identificar os instrumentos utilizados para aferir a qualidade de vida de mulheres com sobrepeso e obesidade no climatério (transição para menopausa e pós-menopausa). Métodos: busca sistemática nas bases de dados Embase, Pubmed e Cochrane com os descritores: menopause/climacteric, quality of life, overweight/obesity. Foram incluídos 19 artigos que preencheram os critérios de inclusão. Resultados: foram identificados 18 questionários genéricos (qualidade de vida global), 6 específicos para menopausa e 1 específico para obesidade. Onze estudos utilizaram instrumentos genéricos, enquanto 8 utilizaram específicos para menopausa. Conclusão: não houve consenso na literatura quanto ao uso de instrumentos de qualidade de vida em mulheres com sobrepeso e obesidade no climatério, o que dificulta a comparação e a reprodutibilidade dos resultados. Este é um alerta quanto à necessidade de padronização para melhor avaliar essa população específica.

Objective: identifying the instruments used to measure quality of life during menopausal transition and post-menopause in women with obesity or overweight. Methods: a systematic search using the Embase, Pubmed and Cochrane databases, and the following key-words: menopause/climacteric, quality of life, overweight/obesity. Nineteen papers that fulfilled the including criteria were found. Results: eighteen studies using generic health questionnaires (global quality of life) were identified, six of them were specific for menopause and one specific for obesity. Eleven studies used generic questionnaires, while only eight questionnaires were specific for menopause. Conclusion: there was no consensus in the literature about the use of quality of life questionnaires in women with overweight and obesity in climacterium, which makes de comparison and reproducibility of the results difficult. This is an alert about the need for standardization to better evaluate this specific population.

https://doi.org/10.1590/1806-9282.60.05.018 2590 downloads

13.

Atualização em anafilaxia: diagnóstico
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Bernardo, Wanderley M.

; Pastorino, Antônio Carlos

; Solé, Dirceu

; Gesu, Giovanni M.S. di

; Tebyriça, João Negreiros

; Bernd, Luiz Antonio G.

; Spindola, Maria Anita Costa

; Rizzo, Maria Cândida Faria Varanda

; Rosário Filho, Nelson Augusto

; Rubini, Norma de Paula Motta

; Simões, Ricardo dos Santos

Revista da Associação Médica Brasileira

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apr 2013, Volume 59 N. 2 Pages 112 - 112

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.1016/j.ramb.2013.01.001 1639 downloads

14.

Atualização em hérnia de disco cervical
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Bernardo, Wanderley M.

; Herrero, Carlos Fernando Pereira da Silva

; Canto, Fabiano Ricardo de Tavares

; Façanha Filho, Fernando Antonio

; Delfino, Helton

; Mudo, Marcelo Luis

; Taricco, Mario Augusto

; Moraes, Osmar J.S.

; Simões, Ricardo dos Santos

; Botelho, Ricardo Vieira

; Neves, Robert

; Zylbersztein, Sérgio

Revista da Associação Médica Brasileira

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feb 2013, Volume 59 N. 1 Pages 14 - 14

Abstract: Pt | Text: Pt | PDF: Pt

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Ultraestrutura do nervo facial intratemporal em pacientes com paralisia facial idiopática: estudo de evidências de infecção viral
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Florez, Rosangela Aló Maluza

; Lang, Raquel

; Veridiano, Adriano Mora

; Zanini, Renato de Oliveira

; Calió, Pedro Luiz

; Simões, Ricardo dos Santos

; Testa, José Ricardo Gurgel

Brazilian Journal of Otorhinolaryngology

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oct 2010, Volume 76 N. 5 Pages 639 - 642

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A etiologia da paralisia facial periférica idiopática (PFPI) ainda é uma incógnita, no entanto, alguns autores aventam a possibilidade de ser uma infecção viral. OBJETIVO: Analisar a ultraestrutura do nervo facial procurando evidências virais que possam nos fornecer dados etiológicos. MATERIAL E MÉTODO: Foram estudados 20 pacientes com PFP, com graus de moderado a severo, de ambos os sexos, entre 18-60 anos, provenientes de Ambulatório de Distúrbios do Nervo Facial. Os pacientes foram divididos em dois grupos: Estudo, onze pacientes com PFPI e Controle, nove pacientes com Paralisia Facial Periférica Traumática ou Tumoral. Foram estudados fragmentos de bainha do nervo facial ou fragmentos de seus cotos, que durante a cirurgia de reparação do nervo facial, seriam desprezados ou encaminhados para estudo anatomopatológico. O tecido foi fixado em glutaraldeído 2% e analisado em Microscopia Eletrônica de Transmissão. RESULTADO: Observamos no grupo estudo atividade celular intensa de reparação com aumento de fibras colágenas, fibroblastos com organelas desenvolvidas, isentos de partículas virais. No grupo controle esta atividade de reparação não foi evidente, mas também não foram observadas partículas virais. CONCLUSÃO: Não foram encontradas partículas virais, no entanto, houve evidências de intensa atividade de reparação ou infecção viral.

The etiology of idiopathic peripheral facial palsy (IPFP) is still uncertain; however, some authors suggest the possibility of a viral infection. AIM: to analyze the ultrastructure of the facial nerve seeking viral evidences that might provide etiological data. MATERIAL AND METHODS: We studied 20 patients with peripheral facial palsy (PFP), with moderate to severe FP, of both genders, between 18-60 years of age, from the Clinic of Facial Nerve Disorders. The patients were broken down into two groups - Study: eleven patients with IPFP and Control: nine patients with trauma or tumor-related PFP. The fragments were obtained from the facial nerve sheath or from fragments of its stumps - which would be discarded or sent to pathology exam during the facial nerve repair surgery. The removed tissue was fixed in 2% glutaraldehyde, and studied under Electronic Transmission Microscopy. RESULTS: In the study group we observed an intense repair cellular activity by increased collagen fibers, fibroblasts containing developed organelles, free of viral particles. In the control group this repair activity was not evident, but no viral particles were observed. CONCLUSION: There were no viral particles, and there were evidences of intense activity of repair or viral infection.

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