Background Few studies compared populations with similar genetic and culture background on different continents with standardized methods. Objective To describe methodological issues of the Study of Health in Pomerode - SHIP-Brazil and some characteristics of the participants of the baseline examination. Design and Setting Prospective, population-based cohort study of a representative sample of residents (aged 20 to 79 years) of Pomerode, Santa Catarina, Brazil. Methods Data for the baseline survey (from 2014 to 2018) were collected through interviews and medical examinations, including socio-demographic and lifestyle information, clinical and subclinical conditions, oral and mental health, among others. Biosamples (blood, urine, stool, and saliva) were collected and stored. Methods of data collection and quality control are described. Preliminary descriptive statistics were performed. Results The response rate was 67.6% (n=2,488 individuals). The Kappa test-retest of some variables varied from 0.54 to 1.0. German culture participants are older (46.5 vs 38.7 years), self-declared white (97.3% vs 82.1%), more frequently never smokers (71.4% vs 66.9%) but had higher risk of consuming alcohol (16.9% vs 13.4%) compared to participants with non-German background. Germans were taller (169 cm vs 166 cm), had greater abdominal circumference among men (101.9 cm vs 97.3 cm). Furthermore, they reported more multimorbidity (56.7% vs 43.6%) , had more arterial hypertension (30.7% vs 18.5%), but less depression (15.4% vs 19,1%) than non-Germans. Conclusions The interaction of genetic and social/environmental issues should be examined to understand the role of risk factors on clinical conditions observed.

Introdução Poucos estudos compararam populações com histórico genético e cultural semelhante em diferentes continentes com métodos padronizados. Objetivos Descrever questões metodológicas do estudo de “Vida e Saúde em Pomerode - SHIP-Brazil” e algumas características dos participantes do exame inicial do estudo. Desenho de estudo e local Estudo de coorte prospectivo de base populacional em amostra representativa de moradores (20 a 79 anos) de Pomerode, Santa Catarina. Métodos As informações para a linha de base (de 2014 a 2018) foram coletadas por meio de entrevistas e exames médicos, incluindo dados sociodemográficos, de estilo de vida, condições clínicas e subclínicas, saúde bucal e mental, entre outros. Amostras biológicas (sangue, urina, fezes e saliva) foram coletadas e armazenadas. A coleta de dados e o controle de qualidade foram descritos. Foram realizadas análises descritivas preliminares. Resultados A taxa de resposta foi de 67,6% (n=2.488 indivíduos). O Kappa teste-reteste de algumas variáveis variou  de 0,54 a 1,0. Os participantes de cultura alemã são mais velhos (46,5 vs 38,7 anos ), autodeclarados brancos (97,3% vs 82,1%), com menor número de fumantes (71,4% vs 66,9%), mas tiveram maior risco de consumir álcool (16,9% vs 13,4%), eram mais altos (169 cm vs 166 cm), tinham maior circunferência abdominal entre os homens (101,9 cm vs 97,3 cm) em comparação com participantes “não-alemães”. Pessoas de cultura alemã relataram mais multimorbidade (56,7% vs 43,6%), apresentavam mais hipertensão arterial (30,7% vs 18,5%), mas menos depressão (15,4% vs 19,1%). Conclusões A interação genética e social/ambiental devem ser examinadas para melhor entender o papel desses fatores de risco nas condições clínicas observadas.

Abstract The objective of this work was to evaluate the mechanical performance of Z350 resin composite modified with Bombyx mori cocoons silk nanoparticles for dental applications. Four experimental groups were analyzed G0% = Filtek Z350 resin composite (control); G1% = Filtek Z350 with 1% of silk nanoparticles; G3% = Filtek Z350 with 3% of silk nanoparticles; G5% = Filtek Z350 with 5% of silk nanoparticles. It was employed scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction, 3-point flexural strength test, Knoop hardness test, and surface roughness. From 3-point flexural strength tests the control group presented the best results G0% = 113.33 MPa (±23.73). The higher flexural modulus was shown by groups G3% = 29.150 GPa (±5.191) and G5% = 34.101 GPa (±7.940), which are statistically similar. The Knoop microhardness test has shown statistical difference only among the G3% group between the top 80.78 (± 3.00) and bottom 68.80 (±3.62) and no difference between the groups. The roughness test presented no statistical difference between the groups. The incorporation of silk nanoparticles reduced the flexural strength of Z350 resin composite. The surface roughness and microhardness tests showed no changes in any of the groups studied. Z Z35 applications G0 G (control) G1 1 G3 3 G5 5 microscopy Xray X ray spectroscopy diffraction 3point point 11333 113 33 113.3 ±23.73. 2373 ±23.73 . 23 73 (±23.73) 29150 29 150 29.15 ±5.191 5191 191 (±5.191 34101 34 101 34.10 ±7.940, 7940 ±7.940 , 7 940 (±7.940) similar 8078 80 78 80.7 ± ( 3.00 300 00 6880 68 68.8 ±3.62 362 62 (±3.62 studied Z3 (control 1133 11 113. 237 ±23.7 2 (±23.73 2915 15 29.1 ±5.19 519 19 (±5.19 3410 10 34.1 794 ±7.94 94 (±7.940 807 8 80. 3.0 30 0 688 6 68. ±3.6 36 (±3.6 ±23. (±23.7 291 29. ±5.1 51 (±5.1 341 34. 79 ±7.9 9 (±7.94 3. ±3. (±3. ±23 (±23. ±5. (±5. ±7. (±7.9 ±3 (±3 ±2 (±23 ±5 (±5 ±7 (±7. (±2 (±7

Resumo O objetivo deste trabalho foi avaliar o desempenho mecânico da resina composta Z350 modificada com nanopartículas de seda Bombyx mori cocoons para aplicações odontológicas. Quatro grupos experimentais foram analisados: G0%) Resina Z350 apenas (grupo controle); G1%) Reforço com 1% de nanopartículas de seda; G3%) Reforço com 3% de nanopartículas de seda; e G5%) Reforço com 5% de nanopartículas de seda. Foi empregado microscopia eletrônica de varredura, espectroscopia de energia dispersiva de raios X, difração de raios X, teste de resistência à flexão de 3 pontos, teste de dureza Knoop e rugosidade superficial. Nos testes de resistência à flexão de 3 pontos o grupo controle apresentou melhores resultados G0% = 0.113 GPa (±0.024). O maior módulo de flexão foi demonstrado pelos grupos G3% = 29.151GPa (±5.191) e G5% = 34.102 GPa (±7.94), que são estatisticamente semelhantes. O teste de microdureza Knoop mostrou diferença estatística apenas entre o grupo G3% entre os 80.78 superiores (± 3.00) e os 68.80 inferiores (±3.62). Não há diferença entre os grupos. O teste de rugosidade não apresentou diferença estatística entre os grupos. A incorporação de nanopartículas de seda reduziu a resistência à flexão da resina composta Z350. Os testes de rugosidade superficial e microdureza não apresentaram alterações em nenhum dos grupos estudados. Z Z35 odontológicas analisados G0 G controle) G1% G1 1 G3 G5 5 varredura X 0113 0 113 0.11 ±0.024. 0024 ±0.024 . 024 (±0.024) 29151GPa 29 151GPa ±5.191 5191 191 (±5.191 34102 34 102 34.10 ±7.94, 794 ±7.94 , 7 94 (±7.94) semelhantes 8078 80 78 80.7 ± ( 3.00 300 00 6880 68 68.8 ±3.62. 362 ±3.62 62 (±3.62) estudados Z3 011 11 0.1 002 ±0.02 02 (±0.024 2 ±5.19 519 19 (±5.19 3410 10 34.1 79 ±7.9 9 (±7.94 807 8 80. 3.0 30 688 6 68. 36 ±3.6 (±3.62 01 0. ±0.0 (±0.02 ±5.1 51 (±5.1 341 34. ±7. (±7.9 3. ±3. (±3.6 ±0. (±0.0 ±5. (±5. ±7 (±7. ±3 (±3. ±0 (±0. ±5 (±5 (±7 (±3 (±0

Abstract Background The increase of hypertension in children and adolescents has attracted the attention of the scientific community largely due to its association with the obesity epidemic. Objectives To describe the incidence of hypertension and its relationship with the cardiometabolic and genetic profile in children and adolescents from a city in southern Brazil in a three-year period. Methods This longitudinal study followed 469 children and adolescents, aged 7-17 years old (43.1% boys), assessed at two-time points. We evaluated systolic and diastolic blood pressures (SBP and DBP), waist circumference (WC), body mass index (BMI), body fat percentage (%BF), lipid profile, glucose, cardiorespiratory fitness (CRF), and rs9939609 Polymorphism ( FTO ). Cumulative incidence of hypertension was calculated, and multinomial logistic regression was conducted. The statistical significance was established as p < 0.05. Results After three years, the incidence of hypertension was 11.5%. Overweight or obese individuals were more likely to become borderline hypertensive (overweight OR: 3.22, 95% CI: 1.08-9.55; obesity OR: 4.05, 95% CI: 1.68-9.75), and obese individuals were more likely to become hypertensive (obesity OR: 4.84, 95% CI: 1.57-14.95). High-risk WC and %BF values were associated with hypertension development (OR: 3.41, 95% CI: 1.26-9.19; OR: 2.49, 95% CI: 1.08-5.75, respectively). Conclusions We found a higher incidence of hypertension in children and adolescents as compared with previous studies. Individuals with higher values of BMI, WC and %BF at baseline were more likely to develop hypertension, suggesting the importance of adiposity in the development of hypertension even in such a young population. epidemic threeyear year period 46 717 7 17 7-1 43.1% 431 43 1 (43.1 boys, boys , boys) twotime two time points SBP DBP, DBP DBP) WC, (WC) BMI (BMI) %BF, BF (%BF) glucose CRF, CRF (CRF) rs rs993960 . ) calculated conducted 005 0 05 0.05 115 11 5 11.5% overweight OR 322 3 22 3.22 95 CI 1.089.55 108955 1.08 9.55 08 9 55 1.08-9.55 405 4 4.05 1.689.75, 168975 1.68 9.75 68 75 1.68-9.75) 484 84 4.84 1.5714.95. 1571495 1.57 14.95 57 14 1.57-14.95) Highrisk High risk (OR 341 41 3.41 1.269.19 126919 1.26 9.19 26 19 1.26-9.19 249 2 49 2.49 1.085.75, 108575 5.75, 1.08-5.75 respectively. respectively respectively) studies population 71 7- 43.1 (43. (WC (BMI (%BF (CRF rs99396 00 0.0 11.5 32 3.2 089 1.089.5 10895 108 1.0 955 9.5 1.08-9.5 40 4.0 689 1.689.75 16897 168 1.6 975 9.7 6 1.68-9.75 48 8 4.8 5714 1.5714.95 157149 157 1.5 1495 14.9 1.57-14.95 34 3.4 269 1.269.1 12691 126 1.2 919 9.1 1.26-9.1 24 2.4 085 1.085.75 10857 575 5.75 1.08-5.7 43. (43 rs9939 0. 11. 3. 1.089. 1089 10 1. 9. 1.08-9. 4. 1.689.7 1689 16 97 1.68-9.7 571 1.5714.9 15714 15 149 14. 1.57-14.9 1.269. 1269 12 91 1.26-9. 2. 1.085.7 1085 5.7 1.08-5. (4 rs993 1.089 1.08-9 1.689. 1.68-9. 1.5714. 1571 1.57-14. 1.269 1.26-9 1.085. 5. 1.08-5 rs99 1.08- 1.689 1.68-9 1.5714 1.57-14 1.26- 1.085 rs9 1.68- 1.571 1.57-1 1.57-

Resumo Fundamento O aumento de hipertensão em crianças e adolescentes tem atraído a atenção da comunidade científica, especialmente por sua associação com a epidemia da obesidade. Objetivos Descrever a incidência de hipertensão e sua relação com o perfil cardiometabólico e genético em crianças e adolescentes de uma cidade do sul do Brasil em um período de três anos. Métodos Este estudo longitudinal acompanhou 469 crianças e adolescentes com idade entre 7 e 17 anos (43,1% do sexo masculino), avaliados em dois momentos. Avaliamos pressão arterial sistólica (PAS), pressão arterial diastólica (PAD), circunferência da cintura (CC), índice de massa corporal (IMC), porcentagem de gordura corporal (%GC), perfil lipídico, glicemia, aptidão cardiorrespiratória (APCR), e polimorfismo rs9939609 (gene FTO ) ( fat mass and obesity - associated gene ). A incidência cumulativa da hipertensão foi calculada, e realizada regressão logística multinominal. A diferença estatística foi estabelecida em p<0,05. Resultados Após três anos, a incidência de hipertensão foi de 11,5%. Indivíduos com sobrepeso e indivíduos obesos apresentaram maior probabilidade de se tornarem indivíduos classificados como borderline para hipertensão (sobrepeso OR: 3,22; IC95%: 1,08-9,55; obesidade OR: 4,05; IC95%: 1,68-9,75), e indivíduos obesos apresentaram maior probabilidade de se tornarem hipertensos (obesidade OR: 4,84; IC95%: 1,57-14,95). Valores de CC e de %GC considerados de alto risco foram associados com o desenvolvimento de hipertensão (OR: 3,41; IC95%: 126-9,19; OR: 2,49, IC95%: 1,08-5,75, respectivamente). Conclusão Encontramos uma incidência de hipertensão em crianças e adolescentes mais alta em comparação a estudos anteriores. Indivíduos com valores mais altos de IMC, CC e %GC no baseline apresentaram maior probabilidade de desenvolverem hipertensão, sugerindo a importância da adiposidade no desenvolvimento de hipertensão, mesmo em uma população tão jovem. científica 46 1 43,1% 431 43 (43,1 masculino, masculino , masculino) momentos PAS, PAS (PAS) PAD, PAD (PAD) CC, (CC) IMC (IMC) %GC, GC (%GC) lipídico glicemia APCR, APCR (APCR) rs rs993960 . calculada multinominal p005 p 0 05 p<0,05 115 11 5 11,5% OR 3,22 322 3 22 IC95% IC95 IC 1,089,55 108955 1,08 9,55 08 9 55 1,08-9,55 4,05 405 4 1,689,75, 168975 1,68 9,75 68 75 1,68-9,75) 4,84 484 84 1,5714,95. 1571495 1,57 14,95 57 14 95 1,57-14,95) (OR 3,41 341 41 1269,19 126919 126 9,19 19 126-9,19 249 2 49 2,49 1,085,75, 108575 5,75, 1,08-5,75 respectivamente. respectivamente respectivamente) anteriores jovem 43,1 (43, (PAS (PAD (CC (IMC (%GC (APCR rs99396 p00 p<0,0 11,5 3,2 32 IC9 089 1,089,5 10895 108 1,0 955 9,5 1,08-9,5 4,0 40 689 1,689,75 16897 168 1,6 975 9,7 6 1,68-9,75 4,8 48 8 5714 1,5714,95 157149 157 1,5 1495 14,9 1,57-14,95 3,4 34 1269 1269,1 12691 12 919 9,1 126-9,1 24 2,4 085 1,085,75 10857 575 5,75 1,08-5,7 43, (43 rs9939 p0 p<0, 11, 3, 1,089, 1089 10 1, 9, 1,08-9, 4, 1,689,7 1689 16 97 1,68-9,7 571 1,5714,9 15714 15 149 14, 1,57-14,9 1269, 91 126-9, 2, 1,085,7 1085 5,7 1,08-5, (4 rs993 p<0 1,089 1,08-9 1,689, 1,68-9, 1,5714, 1571 1,57-14, 126-9 1,085, 5, 1,08-5 rs99 p< 1,08- 1,689 1,68-9 1,5714 1,57-14 126- 1,085 rs9 1,68- 1,571 1,57-1 1,57-

Abstract Background Major advances have been seen in techniques and devices for performing percutaneous coronary interventions (PCIs) for chronic total occlusions (CTOs), but there are limited real-world practice data from developing countries. Objectives To report clinical and angiographic characteristics, procedural aspects, and clinical outcomes of CTO PCI performed at dedicated centers in Brazil. Methods Included patients underwent CTO PCI at centers participating in the LATAM CTO Registry, a Latin American multicenter registry dedicated to prospective collection of these data. Inclusion criteria were procedures performed in Brazil, age 18 years or over, and presence of CTO with PCI attempt. CTO was defined as a 100% lesion in an epicardial coronary artery, known or estimated to have lasted at least 3 months. Results Data on 1196 CTO PCIs were included. Procedures were performed primarily for angina control (85%) and/or treatment of moderate/severe ischemia (24%). Technical success rate was 84%, being achieved with antegrade wire approaches in 81% of procedures, antegrade dissection and re-entry in 9%, and retrograde approaches in 10%. In-hospital adverse cardiovascular events occurred in 2.3% of cases, with a mortality rate of 0.75%. Conclusions CTOs can be treated effectively in Brazil by using PCI, with low complication rates. The scientific and technological development observed in this area in the past decade is reflected in the clinical practice of dedicated Brazilian centers. (PCIs CTOs, , (CTOs) realworld real world countries characteristics aspects Registry 1 over attempt 100 artery months 119 included 85% 85 (85% andor moderatesevere moderate severe 24%. 24 24% . (24%) 84 84% 81 reentry re entry 9 9% 10 10% Inhospital In hospital 23 2 2.3 cases 075 0 75 0.75% rates (CTOs 11 8 (85 (24% 2. 07 7 0.75 (8 (24 0.7 ( (2 0.

Resumo Fundamento Tem sido observado um grande avanço nas técnicas e nos dispositivos para a realização de intervenções coronárias percutâneas (ICP) em oclusões totais coronarianas crônicas (OTC), mas existem poucos dados da prática do mundo real em países em desenvolvimento. Objetivos Relatar as características clínicas e angiográficas, os aspectos dos procedimentos e os resultados clínicos da ICP de OTC em centros dedicados a esse procedimento no Brasil. Métodos Os pacientes incluídos foram submetidos à ICP de OTC em centros participantes do LATAM CTO Registry, um registro multicêntrico latino-americano dedicado à coleta prospectiva desses dados. Os critérios de inclusão foram procedimentos realizados no Brasil, idade acima de 18 anos e presença de OTC com tentativa de ICP. A definição de OTC foi lesão de 100% em uma artéria coronária epicárdica, conhecida ou estimada como tendo pelo menos 3 meses de evolução. Resultados Foram incluídos dados de 1.196 ICPs de OTC. Os procedimentos foram realizados principalmente para controle da angina (85%) e/ou tratamento de uma grande área isquêmica (24%). A taxa de sucesso técnico foi de 84% e foi alcançada com técnicas de fios anterógrados em 81%, dissecção/reentrada anterógrada em 9% e retrógrada em 10% dos procedimentos. Os eventos cardiovasculares adversos intra-hospitalares ocorreram em 2,3% dos casos, sendo a mortalidade de 0,75%. Conclusões As OTC podem ser tratadas no Brasil por intervenção coronária percutânea de forma efetiva e com baixas taxas de complicações. O desenvolvimento científico e tecnológico observado nessa área na última década reflete-se na prática clínica de centros brasileiros dedicados a essa técnica. (ICP OTC, , (OTC) angiográficas Registry latinoamericano latino americano 1 100 epicárdica evolução 1196 196 1.19 85% 85 (85% eou 24%. 24 24% . (24%) 84 81 81% dissecçãoreentrada dissecção reentrada 9 10 intrahospitalares intra hospitalares 23 2 2,3 casos 075 0 75 0,75% complicações refletese reflete se técnica (OTC 119 19 1.1 8 (85 (24% 2, 07 7 0,75 11 1. (8 (24 0,7 ( (2 0,

Abstract Chagas disease is a neglected parasitic disease caused by Trypanosoma cruzi, whose treatment has remained unsatisfactory for over 50 years, given that it is limited to two drugs. Benznidazole (BZN) is an efficient antichagasic drug used as the first choice, although its poor water-solubility, irregular oral absorption, low efficacy in the chronic phase, and various associated adverse effects are limiting factors for treatment. Incorporating drugs with such characteristics into nanostructured lipid carriers (NLC) is a promising alternative to overcome these limiting obstacles, enhancing drug efficacy and bioavailability while reducing toxicity. Therefore, this study proposed NLC-BZN formulations in different compositions prepared by hot-melt homogenization followed by ultrasound, and the optimized formulation was characterized by FTIR, DRX, DSC, and thermogravimetry. Biological activities included in vitro membrane toxicity (red blood cells), fibroblast cell cytotoxicity, and trypanocidal activity against epimastigotes of the Colombian strain of T. cruzi. The optimized NLC-BZN had a small size (110 nm), negative zeta potential (-18.0 mV), and high encapsulation (1.64% of drug loading), as shown by infrared spectroscopy, X-ray diffraction, and thermal analysis. The NLC-BZN also promoted lower in vitro membrane toxicity (<3% hemolysis), and 50% cytotoxic concentration (CC50) for NLC-BZN in L929 fibroblast cells (110.7 µg/mL) was twice the value as the free BZN (51.3 µg/mL). Our findings showed that the NLC-BZN had higher trypanocidal activity than free BZN against the epimastigotes of the resistant Colombian strain, and this novel NLC-BZN formulation proved to be a promising tool in treating Chagas disease and considered suitable for oral and parenteral administration. cruzi 5 years (BZN choice watersolubility, watersolubility water solubility, solubility water-solubility absorption phase NLC (NLC obstacles Therefore NLCBZN hotmelt hot melt ultrasound FTIR DRX DSC thermogravimetry red cells, , cells) cytotoxicity T 110 (11 nm, nm nm) 18.0 180 18 0 (-18. mV, mV mV) 1.64% 164 1 64 (1.64 loading, loading loading) spectroscopy Xray X ray diffraction analysis <3% 3 (<3 hemolysis, hemolysis hemolysis) CC50 CC (CC50 L L92 110.7 1107 7 (110. µg/mL µgmL µg mL 51.3 513 51 (51. µg/mL. . administration 11 (1 18. (-18 1.64 16 6 (1.6 <3 (< CC5 (CC5 L9 110. 51. (51 ( (-1 1.6 (1. < (CC (5 (- 1.

Abstract Alpinia zerumbet is a plant popularly used to treat hypertension and anxiety. Studies with Alpinia zerumbet demonstrate antihypertensive and vasodilator effects, among others. The objective of this study was to analyze the effect of essential oil of Alpinia zerumbet (EOAz) on cardiovascular and autonomic function in rats with isoproterenol-induced myocardial infarction. Male Wistar rats (n=32) were equally allocated into four groups: Control, ISO (150mg/kg, subcutaneous), EOAz (100mg/kg by gavage), ISO+EOAz. The rats were evaluated for cardiovascular and, autonomic parameters, electrocardiogram, and infarct size. EOAz was not able to reduce the electrocardiographic variations induced by ISO. Heart rate variability showed a decrease in sympathetic modulation on the heart in the groups treated with EOAz. The cardiopulmonary reflex induced by serotonin invoked a superior blood pressure variation at the 2 µg/kg dose in the EOAz treated groups, while the heart rate variation was significantly higher at the 16 µg/kg dose, when compared to other doses, in all groups, except EOAz+ISO. The sympathetic vagal index was higher in ISO group than in control. EOAz did not reduce the infarct size. We conclude that pretreatment with EOAz does not reverse the hemodynamic and electrocardiographic damage caused by isoproterenol but does reduce sympathetic modulation. anxiety effects others (EOAz isoproterenolinduced infarction n=32 n32 n 32 (n=32 Control 150mg/kg, 150mgkg mgkg 150mg kg mg (150mg/kg subcutaneous, subcutaneous , subcutaneous) 100mg/kg 100mgkg 100mg gavage, gavage gavage) ISOEOAz ISO+EOAz parameters electrocardiogram size µgkg µg 1 doses EOAzISO EOAz+ISO control n=3 n3 3 (n=3 150mg/kg n= (n= (n

ABSTRACT Objective: This study reflects on recent movements for book censorship and on acts of resistance both at home and abroad with a view to raise awareness in the librarian community not only to acts of censorship but also to necessary action to confront and resist them. Method: This is an exploratory study with a qualitative approach based on Michel Foucault's theoretical-methodological perspective. It focuses on statements found in reports on book and library-related censorship. The analyzed corpus consists of news articles from national and international media from the years 2020 through 2022. Result: Our survey presents cases of censorship from Kuwait, the United States, and Brazil. We noticed censorship both prior to a book launch as well as the banning of books already available in libraries, particularly school and public libraries, as demanded by a segment of the local community. In view of the accounts we gathered and reflected on, we list ten forms of resistance to the current censorship of books and other bibliographic productions. Conclusions: Despite constant attacks on freedom of expression and thought, such as on books one might wish to read, different acts of resistance and confrontation can be observed. Either by local communities that unite to protect libraries and the books therein, or by professionals and organizations linked to the librarian community that have been tireless in the fight for the preservation of rights. We highlight the importance of a free and independent press as a pillar of democracy as well as the need for unity and for a strengthening of the bonds between libraries, their communities, and the field of Library Science so that acts of censorship be denounced and fought against. Objective them Method Foucaults Foucault s theoreticalmethodological theoretical methodological perspective libraryrelated library related 202 2022 Result Kuwait States Brazil productions Conclusions thought read observed therein rights against 20 2

RESUMO Objetivo: Este texto tem como objetivo apresentar e refletir sobre os movimentos de censura aos livros nos últimos anos e as ações de resistências, nacionais e internacionais, com vistas a alertar a comunidade bibliotecária não apenas para as ações de censura, mas também de resistência e enfrentamento necessárias, sobretudo nos últimos anos. Método: Adotamos um estudo exploratório e de abordagem qualitativa, alicerçado na perspectiva teórico-metodológica de Michel Foucault, observando os enunciados de reportagens com a temática de censura relacionadas aos livros e às bibliotecas. O corpus de análise abrangeu notícias vinculadas na mídia nacional e internacional no período de 2020 a 2022. Resultado: Com o levantamento, apresentamos os casos de censuras que ocorreram no Kuwait, Estados Unidos e Brasil. Observamos a existência tanto de censura prévia aos livros quanto de ações que envolvem a retirada de obras já disponíveis em bibliotecas, em especial, escolares e públicas, por exigência de parte de suas comunidades. Diante do que compilamos e refletimos, listamos dez formas de resistência à censura aos livros e às demais produções bibliográficas na atualidade. Conclusões: Apesar de constantes ataques à liberdade de expressão e de pensamento, como ao livro que se deseja ler, diferentes ações de resistência e enfrentamentos podem ser vistas, seja por meio das comunidades locais que se unem para proteger as obras e as bibliotecas, seja de profissionais e organizações ligadas à comunidade bibliotecária que tem sido incansáveis na luta e na preservação de direitos. Ressaltamos a importância da imprensa livre e independente como pilar da democracia e a necessidade de união e fortalecimento dos vínculos entre bibliotecas, suas comunidades e a área da Biblioteconomia para que ações de censura sejam denunciadas e combatidas. Objetivo resistências internacionais necessárias Método qualitativa teóricometodológica teórico metodológica Foucault bibliotecas 202 2022 Resultado levantamento Kuwait Brasil especial públicas refletimos atualidade Conclusões pensamento ler direitos combatidas 20 2

Carboxymethyl cellulose (CMC) is considered a non-toxic, biodegradable and biocompatible polymer. CMC-based films are rated as flexible, clear, odorless, moderately tear resistant, resistant to oil and grease migration, and water soluble. Due to its hydrophilicity, CMC can serve as matrix to encapsulate hydrophobic substances, like essential oils, by emulsion dispersions. The essential oil of rue (Ruta graveolens) has antifungal, antimicrobial, insecticide and therapeutic properties already reported in the literature. For the incorporation of rue essential oil in the CMC films, the ultrasound-assisted emulsion technique was used. The films were produced by casting evaporation. The rue essential oil emulsion and CMC polymeric films with the incorporation of emulsified essential oil were evaluated according to the emulsion droplet size, chemical composition, morphology and thermogravimetric profile. The droplet size obtained for the emulsion was 229.1 nm. The films showed good transparency, regularity and chemical characteristics similar to those of the pure polymer. (CMC nontoxic, nontoxic non toxic, toxic non-toxic polymer CMCbased based flexible clear odorless migration soluble hydrophilicity substances oils dispersions Ruta graveolens antifungal antimicrobial literature ultrasoundassisted ultrasound assisted used evaporation composition profile 2291 229 1 229. nm transparency 22 2

Resumo Este artigo analisa a qualidade de legendas interlinguais traduzidas automaticamente e pós-editadas no par linguístico EN/PT-BR. A análise aplicou o FAR model, um Modelo de Avaliação da Qualidade de Tradução, às legendas em PT-BR do trailer do filme The Red Sea Diving Resort, no Brasil: Missão no Mar Vermelho, correlacionando-o com dados empíricos coletados com tradutores (avaliação da qualidade) e com a audiência (recepção). Os dados de recepção foram coletados com alunos da graduação, que foram divididos em dois grupos: o grupo controle, que assistiu ao trailer com as legendas disponibilizadas pela Netflix; e o grupo experimental, que assistiu ao trailer com as legendas pós-editadas. Os dados de avaliação da qualidade foram coletados com tradutores que assistiram ao trailer com as legendas pós-editadas. Os instrumentos de coleta foram uma escala Likert de 5 pontos, um questionário e protocolos verbais guiados. Os dados coletados com os participantes foram correlacionados com as categorizações de erros do FAR model (Equivalência Funcional, Aceitabilidade e Leiturabilidade). Os resultados indicaram que as legendas pós-editadas possuem qualidade boa em termos de significado e normas da língua-alvo; entretanto, os parâmetros técnicos tiveram qualidade inferior, o que afetou a apreciação do trailer conforme relatado pela maioria da audiência. Devido à amostra reduzida, são necessários estudos empíricos adicionais para a obtenção de padrões mais sólidos de avaliação da qualidade de legendas pós-editadas.

Abstract This paper analyzes the quality of machine-translated interlingual subtitles, which were post-edited in the language pair EN/PT-BR. Our analyses applied the FAR model, a Translation Quality Assessment Model, to the PT-BR subtitles of The Red Sea Diving Resort movie trailer, correlating it to empirical data collected with translators (quality assessment) and audience (reception). Reception data was collected with undergraduate students, which were divided into two groups: the control group that watched the subtitled trailer available on Netflix; and the experimental group that watched the trailer with post-edited subtitles. Quality data was collected with translators and they watched the trailer with post-edited subtitles. We used a 5-point Likert-type scale, a questionnaire and a guided think-aloud protocol to collect our data. Data collected with both translators and students were correlated with the FAR model error scores (Functional Equivalence, Acceptability and Readability). Our results indicate that the post-edited subtitles had good quality in terms of meaning and target language norms; however, the technical parameters had lower quality, which affected the trailer appreciation as reported by most of the audience. Due to the small sample size, further empirical studies are required to obtain solid standards for assessing the quality of post-edited subtitles.

Abstract Background Hypertension is an increasingly common problem in adolescents; amongst the associated factors, physical inactivity and obesity are increasing the risk of developing cardiovascular diseases. Objective To verify whether there is an association between higher blood pressure levels amongst adolescents with the relationship between different levels of body mass index (BMI) and cardiorespiratory fitness (CRF). Method Cross-sectional study consisting of 860 adolescents. Higher blood pressure (BP) was considered as borderline and hypertension as the classification. BMI was categorized as low-normal weight and overweight-obesity. The CRF was assessed by a nine-minute run/walk test and classified into low or appropriate levels (less and more favorable to health, respectively). Later, BMI and CRF were grouped into one categorical variable: (I) low/normal weight and appropriate CRF levels; (II) low/normal weight and low CRF levels; (III) overweight/obesity and appropriate CRF levels; and (IV) overweight/obesity and low CRF levels. Data were analyzed using Poisson regression, through the prevalence ratio (PR) and 95% confidence intervals (CI). The p-values of p <0.05 were considered significant. Results Adolescents with overweight/obesity and low CRF levels had a 22% higher BP prevalence. Moreover, children with overweight/obesity, but with appropriate CRF levels, have a 15% higher BP prevalence. Conclusion Adolescents with overweight/obesity had a higher prevalence of BP, regardless of CRF levels. It is suggested that maintaining normal BMI is a protective factor for less favorable BP. factors diseases (BMI CRF. . (CRF) Crosssectional Cross sectional 86 (BP classification lownormal overweightobesity. overweightobesity overweight obesity. overweight-obesity nineminute nine minute runwalk run walk health respectively. respectively respectively) Later variable I (I II (II III (III IV (IV regression PR (PR 95 CI. CI (CI) pvalues values 005 0 05 <0.0 significant 22 Moreover 15 (CRF 8 9 (CI 00 <0. 2 1 <0 <

Resumo Objetivos: Avaliar a eficácia do branqueamento dentário de técnica in-office paint-on com peróxido de hidrogénio a 6% com dois tipos diferentes de materiais de isolamento relativo. Métodos: Vinte pacientes foram selecionados de acordo com os critérios de inclusão e exclusão, submetidos a profilaxia dentária profissional e alocados aleatoriamente num de dois grupos. Foi realizado o protocolo de técnica de branqueamento in-office (VivaStyle Paint On PIus, lvoclar-Vivadent®, Liechtenstein) com dois materiais de isolamento relativo: Grupo 1 - Vaselina; Grupo 2 - resina block-out. A eficácia de branqueamento foi avaliada com ΔE00 e ΔWID, calculados a partir dos valores CIE L*a*b* obtidos por análise espectrofotométrica (SpectroShade). Testes estatísticos apropriados foram realizados para analisar diferenças intragrupo nos valores CIE L*a*b* e WID e diferenças intergrupo em ΔE00 e ΔWID com α=0,05. Resultados: Ambos os grupos apresentaram diferenças estatisticamente significativas (P<0,01) no CIE L*a*b* e WID. Tanto ΔE00 quanto ΔWID ultrapassaram o limite de aceitabilidade (ΔE00 >1,8; ΔWID > 2,60). O Grupo 2 apresentou valores médios estatisticamente significantes superiores (P<0,01) com ΔE00 = 3,5 ± 1,5 e ΔWID = 8,6 ± 4,2. Conclusões: A técnica de branqueamento dentário in-office do tipo paint-on a 6% peróxido de hidrogénio apresentou eficácia clínica, porém dependente do material de isolamento, com melhores resultados na aplicação de resina block-out, sugerindo a sua recomendação clínica.

Abstract Objectives: To evaluate the tooth bleaching effectiveness of a 6% hydrogen peroxide paint-on varnish with two different types of soft-tissue protection materials. Methods: Twenty patients were screened according to inclusion and exclusion criteria, submitted to professional dental prophylaxis, and randomly allocated to one of the two groups. An in-office bleaching technique protocol was performed (VivaStyle Paint On PIus, lvoclar-Vivadent®, Liechtenstein) with two different soft-tissue protection materials: Group 1 - Vaseline; Group 2 - block-out resin. Bleaching effectiveness was evaluated with ΔE00 and ΔWID, calculated from the CIE L*a*b* values obtained by spectrophotometry analysis (SpectroShade). Appropriate statistical tests were performed to analyze intragroup differences in CIE L*a*b* and WID values and intergroup differences in ΔE00 and ΔWID with α=0.05. Results: Both groups presented statistically significant (P<0.01) differences in CIE L*a*b* and WID. Both ΔE00 and ΔWID surpassed the acceptability threshold (ΔE00 > 1.8; ΔWID > 2.60), and the ΔWID was mostly classified as hardly acceptable differences. Group 2 presented higher statistically significant (P<0.01) mean values with ΔE00 = 3.5 ± 1.5 and ΔWID = 8.6 ± 4.2. Conclusions: The 6% hydrogen peroxide paint-on varnish tooth bleaching technique showed clinical effectiveness. However, effectiveness varied with the soft-tissue protection material used, with better results when applying a block-out resin, thus suggesting its clinical recommendation.

Resumo O objetivo deste trabalho foi avaliar os efeitos dos tratamentos em pós-floração (PF) ou pré-colheita (PC) de macieiras ‘Braeburn’ com prohexadiona-cálcio (ProCa; 300 mg L-1), um inibidor da biossíntese de giberelinas, ou GA4+7 (300 mg L-1), na qualidade dos frutos na colheita e após o armazenamento (quatro meses a 0±0,5 oC, seguido por cinco dias de vida de prateleira). Os tratamentos PF começaram 15 dias após a plena floração, com uma aplicação a cada semana e seis aplicações no total. Os tratamentos PC começaram cinco semanas antes da previsão de colheita comercial, com uma aplicação por semana e quatro aplicações no total. Plantas controle foram pulverizadas com água. GA4+7 pulverizado em PF aumentou a relação comprimento/diâmetro, e GA4+7 pulverizado em PC aumentou a acidez titulável (AT) e a firmeza de polpa, e causou leve redução na cor vermelha dos frutos na colheita. ProCa, pulverizado em PF e PC, reduziu a taxa de produção de etileno, o índice de iodo-amido e o teor de sólidos solúveis dos frutos na colheita, e ProCa pulverizado em PC aumentou a firmeza de polpa na colheita e após o armazenamento, e a AT dos frutos após o armazenamento. ProCa, pulverizado em PF e PC, retardou a perda da cor de fundo (verde) e o aumento na cor vermelha dos frutos na colheita, porém com maior efeito ao ser pulverizado em PC do que em PF.

Abstract The objective of this study was to assess the effects of post-bloom (PB) or preharvest (PH) treatments of ‘Braeburn’ apple trees with prohexadione-calcium (ProCa; 300 mg L-1), an inhibitor of gibberellins biosynthesis, or GA4+7 (300 mg L-1) on fruit quality at harvest and after storage (four months at 0±0.5 oC, followed by five days of shelf life). PB treatments started 15 days after full bloom, with one application every week and six applications in total. PH treatments started five weeks before anticipated harvest, with one application every week and four applications in total. Control trees were sprayed with water. GA4+7 PB increased length/diameter ratio, and GA4+7 PH increased titratable acidity (TA) and flesh firmness and slightly reduced red color of the fruit at harvest. ProCa PB and PH reduced ethylene production rate, delayed starch degradation and reduced soluble solids content of the fruit at harvest, and ProCa PH maintained firmness at harvest and after storage and TA of the fruit after storage. ProCa PB or PH delayed the loss of skin green background color at harvest, while at both treatment timings reduced the development of skin red color, but with a much stronger effect when sprayed PH than PB.

RESUMO Objetivo Avaliar a reprodutibilidade, validade relativa, usando questionário de recordatório de 24 horas como padrão de referência, e estimar fatores de calibração de um questionário de frequência alimentar adaptado para uso com descendentes alemães vivendo no Brasil. Métodos A população alvo foi constituída de 50 voluntários, de ambos os sexos, com idade superior a 20 anos, residentes em uma cidade de colonização alemã do Sul do Brasil. O questionário de frequência alimentar foi aplicado duas vezes, no primeiro e terceiro mês. Neste período, foram aplicados três recordatórios de 24 horas, com intervalo de um mês entre eles. A Reprodutibilidade foi estimada pelo coeficiente de correlação intraclasse. Validade foi testada pelo coeficiente de correlação intraclasse, teste kappa ponderado e método Bland-Altman. Fatores de calibração foram estimados por meio de regressão linear. Resultados Entre os questionários de frequência alimentar, houve forte correlação para energia e a maioria dos nutrientes corrigidos para energia. Verificou-se fraca correlação entre questionário de frequência alimentar e recordatório de 24 horas. Porém, a concordância exata na categorização em tercis entre os instrumentos variou de 28% (vitamina A) a 52% (fibra e potássio). Valores brutos do questionário de frequência alimentar foram reduzidoscom a calibração e se aproximaram dos dados de consumo estimados pelo recordatório de 24 horas. Conclusão O questionário de frequência alimentar demonstrou boa reprodutibilidade, porém, fraca correlação com o recordatório de 24 horas. A calibração dos dados obtidos pelo questionário de frequência alimentar aproximou-os do método de referência.

ABSTRACT Objective This study evaluated reproducibility, relative validity, using a 24-hour recall questionnaire as a reference standard, and estimated calibration factors for a food frequency questionnaire adapted for use with German descendants living in Brazil. Methods The target population consisted of 50 volunteers, of both genders, aged over 20 years, living in a German colonization city in southern Brazil. The food frequency questionnaire was applied twice, in the first and third months of the investigation. During this period, three 24-hour recalls were applied, with an interval of one month between them. Reproducibility was estimated by the intraclass correlation coefficient. Validity was tested by the intraclass correlation coefficient, weighted kappa test and Bland-Altman method. Calibration factors were estimated using linear regression. Results Among the food frequency questionnaires, there was a strong correlation for energy and most of the nutrients corrected for energy. There was a weak correlation between a food frequency questionnaire and a 24-hour dietary recall. However, the exact concordance in the categorization in tertiles among the instruments ranged from 28% (vitamin A) to 52% (fiber and potassium). Gross values of the food frequency questionnaire were reduced with the calibration and approached the consumption data estimated by the 24-hour dietary recall. Conclusions The food frequency questionnaire showed good reproducibility, however, weak correlation with the 24-hour dietary recall. The calibration of the data obtained by the food frequency questionnaire brought them closer to the reference method.