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Abstract Background Hand osteoarthritis (HOA) is a highly prevalent disease that may be impacted by social inequalities. Few studies in HOA are from underdeveloped regions. We intend to contribute to fill this gap presenting clinical characteristics of our low-income HOA cohort (LIHOA). Methods Data from 119 patients with a HOA diagnosis fulfilling ACR criteria seen between August 2019 and May 2023 in Fortaleza/Brazil. Evaluations included pain (VAS, visual analogue scale), X-ray (KL, Kellgren-Lawrence), grip and pinch strength (KgF), Cochin hand functional scale (CHFS), FIHOA, and SF-12 scores. Social data included monthly (<1, 1≥/<3, ≥3 MW) minimum wage earnings, occupation, and literacy [</≥ 9 school-years (SY)]. Results 107 out of the 119 patients were included. Mean age was 61.9 (±10.3) years with 94 (92%) women. Systemic arterial hypertension (48%), metabolic syndrome (42.8%), dyslipidemia (28.4%), and obesity (25%) were the most common comorbidities. Mean disease duration was 7.5 ± 7.1 years. Median VAS values at rest and activity were 3 (3–5) and 8 (5–9), respectively (p < 0.001). Fifty-seven (56.4%) patients had ≥4 symptomatic joints with a median of 4 (2–8) painful joints at activity. The 2nd distal interphalangeal (IF), joint was the most symptomatic (21; 23.3%) and most had >4 IF nodes. OA in other joints: 37 (36.2%) spine, 28 (29.4%) knee, 21 (20.5%) bunions. Functional impairment was mild [8 (5–14) median FIHOA]. Median serum CRP was 0.2 mg/dL (0.1–0.4) with 14 (20%) patients above reference value. Mean total KL score was 27.6 ± 13.6 with 21 (23%), 38 (41.7%), and 33 (36.2%) KL2, KL3, and KL4, respectively; 51 (54.8%) and 42 (45.2%) patients declared </≥3 MW earnings, respectively. Most declared >9SY including 37.2% with a university degree. Individuals earning <3 MW had lower pinch (p < 0.004) and grip strength (p < 0.01), and higher FIHOA scores (p < 0.007), as compared to ≥3 MW earning group. Literacy or occupation did not impact outcome. SYSADOA were used by 13 (12.7%), 6 used oral and 3 topical anti-inflammatory drugs and 2 used 5 mg/d prednisone. Conclusion Clinical characteristics in our LIHOA cohort mirror those reported in affluent regions. Socioeconomic disparities influenced functional outcome in LIHOA cohort. (HOA inequalities regions lowincome low income LIHOA. . (LIHOA) 11 201 202 FortalezaBrazil Fortaleza Brazil Fortaleza/Brazil VAS, (VAS scale, , scale) Xray X ray KL, (KL KellgrenLawrence, KellgrenLawrence Kellgren Lawrence Kellgren-Lawrence) KgF, KgF (KgF) CHFS, CHFS (CHFS) SF12 SF 12 SF-1 <1, 1 (<1 1≥/<3 ≥ earnings </≥ [</ schoolyears school SY. SY (SY)] 10 619 61 61. ±10.3 103 (±10.3 92% 92 (92% women 48%, 48 48% (48%) 42.8%, 428 42.8% (42.8%) 28.4%, 284 28.4% (28.4%) 25% 25 (25% comorbidities 75 7 7. 71 3–5 35 (3–5 5–9, 59 5–9 (5–9) p 0.001. 0001 0.001 0 001 0.001) Fiftyseven Fifty seven 56.4% 564 56 (56.4% 2–8 (2–8 nd IF, (IF) (21 23.3% 233 23 > nodes 36.2% 362 36 (36.2% spine 29.4% 294 29 (29.4% knee 20.5% 205 20 (20.5% bunions [ 5–14 514 (5–14 FIHOA. FIHOA] 02 0. mgdL mg dL 0.1–0.4 0104 (0.1–0.4 20% (20% value 276 27 27. 136 13. 23%, 23% (23%) 41.7%, 417 41.7% 41 (41.7%) KL2 KL3 KL4 54.8% 548 54 (54.8% 45.2% 452 45 (45.2% 9SY 372 37.2 degree 0.004 0004 004 0.01, 0.01 01 0.01) 0.007, 0007 0.007 007 0.007) group 12.7%, 127 12.7% (12.7%) antiinflammatory anti inflammatory mgd d prednisone (LIHOA Kellgren-Lawrence (KgF (CHFS SF1 SF- <1 (< 1≥/< </ [< (SY) ±10. (±10. (92 (48% 42.8 (42.8% 28.4 (28.4% (25 3– (3– 5– (5–9 000 0.00 00 56.4 (56.4 2– (2– (IF (2 23.3 36.2 (36.2 29.4 (29.4 20.5 (20.5 5–1 (5–1 0.1–0. 010 (0.1–0. (20 (23% 41.7 (41.7% 54.8 (54.8 45.2 (45.2 37. 0.0 12.7 (12.7% ( 1≥/ (SY ±10 (±10 (9 (48 42. (42.8 28. (28.4 (3 (5– 56. (56. 23. 36. (36. 29. (29. 20. (20. 0.1–0 (0.1–0 (23 41. (41.7 54. (54. 45. (45. 12. (12.7 1≥ ±1 (±1 (4 (42. (28. (5 (56 (36 (29 0.1– (0.1– (41. (54 (45 (12. (± (42 (28 0.1 (0.1 (41 (12 (0. (1 (0