Summary Objective: To identify instruments for evaluation of peripheral neuropathy induced by chemotherapy that can be translated or adapted to monitor this adverse drug reaction in patients with multiple myeloma. Method: Narrative review, conducted between July 2018 and may 2019. Articles published in English and Portuguese were eligible between June2007 and January 2019, available in full in a free manner or in periodicals of the CAPES Coordination Portal for Improvement of Level Personnel Higher. Animal studies, monographs, guidelines, theses, clinical cases and non-health studies were excluded. Results: Five instruments were identified:Patient Neurotoxicity Questionnaire;Funcional Assessment of Cancer Therapy/Gynecologyc Group – Neurotoxicity;Chemotherapy-Induced Peripheral NeuropathyAssessment Tool; Funcional AssessmentCancer Therapy/Taxane; Indicationfor Common Toxicity Criteria – Grading ofPeripheral Neuropathy Questionnaire (ICPNQ). After analyzing each tool presented,the ICPNQ proved to be valid andapplicable in clinical practice, however, itis in the English language. Conclusion: The translation and validation of the ICPNQ instrument into Portuguese would allow its incorporation into clinical practice in the monitoring of peripheral neuropathy induced by chemotherapy in patients with multiple myeloma.

Resumo Objetivo: Identificar instrumentos de avaliação da neuropatia periférica induzida por quimioterapia que possam ser traduzidos ou adaptados para monitoramento dessa reação adversa a medicamentos em pacientes com mieloma múltiplo. Método: Revisão narrativa, realizada entre julho de 2018 a maio de 2019. Foram elegíveis artigos publicados em inglês e português, entre junho de 2007 a janeiro de 2019, disponíveis na íntegra de maneira livre ou em periódicos do Portal da CAPES Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Foram excluídos estudos com animais, monografias, guidelines, teses, casos clínicos e estudos que não da área de saúde. Resultados: Foram identificados cinco instrumentos: Patient Neurotoxicity Questionnaire; Funcional Assessment of Cancer Therapy/ Gynecologyc Group – Neurotoxicity; Chemotherapy-Induced Peripheral Neuropathy Assessment Tool; Funcional Assessment Cancer Therapy/Taxane; Indication for Common Toxicity Criteria – Grading of Peripheral Neuropathy Questionnaire (ICPNQ). Após análise de cada ferramenta apresentada, o ICPNQ se mostrou válido e aplicável na prática clínica, porém, encontra-se em língua inglesa. Conclusão: A tradução e validação do instrumento ICPNQpara o português, possibilitaria sua incorporação à práticaclínica no monitoramento da neuropatia periférica induzidapor quimioterapia em pacientes com Mieloma Múltiplo.

ABSTRACT Feed formulation using linear programming consists of determining the mixture of feedstuffs required to meet pre-established animal nutritional requirements at the lowest cost. On the other hand, with the use of non-linear programming, it is possible to define nutritional requirements at the time of formulation, aiming at maximum profit. The objective of the present study was to compare feeds formulated using linear and non-linear programming in terms of live performance and internal and external egg quality of commercial laying hens. A total of 288 Hisex® White laying hens, 1.540 ± 0.128 g body weight, were evaluated from 33 to 45 weeks of age. Hens were distributed in a completely randomized block design, including six treatments with six replicates of eight birds each. Three treatments consisted of feeds formulated using linear programming and based on the nutritional requirements of Rostagno et al. (2011), of the genetic strain manual, or mathematical models to maximize performance. The other three treatments consisted of feeds formulated using non-linear programming considering typical, favorable, or unfavorable market scenarios. Data were submitted to analysis of variance, and in case of significance (p<0.05), means were grouped using the Scott-Knott test (5%).The treatments did not influence (p>0.05) Haugh unit, albumen height, or external egg quality parameters. Treatment effects (p<0.05) on yolk weight, albumen weight, yolk color, yolk percentage, albumen percentage, and performance parameters were described. In general, feeds formulated using linear programming and based on nutritional requirements obtained by mathematical models and the genetic strain manual promoted better performance results because the feeds were nutritionally denser. However, the treatments that maximized live performance did not result in higher profitability, which was obtained with the diet formulated for a favorable market scenario using non-linear programming.

ABSTRACT The objective of this study was to evaluate the effects of dietary nutrient levels on performance, carcass yield, commercial cuts, digestibility and economical viability of broilers from 1 to 42 days of age. During the experiment, 180 COBB 500™ chicks were housed in metal batteries and subjected to a completely randomized design in a 2x3 factorial arrangement, of two sexes and three diets (male, female and mixed), totaling 6 treatments and 6 repetitions of 5 birds each. Data were subjected to statistical analysis and the means were compared using the Tukey test, at 5% probability. The results indicate the effect of sex on performance and commercial cuts, except for breast and thigh fillets, in which males and females showed similar results when given the mixed diet. The influence of the nutritional levels on performance, digestibility and commercial cuts was observed, in which the female diet showed the highest results for feed intake, body weight and weight gain, in addition to greater retention of protein and crude energy. For drumstick and abdominal fat yield, the highest values were obtained using the mixed diet and the female diet, and the lowest values were obtained using the male diet. Regarding economic viability, the female diet showed the highest return per unit of Real (R$) spent on feed. Therefore, these data prove that the female diet had a positive effect when provided to both sexes, and it may be a promising alternative for its application at the production level.

RESUMO: No presente trabalho, o objetivo foi adequar a metodologia do teste de envelhecimento acelerado para avaliação do potencial fisiológico de sementes de Coriandrum sativum L. Seis lotes de sementes foram utilizados, sendo submetidos aos testes de germinação, índice de velocidade de emergência, emergência de plântulas e envelhecimento acelerado, empregando-se os períodos de envelhecimento de 24, 48, 72 e 96 horas, na metodologia tradicional com água e com o uso de solução saturada e não saturada de cloreto de sódio (NaCl). O teste de envelhecimento acelerado, utilizando solução salina saturada na combinação 24 horas a 41ºC é adequado para avaliação do potencial fisiológico de sementes de coentro. O período de 48 horas para o método de envelhecimento acelerado, utilizando solução salina saturada ou não, também é eficaz na avaliação do vigor em sementes de coentro.

ABSTRACT: This study aimed to adapt the methodology of the accelerated aging test to assess the physiological seed of Coriandrum sativum L. Six batches of seeds were tested for germination, emergence rate index, seedling emergence and accelerated aging employing the aging periods of 24, 48, 72 and 96 hours, the traditional methodology with water and the use of unsaturated and saturated sodium chloride (NaCl) solutions. Accelerated aging test using saturated saline 24 hours in a combination with 41ºC, is adequate to evaluate the physiological potential of coriander seeds. The period of 48 hour for accelerated aging method using saturated saline or not, is also effective in the evaluation vigor test of coriander seeds.

Neste estudo analisamos a composição da dieta e a amplitude e sobreposição do nicho trófico dos anuros de folhiço Ischnocnema henselii e Adenomera marmorata. Os anuros foram coletados em uma área de Mata Atlântica na Reserva Natural Salto Morato, no Estado do Paraná, Sul do Brasil, utilizando o método de parcelas de 16 m2 estabelecidas no chão da floresta. Ischnocnema henselii consumiu 18 diferentes tipos de presa e a dieta desta espécie foi composta predominantemente por Hymenoptera (Formicidae) (15,4%), Araneae (13,83%), Orthoptera (6,15%) e Opiliones (6,15%), enquanto Adenomera marmorata consumiu 15 diferentes tipos de presas e sua dieta foi composta principalmente por Hymenoptera (Formicidae) (45,7%), Acari (31,8%) e Blattodea (14,8%). A amplitude de nicho de I. henselii foi BA = 0,43 e de A.marmorata foi BA = 0,19. A dieta das duas espécies de anuros simpátricos do folhiço por nós estudadas foi composta basicamente de artrópodes e a sobreposição de nicho trófico entre elas não diferiu do esperado para ocorrer ao acaso. As diferenças no consumo de presas potencialmente devem facilitar a coexistência desses dois anuros simpátricos no chão da floresta. Possivelmente, esta diferença no consumo de presas em parte reflete diferenças na largura da mandíbula, no tamanho do corpo e no período de atividade dessas duas espécies.

In this study we analyzed diet composition, niche breadth and overlap of the two leaf-litter frogs Ischnocnema henselii and Adenomera marmorata. Frogs were collected in an Atlantic Rainforest area in the Reserva Natural Salto Morato, in Paraná State, Southern Brazil, using plots of 16 m2 established on forest floor. Ischnocnema henselii consumed 18 different types of prey and the diet of this species was composed predominantly by Hymenoptera (Formicidae) (15.4%), Araneae (13.83%), Orthoptera (6.15%) and Opiliones (6.15%), whereas Adenomera marmorata consumed 15 different types of prey and its diet was composed mainly by Hymenoptera (Formicidae) (45.7%), Acari (31.8%) and Blattodea (14.8%). The niche breadth of I. henselii was BA = 0.43 and that of A. marmorata was BA = 0.19. The diet of the two sympatric species of leaf-litter frogs was basically composed by arthropods and the trophic niche overlap among them did not differ from expected at random. The differences in prey consumption should potentially facilitate the coexistence of two sympatric frogs on the forest floor. Possibly, this difference of prey consumption partly reflects differences in jaw width, species-specific body size of the two species and the period of activity of these two species.