SUMMARY OBJECTIVE: Diabetes mellitus, per se, is a global health concern, which is often accompanied by complications such as diabetic neuropathy. This prospective observational study purposed to assess the durations of spinal sensory block and motor blocks in individuals with and without diabetes mellitus who had undergone spinal anesthesia. METHODS: This study incorporated 80 cases, which were evenly divided into spinal sensory block without diabetes mellitus and spinal sensory block with diabetes mellitus. Various parameters were recorded at different time points, including heart rate, mean arterial blood pressure, SpO2, and spinal block characteristics. Notable measures included maximum spinal sensory block onset time, time to reach the 10th thoracic vertebra (T10), maximal spinal sensory block, time for Bromage scores, and block regression while controlling for age-related variations. RESULTS: Patients in the diabetic group exhibited extended block durations, with significant differences in heart rate noted at specific time points. Regarding the spinal block characteristics, the “maximum onset of SSB” and the “time to reach the T10” were more prolonged in the SSBwDM without significance. Maximum sensory spinal sensory block did not differ. However, some cases in the SSBwDM displayed blocks extending up to the T6. The times to achieve Bromage motor block scores 1–3 were shorter in SSBwDM and lost significance regarding age. Notably, the regression time was longer in SSBwDM, which held significance for both parameters. CONCLUSION: Diabetic cases commonly encounter prolonged block durations post-subarachnoid intervention, potentially linked to nerve sensitivity, age-related changes, and glycemic control. As such, attenuated local doses for diabetic neuropathic cases may enhance early mobilization, attenuate thromboembolic events, and expedite gastrointestinal recovery. OBJECTIVE se concern neuropathy anesthesia METHODS 8 points pressure SpO2 SpO characteristics th T10, T10 T , (T10) agerelated age related variations RESULTS SSB differ However T6 13 1 3 1– Notably CONCLUSION postsubarachnoid post subarachnoid intervention sensitivity changes control mobilization events recovery T1 (T10 (T1 (T

SUMMARY OBJECTIVE: Erector spinae plane block is an updated method than paravertebral block, possessing a lower risk of complications. This study aimed to compare erector spinae plane and paravertebral blocks to safely reach the most efficacious analgesia procedure in laparoscopic cholecystectomy cases. METHODS: The study included 90 cases, aged 18–70 years, classified as American Society of Anesthesiologists I–II, who underwent an laparoscopic cholecystectomy procedure. They were randomly separated into three groups, namely, Control, erector spinae plane, and paravertebral block. No block procedure was applied to Control, and a patient-controlled analgesia device was prepared containing tramadol at a 10 mg bolus dose and a 10-min locked period. The pain scores were recorded with a visual analog scale for 24 h postoperatively. RESULTS: The visual analog scale values at 1, 5, 10, 20, and 60 min at rest and 60 min coughing were found to be significantly higher in Control than in paravertebral block. A significant difference was revealed between Control vs. paravertebral block and paravertebral block vs. erector spinae plane in terms of total tramadol consumption (p=0.006). Total tramadol consumption in the first postoperative 24 h was significantly reduced in the paravertebral block compared with the Control and erector spinae plane groups. CONCLUSION: Sonography-guided-paravertebral block provides sufficient postoperative analgesia in laparoscopic cholecystectomy surgery. Erector spinae plane seems to attenuate total tramadol consumption. OBJECTIVE complications cases METHODS 9 1870 18 70 18–7 years III I II I–II groups namely patientcontrolled patient controlled 1 10min period 2 postoperatively RESULTS 5 20 6 vs p=0.006. p0006 p p=0.006 . 0 006 (p=0.006) CONCLUSION Sonographyguidedparavertebral Sonography guided surgery 187 7 18– p000 p=0.00 00 (p=0.006 p00 p=0.0 (p=0.00 p0 p=0. (p=0.0 p=0 (p=0. p= (p=0 (p= (p

SUMMARY OBJECTIVE: Papillary thyroid carcinoma, per se, is the most common type of thyroid cancer, and Hashimoto's thyroiditis is the most frequent autoimmune disease of the papillon gland. The liaison between Hashimoto's thyroiditis and thyroid cancers is still an ongoing debate in thyroidology. The aim of the study was to discuss the frequency of the co-occurrence of Hashimoto's thyroiditis and papillary thyroid carcinoma. METHODS: This study is designed as a retrospective analytical cohort study. The institutional database and archive of histopathology scanning identified the patients who had undergone thyroidectomy between January 2022 and January 2016. The Statistical Package for Social Sciences v21.0 program was used for statistical purposes. Descriptive and chi-square tests were applied, and a p<0.05 was considered significant. RESULTS: Of 498 patients who had undergone thyroidectomy for 4 years, 99 (20%) were male and 399 (80%) were female. Of note, papillary thyroid carcinoma was revealed in 160 (32%) patients, and Hashimoto's thyroiditis was recognized in 178 (35.74%) patients. The prevalence of Hashimoto's thyroiditis in cases with papillary thyroid carcinoma was 43.8%, while the prevalence in patients with Hashimoto's thyroiditis was 41.1%. CONCLUSION: A debate still remains on the propriety of these two phenomena. Herewith, we recognized a correlation between the presence of papillary thyroid carcinoma and Hashimoto's thyroiditis. Providers should be vigilant about the coexistence of these phenomena. We might postulate the so-called total thyroidectomy for cases with a cytologic diagnosis of Hashimoto's thyroiditis with a papillary thyroid carcinoma. As a matter of fact, this issue merits further investigation. OBJECTIVE se cancer Hashimotos Hashimoto s gland thyroidology cooccurrence co occurrence METHODS 202 2016 v210 v v21 0 v21. purposes chisquare chi square applied p005 p 05 p<0.0 significant RESULTS 49 years 9 20% 20 (20% 39 80% 80 (80% female note 16 32% 32 (32% 17 35.74% 3574 35 74 (35.74% 438 43 8 43.8% 411 41 1 41.1% CONCLUSION phenomena Herewith socalled so called fact investigation 201 v2 p00 p<0. 2 (20 3 (80 (32 35.74 357 7 (35.74 43.8 41.1 p0 p<0 (2 (8 (3 35.7 (35.7 43. 41. p< ( 35. (35. (35

SUMMARY OBJECTIVE: Back to the sources, postoperative nausea and vomiting, hypo- and hypertension, heart rate alterations, and hypoxemia due to laryngospasm might be considered perioperative complications. METHODS: This cross-sectional study was conducted at an Education and Research Hospital between January 2018 and June 2023. The study included a total of 437 cases of thyroid surgery. The demographic data such as age, sex, co-morbidities of the instances, hypotension, hypertension, bradycardia, hypoxemia, and postoperative nausea and vomiting, as well as laboratory data were obtained and analyzed. RESULTS: Of 437 cases, 334 (76%) were females and 103 (24%) were males, with a mean age of 51.83±11.91 years and 55.32±11.87 years, respectively. No statistical significance was realized between the complications, co-morbid diseases, and age. Notably, no liaison between the complications after awakening from the anesthesia and preoperative laboratory parameters was discerned. However, a high but no significant relationship was revealed between the platelet-to-lymphocyte ratio (P/L) in cases with hypoxemia and hypotension. Finally, no significance between laboratory values, bradycardia, hypertension, and postoperative nausea and vomiting was distinguished. CONCLUSION: We postulate that the so-called inflammatory biomarkers measured at the time of preoperative examination in the blood count concept selectively do not enrich for anticipating complications that arise in the perioperative echelon. OBJECTIVE sources hypo hypertension alterations METHODS crosssectional cross sectional 201 2023 43 surgery sex comorbidities co morbidities instances hypotension bradycardia analyzed RESULTS 33 76% 76 (76% 10 24% 24 (24% males 51831191 51 83 11 91 51.83±11.9 55321187 55 32 87 55.32±11.8 respectively comorbid morbid diseases Notably discerned However platelettolymphocyte platelet lymphocyte P/L PL P L (P/L Finally values distinguished CONCLUSION socalled so called echelon 20 202 4 3 7 (76 1 2 (24 5183119 5 8 9 51.83±11. 5532118 55.32±11. (7 (2 518311 51.83±11 553211 55.32±11 ( 51831 51.83±1 55321 55.32±1 5183 51.83± 5532 55.32± 518 51.83 553 55.32 51.8 55.3 51. 55.

SUMMARY OBJECTIVE: Colonic diverticulosis might be caused by low-fiber dietary habits, gastrointestinal motility disorders, and colonic wall resistance changes, which might also affect the upper gastrointestinal system mucosa. Therefore, the present study aims to answer whether the gastric histopathological findings of the cases with diverge from those without. METHODS: This retrospective cross-sectional study included 184 cases who underwent both upper and lower gastrointestinal endoscopy procedures between January 2020 and December 2022. Notably, 84 cases were colonic diverticulosis, while the rest of the study group was control. Their demographic, laboratory, and histopathological findings were compared meticulously. RESULTS: The median ages for the colonic diverticulosis and control were 67.07±8.14 and 66.29±15.83 years, respectively, and no statistical difference concerning the age and gender distribution between them was recognized. The median levels of white blood cells, neutrophils, glucose, creatinine, and aspartate aminotransferase in colonic diverticulosis were significantly increased compared to control. As for pathological comparison, colonic diverticulosis had a higher prevalence of Helicobacter pylori (45.2 vs. 38%), while atrophy and intestinal metaplasia prevalence were nearly the same in the groups, without significance regarding Helicobacter pylori. CONCLUSION: Consequently, colonic diverticulosis should not be overlooked, particularly when the abovementioned laboratory parameters are augmented in a dyspeptic patient. A correlation might be raised between Helicobacter pylori and colonic diverticulosis. Eradication therapy might help attenuate the risk of colonic diverticulosis when Helicobacter pylori has emerged in a patient. OBJECTIVE lowfiber low fiber habits disorders changes mucosa Therefore METHODS crosssectional cross sectional 18 202 2022 Notably 8 demographic meticulously RESULTS 6707814 67 07 14 67.07±8.1 66291583 66 29 15 83 66.29±15.8 years respectively recognized cells neutrophils glucose creatinine comparison 45.2 452 45 2 (45. vs 38%, 38 38% , 38%) groups CONCLUSION Consequently overlooked patient 1 20 670781 6 0 67.07±8. 6629158 66.29±15. 45. 4 (45 3 67078 67.07±8 662915 66.29±15 (4 6707 67.07± 66291 66.29±1 ( 670 67.07 6629 66.29± 67.0 662 66.29 67. 66.2 66.

SUMMARY OBJECTIVE: Stroke is a chronic health problem that affects all areas of life. The presence of thyroid autoantibodies can augment the severity of stroke. The aim of this work is to investigate whether there is a relationship between the site of stroke involvement and the anti-thyroid peroxidase antibody (anti-TPO) or not. This is the first study in the English-language literature. METHODS: A total of 39 patients with a diagnosis of acute ischemic stroke were included, and the cases under 18 years of age with an infection and the ones with autoimmune diseases other than Hashimoto's thyroiditis were excluded from the study design. The patients’ age, gender, smoking status, comorbid conditions, and stroke localization in brain imaging were recorded. The region involving the anterior circulation area originating from the internal carotid artery was evaluated as anterior, and the region possessing the vertebrobasilar circulation area from the vertebral arteries was considered posterior involvement. Thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), C-reactive protein (CRP), sedimentation, and anti-TPO were retrospectively analyzed. RESULTS: As a consequence, gender distribution, smoking, comorbid conditions, TSH, T3, T4, triglyceride, HDL, LDL, CRP, and sedimentation did not differ significantly, while the age of the posterior-located stroke was lower than that of the cases with the anterior. The anti-TPO value was significantly lower in posterior-located strokes than in the anterior system. CONCLUSION: In summary, the anti-TPO value was recognized as higher in the anterior stroke localization. Thyroiditis and accompanying anti-TPO autoantibody positivity are conditions that should not be ignored by thyroidologists and thyroid-health providers. OBJECTIVE life antithyroid anti antiTPO TPO (anti-TPO Englishlanguage English language literature METHODS 3 included 1 Hashimotos Hashimoto s design status recorded Thyroidstimulating Thyroid stimulating TSH , (TSH) T3 T (T3) T4 (T4) triglyceride highdensity high density HDL (HDL) lowdensity low LDL (LDL) Creactive C reactive CRP (CRP) analyzed RESULTS consequence distribution posteriorlocated located system CONCLUSION summary thyroidhealth providers (TSH (T3 (T4 (HDL (LDL (CRP (T