ABSTRACT BACKGROUND: Stroke is a major cause of mortality worldwide. Renal dysfunction is an important risk factor for stroke. Brazilian studies on stroke knowledge are generally population based. Studies stratifying stroke knowledge according to comorbidities are rare. Scientific data are essential to guide the awareness of stroke. OBJECTIVE: To assess stroke knowledge in patients with chronic kidney disease (CKD) on hemodialysis. DESIGN AND SETTING: Cross-sectional analytical study of patients with CKD on hemodialysis in north-eastern Brazil. METHODS: A self-administered questionnaire survey on stroke awareness was administered to patients with CKD on hemodialysis between April and November 2022. The chi-square test and other descriptive statistics were used. Univariate and multivariate analyses were performed using logistic regression. RESULTS: A total of 197 patients were included in the analysis. The Brazilian acronym for stroke was used by 53.5% of the participants. Less than 10.0% of the sample showed optimal decision-making ability regarding stroke. Of the participants, 29.9% knew at least one risk factor and one symptom; however, this was considered as having below the minimum capacity because they did not know the emergency service call number. In the analysis adjusted for income and education, females (odds ratio [OR], 0.40%; 95% confidence interval [CI], 0.20-0.82), older patients (OR, 0.24%; 95% CI, 0.09-0.63) and having at most one comorbidity (OR, 0.48%; 95% CI, 0.23-0.98) were factors for lower levels of knowledge or ideal decision-making capacity against stroke. CONCLUSIONS: Patients on hemodialysis, especially women and older people, have little knowledge about stroke. BACKGROUND worldwide based rare OBJECTIVE (CKD SETTING Crosssectional Cross sectional northeastern north eastern Brazil METHODS selfadministered self 2022 chisquare chi square regression RESULTS 19 535 53 5 53.5 participants 100 10 0 10.0 decisionmaking decision making 299 29 9 29.9 symptom however number education odds OR, OR , [OR] 0.40% 040 40 95 CI [CI] 0.200.82, 020082 0.20 0.82 20 82 0.20-0.82) (OR 0.24% 024 24 0.090.63 009063 0.09 0.63 09 63 0.09-0.63 0.48% 048 48 0.230.98 023098 0.23 0.98 23 98 0.23-0.98 CONCLUSIONS people 202 1 53. 10. 2 29. [OR 0.40 04 4 [CI 200 0.200.82 02008 020 0.2 082 0.8 8 0.20-0.82 0.24 02 090 0.090.6 00906 009 0.0 063 0.6 6 0.09-0.6 0.48 230 0.230.9 02309 023 098 0.9 0.23-0.9 0.4 0.200.8 0200 0. 08 0.20-0.8 0.090. 0090 00 06 0.09-0. 0.230. 0230 0.23-0. 0.200. 0.20-0. 0.090 0.09-0 0.230 0.23-0 0.200 0.20-0 0.09- 0.23- 0.20-

ABSTRACT BACKGROUND: Respiratory failure is the most common cause of death in patients with amyotrophic lateral sclerosis (ALS), and morbidity is related to poor quality of life (QOL). Non-invasive ventilation (NIV) may be associated with prolonged survival and QOL in patients with ALS. OBJECTIVES: To assess whether NIV is effective and safe for patients with ALS in terms of survival and QOL, alerting the health system. DESIGN AND SETTING: Systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting standards using population, intervention, comparison, and outcome strategies. METHODS: The Cochrane Library, CENTRAL, MEDLINE, LILACS, EMBASE, and CRD databases were searched based on the eligibility criteria for all types of studies on NIV use in patients with ALS published up to January 2022. Data were extracted from the included studies, and the findings were presented using a narrative synthesis. RESULTS: Of the 120 papers identified, only 14 were related to systematic reviews. After thorough reading, only one meta-analysis was considered eligible. In the second stage, 248 studies were included; however, only one systematic review was included. The results demonstrated that NIV provided relief from the symptoms of chronic hypoventilation, increased survival, and improved QOL compared to standard care. These results varied according to clinical phenotype. CONCLUSIONS: NIV in patients with ALS improves the outcome and can delay the indication for tracheostomy, reducing expenditure on hospitalization and occupancy of intensive care unit beds. SYSTEMATIC REVIEW REGISTRATION: PROSPERO database: CRD42021279910 — https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=279910. BACKGROUND ALS, , (ALS) QOL. . (QOL) Noninvasive Non invasive (NIV OBJECTIVES system SETTING MetaAnalyses Meta Analyses population intervention comparison strategies METHODS Library CENTRAL MEDLINE LILACS EMBASE 2022 synthesis RESULTS 12 identified 1 reviews reading metaanalysis meta analysis eligible stage 24 however hypoventilation phenotype CONCLUSIONS tracheostomy beds REGISTRATION database CRD4202127991 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=279910. httpswwwcrdyorkacukprosperodisplayrecordphpRecordID279910 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID https //www.crd.york.ac.uk/prospero/display_record.php RecordID=279910. www crd york ac uk prospero display record php RecordID 279910 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=279910 (ALS (QOL 202 2 CRD420212799 phpRecordID https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=279910 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID27991 wwwcrdyorkacukprosperodisplayrecordphp RecordID279910 RecordID=279910 27991 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=27991 20 CRD42021279 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=27991 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID2799 RecordID27991 RecordID=27991 2799 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=2799 CRD4202127 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=2799 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID279 RecordID2799 RecordID=2799 279 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=279 CRD420212 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=279 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID27 RecordID279 RecordID=279 27 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=27 CRD42021 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=27 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID2 RecordID27 RecordID=27 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=2 CRD4202 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=2 RecordID2 RecordID=2 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID= CRD420 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID= RecordID= https://www.crd.york.ac.uk/prospero/display_record.php?RecordID CRD42 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID CRD4

RESUMEN Objetivo: comprender las percepciones sobre el uso de la tecnología móvil de salud en la adherencia al tratamiento de pacientes con enfermedad renal crónica en hemodiálisis. Método: estudio descriptivo, con enfoque cualitativo, realizado en una clínica de referencia en hemodiálisis de la ciudad de Juazeiro, Bahia, Brazil. Se incluyeron en el estudio pacientes en hemodiálisis renal crónica que utilizaron la aplicación Renal Health entre los meses de febrero y octubre de 2022. Los datos se analizaron mediante el método de análisis de contenido. Resultados: se entrevistaron 12 pacientes, la mayoría del sexo masculino, con una edad promedio de 35,3 (±9,7) años y un promedio de 2,7 (±1,5) años de hemodiálisis. Tras el análisis del contenido surgieron dos categorías temáticas: “Apoyo de la tecnología mHealth en la gestión del tratamiento” y “Sugerencias para mejorar la aplicación”, en el que los pacientes describen cómo la aplicación es práctica, favorece el almacenamiento de información relacionada con el tratamiento, como peso, ingesta de agua y tiempos de toma de medicamentos. Además de generar gráficos de los exámenes realizados mensualmente, brinda estrategias que pueden promover el autocontrol de la enfermedad y en consecuencia una mejor adherencia al tratamiento. Conclusión: la aplicación Renal Health demostró ser una herramienta útil capaz de mejorar el conocimiento sobre la enfermedad renal crónica y ayudar a los pacientes a gestionar mejor su dieta, control de líquidos y toma de medicamentos prescritos. Objetivo Método descriptivo cualitativo Juazeiro Bahia Brazil 2022 Resultados 1 masculino 353 35 3 35, ±9,7 97 9 7 (±9,7 27 2 2, ±1,5 15 5 (±1,5 temáticas Apoyo Sugerencias aplicación, , aplicación” práctica peso mensualmente Conclusión dieta prescritos 202 ±9, (±9, ±1, (±1, 20 ±9 (±9 ±1 (±1 ± (± (

ABSTRACT Objective: To understand the perceptions of mobile health technology use in adherence to the treatment of patients with chronic kidney disease under hemodialysis. Method: This is a descriptive study, with a qualitative approach, carried out in a reference hemodialysis clinic in the city of Juazeiro, Bahia, Brazil. Patients with chronic kidney disease under hemodialysis who used the Renal Health application between February and October 2022 were included in the study. The data was analyzed using the content analysis method. Results: A total of 12 patients were interviewed, the majority of whom were male, with an average age of 35.3 (±9.7) years and an average of 2.7 (±1.5) years of hemodialysis. After analyzing the content, two thematic categories emerged: “Support from mHealth technology in treatment management” and “Suggestions for improving the application”, in which patients describe how the application is practical, favors the storage of information related to treatment, such as weight, water intake and medication taking times. In addition to generating graphs of the exams carried out monthly, it provides strategies that can promote disease self-management and consequently better adherence to treatment. Conclusion: The Renal Health application proved to be a useful tool capable of enhancing knowledge about chronic kidney disease and helping patients better manage their diet, fluid control and taking prescribed medications. Objective Method study approach Juazeiro Bahia Brazil 202 method Results 1 interviewed male 353 35 3 35. ±9.7 97 9 7 (±9.7 27 2 2. ±1.5 15 5 (±1.5 emerged Support management Suggestions application, , application” practical weight times monthly selfmanagement self Conclusion diet medications 20 ±9. (±9. ±1. (±1. ±9 (±9 ±1 (±1 ± (± (

RESUMO Objetivo: compreender as percepções do uso de uma tecnologia mobile health na adesão ao tratamento do paciente renal crônico em hemodiálise Método: estudo descritivo, com abordagem qualitativa, realizado em uma clínica de referência em hemodiálise no município de Juazeiro, Bahia, Brasil. Foram incluídos no estudo pacientes renais crônicos hemodialíticos que utilizaram o aplicativo Renal Health entre os meses de fevereiro a outubro de 2022. Os dados foram analisados através do método análise de conteúdo Resultados: foram entrevistados 12 pacientes, a maioria do sexo masculino, idade média de 35,3 (±9,7) anos e média de 2,7 (±1,5) anos de hemodiálise. Após análise do conteúdo surgiram duas categorias temáticas: “Apoio da tecnologia mHealth no gerenciamento do tratamento” e “Sugestões para aperfeiçoamento do aplicativo”, nas quais os pacientes descrevem como o aplicativo é prático, favorece o armazenamento de informações relacionadas ao tratamento, como peso, ingestão hídrica e horário da tomada de medicamentos. Além de gerar gráficos dos exames realizados mensalmente, proporcionando estratégias que podem favorecer o autogerenciamento da doença e consequentemente uma melhor adesão ao tratamento. Conclusão: o aplicativo Renal Health, demonstrou ser uma ferramenta útil, capaz de potencializar o conhecimento sobre a doença renal crônica e auxiliar os pacientes a gerenciarem melhor a dieta, o controle de líquidos e a tomada das medicações prescritas. Objetivo Método descritivo qualitativa Juazeiro Bahia Brasil 2022 Resultados 1 masculino 353 35 3 35, ±9,7 97 9 7 (±9,7 27 2 2, ±1,5 15 5 (±1,5 temáticas Apoio Sugestões aplicativo, , aplicativo” prático peso medicamentos mensalmente Conclusão útil dieta prescritas 202 ±9, (±9, ±1, (±1, 20 ±9 (±9 ±1 (±1 ± (± (

ABSTRACT INTRODUCTION: Smartphone and application use can improve communication and monitoring of chronic diseases, including chronic kidney disease, through self-management and increased adherence to treatment. OBJECTIVE: To assess smartphone use in patients with chronic kidney disease on dialysis and their willingness to use mobile applications as a disease self-management strategy. DESIGN AND SETTING: This was a cross-sectional study of chronic kidney disease patients on hemodialysis in the São Francisco Valley in the Northeast Region, Brazil. METHODS: The questionnaire developed by the authors was administered between April and June 2021. Cronbach's alpha coefficient for the construct was 0.69. Associations between the dependent and independent variables were determined using univariate analysis. Multivariate analysis with logistic regression analysis was also performed. RESULTS: A total of 381 patients were included, of whom 64% had a smartphone, although only 3.1% knew of a kidney disease-related application. However, 59.3% believed that using an application could help them manage their disease. Having a smartphone was associated with treatment adherence, higher educational attainment, and higher per capita income. Educational attainment remained an independent factor in multivariate analysis. CONCLUSION: More than 64% of patients had a smartphone, although few knew of applications developed for kidney disease. More than half of the population believed that technology use could benefit chronic kidney disease treatment. Smartphone ownership was more common among the younger population, with higher educational attainment and income, and was associated with greater adherence to hemodialysis sessions. INTRODUCTION diseases selfmanagement self management OBJECTIVE strategy SETTING crosssectional cross sectional Region Brazil METHODS 2021 Cronbachs Cronbach s 069 0 69 0.69 performed RESULTS 38 included 64 31 3 1 3.1 diseaserelated related However 593 59 59.3 income CONCLUSION sessions 202 06 6 0.6 3. 5 59. 20 0. 2

ABSTRACT BACKGROUND: Coronavirus disease 2019 (COVID-19) can damage cardiac tissue by increasing troponin levels and inducing arrhythmias, myocarditis, and acute coronary syndrome. OBJECTIVES: To analyze the impact of COVID-19 on cardiac autonomic control in mechanically ventilated intensive care unit (ICU) patients. DESIGN AND SETTING: This cross-sectional analytical study of ICU patients of both sexes receiving mechanical ventilation was conducted in a tertiary hospital. METHODS: Patients were divided into COVID-19-positive (COVID(+)) and COVID-19-negative (COVID(-)) groups. Clinical data were collected and heart rate variability (HRV) records obtained using a heart rate monitor. RESULTS: The study sample comprised 82 subjects: 36 (44%) in the COVID(-) group (58.3% female; median age, 64.5 years) and 46 (56%) in the COVID(+) group (39.1% females; median age, 57.5 years). The HRV indices were lower than the reference values. An intergroup comparison identified no statistically significant differences in the mean normal-to-normal (NN) interval, standard deviation of the NN interval, or root mean square of successive differences in NN intervals. The COVID(+) group had an increased low frequency (P = 0.05), reduced high frequency (P = 0.045), and increased low frequency/high frequency (LF/HF) ratio (P = 0.048). There was a weak positive correlation between LF/HF and length of stay in the COVID(+) group. CONCLUSION: Patients who received mechanical ventilation had lower overall HRV indices. COVID(+) patients who received mechanical ventilation had lower vagal HRV components. These findings likely indicate clinical applicability, as autonomic control impairments are associated with a greater risk of cardiac death. BACKGROUND 201 COVID19 COVID 19 (COVID-19 arrhythmias myocarditis syndrome OBJECTIVES COVID-1 (ICU SETTING crosssectional cross sectional hospital METHODS COVID19positive COVIDpositive COVID+ + (COVID(+) COVID19negative COVIDnegative negative (COVID(-) groups (HRV monitor RESULTS 8 subjects 3 44% 44 (44% COVID(- 58.3% 583 58 (58.3 female age 645 64 5 64. years 4 56% 56 (56% COVID(+ 39.1% 391 39 1 (39.1 females 575 57 57. years. . values normaltonormal normal to (NN interval intervals P 0.05, 005 0.05 , 0 05 0.05) 0.045, 0045 0.045 045 0.045) frequencyhigh LFHF LF HF (LF/HF 0.048. 0048 0.048 048 0.048) CONCLUSION components applicability death 20 COVID1 (COVID-1 COVID- (COVID(+ (COVID(- (44 COVID( 58.3 (58. 6 (56 39.1 (39. 00 0.0 004 0.04 04 2 (COVID- (COVID( (4 58. (58 (5 39. (39 0. (COVID ( (3

ABSTRACT BACKGROUND: Stroke is one of the main causes of death worldwide. Educational interventions on stroke are potentially effective in reducing the period between the onset of symptoms and the initial emergency medical assistance. OBJECTIVES: To assess high school students’ knowledge of stroke. DESIGN AND SETTING: Cross-sectional study conducted in high schools in northeastern Brazil. METHODS: A self-structured questionnaire survey regarding stroke awareness was applied among high school students in northeastern Brazil. Data were collected between 2018 and 2019. The chi-square test and other descriptive statistics were used. Univariate and multivariate analyses were performed using logistic regression. RESULTS: A total of 1,788 students were analyzed. Eighty percent (n = 1430) of them did not have the minimum knowledge on how to act in a stroke situation. Only 10% (n = 179) presented the ideal knowledge on how to act. Males presented lower levels of knowledge on risk factors (odds ratio, OR: 0.62%; 95% confidence interval, CI: 0.49-0.79) and signs and symptoms of stroke (OR: 0.63%; 95% CI: 0.52-0.77). Students with ≥ 10 years of schooling (OR: 1.64%; 95% CI: 1.30-2.07) demonstrated greater knowledge of signs and symptoms of stroke. Students aged 18 years (OR: 1.70%; 95% CI: 1.14-2.52) demonstrated greater knowledge than other ages regarding the telephone number of the emergency medical services. CONCLUSIONS: There was a knowledge deficit with regard to recognizing stroke and activating the emergency medical services. The findings apply to the sample investigated and suggest that there is a need for stroke educational interventions, starting in high school.

ABSTRACT INTRODUCTION: Smartphone and application use can improve communication and monitoring of chronic diseases, including chronic kidney disease, through self-management and increased adherence to treatment. OBJECTIVE: To assess smartphone use in patients with chronic kidney disease on dialysis and their willingness to use mobile applications as a disease self-management strategy. DESIGN AND SETTING: This was a cross-sectional study of chronic kidney disease patients on hemodialysis in the São Francisco Valley in the Northeast Region, Brazil. METHODS: The questionnaire developed by the authors was administered between April and June 2021. Cronbach's alpha coefficient for the construct was 0.69. Associations between the dependent and independent variables were determined using univariate analysis. Multivariate analysis with logistic regression analysis was also performed. RESULTS: A total of 381 patients were included, of whom 64% had a smartphone, although only 3.1% knew of a kidney disease-related application. However, 59.3% believed that using an application could help them manage their disease. Having a smartphone was associated with treatment adherence, higher educational attainment, and higher per capita income. Educational attainment remained an independent factor in multivariate analysis. CONCLUSION: More than 64% of patients had a smartphone, although few knew of applications developed for kidney disease. More than half of the population believed that technology use could benefit chronic kidney disease treatment. Smartphone ownership was more common among the younger population, with higher educational attainment and income, and was associated with greater adherence to hemodialysis sessions.

Abstract Introduction Asymptomatic patients with moderate functional capacity do not require Coronary Artery Disease (CAD) workup in the preoperative period of non-cardiac surgeries, especially when scheduled for minor and intermediate-risk surgeries. The workup is inappropriate because it promotes over diagnosing and pointless treatments. Moreover, those patients usually undergo cardiology assessment, in addition to pre-anesthetic evaluation. Objective Investigate the role of cardiology consultation as mediator in inappropriate assessment of CAD for preoperative of non-cardiac surgeries. Method Retrospective study performed in a private anesthesia service using medical charts of asymptomatic patients with a history of controlled systemic disease and moderate functional capacity, submitted to pre-anesthetic consultation for minor and intermediate risk surgeries. Cardiology consultations were identified by the presence of a consultation report by a cardiologist. CAD workup was defined as undergoing cardiac stress tests. Results We included 390 medical charts of patients with mean age of 48.6 ± 15.4 years, 67% women and 69% intermediate risk surgeries. CAD workup was infrequent and performed in 3.9% of patients. Besides, pre-anesthetic evaluation, 93 (24%) patients had a cardiology consultation. Among those patients, 15.1% were submitted to CAD workup, compared to 0.34% of patients without cardiology assessment (p< 0.001; RR = 4.4; 95% CI: 3.5–5.6). Conclusions Inappropriate testing for CAD investigation is infrequent for asymptomatic individuals submitted to minor and intermediate risk surgeries. However, cardiology consultation increases substantially the likelihood of a patient undergoing CAD workup, suggesting that, unlike the anesthesiologist, the cardiologist is a major mediator of this kind of management.

RESUMO Objetivo: avaliar as características demográficas e clínicas associadas ao desenvolvimento de pneumonia em pacientes após acidente vascular encefálico internados em um hospital terciário do Vale do São Francisco que atende os estados de Pernambuco e Bahia, Brasil. Métodos: trata-se de estudo unicêntrico, observacional, analítico e transversal realizado a partir dos prontuários de pacientes com diagnóstico de acidente vascular encefálico incluídos no Registro de Acidente Vascular Encefálico (Estudo RAVESS). A análise estatística foi composta pelos testes qui-quadrado, exato de Fisher e a análise de variância com pós-teste de Bonferroni com nível de P≤0,05. Resultados: foram coletados dados de 69 pacientes com AVE agudo com média±desvio padrão de idade de 63,2±16,8 anos, sendo 37 (53,6%) do sexo feminino, com prevalência de pneumonia durante o internamento estimada em 31,9% (Intervalo de Confiança de 95%: 21,2-44,2%). Na análise univariada para preditores de pneumonia após acidente vascular encefálico foram identificados: idade mais avançada (72,6±17,9 vs. 58,8±14,5; P=0,001), menor sinal de resposta a escala de coma de Glasgow durante a admissão (11,3±1,8 vs. 13,3±2,1; P=0,001) e maior frequência de disartria na admissão (61,9% vs. 27,9%; P=0,009). Conclusão: a pneumonia foi uma complicação prevalente em pacientes após acidente vascular encefálico de um hospital terciário brasileiro, tendo sido relacionada com idade avançada do paciente e a severidade do evento encefálico.

ABSTRACT Purpose: to assess the demographic and clinical characteristics associated with the development of pneumonia in post-stroke patients hospitalized in a tertiary hospital, located in the Vale do São Francisco, that covers the states of Pernambuco and Bahia, Brazil. Methods: a unicentric, observational, analytical, cross-sectional study, based on the medical records of patients diagnosed with stroke and included in the Stroke Registry (RAVESS study). The statistical analysis was made with the chi-square test, Fisher’s exact test, and the analysis of variance, with the Bonferroni’s post-test, and P≤0.05. Results: data from 69 patients presented with acute stroke were collected, aged 63.2±16.8 years; 37 (53.6%) were females; the prevalence of pneumonia during hospital stay was estimated at 31.9% (95% confidence interval: 21.2-44.2%). In the univariate analysis of predictors for post-stroke pneumonia, the following were identified: older age (72.6±17.9 vs. 58.8±14.5; P = 0.001), lower response signal to the Glasgow Coma Scale at admission (11.3±1.8 vs. 13.3±2.1; P = 0.001), and higher frequency of dysarthria at admission (61.9% vs. 27.9%; P = 0.009). Conclusion: pneumonia was a prevalent complication in post-stroke patients at a Brazilian tertiary hospital. It was related to the patient’s older age and the severity of the cerebral event.

Abstract Negative changes in cardiovascular and autonomic variables in stroke survivors have encouraged the global scientific community to focus on investigating therapeutic strategies to mitigate stroke damage. The objective of the present study was to describe the effects of exercise training on cardiovascular and autonomic variables in stroke survivors. We used the PICO (population, intervention, control/comparison, and outcome variables) model for the search of articles in PubMed and Physiotherapy Evidence Databases from 2009 to December 2018. The following data were also recorded: type of study, author, year of publication, participants (time after stroke, sample size, and age) and benefits of exercise training. A total of 544 articles were initially selected, of which nine peer-reviewed articles met the search criteria. These nine studies enrolled 611 participants (middle-aged or elderly), and pointed to positive effects of training on maximal oxygen uptake, peak aerobic capacity, 6-minute walk test and resting heart rate. However, more well-controlled studies are needed to confirm the benefits of exercise training on cardiovascular and autonomic variables in this population.

Abstract Purpose To assess Cyclosporine A (CsA) therapy at an intraperitoneal dose of 15 mg.kg -1 in a rodent model of non-septic renal ischemia. Methods Twenty male Wistar rats were randomized to receive CsA therapy or none therapy before undergoing 30 minutes of renal ischemia followed by reperfusion. Additionally, 10 rats were randomized to undergo the same surgical procedure of the aforementioned animals with neither ischemia nor CsA therapy. Twelve hours after kidney ischemia, the left kidneys were evaluated for histological injury according to Park’s criteria. Serum creatinine (Cr), urea nitrogen (Ur) and sodium levels were obtained at different times of the experimental protocol. Results Rodents in the CsA group showed negative results (p<0.05) in serum variables (Cr: 0.41±0.05mg/dL vs . 4.17±1.25mg/dL; Ur: 40.90±3.98mg/dL vs . 187.70±22.93mg/dL) even the non CsA or control group (Cr: 0.35±0.07mg/dL vs . 3.80±1.20mg/dL; Ur: 40.10±4.70mg/dL vs . 184.50±49.80mg/dL). The negative results were also verified in histological evaluation, CsA group had 50% in the very severe grade of lesion, 10% in the severe and 40% in the moderate to severe whereas the control group had 90% in the very severe grade. Conclusion CsA was incapable of preventing the deleterious effects of ischemia-reperfusion injury in rat kidneys.

RESUMO Objetivo: O estudo teve como objetivo verificar a associação entre alterações posturais e a prática do balé clássico em bailarinas da Região Administrativa Integrada de Desenvolvimento (RIDE) do Polo Petrolina/PE e Juazeiro/BA. Métodos: Estudo observacional de corte transversal com 19 bailarinas com idade superior a 15 anos e, no mínimo, 5 anos ininterruptos de prática de balé clássico. A avaliação antropométrica consistiu na aferição da massa corporal total, na mensuração da estatura e no cálculo do índice de massa corporal (IMC). A avaliação postural ocorreu através do método fotogramétrico por meio dos software Posturograma(r) e SAPO(c). Resultados: A média de idade foi 25,3 ± 11,7 anos e a média do IMC foi 21,4 ± 2,9 kg/m2. Aproximadamente 74% das bailarinas clássicas apresentaram perfil antropométrico normal. O padrão postural das bailarinas mostrou inclinação e protrusão da cabeça, rotação do tronco, retificação da lordose cervical, aumento da cifose torácica, aumento da lordose lombar, inclinação e anteversão pélvica. Conclusão: A prática do balé levou a alterações no alinhamento corporal das bailarinas avaliadas. Os resultados sinalizam para a necessidade de reeducação postural, de modo a contribuir com o equilíbrio cinético-funcional de praticantes de balé clássico.

ABSTRACT Objective: The study aimed to determine the association between postural changes and practice of classical ballet among ballerinas from Integrated Administrative Region of Development (RIDE) in Polo Petrolina/PE and Juazeiro/BA. Methods: Cross-sectional observational study with 19 classical ballerinas aged over 15 years and at least 5 years of uninterrupted classical ballet practice. The anthropometric assessment included measurements of total body mass, height and body mass index (BMI). Postural evaluation was performed using the photogrammetric method with help of Posturograma(r) and SAPO(c) software. Results: The mean age was 25.3±11.7 years and the mean BMI was 21.4±2.9 kg/m². Approximately 74% of classical ballerinas had normal anthropometric profile. The postural profile of the classical ballerinas showed inclination and protrusion of the head, trunk rotation, rectification of cervical lordosis, increased thoracic kyphosis, increased lumbar lordosis, pelvic inclination and anteversion. Conclusion: The practice of ballet led to changes in body alignment of the classical ballerinas evaluated. The results points out to the need of postural re-education in order to contribute for the kinetic-functional balance of classical ballet practitioners.

RESUMEN Objetivo: El objetivo del estudio fue determinar la asociación entre los cambios posturales y la práctica de bailarinas del ballet clásico de la Región Administrativa Integrada de Desarrollo (RIDE) en Polo Petrolina/PE y Juazeiro/BA. Métodos: Estudio transversal observacional con 19 bailarinas clásicas mayores de 15 años y al menos 5 años de práctica de ballet clásico ininterrumpida. La evaluación antropométrica incluyó medición de índice de masa de masa corporal total, de la altura y el cálculo del índice de masa corporal (IMC). La evaluación postural se realizó mediante el método fotogramétrico y los software Posturograma(r) y SAPO(c). Resultados: La edad media fue de 25,3 ± 11,7 años y la media del IMC fue de 21,4 ± 2,9 kg/m². Aproximadamente el 74% de las bailarinas clásicas tenía perfil antropométrico normal. El perfil postural estándar de las bailarinas clásicas mostró inclinación y protrusión de la cabeza, la rotación del tronco, corrección de la lordosis cervical, aumento de cifosis torácica, aumento de la lordosis lumbar, inclinación y anteversión de la pelvis. Conclusión: La práctica del ballet llevó a cambios en la alineación del cuerpo de las bailarinas clásicas evaluadas. Los resultados señalan la necesidad de re-educación postural para contribuir al equilibrio cinético-funcional de las bailarinas clásicas.

Contexto Doença hepática gordurosa não alcoólica (DHGNA) é uma das mais frequentes hepatopatias crônicas da atualidade. Associa-se à síndrome metabólica e doenças cardiovasculares. Objetivo Avaliar a frequência e relevância da DHGNA em pacientes com doença arterial coronariana (DAC). Métodos Foram avaliados pacientes de uma área do Nordeste de Brasil, submetidos à angiografia coronariana, com suspeita de DAC, entre 2009-2010. Critérios para DAC: presença de lesões obstrutivas em artérias coronárias epicárdicas ou seus principais ramos. Critérios para DHGNA: esteatose hepática na ultrassonografia; exclusão de outras doenças hepáticas; ingestão de etanol ≤20g/dia. Análise estatística incluiu os testes t, Mann-Whitney e qui-quadrado de Pearson. Análise de regressão multivariada mediu a força da correlação entre fatores de risco e concomitância de DAC e DHGNA. Resultados Foram avaliados 244 pacientes submetidos à angiografia coronariana: 63,5% apresentavam DAC e 42,2% DHGNA. DHGNA foi observada em 43,9% dos doentes com DAC. A análise de regressão mostrou que a possibilidade de ocorrência concomitante de DAC e DHGNA foi positivamente correlacionadas à resistência a insulina e ao sobrepeso/obesidade. Conclusão DHGNA foi frequente entre os pacientes com DAC; resistência à insulina e sobrepeso/obesidade foram os mais relevantes fatores de risco relacionados à associação DHGNA e DAC. Os dados sugerem que pacientes com DAC devem ser avaliados para DHGNA.

Background Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver injury around the world. It is associated with metabolic syndrome and cardiovascular diseases. Objective To evaluate the frequency and relevance of NAFLD in patients with coronary artery disease (CAD). Methods Patients from a Brazil Northeast area, who underwent elective coronary angiography (CAG) from 2009 to 2010 were included. All of them had suspicion of CAD. Criteria to CAD: presence of obstructive lesions in the epicardial coronary arteries, or in their major branches. NAFLD criteria: presence of hepatic steatosis on ultrasound; exclusion of other liver diseases; ethanol intake ≤ 20g/day. Statistics analysis included Independent t-test, Mann-Whitney and Pearson’s chi-squared test. Multivariate regression analysis measured the relationship between the risk factors and the concomitant presence of CAD and NAFLD. Results A total of 244 patients were evaluated: 63.5% had CAD and 42.2% had NAFLD. NAFLD was observed in 43.9% of the CAD patients. The regression analysis showed that the relationship between CAD and NAFLD was positively correlated with HOMA-IR ≥3.0 or insulin resistance and overweight/obesity. Conclusion NAFLD was frequent among CAD patients; insulin resistance and overweight/obesity were the most relevant risk factors related to the association NAFLD and CAD. The results suggest that patients with CAD should be evaluated for NAFLD.

Objective: the objective was to assess the level of physical activity (LPA) and the quality of life QL of the professionals who work in ICU. Method: this was a cross-sectional study carried out in Adult ICUs. LPA was assessed by the International Questionnarie of Physical Activity - short form (IQPA-SF) and the QL by the Medical Outcomes Study 36 (SF-36) questionnaire. Results: it was classified active 50.89% out of a total of 59 professionals. Nursing technicians were considered the most active with 60.6%. The QL of the professionals who were considered active were better when compared to inactives, with statistical differences to the category of physical aspects limitation, social aspects and mental health. The working hours were higher than recommend, the physicians were higher than the physical therapist, nurses and technicians nurses (p = 0.046). Conclusion: physically active professionals who work in ICU had higher quality of life probably why have lower hours of work and consequently more free time to engage in physical activity.

Objetivo: el objetivo de este estudio fue evaluar el nivel de actividad física (NAF) y la calidad de vida (QOL) de los profesionales que trabajan en la unidad de cuidados intensivos (UCI). Método: este fue un estudio transversal realizado en clínicas UCI de adultos, donde el NAF fue evaluado por el Cuestionario Internacional de Actividad Física (IPAQ) y la calidad de vida a través del Medical Outcomes Study 36 (SF-36). Resultados: los activos fueron 50,85% de 59 profesionales, técnicos y enfermeras consideran los más activos (60,6%). La calidad de vida de los profesionales en activo fue mejor en comparación con los inactivos, con diferencias estadísticas para los dominios limitados por aspecto físico, social y de salud mental. La jornada de trabajo estaba por encima de los niveles recomendados, son más grandes que las de los fisioterapeutas médicos, enfermeras y auxiliares de enfermería (p = 0,04). Conclusión: profesionales físicamente activos en la UCI ha mejorado la calidad de vida, probablemente porque tienen una carga de trabajo más pequenos y por lo tanto más tiempo libre para participar en actividades físicas.

Objetivo: o objetivo deste estudo foi avaliar o nível de atividade física (NAF) e a qualidade de vida (QV) dos profissionais que trabalham em Unidade de Terapia Intensiva (UTI). Método: tratou-se de um estudo transversal realizado em UTIs clínicas adultos, onde o NAF foi avaliado pelo questionário internacional de atividade física (IPAQ) e a QV através do questionário Medical Outcomes Study 36 (SF-36). Resultados: estavam ativos 50,85% de 59 profissionais, sendo os técnicos de enfermagem considerados os mais ativos (60,6%). A QV dos profissionais ativos foi melhor quando comparados aos inativos, com diferenças estatísticas para os domínios limitação por aspectos físicos, aspecto social e saúde mental. A jornada de trabalho estava acima do recomendado, sendo a dos médicos maiores que as dos fisioterapeutas, enfermeiros e técnicos de enfermagem (p = 0,04). Conclusão: profissionais de UTI fisicamente ativos apresentaram maior qualidade de vida provavelmente por possuírem uma menor jornada de trabalho e consequentemente mais tempo livre para realizar atividades físicas.

Objetivo: o objetivo deste estudo foi avaliar o nível de atividade física (NAF) e a qualidade de vida (QV) dos profissionais que trabalham em Unidade de Terapia Intensiva (UTI). Método: tratou-se de um estudo transversal realizado em UTIs clínicas adultos, onde o NAF foi avaliado pelo questionário internacional de atividade física (IPAQ) e a QV através do questionário Medical Outcomes Study 36 (SF-36). Resultados: estavam ativos 50,85% de 59 profissionais, sendo os técnicos de enfermagem considerados os mais ativos (60,6%). A QV dos profissionais ativos foi melhor quando comparados aos inativos, com diferenças estatísticas para os domínios limitação por aspectos físicos, aspecto social e saúde mental. A jornada de trabalho estava acima do recomendado, sendo a dos médicos maiores que as dos fisioterapeutas, enfermeiros e técnicos de enfermagem (p = 0,04). Conclusão: profissionais de UTI fisicamente ativos apresentaram maior qualidade de vida provavelmente por possuírem uma menor jornada de trabalho e consequentemente mais tempo livre para realizar atividades físicas.

Objective: the objective was to assess the level of physical activity (LPA) and the quality of life QL of the professionals who work in ICU. Method: this was a cross-sectional study carried out in Adult ICUs. LPA was assessed by the International Questionnarie of Physical Activity - short form (IQPA-SF) and the QL by the Medical Outcomes Study 36 (SF-36) questionnaire. Results: it was classified active 50.89% out of a total of 59 professionals. Nursing technicians were considered the most active with 60.6%. The QL of the professionals who were considered active were better when compared to inactives, with statistical differences to the category of physical aspects limitation, social aspects and mental health. The working hours were higher than recommend, the physicians were higher than the physical therapist, nurses and technicians nurses (p = 0.046). Conclusion: physically active professionals who work in ICU had higher quality of life probably why have lower hours of work and consequently more free time to engage in physical activity.

Objetivo: el objetivo de este estudio fue evaluar el nivel de actividad física (NAF) y la calidad de vida (QOL) de los profesionales que trabajan en la unidad de cuidados intensivos (UCI). Método: este fue un estudio transversal realizado en clínicas UCI de adultos, donde el NAF fue evaluado por el Cuestionario Internacional de Actividad Física (IPAQ) y la calidad de vida a través del Medical Outcomes Study 36 (SF-36). Resultados: los activos fueron 50,85% de 59 profesionales, técnicos y enfermeras consideran los más activos (60,6%). La calidad de vida de los profesionales en activo fue mejor en comparación con los inactivos, con diferencias estadísticas para los dominios limitados por aspecto físico, social y de salud mental. La jornada de trabajo estaba por encima de los niveles recomendados, son más grandes que las de los fisioterapeutas médicos, enfermeras y auxiliares de enfermería (p = 0,04). Conclusión: profesionales físicamente activos en la UCI ha mejorado la calidad de vida, probablemente porque tienen una carga de trabajo más pequenos y por lo tanto más tiempo libre para participar en actividades físicas.