ABSTRACT Objective: To analyse pharmacological overlap in patients with autism spectrum disorder (ASD) under conscious sedation in a dental office environment, identifying any potential risks and complications. Material and Methods: A critical review was conducted by selecting articles from online databases (Pubmed and Lilacs), using a search algorithm and eligibility criteria. The Medscape® platform was used to verify interactions between drugs commonly used by patients with ASD and medications used for sedation in paediatric dentistry. Results: Due to their polydrug use, children with ASD are at risk of complications, namely Serotonin Syndrome (SS), Neuroleptic Malignant Syndrome (NMS), increase or decrease of the QT interval (QTi) and Torsade de Pointes (TdP), due to pre-existence of metabolic syndrome, deepening the sedation level or even leading to a decrease in the sedative capacity of the drugs used. Conclusion: It is essential to assess better drug interaction in ASD patients submitted to sedation. The severity of the disorder and the need for sedation for dental treatment are directly proportional. However, increases in sedative doses tend to increase risks and complications in children with ASD. Objective (ASD environment Methods Pubmed Lilacs, Lilacs , Lilacs) criteria Medscape dentistry Results use SS, SS (SS) NMS, NMS (NMS) QTi (QTi TdP, TdP (TdP) preexistence pre existence syndrome Conclusion proportional However (SS (NMS (TdP

ABSTRACT Objective: To evaluate the influence of non-invasive treatment associated with the use of infiltrating resin for managing caries lesions in primary teeth. Material and Methods: A systematic review was performed by selecting articles from 6 online databases, using a search algorithm and eligibility criteria for data extraction and data synthesis for the papers included. Clinical trials involving primary teeth with incipient caries lesions (1/2 of the enamel or 1/3 of the outer dentin) were included, presenting full text and answering the study's guiding question. This study used the RoB 2 tool for the risk of bias assessment and GRADE for certainty of evidence. Random effects meta-analyses were implemented, and lesion progression treatment effects were estimated through relative risk (RR) and associated 95% confidence intervals. Results: A total of 440 studies were found. After analyzing the inclusion criteria and removal of duplicates, eight studies were analyzed for quality evidence. Five of the eight studies included in this review contributed to the meta-analysis, all with some reflections regarding the risk of bias. Overall, the results of the meta-analysis showed that non-invasive treatment, when associated with the use of infiltrating resins, significantly reduced the risk of caries progression in relation to the treatment without this addition for follow-up periods ranging from 12 months to 2 years (RR 0.51 [0.40-0.65]). Conclusion: There is moderate certainty of evidence that the use of infiltrating resins associated with non-invasive treatments decreases the risk of caries progression in primary teeth with incipient caries lesions (1/2 of the enamel or 1/3 of the dentin outer) when combined with non-invasive control methods alone. Objective noninvasive non invasive Methods databases 1/2 1 (1/ 13 3 1/ studys s question metaanalyses meta analyses implemented RR 95 intervals Results 44 found duplicates metaanalysis, metaanalysis analysis, analysis Overall followup follow up 051 0 51 0.5 0.400.65. 040065 0.40 0.65 . 40 65 [0.40-0.65]) Conclusion alone (1 9 4 05 5 0. 400 0.400.65 04006 040 0.4 065 0.6 [0.40-0.65] ( 0.400.6 0400 04 06 [0.40-0.65 0.400. [0.40-0.6 0.400 [0.40-0. [0.40-0 [0.40- [0.40 [0.4 [0. [0 [

ABSTRACT This paper discusses the potential risk that COVID-19 generates for the development of enamel defects. This hypothesis was built based on the etiopathogenesis of enamel defects and the relationship with the symptom's characteristic of COVID-19. Pregnancy is a critical period for the child's development; exposure to pathological agents can cause systemic imbalances and risks of adverse perinatal and prenatal outcomes. The main clinical symptoms of this disease and its association with that dental outcome were considered. Fever, breathing, cardiovascular disorders, and diarrhea were related as potential etiological factors of ameloblast metabolism imbalance, which can interfere qualitatively and quantitatively in the development, maturation and mineralization of the tooth enamel. Molecular disorders derived from COVID-19, as well as their clinical symptoms, can be considered potential risk factors for the development of enamel defects. Individuals with enamel defects experienced high stress levels during pregnancy or early childhood. The approach adopted may help build new research to ensure understanding of the etiology of the development of dental enamel defects and its relationship with COVID-19. However, longitudinal studies need to be conducted to confirm the association between COVID-19 and adverse events during pregnancy.

OBJETIVO: O Diamino fluoreto de prata, uma solução de fácil aplicação e que não precisa de um ambiente clínico para o seu uso, é um agente de notável capacidade de paralisar e prevenir cárie. Outro método simples e eficaz para o tratamento da cárie em crianças são Restaurações provisórias. Este estudo examinou o surgimento de efeitos adversos em escolares tratadas com Diamino fluoreto de prata (DFP) comparado com aquelas tratadas com o Tratamento Restaurador Provisório. METODOLOGIA: Foi realizado um estudo piloto de três meses comparando os efeitos adversos das restaurações provisórias, utilizando cimento de ionômero de vidro Fuji IX (GC America, Inc.), com o Diamino fluoreto de prata a 30% (Cariostop Biodinâmica®, Brasil), em 50 crianças com 6 anos de idade. RESULTADOS: O grupo DFP teve todas as suas cáries paralisadas e não apresentou dor, abscesso ou fístula. Das crianças tratadas com Fuji IX, 24% delas relataram dor de dente (P < 0,05). Para fístula e abscesso, não foi verificado diferença estatisticamente significativa. CONCLUSÃO: Os autores sugerem que, para crianças portadoras de cárie, sem acesso aos serviços de saúde, o DFP apresentou menos efeitos adversos do que o tratamento restaurador provisório utilizando FUJI IX.

PURPOSE: Silver diamine fluoride (SDF) is a caries prevention and arresting agent that is easy to apply clinically. Interim therapeutic restorations (IRT) are also known to be a simple and effective method for treating caries in children. This study examines whether treatment with 30% silver diamine fluoride (SDF) will cause fewer adverse events than the available interim therapeutic restorations in underprivileged schoolchildren with cavities. METHODS: We conducted a three-month pilot study comparing the adverse effects of IRT using glass ionomer cement (Fuji IX, GC America, Inc.) with those of 30% silver diamine fluoride (Cariostop Biodynamic®, Brazil) in 50 children aged 6 years. RESULTS: In the SDF group, all caries were arrested and no pain, abscess or fistula was reported. Of the children assigned to the Fuji IX group, 24% reported toothache (P < 0.05). There was no significant difference in the occurrence of fistula and abscess in the two groups. CONCLUSION: The authors suggest that for underprivileged schoolchildren with caries, the use of SDF when an appropriate clinical setting is not available resulted in fewer adverse effects than did treatment with an interim therapeutic restorative using FUJI IX.