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Abstract Sjogren’s disease (SjD) is an autoimmune disease that is characterized not only by the sicca symptoms it causes but also by its systemic nature, which is capable of several and not yet fully understood extraglandular manifestations. To gain a clearer understanding of these manifestations as well as a better practical approach, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of epidemiologic and clinical features of the extraglandular manifestations present in ESSDAI (EULAR Sjogren´s syndrome disease activity index), followed by a voting panel with recommendations for clinical practice. This publication is complementary to others already published and covers cutaneous and hematological manifestations, with prevalence data generated by a meta-analysis of 13 clinical or laboratory manifestations and 6 clinical management recommendations. Sjogrens Sjogren s SjD (SjD nature approach metaanalysis meta analysis EULAR index, index , index) practice 1

https://doi.org/10.1186/s42358-024-00391-x

Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary Sjögren syndrome: results of an epidemiologic systematic review/ meta-analysis and a consensus guideline from the Brazilian society of rheumatology (hepatic, gastrointestinal and pancreatic)
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Trevisani, Virginia Fernandes Moça

; Pinheiro, Aysa César

; Fialho, Sonia Cristina de Magalhães Souza

; Fernandes, Marilena Leal Mesquita Silvestre

; Pugliesi, Alisson

; Pasoto, Sandra Gofinet

; Lopes, Maria Lucia Lemos

; Guedes, Lissiane Karine Noronha

; Miyamoto, Samira Tatiyama

; Santos, Laura Caldas dos

; Appenzeller, Simone

; Fidelix, Tania

; Ribeiro, Sandra Lúcia Euzébio

; Brito, Danielle Christinne Soares Egypto de

; Libório-Kimura, Tatiana Nayara

; Santos, Maria Carmen Lopes Ferreira Silva

; Cantali, Diego Ustárroz

; Gennari, Juliana D.’Agostino

; Capobianco, Karina Gatz

; Civile, Vinicius Tassoni

; Pinto, Ana Carolina Pereira Nunes

; Rocha, Aline Pereira da

; Rocha Filho, César Ramos

; Oliveira, Fabiola Reis

; Valim, Valeria

Advances in Rheumatology

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2022, Volume 62 elocation 35

Abstract: En | Text: En | PDF: En

Abstract Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs, associated with sicca syndrome but also with systemic involvement with varying degrees of severity. Despite their importance, some systemic manifestations, mainly liver, gastrointestinal, and pancreatic are not routinely evaluated. To address these manifestations, the Sjögren's Syndrome Committee of the Brazilian Society of Rheumatology conducted a broad systematic review of the literature on studies investigating prevalence and diagnosis of these symptoms in Sjogren´s patients and made recommendations based on the findings. Agreement between the experts was achieved using the Delphi method. This is the second part of this guideline, providing 6 recommendations for liver, gastrointestinal, and pancreatic care of SS patients.

https://doi.org/10.1186/s42358-022-00267-y

Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary sjogren syndrome: results of an epidemiologic systematic review/ meta-analysis and a consensus guideline from the Brazilian Society of Rheumatology (articular, pulmonary and renal)
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Trevisani, Virginia Fernandes Moça

; Pugliesi, Alisson

; Pasoto, Sandra Gofinet

; Lopes, Maria Lucia Lemos

; Guedes, Lissiane Karine Noronha

; Miyamoto, Samira Tatiyama

; Fernandes, Marilena Leal Mesquita Silvestre

; Fialho, Sonia Cristina de Magalhães Souza

; Pinheiro, Aysa César

; Santos, Laura Caldas dos

; Appenzeller, Simone

; Fidelix, Tania

; Ribeiro, Sandra Lúcia Euzébio

; Brito, Danielle Christinne Soares Egypto de

; Libório-Kimura, Tatiana Nayara

; Santos, Maria Carmen Lopes Ferreira Silva

; Cantali, Diego Ustárroz

; Gennari, Juliana D’Agostino

; Civile, Vinicius Tassoni

; Pinto, Ana Carolina Pereira Nunes

; Rocha-Filho, César Ramos

; Oliveira, Fabiola Reis

; Rocha, Aline Pereira da

; Valim, Valeria

Advances in Rheumatology

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2022, Volume 62 elocation 18

Abstract: En | Text: En | PDF: En

Abstract Sjogren’s Syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs, associated with sicca syndrome but also with systemic involvement with varying degrees of severity. Despite their importance, these systemic manifestations are not routinely evaluated and there is no homogenous approach to their diagnosis or evaluation. To close this gap, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of epidemiologic and clinical features of these manifestations and made recommendations based on the findings. Agreement between the experts was achieved using the Delphi method. The first part of this guideline summarizes the most important topics, and 11 recommendations are provided for the articular, pulmonary, and renal care of SS patients.

https://doi.org/10.1186/s42358-022-00248-1

Infecções sexualmente transmissíveis em mulheres afrodescendentes de comunidades quilombolas no Brasil: prevalência e fatores associados
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Dias, Jerusa Araujo

; Luciano, Thaís Verly

; Santos, Maria Carmen Lopes Ferreira Silva

; Musso, Carlos

; Zandonade, Eliana

; Spano, Liliana Cruz

; Miranda, Angelica Espinosa

Cadernos de Saúde Pública

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2021, Volume 37 N. 2 elocation e00174919

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo: O objetivo do estudo foi estimar a prevalência de infecções sexualmente transmissíveis (IST) e fatores associados sobre mulheres quilombolas no Brasil. Trata-se de estudo transversal de base populacional com mulheres quilombolas no período de março de 2017 a janeiro de 2019. Utilizou-se um questionário com informações sociodemográficas, comportamentais e clínicas. Foi realizado exame ginecológico para coleta de células cervicais para citologia oncótica e para detecção de Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis e papilomavírus humano (HPV), por meio de teste de reação em cadeia pela polimerase. Foi realizado teste rápido para HIV e sífilis. O desfecho principal foi definido como a infecção por um ou mais agentes infecciosos de transmissão sexual. Para a análise, utilizou-se o teste do qui-quadrado e regressão logística hierárquica. De um total de 380 mulheres, 352 (92,6%) foram incluídas no estudo. A prevalência de, pelo menos, uma IST foi de 18,5% (IC95%: 14,76-22,85). A maior prevalência foi de 11,1% por HPV, seguido de 6,3% por T. vaginalis e de 4,3% por C. trachomatis. Não houve nenhum caso de N. gonorrhoeae. Para o HIV, a prevalência foi de 0,3%, e de sífilis foi de 4,3%. A citologia cervicovaginal estava alterada em 7,7%. A detecção de uma ou mais IST foi significativamente associada a idade entre 25 e 44 anos (OR = 2,33; IC95%: 1,05-5,18), a consumo de álcool (OR = 1,96; IC95%: 1,06-3,64), a resultado alterado da citologia (OR = 3,96; IC95%: 1,65-9,48) e a vaginose bacteriana (OR = 3,61; IC95%: 2,01-6,47). Em mulheres quilombolas houve elevada prevalência de uma ou mais IST, o que torna importante a elaboração de estratégias de prevenção direcionadas a essas mulheres.

Abstract: The study aimed to estimate the prevalence of sexually transmissible infections (STIs) and associated factors in women in quilombola (maroon) communities in Brazil. This was a population-based cross-sectional study of quilombola women from March 2017 to January 2019. A questionnaire was used with sociodemographic, behavioral, and clinical information. A gynecological examination was performed for the collection of uterine cervical cells for oncotic cytology and the detection of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and human papillomavirus (HPV) via polymerase chain reaction. Rapid tests for HIV and syphilis were performed. The main outcome was defined as infection with one or more sexually transmissible pathogens. The analysis used chi-square test and hierarchical logistic regression. From a total of 380 women, 352 (92.6%) were included in the study. Prevalence of at least one STI was 18.5% (95%CI: 14.76-22.85). The highest prevalence was for HPV, with 11.1%, followed by 6.3% for T. vaginalis and 4.3% for C. trachomatis. There were no cases of N. gonorrhoeae. Prevalence was 0.3% for HIV and 4.3% for syphilis. Cervical-vaginal cytology was altered in 7.7% of the women. Detection of one or more STIs was significantly associated with age 25 to 44 years (OR = 2.33; 95%CI: 1.05-5.18), alcohol consumption (OR = 1.96; 95%CI: 1.06-3.64), altered cervical cytology (OR = 3.96; 95%CI: 1.65-9.48), and bacterial vaginosis (OR = 3.61; 95%CI: 2.01-6.47). Quilombola women showed high prevalence of one or more STIs, emphasizing the importance of organizing prevention strategies targeted to these women.

Resumen: El objetivo del estudio fue estimar la prevalencia de enfermedades de transmisión sexual (ETS) y sus factores asociados en mujeres quilombolas en Brasil. Estudio transversal de base poblacional con mujeres quilombolas durante el período de marzo de 2017 a enero de 2019. Se utilizó un cuestionario con información sociodemográfica, comportamental y clínica. Se realizó un examen ginecológico, a fin de recoger células cervicales para la citología oncótica, así como para la detección de Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, y virus del papiloma humano (VPH) mediante un test de reacción en cadena de la polimerasa. Se realizó un test rápido para VIH y sífilis. El resultado principal, se definió como infección por uno o más agentes infecciosos de transmisión sexual. Para el análisis, se utilizó el test de chi-cuadrado y regresión logística jerárquica. De un total de 380 mujeres, 352 (92,6%) se incluyeron en el estudio. La prevalencia de por lo menos una ETS fue de 18,5% (IC95%: 14,76-22,85). La mayor prevalencia fue por VPH 11,1%, seguida de 6,3% por T. vaginalis y 4,3% por C. trachomatis. No hubo casos de N. gonorrhoeae. Para el VIH, la prevalencia fue de 0,3% y de sífilis fue de 4,3%. La citología cérvico-vaginal estaba alterada en un 7,7%. La detección de una o más ETS estuvo significativamente asociada con la edad entre 25 a 44 años (OR = 2,33; IC95%: 1,05-5,18), el consumo de alcohol (OR = 1,96; IC95%: 1,06-3,64), resultado alterado de la citología (OR = 3,96; IC95%: 1,65-9,48) y vaginosis bacteriana (OR = 3,61; IC95%: 2,01-6,47). Las mujeres quilombolas presentaron una elevada prevalencia por una o más ETS, por lo que es importante la elaboración de estrategias de prevención dirigidas a estas mujeres.

https://doi.org/10.1590/0102-311x00174919

Infecções sexualmente transmissíveis em mulheres afrodescendentes de comunidades quilombolas no Brasil: prevalência e fatores associados
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Dias, Jerusa Araujo

; Luciano, Thaís Verly

; Santos, Maria Carmen Lopes Ferreira Silva

; Musso, Carlos

; Zandonade, Eliana

; Spano, Liliana Cruz

; Miranda, Angelica Espinosa

Cadernos de Saúde Pública

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2021, Volume 37 N. 2 elocation e00174919

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311x00174919 1763 downloads

Giant lactating adenoma
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Moulaz, Isac Ribeiro

; Oliveira, Fernanda Sales Soares de

; Silva, Eveline Cristina da

; Machado, Janine Martins

; Santos, Maria Carmen Lopes Ferreira Silva

Autopsy and Case Reports

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2021, Volume 11 elocation e2021252

Abstract: En | Text: En | PDF: En

ABSTRACT Lactating adenoma is a rare benign breast lesion that most often presents as a small (up to 3 cm), solid, well-circumscribed, solitary, painless, mobile, lobulated mass. The highest incidence occurs in primiparous women (20 to 40 years old) during the third trimester of pregnancy. However, in the rare case presented herein, in addition to its giant size (more than 10 centimeters on palpation), this lactating adenoma is distinctive due to the presence of multiple nodules, poorly defined ultrasonographic margins, worrisome radiologic features, growth since early pregnancy, presence of infarction and association with chronic mastitis. From the clinical-radiologic perspective, the differential diagnoses included abscess associated with puerperal mastitis, phyllodes tumor, and galactocele. Biopsy was performed, and pathologic examination revealed the classic characteristics of lactating adenoma with multiple infarcted areas, leading to an unexpected confirmed case of giant lactating adenoma.

https://doi.org/10.4322/acr.2021.252 128 downloads

2021 recommendations of the Brazilian Society of Rheumatology for the gynecological and obstetric care of patients with Sjogren’s syndrome
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Oliveira, Fabiola Reis

; Valim, Valeria

; Pasoto, Sandra Gofinet

; Fernandes, Marilena Leal Mesquita Silvestre

; Lopes, Maria Lucia Lemos

; Souza Fialho, Sonia Cristina de Magalhães

; Pinheiro, Aysa César

; Santos, Laura Caldas dos

; Appenzeller, Simone

; Fidelix, Tania

; Ribeiro, Sandra Lucia Euzébio

; Brito, Danielle Christinne Soares Egypto de

; Libório, Tatiana

; Santos, Maria Carmen Lopes Ferreira Silva

; Tanure, Leandro

; Gennari, Juliana DAgostino

; Civile, Vinicius Tassoni

; Pinto, Ana Carolina Pereira Nunes

; Rocha Filho, César Ramos

; Miyamoto, Samira Tatiyama

; Guedes, Lissiane Karine Noronha

; Pugliesi, Alisson

; Trevisani, Virginia Fernandes Moça

Advances in Rheumatology

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2021, Volume 61 elocation 54

Abstract: En | Text: En | PDF: En

Abstract Sjogren’s syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs. Women with SS often experience gynecological symptoms due to the disease and need extra care regarding their sexual activity, reproductive health and during pregnancy, conditions that are not properly conducted in the clinical practice. To cover this gap, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of symptoms, diagnosis, monitoring, prognosis, and treatment of these manifestations. A Focus Group meeting was held and included experts in the field and methodologists, based on a previously developed script, with themes related to the objective of the study. The most important topics were summarized and 11 recommendations were provided.

https://doi.org/10.1186/s42358-021-00208-1 54 downloads

Recommendations from the Brazilian society of rheumatology for the diagnosis of Sjögren's syndrome (Part I): glandular manifestations (systematic review)
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Trevisani, Virginia Fernandes Moça

; Pasoto, Sandra Gofinet

; Fernandes, Marilena Leal Mesquita Silvestre

; Lopes, Maria Lucia Lemos

; Fialho, Sonia Cristina de Magalhães Souza

; Pinheiro, Aysa César

; Santos, Laura Caldas dos

; Appenzeller, Simone

; Fidelix, Tania

; Ribeiro, Sandra Lucia Euzébio

; Brito, Danielle Christinne Soares Egypto de

; Libório, Tatiana

; Santos, Maria Carmen Lopes Ferreira Silva

; Tanure, Leandro

; Gennari, Juliana D Agostino

; Civile, Vinicius Tassoni

; Pinto, Ana Carolina Pereira Nunes

; Oliveira, Fabiola Reis

; Sousa, Jaqueline Martins de

; Miyamoto, Samira Tatiyama

; Valim, Valeria

Advances in Rheumatology

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2019, Volume 59 elocation 58

Abstract: En | Text: En | PDF: En

Abstract Background: Primary Sjögren's syndrome (pSS) is a systemic immune-mediated disease whose main characteristic is exocrine gland inflammation and, subsequent reduction in tear and saliva production. A delayed diagnosis is common due to the nonspecific clinical manifestations of disease. The aim of the present study was to develop recommendations for the diagnosis of glandular manifestations of pSS based on evidence and expert opinion. Main body of the abstract: We conducted a systematic literature review to retrieve the best evidence available on the accuracy of diagnostic tests for pSS. We also held two in-person meetings with experts (rheumatologists, pathologists, ophthalmologists and dentists) to establish their level of agreement using the Delphi method. Ultimately, we generated 18 recommendations that aim to facilitate the diagnosis of the glandular manifestations of pSS. Conclusion: The diagnosis of glandular manifestations of pSS is complex and multidisciplinary. It requires specific knowledge in the field of ophthalmology, immunology, pathology and imaging, making it compulsory for the rheumatologist to work with professionals from these different areas in order to improve accuracy and early diagnosis. Glandular dysfunction tests, ANA, RF, Anti-Ro, protein electrophoresis, urinalysis, blood count, C-Reactive protein, complement, testing for syphilis and viruses (HCV, HIV) and SGUS should be investigated when dryness or systemic manifestation are present. Minor salivary gland biopsy is recommended for all anti-Ro negative or incomplete criteria cases.

https://doi.org/10.1186/s42358-019-0102-8 878 downloads

Validação e propriedades psicométricas do Eular Sjögren's Syndrome Patient Reported Index (ESSPRI) para a língua portuguesa
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Paganotti, Maurício Aquino

; Valim, Valéria

; Serrano, Érica Vieira

; Miyamoto, Samira Tatiyama

; Giovelli, Raquel Altoé

; Santos, Maria Carmen Lopes Ferreira Silva

Revista Brasileira de Reumatologia

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oct 2015, Volume 55 N. 5 Pages 439 - 445

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMOObjetivo:Fazer a adaptação transcultural do Eular Sjögren's Syndrome Patient Reported Index (ESSPRI) para a língua portuguesa e avaliar as suas propriedades psicométricas.Método:Estudo transversal de pacientes com síndrome de Sjögren primária (SS). Foram estudadas as propriedades psicométricas (reprodutibilidade intraobservador e a validade de construto). Na validade de construto, o ESSPRI foi comparado com o Patient's Global Assessment (PaGA), Profile of Fatigue and Discomfort (Profad), Sicca Symptoms Inventory (SSI) e Functional Assessment of Chronic Illness Therapy (Facit-fatigue). Os testes estatísticos usados foram o α-Cronbach, coeficiente de correlação intraclasse (CCI), método de Bland-Altman e coeficiente de Spearman. Foi considerado significativo o p ≤ 0,05.Resultados:Não houve diferença entre as versões nas duas línguas e obteve-se, assim, a versão consensual brasileira. Todos os indivíduos foram mulheres de 49,4 ± 11,6 anos, com início dos sintomas de 7,2 ± 5,4 anos e tempo de diagnóstico de 3 ± 3,3 anos. A média do ESSPRI foi de 6,87 ± 1,97. A reprodutibilidade intraobservador foi alta e significativa (0,911) e, no método de Bland-Altman, não houve viés sistemático na concordância das medidas entre as avaliações. Houve correlação moderada do ESSPRI com todos os instrumentos testados.Conclusão:A versão do ESSPRI em português é válida e reprodutível.

ABSTRACTObjective:To carry out the cross-cultural adaptation of EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI) for Portuguese language and evaluate its psychometric properties.Method:Cross-secal study of patients with primary Sjögren's syndrome (SS). The psychometric properties (intraobserver reproducibility and construct validity) were studied. In construct validity, ESSPRI was compared with the Patient's Global Assessment (PGA), Profile of Fatigue and Discomfort (Profad), Sicca Symptoms Inventory (SSI) and Functional Assessment of Chronic Illness Therapy (Facit-F). Statistical tests used were: Cronbach's alpha, intraclass correlation coefficient (ICC), Bland-Altman method and Spearman coefficient. A value of p ≤ 0.05 was considered significant.Results:There was no difference between versions in both languages; thus, a Brazilian consensual version was obtained. All subjects were women aged 49.4 ± 11.6 years, with onset of symptoms of 7.2 ± 5.4 years, and time of diagnosis of 3.0 ± 3.3 years. The mean ESSPRI was 6.87 ± 1.97. The intraobserver reproducibility was high and significant (0.911) and, with Bland-Altman method, there was no systematic bias in the agreement of measures among evaluations. A moderate correlation of ESSPRI with all tested instruments was observed.Conclusion:The Brazilian Portuguese version of ESSPRI is a valid and reproducible version.

https://doi.org/10.1016/j.rbr.2015.06.004 5446 downloads

10.

Recomendações para o tratamento da síndrome de Sjögren
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Valim, Valéria

; Trevisani, Virgínia Fernandes Moça

; Pasoto, Sandra Gofinet

; Serrano, Erica Vieira

; Ribeiro, Sandra Lúcia Euzébio

; Fidelix, Tania Sales de Alencar

; Vilela, Verônica Silva

; Prado, Leandro Lara do

; Tanure, Leandro Augusto

; Libório-Kimura, Tatiana Nayara

; Brito Filho, Odvaldo Honor de

; Barros, Liliana Aparecida Pimenta de

; Miyamoto, Samira Tatiyama

; Lourenço, Silvia Vanessa

; Santos, Maria Carmen Lopes Ferreira Silva

; Vieira, Luis Antonio

; Adán, Consuelo Bueno Diniz

; Bernardo, Wanderley Marques

Revista Brasileira de Reumatologia

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oct 2015, Volume 55 N. 5 Pages 446 - 457

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMOAs recomendações propostas pela Comissão de Síndrome de Sjögren da Sociedade Brasileira de Reumatologia para tratamento da síndrome de Sjögren foram baseadas em uma revisão sistemática da literatura nas bases de dados Medline (PubMed) e Cochrane até outubro de 2014 e opinião de especialistas na ausência de artigos sobre o assunto. Foram incluídos 131 artigos classificados de acordo com Oxford & Grade. Essas recomendações foram elaboradas com o objetivo de orientar o manejo adequado e facilitar o acesso aos tratamentos para aqueles pacientes com adequada indicação de recebê-los, considerando o contexto socioeconômico brasileiro e os medicamentos disponíveis no país.

ABSTRACTThe recommendations proposed by the Sjögren's Syndrome Committee of the Brazilian Society of Rheumatology for the treatment of Sjögren's syndrome were based on a systematic review of literature in Medline (PubMed) and the Cochrane databases until October 2014 and on expert opinion in the absence of studies on the subject. 131 articles classified according to Oxford & Grade were included. These recommendations were developed in order to guide the management and facilitate the access to treatment for those patients with an appropriate indication, considering the Brazilian socioeconomic context and pharmacological agents available in this country.

https://doi.org/10.1016/j.rbr.2015.07.004 60323 downloads

11.

Correlação entre níveis de iodo na urina e alterações anatomopatológicas em tireoide
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Boasquevisque, Paulo César Ribeiro

; Jarske, Robson Dettman

; Dias, Cleia Coelho

; Quintaes, Isabela Passos Pereira

; Santos, Maria Carmen Lopes Ferreira Silva

; Musso, Carlos

Arquivos Brasileiros de Endocrinologia & Metabologia

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dec 2013, Volume 57 N. 9 Pages 727 - 732

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVOS: Determinar o aporte nutricional de iodo na população estudada e correlacionar os níveis de iodo encontrados em amostras casuais de urina (iodúria) com alterações anatomopatológicas observadas nas tireoides dessa população. MATERIAIS E MÉTODOS: Determinou-se a iodúria em 30 amostras casuais de urina e realizou-se o estudo anatomopatológico de 55 tireoides colhidas de cadáveres que deram entrada no Departamento Médico Legal de Vitória, Espírito Santo, Brasil, no período de maio a agosto de 2011. RESULTADOS: Em 29 amostras de urina (96,7%) encontrou-se iodúria acima do limite máximo preconizado pela Organização Mundial da Saúde (OMS) de 300 µg/L. Em 14 tireoides (25,5%) foi identificada a presença de quadros histológicos compatíveis com tireoidite. Níveis mais elevados de iodo na urina foram observados no sexo feminino e nos casos de tireoides com presença de achados inflamatórios (tireoidites). CONCLUSÕES: Podemos concluir que na população estudada houve um excesso de iodo em seu aporte nutricional e uma maior incidência de quadros inflamatórios tireoidianos.

OBJECTIVES: To determine iodine nutrition in the population and to correlate levels of iodine found in random samples of urine with pathological changes observed in thyroids collected in this population. MATERIALS AND METHODS: Urinary iodine was determined in 30 random samples of urine and the pathological study was carried out in 55 thyroid glands from corpses received by the Department of Forensic Medicine of Vitória, Espírito Santo, Brazil from May to August 2011. RESULTS: In 29 urine samples (96.7%) urinary iodine was above the maximum limit recommended by the World Health Organization (WHO), of 300 mg/L. Fourteen thyroids (25.5%) showed the presence of histological changes compatible with thyroiditis. Higher levels of iodine in urine were observed in females and in of thyroid that showed inflammation (thyroiditis). CONCLUSIONS: We conclude that, in this population, there is excess iodine intake, and greater incidence of inflammatory thyroid disease.

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Glossary and search help

You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.

For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

See below the complete list of search indexes that can be used:

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

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