Abstract Introduction: Experience with endoscopic retrograde cholangiopancreatography (ERCP) in the pediatric population is limited. Few medical centers have experts specifically trained in pediatric therapeutic endoscopy. As a result, patients are generally referred to adult endoscopists with high experience in the procedure. The aim of this study was to characterize the experience of an adult endoscopy unit with ERCP on pediatric patients, with a special focus on very young patients. Methods: We retrospectively analyzed indications, technical success rate, final clinical diagnosis, and complica-tions of ERCPs in children <18 years at our tertiary referral hospital center between January 1994 and June 2022. Results: Sixty-five ERCPs were performed on 57 children with a median age of 13 years (range 1-17 years). Eleven ERCPs were performed on 9 patients up to 5 years old. Indications for ERCP were as follows: biliary obstruction (n = 40), mainly due to choledocholithiasis, lithiasic acute pancreatitis (n = 19), recurrent pancreatitis (n = 3), stent extraction (n = 2), and post-operative biliary fistula (n = 1). The cannulation success rate was 95.1%. Therapeutic interventions were performed in 79% of ERCP. All patients were followed up as inpatients. Complications were recorded in two procedures (3.1%), and no procedure-related mortality occurred. Conclusion: In our experience, ERCP in children can be safely performed with high success rates by advanced adult-trained expert endoscopists at a high-volume center.

Resumo Introdução: Existe pouca experiência na realização de colangiopancreatografia retrógrada endoscópica (CPRE) na população pediátrica. A maioria dos centros carece de especialistas especificamente treinados em endoscopia terapêutica pediátrica, sendo os doentes geralmente referenciados para Gastroenterologistas de adultos com elevada experiência na técnica. O objectivo deste estudo foi caracterizar a experiência de um departamento de Gastrenterologia de adultos em CPRE pediátrica, com destaque particular nos doentes muito novos. Métodos: Foram analisadas retrospectivamente as indicações, sucesso técnico, diagnósticos e complicações das colan-giopancreatografias retrógradas endoscópicas (CPREs) realizadas no nosso hospital terciário em crianças <18 anos, entre Janeiro de 1994 e Junho de 2022. Resultados: Foram realizadas 65 CPREs em 57 crianças com idade mediana 13 anos (1-17 anos). Doze procedimentos foram realizados em 9 crianças com idade até 5 anos. As indicações para CPRE foram: obstrução biliar (n = 40), sobretudo devido a coledocolitíase, pancreatite aguda litiásica (n = 19), pancreatite recorrente (n = 3), extracção de prótese (n = 2) e fístula biliar pós cirurgia (n = 1). A taxa de sucesso de canulação foi 95.4%. Foram realizados procedimentos terapêuticos em 80.0% das CPREs. Todos os doentes foram vigiados em regime de internamento, tendo-se registado complicações em dois exames (3.1%). Não existiram mortes relacionadas com a técnica. Discussão/Conclusão: A CPRE pode ser realizada na população pediátrica com segurança e elevada taxa de sucesso por Gastrenterologistas de adultos com experiência na técnica, num centro com elevado volume de exames.

RÉSUMÉ L’article présente et analyse l’histoire et les liens de différentes expériences de commerce du livre à São Paulo, Minas Gerais et Rio de Janeiro, entre 1972 et 2018, à savoir : Livraria Contexto, Livraria Eboh, Livraria Griot, Sobá Livraria e Café, Kitabu Livraria Negra , Iná Livros et Livraria Africanidades. Des librairies spécifiquement noires, avec des propriétaires noirs, dédiées à la littérature en circulation produite et éditée par des auteurs noirs et/ou africains. Parfois, avec des liens avec des associations et des mouvements noirs contemporains. Compte tenu de la rareté des recherches sur cet objet spécifique, la principale méthode utilisée a été l’entretien structuré avec les sujets impliqués dans l’activité, l’analyse des sources secondaires, ainsi que l’utilisation de la recherche dans les journaux, qui s’est avérée très importante pour comprendre certaines des les significations sociales attribuées par les commerçants noirs à leur activité, leur portée, leurs liens de sens et limites. Larticle L article lhistoire l histoire Paulo Janeiro 197 2018 Contexto Eboh Griot Café Africanidades noires etou ou africains Parfois contemporains spécifique lentretien entretien lactivité, lactivité activité l’activité lanalyse secondaires lutilisation utilisation journaux sest s est portée limites 19 201 1 20 2

RESUMEN El artículo presenta y analiza la historia y las conexiones de diferentes experiencias de comercio de libros en São Paulo, Minas Gerais y Rio de Janeiro, entre 1972 y 2018, a saber: Livraria Contexto, Livraria Eboh, Livraria Griot, Sobá Livraria e Café, Kitabu Livraria Negra, Iná Livros, Livraria Africanidades . Estas son, específicamente, librerías negras, de propietarias negras y dueños negros, que se dedicaron a hacer circular la literatura producida y editada por autoría negra y/o africana. En ocasiones, estas librerías han tenido conexiones con asociaciones y movimientos negros coetáneos. Considerando la escasez de investigaciones sobre este objeto de estudio en específico, fue utilizado como método principal la entrevista estructurada con los sujetos involucrados en esta actividad, el análisis de fuentes secundarias, así como la investigación en periódicos, que se reveló bastante importante para comprender algunos de los sentidos sociales atribuidos por los comerciantes negros a su actividad, sus alcances, conexiones de sentidos y límites. Paulo Janeiro 197 2018 saber Contexto Eboh Griot Café Negra Livros son específicamente yo o africana ocasiones coetáneos específico actividad secundarias periódicos alcances límites 19 201 1 20 2

ABSTRACT This article presents and analyzes the history and connections among various black bookstore experiences in Southeast Brazil between 1972 and 2018. Given the lack of research on the topic in Brazil, this study relies heavily on structured interviews with some of the individuals in the sector, as well as on the analysis of secondary data and news. The stores studied are Livraria Contexto, Livraria Eboh, Livraria Griot, Sobá Livraria e Café, Kitabu Livraria Negra, Iná Livros and Livraria Africanidades, located in the states of São Paulo, Minas Gerais and Rio de Janeiro. They are owned by black women and men devoted to selling black and African literature, some of whom have been activists in different segments of Brazil’s black movements. Our findings have advanced a deeper understanding of the social meanings black traders assign to their activity, their reach, the connections among their purposes, and their limitations. 197 2018 sector news Contexto Eboh Griot Café Negra Africanidades Paulo Janeiro literature Brazils s movements activity reach purposes limitations 19 201 1 20 2

RESUMO O artigo apresenta e analisa a história e as conexões de diferentes experiências de comércio livreiro em São Paulo, Minas Gerais e Rio de Janeiro, entre 1972 e 2018, a saber: Livraria Contexto, Livraria Eboh, Livraria Griot, Sobá Livraria e Café, Kitabu Livraria Negra, Iná Livros, Livraria Africanidades. Especificamente livrarias negras, de proprietárias negras e donos negros, que se dedicaram a fazer circular a literatura produzida e editada pela autoria negra e/ou africana. Por vezes, com conexões com associações e movimentos negros coetâneos. Considerando a escassez de pesquisas sobre este objeto específico, foi utilizado como método principal a entrevista estruturada com os sujeitos envolvidos na atividade, análise de fontes secundárias bem como o recurso a pesquisa em jornais, que se revelou bastante importante para compreender alguns dos sentidos sociais atribuídos pelos comerciantes negros em sua atividade, seus alcances, conexões de sentidos e limites. Paulo Janeiro 197 2018 saber Contexto Eboh Griot Café Negra Livros Africanidades eou ou africana vezes coetâneos específico atividade jornais alcances limites 19 201 1 20 2

ABSTRACT Brazil has been suffering a dengue (DENV) epidemic in 2019 and 2022 and records cases of Zika (ZIKV) and chikungunya (CHIKV). Londrina city, Paraná, stands out for the number of cases and deaths from dengue. Therefore, this study aimed to verify the density and diversity of mosquitoes present in urban public establishments of Londrina, to analyze their ecological relationships, and to investigate the presence of the DENV, ZIKV, and CHIKV. Ovitraps were installed in outdoor sites in two public establishments in each region of Londrina, while adult culicids were caught indoors with a Nasci aspirator. A total of 5077 eggs were obtained in 77 ovitraps. The South region had the highest infestation while the East had the lowest (Ovitrap Positivity Index: 38% and 25%; Egg Density Index: 67.83 and 19.03, respectively). From eggs, 704 Aedes aegypti females and 71 Aedes albopictus females were obtained, while in the aspiration of adults, 99 A. aegypti and 11 Culex quinquefasciatus were captured, the highest number in the West and the lowest in the North. The DENV-II virus was detected in a pool of 17 A. aegypti females in the West region. The results demonstrate high density of pathogen vector species, mainly A. aegypti, in and around establishments, alerting to the need for constant local entomological surveillance to prevent viral circulation, mainly in crowded places. The presence of A. albopictus around the establishments also alerts to the urbanization of the species and potential participation in the viral circulation, demonstrating the need for constant monitoring. DENV (DENV 201 202 ZIKV (ZIKV CHIKV . (CHIKV) city Paraná Therefore relationships aspirator 507 7 ovitraps Ovitrap Index 38 25% 25 6783 67 83 67.8 1903 19 03 19.03 respectively. respectively respectively) 70 adults 9 1 captured North DENVII II circulation places monitoring 20 (CHIKV 50 3 2 678 6 8 67. 190 0 19.0 5 19.

ABSTRACT Background: Alcoholic liver disease (ALD) and metabolic-dysfunction associated steatotic liver disease (MASLD) are common, and gut microbiota (GM) is involved with both. Here we compared GM composition in animal models of MASLD and ALD to assess whether there are specific patterns for each disease. Methods: MASLD model- adult male Sprague Dawley rats, randomized into two groups: MASLD-control (n=10) fed a standard diet; MASLD-group (n=10) fed a high-fat-choline-deficient diet for 16 weeks. ALD model- adult male Wistar rats randomized: ALD-control (n=8) fed a standard diet and water+0.05% saccharin, ALD groups fed with sunflower seed and 10% ethanol+0.05% saccharin for 4 or 8 weeks (ALC4, n=8; ALC8, n=8). ALC4/8 on the last day received alcoholic binge (5g/kg of ethanol). Afterwards, animals were euthanized, and feces were collected for GM analysis. Results: Both experimental models induced typical histopathological features of the diseases. Alpha diversity was lower in MASLD compared with ALD (p<0.001), and structural pattern was different between them (P<0.001). Bacteroidetes (55.7%), Firmicutes (40.6%), and Proteobacteria (1.4%) were the most prevalent phyla in all samples, although differentially abundant among groups. ALC8 had a greater abundance of the phyla Cyanobacteria (5.3%) and Verrucomicrobiota (3.2%) in relation to the others. Differential abundance analysis identified Lactobacillaceae_unclassified, Lachnospiraceae_NK4A136_group, and Turicibacter associated with ALC4 and the Clostridia_UCG_014_ge and Gastranaerophilales_ge genera to ALC8. Conclusion: In this study, we demonstrated that the structural pattern of the GM differs significantly between MASLD and ALD models. Studies are needed to characterize the microbiota and metabolome in both clinical conditions to find new therapeutic strategies. Background (ALD metabolicdysfunction metabolic dysfunction (MASLD common (GM Methods model MASLDcontrol control n=10 n10 n 10 (n=10 MASLDgroup group highfatcholinedeficient high fat choline deficient 1 ALDcontrol n=8 n8 (n=8 water005 water 0 05 water+0.05 ethanol005 ethanol ethanol+0.05 ALC4, ALC (ALC4 n=8. . n=8) ALC48 ALC4/ 5g/kg 5gkg gkg 5g kg g ethanol. ethanol) Afterwards euthanized Results diseases p<0.001, p0001 p p<0.001 , 001 (p<0.001) P<0.001. P0001 P P<0.001 (P<0.001) 55.7%, 557 55.7% 55 7 (55.7%) 40.6%, 406 40.6% 40 6 (40.6%) 1.4% 14 (1.4% samples 5.3% 53 5 3 (5.3% 3.2% 32 2 (3.2% others Lactobacillaceaeunclassified Lactobacillaceae unclassified Lactobacillaceae_unclassified LachnospiraceaeNK4A136group LachnospiraceaeNKAgroup Lachnospiraceae NK4A136 NK A Lachnospiraceae_NK4A136_group ClostridiaUCG014ge ClostridiaUCGge Clostridia UCG 014 ge Gastranaerophilalesge Gastranaerophilales Conclusion study strategies n=1 n1 (n=1 n= (n= water00 water+0.0 ethanol00 ethanol+0.0 (ALC p000 p<0.00 00 (p<0.001 P000 P<0.00 (P<0.001 55.7 (55.7% 40.6 (40.6% 1.4 (1.4 5.3 (5.3 3.2 (3.2 LachnospiraceaeNK NKA NK4A13 ClostridiaUCG 01 (n water0 water+0. ethanol0 ethanol+0. p00 p<0.0 (p<0.00 P00 P<0.0 (P<0.00 55. (55.7 40. (40.6 1. (1. 5. (5. 3. (3. NK4A1 water+0 ethanol+0 p0 p<0. (p<0.0 P0 P<0. (P<0.0 (55. (40. (1 (5 (3 NK4A water+ ethanol+ p<0 (p<0. P<0 (P<0. (55 (40 ( p< (p<0 P< (P<0 (4 (p< (P< (p (P

RESUMO Contexto: A doença hepática alcoólica (DHA) e a doença hepática esteatótica associada à disfunção metabólica (MASLD) são comuns, e a microbiota intestinal (MI) está envolvida em ambas. Aqui, comparamos a composição da MI em modelos animais de MASLD e DHA para avaliar se existem padrões específicos para cada doença. Métodos: Modelo de MASLD - ratos machos adultos da linhagem Sprague Dawley, randomizados em dois grupos: MASLD-controle (n=10) alimentados com uma dieta padrão; grupo MASLD (n=10) alimentados com uma dieta rica em gordura e deficiente em colina por 16 semanas. Modelo de DHA - ratos machos adultos da linhagem Wistar randomizados: DHA-controle (n=8) alimentados com uma dieta padrão e água+0,05% de sacarina; grupos DHA alimentados com semente de girassol e 10% de etanol+0,05% de sacarina por 4 ou 8 semanas (DHA4, n=8; DHA8, n=8). DHA 4/8 no último dia receberam binge alcoólico (5 g/kg de etanol). Posteriormente, os animais foram sacrificados, e as fezes foram coletadas para análise da MI. Resultados: Ambos os modelos experimentais induziram características histopatológicas típicas das doenças. A diversidade alfa foi menor na MASLD em comparação com a DHA (P<0,001), e o padrão estrutural foi diferente entre elas (P<0,001). Bacteroidetes (55,7%), Firmicutes (40,6%) e Proteobactérias (1,4%) foram os filos mais prevalentes em todas as amostras, embora com abundâncias diferenciadas entre os grupos. DHA8 teve uma maior abundância dos filos Cyanobacteria (5,3%) e Verrucomicrobiota (3,2%) em relação aos outros. A análise de abundância diferencial identificou Lactobacillaceae_unclassified, Lachnospiraceae_NK4A136 e Turicibacter associados ao grupo DHA4, e os gêneros Clostridia_UCG_014_ge e Gastranaerophilales_ge associados ao DHA8. Conclusão: Neste estudo, demonstramos que o padrão estrutural da MI difere significativamente entre os modelos de MASLD e DHA. Estudos são necessários para caracterizar a microbiota e os metabólitos ativos em ambas as condições clínicas, a fim de encontrar novas estratégias terapêuticas. Contexto (DHA (MASLD comuns (MI Aqui Métodos Dawley MASLDcontrole controle n=10 n10 n 10 (n=10 1 DHAcontrole n=8 n8 (n=8 água005 água 0 05 água+0,05 etanol005 etanol etanol+0,05 DHA4 (DHA4 n=8. . n=8) 48 4/ 5 ( gkg g kg etanol. etanol) Posteriormente sacrificados Resultados doenças P<0,001, P0001 P P<0,001 , 001 (P<0,001) P<0,001. 55,7%, 557 55,7% 55 7 (55,7%) 40,6% 406 40 6 (40,6% 1,4% 14 (1,4% amostras 5,3% 53 3 (5,3% 3,2% 32 2 (3,2% outros Lactobacillaceaeunclassified Lactobacillaceae unclassified Lactobacillaceae_unclassified LachnospiraceaeNK4A136 LachnospiraceaeNKA Lachnospiraceae NK4A136 NK Lachnospiraceae_NK4A13 ClostridiaUCG014ge ClostridiaUCGge Clostridia UCG 014 ge Gastranaerophilalesge Gastranaerophilales Conclusão estudo clínicas terapêuticas n=1 n1 (n=1 n= (n= água00 água+0,0 etanol00 etanol+0,0 P000 P<0,00 00 (P<0,001 55,7 (55,7% 40,6 (40,6 1,4 (1,4 5,3 (5,3 3,2 (3,2 LachnospiraceaeNK LachnospiraceaeNK4A13 NKA NK4A13 Lachnospiraceae_NK4A1 ClostridiaUCG 01 (n água0 água+0, etanol0 etanol+0, P00 P<0,0 (P<0,00 55, (55,7 40, (40, 1, (1, 5, (5, 3, (3, LachnospiraceaeNK4A1 NK4A1 Lachnospiraceae_NK4A água+0 etanol+0 P0 P<0, (P<0,0 (55, (40 (1 (3 LachnospiraceaeNK4A NK4A água+ etanol+ P<0 (P<0, (55 (4 P< (P<0 (P< (P

Abstract Introduction: The coronavirus (COVID-19) pandemic in higher education has had disturbing consequences on the lives and mental health of students. We intend to evaluate the levels of anxiety, depression, and stress of nursing students at the Polytechnic Institute of Santarem. Method: Exploratory, observational, descriptive, and correlational study. Students: 183 students, selected by convenience sampling. Measurement instrument: Anxiety, Depression and Stress Scale - EADS-21 validated for the Portuguese population, applied between November 19 and December 4, 2020. The collected data were analyzed using the IBM SPSS Statistics for Windows Software, version 27.0. Conclusions: The findings showed that most students had a normal level of depression (82.5%), anxiety (88.0%) and stress (94.0%). About 1.6% of students reported a moderate level of stress; 5.5% and 1.6% a moderate and severe level, respectively, of anxiety and 6% and 0.5% depression a moderate and severe level, in due order. Significant differences were found between means (Student's t test) in the comparison between gender (p < 0.001), with the highest scores, in the three dimensions, in the female gender that presented more stress (M = 7.59 + 4.728), depression (M = 5.83 + 4.503) and anxiety (M =3.87 + 3.869), that is, the affective states of the female gender were more negative.

Resumen Introducción: La pandemia del coronavirus (COVID-19) en la educación superior ha tenido consecuencias preocupantes en la vida y salud mental de los estudiantes. Pretendemos evaluar los niveles de ansiedad, depresión y estrés de estudiantes de enfermería del Instituto Politécnico de Santarém. Método: Estudio exploratorio, observacional, descriptivo y correlacional. Estudiantes: 183 estudiantes, seleccionados por muestreo por conveniencia. Instrumento de medición: Escala de Ansiedad, Depresión y Estrés - EADS-21 validada para la población portuguesa, aplicada entre el 19 de noviembre y el 4 de diciembre de 2020. Los datos recolectados fueron analizados utilizando el software IBM SPSS Statistics para Windows, versión 27.0. Conclusiones: Los hallazgos mostraron que la mayoría de los estudiantes presentaba un nivel normal de depresión (82,5%), ansiedad (88,0%) y estrés (94,0%). Alrededor del 1,6% de los estudiantes reportaron un nivel moderado de estrés; 5,5% y 1,6% un nivel moderado y severo, respectivamente, de ansiedad y 6% y 0,5% depresión un nivel moderado y severo, en su debido orden. Se encontraron diferencias significativas entre las medias (prueba t de Student) en la comparación entre género (p < 0,001), con las puntuaciones más altas, en las tres dimensiones, en el género femenino que presentó más estrés (M = 7,59 + 4,728), depresión (M = 5,83 + 4,503) y ansiedad (M =3,87 + 3,869), es decir, los estados afectivos del género femenino fueron más negativos.

Resumo Introdução: A pandemia do coronavírus (COVID-19) no ensino superior causou consequências perturbadoras na vida e na saúde mental dos estudantes. Pretendemos avaliar os níveis de ansiedade, depressão e stress dos estudantes de enfermagem do Instituto Politécnico de Santarém. Método: Estudo exploratório, observacional descritivo e correlacional. Estudantes: 183 estudantes, selecionados por amostragem de conveniência. Instrumento de medida: Escala de Ansiedade, Depressão e Stress - EADS-21 validada para a população portuguesa, aplicada entre 19 de novembro e 4 de dezembro de 2020. Os dados recolhidos foram analisados com o Software IBM SPSS Statistics for Windows, versão 27.0. Conclusões: Os achados mostraram que a maioria dos estudantes apresentou um nível normal de depressão (82,5%), ansiedade (88,0%) e stress (94,0%). Cerca de 1,6% dos estudantes relataram nível moderado de stress; 5,5% e 1,6% um nível moderado e grave, respetivamente, de ansiedade e 6% e 0,5% depressão um nível moderado e grave, na devida ordem. Foram encontradas diferenças significativas entre as médias (teste t de Student) na comparação entre género (p < 0,001), com os maiores scores, nas três dimensões, no género feminino que apresentou mais stress (M = 7,59 + 4,728), depressão (M = 5,83 + 4,503) e ansiedade (M =3,87 + 3,869), ou seja, os estados afetivos do género feminino foram mais negativos.

ABSTRACT Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality worldwide. The Brazilian Society of Hepatology (SBH) published in 2020 the updated recommendations for the diagnosis and treatment of HCC. Since then, new data have emerged in the literature, including new drugs approved for the systemic treatment of HCC that were not available at the time. The SBH board conducted an online single-topic meeting to discuss and review the recommendations on the systemic treatment of HCC. The invited experts were asked to conduct a systematic review of the literature on each topic related to systemic treatment and to present the summary data and recommendations during the meeting. All panelists gathered together for discussion of the topics and elaboration of the updated recommendations. The present document is the final version of the reviewed manuscript containing the recommendations of SBH and its aim is to assist healthcare professionals, policy-makers, and planners in Brazil and Latin America with systemic treatment decision-making of patients with HCC. (HCC cancerrelated cancer worldwide (SBH 202 then time singletopic single professionals policymakers, policymakers policy makers, makers policy-makers decisionmaking decision making 20 2

RESUMO O carcinoma hepatocelular (CHC) é uma das principais causas de mortalidade relacionada a câncer no Brasil e no mundo. A Sociedade Brasileira de Hepatologia (SBH) publicou em 2020 a atualização das recomendações da SBH para o diagnóstico e tratamento do CHC. Desde então, novas evidências científicas sobre o tratamento sistêmico do CHC foram relatadas na literatura médica, incluindo novos medicamentos aprovados que não estavam disponíveis na época do último consenso, levando a diretoria da SBH a promover uma reunião monotemática on-line para discutir e rever as recomendações sobre o tratamento sistêmico do CHC. Um grupo de experts foi convidado para realizar uma revisão sistemática da literatura e apresentar uma atualização, baseada em evidências científicas, sobre cada tópico relacionado ao tratamento sistêmico e a apresentar os dados e recomendações resumidas durante a reunião. Todos os painelistas se reuniram para discutir os tópicos e elaborar as recomendações atualizadas. O presente documento é a versão final do manuscrito revisado, contendo as recomendações da SBH, e seu objetivo é auxiliar os profissionais de saúde, formuladores de políticas e planejadores no Brasil e na América Latina na tomada de decisões sobre o tratamento sistêmico de pacientes com CHC. (CHC mundo (SBH 202 então médica consenso online on line atualizadas revisado saúde 20 2

Abstract Hemodynamic forces are related to pathological variations of the cardiovascular system, and numerical simulations for fluid-structure interaction have been systematically used to analyze the behavior of blood flow and the arterial wall in aortic aneurysms. This paper proposes a comparative analysis of 1-way and 2-way coupled fluid-structure interaction for aortic arch aneurysm. The coupling models of fluid-structure interaction were conducted using 3D geometry of the thoracic aorta from computed tomography. Hyperelastic anisotropic properties were estimated for the Holzapfel arterial wall model. The rheological behavior of the blood was modeled by the Carreau-Yasuda model. The results showed that the 1-way approach tends to underestimate von Mises stress, displacement, and strain over the entire cardiac cycle, compared to the 2-way approach. In contrast, the behavior of the variables of flow field, velocity, wall shear stress, and Reynolds number when coupled by the 1-way model was overestimated at the systolic moment and tends to be equal at the diastolic moment. The quantitative differences found, especially during the systole, suggest the use of 2-way coupling in numerical simulations of aortic arch aneurysms due to the hyperelastic nature of the arterial wall, which leads to a strong iteration between the fluid and the arterial wall. system fluidstructure structure 1way way 1 2way 2 aneurysm D tomography CarreauYasuda Carreau Yasuda stress displacement cycle contrast field velocity found systole

ABSTRACT Aedes (Stegomyia) aegypti is an important vector of dengue, yellow fever, chikungunya and Zika virus. It is well known that resistance monitoring and genetic diversity data help designing the vector control programs. This study aimed to evaluate resistance to pyrethroids (PYs) through the frequency of kdr mutations Val1016IIe and F1534C, and the genetic variation of the mitochondrial gene ND4 in six natural populations of A. aegypti from Paraná - Brazil. Adults were obtained from eggs collected from Alvorada do Sul, Marilena, Maringá, Nova Londrina, Paranavaí and São Carlos do Ivaí. From these adults, 345 were used to identify the 1016 and 1534 sites, and 120 were used to perform the ND4 gene analysis. The studied populations from Paraná showed PYs resistance, low gene flow and genetic diversity. Additionally, a relationship was observed among the haplotypes of populations from the Amazon and Southeastern Brazil, Peru, Mexico, and North America. Stegomyia (Stegomyia dengue fever virus programs (PYs ValIIe Val IIe F1534C FC F C ND A Brazil Sul Marilena Maringá Londrina Ivaí adults 34 101 153 sites 12 analysis Additionally Peru Mexico America 3 10 15 1

ABSTRACT Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as Nonalcoholic fatty liver disease (NAFLD), is one of the most common hepatic diseases in individuals with overweight or obesity. In this context, a panel of experts from three medical societies was organized to develop an evidence-based guideline on the screening, diagnosis, treatment, and follow-up of MASLD. Material and methods: A MEDLINE search was performed to identify randomized clinical trials, meta-analyses, cohort studies, observational studies, and other relevant studies on NAFLD. In the absence of studies on a certain topic or when the quality of the study was not adequate, the opinion of experts was adopted. Classes of Recommendation and Levels of Evidence were determined using prespecified criteria. Results: Based on the literature review, 48 specific recommendations were elaborated, including 11 on screening and diagnosis, 9 on follow-up, 14 on nonpharmacologic treatment, and 14 on pharmacologic and surgical treatment. Conclusions: A literature search allowed the development of evidence-based guidelines on the screening, diagnosis, treatment, and follow-up of MASLD in individuals with overweight or obesity. Introduction dysfunctionassociated dysfunction associated MASLD, , (MASLD) NAFLD, NAFLD (NAFLD) obesity context evidencebased evidence based diagnosis treatment followup follow up methods trials metaanalyses, metaanalyses meta analyses, analyses meta-analyses adequate adopted criteria Results review 4 elaborated 1 followup, up, Conclusions (MASLD (NAFLD

Resumo Introdução A avaliação da satisfação de usuários no serviço de saúde bucal tem sua relevância enquanto medida de efeito da atenção à saúde, sobre os aspectos biopsicossociais dos usuários, contudo são escassos os estudos de revisão de literatura sobre o tema. Objetivo Esta revisão integrativa buscou analisar os estudos de avaliação da satisfação de usuários em serviços de saúde bucal, segundo as características metodológicas dos artigos, atributos utilizados, perfil dos usuários e fatores relacionados à satisfação, bem como potencialidades e limitações dos estudos. Método Foi executada uma busca nas bases de dados BBO, Pubmed e Lilacs, para leitura de títulos e resumos e inclusão dos estudos sobre avaliação da satisfação de usuários em serviços de saúde bucal, utilizando os descritores “saúde bucal” e “satisfação do paciente”. Resultados A satisfação esteve associada à autopercepção quanto à saúde bucal, às relações humanas entre usuários e profissionais, à forma de agendamento de consultas. A principal limitação encontrada foi a predominância de respostas positivas dos usuários, devido ao “viés de gratidão” e ao grau de subjetividade na determinação da satisfação. Conclusão As pesquisas apresentam potencialidades quanto ao controle social, empoderamento do usuário e qualificação da gestão e planejamento da atenção odontológica.

Abstract Background The assessment of the satisfaction of patient in the oral health service has its relevance as a measure of effect of health care, on the biopsychosocial aspects of patients, however the literature review studies on the subject are scarce. Objective This integrative review aimed to analyze the studies evaluating the satisfaction of patient in oral health services, according to the methodological characteristics of the research articles, attributes used, patients’ profile and factors related to satisfaction, and the potential and limitations of the studies. Method A search was performed on the databases BBO, Pubmed e Lilacs, for inclusion of studies about satisfaction of patient in the oral health service, 02 descriptors were used: “oral health” and “patient satisfaction”. Results Satisfaction was associated with self-perception about oral health, human relations between patients and professionals, and the way to scheduling consultations. The main limitation found was the predominance of positive responses from patients, due to the “gratitude bias” and the subjectivity in determining satisfaction. Conclusion This research has potential in terms of social control, user empowerment and qualification of management and planning of dental care.

RESUMO Trato da experiência do Teatro Experimental do Negro de São Paulo, companhia teatral menos conhecida que o grupo no qual se inspirou, o Teatro Experimental do Negro do Rio de Janeiro, criado em 1944. Analiso a formação do grupo, propostas, parcerias e engajamentos antirracistas e anticolonialistas, assumidos entre 1945 e 1966. Acervos de jornais e bibliografia disponível sobre o tema foram as principais fontes de consulta e análise.

ABSTRACT This article deals with the Black Experimental Theater of São Paulo experience. It’s a lesser known theater company than Black Experimental Theater of Rio de Janeiro, founded in 1944. My aim is analyzing its conception, goals, partnerships and anti-racist and anti-colonialist commitments, during 1945 and 1966 period. Newspapers archives and the bibliography on such issue were the main sources of analysis.

Resumo Este artigo trata da trajetória intelectual da escritora paulista Ruth Guimarães Botelho (1920-2014), funcionária pública, romancista, tradutora, professora e pesquisadora de folclore. Entre 1946, quando lançou seu primeiro livro, e 2008, quando foi empossada como acadêmica, passaram-se 62 anos até obter reconhecimento institucional, do qual desfrutou por seis anos na Academia Paulista de Letras. Além do lançamento aclamado de sua obra mais conhecida, Água Funda , pela editora Globo, também atuou em editoras de prestígio como tradutora do francês de escritores russo e franceses e, ainda, publicou seus trabalhos de pesquisa sobre o folclore brasileiro. As condições sociais de existência da escritora negra e para a produção e recepção de sua obra são, portanto, questões importantes interpeladas por cruzamentos de fontes variadas e pelas entrevistas inéditas realizadas com a autora.

Abstract This article analyzes some aspects of Ruth Guimarães Botelho’s trajectory (1920-2014) as a black writer and folklore researcher, as well as a few moments of her public life. She became famous with her first published novel in 1946 and, in 2008, she became member of the Academy of Letters of São Paulo. Ruth Guimarães also worked for very important publishing houses as professional translator of French language, specialized in Russian and French authors. I try to understand the social conditions that made Ruth Guimarães and her works possible to exist in some cultural and political contexts. For this purpose, I use interviews and newspapers research combined with specialized bibliography.

ABSTRACT In Colombia Aedes aegypti is present in 80% of the country up to 2,300 m; however, little is known of its genetic relations within a country context and, hence, within a broader context, for example, America. The aforementioned, herein, analyzed the gene flow within a context of the Americas, its directionality and genetic diversity of the mitochondrial lineages in the A. aegypti populations for Colombia. This called for the use of the sequences for A. aegypti available of the mitochondrial ND4 gene in the GenBank for Colombia and the American continent. No presence was found of nuclear mitochondrial pseudogenes (NUMTs) for Colombia. It is estimated that in Colombia the gene flow of the A. aegypti populations is occurring from the southeast and northeast toward the center of the country. In comparison with the mitochondrial sequences for America, the vector’s haplotypes in Colombia suggest connections between the populations of mosquitoes from the south with those from the north of the continent. The gene flow model at continental scale suggests bidirectional connections between the populations from the north of the continent with those from the south, while at South American scale it proposes the gene flow in all the directions with respect to the Colombian. The Colombian A. aegypti vector monitoring and control strategies must pay special attention to the vector’s points of entry into Colombia related with Peru, Venezuela, Brazil, Mexico, and North America to avoid the entry of populations with characteristics like resistance to insecticides or vector competition.