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Abstract In this study, the manufacturing process of lamivudine (3TC) and zidovudine (AZT) tablets (150+300 mg respectively) was evaluated using statistical process control (SPC) tools. These medicines are manufactured by the Fundação para o Remédio Popular “Chopin Tavares de Lima” (FURP) laboratory, and are distributed free of charge to patients infected with HIV by the Ministry of Health DST/AIDS national program. Data of 529 batches manufactured from 2012 to 2015 were collected. The critical quality attributes of weight variation, uniformity of dosage units, and dissolution were evaluated. Process stability was assessed using control charts, and the capability indices Cp, Cpk, Pp, and Ppk (process capability; process capability adjusted for non-centered distribution; potential or global capability of the process; and potential process capability adjusted for non-centered distribution, respectively) were evaluated. 3TC dissolution data from 2013 revealed a non-centered process and lack of consistency compared to the other years, showing Cpk and Ppk lower than 1.0 and the chance of failure of 2,483 in 1,000,000 tablets. Dissolution data from 2015 showed process improvement, revealed by Cpk and Ppk equal to 2.19 and 1.99, respectively. Overall, the control charts and capability indices showed the variability of the process and special causes. Additionally, it was possible to point out the opportunities for process changes, which are fundamental for understanding and supporting a continuous improvement environment. study TC (3TC AZT (AZT 150+300 150300 150 300 (150+30 respectively SPC (SPC tools Chopin Lima FURP (FURP laboratory DSTAIDS DST AIDS program 52 201 collected variation units Cp Pp noncentered non centered distribution years 10 1 0 1. 2483 2 483 2,48 1000000 000 1,000,00 219 19 2.1 199 99 1.99 Overall causes Additionally changes environment 150+30 15030 15 30 (150+3 5 20 248 48 2,4 100000 00 1,000,0 21 2. 9 1.9 150+3 1503 3 (150+ 24 4 2, 10000 1,000, 150+ (150 1000 1,000 (15 100 1,00 (1 1,0 ( 1,