Resumo: As barreiras éticas envolvidas na prática da medicina paliativa pediátrica ainda são grandes e desafiadoras. No que diz respeito à ética médica, deve-se prestar atenção à cultura, religião e valores familiares, a fim de pro-mover um cuidado adequado para os cuidadores, mesmo em caso de perda do paciente, promovendo um pro-cesso de luto com menos sofrimento. Os dados foram analisados qualitativamente pelo software IRAMU-TEQ, com um alto grau de significância das respostas dos ensaios sobre ética relacionada aos cuidados palia-tivos em pediatria. As discussões sobre prognóstico, objetivos de cuidados e opções de tratamento podem ser extremamente desafiadoras, uma vez que as alternativas de cuidados paliativos legalmente suportadas podem divergir dos desejos da família. Nosso estudo conclui que existem divergências entre a implementação da medicina paliativa e a ética em relação à aceitação e manejo do fim da vida de pacientes pediátricos. Os desa-fios éticos são constantemente situações complexas em que os médicos paliativistas devem relacionar concei-tos legais, conhecimento e valores familiares, que frequentemente entram em conflito. A qualidade dos cuida-dos paliativos depende inicialmente da capacidade de profissionais especializados identificarem e explicarem as questões éticas que levam a conflitos ou incertezas, além de levantar discussões com a família sobre ques-tões médicas, morais e legais que cercam a situação difícil.

Resumen: Las barreras éticas involucradas en la práctica de la medicina paliativa pediátrica siguen siendo altas y desafiantes. En términos de ética médica, se debe prestar atención a la cultura, la religión y los valores familiares, con el fin de promover una atención adecuada a los cuidadores, incluso en caso de pérdida de un paciente, promoviendo un proceso de duelo con menos sufrimiento. Los datos fueron analizados cualitativamente por el software IRAMUTEQ, con un alto grado de significación de las respuestas de los ensayos sobre la ética relacionada con los cuidados paliativos en pediatría. Las discusiones sobre el pronóstico, los objetivos de los cuidados y las opciones de tratamiento pueden ser muy difíciles, ya que las alternativas de cuidados paliativos legalmente respaldadas pueden divergir de los deseos de la familia. Se concluye que existen divergencias entre la aplicación de la medicina paliativa y la ética en relación con la aceptación y la gestión del final de la vida de los pacientes pediátricos. Los retos éticos son situaciones constantemente complejas en las que los médicos paliativos deben relacionar conceptos jurídicos, conocimientos y valores familiares, que a menudo entran en conflicto. La calidad de los cuidados paliativos depende inicialmente de la capacidad de los profesionales especializados para identificar y explicar las cuestiones éticas que generan conflicto o incertidumbre, además de plantear debates con la familia sobre las cuestiones médicas, morales y jurídicas que rodean la difícil situación.

Abstract: The ethical barriers involved in the practice of pediatric palliative medicine remain high and challenging. In terms of medical ethics, attention should be paid to culture, religion and family values, in order to promote adequate care for caregivers, even in case of loss of a patient, promoting a bereavement process with less suffering. The data were qualitatively analyzed by IRAMUTEQ software, with a high degree of significance of essay responses on ethics related to palliative care in pediatrics. Discussions about prognosis, goals of care, and treatment options can be very difficult, as legally supported palliative care alternatives may diverge from the wishes of the family. We conclude that divergences exist between the application of palliative medicine and ethics regarding acceptance and end-of-life management of pediatric patients. Ethical challenges are constantly complex situations in which palliative physicians must relate legal concepts, knowledge and family values, which often conflict. The quality of palliative care depends initially on the ability of specialized professionals to identify and explain the ethical issues that generate conflict or uncertainty, in addition to raising discussions with the family about the medical, moral and legal issues surrounding the difficult situation.

The Brazilian regulations for processed coconut water establish the range concentrations of Na and K, being necessary high-throughput analytical methods, as microwave-induced plasma optical emission spectrometry (MIP OES) for quality control. Samples of natural (green and mature) and processed coconut water were treated by acid decomposition assisted by microwave radiation before their MIP OES analysis. Recoveries for Na and K were 103 and 95%, whereas the relative standard deviation (RSDs) were 7.6 and 1.3%, respectively. The limit of detection (LOD) was 1.77 mg kg-1 for K and 2.31 mg kg-1 for Na. Na and K were determined in the ranges of, respectively, 27-490 and 1,600-3,500 mg L-1 in natural samples, whereas in processed samples the ranges were 26-168 and 814-2,054 mg L-1. K-means cluster analysis identified a group of processed samples with compositions similar to green coconut water. All the processed samples were in accordance with the established regulation, except one dehydrated sample for which K content was below the accepted range. Natural coconut water is an excellent source of K in the diet as its daily consumption can supply more than 20% of the recommended daily ingestion of K for adults and 30% for children. highthroughput high throughput methods microwaveinduced induced control mature 10 95 95% RSDs (RSDs 76 7 6 7. 13 1 3 1.3% respectively LOD (LOD 177 77 1.7 kg1 kg kg- 231 2 31 2.3 27490 27 490 27-49 1,6003,500 16003500 1,600 3,500 600 500 1,600-3,50 L1 L L- 26168 26 168 26-16 8142,054 8142054 814 2,054 054 814-2,05 L1. 1. Kmeans means regulation 20 30 children 9 1.3 17 23 2. 2749 49 27-4 6003 1,6003,50 1600350 1600 1,60 3500 3,50 60 50 1,600-3,5 2616 16 26-1 8142 8142,05 814205 81 2054 2,05 05 814-2,0 274 4 27- 1,6003,5 160035 160 1,6 350 3,5 5 1,600-3, 261 26- 8142,0 81420 8 205 2,0 0 814-2, 1,6003, 16003 1, 35 3, 1,600-3 8142, 2, 814-2 1,6003 1,600- 814-

Resumen Buscando contribuir con la gestión de los recursos hídricos en la región del reservorio de Itaipu Binacional, esta investigación tuvo como objetivo caracterizar la dinámica del proceso de evapotranspiración y evaluar el desempeño de diferentes métodos matemáticos, que determinan la evapotranspiración de referencia (ETo) a partir de los valores de temperatura del aire. Se analizaron quince ciudades. Después de obtener la serie de datos, la ETo se estimó utilizando seis métodos: Camargo (C), Hargreaves-Samani (HG-S), Jensen-Haise (JH), Penman-Monteith con datos faltantes (PMm), Thornthwaite-Camargo (TW- C) y Penman-Monteith (PM), siendo este último el método de referencia. El desempeño de los métodos ocurrió mediante varios índices estadísticos. Los valores diarios de ETo variaron de 2 a 10 mm d-1, con una media anual de 5,78 mm d-1. También observamos que ETo es determinada predominantemente por parámetros radiactivos, que anualmente representan el 76% del proceso de evapotranspiración, mientras que los parámetros aerodinámicos representan el 24%. Entre los métodos de estimación de ETo, los métodos HG-S y PMm fueron los más adecuados para estimar.

Abstract Seeking to contribute with the management of water resources in the Itaipu Binacional reservoir region, this research aimed to characterize the dynamics of evapotranspiration and evaluate the performance of different mathematical methods, which determine reference evapotranspiration (ETo) from air temperature values. Fifteen municipalities were analyzed. After obtaining the data series, ETo was estimated using six methods: Camargo (C), Hargreaves-Samani (HG-S), Jensen-Haise (JH), Penman-Monteith with missing data (PMm), Thornthwaite-Camargo (TW-C) and Penman-Monteith (PM) - the latter was the reference method. The performance of the methods was analyzed by several statistical indexes. Daily ETo values ranged from 2 to 10 mm d-1, with an annual mean of 5.78 mm d-1. We also observed that it is determined predominantly by radioactive parameters, which annually represent 76% of the evapotranspiration process, while aerodynamic parameters represent 24%. Among the ETo estimation methods, HG-S and PMm were the most suitable for estimating.

RESUMO A Ciência Forense Digital surgiu da necessidade de tratar problemas forenses na era digital. Seu mais recente desafio está relacionado ao surgimento das mídias sociais, intensificado pelos avanços da Inteligência Artificial. A produção massiva de dados nas mídias sociais tornou a análise forense mais complexa, especialmente pelo aperfeiçoamento de modelos computacionais capazes de gerar conteúdo artificial com alto realismo. Assim, tem-se a necessidade da aplicação de técnicas de Inteligência Artificial para tratar esse imenso volume de informação. Neste artigo, apresentamos desafios e oportunidades associados à aplicação dessas técnicas, além de fornecer exemplos de seu uso em situações reais. Discutimos os problemas que surgem em contextos sensíveis e como a comunidade científica tem abordado esses tópicos. Por fim, delineamos futuros caminhos de pesquisa a serem explorados.

ABSTRACT Digital Forensics emerged from the need to perform forensic tasks in the digital age. Its most recent challenges are related to the popularization of social media and were intensified by the advance of Artificial Intelligence. The generation of massive social media data made forensic analyses more complex, mainly due to improvements in computational models able to artificially create highly realistic content. Because of this, Artificial Intelligence techniques have been studied and used to process the massive volume of information. This paper discusses the challenges and opportunities associated with such methods and provides real case examples, as well as the problems that arise when using these approaches in sensitive contexts and how the scientific community has approached these topics. Finally, it draws future research paths to be explored.

RESUMO OBJETIVOS: Descrever a incidência por gênero e região, a letalidade e os custos associados ao tratamento de fraturas do fêmur em idosos (≥ 60 anos) internados no Sistema Único de Saúde (SUS) do Brasil entre 2008 e 2018. MÉTODOS: Estudo transversal, descritivo e retrospectivo das internações de idosos por fraturas do fêmur mediante análise dos dados secundários obtidos do Sistema de Informações Hospitalares do SUS (SIH/SUS) entre 2008 e 2018; para cálculo dos coeficientes epidemiológicos, utilizamos informações dos censos demográficos (2000 e 2010) do Instituto Brasileiro de Geografia e Estatística (IBGE). RESULTADOS: Foram registradas 478.274 mil internações no período. A incidência foi 1,7 vezes maior no gênero feminino (média geral de 274,91/100.000 para mulheres e 161/100.000 para homens). A região sudeste obteve maior número absoluto de internações e na região sul apresentou a maior incidência média geral anual (224,02/100.000). O custo médio anual do SUS para o tratamento das fraturas de fêmur em idosos foi de R$ 99.718.574,30. CONCLUSÕES: No período avaliado (2008-2018), as fraturas do fêmur em idosos apresentaram alta incidência (478.274 mil internações; 224,02 casos/100.000 idosos), predomínio do gênero feminino (1,7F/1,0M), maior número absoluto de internações na região sudeste e maior incidência na região sul; a letalidade foi elevada (aumento de 17,46%; média geral do coeficiente de 4,99%/ano); e, os custos para o SUS foram vultuosos (aumento de 126,24%, média anual de gastos de R$ 99.718.574,30).

SUMMARY OBJECTIVES: To describe the incidence by gender and region, lethality, and costs associated with the treatment of femoral fractures in the elderly (≥ 60 years) hospitalized in the Unified Health System (SUS) of Brasil between 2008 and 2018. METHODS: This is a cross-sectional, descriptive, retrospective study of hospitalizations of elderly people due to femoral fractures by analyzing secondary data obtained from the SUS Hospital Information System (SIH/SUS) between 2008 and 2018; for calculation of epidemiological coefficients, we used information from demographic censuses (2000 and 2010) of the Brazilian Geography and Statistics Institute (IBGE). RESULTS: A total of 478,274 hospitalizations were recorded in the period; the incidence was 1.7 times higher in females (overall average of 274.91/100,000 for women and 161/100,000 for men). The Southeast region had the highest absolute number of hospitalizations and the South region presented the highest annual overall average incidence (224.02/100,000). The average annual cost for SUS for the treatment of femoral fractures in the elderly was R$ 99,718,574.30. CONCLUSIONS: In the evaluated period (2008-2018), femoral fractures in the elderly had a high incidence (478,274 hospitalizations; 224.02 cases/100,000 elderly), a predominance of females (1.7F/1.0M), a higher absolute number of hospitalizations in the Southeast region and a higher incidence in the South region; the lethality was high (an increase of 17.46%; overall mean coefficient of 4.99%/year); and the costs for the SUS were huge (an increase of 126.24%; average annual expenditure of R$ 99,718,574.30).

An automated method based on open-source hardware was created for the separation of porphyrins fractions from crude oil, an essential step for the quantification of V and Ni as metalloporphyrins. Preparative liquid chromatography was implemented with a reverse phase gradient from MeOH to toluene. The system allows three solvents and fractions changes by using quaternary valves connected to an Arduino microcontroller, programmed on the basis of the absorbance signal measured and its first derivative. Additionally, the method was applied to crude oils (Venezuelan National Institute of Standards and Technology (NIST) 8505 and from a marine reservoir). V and Ni were determined by inductively coupled plasma mass spectrometry (ICP-MS) and the V-porphyrin profile was determined by high performance liquid chromatography (HPLC)-ICP-MS. The concentrations of the metals grow in the last eluting toluene fractions, associated with asphaltenes. On the other hand, V-porphyrins in the first eluting MeOH fractions showed profiles of labile compounds, with a higher percentage in the Brazilian crude oil (4.9 mg L-1, corresponding to 18% of total V), in comparison to the one from the biodegraded NIST 8505 (59 mg L-1, corresponding to 7% of total V). The overall methodology has a good reproducibility and provides information on elements concentrations associated with porphyrin class compounds.

Abstract Fake news has been certainly the expression of the moment: from political round table discussions to newspapers to social and mainstream media. It is everywhere. With such an intense discussion and yet few effective ways to combat it, what can be done? Providing methods to fight back even the least harming hoax is a social responsibility. To look for authenticity in a wide sea of fake news, every detail is a lead. Image appearance and semantic content of text and images are some of the main properties, which can be analyzed to reveal even the slightest lie. In this vein, this work overviews some recent methods applicable to the verification of dubious content in text and images, and discusses how we can put them together as an option to curb away the proliferation of unverified and phony “facts”. We briefly present the main idea behind each method, highlighting real situations where they can be applied and discussing expected results. Ultimately, we show how new research areas are working to seamlessly stitch together all these methods so as to provide a unified analysis and to establish the synchronization in space and time — the X-Coherence of heterogeneous sources of information documenting real-world events.

Abstract The Troschel’s Pampas Snake, Phimophis guianensis (Troschel, 1848), is widely distributed in Amazonian Savannas at northern South America and a small portion of southern Central America, being recorded to Brazil based on three historical records, that ranged from 1997 to 2002, in Amapá and Pará states. In this study, we revise all known records of P. guianensis, providing an updated distribution map, and the first record to Roraima state.

RESUMEN Introducción: Los desórdenes musculoesqueléticos (DME) constituyen una de las principales causas de enfermedad relacionadas con el trabajo. Numerosos esfuerzos se han realizado a fin de prevenir su aparición; por tanto, múltiples instrumentos de evaluación ergonómica han sido usados. Esta revisión tiene como objetivo identificar la información disponible en bases de datos sobre evaluación del riesgo biomecánico (RULA) y percepción de DME en trabajadores de diversos sectores económicos (Cuestionario Nórdico), para el periodo 2004-2015. Materiales y Métodos: Se realizó una revisión sistemática de los estudios recientes enfocados en la evaluación del nivel de riesgo ergonómico y percepción de DME. Asimismo, fueron tenidas en cuenta las recomendaciones de la declaración PRISMA, tras obtener los artículos en las bases de datos Science direct, Scopus, Pubmed, Springer link, Embase y Ebsco. 13 estudios que cumplieron con los criterios de selección fueron incluidos; se identificaron dos tipos de estudios: de diagnóstico y de intervención. Resultados: Prevalencias altas en espalda alta-baja, cuello, tronco, hombros, mano/ muñeca y rodilla fueron evidenciadas, siendo el género femenino el más afectado. Conclusiones: Los hallazgos sugieren asociación entre índice de masa corporal, edad (≥ 25 años), antigüedad en el trabajo (≥ 3 años), trabajo por destajo, horas de trabajo diario ≥ 8 horas, número de pacientes atendidos, RULA (nivel 3 y 4) y DME en cuello, tronco, brazos, antebrazos, espalda baja y zonas corporales del grupo B.

ABSTRACT Introduction: Musculoskeletal disorders (MSD) are one of the main causes of work-related diseases; numerous efforts have been made in order to prevent its occurrence. Therefore, multiple ergonomic evaluation instruments have been used. This review aims to identify the available information in databases related to biomechanical risk assessment (RULA) and perception of DME in workers from various economic sectors, period 2004-2015 (Nordic Questionnaire). Materials and Methods: A Systematic review about the recent studies focused on the evaluation of the level of ergonomic risk and perception of DME was performed. The recommendations of the PRISMA statement were taken into account after obtaining the studies from the Science Direct, Scopus, Pubmed, Springer link, Embase and Ebsco databases. 13 studies that complied the selection criteria were included; 2 types of studies were identified: diagnosis and intervention. Results: High prevalence in upper and lower back, neck, trunk, shoulders, hand/wrist, and knee were evidenced, being the female gender the most affected. Conclusions: These findings suggest an association between body mass index, age (≥ 25 years), seniority at work (≥ 3 years), piecework, daily hours of work ≥ 8 hours, number of patients attended, RULA (level 3 And 4) and DME in the neck, trunk, arms, forearms, lower back and group B body areas.

Results on the optimization of analytical methods for the determination of phosphorus in phosphino-polycarboxylate (PPCA), used frequently as scale inhibitor during oil production, by ICP-AES and ICP-MS are presented. Due to the complex matrix of production waters (brines) and their high concentration in inorganic phosphorus, the separation of organic phosphorus prior to its determination is necessary. In this work, minicolumns of silica immobilized C18 were used. Optimization of the separation step resulted in the following working conditions: (1) prewashing of the column with methanol (80% v/v); (2) use of a flow rate of 5 mL/min and 10 mL/min, respectively, for the preconditioning step and for percolation of the water sample; (3) final elution of organic phosphorus with 7 mL of buffer of H3BO3/NaOH (0.05 M, pH 9) with a flow rate of 1 mL/min. Sample detection limits (3s) for different combinations of nebulizers and spectrometric methods, based on 10 mL water aliquots, are: ICP-AES -Cross flow (47 mg/L) and Ultrasonic (18 mug/L); ICP-MS -Cross flow (1.2 mug/L), Cyclonic (0.7 mug/L) and Ultrasonic (0.5 mug/L). Typical recoveries of organic phosphorus are between 90 and 95% and the repeatability of the whole procedure is better than 10%. The developed methodology was applied successfully to samples from the oil-well NA 46, platform PNA 2, Campos basin, Brazil. Assessment of the PPCA inhibitor was possible at lower concentrations than achieved by current analytical methods, resulting in benefits such as reduced cost of chemicals, postponed oil production and lower environmental impacts.