Search | SciELO

Need help?

Add field +

Search history

No documents were found for your search

Results: 11

au:"Restrepo, Marcos"

Filters

Collection + Options

All
Colombia

5
Brazil

5
Peru

1

Journal + Options

All
Biomédica

3
Revista do Instituto de Medicina Tropical de São Paulo

3
Anales de la Facultad de Medicina

1
Memórias do Instituto Oswaldo Cruz

1
Revista Colombiana de Ciencias Pecuarias

1
Revista Colombiana de Cirugía

1
Revista da Sociedade Brasileira de Medicina Tropical

1

Publication Year + Options

All
1994

2
2006

2
2008

2
1986

1
1988

1
1996

1
2010

1
2016

1

SciELO Thematic Areas + Options

All
Health Sciences

10
Biological Sciences

4
Agricultural Sciences

1

WoS Subject Categories + Options

All
Medicine

9
Tropical

8
Agriculture

1
Animal

1
Care

1
Complementary

1
Dairy

1
Environmental

1
Ethics

1
Experimental

1
General

1
Health

1
Integrative

1
Internal

1
Laboratory

1

Show all...

WoS Citation Index

All
Science Citation Index Expanded

6

Citables and non citables + Options

All
Citable

10
Non citable

1

Type of Literature + Options

All
Article

9
Review article

1
Other

1

Order by

Page of 1 Next

Select this page

Print | Send to email | Export |

Facebook
Twitter
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

0 Selected itens

List all
Erase all

Tripanosomiasis americana, una mirada desde el tratamiento
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Sánchez, Emmanuel

; Vélez, María Camila

; Restrepo, Marcos

; Sebastián Marín, Juan

; Gallego, Daniel

Anales de la Facultad de Medicina

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jan 2016, Volume 77 N. 1 Pages 39 - 44

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

American trypanosomiasis or Chagas disease is a parasitic infection caused by the flagellate parasite Trypanosoma cruzi, whose main vector is an insect of the Hemiptera class, called triatomine. Chemotherapy, in addition to an appropriate vector control and a rigorous control of transfusions, are the most important strategies for the management of this parasitosis. Currently, the pharmaceutical market only offers nifurtimox and benznidazole as treatment options, and although satisfactory results have been obtained with the use of these drugs in either acute stages of the disease, congenital trypanosomiasis and laboratory accidents, its effectiveness in the chronic phases is significantly smaller. In addition, both drugs produce some side effects that must be taken into account by health workers, before starting the proper management of the disease. The aim of this article is to review the current state of the American trypanosomiasis treatment, in order to summarize the new advances in therapeutics and to introduce their limitations due to adverse effects.

La tripanosomiasis americana o enfermedad de Chagas es una infección parasitaria causada por el parásito flagelado Trypanosoma cruzi, cuyo principal vector es un insecto de la clase hemíptera conocido como triatomino. La quimioterapia, adicional a un control oportuno de vectores y rigurosidad en el control de las transfusiones, son los elementos más importantes para el manejo de esta parasitosis. En la actualidad, el mercado farmacéutico solo ofrece nifurtimox y benznidazol como opciones terapéuticas, y a pesar de que se han obtenido resultados satisfactorios con el uso de estos medicamentos en fases agudas de la enfermedad, tripanosomiasis congénita y accidentes de laboratorio, la efectividad en las fases crónicas es notoriamente menor. Además, ambos fármacos generan ciertos efectos adversos que deben ser tenidos en cuenta por el personal de la salud, antes de iniciar el debido manejo de esta enfermedad. El objetivo del presente artículo es revisar el estado actual del tratamiento farmacológico de la tripanosomiasis americana, buscando resumir los nuevos avances terapéuticos y dar a conocer las limitaciones de los mismos debido a sus efectos adversos.

https://doi.org/10.15381/anales.v77i1.11551

Seroprevalencia e incidencia de Brucella sp en vacunadores del Programa para el control de brucelosis bovina, en el Departamento de Antioquia-Colombia
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics

Reyes, Julián

; Sánchez, Miriam

; Lotero, María A

; Restrepo, Marcos

; Palacio, Luis G

Revista Colombiana de Ciencias Pecuarias

Journal Metrics
- Sobre o periódico
- SciELO Analytics

mar 2010, Volume 23 N. 1 Pages 35 - 46

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

La brucelosis es un problema de salud pública en el ámbito ocupacional de trabajadores rurales y ejecutores de los programas de vacunación de la enfermedad en el ganado. La exploración de la positividad y de los factores asociados es necesaria para establecer medidas preventivas en esta población trabajadora. El objetivo de este estudio fue determinar la seroprevalencia e incidencia de Brucelosis en vacunadores del programa para el control de Brucelosis bovina en el Departamento de Antioquia- Colombia. Se realizó un estudio de cohorte concurrente en vacunadores del programa para el control de brucelosis bovina, a quienes se les hizo seguimiento antes y después del ciclo de vacunación con el fin de determinar la seropositividad para brucelosis. Se estimó la positividad con dos pruebas inmunológicas diferentes: Rosa de Bengala y Elisa Competitivo. Para el primer muestreo de 251 personas, de quienes el 10.8% (IC95% 6.4 %-14.3%) fueron positivos a Rosa de Bengala. En el segundo muestreo participaron 220 personas, de quienes el 15.4% (IC95%10.4 % -20.4%) resultaron positivas. Se observó una seroconversión del 5.75% 2.0-9.5) para Rosa de Bengala. La positividad general encontrada por Elisa Competitivo para el (IC95% primer muestreo fue del 25% (IC 95% 8.65 – 49.10), y para el segundo muestreo del 34.3% (IC95% 17.13 – 51.4). Se observó una seroconversión del 5.75% (IC 95% 2.002-9.493) para Rosa de Bengala y del 38.5% (IC 95% 13.858-68.422). No se encontraron diferencias entre las proporciones de positividad entre los muestreos, sin embargo la seroconversión individual es un aspecto que puede alterar esta diferencia si se realiza un seguimiento más prolongado de cada una de las variables.

Brucellosis is a public health problem in the occupational context of abattoir workers and cattle vaccinators. The exploration of positives and its associated factors is necessary to the establishment of preventive measures on this population. The objective of the present study was to determine the seroprevalence and incidence of Brucellosis in workers of the Brucellosis control program in Antioquia – Colombia. It took place a cohort study in two different moments, before the cycle and after the cycle. For the first moment there were 251 individuals and for the second 221. Every individual was explored by a complete questionnaire. In the other hand all workers were subject to vennopunction and blood extraction, for serology examination with Rose Bengal test and Competitive ELISA. They were examinated sociodemographic, occupational and clinical variables in all the participants of the study. The seroprevalence of Rose Bengal test (RBT) for the first moment of the study was 10.8 (IC 95% 6.3914.32) in the second moment the seroprevalence was 15.4% (IC 95% 10.40 -20.36) with the same test. The seroconvertion was 5.7% (IC 95% 2.002-9.493) para RBT. There were no significant differences between the positivity proportions in both moments of the study, therefore at the individual level seroconvertion it’s suggesting that these individuals are at occupational risk and this will result, with a longer surveillance period among this group in significative results.

A bruceloses é um problema de saúde pública no âmbito ocupacional de trabalhadores rurais e executores de programas de vacinação da doença no gado. A exploração da positividades e dos factores associados é necessária para estabelecer medidas preventivas na população trabalhadora. O objectivo deste trabalho foi determinar a seroprevalência e incidência de Bruceloses em vacinadores do programa para o controle da Bruceloses bovina no Departamento da Antioquia (Colômbia). Foi realizado um estudo de tipo concorrente em vacinadores do programa de controle, com seguimento antes e depois do ciclo de vacinação, com o propósito de determinar a seropositividade para bruceloses. Foi estimado a positividade com os testes Rosa de Bengala e Elisa Competitivo. Para a primeira amostragem de 251 pessoas, o 10.8% (IC95% 6.4 % -14.3%) foram positivos a Rosa de Bengala. Na segunda amostragem, participaram 220 pessoas, das quais o 15.4% (IC95%10.4 % -20.4%) resultaram positivas. Se observou uma seroconversão do 5.75% (IC95% 2.0-9.5) para Rosa de Bengala. A positividade geral encontrada por Elisa Competitivo para a primeira amostragem foi do 25% (IC 95% 8.65 – 49.10), e para a segunda amostragem do 34.3% (IC95% 17.13 – 51.4). Foi observado uma seroconversão do 5.75% (IC 95% 2.002-9.493) para Rosa de Bengala y do 38.5% (IC 95% 13.858-68.422). Não foram encontradas diferenças entre as proporções de positividade entre amostragens, embora, a seroconversão individual é um aspecto que pode dar resultados diferentes, ao realizar um seguimento mais prolongado de cada uma das variáveis.

2499 downloads Cited 3 times in SciELO

Concordancia entre gota gruesa, inmunocromatografía y reacción en cadena de la polimerasa para el diagnóstico de malaria
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics

Montoya, Astrid Elena

; Menco, José

; Osorio, Natalia

; Zuluaga, María Alejandra

; Duque, Juliana

; Torres, Giovanny

; Restrepo, Marcos

Biomédica

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jun 2008, Volume 28 N. 2 Pages 252 - 261

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Introducción. El diagnóstico oportuno y efectivo del paludismo, o malaria, son condiciones determinantes para hacer un tratamiento adecuado de la enfermedad y un control de la misma. Objetivo. Se evaluó la concordancia de la sensibilidad, especificidad, valor diagnóstico positivo y negativo de una prueba rápida y de la reacción en cadena de la polimerasa (PCR), con la prueba estándar, la gota gruesa, para el diagnóstico de la malaria. Materiales y métodos. Se analizó una población de 100 pacientes con signos y síntomas indicativos de paludismo, procedentes de las zonas de Urabá, Córdoba, Bajo Cauca y de otras regiones de Colombia, como Valle, Chocó y Vichada, todas áreas endémicas de la enfermedad. A cada paciente se le practicó una gota gruesa, la prueba rápida OptiMAL® y la amplificación a través de una PCR de secuencias de ADN específicas para género y para Plasmodium falciparum y Plasmodium vivax. Resultados. La sensibilidad de la prueba rápida frente a la gota gruesa, para el diagnóstico de ambas especies de Plasmodium fue de 93,85% (IC95% 87,23-100) y la especificidad de 94,29% (IC95% 85,17-100). La PCR comparada con la gota gruesa mostró una sensibilidad de 100% (IC95% 99,23-100) y una especificidad de 97,14% (IC95% 90,19-100). Conclusiones. Estos hallazgos muestran que la sensibilidad y especificidad de la prueba rápida y la PCR para el diagnóstico de malaria son comparables con el examen al microscopio de la gota gruesa, recomendada por su eficacia y bajo costo.

Introduction. The rapid and effective diagnosis of malaria is the determining condition for an appropriate treatment and control of the disease. Objective. The sensitivity, specificity and the positive and negative predictive values were evaluated in cases of suspected malaria in Colombia in a comparison of a rapid diagnostic test. the PCR test and the thick blood smear-the traditional ‘gold standard.’ Materials and methods. A group of 100 patients with symptoms compatible with malaria, were included in the study. They were selected from the following Colombian regions: Urabá, Córdoba, lower Cauca, and relatively fewer from other malaria endemic areas of Colombia including the provinces of Valle, Chocó in the central west of Colombia and Vichada to the east. To each patient the following three tests were performed: the rapid OptiMAL® test, the PCR identification and the thick blood smear. The PCR amplified specific DNA sequences with primers designed to identify the genus Plasmodium, and the two species present in Colombia, P. falciparum and P. vivax. Results. The sensitivity of the rapid test versus the thick smear, for the diagnosis of both species of Plasmodium was 93.9% (95% CI: 87-100%) and the specificity was 94.3% (95% CI:.253 85-100%). The PCR compared with the thick smear showed a sensitivity of 100% (95% CI: 99-100%) and a specificity of 97.1% (95% CI: 90-100%). Conclusions. The sensitivity and specificity of the three tests did not present statistically significant differences. However, the thick blood smear was recommended as the standard test, mainly due to its low cost.

4700 downloads Cited 2 times in SciELO

Diagnóstico de leptospirosis de muestras de sangre y cultivo por observación en microscopio de campo oscuro
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics

Agudelo-Flórez, Piedad

; Restrepo, Marcos

; Moreno, Natalí

Biomédica

Journal Metrics
- Sobre o periódico
- SciELO Analytics

mar 2008, Volume 28 N. 1 Pages 7 - 9

Abstract: Es | Text: Es | PDF: Es

17004 downloads Cited 1 time in SciELO

Primer Consenso Colombiano en Sepsis
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics

Restrepo, Marcos I

; Dueñas, Carmelo

; González, Marco

; Ortiz, Guillermo

; Álvarez, Carlos

; Granados, Marcela

; Acosta, Carlos

; Arias, Arturo

; Atehortúa, Luis H

; Camargo, Rubén

; Carvajal, Martín

; de la Rosa, Gisela

; Durán, Julio

; Echeverri, Juan L

; Gil, Bladimir

; Hurtado, Carlos

; Martínez, Ernesto

; Rebolledo, Carlos

; Saavedra, Carlos

; Sandoval, Julio

; Velandia, Julio

; Vélez, José A

; Vélez, Juan D

Revista Colombiana de Cirugía

Journal Metrics
- Sobre o periódico
- SciELO Analytics

sep 2006, Volume 21 N. 3 Pages 155 - 179

Abstract: Es | Text: Es | PDF: Es

1061 downloads

Evaluación de la prueba de inmunofluorescencia indirecta para el diagnóstico de leptospirosis humana
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics

Agudelo-Flórez, Piedad

; Restrepo, Marcos

; Lotero, María Amparo

Biomédica

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jun 2006, Volume 26 N. 2 Pages 216 - 223

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Introducción. El diagnóstico de la leptospirosis es difícil debido al amplio espectro de síntomas clínicos que presenta. Varias pruebas diagnósticas serológicas se han desarrollado, pero su aplicación y utilidad en Colombia no han sido determinadas. Objetivos. Evaluar la prueba de inmunofluorescencia indirecta para el diagnóstico de leptospirosis humana y determinar así los anticuerpos de las clases inmunoglobulina G y M producidos contra Leptospira. Materiales y métodos. Se establecieron tres grupos de estudio. El primero incluyó 19 muestras positivas para leptospirosis de pacientes con diagnóstico clínico y prueba de microaglutinación positiva; el segundo, 40 muestras de personas sin antecedentes de leptospirosis y con microaglutinación negativa, y el tercero con 96 muestras de pacientes con otras enfermedades diferentes a leptospiris. Todas las muestras fueron procesadas por inmunofluorescencia indirecta. Resultados. Se determinó que la inmunofluorescencia indirecta tiene sensibilidad de 89,47%, especificidad de 100%, valor predictivo negativo de 95,2% (IC95% 82,6 a 99,2) y valor predictivo positivo de 100%. En forma paralela, un estudio exploratorio en 27 muestras de suero que habían sido remitidas para diagnóstico de diferentes síndromes febriles encontró que 11% de ellas fueron positivas por inmunofluorescencia indirecta para anticuerpos IgM contra Leptospira. Conclusiones. La inmunofluorescencia indirecta es una alternativa que complementa el diagnóstico de leptospirosis y los estudios seroepidemiológicos. La presencia de anticuerpos dirigidos contra Leptospira en las muestras de síndrome febril del estudio indica que la leptospirosis es una de las causas de este síndrome que el clínico debe explorar.

Introduction. The diagnosis of leptospirosis is difficult because it presents an extremely broad spectrum of symptoms. A number of diagnostic serological assays have been developed, but their performance and utility have not been evaluated in Colombia. Objectives. To evaluate the IgM-IgG-indirect inmunofluorescence assay to detect antibodies against Leptospira in human serum samples and to diagnose leptospirosis. Materials and methods. A panel of 19 sera from leptospirosis cases with clinical diagnosis and positive microscopic agglutination test, 40 samples from individuals without history of leptospirosis and negative microscopic agglutination test, and 96 samples from patients with other infectious diseases were evaluated. Results.The sensitivity of the indirect inmunofluorescence assay was 89.47%, its specificity was 100%, the negative predictive value was 95.2% (CI 95% 82.6-99.2), and its positive predictive value was 100%. At the same time an exploratory study of 27 samples from different febrile syndromes, 11% were positive by IgM-indirect inmunofluorescence assay against Leptospira. Conclusions. The data indicate that indirect inmunofluorescence assay is useful as a diagnostic adjunct to clinical diagnosis and for seroepidemiologic studies. The presence of IgM antibodies against Leptospira in sera from cases of febrile syndrome indicate that leptospirosis is one of the causes of this syndrome and should be considered by the clinician.

7503 downloads Cited 6 times in SciELO

Diagnostic tests for amoebic liver abscess: comparison of enzyme - linked immunosorbent assay (Elisa) and counterimmunoelectrophoresis (CIE)
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics

Restrepo, Marcos I.

; Restrepo, Zoraida

; Villareal, Consuelo López Elsa

; Aguirre, Aura

; Restrepo, Marcos

Revista da Sociedade Brasileira de Medicina Tropical

Journal Metrics
- Sobre o periódico
- SciELO Analytics

feb 1996, Volume 29 N. 1 Pages 27 - 32

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O abscesso hepático é a complicação mais freqüente da amebíase intestinal: o seu diagnótico sugere-se pelo quadro clínico, mas é confirmado pelos estudos paraclínicos. Para confirmar o diagnóstico precisa-se identificar a E. histolytica, o que é apenas possível em muito poucos casos. As provas sorolôgicas melhoram notadamente o diagnóstico das complicações severas da amebíase. Em nosso estudo comparamos o teste de ELISA e a Contraimunoeletroforese (CIE). Ambas as técnicas foram utilizadas para detectar anticorpos contra ameba em 50 pacientes sem amebíase, 30 pacientes com abscesso hepático e 30 com amebíase intestinal. Todos os soros dos pacientes sem amebíase foram negativos por ambas as técnicas. Quando analisamos os soros dos pacientes com amebíase intestinal, encontrou-se que 10% destes, foram positivos para ELISA, enquanto que nenhum o foi para CIE. Nos soros dos pacientes com abscesso hepático, encontrou-se uma positividade de 90% para ELISA e 66.6% para CIE. Estes resultados mostram que o teste de ELISA foi de maior sensibilidade (100%i de sensibilidade) no diagnóstico do abscesso hepático amebiano, quando comparado com a Contraimunoeletroforese (66.6%).

The liver abscess is the most frequent extraintestinal complication of intestinal amoebiasis: its diagnosis is suggested by the clinical picture but it must be confirmed by paraclinic tests. Themost stringent diagnosis requires identification of E. histolytica. But this is possible only in a few cases. Serological tests greatly improve the diagnosis of this severe complication of amoebiasis. We compared the Enzyme Linfed Immunosorbent Assay and the Counterimmunoeletrophoresis techniques. Both techniques were used to detect amoebic antibodies in 50 control patients, 30 patients with liver abscess and 30 patients with intestinal amoebiasis. All the sera from control patients gave negative results iin both techniques. When analysing the sera from patients with intestinal amoebiasis, 10% of them were positive by ELISA but non by CIE. The sera of patients with liver abscess, we found that 90% were positive by the ELISA method and 66.6% by the CIE technique. In patients with amoebic liver abscess, the results showed that the ELISA was more sensitive than the CIE, as it presented a higher sensitivity (100%) than that of the CIE technique (66%).

7036 downloads

Standardization and evaluation of ELISA for the serodiagnosis of amoebic liver abscess
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics

Nicholls, R. Santiago

; Restrepo, Marcos I.

; Duque, Sofia

; Lopez, M. Consuelo

; Corredor, Augusto

Memórias do Instituto Oswaldo Cruz

Journal Metrics
- Sobre o periódico
- SciELO Analytics

mar 1994, Volume 89 N. 1 Pages 53 - 58

Abstract: En | Text: En | PDF: En

An ELISA test for the serological diagnosisof amoebic liver abscess (ALA) was standardized and evaluated in sera from three groups of patients: (1) three patients with diagnosis confirmed by isolation of the parasite,(2) thirty seven patients with diagnosis established by clinical findings and ultrasound studies and (3) seven patients whose diagnosis were established by clinical findings and a positive double immunodifusion test. Ninety one serum samples from healthy subjects and 22 from patients with other liver or parasitic diseases were also included in the study. the optimum concentration of Entamoeba histolytica antigen was 1.25 µg/ml and optimum dilutions of serum and anti-human IgG-alkaline phosphatase conjugate were 1:400 and 1:4000 respectively. The cut-off point of the ELISA test in this study was an absorbance value of 0.34. The test parameters were: sensitivity = 95.7 per cent, specificty = 100 per cent, positive predictive value = 100 per cent and negative predictive value = 98.2 per cent.The ELISA test was found to be of great use as a diagnostic tool for the establishment of amoebic etiology in patients with clinical supposition of ALA. The test could also be used for seroepidemiological surveys of the prevalence of invasive amoebiasis in a given population, since it allows the processing of a greater number of samples at a lower cost tahn other serological tests.

2040 downloads

Blood groups and malaria
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics

Montoya, Fabiola

; Restrepo, Marcos

; Montoya, Astrid E.

; Rojas, William

Revista do Instituto de Medicina Tropical de São Paulo

Journal Metrics
- Sobre o periódico
- SciELO Analytics

feb 1994, Volume 36 N. 1 Pages 33 - 38

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

The possible relationship between erythrocyte antigens and the presence of malaria infection by P. vivax and P. falciparurn was sought in four different ethnic groups of two departments of Colombia. Malaria infection by P. falciparum was found in 91.4% of malaria infected blacks. No significant differences were found between the presence of malaria infection and ABO antigens. In the other blood groups, it was observed that groups MNSs conferred black people a greater Rr for malaria by both species of Plasmodium and that Duffy-negative blacks and indians appeared to be resistant to P. vivax infection. A predominance of P. vivax infection was observed in Katio indians while P.falciparum was predominant in Kuna indians; the reason for this finding still needs to be explored.

Con el presente estudio se evalúa la relación existente entre la infección por P. vivax y P. falciparum y los antígenos eritrocitos de cuatro diferentes grupos étnicos en Colombia. P. falciparum se encontró causando malaria en el 91.4% de los individuos de raza negra que tuvieron malaria. No hubo diferenciais significativas entre la infección malaria y los antígenos ABO. La presencia de grupos del sistema MNSs en persona de raza negra confiere un mayor riesgo relativo por la infección para las dos especies de Plasmodium, igualmente hay mayor riesgo cuando se pertenece a la raza negra o indígena y el grupo Duffy es negativo. La infección por P. vivax predomina en los indios Katios pero en los Kunas prevalece P. falciparum.

7219 downloads Cited 4 times in SciELO

10.

HLA and malaria in four colombian ethnic groups
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics

Restrepo, Marcos

; Rojas, William

; Montoya, Fabiola

; Montoya, Asirid E.

; Dawson, Deborah V.

Revista do Instituto de Medicina Tropical de São Paulo

Journal Metrics
- Sobre o periódico
- SciELO Analytics

oct 1988, Volume 30 N. 5 Pages 323 - 331

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Foram estudados os antigenos HLA e a relação destes com a infecção malárica em 4 diferentes grupos étnicos da Colômbia (América do Sul); dois grupos de índios (Kunas e Katios), um grupo de negros e um grupo que apresentava ancestrais mistos. Foram estudadas 965 pessoas, das quais 415 com malária e 550 como controles. A freqüência dos antígenos HLA-A, B e C foram determinados nos quatro grupos estudados. A associação de cada antígeno HLA com a infecção por P. vivax e P. falciparum foi avaliada. Os antígenos HLA 6-9 encontrados no grupo de ancestrais mistos, de um modo geral não foram observados nos grupos de negros e índios (Kunas e Katios). Nos grupos étnicos mencionados, os antigenos B5, B13, B15, Cw2 e Cw4 apresentaram uma associação limítrofe com a infecção por malária. Entretanto, no grupo étnico de ancestrais mistos foi observada uma associação estatisticamente significativa com a infecção malárica, sendo que a presença de A9, Aw19, B17, B35 e Z98 (B21-B45: determinantes de reação cruzada) mostrou poucas diferenças quando as infecções por P. vivax e P. falciparum foram consideradas individualmente. Esse achado pode representar, de um modo geral, uma falta de resistência a malária no grupo portador de antigenos de origem caucasiana, os quais tem tido um contacto direto e permanente com a malária somente nos últimos 65 anos. Em contraste, os índios (Kunas e Katios) e os negros tem vivido durante séculos em áreas endêmicas para malária, é possível que um sistema de seleção natural tenha sido desenvolvido permitindo que somente aqueles indivíduos capazes de iniciar uma resposta imune à malária sobrevivam.

HLA antigens and their relationship with malaria infection were studied in four different ethnic groups in Colombia (South America): two groups of indians (Kunas and Katios), one of negroes and a group of mixed ancestry. A total of 965 persons were studied, 415 with malaria and 550 as controls. HLA-A,B, and C antigen frequencies in the four groups are reported. The association of each HLA antigen with malaria infection due to P. vivax and to P. falciparum was evaluated. Negroes, Kunas and Katios indians variously lack from 6 to 9 of the HLA antigens found in the mixed group. In the designated ethnic groups, antigens B5, B13, B15, Cw2 and Cw4 showed borderline association with malaria infection. However, in the mixed ethnic group, statistically significant associations were found with malaria infection and the presence of A9, Aw19, B17, B35, and Z98 (a B21-B45: crossreacting determinant) with few differences when P. vivax infection and P. falciparum infection were considered individually. This finding may represent a lack of general resistance to malaria in the group that harbors antigens of Caucasian origin. These individuals have been in direct and permanent contact with malaria only in the past 65 years. In contrast, indians, both Kunas and Katios, and Negroes have lived for centuries in malaria endemic areas, and it is possible that a natural selection system has developed through which only those individuals able to initiate an acute immune response to malaria have survived.

1673 downloads

11.

Tratamiento com levamisol de la infeccion por Mansonella ozzardi
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics

Restrepo, Marcos

; Ochoa, Nubla

Revista do Instituto de Medicina Tropical de São Paulo

Journal Metrics
- Sobre o periódico
- SciELO Analytics

apr 1986, Volume 28 N. 2 Pages 104 - 110

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Administration of levamisole at the adult dosage (150mg/day) for period of 2-3 months, was found to be associated with diminishing numbers and late disappearence of circulating Mansonella ozzardi microfilarias. No adverse reactions to the drug were recorded. The degree of circulating eosinophils served as indicator of the microfilaria presence.

La administración de levamisol a la dosis para adultos, de 150 mg durante 2 a 3 meses, estuvo asociada la disminución y finalmente a la desaparición de microfilarias circulantes de Mansonella ozzardi. No se presentaron reacciones secundarias a la droga y la eosinofilia circulante, sirvió como indicador de la presencia de microfilarias.

16510 downloads Cited 1 time in SciELO

Showing

itens per page

Page of 1 Next

Select one or more results

All Alphabetic

Results

Comparative chart Download CSV

Statistics of

Send result

To*

Use ; (semicolon) to insert more emails.

Send to email

This page

Selected records

All references (max. 300)

Your email

Subject

Comments

Export format:

RIS (for EndNote, ProCite, Reference Manager, RefWorks, Citavi, etc.)

BibTeX

Citation

CSV (for Excel, etc)

Export:

This page

Selected itens

All references (max. 2000)

Sem resultados

No documents were found for your search

Glossary and search help

You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.

For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

See below the complete list of search indexes that can be used:

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

SciELO - Scientific Electronic Library Online
Rua Dr. Diogo de Faria, 1087 – 9º andar – Vila Clementino 04037-003 São Paulo/SP - Brasil
Email: scielo@scielo.org

All the contents of this site www.scielo.br, except where otherwise noted, is licensed under a Creative Commons Attribution License.
more »