The purpose of this study was to determine the anatomic parameters of the kidney in adults. The Renal lengths, width at superior and inferior poles, thickness at the superior and inferior poles were measured in 151 adult cadaver kidneys. A digital vernier caliper was used for performing the measurements. The data were statistically analyzed. The mean renal length was 8.9 ± 0.9 cm on the right side and 9.1 ± 0.9 cm on the left side. The mean width of the superior pole of the right kidney was 4.9 ± 0.6 cm and the left kidney was 5 ± 0.7 cm. The width of inferior pole of the right and left kidneys were 4.8 ± 0.6 cm and 4.5 ± 0.7 cm respectively. The mean thickness of the superior pole of the right kidney was 3 ± 0.4 cm and left kidney was 3.2 ± 0.5 cm. The mean thickness of the inferior pole of the right and left kidneys were 3.1 ± 0.4 cm and 3.2 ± 0.5 cm respectively. There was no statistical significance with respect to the length of both the kidneys. However there was some data on width and thickness among the right and left side showed the difference which was significant statistically. The present study has provided additional information on the renal morphometry which will be of use to the surgeons and radiologists.

El propósito de este estudio fue determinar los parámetros anatómicos del riñon en los adultos. La longitud renal, ancho de los polos inferior y superior, y grosor de los polos superior e inferior se midieron en riñones de 151 cadáveres adultos. Se utilizó un caliper vernier digital para realizar las mediciones y los datos fueron analizados estadísticamente. La longitud media renal fue 8,9±0,9 cm en el lado derecho y 9,1±0,9 cm en el lado izquierda. El ancho promedio del polo superior del riñón derecho fue 4,9±0,6 cm y del riñón izquierdo fue 5±0,7 cm. El ancho promedio del polo inferior del lado derecho e izquierdo riñones fueron 4,8±0,6 cm y 4,5±0,7 cm, respectivamente. El grosor promedio del polo superior en el riñón del lado derecho fue 3±0,4 cm y el izquierdo 3,2±0,5 cm. El grosor promedio del polo inferior del riñon del lado derecho e izquierdo fueron 3,1±0,4 cm y 3,2±0,5 cm, respectivamente. No hubo diferencia significativa en relación con la longitud de los riñones. Sin embargo hubo algunos datos en ancho y grosor entre el lado derecho e izquierdo que mostraron diferencia significativa. El presente estudio ha proporcionado información adicional sobre la morfometría renal que puede ser de utilidad para los cirujanos y radiólogos.

A lumbosacral transitional vertebra is a rare congenital anomaly which occurs because of defect in the segmentation of the lumbosacral spine during development. During routine osteology classes for the medical students at the Kasturba Medical College, Mangalore, India, one of the sacra showed the fusion of the fifth lumbar vertebra with the sacrum. The specimen showed an incomplete fusion (sacralization) on the left side and the transverse process was of the large butterfly shape, while on the right it was about the usual size. Though this variation is well known, the details of this anomaly are rarely reported in the anatomical literature. Since there is a strong relationship between the lumbosacral transitional vertebrae and low back pain, this anomaly has gotten increased clinical interest. So this case was studied in detail with relevant review of literature and its surgical, radiological implications are discussed.

Una vértebra de transición lumbosacra es una anomalía congénita rara que se produce debido a defectos en la segmentación de la columna lumbosacra durante el desarrollo. Durante una clase de osteología para estudiantes de medicina en Kasturba Medical College, Mangalore, India, una de las regiones sacras mostró fusión de la quinta vértebra lumbar con el sacro. El especimen mostró fusión incompleta (sacralización) en el lado izquierdo y el proceso transverso tenía forma de mariposa grande, mientras que en el derecho se observó de tamaño normal. A pesar que esta variación es conocida, los detalles de esta anomalía rara vez son reportados en la literatura anatómica. Puesto que existe una fuerte relación entre las vértebras de transición lumbosacra y el dolor de espalda baja, esta anomalía tiene gran interés clínico. Este caso fue estudiado en detalle con la revisión pertinente de la literatura, y son discutidas sus implicancias quirúrgicas y radiológicas.

The aim of the present study was to obtain the measurements of the different humerus segments and to estimate the length of humeri from them. For this purpose 100 (51 left and 49 right) sex-aggregated, adult dry humerus from Indian population, were taken to analyze the morphometric details of the humerus segments. The distance between five different segments viz: most proximal point of the humeral head and greater tuberosity (HA), head of the humerus and surgical neck of humerus (HB), proximal and distal point of olecranon fossa (HC), the distal point of olecranon fossa and trochlea of humerus (HD), proximal point of olecranon fossa and distal point of trochlea of humerus (HE) and finally the maximum length of humerus (HL) were obtained by means of an osteometrical board and an analogical caliper. Simples linear regressions (p < 0.01) were made to correlate each segment with the total length of the humerus. Positive results were obtained in segments HB and HE of right humerus. Regressions formulae were obtained to define these estimative. In conclusion, our study demonstrated that length of the humerus can be estimated from measures of different segments of humerus and this study helps in forensic, anatomic and archeological cases in order to identify unknown bodies and to determine stature of the individual and as well as for the orthopedic surgeons for the treatment of proximal and distal humerus fractures and for their reconstruction.

El objetivo del estudio fue obtener las medidas de diferentes segmentos del húmero y calcular la longitud del húmero a partir de ellos. Fueron seleccionados 100 (51 izquierdos y 49 derechos) húmeros adultos secos, separados por sexo, de población india para analizar los detalles morfométricos de los segmentos dle hueso. La distancia entre cinco segmentos diferentes fueron establecidos: punto más proximal de la cabeza humeral y la tuberosidad mayor (HA), cabeza del húmero y cuello quirúrgico del húmero (HB), punto proximal y distal de la fosa olecraneana (HC), punto distal de la fosa olecraneana y la tróclea del húmero (HD), punto proximal de la fosa olecraneana y punto distal de la tróclea del húmero (HE) y, finalmente, la longitud máxima del húmero (HL) medidas obtenidas por medio de una tabla osteométrica y un caliper análogo. Se realizaron regresiones lineales simples para correlacionar cada segmento con la longitud total del húmero. Se obtuvieron resultados positivos en los segmentos de HB y HE de húmero derecho. Fórmulas de regresión se obtuvieron para definir estimativos. En conclusión, nuestro estudio demostró que la longitud del húmero puede estimarse a partir de las medidas de los diferentes segmentos del hueso, ayudando en casos forenses, anatómicos y arqueológicos con el fin de identificar cuerpos desconocidos o para determinar la estatura de la persona, así como a cirujanos ortopédicos para el tratamiento de las fracturas proximales y distales del húmero o para su reconstrucción.

INTRODUCTION: General surgeons dealing with laparoscopic herniorrhaphy should be aware of the aberrant obturator artery that crosses the superior pubic ramus and is susceptible to injuries during dissection of the Bogros space and mesh stapling onto Cooper's ligament. The obturator artery is usually described as a branch of the anterior division of the internal iliac artery, although variations have been reported. MATERIALS AND METHODS: The present study was conducted on 98 pelvic halves of embalmed cadavers, and the origin and course of the obturator artery were traced and noted. RESULTS: In 79% of the specimens, the obturator artery was a branch of the internal iliac artery. It branched off at different levels either from the anterior division or posterior division, individually or with other named branches. In 19% of the cases, the obturator artery branched off from the external iliac artery as a separate branch or with the inferior epigastric artery. However, in the remaining 2% of the specimens, both the internal and the external iliac arteries branched to form an anastomotic structure within the pelvic cavity. CONCLUSION: The data obtained in this study show that it is more common to find an abnormal obturator artery than was reported previously, and this observation has implications for pelvic surgeons and is of academic interest to anatomists. Surgeons dealing with direct, indirect, femoral, or obturator hernias need to be aware of these variations and their close proximity to the femoral ring.

Variações arteriais de partes distais dos membros inferiores estão bem documentadas e podem ser demonstradas com o auxílio de ultra-sonografia Doppler ou por arteriografia. Entretanto, a ausência ou variação da artéria tibial posterior é um raro achado. Apresentamos um caso de artéria tibial posterior hipoplásica que terminava suprindo o músculo solear. Esse suprimento arterial variante foi fornecido pela artéria peroneal aumentada que continuava como artéria plantar lateral. Estar consciente dessas variações é importante para cirurgiões vasculares ao realizarem reconstruções arteriais em procedimentos de derivação femorodistal, bem como para ortopedistas durante correção cirúrgica do pé torto.

Arterial variations of distal parts of lower extremities are well-documented and can be demonstrated with the help of Doppler ultrasound or by arteriography. However, absence or variation of posterior tibial artery is considered a rare finding. We present a case of hypoplastic posterior tibial artery that terminated by supplying soleus muscle. The variant arterial supply to the sole was provided by the enlarged peroneal artery that continued as the lateral plantar artery. The awareness of these variations is important to vascular surgeons while performing arterial reconstructions in femorodistal bypass graft procedures, and also to orthopedists during surgical clubfoot release.

During routine dissection in the Department of Anatomy, multiple variations of forearm muscles in relation to the radial nerve and its branches were observed on the right side of a 34 year old male cadaver. Brachioradialis close to its origin was receiving muscle fibers from the brachialis and the radial nerve was passing in between them. Extensor carpi radialis brevis was absent and the extensor carpi radialis longus was giving two tendons in the second compartment of extensor retinaculum before its insertion while passing deep to the abductor pollicis longus. Absence of extensor carpi radialis brevis can be explained with the arrangement in lower mammals, where the two extensores carpi radiales are represented by one muscle. Ontogeny repeats phylogeny and anatomical variations have developmental basis. Henee, the pattern of muscular arrangement in this case can be said to be less evolved than the usual arrangement. The course of radial nerve between the two heads of brachioradialis makes it highly vulnerable to compression and injury, which may manifest as wrist drop (radial nerve palsy) or radial tunnel syndrome (compression of posterior interosseous nerve).

Durante una disección de rutina en el Departamento de Anatomía, se observaron múltiples variaciones de los músculos del antebrazo, en relación con el nervio radial y sus ramos, en el lado derecho de un cadáver de 34 años de edad, de sexo masculino. Cerca de su origen el músculo braquioradial recibía fibras del músculo braquial y el nervio radial cruzaba entre ellos. El músculo extensor radial corto del carpo se encontraba ausente y el músculo extensor radial largo del carpo se continuaba con dos tendones en el segundo compartimiento del retináculo extensor, bajo el músculo abductor largo de pulgar, antes de su inserción. La ausencia del músculo extensor radial corto del carpo se puede explicar en mamíferos inferiores, donde los dos músculos extensores radiales están representados por un sólo músculo. La ontogenia repite la filogenia y las variaciones anatómicas inciden en su desarrollo. Por lo tanto, de acuerdo al patrón muscular se puede afirmar que en este caso existe menos evolución que lo habitual. El curso del nervio radial entre las dos cabezas del músculo braquioradial, lo hace muy vulnerable a la compresión y las lesiones, que pueden manifestarse son, caída de la muñeca (parálisis del nervio radial) o el síndrome del túnel radial (compresión del nervio interóseo posterior).

Many of the anatomical variations that are inadequately described or quantified are actually more clinically and surgically significant than being just anatomical curiosities. We report about such a variation where an aberrant slip existed in the scalene group, in a 56 year old embalmed female cadáver. This kind of variation may affect the size of the scalene triangle, and thus, may potentially result in varied signs and symptoms in patients vulnerable to thoracic outlet syndrome (TOS). Proximity of the scalene muscles to the brachial plexus, subclavian artery and vein, coexisting with aberrant slips or bundles may also predispose to compression syndromes.

Muchas de las variaciones anatómicas no están suficientemente descritas o cuantificadas y son actualmente clínica y quirúrgicamente significativas más que curiosidades anatómicas. Reportamos una variación anatómica en el grupo de los músculos escalenos, presente en un cadáver de una mujer de 56 años. Este tipo de variación puede afectar el tamaño del triángulo escalénico y por lo tanto, puede potencialmente resultar en variados signos y síntomas en pacientes vulnerables al síndrome de salida torácica. La proximidad de los músculos escalenos con el plexo braquial, arteria y vena suclavias, coexistiendo con fascículos aberrantes pueden predisponer a síndromes de compresión.

Presence of additional muscles in the pectoral region has often been reported. We report about the presence of Pectoralis Minimus muscle, in a male cadaver. It was present deep to the pectoralis major muscle and superomedial to the pectoralis minor muscle. The variant was closely related to the branches of thoracoacromial vessels where one of the branches was passing between the pectoralis minor muscle and the variant muscle. Hyperabduction of the arm may compress these vessels giving rise to certain vascular symptoms. Also these variations should be borne in mind during certain surgical procedures in the pectoral region.

Presencia de músculos supernumerarios en la región pectoral han sido reportados. En un cadáver de un hombre se describe la presencia de un músculo Pectoralis Minimus. El músculo se localizaba profundo al músculo pectoral mayor y superomedial al músculo pectoral menor. La variación se relacionaba con las ramas de los vasos toracoacromiales donde una de las ramas pasaba entre el músculo pectoral menor y la variación muscular. La hiperabducción del brazo puede comprimir estos vasos provocando síntomas vasculares. Estas variaciones se deben tener en cuenta durante los procedimientos quirúrgicos en la región pectoral.

INTRODUCTION: Methotrexate, a folate antagonist, is a mainstay treatment for childhood acute lymphoblastic leukemia. It is also widely used in a low dose formulation to treat patients with rheumatoid arthritis. In rats, methotrexate is known to induce micronuclei formation, leading to genetic damage, while vitamin A is known to protect against such methotrexate-induced genetic damage. Leucovorin (folinic acid) is generally administered with methotrexate to decrease methotrexate-induced toxicity. OBJECTIVES: We aimed to determine whether vitamin A and leucovorin differed in their capacity to prevent formation of methotrexate-induced micronuclei in rat bone marrow erythrocytes. The present study also aimed to evaluate the effect of combined treatment with vitamin A and leucovorin on the formation of methotrexate-induced micronuclei. METHODS: Male and female Wistar rats (n=8) were injected with 20 mg/kg methotrexate (single i.p. dose). The control group received an equal volume of distilled water. The third and fourth groups of rats received vitamin A (5000 IU daily dose for 4 successive days) and leucovorin (0.5 mg/kg i.p. dose for 4 successive days), respectively. The fifth and sixth groups of rats received a combination of vitamin A and a single dose of methotrexate and a combination of leucovorin and methotrexate, respectively. The last group of rats received a combination of leucovorin, vitamin A and single dose of methotrexate. Samples were collected at 24 hours after the last dose of the treatment into 5% bovine albumin. Smears were obtained and stained with May-Grunwald and Giemsa. One thousand polychromatic erythrocytes were counted per animal for the presence of micronuclei and the percentage of polychromatic erythrocyte was determined. RESULTS: Comparison of methotrexate-treated rats with the control group showed a significant increase in the percentage of cells with micronuclei and a significant decrease polychromatic erythrocyte percentage. Combined methotrexate and vitamin A therapy and combined methotrexate and leucovorin therapy led to significant decreases in the micronuclei percentage and an increase in polychromatic erythrocyte percentage when compared to rats treated with methotrexate alone. Leucovorin was found to be more effective than vitamin A against the formation of methotrexate-induced micronuclei. CONCLUSIONS: Both vitamin A and leucovorin provided significant protection against genetic damage induced by methotrexate.

Meckel's diverticulum is the most prevalent congenital anomaly of the gastrointestinal tract. It might remain completely asymptomatic or may mimic some disorders like Crohn's disease, Appendicitis and peptic ulcer diseases. A Meckel's diverticulum was found during routine dissection. A brief review of this anomaly, its embryological explanation, and probable clinical implications with its management is discussed in this report

El diverticulo de Meckel es la anomalía congénita más prevalente del tracto gastrointestinal. Puede ser un remanente totalmente asintomático o puede provocar algunos desórdenes como la enfermedades de Crohn, apendicitis y úlcera péptica. Un diverticulo de Meckel fue encontrado durante una disección de rutina. Una breve revisión de esta anomalía, su explicación embriológica y probables implicaciones clínicas fueron discutidas en este trabajo

This comprehensive anatomical study on bones and X-rays regarding pedicles of lumbar vertebrae was performed in two parts. In the first part of the present work direct gross measurements of 3 different diameters (v, d, and 1) of both the pedicles of LI to L5 vertebrae (200 male and 200 female) were recorded through sliding vernier caliper. In the second part plain anteroposterior radiographs of the lumbar spine from 500 individuals (250 males and 250 females) were collected, and divided in 6 age groups and 2 different diameters (t and h) were recorded. The minimum horizontal diameter (d) of both the pedicles increased from LI to L5. Whereas, the vertical height (v) of both the pedicles increased from LI to L2, decreased from L2 to L3 and increased from L3 to L5. The anteroposterior length (1) increased bilaterally from LI to L2 and decreased from L2 to L5. All the aforementioned parameters were greater in male than corresponding vertebrae of female. Same trends were confirmed by the radiological study. The maximum horizontal diameter (t) of pedicles on both sides of vertebrae was significantly greater in females in less than 20 years of subjects, due to early pubertal growth spurt, whereas it was significantly greater in males in rest of all the age groups at all segments of vertebral spine. The maximum vertical height (h) of both the pedicles was significantly greater in males of age groups greater than 30 years from LI to L5

Este estudio sobre huesos y radiografías del pedículo de las vértebras lumbares fue realizado en dos partes. En la primera se midieron directamente con un caliper, 3 parámetros (v, d, y 1) en los pedículos de Ll a L5 (200 casos de sexo femenino y 200 de sexo masculino). En la segunda parte, se recolectaron 500 radiografías anteroposteriores (250 de hombres y 250 de mujeres) y se dividieron en 6 grupos etarios, registrándose dos diferentes diámetros (t y h). El diámetro horizontal menor se incrementó de Ll a L5 mientras que la altura vertical (v) de ambos pedículos de Ll a L2, decreció de L2 a L3 y se incrementó de L3 a L5. La longitud anteroposterior (1) se incrementó bilateralmente de Ll a L2 y decreció de L2 a L5. Todos los parámetros mencionados fueron mayores en el hombre que en la mujer. Los mismos se confirmaron en el estudio radiográfico. El diámetro horizontal máximo (t) de los pedículos de ambos lados fue significativamente mayor en mujeres con menos de 20 años debido a un temprano crecimiento acelerado en la pubertad mientras que, fue significativamente mayor en los hombres en todos los grupos etarios, en la totalidad de las vértebras. La altura vertical máxima de ambos pedículos fue significativamente mayor en los hombres del grupo mayor de 30 años desde Ll a L5

During routine dissection in the Department of Anatomy following anatomical variations of phrenic nerve were observed on right side in the neck region of a middle aged cadaver. The phrenic nerve in its early course close to its origin was giving a communicating branch to C5 root of brachial plexus and at the level of the root of neck just before entering the thorax, the phrenic nerve was placed anterior to the subclavian vein. This unique case of phrenic nerve variation gains tremendous importance in context of subclavian vein cannulation, implanted venous access portals, and supraclavicular nerve block for regional anesthesia

Durante una disección de rutina en el Departamento de Anatomía, observamos una variación anatómica del nervio frénico en el lado derecho del cuello de un cadáver de mediana edad. El nervio frénico cercano próximo a su origen dio un ramo comunicante para la raíz C5 del plexo braquial. A nivel de la raíz del cuello, justo antes de entrar al tórax, el nervio frénico se colocaba anterior a la vena subclavia. Este caso único de variación del nervio frénico adquiere una gran importancia en caso de canulación de la vena subclavia, implantes venosos accesos portales, y bloqueo del nervio supraclavicular por anestesia regional