ABSTRACT Objective: Cardiovascular diseases represent the main cause of death in chronic kidney disease (CKD). We aimed to evaluate the prevalence and association of the hypertriglyceridemia-waist phenotype (HWP) and visceral adiposity index (VAI) with cardiometabolic risk factors (CR) in patients with CKD on hemodialysis (HD). Materials and methods: The study is based on a cross-sectional design with 265 HD patients in two cities in northeastern Brazil. The VAI was calculated considering the variables body mass index (BMI), waist circumference (WC), triglycerides (TG) and high density lipoprotein cholesterol (HDL-c). HWP was defined as the concomitant elevation of WC and TG. The Poisson Regression Model with robust variance estimation was adjusted considering a hierarchical approach for explanatory variables. Prevalence ratios (PR) were also estimated. The level of significance adopted was 5%. Results: In our study HWP and VAI prevalence’s were 29.82% and 58.49%, respectively. In the final model, there was an association between VAI and female gender (PR = 1.46; p < 0.0001) and high body fat (% BF) (PR = 1.33; p < 0.0019). HWP was associated with females (PR = 1.80; p = 0.002), alcohol consumption (PR = 1.58; p = 0.033), obesity (PR = 1.89; p = 0.0001), high %BF (PR = 1.76; p = 0.012) and reduced HDL-c (PR = 1.48; p = 0.035). Conclusion: The HWP stood out as the association with more CR factors, representing a promising method for tracking cardiometabolic risk in HD patients, mainly female.

SUMMARY OBJECTIVE: To evaluated calcification of the coronary arteries and its association with visceral fat and 25-hydroxyvitamin D (25(OH)D) serum levels. METHODS: A cross sectional study involving 140 individuals without any previous diagnosis of cardiovascular disease. A biochemical analysis of vitamin D serum levels was carried out, as well as computed tomography to measure coronary artery calcium score and visceral adipose tissue. RESULTS: The mean age of the individuals was 55.9 (±12.4). Coronary artery calcium was observed in 40.7% of the population. Vitamin D presented median serum levels of 30.4 ng/ml (IQ24.5–39.1), with 14,1 and 33.7% of the individuals presenting deficiency and insufficiency, respectively. In the univariate analysis, the calcium score was more prevalent in aged patients (p<0.01), in hypertensive individuals (p<0.01), in diabetics (p=0.02), and in those with a higher concentration of VAT (p=0.02). In the adjusted analysis, it was found that the highest concentration of VAT (OR: 4.0; 95%CI 1.4–11.7), hypertension (OR: 4.8; 95%CI 1.5–15.3), and age (OR: 10.4; 95%CI 3.9–27.6) were predictors of subclinical atherosclerosis, regardless of body mass index, diabetes, and 25OHD. CONCLUSIONS: Excess visceral fat was associated with subclinical atherosclerosis, regardless of other risk factors for cardiovascular disease. Serum levels of 25OHD were not associated with CAD in its early stages.

ABSTRACT Objective: evaluate the relationship between visceral/subcutaneous adipose tissue (VAT/SAT) and glomerular filtration rate (GFR). Methods: A case series study was conducted with 146 male and female adult outpatients at a hospital in Northeast Brazil. VAT and SAT were quantified using computed tomography and GFR was estimated using the formula proposed by the CKD Epidemiology Collaboration. The conceptual model also considered socio-demographic, clinical, anthropometric and lifestyle variables. Results: Females accounted for 71.9% of the sample and mean age was 52.5±13.2 years. Mean body mass index indicated obesity in both sexes (men:30.4±5.9 kg/m2; women: 31.6±6.1 kg/m2). For the same mean age and BMI, men had more VAT and a higher VAT/SAT ratio. Mean GFR was similar between sexes and within the normal range. Simple linear regression analysis revealed that 21.8% of the reduction in GFR in males could be explained by the VAT/SAT ratio (p=0.002). Among females, both VAT alone and the VAT/SAT ratio were predictors of GFR reduction (r2=4.8%, p=0.025 and r2=5.3%, p=0.019, respectively). Conclusion: Mean VAT and VAT/SAT ratio were compatible with abdominal obesity in both sexes and were related to a reduction in GFR.

RESUMEN Objetivo: Evaluar la relación entre el tejido adiposo visceral (TAV) y subcutáneo (TAS) con la tasa de filtración glomerular. Métodos: Estudio tipo serie de casos, en 146 pacientes adultos de ambos sexos, atendidos en un ambulatorio de un hospital de referencia en el Nordeste brasileño. El TAV y el TAS se cuantificaron por tomografía computadorizada y la tasa de filtración glomerular (TFG) estimada por la fórmula del grupo Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). El modelo conceptual también consideró variables sociodemográficas, clínicas, antropométricas y de estilo de vida. Resultados: Pacientes con edad promedio de 52,5 ± 13,2 años y el 71,9% de sexo femenino. El promedio del IMC en ambos sexos se encuentra en el rango de obesidad (hombres= 30,4 ± 5,9 kg/m2 vs mujeres= 31,6 ± 6,1 kg/m2). Para un mismo promedio de edad e IMC, los hombres presentaron mayor TAV y mayor razón TAV/TAS que las mujeres. El promedio de la TFG fue similar entre los sexos y se encuentra en el rango normal. A través de regresión lineal simple, se evidenció que, en el sexo masculino, la disminución de la TFG puede explicarse en el 21,8% por la razón TAV/TAS (p=0,002). En el sexo femenino, tanto el TAV aislado como la razón TAV/TAS fueron predictores de disminución de la TFG (r2= 4,8%; p=0,025 e r2= 5,3%; p=0,019), respectivamente. Conclusión: Se evidenciaron valores muy elevados de los parámetros antropométricos de obesidad abdominal y promedio de TAV y de la razón TAV/TAS compatible con obesidad visceral en ambos sexos, siendo que estos dos últimos parámetros estuvieron relacionados al descenso de la TFG.

Com o objetivo de estimar a prevalência de obesidade abdominal e avaliar os fatores associados em adultos do Estado de Pernambuco, Brasil, foi realizado, em 2006, um estudo transversal, de base populacional, envolvendo 1.580 indivíduos na faixa etária de 25-59 anos. A obesidade abdominal foi determinada pela circunferência da cintura ≥ 80cm para mulheres e ≥ 94cm para homens. O modelo conceitual considerou variáveis socioeconômicas, demográficas, reprodutivas e comportamentais. A prevalência de obesidade abdominal foi de 27,1% (IC95%: 23,8-30,7) no sexo masculino e 69,9% (IC95%: 66,8-72,8) no feminino (p < 0,001). A análise ajustada revelou maior prevalência em homens a partir de 50 anos, da região metropolitana, de maior renda, ex-fumantes e consumidores de bebidas alcoólicas. Entre as mulheres, foi mais prevalente a partir de 30 anos, em ex-fumantes e naquelas com a primeira gestação antes de 18 anos. Fica evidente a gravidade e a multifatorialidade do problema da adiposidade central no Estado de Pernambuco, além de ser possível destacar que os determinantes da obesidade são diferentes entre os sexos.

In order to estimate the prevalence of abdominal obesity and associated factors in Pernambuco State, Brazil, a cross-sectional population-based study was conducted in 2006, including 1,580 adults 25 to 59 years of age. Abdominal obesity was defined as waist circumference (WC) ≥ 80cm in women and ≥ 94cm in men. The conceptual model included demographic, socioeconomic, reproductive, and behavioral variables. Prevalence of abdominal obesity was 27.1% (95%CI: 23.8-30.7) in males and 69.9% (95%CI: 66.8-72.8) in females (p < 0.001). Multivariate analysis showed higher prevalence in men 50 years or older in the metropolitan area and those with higher income, former smokers, and drinkers. Among women, obesity was more prevalent above 30 years of age, in former smokers, and in women with first pregnancy before age 18. Central adiposity is clearly a multifactor condition in the State of Pernambuco, and the determinants of obesity differ between the sexes.

Con el objetivo de estimar la prevalencia de obesidad abdominal y evaluar los factores asociados en adultos del estado de Pernambuco, Brasil, se realizó, en 2006, un estudio transversal, de base poblacional, involucrando a 1.580 individuos en una franja de edad de 25-59 años. La obesidad abdominal fue determinada por la circunferencia de la cintura ≥ 80cm para mujeres y ≥ 94cm para hombres. El modelo conceptual consideró variables socioeconómicas, demográficas, reproductivas y de comportamiento. La prevalencia de obesidad abdominal fue de un 27,1% (IC95%: 23,8-30,7) en el sexo masculino y un 69,9% (IC95%: 66,8-72,8) en el femenino (p < 0,001). El análisis ajustado reveló mayor prevalencia en hombres a partir de 50 años, de la región metropolitana, de mayor renta, ex-fumadores y consumidores de bebidas alcohólicas. Entre las mujeres, fue más prevalente a partir de 30 años, en ex-fumadoras y en aquellas con la primera gestación antes de los 18 años. Es evidente la gravedad y la multifactorialidad del problema de la adiposidad central en el estado de Pernambuco, además de ser destacable que los determinantes de la obesidad son diferentes entre los sexos.

Com o objetivo de estimar a prevalência de obesidade abdominal e avaliar os fatores associados em adultos do Estado de Pernambuco, Brasil, foi realizado, em 2006, um estudo transversal, de base populacional, envolvendo 1.580 indivíduos na faixa etária de 25-59 anos. A obesidade abdominal foi determinada pela circunferência da cintura ≥ 80cm para mulheres e ≥ 94cm para homens. O modelo conceitual considerou variáveis socioeconômicas, demográficas, reprodutivas e comportamentais. A prevalência de obesidade abdominal foi de 27,1% (IC95%: 23,8-30,7) no sexo masculino e 69,9% (IC95%: 66,8-72,8) no feminino (p < 0,001). A análise ajustada revelou maior prevalência em homens a partir de 50 anos, da região metropolitana, de maior renda, ex-fumantes e consumidores de bebidas alcoólicas. Entre as mulheres, foi mais prevalente a partir de 30 anos, em ex-fumantes e naquelas com a primeira gestação antes de 18 anos. Fica evidente a gravidade e a multifatorialidade do problema da adiposidade central no Estado de Pernambuco, além de ser possível destacar que os determinantes da obesidade são diferentes entre os sexos.

In order to estimate the prevalence of abdominal obesity and associated factors in Pernambuco State, Brazil, a cross-sectional population-based study was conducted in 2006, including 1,580 adults 25 to 59 years of age. Abdominal obesity was defined as waist circumference (WC) ≥ 80cm in women and ≥ 94cm in men. The conceptual model included demographic, socioeconomic, reproductive, and behavioral variables. Prevalence of abdominal obesity was 27.1% (95%CI: 23.8-30.7) in males and 69.9% (95%CI: 66.8-72.8) in females (p < 0.001). Multivariate analysis showed higher prevalence in men 50 years or older in the metropolitan area and those with higher income, former smokers, and drinkers. Among women, obesity was more prevalent above 30 years of age, in former smokers, and in women with first pregnancy before age 18. Central adiposity is clearly a multifactor condition in the State of Pernambuco, and the determinants of obesity differ between the sexes.

Con el objetivo de estimar la prevalencia de obesidad abdominal y evaluar los factores asociados en adultos del estado de Pernambuco, Brasil, se realizó, en 2006, un estudio transversal, de base poblacional, involucrando a 1.580 individuos en una franja de edad de 25-59 años. La obesidad abdominal fue determinada por la circunferencia de la cintura ≥ 80cm para mujeres y ≥ 94cm para hombres. El modelo conceptual consideró variables socioeconómicas, demográficas, reproductivas y de comportamiento. La prevalencia de obesidad abdominal fue de un 27,1% (IC95%: 23,8-30,7) en el sexo masculino y un 69,9% (IC95%: 66,8-72,8) en el femenino (p < 0,001). El análisis ajustado reveló mayor prevalencia en hombres a partir de 50 años, de la región metropolitana, de mayor renta, ex-fumadores y consumidores de bebidas alcohólicas. Entre las mujeres, fue más prevalente a partir de 30 años, en ex-fumadoras y en aquellas con la primera gestación antes de los 18 años. Es evidente la gravedad y la multifactorialidad del problema de la adiposidad central en el estado de Pernambuco, además de ser destacable que los determinantes de la obesidad son diferentes entre los sexos.

Com o objetivo de avaliar a magnitude do excesso de peso e fatores associados em adultos do Estado de Pernambuco, Brasil, foi realizado estudo transversal, de base populacional, em 2006, envolvendo 1.580 adultos, na faixa etária de 25-59 anos. O excesso de peso foi determinado pelo índice de massa corporal > 25kg/m². O modelo conceitual considerou variáveis socioeconômicas/demográficas, reprodutivas e comportamentais. A prevalência de excesso de peso foi de 51,1% (IC95%: 48,6-53,6). A análise multivariada mostrou que o excesso de peso foi maior a partir de 40 anos (RP = 1,27; IC95%: 1,10-1,46), em mulheres (RP = 1,29; IC95%: 1,16-1,43), em ex-fumantes (RP = 1,42; IC95%: 1,20-1,69), em indivíduos com maior renda (RP = 1,49; IC95%: 1,30-1,71) e em mulheres com primeira gestação com idade < 18 anos (RP = 1,25; IC95%: 1,11-1,66). Não houve associação com o consumo de álcool, com a atividade física e com o consumo alimentar. A expressiva prevalência do excesso de peso corrobora os níveis epidêmicos que este problema tem assumido em todo o mundo e a associação com vários fatores e reforçam a multifatorialidade de sua etiologia.

In order to evaluate the prevalence of overweight and associated factors in Pernambuco State, Brazil, a cross-sectional population-based study was conducted in 2006, including 1,580 adults 25 to 59 years of age. Overweight was defined as body mass index > 25kg/m2. The conceptual model included demographic, socioeconomic, reproductive, and behavioral variables. Prevalence of overweight was 51.1% (95%CI: 48.6-53.6) and was statistically associated with age over 40 years (PR = 1.27; 95%CI: 1.10-1.46), female gender (PR = 1.29; 95%CI: 1.16-1.43), former smoking (PR = 1.42; 95%CI: 1.20-1.69), higher income (PR = 1.49; 95%CI: 1.30-1.71), and history of early pregnancy (< 18 years) (PR = 1.25; 95%CI: 1.11-1.66). There was no association with alcohol consumption, level of physical activity, or specific foods. The high prevalence of overweight is consistent with epidemic levels of this problem elsewhere in world, and the association with several factors supports its multifactor etiology.

Com o objetivo de avaliar a magnitude do excesso de peso e fatores associados em adultos do Estado de Pernambuco, Brasil, foi realizado estudo transversal, de base populacional, em 2006, envolvendo 1.580 adultos, na faixa etária de 25-59 anos. O excesso de peso foi determinado pelo índice de massa corporal > 25kg/m². O modelo conceitual considerou variáveis socioeconômicas/demográficas, reprodutivas e comportamentais. A prevalência de excesso de peso foi de 51,1% (IC95%: 48,6-53,6). A análise multivariada mostrou que o excesso de peso foi maior a partir de 40 anos (RP = 1,27; IC95%: 1,10-1,46), em mulheres (RP = 1,29; IC95%: 1,16-1,43), em ex-fumantes (RP = 1,42; IC95%: 1,20-1,69), em indivíduos com maior renda (RP = 1,49; IC95%: 1,30-1,71) e em mulheres com primeira gestação com idade < 18 anos (RP = 1,25; IC95%: 1,11-1,66). Não houve associação com o consumo de álcool, com a atividade física e com o consumo alimentar. A expressiva prevalência do excesso de peso corrobora os níveis epidêmicos que este problema tem assumido em todo o mundo e a associação com vários fatores e reforçam a multifatorialidade de sua etiologia.

In order to evaluate the prevalence of overweight and associated factors in Pernambuco State, Brazil, a cross-sectional population-based study was conducted in 2006, including 1,580 adults 25 to 59 years of age. Overweight was defined as body mass index > 25kg/m2. The conceptual model included demographic, socioeconomic, reproductive, and behavioral variables. Prevalence of overweight was 51.1% (95%CI: 48.6-53.6) and was statistically associated with age over 40 years (PR = 1.27; 95%CI: 1.10-1.46), female gender (PR = 1.29; 95%CI: 1.16-1.43), former smoking (PR = 1.42; 95%CI: 1.20-1.69), higher income (PR = 1.49; 95%CI: 1.30-1.71), and history of early pregnancy (< 18 years) (PR = 1.25; 95%CI: 1.11-1.66). There was no association with alcohol consumption, level of physical activity, or specific foods. The high prevalence of overweight is consistent with epidemic levels of this problem elsewhere in world, and the association with several factors supports its multifactor etiology.