ABSTRACT BACKGROUND: Specific types of violence such as intimate partner sexual violence and intimate partner homicide occur more frequently in rural areas. OBJECTIVE: This study aimed to systematically review the literature on the knowledge and attitudes of rural healthcare providers regarding cases of domestic violence against women. DESIGN AND SETTING: Systematic review developed at Universidade Federal de Uberlândia. METHODS: We conducted an electronic search of six databases, which only included observational studies, regardless of the year, language, or country of publication, except for studies that used secondary data and were exclusively qualitative. Two reviewers performed the selection, data extraction, and risk of bias assessment using a specific Joanna Briggs Institute tool. RESULTS: Six studies met the inclusion criteria. All the studies had a low risk of bias. Approximately 38% of these professionals identified injuries caused by violence in patients. When asked about knowing the correct attitude to take in cases of confirmed violence, between 12% and 64% of rural healthcare providers answered positively; most of them would refer to specialized institutions and promote victim empowerment and counseling. The number of professionals with an educational background in the field ranged from 16% to 98%. CONCLUSIONS: The evident disparity across studies shows that some professionals have suboptimal knowledge and require training to adopt the correct attitude when identifying female victims of domestic violence in clinical practice. SYSTEMATIC REVIEW REGISTRATION: This systematic review was registered in the Open Science Framework Database under the registration http://doi.org/10.17605/OSF.IO/B7Q6S. BACKGROUND areas OBJECTIVE women SETTING Uberlândia METHODS databases year language publication qualitative selection extraction tool RESULTS criteria 38 patients 12 64 positively counseling 16 98 98% CONCLUSIONS practice REGISTRATION http//doi.org/10.17605/OSF.IO/B7Q6S. httpdoiorg1017605OSFIOB7Q6S httpdoiorgOSFIOBQS http //doi.org/10.17605/OSF.IO/B7Q6S. doi org 10 17605 OSF IO B7Q6S B Q S http://doi.org/10.17605/OSF.IO/B7Q6S 3 1 6 9 http//doi.org/10.17605/OSF.IO/B7Q6S httpdoiorg OSFIOB doiorg1017605OSFIOB7Q6S doiorgOSFIOBQS //doi.org/10.17605/OSF.IO/B7Q6S 1760 BQS doiorg 176 17

Abstract To plan and evaluate public health policies, it is important to understand the influence of social factors on the quality and access to dental care. This study aimed to verify the potential association between the indicators of pregnant women receiving dental care and the social and health care indicators of cities in the Brazilian state of Minas Gerais. A cross-sectional ecological study was performed with secondary data from the Brazilian Institute of Geography and Statistics and the Health Care Department of the Ministry of Health regarding the cities of Minas Gerais. The study analyzed three health care indicators (such as more than six prenatal, the proportion of syphilis and human immunodeficiency virus tests, and oral health coverage) and four social indicators (average monthly wage, illiteracy rate, proportion of employed population, and rate of adequate sanitary sewerage). Bivariate analysis (Mann-Whitney test) and logistic regression were performed using Jamovi software. All of the indicators analyzed were associated with the access of pregnant women to dental care. However, in the regression models, only health care indicators remained statistically significant. Thus, although social indicators are associated with the access of pregnant women to dental appointments, access to primary health care and the teamwork of primary health care teams may overcome social inequality in the access of pregnant women to dental care. policies Gerais crosssectional cross sectional such prenatal tests coverage average wage population sewerage. sewerage . sewerage) MannWhitney Mann Whitney test software However models significant Thus appointments

ABSTRACT BACKGROUND: Adolescence is characterized by complex and dynamic changes, often involving experimentation, including the use of psychotropic substances. Although it is well-established that recreational psychotropic drugs are associated with suicide ideation in adults, evidence of this association in adolescents remains limited. OBJECTIVE: To investigate the relationship between suicide ideation and psychotropic recreational drug use among adolescents. DESIGN AND SETTING: Systematic review with meta-analysis developed at Universidade Federal de Uberlândia (UFU) and Universidade Estadual de Campinas (UNICAMP), Brazil. METHODS: A search across eight electronic databases for observational studies, without language or publication year restrictions, was conducted. The Joanna Briggs Institute tool was used to assess the risk of bias. Random-effects meta-analyses and odds ratios were used to measure the effects. RESULTS: The search yielded 19,732 studies, of which 78 were included in the qualitative synthesis and 32 in the meta-analysis. The findings indicated that suicidal ideation was 1.96 times more likely (95% confidence interval, CI = 1.47; 2.61) for adolescents who used some drug recurrently and 3.32 times more likely (95%CI = 1.86; 5.93) among those who abused drugs. Additionally, adolescents who used cannabis were 1.57 times more likely (95%CI = 1.34; 1.84) to experience suicide ideation compared with non-users, while cocaine users had 2.57 times higher odds (95%CI = 1.47; 4.50). CONCLUSIONS: Psychotropic recreational drug use is associated with suicidal ideation among adolescents regardless of current or previous use, abuse, or type of substance used. SYSTEMATIC REVIEW REGISTRATION: Registered in the PROSPERO database under the identification number CRD42021232360. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021232360. BACKGROUND changes experimentation substances wellestablished well established adults limited OBJECTIVE SETTING metaanalysis meta analysis UFU (UFU UNICAMP, UNICAMP , (UNICAMP) Brazil METHODS studies restrictions conducted bias Randomeffects Random effects metaanalyses analyses RESULTS 19732 19 732 19,73 7 3 metaanalysis. analysis. 196 1 96 1.9 95% 95 (95 interval 1.47 147 47 2.61 261 2 61 332 3.3 95%CI 95CI 1.86 186 86 5.93 593 5 93 Additionally 157 57 1.5 1.34 134 34 1.84 184 84 nonusers, nonusers non users, non-users 257 2.5 4.50. 450 4.50 . 4 50 4.50) CONCLUSIONS abuse REGISTRATION CRD42021232360 CRD https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD42021232360. httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD42021232360 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD https //www.crd.york.ac.uk/prospero/display_record.php ID=CRD42021232360. www crd york ac uk prospero display record php ID https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021232360 (UNICAMP 1973 73 19,7 9 1. (9 1.4 14 2.6 26 6 33 3. 1.8 18 8 5.9 59 15 1.3 13 25 2. 45 4.5 CRD4202123236 phpID https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD42021232360 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD4202123236 wwwcrdyorkacukprosperodisplayrecordphp IDCRD42021232360 IDCRD ID=CRD42021232360 https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD4202123236 197 19, ( 5. 4. 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Resumo Objetivo Verificar a existência de relação entre a atenção odontológica à gestante e as condições bucais maternas e de saúde do recém-nascido. Material e método Realizou-se um estudo transversal com puérperas identificadas em uma maternidade no estado de Minas Gerais, em que foram coletados dados de atenção odontológica durante a gestação, condições de saúde bucal materna, Índice de Apgar do recém-nascido e variáveis de confundimento. Os dados foram analisados inicialmente de forma descritiva e a correlação entre a atenção odontológica e o Índice de Apgar foi testada por meio do teste de Pearson. Resultado Foram analisados os dados coletados das 144 puérperas e seus bebês, mas não foram encontradas correlações entre o Índice de Apgar e nenhuma das variáveis de cuidado odontológico, variáveis maternas e do recém-nascido coletadas no estudo. Conclusão Não foram observadas correlações do Índice de Apgar com nenhuma variável de cuidado odontológico, variáveis maternas e do recém-nascido. recémnascido. recémnascido recém nascido. nascido Realizouse Realizou se Gerais gestação materna confundimento Pearson 14 bebês odontológico 1

Abstract Aim To verify the existence of a relationship between dental care for pregnant women and maternal oral conditions and the health of the newborn. Material and method A cross-sectional study was carried out with mothers identified in a maternity hospital in the state of Minas Gerais, in which data on dental care during pregnancy, maternal oral health conditions, Apgar score of the newborn and confounding variables were collected. The data were initially analyzed descriptively and the adaptation between dental care and the Apgar score was tested using the Pearson test. Result Data collected from 144 postpartum women and their babies were analyzed, but no correlations were found between the Apgar score and any of the dental care, maternal and newborn variables collected in the study. Conclusion No correlations of the Apgar Score with any dental care variables, maternal and newborn variables were observed. crosssectional cross sectional Gerais pregnancy test 14 observed 1

Abstract Background Local anesthetic puncture is often related to the experience of pain. This study aimed to systematically analyze the literature on changes in pain perception during the anesthetic puncture of dental local anesthesia after Photobiomodulation Therapy (PBMT). Material and methods An electronic search was performed in eight primary databases (Embase, LILACS, BBO, LIVIVO, MedLine via PubMed, SciELO, Scopus, and Web of Science) and three additional ones (EASY, Google Scholar, and OATD) to partially capture the “gray literature”. The PICO strategy was used to identify randomized clinical trials evaluating the analgesic effect of PBMT in the anesthetic puncture site of dental local anesthesia compared to placebo or control groups, without restrictions on publication language and year. Two reviewers extracted the data and assessed the individual risk of bias of the eligible studies using the Cochrane Collaboration Risk of Bias Tool version 2.0. Results The electronic search found 3,485 records, of which eight met the eligibility criteria and were included in the qualitative synthesis. The studies were published from 2011 to 2022. None of the included studies had a low risk of bias. PBMT groups showed no significant difference in pain scores compared to placebo and control groups of most studies. Conclusion Based on a low to very low certainty of evidence, PBMT seems to have no effect on pain perception during anesthetic puncture in patients undergoing dental local anesthesia. PBMT. . (PBMT) Embase, Embase (Embase LILACS BBO LIVIVO PubMed SciELO Scopus Science EASY, EASY (EASY Scholar OATD gray literature. literature” year 20 2 0 2.0 3485 3 485 3,48 records synthesis 201 2022 evidence (PBMT 2. 348 48 3,4 202 34 4 3,

Abstract Civil and criminal forensics utilize dental development to estimate age. The method of Nicodemo, Moraes, and Médici Filho (NMM) is a popular dental age estimation tool in South America; however, it lacks a scientific basis for applications in contemporary forensic practice. This research included the largest sample ever collected in Brazil for a similar purpose. The sample consisted of 3,271 panoramic radiographs of female (n = 1,634) and male (n = 1,637) individuals between six and 22.9 years old (mean 14.6 ± 4.9 years). The applied NMM method considered all maxillary and mandibular left permanent teeth (n = 16). The fit between the chronological age and estimated age intervals was assessed, and a correlation test with Lin's correlation coefficient was performed. The overall percentage of fit was 22.5%, without statistically significant differences based on sex (p > 0.05). The percentage of fit was greater in younger individuals, such as those aged 6–6.99 years (90%), and progressively decreased in older individuals, such as those aged 11–11.9 years (18.2%). After 12 years of age, the method could not provide correct classifications up to 25 years of age. Lin's correlation coefficient was predominantly low (ρ = 0.175; 0.367). NMM is considerably limited, and current forensic practice should not apply it to estimate dental age. Nicodemo Moraes (NMM America however purpose 3271 3 271 3,27 n 1,634 1634 1 634 1,637 1637 637 229 22 9 22. mean 146 14 6 14. 49 4 4. years. . years) 16. 16 16) assessed Lins Lin s performed 225 5 22.5% p 0.05. 005 0.05 0 05 0.05) 6699 99 6–6.9 90%, 90 90% , (90%) 11119 11 11–11. 18.2%. 182 18.2% 18 2 (18.2%) ρ 0.175 0175 175 0.367. 0367 0.367 367 0.367) limited 327 27 3,2 1,63 163 63 22.5 00 0.0 669 6–6. (90% 1111 11–11 18.2 (18.2% 0.17 017 17 036 0.36 36 32 3, 1,6 0. 66 6–6 (90 111 11–1 18. (18.2 0.1 01 03 0.3 1, 6– (9 11– (18. ( (18 (1

Abstract This systematic review aims to provide preclinical evidence of the antimicrobial efficacy of natural endodontic solutions (NES) compared to sodium hypochlorite (NaOCl) and chlorhexidine (CHX) against Enterococcus faecalis. The study followed the PRISMA guidelines and had a registered protocol (PROSPERO – CRD42021224022). The inclusion criteria comprised ex vivo studies simulating root canal irrigation to assess the standardized mean difference of colony-forming units (CFUs). Records were systematically identified in PubMed, Scopus, EMBASE, SciELO, Web of Science, LILACS, DANS Easy, and BDTD databases in January 2024. The RoBDEMAT tool helped determine the risk of bias. As for the network meta-analysis, CFU data were collected pre- and post-irrigation protocols as an effect measure. Thirty-five studies met the eligibility criteria and were included in the qualitative analysis, and seven studies were eligible for the network meta-analysis. The total sample consisted of 1,504 root canals. Among the tested solutions, apple cider vinegar combined with 2.5% NaOCl showed the highest probability of reducing CFUs after root canal irrigation (95%CI: -0.76–0.20), followed by 2% CHX and NaOCl (considering the different concentrations [95%CI: -0.32–0.17]). The bias assessment revealed significant omissions in reporting, particularly regarding sample size calculation, sample randomization, and operator blinding. The obtained evidence demonstrated that, even though NES did not overcome NaOCl, they have antimicrobial potential against Enterococcus faecalis. (NES (NaOCl (CHX faecalis PROSPERO CRD42021224022. CRD42021224022 CRD . CRD42021224022) colonyforming colony forming CFUs. (CFUs) PubMed Scopus EMBASE SciELO Science LILACS Easy 2024 metaanalysis, metaanalysis meta analysis meta-analysis pre postirrigation post measure Thirtyfive Thirty five metaanalysis. analysis. 1504 1 504 1,50 canals 25 2 5 2.5 95%CI 95CI CI 95 (95%CI 0.76–0.20, 076020 0.76–0.20 , 0 76 20 -0.76–0.20) considering [95%CI 0.32–0.17. 032017 0.32–0.17 32 17 -0.32–0.17]) reporting calculation randomization blinding that CRD4202122402 (CFUs 202 150 50 1,5 2. 9 07602 0.76–0.2 7 -0.76–0.20 03201 0.32–0.1 3 -0.32–0.17] CRD420212240 15 1, 0760 0.76–0. -0.76–0.2 0320 0.32–0. -0.32–0.17 CRD42021224 076 0.76–0 -0.76–0. 032 0.32–0 -0.32–0.1 CRD4202122 07 0.76– -0.76–0 03 0.32– -0.32–0. CRD420212 0.76 -0.76– 0.32 -0.32–0 CRD42021 0.7 -0.76 0.3 -0.32– CRD4202 0. -0.7 -0.32 CRD420 -0. -0.3 CRD42 -0 CRD4 -

RESUMO Objetivo: Esta revisão sistemática teve como objetivo analisar a literatura sobre alterações em biomarcadores salivares endógenos de dor, ansiedade, estresse e inflamação relacionados à movimentação dentária durante tratamento ortodôntico de crianças e adolescentes. Material e Métodos: Foram realizadas buscas eletrônicas em nove bases de dados para identificar estudos quase-experimentais sobre o tema, sem restrições de idioma e ano de publicação. Dois revisores extraíram os dados e avaliaram o risco individual de viés usando as ferramentas JBI, e a certeza da evidência usando a ferramenta GRADE. Resultados: A busca eletrônica encontrou 7.038 registros, dos quais 12 atenderam aos critérios de elegibilidade e foram incluídos na síntese qualitativa. A maioria dos estudos apresentou baixo risco de viés. Os biomarcadores foram agrupados em cinco categorias: eletrólitos, enzimas, hormônios, imunoglobulinas e mediadores. Os eletrólitos apresentaram diminuição dos níveis de Ca2+, Pi3+ e K+ e aumento dos níveis de Na+ e Cl-. Todas as enzimas (ALP, LDH, MMP8 e MMP9) aumentaram ao longo do tempo. Os hormônios apresentaram diminuição da leptina e algumas oscilações nos níveis diários de cortisol. As imunoglobulinas (IgA, IgG, IgM, IgD e IgE) não tiveram alterações significativas, e a IgA salivar apresentou resultados divergentes entre os estudos. Os mediadores (sRANKL, OPG, IL-1β e PGE2) apresentaram flutuações nas diferentes fases do tratamento, principalmente após a ativação ortodôntica. Conclusões: Com base em um nível de certeza muito baixo, a movimentação dentária ortodôntica teve pouco ou nenhum efeito sobre biomarcadores salivares endógenos. Objetivo dor ansiedade adolescentes Métodos quaseexperimentais quase experimentais tema publicação JBI GRADE Resultados 7038 7 038 7.03 registros 1 qualitativa categorias Ca2 Ca Ca2+ Pi3 Pi K Na Cl. Cl . Cl- ALP, ALP (ALP LDH MMP MMP9 tempo cortisol IgA, (IgA IgG IgM IgE significativas sRANKL, sRANKL (sRANKL OPG IL1β ILβ IL 1β β PGE2 PGE Conclusões 703 03 7.0 70 0 7.

ABSTRACT Objective: This systematic review aimed to analyze the literature on changes in endogenous salivary biomarkers of pain, anxiety, stress, and inflammation related to tooth movement during orthodontic treatment of children and adolescents. Material and Methods: An electronic search was performed in nine databases to identify quasi-experimental studies, without restricting publication language and year. Two reviewers extracted the data and assessed the individual risk of bias using the JBI tools, and the certainty of evidence using the GRADE tool. Results: The electronic search found 7,038 records, of which 12 met the eligibility criteria and were included in the qualitative synthesis. Most studies had a low risk of bias. Biomarkers were grouped into five categories: electrolytes, enzymes, hormones, immunoglobulins, and mediators. Electrolytes showed decreased Ca2+, Pi3+ and K+ levels, and increased Na+ and Cl- levels. All enzymes (ALP, LDH, MMP8, and MMP9) increased over time. Hormones presented a decrease in leptin and some fluctuations in daily cortisol levels. Immunoglobulins (IgA, IgG, IgM, IgD, and IgE) had no significant changes, and salivary IgA showed divergent results among studies. Mediators (sRANKL, OPG, IL‐1β, and PGE2) showed fluctuations at different treatment stages, mainly after orthodontic activation. Conclusions: Based on a very low certainty level, orthodontic tooth movement had little to no effect on endogenous salivary biomarkers. Objective pain anxiety stress adolescents Methods quasiexperimental quasi experimental year tools tool Results 7038 7 038 7,03 records 1 synthesis categories electrolytes hormones immunoglobulins mediators Ca2 Ca Ca2+ Pi3 Pi K levels Na Cl ALP, ALP (ALP LDH MMP8 MMP MMP9 time IgA, (IgA IgG IgM IgD IgE sRANKL, sRANKL (sRANKL OPG IL1β ILβ IL 1β β IL‐1β PGE2 PGE stages activation Conclusions level 703 03 7,0 70 0 7,

Abstract This study aimed to assess the potential association between perception malocclusion and school performance in children and adolescents. An electronic search was performed in ten databases. Based on the PECO acronym (Population, Exposition, Comparator, and Outcome), the eligibility criteria included observational studies that compared the school performance of children and adolescents with and without the perception of malocclusion. There were no restrictions on the language or year of publication. Two reviewers selected the studies, extracted the data, and assessed the risk of bias by using the Joanna Briggs Institute tool for cross-sectional studies. School performance was measured by analyzing student grades; levels of absenteeism; and child or adolescent self-perception and/or the perception of parents, guardians, close friends, and teachers regarding the impact of malocclusion on school performance. The data were described narratively/descriptively. The search resulted in 3,581 registers, of which eight were included in the qualitative synthesis. These studies were published between 2007 and 2021. Two studies concluded that there was no significant association between school performance and perception of malocclusion, five studies found that only some of the children with malocclusion had their school performance affected, and one study concluded that there was a significant association between perception of malocclusion and low school performance. Considering all variables and the very low certainty of evidence, the perception of malocclusion seems to negatively impact school performance when associated with external and subjective factors. Further studies using additional measurement standards are required. databases Population, Population (Population Exposition Comparator Outcome, Outcome , Outcome) publication crosssectional cross sectional grades absenteeism selfperception self andor parents guardians friends narrativelydescriptively narratively descriptively narratively/descriptively 3581 3 581 3,58 registers synthesis 200 2021 affected evidence factors required 358 58 3,5 20 202 35 5 3, 2

Abstract Lipolytic substance injections to reduce localized fat have been extensively used because it is a low-invasive method. This review aimed to evaluate the efficacy and safety of deoxycholic acid in submental fat reduction compared to a placebo and investigate the potential industry sponsorship bias in the results of randomized clinical trials on this topic. Ten electronic databases were extensively searched for randomized clinical trials without restriction on language and year of publication. Two reviewers extracted the data and assessed the individual risk of bias in the studies with the RoB 2.0 tool. The industry sponsorship bias was evaluated according to citations in the articles regarding industry funding/sponsorship throughout the texts. Fixed and random effects meta-analyses were performed, and the results were reported in Risk Ratio (RR) at a 95% Confidence Interval (95% CI). The initial search provided 5756 results, of which only five were included. Only two studies had a low risk of bias. All studies showed a potential industry bias. The meta-analysis showed that patients treated with deoxycholic acid had significant positive results for all efficacy outcomes and a higher risk of fibrosis, pain, erythema, numbness, swelling, edema, pruritus, nodules, headache, and paresthesia. The low to moderate certainty of evidence found allows concluding that deoxycholic acid is effective in submental fat reduction, causing well-tolerated adverse effects. However, all eligible studies showed a potential industry bias. lowinvasive invasive method topic publication 20 2 0 2. tool fundingsponsorship funding texts metaanalyses meta analyses performed RR (RR 95 (95 CI. CI . CI) 575 included metaanalysis analysis fibrosis pain erythema numbness swelling edema pruritus nodules headache paresthesia welltolerated well tolerated However 9 (9 57 ( 5

Abstract BACKGROUND: Chronically elevated alpha-2-macroglobulin (A2MG) in the blood has been correlated with diabetes and the HbA1c profile; however, no systematic review has been conducted to evaluate the association of A2MG salivary levels and glycemia or HbA1c levels in diabetes mellitus type 2 (DM2) patients. OBJECTIVE: To evaluate whether A2MG salivary levels are related to the glycemia or HbA1c levels in DM2 patients. DESIGN AND SETTING: Systematic review developed at Universidade Federal de Uberlândia (UFU), Brazil. METHODS: Eight databases were used as research sources. The eligibility criteria included studies that reported data regarding mean salivary A2MG and the correlation between glycemia and/or HbA1c levels of DM2 subjects (uncontrolled and well-controlled) and non-diabetic subjects. The risk of bias of the studies selected was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools for use in JBI systematic reviews. Pooled correlation coefficients were estimated using the Hunter-Schmidt method. Study estimates were weighted according to their sample size, and heterogeneity was calculated using the chi-square statistic. RESULTS: Four studies on DM2 patients were included in this systematic review after careful analysis of 1482 studies. Three studies compared A2MG with HbA1c and glycemia. Overall, the correlation between A2MG and HbA1c was strong (r = 0.838). In contrast, the correlation between A2MG and glycemia was low (r = 0.354). CONCLUSION: The strong association between HbA1C and salivary A2MG suggests that this salivary protein has the potential to be a surrogate for HbA1C, if corroboratory further evidence is obtained through large-scale studies.

Abstract This systematic review evaluated the potential utility of platelet-rich fibrin (PRF) in bone repair in animals. The question is: can the use of PRF in bone defects in healthy rats induce bone repair compared to clot? This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (Prisma). The protocol was registered with Prospero (CRD [42020162319]). The literature search involved nine databases, including grey literature. All studies evaluated the bone defects created in rats filled with PRF and clots (control). Biomaterial evaluation was also performed in this study. The risk of bias was assessed using the Systematic Review Center for Laboratory Animal Experimentation (Syrcle) tool for animal studies. A meta-analysis of quantitative data was performed to estimate the effect of PRF on bone repair in rats. Heterogeneity among the studies was assessed using the I2 statistic. The literature search retrieved 685 studies, 10 of which fulfilled the eligibility criteria, and 4 were included in the quantitative assessment. Analysis of the risk of bias revealed that most studies had a high risk of bias in performance and detection. Meta-analysis yielded divergent results and the absence of a statistically significant effect: PRF with control (standardized mean difference 2.54, 95% confidence interval -0.80–5.89; p = 0.14). In general, study heterogeneity was high (I2 ≥ 75.0%). The quality of the studies that influenced the conclusion of the review was based on the PICO, the sources and form of the search, the study selection criteria, the form of evaluation of publication bias, the evaluation of the quality of the studies, and data extraction by two researchers. PRF did not provide significant benefits for bone repair, resulting in unpredictable effects.

O estudo teve como objetivo analisar parte dos recursos utilizados para financiar ações de saúde pública nas 26 capitais brasileiras entre 2008 e 2018. O estudo ecológico de tendências temporais envolveu indicadores de receitas e gastos fornecidos pelo Sistema de Informação sobre Orçamento Público em Saúde (SIOPS). Os valores foram deflacionados com base no Índice de Preços ao Consumidor Amplo de 2018 no Brasil para permitir a comparação ao longo dos anos. A variação anual média dos investimentos em saúde, em Reais (BRL), foi avaliada com o uso de regressões lineares. Os coeficientes de correlação de Pearson foram estimados entre as receitas e gastos federais com os recursos das capitais. Todas as capitais apresentaram correlações estatisticamente positivas com a origem do recurso orçamentário investido em saúde. O menor coeficiente foi encontrado na cidade de Macapá (Amapá) (r = 0,860), e o mais alto em Fortaleza (Ceará) (r = 0.997). Belo Horizonte (Minas Gerais) foi a capital com o maior aumento anual em transferências federais (cerca de BRL 67,91 por ano) e Teresina (Piauí) apresentou o maior aumento anual nos gastos em saúde (cerca de BRL 55,42 por ano). Houve um aumento real nas transferências no Sistema Único de Saúde (SUS) e nos recursos municipais em quase todas as capitais, mas ainda persistem desigualdades na distribuição dos recursos financeiros entre as capitais brasileiras das cinco regiões. O financiamento da saúde é afetado pela municipalização do SUS, e não é o único fator que afeta o acesso e a qualidade dos serviços de saúde.

This study aimed to analyze part of the financial resources used to fund public health actions in the 26-Brazilian capitals, from 2008 to 2018. This is a time-trend ecological study involving revenue and expenditure indicators provided by the Information System on Public Budget for Health (SIOPS). The values were deflated based on the Extended National Consumer Price Index of 2018 in Brazil to allow the comparison over the years. The mean annual variation of health investments, in Brazilian Reais (BRL) was assessed using linear regressions. Pearson’s correlation coefficients were estimated between federal revenues and expenditures with the capitals’ resources. All capitals presented statistically significant positive correlations for the origin of the budget resource invested in health. The lowest coefficient was found in the capital city of Macapá (Amapá State) (r = 0.860) and the highest, in Fortaleza (Ceará State) (r = 0.997). Belo Horizonte (Minas Gerais State) was the capital with the highest annual increase in federal transfers (about BRL 67.91 per year) and Teresina (Piauí State) presented the highest annual increase in health expenditures among the capitals (about BRL 55.42 per year). We found a increase in the transfers of the Brazilian Unified National Health System (SUS) and municipal resources in almost all capitals, but there are still inequalities in the distribution of financial resources among Brazilian capitals from different regions. Health funding is affected by the municipalization of SUS and it is not the single factor affecting the access and quality of health services.

El objetivo fue analizar la parte de recursos financieros utilizados para financiar acciones de salud públicas en 26 capitales brasileñas, entre 2008 y 2018. Se trata de un estudio ecológico de tendencia temporal, implicando indicadores de ingresos y gastos proporcionados por el Sistema de Información sobre el Presupuesto Público para Salud (SIOPS). Se deflactaron los valores basados en el Índice de Precios al Consumidor, ampliado de 2018 en Brasil, para permitir la comparación a lo largo de los años. La variación anual media de inversiones en salud, en Reales brasileños (BRL), fue evaluada usando regresiones lineales. Se estimaron los coeficientes de correlación de Pearson entre los ingresos y gastos federales, respecto a los recursos de las capitales. Todas las capitales presentaron estadísticamente correlaciones positivas significativas respecto a la fuente presupuestaria originaria invertida en salud. El coeficiente más bajo se encontró en la capital de Macapá (Amapá) (r = 0.860) y el más alto en Fortaleza (Ceará) (r = 0.997). Belo Horizonte (Minas Gerais) fue la capital con el incremento anual más alto en transferencias federales (cerca de BRL 67.91 por año) y Teresina (Piauí) presentó el incremento anual más alto en gastos de salud entre todas las capitales (sobre BRL 55.42 por año). Hubo un incremento real de transferencias en el Sistema Único de Salud brasileño (SUS), así como recursos municipales en casi todas las capitales, pero existen todavía inequidades en la distribución de recursos financieros entre las capitales brasileñas de diferentes regiones. La financiación de la salud está afectada por la municipalización del SUS, y no es el único factor que afecta al acceso y calidad de los servicios de salud.

Abstract The aim of this scoping review was to provide sufficient information about the effectiveness of ozone gas in virus inactivation of surfaces and objects under different environmental conditions. The review was performed according to the list of PRISMA SrC recommendations and the JBI Manual for Evidence Synthesis for Scoping Reviews. The review was registered in Open Science Framework (OSF). EMBASE (Ovid), Lilacs, LIVIVO, MEDLINE (PubMed), SciELO, Scopus and Web of Science were primary sources, and “gray literature” was searched in OpenGray and OpenThesis. A study was included if it reported primary data on the effect of ozone gas application for vehicle-borne and airborne virus inactivation. No language or publication date restriction was applied. The search was conduct on July 1, 2020. A total of 16,120 studies were screened, and after exclusion of noneligible studies, fifteen studies fulfilled all selection criteria. Application of ozone gas varied in terms of concentration, ozone exposure period and the devices used to generate ozone gas. Twelve studies showed positive results for inactivation of different virus types, including bacteriophages, SARS-CoV-2 surrogates and other vehicle-borne viruses. Most of the studies were classified as unclear regarding sponsorship status. Although most of the population has not yet been vaccinated against COVID-19, disinfection of environments, surfaces, and objects is an essential prevention strategy to control the spread of this disease. The results of this Scoping Review demonstrate that ozone gas is promising for viral disinfection of surfaces.

Abstract Mucopolysaccharidosis (MPS) is a heterogeneous group of rare, chronic, progressive and systemic inherited disorders resulting from deficiency or lack of lysosomal enzymes responsible for the degradation of glycosaminoglycans. Products of nitrosative stress have been previously detected in blood and urine samples of patients with MPS. However, it is unclear whether they are present in the saliva of MPS patients and also if they correlate with salivary parameters such as flow and pH. This study compared the salivary levels of NOX (NO2- + NO3-), nitrite (NO2-), protein (albumin), erythrocyte and leukocyte numbers, as well as the salivary flow rate and pH values of samples obtained from 10 MPS patients and 10 healthy subjects. MPS patients exhibited higher salivary levels of NOX and NO2- when compared to healthy subjects (p < 0.05). Albumin was only detected in six saliva samples of MPS patients and, erythrocytes and leukocytes were detected in 60% and 40% of the MPS patients, respectively. In addition, salivary flow rate and pH averages were statistically lower in this group when compared to healthy samples (p < 0.05). Overall, the data indicates that the salivary levels of NO products can be used in combination with other heath indicators to monitor MPS disorders.