Abstract This paper aims to analyze the impact of lockdown on education in the context of social acceleration. In this paper, we address the necessary (re)construction required to enhance the education of adolescents. From this perspective, it examines the potential of the adolescent brain, as advocated by Daniel Siegel. The present study employs a bibliographical research methodology to investigate the impact of social acceleration on education in the aftermath of the lockdown. We emphasize that the adolescent phase is crucial for the development of potentials in the educational context. In this vein, a philosophical analysis of the school is conducted, highlighting it as a space for (re)constructing practices that encourage adolescents to listen to the world around them. Therefore, the school must illuminate the potential of adolescence, such as creativity and openness to novelty, as a space for (re)creating subjects in times of acceleration.

Resumo O presente trabalho tem como temática as consequências do lockdown na educação, considerando o contexto da aceleração social. Questiona-se, qual é a (re)construção necessária para a educação de adolescentes. Para tanto, analisa-se as potencialidades do cérebro adolescente defendidas por Daniel Siegel. O trabalho apresenta uma pesquisa bibliográfica, estruturada a partir de uma análise sobre a aceleração social e seus impactos educacionais após o lockdown. Entende-se que fase da adolescência é essencial para o desenvolvimento de potencialidades no contexto educacional. Sob tal perspectiva, desenvolve-se uma análise filosófica sobre a escola, apontando-a como um espaço de (re)construção de práticas que convidem os adolescentes a escutar o mundo. Portanto, a escola, como espaço de (re)criação dos sujeitos em tempos de aceleração deve estimular as potencialidades no período da adolescência, como a criatividade e a abertura para a novidade.

Resumen Este trabajo tiene como objetivo analizar el impacto del lockdown en la educación en el contexto de la aceleración social. En este trabajo, problematizamos la (re)construcción necesaria para potenciar la educación de los adolescentes. Desde esta perspectiva, se analiza el potencial del cerebro adolescente, como defiende Daniel Siegel. El presente estudio emplea una metodología de investigación bibliográfica para investigar el impacto de la aceleración social en la educación tras el lockdown. Señalamos que la fase de la adolescencia es crucial para el desarrollo de las potencialidades en el contexto educativo. En este sentido, se realiza un análisis filosófico de la escuela, destacándola como espacio de (re)construcción de prácticas que estimulen a los adolescentes a escuchar el mundo que los rodea. Por lo tanto, la escuela debe iluminar las potencialidades de la adolescencia, como la creatividad y la apertura a la novedad, como espacio de (re)creación de sujetos en tiempos de aceleración.

Resumo O estudo investiga o impacto do intercruzamento de raça/cor, escolaridade e local de residência na não adequação do cuidado prestado em diferentes dimensões do pré-natal. Para tal, analisaram-se dados da Pesquisa Nacional de Saúde de 2013 com modelos de regressão logística múltipla. Os resultados sugerem que as variáveis operam em conjunto na não adequação ao pré-natal. As mulheres negras e as menos escolarizadas apresentaram maior probabilidade de não ter 6 consultas de pré-natal, iniciadas antes da 12ª semana de gestação. Mulheres de até 20 anos de idade, residentes nas regiões Norte, Nordeste e Centro-Oeste e menos escolarizadas foram menos submetidas aos exames laboratoriais e físicos preconizados. E, por último, mulheres negras e de até 20 anos de idade foram mais propensas a não receber orientações sobre o parto. Os achados reiteram a natureza multifacetada do problema e alertam para a insuficiência dos inquéritos populacionais, ao não incluir e não permitir a caracterização dos segmentos mais marginalizados da população, dificultando a investigação de realidades segundo uma perspectiva interseccional. raçacor raça cor raça/cor prénatal. prénatal pré natal. natal pré-natal tal analisaramse analisaram se 201 múltipla prénatal, natal, ª gestação 2 Norte CentroOeste Centro Oeste preconizados E último parto populacionais população interseccional

Abstract The present study investigates the intersecting impacts of race/color, education and place of residence on the non-adequacy of care provided in different dimensions of prenatal care. To this end, we analyzed data from the 2013 National Health Survey using multiple logistic regression models. The results suggest that the variables operate together to shape non-adequacy to prenatal care. Black women and those with less schooling were more likely to miss 6 prenatal consultations, starting before the 12th week of pregnancy. Women up to 20 years of age, those residing in the North, Northeast and Midwest regions and those with less schooling were less submitted to the recommended laboratory and physical exams. And, finally, black women and those up to 20 years of age were more likely to not receive guidance on childbirth. Our findings reiterate the multifaceted nature of the problem and point to the insufficiency of population surveys, by not including and not allowing the characterization of the most marginalized segments of the population, making it difficult to further investigate realities from an intersectional perspective. racecolor race color race/color nonadequacy non adequacy end 201 models consultations th pregnancy 2 North exams And finally childbirth surveys perspective

ABSTRACT: This study recorded the physicochemical properties of the marula fruits, the biometry and breaking the dormancy in the marula seeds. Using 200 ripe fruits, the physicochemical characterization was done. From a random sample of 400 seeds, an assessment of the biometrics was performed, and the weight, length, width and thickness of the fruits and seeds were evaluated. Two experiments were conducted to study dormancy breaking using pre-germination treatments, which included immersing the marula seeds five times (0, 15, 30, 45 and 60 minutes) in concentrated sulfuric acid (96%) and water, at 65 ºC temperature. The control was time zero, using plain distilled water, with 25 seeds per treatment and four replications. The marula fruits revealed average values of 21.65 ± 3.44 g, 35.5 ± 2.38 and 34.8 ± 2.73, respectively, for weight, diameter and length. The soluble solids (SS), Hydrogenonic Potential (pH), titratable acidity (AT) and ratio (AT/SS) were 14.74 ± 1.0º Brix, 3.93 ± 0.49 pH, 0.63 ± 0.22 and 27.07 ± 12.10, respectively. For the weight of one thousand seeds, the average value was 3.576 ± 188.4 g. The mean values for the dimensions of the width, length and diameter of the seeds were 22.9 ± 2.11; 23.7 ± 2.04; and 14.9 ± 2.09 mm, respectively. The physiological quality of these seeds was enhanced by immersing the seeds from freshly picked fruits in sulfuric acid for a maximum of 30 minutes and storing them for six months. ABSTRACT 20 done 40 performed evaluated pregermination pre germination treatments 0, 0 (0 15 4 6 96% 96 (96% water temperature zero 2 replications 2165 21 21.6 344 3 44 3.4 g 355 35 5 35. 238 38 2.3 348 34 8 34. 273 73 2.73 respectively SS, SS , (SS) pH (pH) AT (AT AT/SS ATSS (AT/SS 1474 14 74 14.7 10º º 1 0º Brix 393 93 3.9 049 49 0.4 063 63 0.6 022 22 0.2 2707 27 07 27.0 1210 12 10 12.10 3576 576 3.57 1884 188 188. 229 9 22. 2.11 211 11 237 23 7 23. 2.04 204 04 149 14. 209 09 2.0 mm months ( (96 216 21. 3. 2. 2.7 (SS (pH 147 39 0. 06 02 270 27. 121 12.1 357 57 3.5 18 2.1 (9 12.

RESUMO: Objetivou-se com este trabalho estudar as características físico-químicas de frutos, biometria e superação da dormência de sementes de marula. Para a caracterização físico-química foram utilizados 200 frutos maduros. Realizou-se a biometria utilizando uma amostra aleatória de 400 sementes e foram avaliados: peso, comprimento, largura e espessura de frutos e sementes. Para o estudo da superação de dormência foram realizados dois experimentos com os tratamentos pré-germinativos constituídos pela imersão das sementes em ácido sulfúrico concentrado (96%) e água a temperatura de 65 ºC por cinco tempos (0, 15, 30, 45 e 60 minutos), sendo o tempo zero a testemunha, onde utilizou-se apenas água destilada, com quatro repetições de 25 sementes por tratamento. Os frutos de marula apresentaram valores médios de 21,65 ± 3,44 g, 35,5±2,38 e 34,8±2,73 mm de peso, diâmetro e comprimento, respectivamente e sólidos solúveis (SS), Potencial Hidrogeniônico ( pH), acidez titulável (AT) e ratio (AT/SS) foram de 14,74 ± 1,0 ºBrix, 3,93 ± 0,49 pH, 0,63 ± 0,22 e 27,07 ± 12,10 respectivamente. As sementes apresentaram valores médios de 3.576 ± 188,4 g para o peso de mil sementes. Para as dimensões, largura, comprimento e diâmetro de sementes, apresentaram valores médios de 22,9 ± 2,11; 23,7 ± 2,04; e 14,9 ± 2,09 mm respectivamente. A imersão das sementes procedentes de frutos recém colhidos em ácido sulfúrico por até 30 minutos e o armazenamento por seismeses promove incrementos na sua qualidade fisiológica. RESUMO Objetivouse Objetivou se físicoquímicas físico químicas físicoquímica química 20 maduros Realizouse Realizou 40 avaliados prégerminativos pré germinativos 96% 96 (96% 6 0, 0 (0 15 4 minutos, , minutos) testemunha utilizouse utilizou destilada 2 tratamento 2165 21 21,6 344 3 44 3,4 355238 35 5 38 35,5±2,3 348273 34 8 73 34,8±2,7 SS, SS (SS) pH pH) AT (AT AT/SS ATSS (AT/SS 1474 14 74 14,7 10 1 1, ºBrix 393 93 3,9 049 49 0,4 063 63 0,6 022 22 0,2 2707 27 07 27,0 1210 12 12,1 3576 576 3.57 1884 188 188, dimensões 229 9 22, 2,11 211 11 237 23 7 23, 2,04 204 04 149 14, 209 09 2,0 fisiológica (96 216 21, 3, 35523 35,5±2, 34827 34,8±2, (SS 147 39 06 02 270 27, 121 12, 357 57 3.5 18 2,1 2, (9 3552 35,5±2 3482 34,8±2 3. 355 35,5± 348 34,8± 35,5 34,8 35, 34,

ABSTRACT FGF21 is a hormone produced primarily by the liver with several metabolic functions, such as induction of heat production, control of glucose homeostasis, and regulation of blood lipid levels. Due to these actions, several laboratories have developed FGF21 analogs to treat patients with metabolic disorders such as obesity and diabetes. Here, we performed a systematic review and meta-analysis of randomized controlled trials that used FGF21 analogs and analyzed metabolic outcomes. Our search yielded 236 articles, and we included eight randomized clinical trials in the meta-analysis. The use of FGF21 analogs exhibited no effect on fasting blood glucose, glycated hemoglobin, HOMA index, blood free fatty acids or systolic blood pressure. However, the treatment significantly reduced fasting insulinemia, body weight and total cholesterolemia. None of the included studies were at high risk of bias. The quality of the evidence ranged from moderate to very low, especially due to imprecision and indirection issues. These results indicate that FGF21 analogs can potentially treat metabolic syndrome. However, more clinical trials are needed to increase the quality of evidence and confirm the effects seen thus far. FGF FGF2 functions production homeostasis levels actions diabetes Here metaanalysis meta analysis outcomes 23 articles metaanalysis. analysis. hemoglobin index pressure However insulinemia cholesterolemia bias low issues syndrome far 2

Abstract Frugivore bats are important seed dispersers in forests and their abundance are associated with the presence of zoochoric plants. In this context, the aim of our study was to investigate the association of the frugivore bat S. lilium with the diaspores of the zoochoric plant S. mauritianum, a common arboreal species present in forest fragments of southern Brazil. We also investigated the diet of the species based on seed content present in feces of individuals. Bats were mist-netted from November 2017 to April 2018 in a fragment of Atlantic Forest. The proportion of immature and mature diaspores of S. mauritianum was estimated in the same area where bats were sampled, and feces were sampled from captured individuals. In total, 61 individuals of S. lilium were captured, and 795 seeds were sampled from their feces. The abundance of S. lilium was significantly associated with the proportion of immature diaspores of S. mauritianum. We identified seeds of two botanical families: Solanaceae (89%) and Moraceae (11%) in the fecal samples. Our findings support the view that S. lilium is a legitimate disperser of S. mauritianum, and that its ecological function is probably a result of co-adaptation. plants context S Brazil mistnetted mist netted 201 Forest total 6 79 families 89% 89 (89% 11% 11 (11% samples coadaptation. coadaptation co adaptation. adaptation co-adaptation 20 7 8 (89 1 (11 2 (8 (1 (

Resumo No contexto de crise socioambiental que se evidencia na Amazônia Legal, este artigo tem como objetivo geral identificar vínculos entre as ações do governo brasileiro vigente (2019-2022) e a necropolítica socioambiental. Dentre os objetivos específicos, a investigação proposta visa a demonstrar a participação do governo federal em vigor no aumento dos incêndios, desmatamentos, invasões a territórios indígenas, garimpo ilegal e violência na Amazônia Legal. Com base na obra de Achille Mbembe, este estudo busca delimitar uma crise humanitária originada na necropolítica do governo Bolsonaro. Fazendo uso de uma metodologia quantitativa, esta pesquisa partiu da coleta de dados relacionados à desarticulação de normas ambientais garantidoras de políticas públicas, discursos oficiais de incitação à violação de normas ambientais e inércia no combate a crimes ambientais na Amazônia e contra os povos indígenas no período de janeiro de 2019 a agosto de 2022. Em uma análise qualitativa, tais dados foram inseridos em um quadro analítico derivado da obra de Mbembe sobre a necropolítica. Como resultado, restam reforçadas e justificadas as denúncias de crime contra a humanidade que tramitam contra o Presidente da República perante o Tribunal Penal Internacional (TPI). Legal 20192022 2022 (2019-2022 específicos incêndios desmatamentos Bolsonaro quantitativa públicas 201 qualitativa resultado TPI. TPI . (TPI) 2019202 202 (2019-202 20 (TPI 201920 (2019-20 2 20192 (2019-2 (2019- (2019 (201 (20 (2 (

Abstract Within the context of the socio-environmental crisis evident in the Legal Amazon region, this article aims to identify links between the actions of the current Brazilian government (2019-2022) and socio- -environmental necropolitics. Among the specific objectives, the proposed investigation seeks to demonstrate the involvement of the current federal government in the increase of fires, deforestation, invasions of Indigenous territories, illegal mining, and violence in the Legal Amazon region. Drawing from Achille Mbembe’s thesis, the study aims to delineate a humanitarian crisis stemming from the necropolitics of the Bolsonaro government. Employing a quantitative methodology, the research involved collecting data related to the dismantling of environmental norms that guarantee public policies, official discourses inciting the violation of environmental norms, inertia in combating environmental crimes in the Amazon and against Indigenous peoples, spanning from January 2019 to August 2022. In a qualitative analysis, these data were integrated into the analytical framework derived by the authors from Mbembe’s work on necropolitics. As a result, the accusations of crimes against humanity filed against the Brazilian president the International Criminal Court (ICC) are further reinforced and justified. socioenvironmental socio region 20192022 2022 (2019-2022 objectives fires deforestation territories mining Mbembes Mbembe s thesis methodology policies peoples 201 analysis result ICC (ICC justified 2019202 202 (2019-202 20 201920 (2019-20 2 20192 (2019-2 (2019- (2019 (201 (20 (2 (

Resumen En el contexto de la crisis socioambiental en la Amazonia Legal, este artículo tiene como objetivo identificar los vínculos entre las acciones del actual gobierno brasileño (2019-2022) y la necropolítica socioambiental. Entre los objetivos específicos, la investigación propuesta pretende demostrar la participación del actual gobierno federal en el aumento de los incendios, la deforestación, las invasiones de territorios indígenas, la minería ilegal y la violencia en la Amazonia Legal. A partir del trabajo de Achille Mbembe, este estudio busca delimitar una crisis humanitaria originada en la necropolítica del gobierno Bolsonaro. Utilizando una metodología cuantitativa, esta investigación comenzó con la recolección de datos relacionados con la desarticulación de las normas ambientales que garantizan las políticas públicas, los discursos oficiales que incitan a la violación de las normas ambientales y la inercia en la lucha contra los delitos ambientales en la Amazonía y contra los pueblos indígenas desde enero de 2019 hasta agosto de 2022. En un análisis cualitativo, tales datos se insertaron en un marco analítico derivado de la obra de Mbembe sobre la necropolítica. Como resultado, se refuerzan y justifican las acusaciones de crímenes contra la humanidad contra el Presidente de la República ante el Tribunal Penal Internacional (TPI). Legal 20192022 2022 (2019-2022 específicos incendios deforestación Bolsonaro cuantitativa públicas 201 cualitativo resultado TPI. TPI . (TPI) 2019202 202 (2019-202 20 (TPI 201920 (2019-20 2 20192 (2019-2 (2019- (2019 (201 (20 (2 (

Aim This study aimed to investigate the occurrence of enamelin gene (ENAM) single nucleotide polymorphisms (SNP) and ENAM polymorphism association with dental anomalies (DA) in individuals with unilateral or bilateral cleft lip and palate (CLP). Methods Saliva samples were collected from 147 individuals aged between 6 and 15 years-old, both genders, and divided into 4 groups: Group 1 (G1) - CLP and DA; Group 2 (G2) - CLP without DA; Group 3 (G3) - without CLP with DA; Group 4 (G4) - without CLP and DA. The genomic DNA was extracted from saliva samples and the following ENAM SNPs markers were genotyped: rs3796703, rs3796704, rs3796705, rs7671281, rs2609428, and rs35951442. Fisher exact and Pearson’s Chi-square tests statistically analyzed the results (α=5%). Results Individuals without CLP with DA (Group 3 - 19.2%) showed statistically higher prevalence of SNP rs2609428 heterozygotes (p=0.006) than individuals with CLP and DA (Group 1 - 0%). Individuals without CLP (10%) exhibited statistically higher prevalence of mutated heterozygotes/homozygous (p=0.028) than in individuals with CLP (1.3%). Conclusion SNP rs2609428 marker of ENAM gene may be associated with dental anomalies in individuals without cleft lip and palate. (ENAM (SNP (DA CLP. . (CLP) 14 yearsold, yearsold years old, old years-old genders groups G1 G (G1 G2 (G2 G3 (G3 G4 (G4 genotyped rs3796703 rs rs3796704 rs3796705 rs7671281 rs35951442 Pearsons Pearson s Chisquare Chi square α=5%. α5 α α=5% 5 (α=5%) 19.2% 192 19 rs260942 p=0.006 p0006 p 0 006 (p=0.006 0%. 0% 0%) 10% 10 (10% heterozygoteshomozygous homozygous p=0.028 p0028 028 (p=0.028 1.3%. 13 1.3% (1.3%) (CLP (G rs379670 rs767128 rs3595144 α=5 (α=5% 19.2 rs26094 p=0.00 p000 00 (p=0.00 (10 p=0.02 p002 02 (p=0.02 1.3 (1.3% rs37967 rs76712 rs359514 α= (α=5 19. rs2609 p=0.0 p00 (p=0.0 (1 1. (1.3 rs3796 rs7671 rs35951 (α= rs260 p=0. p0 (p=0. ( (1. rs379 rs767 rs3595 (α rs26 p=0 (p=0 rs37 rs76 rs359 rs2 p= (p= rs3 rs7 rs35 (p

Abstract The present study investigates the intersecting impacts of race/color, education and place of residence on the non-adequacy of care provided in different dimensions of prenatal care. To this end, we analyzed data from the 2013 National Health Survey using multiple logistic regression models. The results suggest that the variables operate together to shape non-adequacy to prenatal care. Black women and those with less schooling were more likely to miss 6 prenatal consultations, starting before the 12th week of pregnancy. Women up to 20 years of age, those residing in the North, Northeast and Midwest regions and those with less schooling were less submitted to the recommended laboratory and physical exams. And, finally, black women and those up to 20 years of age were more likely to not receive guidance on childbirth. Our findings reiterate the multifaceted nature of the problem and point to the insufficiency of population surveys, by not including and not allowing the characterization of the most marginalized segments of the population, making it difficult to further investigate realities from an intersectional perspective. racecolor race color race/color nonadequacy non adequacy end 201 models consultations th pregnancy 2 North exams And finally childbirth surveys perspective

Resumo O estudo investiga o impacto do intercruzamento de raça/cor, escolaridade e local de residência na não adequação do cuidado prestado em diferentes dimensões do pré-natal. Para tal, analisaram-se dados da Pesquisa Nacional de Saúde de 2013 com modelos de regressão logística múltipla. Os resultados sugerem que as variáveis operam em conjunto na não adequação ao pré-natal. As mulheres negras e as menos escolarizadas apresentaram maior probabilidade de não ter 6 consultas de pré-natal, iniciadas antes da 12ª semana de gestação. Mulheres de até 20 anos de idade, residentes nas regiões Norte, Nordeste e Centro-Oeste e menos escolarizadas foram menos submetidas aos exames laboratoriais e físicos preconizados. E, por último, mulheres negras e de até 20 anos de idade foram mais propensas a não receber orientações sobre o parto. Os achados reiteram a natureza multifacetada do problema e alertam para a insuficiência dos inquéritos populacionais, ao não incluir e não permitir a caracterização dos segmentos mais marginalizados da população, dificultando a investigação de realidades segundo uma perspectiva interseccional. raçacor raça cor raça/cor prénatal. prénatal pré natal. natal pré-natal tal analisaramse analisaram se 201 múltipla prénatal, natal, ª gestação 2 Norte CentroOeste Centro Oeste preconizados E último parto populacionais população interseccional

Abstract Finding ways to reuse residue is an alternative not only to reduce its presence in urban and natural environments, but also to reduce costs and consumption of resources by industries. The objective of this paper is to evaluate the properties of concretes made by replacing conventional coarse and fine aggregates with marble residue. Morphological, granulometry, specific gravimetry and crystalline phase analyses were carried out in the aggregates. The composition of the constituents, by mass, was 1:1,2:3 of Portland cement CPIII-32 RS, fine aggregates, and coarse aggregate, respectively, with the addition of 0.4 of water, molded and cured in water. About 25 concrete samples were made, varying the amount of coarse/fine aggregate in the cement mass according to the aggregates proportions of: A= 100% gravel/ 100% sand, B= 100% coarse RRO/ 50% fine RRO + 50% sand, C= 50% coarse RRO + 50% gravel/ 100% fine RRO, and D = 100% coarse RRO/100% fine RRO. The cylindrical samples measuring ∅50 x 100 mm were subjected to water absorption and compressive strength tests, and the results were compared with standards and literature. The water absorption was smaller than 2.5% and the compressive strength values were between 27-33 MPa, close to the resistance of cement used. Composition B presented the best results among the others, indicating the possibility of using the residue from marble for production of concretes for various purposes such as low load paving, sidewalks, blocks, among others. However, for interlocking floors, higher performance cement should be used to achieve the required strength. This type of concrete adds value to the residue and mitigates environmental impacts. environments industries Morphological granulometry constituents 11,23 1123 1 1,2 3 2 1:1,2: CPIII32 CPIII 32 CPIII-3 RS respectively 04 0 4 0. coarsefine A gravel sand 50 C RRO100 RRO/100 ∅5 10 tests literature 5 2.5 2733 27 33 27-3 MPa others paving sidewalks blocks However floors impacts 11 23 11,2 112 12 1, 1:1,2 CPIII3 CPIII- RRO10 RRO/10 ∅ 2. 273 27- 11, 1:1, RRO1 RRO/1 1:1 1:

Resumo Encontrar formas de reaproveitar resíduos é uma alternativa não só para reduzir sua presença em ambientes urbanos e naturais, mas também para reduzir custos e consumo de matérias primas pelas indústrias. O objetivo deste trabalho é avaliar as propriedades de concretos fabricados através da substituição de agregados graúdos e miúdos convencionais por resíduo de mármore. Foram realizadas análises de morfologia, granulometria, massa específica e da fase cristalina dos agregados. A composição dos constituintes, em massa, foi 1:1,2:3 de cimento Portland CPIII-32 RS, agregados miúdos e agregados graúdos, respectivamente, com adição de 0,4 de água, moldados e curados em água. Foram confeccionadas cerca de 25 amostras de concreto, variando a quantidade de agregado graúdo/fino na massa de cimento de acordo com as proporções de agregados de: A= 100% brita/ 100% areia, B= 100% RRO grosso/ 50% RRO fino + 50% areia, C= 50% RRO grosso + 50% cascalho/ 100% RRO fino, e D = 100% RRO grosso/100% RRO fino. As amostras cilíndricas medindo ∅50 x 100 mm foram submetidas a testes de absorção de água e resistência à compressão, e os resultados obtidos foram comparados com algumas normas e com a literatura. A absorção de água foi inferior a 2,5% e a resistência à compressão ficou entre 27-33 MPa, valor próximo à resistência do cimento utilizado. A composição B apresenta os melhores resultados entre as demais, indicando a possibilidade de utilização do resíduo do mármore para produção de concretos para diversas finalidades como pavimentação de baixa carga, calçadas, blocos, entre outros. No entanto, para pisos intertravados, deve-se utilizar cimento de maior desempenho para atingir a resistência necessária. Esse tipo de concreto agrega valor ao resíduo e mitiga os impactos ambientais. naturais indústrias morfologia granulometria constituintes 11,23 1123 1 1,2 3 2 1:1,2: CPIII32 CPIII 32 CPIII-3 RS respectivamente 04 0 4 0, graúdofino graúdo brita areia 50 C cascalho grosso100 grosso/100 ∅5 10 literatura 5 2,5 2733 27 33 27-3 MPa utilizado demais carga calçadas blocos outros entanto intertravados devese deve se necessária ambientais 11 23 11,2 112 12 1, 1:1,2 CPIII3 CPIII- grosso10 grosso/10 ∅ 2, 273 27- 11, 1:1, grosso1 grosso/1 1:1 1:

Abstract Background: Loxoscelism refers to a set of clinical manifestations caused by the bite of spiders from the Loxosceles genus. The classic clinical symptoms are characterized by an intense inflammatory reaction at the bite site followed by local necrosis and can be classified as cutaneous loxoscelism. This cutaneous form presents difficult healing, and the proposed treatments are not specific or effective. This study aimed to evaluate the protective effect of mesenchymal stromal cells-derived secretome on dermonecrosis induced by Loxosceles intermedia spider venom in rabbits. Methods: Sixteen rabbits were distributed into four groups (n = 4). Except for group 1 (G1), which received only PBS, the other three groups (G2, G3, and G4) were initially challenged with 10 μg of L. intermedia venom, diluted in 100 μL of NaCl 0.9%, by intradermic injection in the interscapular region. Thirty minutes after the challenge all groups were treated with secretome, except for group 2. Group 1 (G1-control group) received intradermal injection (ID) of 60 μg of secretome in 0.15 M PBS; Group 2 (G2) received 0.9% NaCl via ID; Group 3 (G3) received 60 μg of secretome, via ID and Group 4 (G4), received 60 μg of secretome by intravenous route. Rabbits were evaluated daily and after 15 days were euthanized, necropsied and skin samples around the necrotic lesions were collected for histological analysis. Results: Rabbits of G1 did not present edema, erythema, hemorrhagic halo, or necrosis. In animals from G2, G3, and G4, edema appeared after 6h. However, minor edema was observed in the animals of G2 and G3. Hemorrhagic halo was observed in animals, six hours and three days after, on G2, G3, and G4. Macroscopically, in G4, only one animal out of four had a lesion that evolved into a dermonecrotic wound. No changes were observed in the skin of the animals of G1, by microscopic evaluation. All animals challenged with L. intermedia venom showed similar alterations, such as necrosis and heterophilic infiltration. However, animals from G4 showed fibroblast activation, early development of connective tissue, neovascularization, and tissue re-epithelialization, indicating a more prominent healing process. Conclusion: These results suggest that secretome from mesenchymal stromal cells cultured in a xeno-free and human component-free culture media can be promising to treat dermonecrosis caused after Loxosceles spiders bite envenoming. Background genus loxoscelism effective cellsderived derived Methods n 4. . 4) G , (G1) PBS (G2 G3 L 09 0 9 region G1control Gcontrol control (ID 6 015 0.1 0.9 (G3 (G4) route euthanized analysis Results erythema 6h h However Macroscopically wound evaluation alterations infiltration activation neovascularization reepithelialization, reepithelialization re epithelialization, epithelialization re-epithelialization process Conclusion xenofree xeno free componentfree component envenoming (G1 (G 01 0. (G4

Abstract: The socio-environmental impacts caused by the collapse of a mining dam can be irreversible. In Brazil, the dam collapse at the Córrego do Feijão Mine was considered one of the worst disasters in the country. Remote sensing-based approaches have been used to detect and monitor areas affected by tailings from dam rupture. Therefore, it was proposed to identify the area affected by mining tailing mud, in Brumadinho, Minas Gerais State, through the analysis of three different spectral indices: Normalized Difference Vegetation Index (NDVI), Ferrous Minerals Ratio (FMR) and Clay Minerals Ratio (CMR). These indices were computed from the Operational Land Imager (OLI) images of Landsat-8. Different thresholds were tested to define the best range for delineating the affected area. For validation, the limits of the affected area, obtained from a higher resolution sensor, GeoEye-1, were used as reference. The methodology demonstrated great potential for detecting areas affected by dam failure. The indices NDVI and FMR delimited the area of interest with high performance, with precision varying between 95% and 92%; recall between 88% and 87%; F-score between 91% and 89%; and global accuracy between 84% and 80%, showing to be suitable mapping such disasters. Abstract socioenvironmental socio environmental irreversible Brazil country sensingbased sensing based rupture Therefore mud Brumadinho State NDVI, , (NDVI) (FMR CMR. CMR . (CMR) OLI (OLI Landsat8. Landsat8 Landsat 8. 8 Landsat-8 validation sensor GeoEye1, GeoEye1 GeoEye 1, 1 GeoEye-1 reference failure performance 95 92% 92 88 87% 87 Fscore F score 91 89% 89 84 80 80% (NDVI (CMR Landsat- GeoEye- 9

Resumo O estudo investiga o impacto do intercruzamento de raça/cor, escolaridade e local de residência na não adequação do cuidado prestado em diferentes dimensões do pré-natal. Para tal, analisaram-se dados da Pesquisa Nacional de Saúde de 2013 com modelos de regressão logística múltipla. Os resultados sugerem que as variáveis operam em conjunto na não adequação ao pré-natal. As mulheres negras e as menos escolarizadas apresentaram maior probabilidade de não ter 6 consultas de pré-natal, iniciadas antes da 12ª semana de gestação. Mulheres de até 20 anos de idade, residentes nas regiões Norte, Nordeste e Centro-Oeste e menos escolarizadas foram menos submetidas aos exames laboratoriais e físicos preconizados. E, por último, mulheres negras e de até 20 anos de idade foram mais propensas a não receber orientações sobre o parto. Os achados reiteram a natureza multifacetada do problema e alertam para a insuficiência dos inquéritos populacionais, ao não incluir e não permitir a caracterização dos segmentos mais marginalizados da população, dificultando a investigação de realidades segundo uma perspectiva interseccional.

Abstract The present study investigates the intersecting impacts of race/color, education and place of residence on the non-adequacy of care provided in different dimensions of prenatal care. To this end, we analyzed data from the 2013 National Health Survey using multiple logistic regression models. The results suggest that the variables operate together to shape non-adequacy to prenatal care. Black women and those with less schooling were more likely to miss 6 prenatal consultations, starting before the 12th week of pregnancy. Women up to 20 years of age, those residing in the North, Northeast and Midwest regions and those with less schooling were less submitted to the recommended laboratory and physical exams. And, finally, black women and those up to 20 years of age were more likely to not receive guidance on childbirth. Our findings reiterate the multifaceted nature of the problem and point to the insufficiency of population surveys, by not including and not allowing the characterization of the most marginalized segments of the population, making it difficult to further investigate realities from an intersectional perspective.

Abstract The objective of this study was to evaluate the nutritional functionality of the xylanolytic complex produced from Aspergillus japonicus var. aculeatus UFMS 48.136 isolated from the Cerrado/ Pantanal biome in Mato Grosso do Sul, compared to commercial xylanase, in swine diets. Sixteen barrows were used, with an initial weight of 64.23 ± 10.5 kg, distributed in a randomized block experimental design, with four diets: control, formulated according to nutritional recommendations; negative control, formulated with a reduction of 100 Kcal / kg of metabolizable energy (ME); negative control + xylanase Cerrado / Pantanal; negative control + commercial xylanase; with four repetitions each. The xylanase supplementation provided higher (P<0.05) values of digestible energy (DE), ME, and higher (P<0.05) digestibility of dry matter (DM), organic matter (OM), crude protein (CP), ether extract (EE), neutral detergent fiber (NDF), and acid detergent fiber (ADF) in relation to the negative control diet, but without differing (P>0.05) from the control diet. The inclusion of xylanases increased (P<0.05) in the coefficients of digestibility (CD) and metabolism of crude energy (CE), DM, OM, CP, EE, NDF, and ADF. There was no difference (P>0.05) in digestibility and CD values between Cerrado/Pantanal and commercial xylanase. The inclusion of xylanases made it possible to reduce 100 Kcal of ME per kilogram of diet. Cerrado/Pantanal xylanases therefore have the same nutritional efficiency as commercial xylanases. var 48136 48 136 48.13 Sul diets used 6423 64 23 64.2 105 10 5 10. design recommendations (ME) each P<0.05 P005 P 0 05 (P<0.05 DE, DE , (DE) DM (DM) OM (OM) CP (CP) EE (EE) NDF (NDF) ADF (ADF diet P>0.05 (P>0.05 (CD CE, CE (CE) CerradoPantanal 4813 4 13 48.1 642 6 2 64. 1 (ME P<0.0 P00 (P<0.0 (DE (DM (OM (CP (EE (NDF P>0.0 (P>0.0 (CE 481 48. P<0. P0 (P<0. P>0. (P>0. P<0 (P<0 P>0 (P>0 P< (P< P> (P> (P

Resumo Realizou-se este estudo com o objetivo de avaliar a funcionalidade nutricional do complexo xilanolítico produzido a partir de fungos da linhagem Aspergillus japonicus var. aculeatus UFMS 48.136, oriundo do bioma Cerrado/Pantanal sul mato-grossense em comparação à xilanase comercial, em dietas de suínos. Foram utilizados dezesseis suínos machos, com peso inicial de 64,23 ± 10,5 kg, distribuídos em delineamento experimental de blocos ao acaso, com quatro dietas: controle, formulado de acordo com as recomendações nutricionais; controle negativo, formulado com redução de 100 Kcal / kg de energia metabolizável (EM); controle negativo + xilanase Cerrado / Pantanal; controle negativo + xilanase comercial; com quatro repetições cada. A suplementação das xilanases proporcionou maiores (P<0,05) valores de energia digestível (ED), metabolizável (EM) e maiores (P<0,05) digestibilidade da matéria seca (MS), matéria orgânica (MO), proteína bruta (PB), extrato etéreo (EE), fibra em detergente neutro (FDN) e fibra em detergente ácido (FDA) em relação à dieta controle negativo, mas sem diferir (P>0,05) da dieta controle. A inclusão das xilanases proporcionou aumento (P<0,05) nos coeficientes de digestibilidade (CD) e metabolizabilidade da energia bruta (EB), MS, MO, PB, EE, FDN e FDA. Não foi constatada diferença (P>0,05) nos valores de digestibilidade e de CD entre as xilanase Cerrado/Pantanal e Comercial. A inclusão das xilanases possibilita a redução de 100 Kcal de EM por kg da dieta. A xilanase Cerrado / Pantanal possui a mesma eficiência nutricional em comparação com a xilanase comercial. Realizouse Realizou se var 48136 48 136 48.136 CerradoPantanal matogrossense mato grossense comercial machos 6423 64 23 64,2 105 10 5 10, acaso nutricionais cada P<0,05 P005 P 0 05 (P<0,05 ED, ED , (ED) (EM MS (MS) MO (MO) PB (PB) EE (EE) (FDN FDA (FDA P>0,05 (P>0,05 (CD EB, EB (EB) Comercial 4813 4 13 48.13 642 6 2 64, 1 P<0,0 P00 (P<0,0 (ED (MS (MO (PB (EE P>0,0 (P>0,0 (EB 481 48.1 P<0, P0 (P<0, P>0, (P>0, 48. P<0 (P<0 P>0 (P>0 P< (P< P> (P> (P

Abstract Sedentary behavior, intestinal constipation, and eating habits were examined concerning sociodemographic factors. A cross-sectional and analytical study was conducted with adolescents from municipal public schools in Montes Claros-MG, Brazil, through questionnaires investigating sociodemographic factors, pediatric gastrointestinal symptoms (Questionnaire Roma III), and eating habits (VIGITEL). Data were treated in the Statistical Package for Social Science program (version 22.0) through descriptive analysis of variables and the chi-square test. Of the 880 participants, the majority were female (51.93%) and aged between 13 and 19 (60.11%). A percentage of 16.7% exceeded 5 hours of sedentary behavior per day, and 15% were constipated. When comparing Sedentary Behavior with the sociodemographic profile, adolescent boys were more sedentary (p = .02), as were older adolescents (p = .01). In conclusion, there was a low prevalence of Sedentary Behavior, and the associations referred to sociodemographic factors. However, considering the studied population and the damage caused by sedentary behavior to the health of adolescents, these results are important to help in tracking this disorder.

Resumo Esse estudo teve por objetivo estimar a prevalência do Comportamento Sedentário e sua associação com fatores sociodemográficos, Constipação Intestinal e hábitos alimentares. Para tal, foi realizado um estudo transversal e analítico, desenvolvido com adolescentes do 6° ao 9° anos das escolas públicas municipais da cidade de Montes Claros-MG, Brasil. Foram utilizados questionários que abordavam fatores sociodemográficos, sintomas gastrointestinais pediátricos (Questionário Roma III) e hábitos alimentares (VIGITEL). Os dados foram tratados no programa Statistical Package for the Social Science versão 22.0 por meio de análise descritiva das variáveis e do teste qui-quadrado. Participaram 880 adolescentes. 16.7% ultrapassavam 5 horas diárias com adoção do Comportamento Sedentário, sendo a maior prevalência encontrada no sexo feminino (51.93%), e faixa etária de 13 a 19 anos (60.11%). 15% dos entrevistados eram constipados. Ao comparar o Comportamento Sedentário com o perfil sociodemográfico, percebe-se que os meninos adolescentes eram mais sedentários (p = .02) e aos adolescentes com maior idade (p = .01). Concluindo, verificou-se baixa prevalência de Comportamento Sedentário, e as associações referiram a fatores sociodemográficos. No entanto, considerando a população estudada e os prejuízos advindos do Comportamento Sedentário para a saúde dos adolescentes, esses resultados são importantes para auxiliar no rastreamento desse distúrbio.

Abstract Objective To evaluate the efficacy and safety of romiplostim (thrombopoietin-receptor agonist) in the treatment of pediatric immune thrombocytopenia (ITP). Methods Searches were conducted in MEDLINE, EMBASE, LILACS, Cochrane Central Register of Controlled Trials and ClinicalTrials.gov (from January 2011 to August 2021). Randomized controlled trials (RCTs), double-blind, comparing romiplostim with a placebo in pediatric persistent or chronic ITP were included. The primary outcome was the overall response rate (platelets ≥ 50 × 109/L) in the absence of rescue therapy for at least two consecutive weeks. The secondary endpoints were the minimization of clinically significant bleeding and the necessity for rescue treatments and the maximization of safety (incidence of overall adverse events) and durable response (maintaining platelet counts for at least twelve weeks). Results Two double-blind randomized placebo-controlled trials (84 participants) were included in this systematic review. Our data showed that, compared to the placebo group, the proportion of patients achieving durable platelet response was significantly higher in the romiplostim group (p= 0.003, RR = 6.34, 95%CI = 1.89 - 21.23), as was the overall response in the romiplostim group (p= 0.002, RR = 3.62, 95%CI = 1.63 - 8.03). Significant bleeding incidents (p= 0.49), overall adverse events (p= 0.71) and the need for rescue treatment (p= 0.13) were not statistically different between the romiplostim and placebo groups. Conclusions Romiplostim might improve both durable and overall platelet response in children and adolescents with ITP, compared to a placebo. More clinical trials are needed to evaluate the efficacy and safety of romiplostim and to compare it with other second-line treatments that are being used in pediatric ITP. thrombopoietinreceptor thrombopoietin receptor agonist . (ITP) MEDLINE EMBASE LILACS ClinicalTrialsgov ClinicalTrials gov from 201 2021. 2021 2021) RCTs, RCTs , (RCTs) doubleblind, doubleblind double blind, blind platelets 5 109/L 109L L 109 weeks incidence maintaining weeks) placebocontrolled 84 (8 participants review p= p (p 0003 0 003 0.003 634 6 34 6.34 95CI CI 95 189 1 89 1.8 21.23, 2123 21.23 21 23 21.23) 0002 002 0.002 362 3 62 3.62 163 63 1.6 8.03. 803 8.03 8 03 8.03) 0.49, 049 0.49 49 0.49) 0.71 071 71 0.13 013 13 groups secondline second line (ITP 20 202 (RCTs 10 ( 000 00 0.00 6.3 9 18 1. 212 21.2 2 36 3.6 16 80 8.0 04 0.4 4 0.7 07 7 0.1 01 0.0 6. 21. 3. 8. 0.