Resumo Os microRNAs (miRNAs) são reconhecidos como biomarcadores do diabetes mellitus tipo 2 (DM2), úteis para a compreensão do metabolismo da doença, e possuem grande potencial como alvos terapêuticos. O aumento da expressão de BDNF e IGF1 está altamente envolvido nos benefícios as vias de insulina e glicose, porém, são regulados negativamente em condições de resistência à insulina, enquanto seu aumento de expressão está correlacionado com a melhora do metabolismo da glicose e da insulina. Estudos sugerem a regulação desses genes por microRNA em vários contextos diferentes, proporcionando uma nova abordagem de investigação para compreender o metabolismo do DM2 e revelar potenciais alvos terapêuticos. No presente estudo, investigamos em diferentes modelos animais (humanos, ratos e camundongos) miRNAs que têm como alvo BDNF e IGF1 em tecido muscular esquelético com condições fisiológicas de DM2. As análises foram realizadas utilizando ferramentas de bioinformática e bancos de dados para predição de miRNA, homologia molecular, validação experimental de interações, expressão na condição fisiológica estudada e interação em rede. Os resultados mostraram três candidatos a miRNAs para IGF1 (miR-29a, miR-29b e miR-29c) e um para BDNF (miR-206). As avaliações experimentais e a busca pela expressão no músculo esquelético de indivíduos com DM2 confirmaram a interação prevista entre miRNA-mRNA para miR-29b e miR-206 através de modelos humanos, ratos e camundongos. Essa interação foi reafirmada em múltiplas análises de rede. Em conclusão, nossos resultados mostram a relação de regulação entre miR-29b e miR-206 com os genes investigados, em diversos tecidos, sugerindo um padrão de inibição. Contudo, esses dados mostram um grande número de possíveis processos fisiológicos de interação para perspectivas biotecnológicas.

Abstract microRNAs (miRNAs) are recognized as diabetes mellitus type 2 (T2DM) biomarkers useful for disease metabolism comprehension and have great potential as therapeutics targets. BDNF and IGF1 increased expression are highly involved in the benefits of insulin and glucose paths, however, they are down-regulated in insulin resistance conditions, while their expression increase is correlated to the improvement of glucose and insulin metabolism. Studies suggest the microRNA regulation of these genes in several different contexts, providing a novel investigation approach for comprehending T2DM metabolism and revealing potential therapeutic targets. In the present study, we investigate in different animal models (human, rat, and mouse) miRNAs that target BDNF and IGF1 in skeletal muscle tissue with T2DM physiological conditions. Bioinformatics tools and databases were used to miRNA prediction, molecular homology, experimental validation of interactions, expression in the studied physiological condition, and network interaction. The findings showed three miRNAs candidates for IGF1(miR-29a, miR-29b, and miR-29c) and one for BDNF (miR-206). The experimental evaluations and the search for the expression in skeletal muscle from T2DM subjects confirmed the predicted interaction between miRNA-mRNA for miR-29b and miR-206 through human, rat, and mouse models. This interaction was reaffirmed in multiple network analyses. In conclusion, our results show the regulation relationship between miR-29b and miR-206 with the investigated genes, in several tissues, suggesting an inhibition pattern. Nevertheless, these data show a large number of possible interaction physiological processes, for future biotechnological prospects.

Resumo Aspectos da biologia reprodutiva de Donax striatus foram estudados. Os indivíduos foram coletados mensalmente de fevereiro de 2021 a janeiro de 2022 na praia Gado Bravo, no município de Tibau do Norte, estado do Rio Grande do Norte, Brasil. Donax striatus é uma espécie dióica sem dimorfismo macroscópico externo (na concha) ou interno (gônadas). Assim, é necessário um exame microscópico das células reprodutivas. Para a caracterização dos estágios de desenvolvimento gonadal e determinação do tamanho na primeira maturidade sexual (L50), 30 espécimes foram selecionados mensalmente entre fevereiro de 2021 e janeiro de 2022 e submetidos ao processamento histológico. O índice de Condição (IC) de cada indivíduo foi estimado e as variações mensais foram estatisticamente avaliadas. O tamanho de primeira maturação (L50) foi estimado em 14,2 mm de comprimento de concha. Para promover a conservação da espécie, recomenda-se a captura de indivíduos maiores que 14,2 mm. Os menores índices de condição foram encontrados na estação seca, com maior ocorrência de organismos em fase de eliminação e exibindo reorganização do tecido gonadal. Índices maiores foram encontrados no período chuvoso, com presença de indivíduos maduros. A natureza contínua da gametogênese em Donax stritatus reflete a influência das chuvas na região. Machos e fêmeas apresentam pico de eliminação de gametas com pausas durante o ano, mas com presença de indivíduos em maturação e eliminação ao longo do ano. Como a mariscagem visando Donax striatus é excessiva na Praia de Gado Bravo, no estado do Rio Grande do Norte, espera-se que os resultados do presente estudo possam contribuir para o estabelecimento de medidas de manejo da atividade e estratégias de conservação da espécie. estudados 202 Bravo Norte Brasil concha gônadas. gônadas . (gônadas) Assim reprodutivas L50, L50 L , 3 histológico IC (IC avaliadas (L50 142 14 2 14, recomendase recomenda se seca chuvoso maduros região ano esperase espera 20 (gônadas L5 (L5 1 (L

Abstract Aspects of the reproductive biology of Donax striatus were studied from individuals collected from Gado Bravo Beach in the municipality of Tibau do Norte, state of Rio Grande do Norte, Brazil. Donax striatus is a dioic species without external (on the shell) or internal (gonads) macroscopic dimorphism. Thus, a microscopic examination of the reproductive cells is necessary. For the characterization of the gonadal development stages and determination of the size at first sexual maturity (L50), 30 specimens were selected monthly between February 2021 and January 2022 and submitted to histological processing. The condition index (CI) of each individual was estimated and monthly variations were statistically assessed. The size at first maturity (L50) was estimated to be 14.2 mm in shell length. To foster conservation of the species, catches of individuals larger than 14.2 mm is recommended. The lowest condition indices were found in the dry season, with a greater occurrence of organisms in the elimination stage and exhibiting gonad tissue reorganization. Higher indices were found in the rainy season, with the presence of mature individuals. The continuous nature of gametogenesis in Donax stritatus reflects the influence of rainfall in the region. Males and females have peak gamete elimination with pauses during the year, but with the presence of maturing and eliminating individuals throughout the year. As shellfish gathering targeting Donax striatus is excessive on Gado Bravo Beach in the state of Rio Grande do Norte, it is hoped that the results of the present study can contribute to the establishment of management measures for the activity and conservation strategies for the species. Norte Brazil gonads (gonads dimorphism Thus necessary L50, L50 L , 3 202 processing CI (CI assessed (L50 142 14 2 14. length recommended season reorganization region year L5 20 (L5 1 (L

The Grad-Shafranov (GS) equation is a fundamental tool extensively used in plasma physics, particularly in the context of magnetic confinement, notably in tokamaks for fusion energy research. This equation plays a crucial role in reconstructing magnetic field topology in plasma regions like the magnetopause and magnetotail, leading to the development of the GS reconstruction technique. In this third installment of our series, we explore the merger of the Yoon-Lui-2 and Yoon-Lui-3 generating functions, allowing for a deeper understanding of the core equation in Plasma Physics. Furthermore, this article provides a comprehensive summary of solutions previously presented in Parts 1 and 2. We investigate the behavior of magnetic islands positioned above either the X-axis or the Z-axis for specific parameter values and their impact on plasma confinement. The article concludes that the derived model offers a simpler, more stable, and easily analyzable solution for magnetic morphology. However, it is worth noting that the model’s inflexibility in singularity positions may limit its adaptability to different scenarios. This article marks the conclusion of our physics education series dedicated to studying new specific solutions of the GS equation. GradShafranov Grad Shafranov (GS confinement research magnetotail technique YoonLui2 YoonLui Yoon Lui 2 Yoon-Lui- YoonLui3 3 functions Physics Furthermore Xaxis X axis Zaxis Z simpler stable morphology However models s scenarios Yoon-Lui

Resumo A incorporação de materiais alternativos em substituição parcial ao clínquer é estudada afim de diminuir a emissão de CO2 que ocorre na produção do cimento Portland. Analisou-se a influência do uso da cinza de algaroba como fíler alternativo em pastas de cimento LC3. O teor de álcali do sistema foi ajustado lavando a cinza e, assim, reduzindo o teor de potássio. O fíler foi substituído em 0, 25%, 50%, 75% e 100% de cinza lavada e o mesmo para cinza não lavada. A subsulfatação foi corrigida adicionando-se uma porcentagem de gesso extra. O desempenho da pasta foi avaliado pela reologia e resistência à compressão, sustentada pela cinética de hidratação e desenvolvimento microestrutural. A cinza de algaroba é um potencial fíler alternativo para aplicação em LC3. A cinza lavada torna o sistema mais puro, contribuindo na hidratação e desempenho mecânico, entretanto, a cinza natural também traz resultados promissores. CO Portland Analisouse Analisou se LC3 LC assim potássio 0 25 25% 50 50% 75 100 adicionandose adicionando extra compressão microestrutural puro mecânico entretanto promissores 2 5 7 10 1

Abstract The incorporation of alternative materials in partial replacement of clinker is studied to reduce the CO2 emissions that occur in the production of Portland cement. The influence of using mesquite ash as an alternative filler in LC3 cement pastes was analyzed. The alkali content of the system was adjusted by washing the ash, thus reducing the potassium content. The filler was replaced at 0, 25%, 50%, 75%, and 100% washed ash, and the same for unwashed ash. Subsulfation was corrected by adding an extra gypsum percentage. Paste performance was assessed by rheology and compressive strength, supported by hydration kinetics and microstructural development. Mesquite ash is a potential alternative filler for application in LC3. Washed ash makes the system purer, contributing to hydration and mechanical performance, however, natural ash also brings promising results. CO LC analyzed 0 25 25% 50 50% 75 75% 100 percentage strength development purer however results 2 5 7 10 1

Abstract CuCrO2 was synthesized by solution combustion synthesis (SCS) and applied as a heterogeneous catalyst to produce soybean biodiesel. The combustion reaction was carried out using urea as a fuel, and copper (II) and chromium (III) nitrates as precursors. After the powders’ obtention, these were calcined and functionalized in an acidic medium. The powders were characterized by thermogravimetry (TG), X-ray diffraction (XRD), scanning electron microscopy (SEM), and infrared spectroscopy (IR) techniques. The TG curve revealed that the formation of the CuCrO2 in the combustion reaction remained stable up to 1000 °C. The XRD results confirmed the formation of the CuCrO2 compound. The SEM images showed that the crystallinity of the samples increased after the calcination process. The IR spectra showed the presence of delafossite characteristic bands. After the transesterification reaction, biodiesel was obtained with a yield of around 80%. Thus, catalysts based on delafossite synthesized through the combustion method and functionalized showed to be promising for the transesterification reaction of vegetable oils. CuCrO SCS (SCS fuel II (II III (III precursors obtention medium TG, , (TG) Xray X ray XRD, (XRD) SEM, (SEM) (IR techniques 100 C °C compound process bands 80 80% Thus oils (TG (XRD (SEM 10 8 1

The effect of heat treatment on hydrogen diffusion and trapping on the API 5CT P110 steel was investigated trough electrochemical permeation tests and microstructural analysis techniques. Samples of as-received steel were tempered at different temperatures to obtain hydrogen permeation and trapping parameters and to characterize microstructural modifications that may alter these parameters. After permeation tests on each heat-treatment condition were verified changes on hydrogen kinetic parameters. Microstructural analysis revelated changes in dislocations density and volumetric fraction of titanium carbides, responsible to alterations in diffusivity, solubility and in hydrogen trapping characteristics. As these carbides are considered irreversible hydrogen traps, are beneficial because they become the steels less susceptible to hydrogen embrittlement. Therefore, the results suggest that there is an optimal tempering temperature which can make the API 5CT P110 steel more resistant against hydrogen embrittlement, since promote the formation of a higher number of irreversible hydrogen traps. CT P P11 techniques asreceived as received heattreatment diffusivity characteristics traps embrittlement Therefore P1

In part 1 of our physics education series, we introduced a novel solution based on Yoon-Lui’s solutions 1 and 2. Building upon that, this follow-up presents a new solution obtained by combining the generating functions of Yoon-Lui-1 and Yoon-Lui-3, resulting in a new and simplified general solution. We also calculate the singular points and determine their coordinates for various parameter values. A graphical representation of the solution is presented, showing the magnetic field lines and current density distribution. The behavior of the magnetic field and the effect of varying the parameter are discussed. The observed magnetic islands and singular points are relevant in the fields of Plasma Physics and Space Physics, providing insights into magnetic structures in plasmas and their impact on confinement and stability. Furthermore, this study encourages innovation and equips researchers and students with the necessary tools to make meaningful contributions to the field, emphasizing the integration of scientific literature into physics education to promote a comprehensive understanding of physical concepts and their practical applications. series YoonLuis Yoon Lui s 2 that followup follow up YoonLui1 YoonLui Yoon-Lui- YoonLui3, YoonLui3 3, 3 Yoon-Lui-3 values presented distribution discussed stability Furthermore applications Yoon-Lui

Resumo A leishmaniose é uma zoonose de transmissão vetorial causada por diferentes espécies do gênero Leishmania, com amplo espectro clínico. É um problema de saúde pública agravado por uma série de limitações quanto ao tratamento. Na busca por novas alternativas terapêuticas, os venenos de escorpiões são uma fonte de moléculas multifuncionais que atuam contra a resistência natural dos patógenos. Este trabalho avaliou o potencial antileishmania dos venenos de Brotheas amazonicus e Tityus metuendus contra as formas promastigotas de Leishmania amazonensis e Leishmania guyanensis. Os venenos de B. amazonicus e T. metuendus foram avaliados quanto aos seus constituintes usando espectrometria no infravermelho por transformada de Fourier (FTIR). A inibição do crescimento e a morte de promastigotas foram avaliadas na presença de diferentes concentrações de veneno bruto (100 µg/mL, 50 µg/mL, 10 µg/mL, 1 µg/mL) após uma hora de incubação a 25 °C. Os espectros de FTIR de ambos os venenos exibiram bandas em regiões aproximadas, revelando que ambos exibem grupos funcionais semelhantes. O veneno bruto de ambas as espécies de escorpiões mostrou efeitos leishmanicidas semelhantes ou superiores ao antimoniato de N-metilglucamina padrão. Na maior concentração de 100 µg/mL, as culturas de L. guyanensis tratadas com o veneno de B. amazonicus apresentaram os maiores percentuais de mortalidade, acima de 28%, enquanto o veneno de T. metuendus apresentou a maior atividade contra L. amazonensis, com mortalidade acima de 7%. Este estudo preliminar demonstra que os venenos de B. amazonicus e T. metuendus podem ser ferramentas importantes na busca de novos fármacos contra a leishmaniose. O próximo passo envolve avaliar a atividade contra as formas amastigotas e purificar as proteínas do veneno para identificar os melhores candidatos anti-leishmania. clínico tratamento terapêuticas patógenos B T FTIR. . (FTIR) (10 µgmL µg mL µg/mL 5 2 C °C aproximadas Nmetilglucamina N metilglucamina padrão L 28 28% 7 7% antileishmania. anti leishmania. leishmania anti-leishmania (FTIR (1 (

Abstract Leishmaniasis is a vector-transmitted zoonosis caused by different species of the genus Leishmania, with a wide clinical spectrum. It is a public health problem aggravated by a series of limitations regarding treatment. In the search for new therapeutic alternatives, scorpion venoms are a source of multifunctional molecules that act against the natural resistance of pathogens. This work evaluated the antileishmanial potential of Brotheas amazonicus and Tityus metuendus venoms against the promastigote forms of Leishmania amazonensis e Leishmania guyanensis. The venoms of B. amazonicus and T. metuendus were evaluated for their constituents using Fourier Transform Infrared (FTIR). Growth inhibition and death of promastigotes were evaluated in the presence of diferente crude venom concentrations (100 µg/mL, 50 µg/mL, 10 µg/mL, 1 µg/mL) after one hour of incubation at 25 °C. The FTIR spectra of both venoms exhibited bands in approximate regions, revealing that both exhibit similar functional groups. Crude venom from both scorpion species showed similar or superior leishmanicidal effects to the standart drug N-methylglucamine antimoniate. At the highest concentration of 100 µg/mL, cultures of L. guyanensis treated with the venom of B. amazonicus showed the highest mortality percentages, above 28%, while T. metuendus venom showed the highest activity against L. amazonensis, with mortality above 7%. This preliminar study demonstrates that B. amazonicus and T. metuendus venoms can be important tools in the search for new drugs Against leishmaniasis. Next step involves evaluating the activity against the amastigote forms and purifying the venom proteins in order to identify the best anti-leishmania candidates. vectortransmitted vector transmitted spectrum treatment alternatives pathogens B T FTIR. . (FTIR) (10 µgmL µg mL µg/mL 5 2 C °C regions groups Nmethylglucamine N methylglucamine antimoniate L percentages 28 28% 7 7% leishmaniasis antileishmania anti leishmania candidates (FTIR (1 (

Resumo Os terpenóides, também chamados terpenos ou isoprenóides, são uma família de produtos naturais encontrados em todos os organismos vivos. Muitas plantas são produtoras destes metabolitos secundários, que constituem uma grande parte dos óleos essenciais. Uma das características mais importantes é que os compostos são voláteis, têm odor e podem ser utilizados numa variedade de aplicações em diferentes segmentos industriais ou na medicina tradicional. O Brasil tem uma flora rica e diversificada que pode ser utilizada como fonte de pesquisa para a obtenção de novas moléculas. Dentro desta flora, vale a pena mencionar a Caatinga como um bioma exclusivamente brasileiro que possui plantas adaptadas a uma série de condições climáticas e, portanto, um armazém de compostos a serem descritos. As infecções fúngicas são doenças cada vez mais comuns, devido a isso existe uma grande procura de novos agentes com baixa toxicidade e efeitos secundários. Os cientistas devem procurar novas moléculas que exibam atividade antifúngica para o desenvolvimento de novos medicamentos contra as infecções fúngicas. Esta revisão visa analisar dados científicos dos principais estudos publicados que descrevem o uso de terpenóides e as suas aplicações biológicas como antifúngicos. isoprenóides vivos secundários essenciais voláteis tradicional portanto descritos comuns antifúngicos

Abstract Terpenoids, also named terpenes or isoprenoids, are a family of natural products found in all living organisms. Many plants produce terpenoids as secondary metabolites, and these make up a large part of essential oils. One of most important characteristic is that the compounds are volatile, have odor and can be used in a variety of applications in different industrial segments and traditional medicine. Brazil has a rich and diverse flora that can be used as a source of research for obtaining new molecules. Within the Brazilian flora, it is worth mentioning the Caatinga as an exclusively Brazilian biome where plants adapt to a specific series of weather conditions and therefore become a great storehouse of the terpenoid compounds to be described herein. Fungal infections have become increasingly common, and a great demand for new agents with low toxicity and side effects has thus emerged. Scientists must search for new molecules exhibiting antifungal activity to develop new drugs. This review aims to analyze scientific data from the principal published studies describing the use of terpenes and their biological applications as antifungals. Terpenoids isoprenoids organisms metabolites oils volatile medicine herein common emerged drugs antifungals

Resumo O objetivo deste estudo foi determinar a toxicidade aguda dos óleos essenciais (OEs) de Aloysia triphylla, Lippia gracilis e Piper aduncum em juvenis de tambaqui (Colossoma macropomum), e avaliar as possíveis alterações histopatológicas em suas brânquias. Para os testes de toxicidade aguda, juvenis de tambaqui (n=24/tratamento) foram distribuídos em 6 tratamentos, com três repetições, sendo o controle e cinco concentração do OE de A. triphylla (60, 80, 100, 120 e 140 mg L-1), L. gracilis (35, 40, 45, 50 e 55 mg L-1) e P. aduncum (42,5, 45, 47,5, 50 e 52,5 mg L-1), com exposição de 4 h. A taxa de mortalidade e a severidade dos danos nas brânquias de tambaqui foram proporcionais ao aumento da concentração do OE, com os valores de CL50-4 h estimados em 109,57 mg L-1 para A. triphylla, em 41,63 mg L-1 para L. gracilis e em 48,17 mg L-1 para P. aduncum. Os principais danos morfológicos observados nas brânquias de tambaqui, expostos aos três OEs, foram os de grau I: hipertrofia e hiperplasia das células do epitélio lamelar, fusão lamelar, descolamento epitelial, dilatação e constrição capilar, proliferação de células de cloreto e de células mucosas e edema; em baixa frequência os de grau II como ruptura epitelial e aneurisma lamelar. Necrose (dano de grau III) foi observado somente nas lamelas branquiais expostas ao OE de P. aduncum (47,5, 50,0 e 52,5 mg L-1). Concentrações do OEs abaixo dos valores de CL50-4 h podem ser utilizados com parcimônia, em curtos períodos de exposição para o tratamento de doenças na criação de tambaqui. (OEs Colossoma macropomum, macropomum , macropomum) n=24/tratamento n24tratamento ntratamento n 24 (n=24/tratamento tratamentos repetições 60, 60 (60 80 100 12 14 L1, L1 L 1 35, 35 (35 40 45 5 P 42,5, 425 42 (42,5 475 47 47,5 525 52 52, CL504 CL CL50 CL50- 10957 109 57 109,5 L- 4163 41 63 41,6 4817 48 17 48,1 I lamelar capilar edema dano III (47,5 500 0 50, L1. . parcimônia 2 (6 8 10 3 (3 42,5 (42, 47, CL5 1095 109, 416 41, 481 48, (47, ( 42, (42 (47 (4

Abstract The aim of this study was to determine the acute toxicity of the essential oils (EOs) of Aloysia triphylla, Lippia gracilis and Piper aduncum in juvenile tambaqui (Colossoma macropomum), and evaluate the possible histopathological alterations in their gills. For the acute toxicity tests, juvenile tambaqui (n=24/treatment) were distributed in six treatments with three replicates, which comprised the control and five EO concentrations of A. triphylla (60, 80, 100, 120 and 140 mg L-1), L. gracilis (35, 40, 45, 50 and 55 mg L-1) and P. aduncum (42.5, 45, 47.5, 50 and 52.5 mg L-1), with an exposure period of 4 h. The mortality rate and severity of damage to the tambaqui gills were proportional to the increase in the concentration of the EO, with LC50-4 h values estimated at 109.57 mg L -1 for A. triphylla, 41.63 mg L -1 for L. gracilis and 48.17 mg L -1 for P. aduncum. The main morphological damages observed in the gills of the tambaqui exposed to the three EOs, were Grade I: hypertrophy and hyperplasia of lamellar epithelial cells, lamellar fusion, epithelial detachment, capillary dilation and constriction, proliferation of chloride cells and mucosal cells and edema; in low frequency Grade II damage as epithelial rupture and lamellar aneurysm. Necrosis (Grade III damage) was observed only in gill lamellae exposed to P. aduncum EO (47.5, 50.0 and 52.5 mg L-1). Concentrations of EOs below LC50-4 h can be used sparingly, for short periods of exposure for the treatment of diseases in tambaqui breeding. (EOs Colossoma macropomum, macropomum , macropomum) tests n=24/treatment n24treatment ntreatment n 24 (n=24/treatment replicates A 60, 60 (60 80 100 12 14 L1, L1 1 35, 35 (35 40 45 5 L-1 P 42.5, 425 42 (42.5 475 47 47.5 525 52 52. LC504 LC LC50 LC50- 10957 109 57 109.5 - 4163 41 63 41.6 4817 48 17 48.1 I fusion detachment constriction edema aneurysm (47.5 500 0 50. L1. . sparingly breeding 2 6 (6 8 10 3 (3 L- 42.5 (42. 47. LC5 1095 109. 416 41. 481 48. (47. ( 42. (42 (47 (4

This article provides a comprehensive review of relevant studies in the fields of plasma physics, electromagnetism, and space physics. The aim is to demonstrate how the study of the scientific literature can be used to enhance problem-solving abilities and develop innovative solutions in physics. In this paper, we focus on the study of solutions of the specific Grad-Shafranov equation. Two of the new solutions proposed by Yoon and Lui (2005) are used as a basis for the development of a new solution. The new solution presented has singular points similar to the Yoon-Lui-2 solution, but with an inverted configuration, and also presents less rounded double islands compared to the Yoon-Lui-2 solution. Additionally, the new solution does not exhibit the formation of a current ring, a characteristic of the Yoon-Lui-1 solution, and varying its parameters may lead to higher plasma confinement efficiency. In summary, we illustrate how a thorough analysis of literature can serve as a powerful means for generating innovative approaches to resolving theoretical issues in physics. physics electromagnetism problemsolving problem solving paper GradShafranov Grad Shafranov equation 2005 (2005 YoonLui2 YoonLui 2 Yoon-Lui- configuration Additionally ring YoonLui1 1 efficiency summary 200 (200 Yoon-Lui 20 (20 (2 (

Resumo Neste estudo investigamos a infecção por parasitos pulmonares na serpente Helicops angulatus. Encontramos quatro ninfas de pentastomídeos (Sebekia oxycephala) parasitando duas fêmeas adultas de H. angulatus oriundas do município de Rio Tinto, Paraíba, Brasil. A ocorrência das ninfas na serpente sugere que a transmissão ocorra através da cadeia trófica, uma vez que peixes atuam como hospedeiros intermediários do parasito e fazem parte da dieta H. angulatus . O resultado deste estudo representa o primeiro registro de pentastomídeos infectando H. angulatus. Sebekia oxycephala H Tinto Paraíba Brasil trófica

Abstract In this study, we investigated the infection by pulmonary parasites in the water snake Helicops angulatus. We found four nymphs of the pentastomide parasite Sebekia oxycephala, parasitizing two adult females H. angulatus collected in the municipality of Rio Tinto, Paraíba, Brazil. This occurrence is likely due to the nymphs of this parasite directly infecting aquatic intermediate hosts, such as fish. The result of this study represents the first record of pentastomid infecting H. angulatus. oxycephala H Tinto Paraíba Brazil hosts fish