RESUMO: Este estudo teve como objetivo avaliar os impactos do processamento térmico na composição química das sementes de jaca sua toxicidade. O teor de cinzas das sementes submetida à torra foi maior (3,21%) em comparação com as sementes nos outros tratamentos. No entanto, os teores de umidade (5,29%) e proteínas (10,49%) foram menores. O teor de proteínas apresentou diferença significativa (P≤ 0.05) entre os grupos estudados (10,49%). O teor de lipídeos foi menor nas sementes submetidas ao cozimento (1,13%), enquanto o teor de carboidratos apresentou diferença significativa (P ≤ 0.05) entre os grupos estudados (54,11%). As sementes brutas apresentaram o maior teor de fibras (25,20%). Em relação à toxicidade, apenas a farinha de sementes de jaca cozidas apresentou potencial citotóxico, embora nenhuma das amostras tenha causado irritação ou distúrbios vasculares em ovos fecundados. Esses resultados sugerem que o tratamento térmico pode garantir a segurança das sementes frente à citotoxicidade, embora reduza o teor de alguns macronutrientes. RESUMO toxicidade 3,21% 321 3 21 (3,21% tratamentos entanto 5,29% 529 5 29 (5,29% 10,49% 1049 10 49 (10,49% menores P≤ P 0.05 005 0 05 10,49%. . 1,13%, 113 1,13% , 1 13 (1,13%) 54,11%. 5411 54,11% 54 11 (54,11%) 25,20%. 2520 25,20% 25 20 (25,20%) citotóxico fecundados citotoxicidade macronutrientes 3,21 32 2 (3,21 5,29 52 (5,29 10,49 104 4 (10,49 0.0 00 1,13 (1,13% 541 54,11 (54,11% 252 25,20 (25,20% 3,2 (3,2 5,2 (5,2 10,4 (10,4 0. 1,1 (1,13 54,1 (54,11 25,2 (25,20 3, (3, 5, (5, 10, (10, 1, (1,1 54, (54,1 25, (25,2 (3 (5 (10 (1, (54, (25, ( (1 (54 (25 (2

ABSTRACT: This study evaluated the impacts of thermal processing on the chemical composition of jackfruit seeds and their toxicity. The ash content of the seeds subjected to roasting was higher (3.21%) compared to the seeds in the other treatments. However, the contents of moisture (5.29%) and protein (10.49%) were lower. The protein content showed a significant difference (P≤ 0.05) among the studied groups (10.49%). The lipid content was lower in the seeds subjected to cooking (1.13%), while the carbohydrate content showed a significant difference (P≤ 0.05) among the groups studied (54.11%). Raw seeds had the highest fiber content (25.20%). Regarding toxicity, only the cooked jackfruit seed flour showed cytotoxic potential. However, none of the samples caused irritation or vascular disorders in fertilized eggs. These results suggested that heat treatment can ensure the safety of seeds against cytotoxicity; although, it reduces the content of some macronutrients. ABSTRACT toxicity 3.21% 321 3 21 (3.21% treatments However 5.29% 529 5 29 (5.29% 10.49% 1049 10 49 (10.49% P≤ P (P 0.05 005 0 05 10.49%. . 1.13%, 113 1.13% , 1 13 (1.13%) 54.11%. 5411 54.11% 54 11 (54.11%) 25.20%. 2520 25.20% 25 20 (25.20%) potential eggs cytotoxicity although macronutrients 3.21 32 2 (3.21 5.29 52 (5.29 10.49 104 4 (10.49 0.0 00 1.13 (1.13% 541 54.11 (54.11% 252 25.20 (25.20% 3.2 (3.2 5.2 (5.2 10.4 (10.4 0. 1.1 (1.13 54.1 (54.11 25.2 (25.20 3. (3. 5. (5. 10. (10. 1. (1.1 54. (54.1 25. (25.2 (3 (5 (10 (1. (54. (25. ( (1 (54 (25 (2

Research to identify plant bioactive compounds led to the evolution of extraction methods. This study optimized ultrasound-assisted extraction (UAE) and microwave-assisted extraction (MAE) to extract the flavonoids of Croton grewioides Baill. species contributing to characterize the polar extract profile and understand the antioxidant potential of these plant constituents. The use of experimental design and statistical treatments enabled the determination of the ideal conditions for each technique. The extracts of five accessions of C. grewioides were obtained under the optimized extraction conditions and were analyzed using ultra high-resolution mass spectrometry (FT-Orbitrap MS) operating at negative ionization mode for flavonoids detection. The accurate experimental mass obtained to the main compounds was used to attribute the molecular formula. Chemical structures of the main compounds detected were proposed using structure data bases. Chemometric analysis were performed with two FT-Orbitrap MS spectra samples using the identified metabolites and, the antioxidant activity data, showing that for this species the MAE was most effective in extracting the antioxidant compounds. It was possible to propose the structures for forty compounds in the C. grewioides extracts, demonstrating the excellent performance of the FT-Orbitrap MS in providing information on the chemical profile of polar compounds in plant extracts. methods ultrasoundassisted ultrasound assisted UAE (UAE microwaveassisted microwave (MAE Baill constituents technique C highresolution high resolution FTOrbitrap FT Orbitrap detection formula bases

Abstract The iAtlantic Project has established an international collaborative strategy to improve mapping and characterization of deep and open ocean ecosystems in understudied regions of the Atlantic and evaluate their health. In December 2022, the first iAtlantic expedition in the South Atlantic set off to map and explore seafloor ecosystems in the Santos Basin slope (200-1,000 m depths) in collaboration with the Petrobras ‘Santos Basin - Regional Characterization Project.’ The 17-day ‘iAtlantic_BR10-Petrobras’ cruise was conducted on board the research vessel NPqHOc Vital de Oliveira (Brazilian Navy) and performed (a) water column structure characterization, (b) seafloor morphology mapping, (c) description of benthic habitats and communities by seafloor imagery and biological/ geological sampling, and (d) ex-situ experiments to assess the functioning of sedimentary ecosystems and their responses to climate-related environmental changes. This study describes the rationale behind the iAtlantic_BR10-Petrobras cruise science plan, reports its sampling strategy and methods, and summarizes its collected data and preliminary results. health 2022 2001,000 2001000 200 1,000 1 000 (200-1,00 depths Project. 17day day 17 ‘iAtlantic_BR10Petrobras iAtlanticBR10Petrobras iAtlanticBRPetrobras ‘iAtlantic_BR10 BR10 BR ‘iAtlantic_BR10-Petrobras Brazilian Navy a (a b (b c (c biological d (d exsitu ex situ climaterelated climate related changes iAtlantic_BR10Petrobras iAtlantic_BR10 plan methods results 202 2001 2001,00 200100 20 1000 1,00 00 (200-1,0 BR10Petrobras iAtlanticBR iAtlanticBR10 ‘iAtlantic_BR1 BR1 iAtlantic_BR1 2001,0 20010 2 100 1,0 0 (200-1, BRPetrobras iAtlanticBR1 ‘iAtlantic_BR iAtlantic_BR 2001, 10 1, (200-1 (200- (200 (20 (2 (

Resumen: Los efectos adversos de la profilaxis preexposición (PrEP) oral con fumarato de disoproxilo de tenofovir son barreras para el inicio y la continuación de la PrEP. Aunque los efectos graves son raros y predecibles, la evidencia de esta evaluación entre hombres que tienen sexo con hombres (HSH) y mujeres transgénero (MTG) sigue siendo limitada. Este estudio evalúa los efectos adversos de la PrEP oral diaria en HSH y MTG. Se trata de una revisión sistemática y un metaanálisis de ensayos clínicos y cohortes que demuestran el uso de la PrEP oral diaria seleccionada de las bases de datos PubMed/MEDLINE, Embase, LILACS y Cochrane CENTRAL. La recolección de datos incluyó efectos adversos y cambios en los marcadores renales y hepáticos. Se utilizaron modelos de efectos aleatorios para resumir el riesgo de efectos adversos a lo largo del estudio. La heterogeneidad se evaluó mediante la prueba Q de Cochran y la inconsistencia (I2). El riesgo de sesgo y la certeza de la evidencia se evaluaron utilizando las recomendaciones de la Colaboración Cochrane. Se identificaron 653 referencias. De estas, se seleccionaron diez. Todos los estudios evaluaron los marcadores renales de elegibilidad y los marcadores hepáticos. El uso diario de la PrEP oral no se asoció con eventos de grado 3 o 4 (RR = 0,99; IC95%: 0,83-1,18; I2 = 26,1%), con ningún evento adverso grave (RR = 1,04; IC95%: 0,58-1,87; I2 = 88,4%), con creatinina de grado 3 o 4 (RR = 0,66; IC95%: 0,24-1,84; I2 = 79,9%) y con hipofosfatemia de grado 3 o 4 (RR = 0,56, IC95%: 0,15-2,10). La certeza de la evidencia varió de alta a moderada para los resultados analizados. La PrEP oral diaria es segura y bien tolerada por HSH y MTG. Los efectos adversos fueron mínimos y se distribuyeron uniformemente entre la intervención y el control. Resumen (PrEP predecibles (HSH MTG (MTG limitada PubMedMEDLINE PubMed MEDLINE PubMed/MEDLINE Embase CENTRAL hepáticos I2. I . (I2) 65 referencias estas diez RR 0,99 099 0 99 IC95% IC95 IC 0,831,18 083118 0,83 1,18 83 1 18 0,83-1,18 26,1%, 261 26,1% , 26 26,1%) 1,04 104 04 0,581,87 058187 0,58 1,87 58 87 0,58-1,87 88,4%, 884 88,4% 88 88,4%) 0,66 066 66 0,241,84 024184 0,24 1,84 24 84 0,24-1,84 79,9% 799 79 9 056 56 0,56 0,152,10. 015210 0,15 2,10 15 2 10 0,15-2,10) analizados control (I2 6 0,9 09 IC9 831 0,831,1 08311 083 0,8 118 1,1 8 0,83-1,1 26,1 1,0 581 0,581,8 05818 058 0,5 187 1,8 5 0,58-1,8 88,4 0,6 06 241 0,241,8 02418 024 0,2 184 0,24-1,8 79,9 7 05 152 0,152,10 01521 015 0,1 210 2,1 0,15-2,10 (I 0, 0,831, 0831 08 11 1, 0,83-1, 26, 0,581, 0581 0,58-1, 88, 0,241, 0241 02 0,24-1, 79, 0,152,1 0152 01 21 2, 0,15-2,1 0,831 0,83-1 0,581 0,58-1 0,241 0,24-1 0,152, 0,15-2, 0,83- 0,58- 0,24- 0,152 0,15-2 0,15-

Resumo: Os efeitos adversos da profilaxia pré-exposição (PrEP) oral com fumarato de tenofovir desoproxila são barreiras para o início e a continuidade da PrEP. Embora os efeitos graves sejam raros e previsíveis, as evidências dessa avaliação entre homens que fazem sexo com homens (HSH) e mulheres transgênero (MTG) ainda são limitadas. Este estudo avalia os efeitos adversos da PrEP oral diária em HSH e MTG. Trata-se de uma revisão sistemática e metanálise de ensaios clínicos e coortes que demonstram o uso de PrEP oral diária selecionados nas bases de dados PubMed/MEDLINE, Embase, LILACS e Cochrane CENTRAL. A extração de dados incluiu os efeitos adversos e alterações nos marcadores renais e hepáticos. Modelos de efeitos aleatórios foram usados para resumir o risco de efeitos adversos ao longo do estudo. A heterogeneidade foi avaliada pelo teste Q de Cochran e inconsistência (I2). O risco de viés e a certeza da evidência foram avaliados por meio das recomendações da Colaboração Cochrane. Foram identificadas 653 referências. Destes, dez foram selecionadas. Todos os estudos avaliaram marcadores renais de elegibilidade e marcadores hepáticos. O uso diário de PrEP oral não foi associado a eventos de grau 3 ou 4 (RR = 0,99; IC95%: 0,83-1,18; I2 = 26,1%), a qualquer evento adverso grave (RR = 1,04; IC95%: 0,58-1,87; I2 =88,4%), à creatinina grau 3 ou 4 (RR = 0,66; IC95%: 0,24-1,84; I2 = 79,9%) e à hipofosfatemia grau 3 ou 4 (RR = 0,56; IC95%: 0,15-2,10). A certeza das evidências variou de alta a moderada para os desfechos analisados. A PrEP oral diária é segura e bem tolerada por HSH e MTG. Os efeitos adversos foram mínimos e distribuídos uniformemente entre a intervenção e o controle. Resumo préexposição pré exposição (PrEP previsíveis (HSH MTG (MTG limitadas Tratase Trata se PubMedMEDLINE PubMed MEDLINE PubMed/MEDLINE Embase CENTRAL hepáticos I2. I . (I2) 65 referências Destes selecionadas RR 0,99 099 0 99 IC95% IC95 IC 0,831,18 083118 0,83 1,18 83 1 18 0,83-1,18 26,1%, 261 26,1% , 26 26,1%) 1,04 104 04 0,581,87 058187 0,58 1,87 58 87 0,58-1,87 =88,4%, 884 =88,4% 88 =88,4%) 0,66 066 66 0,241,84 024184 0,24 1,84 24 84 0,24-1,84 79,9% 799 79 9 0,56 056 56 0,152,10. 015210 0,15 2,10 15 2 10 0,15-2,10) analisados controle (I2 6 0,9 09 IC9 831 0,831,1 08311 083 0,8 118 1,1 8 0,83-1,1 26,1 1,0 581 0,581,8 05818 058 0,5 187 1,8 5 0,58-1,8 =88,4 0,6 06 241 0,241,8 02418 024 0,2 184 0,24-1,8 79,9 7 05 152 0,152,10 01521 015 0,1 210 2,1 0,15-2,10 (I 0, 0,831, 0831 08 11 1, 0,83-1, 26, 0,581, 0581 0,58-1, =88, 0,241, 0241 02 0,24-1, 79, 0,152,1 0152 01 21 2, 0,15-2,1 0,831 0,83-1 0,581 0,58-1 =88 0,241 0,24-1 0,152, 0,15-2, 0,83- 0,58- =8 0,24- 0,152 0,15-2 0,15-

Abstract: The adverse effects of oral pre-exposure prophylaxis (PrEP) using tenofovir disoproxil fumarate are barriers to PrEP initiation and continuation. Although serious effects are rare and predictable, evidence for this assessment among men who have sex with men (MSM) and transgender women (TGW) is still limited. This study assesses the adverse effects of daily oral PrEP in MSM and TGW. This is a systematic review and meta-analysis of clinical trials and cohort studies on the use of daily oral PrEP selected from the PubMed/MEDLINE, Embase, LILACS, and Cochrane CENTRAL databases. Data extraction included adverse effects and changes in renal and hepatic markers. Random effects models were used to summarize the risk of adverse effects throughout the study. Heterogeneity was assessed using the Cochran’s Q test and the inconsistency test (I2). The risk of bias and the certainty of the evidence were assessed using the Cochrane Collaboration recommendations. The search identified 653 references. Of these, 10 were selected. All studies assessed the eligibility of renal and hepatic markers. The use of daily oral PrEP was not associated with grade 3 or 4 adverse events (RR = 0.99; 95%CI: 0.83-1.18; I2 = 26.1%), any serious adverse event (RR = 1.04; 95%CI: 0.58-1.87; I2 = 88.4%), grade 3+4 creatinine level (RR = 0.66; 95%CI: 0.24-1.84; I2 = 79.9%), and grade 3 or 4 hypophosphatemia (RR = 0.56; 95%CI: 0.15-2.10). The certainty of the evidence ranged from high to moderate for the outcomes analyzed. Daily oral PrEP is safe and well tolerated by MSM and TGW. Adverse effects were minimal and evenly distributed between intervention and control. Abstract preexposure pre exposure (PrEP continuation predictable (MSM TGW (TGW limited metaanalysis meta analysis PubMedMEDLINE PubMed MEDLINE PubMed/MEDLINE Embase LILACS databases markers Cochrans Cochran s I2. I . (I2) recommendations 65 references these 1 RR 0.99 099 0 99 95%CI 95CI CI 95 0.831.18 083118 0.83 1.18 83 18 0.83-1.18 26.1%, 261 26.1% , 26 26.1%) 1.04 104 04 0.581.87 058187 0.58 1.87 58 87 0.58-1.87 88.4%, 884 88.4% 88 88.4%) 34 3+ 0.66 066 66 0.241.84 024184 0.24 1.84 24 84 0.24-1.84 79.9%, 799 79.9% 79 9 79.9%) 0.56 056 56 0.152.10. 015210 0.15 2.10 15 2 0.15-2.10) analyzed control (I2 6 0.9 09 831 0.831.1 08311 083 0.8 118 1.1 8 0.83-1.1 26.1 1.0 581 0.581.8 05818 058 0.5 187 1.8 5 0.58-1.8 88.4 0.6 06 241 0.241.8 02418 024 0.2 184 0.24-1.8 79.9 7 05 152 0.152.10 01521 015 0.1 210 2.1 0.15-2.10 (I 0. 0.831. 0831 08 11 1. 0.83-1. 26. 0.581. 0581 0.58-1. 88. 0.241. 0241 02 0.24-1. 79. 0.152.1 0152 01 21 2. 0.15-2.1 0.831 0.83-1 0.581 0.58-1 0.241 0.24-1 0.152. 0.15-2. 0.83- 0.58- 0.24- 0.152 0.15-2 0.15-

Abstract Morinda citrifolia, commonly known as noni, is a plant belonging to the Rubiaceae family. This plant has a high biological potential, which has different biological properties, including antioxidant, antibacterial, antiviral, antifungal, antitumor and anti-inflammatory. In this work, the immunomodulatory, antitumor and antimicrobial activities of lignin isolated from Morinda citrifolia leaves were investigated. The results showed that this lignin was not cytotoxic and that it was able to promote activation and differentiation of immune cells in addition to inducing the production of anti-inflammatory cytokines. Furthermore, it was able to inhibit the growth of different tumor and microbial cells in vitro. This pioneering study on these different activities shows that the lignin isolated in this study can be used as a raw material to obtain biomedical and pharmaceutical products. noni family potential properties antioxidant antibacterial antiviral antifungal antiinflammatory. antiinflammatory anti inflammatory. inflammatory work immunomodulatory investigated cytokines Furthermore vitro products

ABSTRACT Given the heterogeneity of soils in Roraima state, Brazil, and the need for a phosphorus (P) extraction protocol, this study aimed to assess the efficiency of the Mehlich-1, Mehlich-3, Bray-1 extractants and anion exchange resin (AER) in determining available P in soils representative of the state. The chemical, physical and mineralogical attributes of seven soil classes were determined. The experiment was conducted in a greenhouse, using a randomized block design in a 7 x 5 factorial scheme with four repetitions. The first factor was the soils (LA (ITÃ), LV (ITÃ), LA (SERRA DA PRATA), LA (CCA), PA (CCA), FT (BONFIM), SN (SURUMU)), and the second P doses, estimated based on the maximum P-adsorption capacity (MPAC). A polyethylene pot containing 5 dm3 of soil and five plants was defined as the experimental unit. The indicator species was corn grown in two 30-day phases. The P doses were applied using monopotassium phosphate. Soil samples were removed before planting to determine available P using the extractants. Corn dry weight was assessed at the end of the two-phase experiment. Correlation tests were performed for dry weight versus extractant and extractant versus extractant. The Mehlich-3 and Bray-1 extractants were the most sensitive to variations in soil attributes. The resin exhibited the greatest correlations with the different soils individually and combined, showing potential in determining available P in soils from the humid tropical region of the Brazilian Amazon. state Brazil (P protocol Mehlich1, Mehlich1 Mehlich 1, 1 Mehlich-1 Mehlich3, Mehlich3 3, 3 Bray1 Bray Bray- AER (AER chemical determined greenhouse repetitions ITÃ, ITÃ , (ITÃ) SERRA PRATA, PRATA PRATA) CCA, CCA (CCA) BONFIM, BONFIM (BONFIM) SURUMU, SURUMU (SURUMU)) Padsorption adsorption MPAC. MPAC . (MPAC) dm unit 30day day 30 phases phosphate twophase phase Mehlich- combined Amazon (ITÃ (CCA (BONFIM (SURUMU) (MPAC (SURUMU

Resumen: Los efectos adversos de la profilaxis preexposición (PrEP) oral con fumarato de disoproxilo de tenofovir son barreras para el inicio y la continuación de la PrEP. Aunque los efectos graves son raros y predecibles, la evidencia de esta evaluación entre hombres que tienen sexo con hombres (HSH) y mujeres transgénero (MTG) sigue siendo limitada. Este estudio evalúa los efectos adversos de la PrEP oral diaria en HSH y MTG. Se trata de una revisión sistemática y un metaanálisis de ensayos clínicos y cohortes que demuestran el uso de la PrEP oral diaria seleccionada de las bases de datos PubMed/MEDLINE, Embase, LILACS y Cochrane CENTRAL. La recolección de datos incluyó efectos adversos y cambios en los marcadores renales y hepáticos. Se utilizaron modelos de efectos aleatorios para resumir el riesgo de efectos adversos a lo largo del estudio. La heterogeneidad se evaluó mediante la prueba Q de Cochran y la inconsistencia (I2). El riesgo de sesgo y la certeza de la evidencia se evaluaron utilizando las recomendaciones de la Colaboración Cochrane. Se identificaron 653 referencias. De estas, se seleccionaron diez. Todos los estudios evaluaron los marcadores renales de elegibilidad y los marcadores hepáticos. El uso diario de la PrEP oral no se asoció con eventos de grado 3 o 4 (RR = 0,99; IC95%: 0,83-1,18; I2 = 26,1%), con ningún evento adverso grave (RR = 1,04; IC95%: 0,58-1,87; I2 = 88,4%), con creatinina de grado 3 o 4 (RR = 0,66; IC95%: 0,24-1,84; I2 = 79,9%) y con hipofosfatemia de grado 3 o 4 (RR = 0,56, IC95%: 0,15-2,10). La certeza de la evidencia varió de alta a moderada para los resultados analizados. La PrEP oral diaria es segura y bien tolerada por HSH y MTG. Los efectos adversos fueron mínimos y se distribuyeron uniformemente entre la intervención y el control.

Abstract: The adverse effects of oral pre-exposure prophylaxis (PrEP) using tenofovir disoproxil fumarate are barriers to PrEP initiation and continuation. Although serious effects are rare and predictable, evidence for this assessment among men who have sex with men (MSM) and transgender women (TGW) is still limited. This study assesses the adverse effects of daily oral PrEP in MSM and TGW. This is a systematic review and meta-analysis of clinical trials and cohort studies on the use of daily oral PrEP selected from the PubMed/MEDLINE, Embase, LILACS, and Cochrane CENTRAL databases. Data extraction included adverse effects and changes in renal and hepatic markers. Random effects models were used to summarize the risk of adverse effects throughout the study. Heterogeneity was assessed using the Cochran’s Q test and the inconsistency test (I2). The risk of bias and the certainty of the evidence were assessed using the Cochrane Collaboration recommendations. The search identified 653 references. Of these, 10 were selected. All studies assessed the eligibility of renal and hepatic markers. The use of daily oral PrEP was not associated with grade 3 or 4 adverse events (RR = 0.99; 95%CI: 0.83-1.18; I2 = 26.1%), any serious adverse event (RR = 1.04; 95%CI: 0.58-1.87; I2 = 88.4%), grade 3+4 creatinine level (RR = 0.66; 95%CI: 0.24-1.84; I2 = 79.9%), and grade 3 or 4 hypophosphatemia (RR = 0.56; 95%CI: 0.15-2.10). The certainty of the evidence ranged from high to moderate for the outcomes analyzed. Daily oral PrEP is safe and well tolerated by MSM and TGW. Adverse effects were minimal and evenly distributed between intervention and control.

Resumo: Os efeitos adversos da profilaxia pré-exposição (PrEP) oral com fumarato de tenofovir desoproxila são barreiras para o início e a continuidade da PrEP. Embora os efeitos graves sejam raros e previsíveis, as evidências dessa avaliação entre homens que fazem sexo com homens (HSH) e mulheres transgênero (MTG) ainda são limitadas. Este estudo avalia os efeitos adversos da PrEP oral diária em HSH e MTG. Trata-se de uma revisão sistemática e metanálise de ensaios clínicos e coortes que demonstram o uso de PrEP oral diária selecionados nas bases de dados PubMed/MEDLINE, Embase, LILACS e Cochrane CENTRAL. A extração de dados incluiu os efeitos adversos e alterações nos marcadores renais e hepáticos. Modelos de efeitos aleatórios foram usados para resumir o risco de efeitos adversos ao longo do estudo. A heterogeneidade foi avaliada pelo teste Q de Cochran e inconsistência (I2). O risco de viés e a certeza da evidência foram avaliados por meio das recomendações da Colaboração Cochrane. Foram identificadas 653 referências. Destes, dez foram selecionadas. Todos os estudos avaliaram marcadores renais de elegibilidade e marcadores hepáticos. O uso diário de PrEP oral não foi associado a eventos de grau 3 ou 4 (RR = 0,99; IC95%: 0,83-1,18; I2 = 26,1%), a qualquer evento adverso grave (RR = 1,04; IC95%: 0,58-1,87; I2 =88,4%), à creatinina grau 3 ou 4 (RR = 0,66; IC95%: 0,24-1,84; I2 = 79,9%) e à hipofosfatemia grau 3 ou 4 (RR = 0,56; IC95%: 0,15-2,10). A certeza das evidências variou de alta a moderada para os desfechos analisados. A PrEP oral diária é segura e bem tolerada por HSH e MTG. Os efeitos adversos foram mínimos e distribuídos uniformemente entre a intervenção e o controle.

ABSTRACT Although acerola (Malpighia emarginata D.C.) has been suggested to be a climacteric fruit, little is known about its sensitivity to exogenous ethylene. The objective of the study was to evaluate the quality changes of acerola fruit at two harvest maturity stages in response to external ethylene application. ‘Flor Branca’ and ‘Junko’ acerolas were harvested at the maturity stages 1 (green fruit with density>1 g cm-3) and 2(green fruit with density <1 g cm-3) and were treated with 0 or 1,000 µL L-1 of ethylene for 24 hours at 12 ºC.The fruit were stored at 12 ºC with relative humidity of 90-95% for 14 days. Both cultivars harvested at the maturity stage 2 showed skin color change from green to red during storage, which was not observed in fruit harvested at the maturity stage 1.External ethylene had no effect on 'Flor Branca' and 'Junko' acerolas respiration rate, flesh firmness, skin color, weight loss, soluble solids (SS), titratable acidity (AT), SS/AT ratio, and ascorbic acid contents. The classification of green acerolas by density was an effective approach to determine fruit harvest maturity for fresh consumption. Malpighia D.C. DC D C application Flor Branca ‘Junko Junko density1 density> cm3 cm 3 cm-3 2green < 1000 000 1,00 L1 L L- ºCThe 9095% 9095 90 95% 95 90-95 days storage 1External External 'Junko rate firmness loss SS, SS , (SS) AT, AT (AT) SSAT ratio contents consumption D.C cm- 100 00 1,0 909 9 90-9 (SS (AT 10 1, 90-

Resumo Por que os atores políticos promovem a transparência pública? Estudos mostram que a adesão à transparência pode ser tanto politicamente estratégica, ou seja, para atar as mãos do sucessor, quanto resultado da observação da adoção da política feita por outros municípios, isto é, para minimizar o custo da informação. Testamos as motivações políticas e informacionais para explicar a adoção de leis de transparência com uma análise subnacional da difusão da LAI nos municípios brasileiros (2011-2019). Os resultados mostram que tanto o aprendizado quanto as motivações da estratégia política afetam a probabilidade de adoção da LAI. Fatores socioeconômicos também são importantes fatores explicativos. No entanto, uma análise dos efeitos heterogêneos mostra que o mecanismo de aprendizagem é relevante para reduzir o impacto dos fatores socioeconômicos. Isso significa que aprender com os vizinhos minimiza o custo da informação e a dependência de fatores estruturais para promover a transparência em nível local.

Abstract Why do political actors promote public transparency? Studies show that adherence to transparency can be both politically strategic, i.e., to tie the hands of the successor, and a result of observing the adoption of the policy made by other municipalities, i.e., to minimize the cost of information. We test both the political and the informational motivations to explain the adoption of transparency laws with a subnational analysis of the diffusion of LAI in Brazilian municipalities (2011-2019). Results show that both the informational and the political strategy motivations affect the probability of adopting the LAI. Socioeconomic factors are also important explanatory factors. However, an analysis of heterogeneous effects shows that the learning mechanism is relevant for reducing the impact of socioeconomic factors. This means that learning from neighboring municipalities minimizes the cost of information and the reliance on structural factors to promote transparency at the local level.

Resumen ¿Por qué los actores políticos promueven la transparencia pública? Los estudios muestran que la adhesión a la transparencia puede ser tanto políticamente estratégica, es decir, para atar las manos del sucesor, como resultado de la observación de la adopción de la política hecha por otros municipios, esto es, para minimizar el costo de la información. Probamos las motivaciones políticas e informativas para explicar la adopción de leyes de transparencia con un análisis subnacional de la difusión de la LAI en los municipios brasileños (2011-2019). Los resultados muestran que tanto las motivaciones de aprendizaje como las de estrategia política afectan la probabilidad de adopción de la LAI. Los factores socioeconómicos también son factores explicativos importantes. Sin embargo, un análisis de los efectos heterogéneos muestra que el mecanismo de aprendizaje es relevante para reducir el impacto de los factores socioeconómicos. Esto significa que aprender de los vecinos minimiza el costo de la información y la dependencia de factores estructurales para promover la transparencia a nivel local.

RESUMO: Este estudo teve como objetivo avaliar a estrutura da vegetação e o desempenho de novilhas em recria e vacas de descarte em pastagens naturais manejadas em sistema de pastejo rotacionado com lotes “ponta” e “rapador” no período primavera-verão. Os tratamentos foram diferentes intervalos de descanso de 402 e 252 graus-dia (GD), os quais favorecem o crescimento de gramíneas de diferentes grupos funcionais. O delineamento experimental foi em blocos ao acaso com dois tratamentos e três repetições. Os animais de teste foram 24 novilhas no grupo “ponta” e 24 vacas no grupo “rapador”. No estrato entre touceiras, as alturas do pasto maiores que 16 cm foram predominantes em ambos os tratamentos, sendo 1.3 vezes mais frequente no tratamento 402 GD em relação ao tratamento 252 GD. A taxa de lotação média foi 22% maior no tratamento com 252 GD. Embora não tenham sido observadas diferenças para o ganho médio diário de novilhas (0,227 kg.dia-1) e vacas (0,336 kg.dia-1) entre os tratamentos, o ganho de peso por área no período experimental foi maior no tratamento 252 GD. Apesar do sistema de manejo com lotes “ponta” e “rapador” não proporcionar mudanças significativas na estrutura da pastagem, ele permite atingir metas de desempenho satisfatórias em áreas de pastagens naturais.

ABSTRACT: This study evaluated the structure of vegetation and the performance of rearing heifers and cull cows in Campos grasslands managed in the rotational stocking method with first-last stocking in the spring-summer period. The treatments were different rest intervals of 402 and 252 degrees-day, which favor the growth of different functional groups of grasses. A completely randomized block design with two treatments and three repetitions was used. The test animals were 24 heifers in the “first” group and 24 cows in the “last” group. In the stratum between tussock grasses, sward heights greater than 0.16 m were predominant in both treatments, it was 1.3 times more frequent in the 402 DD treatment compared to the 252 DD treatment. Average stocking rate was 22% higher in the 252 DD treatment. Although, no differences were observed for the average daily gain of heifers (0.227 kg.day-1) and cows (0.336 kg.day-1) between treatments, the weight gain per area in the experimental period was greater in the 252 DD treatment. Despite the management system with first and last stoking does not provide significant changes in the structure of the pasture, it allowed to achieve satisfactory performance goals in areas of Campos grassland.

Considering the bicentenary of Brazil’s Independence in 2022 and that this year was proclaimed by UNESCO as the International Year of Basic Sciences for Sustainable Development, in mid-2021 the Brazilian Chemical Society (SBQ) launched the “Post 2022 Chemistry Movement - Sustainability and Sovereignty”, with the main goal of promoting different activities so that chemistry contributes for the sustainable development and sovereignty of Brazil in the coming years. One of these activities is the proposal of an action plan, with goals to be achieved by 2030 and 2050. This article describes in detail how this action plan was formulated by a working group, with the help of an advisory council and interviews of 18 professionals from universities, the government, industries, the third sector and other organizations. Mimicking the Agenda 2030 SDGs, the resulting action plan is based on two broad Chemistry Sustainable Development Goals: promoting sustainability through chemistry in basic education, and promoting sustainability in the industry and university through science, technology, innovation, and education (STI&E) in chemistry. After the definition of three driving technological challenges in STI&E, they shall be successively implemented through different actions starting in 2023 yet.

ABSTRACT Introduction: Alcohol consumption is a complex and multifactorial health-related problem. Risk and/or protective factors and risk perception may act as modulating variables of alcohol consumption. Objective: To explore the relationship between protective and/or risk factors, risk perception and alcohol consumption in Cuban university students. Material and Methods: A quantitative non-experimental cross-sectional ex post facto correlation study was conducted. A total of 1,377 university students participated in the study. The instruments used included the Experiential Self-Report, a questionnaire for the evaluation of protective factors of mental health in university students, a questionnaire for the evaluation of risk perception of alcohol consumption, and the Alcohol Use Disorders Identification Test. Descriptive and inferential statistics were used to analyze the relationships between the different variables. Results: Men showed greater difficulties in the adequacy of risk perception and higher alcohol consumption than women. Highly significant relationships were established between risk perception, protective factors, alcohol consumption and other sociodemographic variables included in the study such as academic year, the condition of being granted a scholarship, and area of residence. A direct relationship between the development of protective factors and risk perception and an inverse relationship between the latter and alcohol consumption were found in university students. Conclusions: The relationship between risk and protective factors, risk perception and alcohol consumption in university students was analyzed. Introducción: El consumo de alcohol constituye un problema de salud, complejo y multifactorial. Los factores de riesgo y/o protección y la percepción de riesgo pudieran actuar como variables moduladoras del consumo de alcohol.

RESUMEN Introducción: El consumo de alcohol constituye un problema de salud, complejo y multifactorial. Los factores de riesgo y/o protección y la percepción de riesgo pudieran actuar como variables moduladoras del consumo de alcohol. Objetivo: Explorar la relación entre los factores de protección y/o riesgo, la percepción de riesgo y el consumo de alcohol en estudiantes universitarios cubanos. Material y Métodos: Se asumió la metodología cuantitativa con un diseño no experimental transversal (ex-post-facto) con un alcance correlacional. Participaron 1 377 estudiantes universitarios. Se utilizaron como instrumentos el Autorreporte Vivencial, Cuestionario para la evaluación de factores protectores de la salud mental en estudiantes universitarios, Cuestionario para la evaluación de la percepción de riesgo sobre consumo de alcohol y el Cuestionario para la identificación de trastornos asociados con el alcohol. Se empleó la estadística descriptiva e inferencial para analizar las relaciones entre las diferentes variables. Resultados: Los hombres mostraron mayores dificultades en la adecuación de la percepción de riesgo y un mayor consumo de alcohol que las mujeres. Se establecieron relaciones altamente significativas entre la percepción de riesgo, los factores de protección, el consumo de alcohol y otras variables sociodemográficas incluidas en el estudio como el año académico, la condición de ser becado y la zona de residencia. Se encontró una relación directa entre el desarrollo de los factores de protección y la percepción de riesgo y una relación inversa entre esta última y el consumo de alcohol en los estudiantes universitarios. Conclusiones: Se analizó, de forma exploratoria, la relación entre los factores de riesgo y protección, la percepción de riesgo y el consumo de alcohol en estudiantes universitarios.

Abstract The use of creep feeding for preweaning piglets is important to improve the performance of the piglets. The objective of this experiment was evaluate the effect of using or altering the position of piglet’s creep feeder during lactation on piglet’s performance and on behavior of piglets and sows kept in a hot climate environment. Forty-five sows and their litters at 10 days of lactation were randomly distributed into three treatments: front feeder (FF) - near the side of the sow’s head; back feeder (BF) - near the side of the rump of the sow; and no feeder (NF). All piglets were weighed individually to evaluate the average weight, weight gain and coefficient of variation of the weight. Behavior assessments of the piglets and sows were recorded in 3 period. At 15 and 21 d, piglets of the FF treatment were heavier (P ≤ 0.0001) than piglets of the other treatments. At 10-21d piglets of FF treatment had 76.2% less belly nosing behavior than the NF piglets (P=0.015). The treatments had no impact on behavior of the sows. The creep feeders positioned in the front of the farrowing crate increased piglet growth rate and decreased frequency of belly nosing behavior.

RESUMO: O estudo objetivou avaliar o efeito de dois intervalos de descanso entre pastoreios nas características estruturais do pasto e desempenho de novilhas de corte em pastagens naturais manejadas em pastejo rotativo. Os tratamentos foram dois intervalos entre pastejos de 375 e 750 GD (graus dia), baseados na soma térmica da duração de elongação foliar média de gramíneas de grupos de captura e conservação dos recursos dominantes de uma pastagem natural. O experimento foi conduzido no período de outubro de 2015 a março de 2016, com duração de 151 dias e os períodos experimentais divididos em primavera e verão. Foram utilizadas 24 novilhas teste da raça Braford, com idade inicial na média de 12 meses, e de peso corporal médio de 220 kg (± 27,8). A Massa de forragem total (FMt) pré-pastejo foi em média de 3791 kgMSha-1 e não diferiu entre tratamentos e estação, o mesmo ocorreu com a FM de estrato não touceira. A taxa de lotação média foi de 469 kgha-1 em ambos os tratamentos. O ganho médio diário variou apenas entre estações, com médias de 0,102 kganimal-1dia-1 na primavera e 0,372 kganimal-1dia-1 no verão. O ganho por área durante os 151 dias de avaliação foi em média de 103 kgha-1. As pastagens naturais submetidas a intervalos de descanso entre pastoreios baseados na elongação foliar de gramíneas dominantes, independente do tratamento utilizado, proporcionam ritmos de ganhos médios diários compatíveis com a meta de peso corporal, a ser atingida aos 24 meses, para que as novilhas possam ser acasaladas.

ABSTRACT: This study aimed to evaluate the effect of two rest intervals between grazing on the structural characteristics of pasture and performance of beef heifers in Campos grassland under rotational grazing. The treatments were two intervals between 375 and 750 DD (degree-days) grazing, based on the cumulative thermal sum for leaf expansion of native grasses belonging to capture and conservation groups of resources dominant in a natural grassland. The experiment was conducted during 151 days from October 2015 to March 2016, and twenty-four Braford heifers tests mean age = 12 months; mean body weight = 220kg (± 27.8) were used. The pre-grazing total forage mass (FMt) was on average 3791 kgMSha-1 and did not differ between treatments and season, the same occurred with the non-tussock FM. The average stocking rate was 469 kg ha-1 in both treatments. The average daily gain varied only between seasons, 0.102 kg animal-1 day-1 during spring and 0.372 kg animal-1 day-1 during summer. During the 151 evaluation days, the gain per area was a 103 kgha-1. The use of rest intervals between grazing based on the leaf elongation of dominant grasses, when applied to the areas of Campos grasslands, provided nutritional conditions to reach the target body weight for breeding 24 months old beef heifers.