The catalytic oxidation of glycerol was investigated in assays with palladium-silver bimetallic nanoparticles (Pd-Ag) immobilized on cobalt ferrite (CoFe2O4). Bimetallic nanoparticles were prepared by the galvanic replacement method, immobilized on CoFe2O4 by wet impregnation. Bimetallic Pd-Ag nanoparticles with 35 wt.% Pd content effectively catalyzed the selective oxidation reaction of glycerol to glyceraldehyde. Catalytic oxidation was carried out at 60-80 °C for 2-4 h in an aqueous NaOH solution (NaOH:glycerol ratio = 4 mol:mol) under O2 pressure of 4 bar; the selectivity of glyceraldehyde reached 99.35% and the conversion of glycerol of 49.07% at a temperature of 60 °C and a reaction time of 2 h. Glyceric acid and traces of tartronic acid and mesoxalic acid were also detected. The catalyst was also very stable, showing activity up to 4 runs without significant loss of activity and selectivity. palladiumsilver palladium silver PdAg Ag (Pd-Ag CoFe2O4. CoFeO . CoFe O (CoFe2O4) method CoFe2O impregnation 3 wt wt. 6080 80 60-8 C 24 2- NaOHglycerol molmol mol mol:mol bar 9935 99 99.35 4907 49 07 49.07 6 detected stable (CoFe2O4 608 8 60- 993 9 99.3 490 0 49.0 (CoFe2O 99. 49.

Supported Au-Pd nanoparticles (NPs) have been extensively studied in alcohol oxidation reactions. However, few studies use reducible metal oxides as support, which can activate oxygen molecules and boost the selectivity of the reaction. In this work, Au-Pd NPs were supported on α-MoO3 and evaluated in the selective oxidation of cinnamyl alcohol without solvent. The Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, and X-ray photoemission spectroscopy (XPS) analyses showed that the catalyst is richer in oxygen vacancies than the support, being probably responsible for the stability of the NPs (average size 4.62 ± 0.15 nm) and the high conversion and selectivity for the oxidation of cinnamyl alcohol. Furthermore, experiments have shown that the Au:Pd molar ratio influences the catalytic performance and can be optimized by controlling temperature, pressure, and reaction time. The catalyst proved to be active and selective for cinnamaldehyde in short reaction times. It showed satisfactory performance at 30 min and its best activity at 1 h with 94% conversion and 87% selectivity, without loss of activity and selectivity after four runs under the same reaction conditions. AuPd Au Pd (NPs reactions However support work αMoO3 αMoO α MoO3 MoO α-MoO solvent FTIR, FTIR , (FTIR) Xray X ray XPS (XPS average 462 4 62 4.6 015 0 15 0.1 nm Furthermore temperature pressure time times 3 94 87 conditions (FTIR 46 6 4. 01 0. 9 8

Abstract Introduction: subarachnoid hemorrhage (SAH) is a rare and life-threatening cerebrovascular disease. Mitigating the factors that compromise patient recovery during neurocritical care due to SAH is of clinical benefit. Objectives: to evaluate the nutritional risk of patients with aneurysmal subarachnoid hemorrhage using “The Modified Nutrition Risk in the Critically Ill” (mNUTRIC) score, and examine its association with outcomes such as mortality, time of mechanical ventilation, and functional status among survivors. Methods: we designed a cross-sectional study. Patients with SAH admitted to the neurointensive critical care unit (neuroICU) in a tertiary care public hospital were eligible. The inclusion criteria were a minimum stay in the intensive care unit (ICU) of 24 hrs for subarachnoid hemorrhage from a nontraumatic, spontaneously ruptured cerebral aneurysm, and hospital admission within 24 hrs after the onset of symptoms. Results: high nutritional risk as stratified by the mNUTRIC score was associated with discharge type (OR = 0.346; 95 % CI = 0.182-0.650; p = 0.001), acute hypertensive hydrocephalus (OR = 4.371; 95 % CI = 2.283-8.549; p < 0.001), and functional outcome (OR = 0.106; 95 % CI = 0.025-0.0388; p < 0.001). The mNUTRIC score was significantly different among median age (p < 0.001), length of stay in the neuroICU (p = 0.005), SOFA score (p < 0.001), and APACHE II score (p < 0.001) categories. Conclusions: this study demonstrated an association between nutritional risk assessment and outcomes such as length of stay in the neuroICU, type of discharge, functional status, and mortality prediction accuracy.

Resumen Introducción: la hemorragia subaracnoidea es una forma rara de enfermedad cerebrovascular que pone en peligro la vida del paciente. Reducir los factores que comprometen la recuperación de los pacientes durante los cuidados neurocríticos tiene benefício clínico. Objetivo: evaluar el riesgo nutricional de los pacientes con hemorragia subaracnoidea por aneurisma utilizando la puntuación “The Modified Nutrition Risk in the Critically Ill” (mNUTRIC) y su asociación con resultados como la mortalidad, el tiempo de ventilación mecánica y el estado funcional entre los supervivientes. Método: diseñamos un estudio transversal. Fueron elegibles los pacientes con hemorragia subaracnoidea ingresados en la unidad de cuidados críticos neurointensivos (neuroUCI) de un hospital público de atención terciaria. Los criterios de inclusión fueron una permanencia mínima de 24 horas en la UCI, hemorragia subaracnoidea por rotura espontánea no traumática de aneurisma cerebral, e ingreso hospitalario en las 24 horas siguientes al inicio de los síntomas. Resultados: el alto riesgo nutricional estratificado por la puntuación mNUTRIC se asoció con el tipo de alta (OR = 0,346; IC 95 % = 0,182-0,650; p = 0,001), la hidrocefalia hipertensiva aguda (OR = 4,371; IC 95 % = 2,283-8,549; p < 0,001) y el resultado funcional (OR = 0,106; IC 95 % = 0,025-0,0388; p < 0,001). La puntuación mNUTRIC presentó diferencias estadísticamente significativas entre las medianas de edad (p < 0,001), duración de la permanencia en la neuroUCI (p = 0,005), puntuación SOFA (p < 0,001) y puntuación APACHE II (p < 0,001). Conclusión: este estudio demuestra una asociación de la evaluación del riesgo nutricional con resultados como la necesidad de ventilación mecánica, la duración de la permanencia en la neuroUCI, el tipo de alta, el estado funcional y la precisión en la predicción de la mortalidad.

A catalyst comprised of SnO2 impregnated on ZnO nanowires, which presented remarkable ability to catalyze fatty acid esterification/transesterification reactions, is reported. For optimization of reaction conditions, artificially acidified soybean oil with 10 wt.% oleic acid was used as a model feed. The optimized conditions were: 150 °C, 6 h, 5 g of oil, catalyst concentration of 5%, and methanol:oil molar ratio of 15:1. The catalyst achieved 92% of total fatty acid methyl esters (FAME) content and was used five times without the necessity of catalyst washing from one reaction to the other. Then, such conditions were applied to produce biodiesel from the oil extracted from Scenedesmus sp. microalgae; the system reached 72% of FAME content, without any previous refining or degumming process of the oil. Rietveld refinement, X-ray diffraction, elemental mapping in scanning transmission electron microscopy, X-ray photoelectron spectroscopy, and pyridine-desorption Fourier-transform infrared spectroscopy were used to characterize the material.

Abstract This work aimed to obtain thermoplastic starch composites (TPS) derived from starch and fibers of babassu coconut. The (TPS) was prepared with 40% plasticizer (glycerol). The fibers underwent chemical treatment of alkalinization and bleaching. SEM images and infrared spectra showed that wax, lignin, and hemicellulose were removed from the fiber surface. SEM images of TPS starch showed a smooth and uniform surface, whereas images of the TPSWF composite (washed fiber) showed voids between the fiber and the TPS. This phenomenon was not observed in the SEM images of the composites TPSAF (alkalized fiber) and TPSBF (bleached fiber). The tensile strength and elastic modulus of the composites were higher than the pure TPS matrix. Concerning elongation, composites underwent less elongation than TPS. The mechanical properties found for the TPSWF and TPSAF composites do not differ. However, the mechanical properties of the TPSBF composite were better than the properties of the other composites.

AuPd nanoparticles have gained substantial attention due to their application in selective oxidation of alcohols. However, due to the radical nature of the oxidation of benzyl alcohol, under specific conditions, even without a catalyst, the reaction occurs and affects the selectivity of the system. Therefore, we aimed to develop a catalyst that enables the control of the oxidation leading to higher reaction selectivity. To accomplish this, we have prepared a catalytic support comprised of CoFe2O4 nanoparticles impregnated with Sr(OH)2 that presented a significant control of the reaction selectivity without any metal or external base addition. After the impregnation of AuPd nanoparticles in a specific ratio, the reaction reached a selectivity of > 99% for benzaldehyde, in 3.5 h, with a recycle regime of five runs without loss of activity and selectivity. Our results show that the judicious choice of the ratio of the metals prevents the necessity of manipulating the reaction conditions to improve the performance of the system. Additionally, studies under N2 and O2 environments, with or without water, confirmed the role of the O2 in the system. Holding all this information, we propose a possible mechanism for the prepared system.

We have prepared, by a sol-immobilization method, bimetallic catalysts with different Au:Pt atomic ratios supported on commercial SrCO3. The catalytic performance for the oxidation reaction of benzyl alcohol of such materials was compared to the monometallic counterparts, aiming at the obtaining of the best composition of the material. It was found that the Au:Pt atomic ratio presents a remarkable effect on the system performance, i.e., Pt-rich systems are more selective; however, less active. Thus, an equilibrium related to the activity and selectivity of the system was obtained by considering the yield of the system. Also, some density functional theory (DFT) insights were obtained by using a cluster of 14 atoms of Au and 1 or 2 atoms of Pt. X-ray photoelectron spectroscopy, elemental mapping in scanning transmission electron microscopy before and after catalyst usage, flame atomic absorption spectroscopy, Rietveld refinement, among other techniques, were used and associated to the experimental data, which allowed us to propose a catalytic mechanism for the system, which was important since SrCO3 has not been considered before as catalyst support for alcohol oxidation reactions.

The synthesis of efficient and reusable gold-based catalysts for the selective oxidation of alcohols is a strategy for the development of green processes. Pre-formed nanoparticles syntheses are an easy way to produce controlled-nanosized gold materials; however, the selection of a support is not trivial. Herein, we proposed a CoFe2O4 support enriched with Sr(OH)2, which holds remarkable properties and is suitable for the synthesis of a stable gold-based catalyst for the oxidation of benzyl alcohol. We suggested that the interaction between the CoFe2O4 and the Sr(OH)2 is highly important for the performance of the catalyst. Under the base-free condition of 2.5 h, 100 ºC and 2 bar of O2, the catalyst reached 58% of conversion with 76% of selectivity to benzaldehyde. With K2CO3 addition, the conversion and selectivity to benzaldehyde increased to 87% and 88%, respectively. Any gold leaching was detected in 5 successive runs, attesting the noticeable stability that the catalyst presents. This work provides great potential for the selective oxidation of alcohols with high activity since the magnetic properties of the catalyst provide an easy route and allows the separation of the medium reaction. In addition, we are here proposing an important interaction between the Sr(OH)2 and the magnetic nanoparticles.

Microalgae lipid-derived biofuels is considered promising candidates for substitution of petroleum-based energy sources. However, the lipid extraction from the algal biomass stands as a challenge due to its low yields and cost-intensive cell disruption procedures. In this study a multivariate optimization of the extraction conditions was suggested, aiming a maximization of the lipid extraction from Scenedesmus sp. microalgae grown using wastewater as a nutrient medium. The extraction method, extraction time, solvent mixture and pretreatment were considered between upper and lower levels in order to access their significance, including their interactions, on the experimental response, while using a reduced number of experiments. The studies were performed using low-cost extraction methods (magnetic stirring and ultrasonication). The optimal extraction condition was obtained using CHCl3:MeOH (2:1) solvent mixture, in a 2-hour extraction period using ultrasonication. Fatty acid profiles of extracted lipids were also evaluated.

Hyperbranched biopolymers is an important class of polymer that is used in different areas, mainly in biomedicine. AB2 monomers are crucial to the development of a "hyperbranched" architecture of polyglycerol, being glycidol the most commonly used, even considering its environmental hazard. Glycerol carbonate is an ecologically accepted monomer synthesized directly from glycerol, and the chosen for the studies herein. In literature, no studies described the use of glycerol and cyclic carbonates to prepare hyperbranched polymers. This work describes the obtainment of hyperbranched polymers using glycerol and TMP salt as core-initiator and glycerol carbonate and propylene carbonate as monomers. The polymers were characterized by FTIR, NMR, MALDI-TOF and TEM. NMR spectroscopy showed linear, dendritic, and terminal units of hyperbranched polymer. The degree of branching PGLYGC and PTMPGC was 0.669 and 0.667, respectively. The molecular weight of PTMCGC, PTMPPC, PGLYPC was found and compared with MALDI. The molar mass was not different from the calculated by Inverse Gated. These polymers have enormous potential as drug delivery and an environmentally correct synthetic route due to the substitution of glycidol by biocompatible monomers.

This work described a new magnetic material enriched with strontium as catalyst to produce babassu biodiesel. The use of magnetic materials has attracted attention due to easy and fast separation from reaction medium. Moreover, they are ecologically correct, due to they generate less discards to the environment. Techniques of analysis and characterization were carried out to check the synthesis of magnetite and strontium ferrite, besides to verify the presence of hydroxide and carbonate in the structure of the strontium oxide. The best catalytic activities presented conversions of 78.6% and 89.7% when using the catalysts SrO/Fe3O4 and SrO/SrFe2O4, respectively. Density studies of the alkali active sites were performed to elucidate the best activity for the catalyst composed with SrFe2O4.

Solid state reaction of serpentinite Mg3Si2O5(OH)4 with NaOH was investigated to produce new NaMgSi oxide phases with basic properties for application in catalysis. X-ray powder diffraction (XRD) showed that NaOH impregnated on serpentinite, specially 20% sodium and treated at 700 ºC (20Na700), led to the formation of a new crystalline phase Na2Mg2Si2O7. This solid state reaction is discussed in terms of a first step involving Na+ diffusion and intercalation in the interlayer space of the serpentinite structure followed by a dihydroxylation and formation of the NaMgSi oxides. Temperature programmed reaction and desorption experiments with 20Na700 combined with XRD suggested a strong basicity with high CO2 uptake likely due to diffusion and interaction with the basic sites in the material structure. These materials were tested as catalysts for the transesterification of soybean oil with methanol. The obtained results are discussed in terms of a basic site Si-O-Na+ present in the in the Na2Mg2Si2O7 structure.

RESUMO Objetivo: Estabelecer se há superioridade entre os critérios para predizer desfecho clínico desfavorável na lesão renal aguda e nefropatia induzidas por contraste. Métodos: Estudo retrospectivo conduzido em hospital terciário com 157 pacientes submetidos à infusão de contraste radiológico para fins propedêuticos. Resultados: Cumpriram os critérios para inclusão 147 pacientes. Aqueles que cumpriram os critérios de lesão renal aguda induzida por contraste (59) também cumpriram os critérios para nefropatia induzida por contraste (76); 44,3% dos pacientes cumpriram os critérios para o estadiamento pelo sistema KDIGO; 6,4% dos pacientes necessitaram utilizar terapia de substituição renal, e 10,7% dos pacientes morreram. Conclusão: O diagnóstico de nefropatia induzida por contraste foi o critério mais sensível para determinar a necessidade de terapia de substituição renal e óbito, enquanto o KDIGO demonstrou a maior especificidade; na população avaliada, não houve correlação entre o volume de contraste e a progressão para lesão renal induzida por contraste, nefropatia induzida por contraste, diálise de suporte ou óbito.

ABSTRACT Objective: To establish whether there is superiority between contrast-induced acute kidney injury and contrast-induced nephropathy criteria as predictors of unfavorable clinical outcomes. Methods: Retrospective study carried out in a tertiary hospital with 157 patients undergoing radiocontrast infusion for propaedeutic purposes. Results: One hundred forty patients fulfilled the inclusion criteria: patients who met the criteria for contrast-induced acute kidney injury (59) also met the criteria for contrast-induced nephropathy (76), 44.3% met the criteria for KDIGO staging, 6.4% of the patients required renal replacement therapy, and 10.7% died. Conclusion: The diagnosis of contrast-induced nephropathy was the most sensitive criterion for renal replacement therapy and death, whereas KDIGO showed the highest specificity; there was no correlation between contrast volume and progression to contrast-induced acute kidney injury, contrast-induced nephropathy, support dialysis or death in the assessed population.

It is presented herein heterogeneous catalysts comprised of strontium and nickel oxides synthesized using a coprecipitation method. They were applied for the preparation of biodiesel from macaw palm oil. The catalysts were characterized by X-ray diffraction (XRD), adsorption and desorption of nitrogen by Brunauer-Emmett-Teller (BET) and Barrett-Joyner-Halenda (BJH) methods, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and differential thermogravimetric analysis (TG-DTA). The conversion was determined by gas chromatography with flame detector (GC-FID). The best activity was obtained when the catalyst was calcined at 1100 °C for 3 hours. The highest conversion was reached (97%) when the following conditions were used: 5 hours, 2% of metal loading, 65 °C and oil/alcohol molar ratio of 1:9.

RESUMO Descrevemos paciente de 27 anos com síndrome de Coffin-Lowry, com quadro de pneumonia comunitária grave, choque séptico e insuficiência respiratória. Sumarizamos a assistência ventilatória mecânica, bem como o período de internação em unidade de terapia intensiva.

ABSTRACT We describe a 27-year-old patient with Coffin-Lowry syndrome with severe community pneumonia, septic shock and respiratory failure. We summarize both the mechanical ventilatory assistance and the hospitalization period in the intensive care unit.