ABSTRACT Unvaccinated identical twins developed bilateral anterior uveitis soon after the onset of coronavirus disease 2019 symptoms. During follow-up, both patients developed choroiditis, and one twine developed posterior scleritis and serous retinal detachment. Prompt treatment with oral prednisone ameliorated the lesions, and no recurrence was observed at the 18-month follow-up. Choroiditis may rarely be associated with severe acute respiratory syndrome coronavirus 2 infection, and it responds well to corticosteroid therapy. Although the exact mechanism is unknown, we hypothesize that the virus may act as an immunological trigger for choroiditis. 201 symptoms followup, followup follow up, up follow-up choroiditis detachment lesions 18month month 18 followup. up. infection therapy unknown 20 1

ABSTRACT Purpose: This study aimed to evaluate the total macular thickness as well as the thickness of the inner and outer retinal layers in patients with Parkinson’s disease. It also aimed to verify the correlation of these parameters with motor symptoms and cognitive function. Methods: A total of 46 eyes of 23 patients with Parkinson’s disease and 40 eyes of 20 healthy controls were included in the study. The patients’ cognitive, functional, and nonmotor symptoms were evaluated using the Katz Index of Independence and Pfeffer’s Activities of Daily Living, Mini-Mental State Examination, Frontal Assessment Battery, Schwab and England Staging Scales, and Movement Disorders Society Nonmotor Symptoms Scale. The macular thickness measurements obtained via total, inner, and outer optical coherence tomography were recorded. Furthermore, the correlation of the parameters of optical coherence tomography with cognitive, functional, and nonmotor symptoms was assessed. Results: The scores of the Katz Index of Independence and Pfeffer’s Activities of Daily Living as well as the Movement Disorders Society Nonmotor Symptoms Scale were significantly lower in patients with Parkinson’s disease than in healthy controls. Moreover, the former had greater total macular thickness. The temporal and inferior outer sectors were significantly greater for the ganglion cell complex thickness in patients. A significant correlation was observed between the total macular thickness and the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale, Parte III (MDS-UPDRS-III) values. Contrarily, there was a negative correlation between the outer macular thickness and the MDS-UPDRS-III values. Meanwhile, the total macular thickness and ganglion cell complex thickness were significantly correlated with the scores of the Mini-Mental State Examination, Schwab and England Staging Scale, Frontal Assessment Battery, and Katz Index of Independence and Pfeffer’s Activities of Daily Living. In addition, the Schwab and England scale was correlated with the outer macular thickness. Conclusion: The total and inner macular thicknesses at the temporal and inferior outer sectors were greater in patients with Parkinson’s disease than in the control group. These findings indicate that macular thickness may be greater in those with Parkinson’s disease, particularly when associated with mild motor symptoms. In addition, the parameters of the total, inner, and outer optical coherence tomography were significantly associated with motor and nonmotor symptoms as well as cognitive function impairment. Purpose Parkinsons Parkinson s Methods 4 2 functional Pfeffers Pfeffer MiniMental Mini Mental Examination Battery Scales recorded Furthermore assessed Results Moreover SocietyUnified Unified MDSUPDRSIII MDS UPDRS (MDS-UPDRS-III values Contrarily Meanwhile addition Conclusion group impairment

ABSTRACT Optic neuritis is an important cause of unilateral and acute visual loss in young adults, but other differential diagnoses should be considered, especially when the disease has an atypical presentation. This report presents the case of a young woman with reduced visual acuity in her right eye, associated with optic disc edema and a relative afferent pupillary defect, that was initially misdiagnosed as optic neuritis and subsequently found to have paracentral acute middle maculopathy, possibly secondary to subtle impending central retinal vein occlusion. This case emphasizes the need to remember that retinal vascular diseases can occasionally mimic optic neuritis. Detailed anamnesis and ophthalmic examination can avoid unnecessary interventions. adults considered presentation eye defect maculopathy occlusion interventions

Abstract In this paper, the application of AI and machine learning (ML) to the study of wireless propagation channels is investigated in two parts: first, an artificial neural network model is used to improve path loss prediction, and then, a pattern recognition model using multilayer perceptron (MLP) networks is used to identify and remove impulsive noise in power delay profiles (PDP). These studies were conducted based on field measurements in the 2400 MHz band in a public square with vegetation. The results are analyzed and compared with ordinary least squares (OLS) nonlinear regression results and results from similar studies. The Root Mean Square Error (RMSE) values between the experimental results of mean path loss and those provided by each propagation model are presented. The adjustment performed by OLS nonlinear regression and ANN significantly reduced the RMSE. The best results are those presented by artificial neural networks, with RMSE of 0.39 when using four neurons in the hidden layer of the ANN. The ANN used to identify and remove impulsive noise in power delay profiles (PDP) through pattern recognition proved to be more efficient than the CFAR technique. ANN technique found a larger number of valid multipaths compared to the CFAR technique. paper ML (ML parts first prediction then MLP (MLP PDP. PDP . 240 vegetation (OLS (RMSE 039 0 39 0.3 (PDP 24 03 3 0. 2

Resumen Los desastres tienen el poder de causar profundos impactos socioeconómicos en la sociedad y aumentar el riesgo social. El beneficio eventual es una medida de protección social para prevenir y promover el enfrentamiento de situaciones ajenas a la vida cotidiana, como un desastre. En este sentido, ¿cuál es el papel del beneficio eventual en un contexto de desastre? Este artículo tiene como principal objetivo verificar el papel del beneficio eventual en situaciones de desastre en Brasil. Además, está estructurado en tres objetivos específicos: a) discutir cómo se vinculan los principios de seguridad jurídica y de la prohibición del retroceso social a la provisión del beneficio eventual; b) describir cómo se estructura el beneficio eventual en el sistema legal brasileño; c) analizar cómo es la provisión del beneficio eventual en una situación de desastre. Para responder a esta pregunta, la investigación utiliza el método de investigación documental de artículos y libros científicos en el ámbito del derecho constitucional y la seguridad social. Los resultados indican que el beneficio eventual no se resume en un monto económico, sino en un conjunto de ayudas destinadas a cubrir las necesidades existentes de una población en un escenario de desastre.

Abstract Disasters can lead to social and economic losses and a sharp increase in social risks. The ‘benefício eventual’ is a social protection measure whose aim is to prevent vulnerability and to respond to social risks in unpredictable situations, such as disasters. In this sense, what is the role of the ‘benefício eventual’ in the context of disasters? The main objective of this study is to verify the role of ‘benefício eventual’ in disaster situations in Brazil. To provide a more detailed approach on the research process, this investigation has three specific objectives: a) discuss the convergences between the principles of legal security and the prohibition of retrogression related to the provision of the ‘benefício eventual’; b) describe the legislation of the ‘benefício eventual’; c) analyze how the ‘benefício eventual’ is provided during a disaster. This research uses the documentary analysis of constitutional and social security legislation, academic papers, and books. The results indicate that the ‘benefício eventual’ is not merely an amount of money, but a set of policies to fulfill population’s needs after a disaster.

Résumé L’impact socioéconomique des catastrophes et autres désastres est énorme sur la société et aggrave les risques sociaux. Afin d’en atténuer les effets, a été conçu ce que l’on désigne sous les termes de bénéfice éventuel, défini comme une mesure de protection sociale visant à préparer et à former la population si elle est confrontée à des situations sans aucun rapport avec la vie quotidienne, comme les désastres. Dans ce contexte, quel rôle le bénéfice éventuel occupe-t-il lorsque l’on a affaire à un désastre? Cette étude a pour principal objectif celui de vérifier le rôle joué par le bénéfice éventuel lorsque des catastrophes ont eu lieu au Brésil. Divisée en trois parties, on y aborde plus spécifiquement les thèmes suivants: a) une interrogation sur les liens associant les principes de sécurité juridique et le rejet de toute régression sociale qui sont sous-entendus par ce que l’on nomme les bénéfices éventuels ; b) une description de la structure desdits bénéfices dans le système légal au Brésil; c) une analyse sur l’apport du bénéfice éventuel lors de désastres. Pour parvenir à ce but, ce travail a eu recours à la méthode de recherche documentaire à partir d’articles et d’ouvrages scientifiques, plus précisément ceux dont la réflexion utilise des outils propres au droit constitutionnel et à la sécurité sociale. Les résultats montrent que le bénéfice éventuel ne se résume pas simplement à une aide économique mais se caractérise aussi par un ensemble de mesures visant à faire face aux besoins réels de la population victime d’un désastre.

RESUMO A disseminação metastática ocular de tumores sistêmicos é incomum, ocorrendo principalmente na coroide e em pacientes idosos. O câncer de pulmão é considerado o principal tumor metastático ocular em homens, contudo, outras doenças oculares, como as uveítes e lesões retinianas, podem mimetizar os implantes secundários tumorais nos tecidos oculares. O aspecto fundoscópico das neoplasias da coroide pode apresentar similaridade com outros processos infecciosos, especialmente o tuberculoma de coroide. Dessa forma, a investigação clínica detalhada é de grande importância no diagnóstico de pacientes com massas coroideanas, especialmente quando configuram a primeira manifestação de uma doença sistêmica e grave. Relatamos um caso raro de metástase coroideana como primeira manifestação clínica do carcinoma de células renais em um homem jovem, mimetizando um tuberculoma de coroide. incomum idosos homens contudo oculares retinianas infecciosos forma coroideanas grave jovem

ABSTRACT Ocular metastases from systemic tumors are uncommon. The choroid is the most frequent target, with a preference for elderly individuals. Lung cancer is the predominant primary tumor that metastasizes to the eyes in males, although other ocular conditions such as uveitis and retinal lesions can mimic secondary tumor implants in ocular tissues. On fundoscopy, choroidal metastasis resembles other infectious processes, especially choroidal tuberculoma. Therefore, patients presenting with choroidal masses should undergo detailed clinical examinations, especially if the mass is the first manifestation of a systemic and severe disease. In this report, we describe a young man with a metastatic choroidal tumor secondary to papillary renal cell carcinoma mimicking a unilateral choroidal tuberculoma. uncommon target individuals males tissues fundoscopy processes tuberculoma Therefore examinations disease report

RESUMO Relatamos um caso de uma paciente de 54 anos com hipertensão intracraniana que apresentava achados atípicos de papiledema unilateral e vasculopatia polipoidal da coroide peripapilar. A investigação levou ao diagnóstico de hipertensão intracraniana idiopática e de um pequeno meningioma incidental. A paciente foi tratada com acetazolamida por via oral, seguida de três injeções intravítreas mensais de bevacizumabe, resultando em inatividade da vasculopatia polipoidal da coroide, redução da exsudação e completa absorção do líquido subretiniano. A apresentação deste caso serve para documentar pela primeira vez vasculopatia polipoidal da coroide associada a papiledema. Ele também demonstra que podem ocorrer anormalidades vasculares da coroide mesmo quando o edema do disco óptico é unilateral, uma manifestação incomum do aumento da pressão intracraniana. O reconhecimento imediato desses achados e seu manejo adequado são essenciais para o tratamento adequado e para prevenção da perda visual irreversível.

ABSTRACT We have reported here the case of a 54-year-old woman with intracranial hypertension that presented with the unique features of unilateral papilledema and peripapillary polypoidal choroidal vasculopathy. Our investigations lead to the diagnosis of idiopathic intracranial hypertension and an incidental small right frontal meningioma. The patient was accordingly treated with oral acetazolamide, followed by three consecutive monthly intravitreal injections of bevacizumab, which resulted in the inactivation of the polypoidal choroidal vasculopathy, marked reduction of lipid exudation, and complete absorption of the subretinal fluid. This case serves as the first documentation of polypoidal choroidal vasculopathy associated with papilledema. It also demonstrates that choroidal vascular abnormalities may occur even when optic disk edema is unilateral, which is an uncommon manifestation of increased intracranial pressure. Prompt recognition of such findings and its appropriate management are essential for adequate treatment and prevention of irreversible visual loss.

RESUMO Um policial de 39 anos se queixava de diminuição bilateral da visão central nos últimos 2 anos. A acuidade visual era 20/40 e 20/400 no olho direito (OD) e esquerdo (OE) e a fundoscopia revelou lesão macular hipopigmentada bilateral. A angiografia fluoresceínica e com indocianina verde revelaram, respectivamente, vazamento do corante e áreas hiperintensas nas regiões maculares. A tomografia de coerência óptica evi denciou fluido sub-retiniano no OD e escavação focal de coroide do tipo conformacional no OE. Após 4 meses, a escavação focal de coroide mudou de conformacional para não conformacional e, aos 12 meses, reverteu para conformacional associado a atrofia incompleta do epitélio pigmentar da retina e da retina externa na região da escavação. Também foi evidenciado paquicoroide, sem neovascularização. Relatamos pela primeira vez uma escavação focal de coroide que evoluiu de conformacional para não conformacional e, em seguida, retornou à configuração primária (conformacional) em um paciente com coriorretinopatia serosa central bilateral.

ABSTRACT A 39-year-old policeman complained of decreased bilateral central vision over the last two years. On examination, visual acuity was 20/40 and 20/400 in the right (OD) and left eye (OS), respectively, and fundoscopy revealed a bilateral hypopigmented macular lesion. Fluorescein and indocyanine green angiography demonstrated leakage and hyperintense spots, respectively, within the macular areas. At baseline, optical coherence tomography showed subretinal fluid in the OD and a conforming focal choroidal excavation in the OS. Focal choroidal excavation converted from conforming to nonconforming type at 4-month follow-up and then reversed to conforming type at 12-month follow-up, and was associated with incomplete retinal pigment epithelium and outer retina atrophy over the area of excavation. Pachyvessels were also evidenced in the choroid, without neovascularization. We report for the first time a case of focal choroidal excavation that progressed from conforming to nonconforming type and then reverted to its primary configuration (conforming type) in a patient with concurrent bilateral central serous chorioretinopathy.

RESUMO Paciente de 45 anos, sexo feminino queixava-se de hiperemia e dor no olho direito há sete dias. Encontrava-se sob investigação de alterações urinárias e relatou história pregressa de úlceras orais e hiperemia ocular bilateral recorrentes. A acuidade visual corrigida era de 20/30 no olho direito e 20/20 no esquerdo. A biomicroscopia da superfície ocular do olho direito revelou intensa hiperemia escleral em região nasal que persistiu após a instilação de fenilefrina tópica a 10%, reforçando o diagnóstico clínico de esclerite anterior unilateral. A biópsia renal revelou a presença de imunocomplexos de IgA e confirmou a hipótese de doença de Berger. Uma terapia imunossupressora de manutenção com azatioprina após 6 meses de indução de remissão com ciclofosfamida foi necessária após pulsoterapia com metilprednisolona. A esclerite geralmente está relacionada a doenças autoimunes sistêmicas, como artrite reumatoide e poliangeite. Descrevemos aqui um caso raro de esclerite anterior unilateral associada à doença de Berger.

ABSTRACT A 45-year-old female patient presented with a complaint of right eye redness and pain for 7 days. She was under investigation for urinary abnormalities and reported a previous history of recurrent oral ulcers and ocular hyperemia in both eyes. Best-corrected visual acuity was 20/30 and 20/20 in the right and left eyes, respectively. Slit-lamp biomicroscopy of the ocular surface of the right eye revealed nasal scleral hyperemia that persisted after instillation of topical phenylephrine 10%, reinforcing the diagnosis of anterior scleritis. Renal biopsy showed immunoglobulin A immune complexes and confirmed the suspected diagnosis of Berger's disease. Maintenance immunosuppressive therapy with azathioprine following a 6-month induction of remission with cyclophosphamide was necessary after pulse therapy with methylprednisolone. Scleritis is usually related to systemic autoimmune diseases, such as rheumatoid arthritis, and polyangiitis. Herein, we describe a rare case of unilateral anterior scleritis associated with Berger's disease.

Resumo: A economia atual vem exigindo das organizações maior qualidade em suas operações, sendo necessário atentar a não conformidade dos processos que geram gastos e esforços extras e, influenciam a satisfação dos clientes. Diante disso, o presente artigo tem como objetivo compreender as principais causas de retornos de produtos do mercado em uma empresa de cosméticos. Munindo-se da literatura e da aplicação da ferramenta da qualidade FMEA (Análise de Modos de Falha e Efeitos) no estudo de caso, avaliam-se as soluções e seus efeitos na organização. Após estudos realizados foram propostas novas soluções e sugestões de estudos na redução da logística reversa pós-venda da organização.

Abstract: The current economy has demanded from organizations greater quality in their operations, which makes necessary to avoid non-compliance of processes that generate extra expenses, efforts and influence satisfaction of clients. This article aims to understand main causes of products returns from market in a cosmetics company. Based on literature review and application of a quality tool, FMEA (Failure Modes and Effects Analysis), in the case study, solutions and their effects on the organization are evaluated. After studies, new solutions and suggestions were proposed to reduce organization's post-sale reverse logistics.

RESUMO O objetivo desse estudo foi investigar o processo de formação de jovens futebolistas amazonenses. Participaram do estudo 53 jovens futebolistas (15,3?1,27 anos) recrutados a partir de escolas e clubes futebol do Amazonas. Foi utilizado o Questionário do Histórico de Participação para identificar os contextos de prática em que os futebolistas mais estiveram engajados durante o seu processo de formação (macro-estrutura de prática) e foram filmadas três sessões de treino, visando contabilizar o tempo destinado para cada uma das categorias de tarefas utilizadas pelo treinador (training form, playing form and inactivity) (micro-estrutura de prática). Foi possível identificar diferenças estatisticamente significativas entre os diferentes contextos de prática, onde os jogadores permaneceram um maior tempo engajados em uma prática deliberada, quando comparado com o jogo deliberado (p<0.001) e competição (p<0.001). Quanto às análises das sessões de treino, foi possível constatar que os jogadores tendem a ter mais contatos com tarefas descontextualizadas. Com essas informações, é possível concluir estes jogadores seguiram um percurso formativo caracterizado por uma iniciação esportiva precoce, bem como não tiveram acesso à contextos de treino representativos, de modo a potencializar a formação de jogadores inteligentes e criativos.

ABSTRACT The present study aimed to investigate youth soccer players’ development in Amazonas state. Fifty-three young soccer players participated in this study (15,3?1,27 years). Participation History Questionnaire was used to investigate the different practice contexts that Amazonas soccer players were engaged during their development process (macro-structure of practice). We also observed three training sessions and calculated the time allotted for each type of training tasks used by the coach (training form, playing form and inactivity) (micro-structure of practice). It was possible to observe that soccer players from Amazonas state accumulated more time engaged in deliberate practice than deliberate play (p<0.001) and competition (p<0.001). We also observed that players had higher contact with decontextualized tasks (training form activities) during their training sessions. With this information, it can be concluded that these soccer players followed an early specialization pathway and didn’t have contact with a more representative learning environment, in an attempt to improve the development of intelligent and creative players.

RESUMO Paciente de 65 anos, sexo feminino, foi encaminhada para avaliação de cirurgia de catarata. Relatou história de cirurgias mandibulares para correção de deformação facial desenvolvida ao longo da infância e adolescência. O exame oftalmológico completo mostrou estrias angióides bilaterais, drusas em ambas as áreas dos discos ópticos e membrana neovascular sub-retiniana na mácula esquerda. A análise genética revelou mutação no gene SH3BP2 compatível com o diagnóstico de Querubismo. A avaliação clínica e laboratorial descartou outros distúrbios sistêmicos. O Querubismo é uma doença óssea rara caracterizada pelo desenvolvimento de lesões fibro-ósseas indolores na mandíbula e maxila durante a primeira infância. Os achados oftalmológicos nesta doença estão principalmente relacionados ao envolvimento ósseo orbitário. Este artigo descreve pela primeira vez a ocorrência de estrias angióides e drusas de disco óptico no Querubismo. Enfatizamos que essa condição deve ser incluída no diferencial de pacientes com tais achados, principalmente quando ambos existirem em associação.

ABSTRACT A 65-year-old female patient was referred to our hospital for evaluation for cataract surgery. Her past medical history included corrective jaw surgeries for facial deformities that developed during infancy and persisted through early adulthood. A complete ophthalmological examination revealed bilateral angioid streaks, drusen in both optic disc areas, and a subretinal neovascular membrane in the left macula. Genetic analysis revealed a mutation in the SH3BP2 gene compatible with the diagnosis of cherubism. Clinical and laboratory evaluation revealed no additional systemic disorders. Cherubism is a rare disease characterized by the development of painless fibro-osseous lesions in the jaws and the maxilla in early childhood. Ophthalmologic findings in this disease are primarily related to orbital bone involvement. This is the first report of AS and optic disc drusen in a patient diagnosed with cherubism. Our findings suggest that angioid streaks and optic disk drusen should be included in the differential diagnosis of ophthalmic disorders identified in patients with this genetic abnormality.

Resumo Analisamos, por metodologia qualiquantitativa, a implementação da Lei n. 12.990/2014, que reserva 20% das vagas de concursos públicos federais para candidatos negros e negras, no âmbito das carreiras docentes de 63 universidades federais e de 38 institutos federais, no período 2014 a 2018. Constatamos que o percentual legalmente previsto está longe do praticado nas universidades federais e institutos federais. Passados mais de cinco anos desde a aprovação da lei, parece que o objetivo de ampliar a diversidade de raça/cor no serviço público federal não será alcançado por concursos para as carreiras docentes, em um cenário de recrudescimento de discursos meritocráticos que colocam em xeque a legitimidade de ações afirmativas para pessoas negras.

Abstract In this study, quali-quanti methodology was applied to analyze the implementation of Law no. 12,990/2014 on quotas for Black candidates at 63 federal universities and 38 federal ‘institutes’ (secondary and vocational training), during the period that spanned 2014 to 2018. The law reserves 20% of teaching vacancies filled through federal civil servant examinations for Black people. We observe the distance that separates the legally-stipulated conditions and actual practice in these institutions. As five years have now gone by since the passage of this legislation, it seems safe to say that the goal of expanding racial/color diversity in federal civil service will not be achieved through public examinations for teaching careers. Moreover, meeting this goal becomes progressively harder, given the present scenario of resurgence of meritocratic discourses that question the legitimacy of affirmative actions for Afro-Brazilians.

Resumen Analizamos, por metodología cuali-cuantitativa, la implementación de la Ley no. 12.990/2014, que reserva el 20% de las vacantes de concursos públicos federales para docencia en 63 universidades federales y 38 institutos federales a candidatos negros, en el periodo de 2014 a 2018. Constatamos que el porcentaje legalmente previsto está muy lejos del practicado en universidades federales e institutos federales. Transcurridos más de cinco años después de la aprobación de la ley, parece que el objetivo de ampliar la diversidad de raza/color en el servicio público federal no será alcanzado mediante concursos para carreras docentes, en un escenario de resurgimiento de discursos meritocráticos que amenazan la legitimidad de acciones afirmativas para personas negras.

Résumé Ce travail utilise une méthodologie quali-quantitative pour analyser l’application de la loi no 12 990/2014, réservant 20% des postes à des candidats noirs dans les concours de recrutement d’enseignants dans 63 universités féderales et 38 instituts superieurs d´éducation dans la période 2014-2018. Il a été constaté que le pourcentage prévu par la loi est loin de celui pratiqué par les universités fédérales et les instituts fédéraux. Passés cinq ans de l’adoption de la loi, il semble que l’objectif d’élargir la diversité concernant la race et la couleur de la peau dans la fonction publique ne sera pas atteint par le biais de concours de recrutement, dans un contexte de recrudescence des discours méritocratiques remettant en question la légitimité de la discrimination positive envers les noirs.