ABSTRACT BACKGROUND: Genitourinary health significantly affects the quality of life of men, particularly those in middle age. Recent studies have shown that more than half of the men aged over 40 years experience some degree of low urinary tract symptoms (LUTS) or erectile dysfunction (ED). OBJECTIVE: To assess the prevalence of ED and LUTS in middle-aged men and correlate this with quality of life data. DESIGN AND SETTING: A cross-sectional study was conducted in a municipality in the countryside of São Paulo. METHODS: A trained team collected data between July 2021 and August 2022 through face-to-face interviews using a characterization instrument, International Prostate Symptom Score (IPSS), International Index of Erectile Function-6 (IIEF-6), and World Health Organization Quality-of-Life Scale. RESULTS: The study included 375 male participants with a median age of 53 years (interquartile range [IQR] 38.5-66). The IIEF-6 showed the presence of some degree of ED in 51.1% (n = 188) of patients, with a median score of 25 (IQR 21-29). The IPSS revealed that 35.2% (n = 132) of the patients had some degree of LUTS, with a median score of 5 (IQR 2-11). The urological questionnaires had a direct proportional correlation with age (P < 0.001) and significant differences between the medians of different marital statuses (P < 0.001). The presence or severity of these disorders was inversely correlated with the individuals’ quality of life (P < 0.001). CONCLUSIONS: ED and LUTS significantly correlated with the quality of life, marital status, and age in men. BACKGROUND 4 (LUTS ED. . (ED) OBJECTIVE middleaged SETTING crosssectional cross sectional Paulo METHODS 202 facetoface face to instrument IPSS, , (IPSS) Function6 Function 6 Function- IIEF6, IIEF6 IIEF (IIEF-6) QualityofLife Quality Life Scale RESULTS 37 interquartile IQR [IQR 38.566. 38566 38.5 66 38 38.5-66) IIEF- 511 51 1 51.1 n 188 2 2129. 2129 21 29 21-29) 352 35 35.2 132 211. 211 11 2-11) P 0.001 0001 0 001 0.001. individuals CONCLUSIONS status (ED 20 (IPSS (IIEF-6 3 566 38.566 3856 385 38. 38.5-66 51. 18 212 21-29 35. 13 2-11 0.00 000 00 (IIEF- 56 38.56 38.5-6 21-2 2-1 0.0 (IIEF 38.5- 21- 2- 0.

Abstract Objective To determine the relationship between early age at menarche, late age at menopause with specific subtypes of breast cancer (BC). Methods A literature search was conducted in Embase, Lilacs, PubMed, Scopus, and Scielo databases, following the Joanna Briggs Institute scoping review protocol and answering the question “How early age at menarche or late age at menopause are related to different breast cancer subtypes?”. Results A number of 4,003 studies were identified, of which 17 were selected. Most of the included articles found a clear relationship between early menarche, late menopause and some subtypes of BC, mainly, PR+, ER+, luminal, and HER-2 tumors. However, some studies have found a contradictory relationship and one study didn’t find any relationship between them. Conclusion A relationship between early age at menarche and advanced age at menopause was observed with some subtypes of breast cancer, since other factors must be considered in its understanding. BC. BC . (BC) Embase Lilacs PubMed Scopus databases How subtypes. subtypes?” 4003 4 003 4,00 identified 1 selected mainly PR PR+ ER ER+ luminal HER2 HER 2 HER- tumors However didnt didn t them understanding (BC subtypes? 400 00 4,0 40 0 4,

ABSTRACT Objective To evaluate, characterize and search for trends in the underreporting of diabetes mellitus (DM) as the cause of death in Bauru, São Paulo, Brazil, over 40 years. Subjects and methods This was a documental study. Clinical and mortality data were collected from individuals known to have type 1 (DM1) and type 2 diabetes mellitus (DM2), residing in Bauru, State of São Paulo, followed at a local endocrinology clinic from 1982 to 2021, who deceased during this period. Results A significant underreporting of DM as the cause of death (64.41%) was found, mostly associated with male gender (OR = 1.59 [95% CI: 1.18; 2.15]; p < 0.01), DM2 (OR = 2.64 [95% CI: 1.32; 5.26]; p < 0.01), dying in the first decade of the study (OR = 4.07 [95% CI: 1.54; 10.71]; p < 0.001) and shorter DM duration (OR = 1.02 [95% CI: 1.01; 1.04]; p < 0.01). Age, type of treatment, body mass index, marital status and ethnicity, did not show a significant association with DM underreporting. There was a decreasing trend in DM1 underreporting (Decade Percentual Change = -7.10 [95% CI: -11.35; -3.40]), but a stationary trend for DM and DM2. The main primary cause of death was cardiovascular-related complications. Conclusion The underreporting of DM as the cause of death was very frequently found, and was associated with male gender, decade of death, shorter DM duration and DM2. If our data could be applied to the whole country, DM would possibly emerge as a more prominent cause of death in Brazil. Future studies in other cities and geographic regions are warranted to confirm our findings. evaluate (DM Bauru Paulo Brazil 4 years (DM1 DM2, , (DM2) 198 2021 period 64.41% 6441 64 41 (64.41% found OR 159 59 1.5 95% 95 [95 CI 1.18 118 18 2.15 215 15 2.15] 0.01, 001 0.01 0 01 0.01) 264 2.6 1.32 132 32 5.26 526 5 26 5.26] 407 07 4.0 1.54 154 54 10.71 1071 10 71 10.71] 0.001 0001 102 02 1.0 1.01 101 1.04 104 04 1.04] 0.01. . Age treatment index ethnicity Decade 7.10 710 7 -7.1 11.35 1135 11 35 -11.35 3.40, 340 3.40 3 -3.40]) cardiovascularrelated cardiovascular related complications country findings (DM2 19 202 64.41 644 6 (64.41 1. 9 [9 1.1 2.1 21 00 0.0 2. 1.3 13 5.2 52 4. 10.7 107 0.00 000 7.1 -7. 11.3 113 -11.3 34 3.4 -3.40] 20 64.4 (64.4 [ 0. 5. 10. 7. -7 11. -11. 3. -3.40 64. (64. - -11 -3.4 (64 -1 -3. (6 -3 (